ライフサイエンスコーパス: meibomian

1 in conjunctiva of the eyelid and in cells of Meibomian and preputial (sebaceous) glands.

2 lts correlated with the number of obstructed meibomian ducts (P = 0.005) and a pathologic meibomian g

3 scosity of meibum led to the dilation of the meibomian ducts, and the progressive degeneration of the

4 film breakup time (TBUT), corneal staining, meibomian dysfunction assessment, and conjunctival stain

5 the Oxford and van Bijsterveld indexes, and Meibomian dysfunction grading.

6 mark stem cells that play a critical role in Meibomian gland (MG) development and homeostasis, howeve

7 rneal epithelial disruption and lower eyelid meibomian gland (MG) dropout, adjusted for age and sex (

8 elial sodium channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction.

9 Meibomian gland (MG) formation is employed as a model wh

10 staining score (according to Oxford scale), meibomian gland (MG) loss rates of lower and upper eyeli

11 ation of dyslipidemia and its treatment with meibomian gland (MG) morphologic changes by standardized

12 o conclusive information about the impact of meibomian gland (MG) morphology in tear film physiology

13 esence of corneal subepithelial fibrosis and meibomian gland (MG) orifice metaplasia were recorded.

14 Age, gender, Schirmer's test, meibomian gland (MG) related parameters, lipid layer thi

15 evelopment, homeostasis and pathology of the Meibomian gland (MG).

16 Numerous nerve fibers near the meibomian gland acini were immunoreactive for NPY and VI

17 Immortalized human meibomian gland and conjunctival epithelial cells were c

18 ting stress showed hyperproliferation of the meibomian gland and ductal dilation suggesting a marked

19 he expression of numerous genes in the mouse meibomian gland and that many of these genes are involve

20 in anatomical and functional aspects of the meibomian gland are seen in SJS.

21 B presenting over seventeen months including meibomian gland assessment using a recognized classifica

22 Meibography imaging assessed for severe meibomian gland atrophy ( grade 2 atrophy; 1 eyelid on v

23 Meibography grading of meibomian gland atrophy and acini appearance, and slit-l

24 Meibomian gland atrophy and deterioration of meibum qual

25 omarker positivity was assessed in 16 severe meibomian gland atrophy cases after being found relevant

26 All severe meibomian gland atrophy cases had ocular symptoms/signs

27 In 16 severe meibomian gland atrophy cases, 62.5% tested positive for

28 In severe meibomian gland atrophy cases, 86% reported 4 hours of d

29 Patients with known meibomian gland atrophy causes or poor-quality meibograp

30 was not significantly associated with severe meibomian gland atrophy vs controls (P = .34, right-eye;

31 Aged heterozygotes also showed meibomian gland atrophy.

32 ctronic screen use is associated with severe meibomian gland atrophy.

33 , 11 years; 49% female): 17 cases had severe meibomian gland atrophy; 24 controls had insignificant g

34 redness, tear volume, anterior blepharitis, meibomian gland capping) and tear inflammatory cytokine

35 Consistent with this, we show that human Meibomian gland carcinoma exhibits increased Hh signalin

36 t cell cohesion is maintained differently in meibomian gland cells and indicate that Ecad is importan

37 The findings also show that the human meibomian gland contains several highly expressed genes

38 stemic, T-cell-dependent process that causes meibomian gland damage and induces a robust form of ocul

39 rmore, corneal stroma neovascularization and meibomian gland degeneration were examined by immunohist

40 subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), an

41 ents with dry eye who had rosacea-associated meibomian gland disease (MGD) or Sjogren's syndrome (SS)

42 Study groups included meibomian gland disease (MGD), aqueous tear deficiency (

43 hology, causes, and ocular surface impact of meibomian gland disease (MGD), as well as its relationsh

44 5 patients with DE, including subgroups with meibomian gland disease (MGD), Sjogren's syndrome (SS) a

45 ological changes are one of the key signs of meibomian gland disease (MGD).

46 ormal and 33 subjects with tear dysfunction (meibomian gland disease [n = 11], aqueous tear deficienc

47 ffective treatment for OSD that results from meibomian gland disease.

48 The meibomian gland dropout area (meiboscore) was calculated

49 Ocular rosacea is associated with marked meibomian gland dropout in both eyelids, with the lower

50 mmatory mediators (HIF-1alpha and MMP-2) and meibomian gland dropout in OSAS.

51 positively correlated with the total eyelid meibomian gland dropout values (r = 0,208, p < 0,05 and

52 Lower and total eyelid meibomian gland dropout values of the participants in th

53 The upper eyelid meibomian gland dropout values were higher in the severe

54 Meibomian gland dropout was evaluated with a tomograph a

55 ibum from normal donors (Mn) and donors with meibomian gland dysfunction (Md) by (1)H-NMR spectroscop

56 )H-NMR spectra of meibum from 39 donors with meibomian gland dysfunction (Md) were compared to meibum

57 is less ordered than meibum from donors with meibomian gland dysfunction (Md).

58 rading of clinical variables associated with meibomian gland dysfunction (MGD) in real-time examinati

59 It has been generally accepted that meibomian gland dysfunction (MGD) is a leading cause of

60 Meibomian gland dysfunction (MGD) is a major cause of ev

61 Meibomian gland dysfunction (MGD) is a primary cause of

62 Meibomian gland dysfunction (MGD) is the leading cause o

63 Meibomian gland dysfunction (MGD) is the leading cause o

64 Meibomian gland dysfunction (MGD) is the major cause of

65 Meibomian gland dysfunction (MGD) is the most common cau

66 Meibomian gland dysfunction (MGD) may be the leading cau

67 h regular eyelid shampoo on the treatment of meibomian gland dysfunction (MGD) signs and symptoms.

68 and the abnormalities of these glands cause Meibomian gland dysfunction (MGD) which is responsible f

69 The treatment of moderate to severe meibomian gland dysfunction (MGD) with oral doxycycline

70 lated to be necessary for the development of meibomian gland dysfunction (MGD), a common form of chro

71 ure changes in human meibum composition with meibomian gland dysfunction (MGD).

72 ned from 41 normal donors and 51 donors with meibomian gland dysfunction (MGD).

73 Twelve patients also had noninflamed meibomian gland dysfunction (MGD).

74 (TBUT), Schirmer's test, tear osmolarity and meibomian gland dysfunction (MGD).

75 of all DED cases are caused by some form of Meibomian gland dysfunction (MGD).

76 or the treatment of dry eye disease owing to meibomian gland dysfunction (MGD).

77 sted an association between dyslipidemia and meibomian gland dysfunction (MGD).

78 f depression has been found in patients with meibomian gland dysfunction (MGD); however, specific con

79 njunctivitis (OR: 3.76, 95% CI: 1.33-10.63), meibomian gland dysfunction (OR: 4.45, 95% CI: 1.9-10.40

80 oma, retinal vein occlusion, conjunctivitis, meibomian gland dysfunction and blepharitis, between pat

81 oma, retinal vein occlusion, conjunctivitis, meibomian gland dysfunction and blepharitis.

82 conjunctival staining, tear osmolarity, and meibomian gland dysfunction at baseline, 6 months, and 1

83 Their pathogenic potential in meibomian gland dysfunction is discussed herein.

84 Meibomian gland dysfunction is the most common etiology

85 investigating the linkage of lid changes and meibomian gland dysfunction may shed new lights on the p

86 Meibum lipid compositional changes with meibomian gland dysfunction reflect changes in hydrocarb

87 time, Oxford Schema, Schirmer's test I, and meibomian gland dysfunction testing.

88 time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a com

89 its associated lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye.

90 igating ocular surface pathologies involving meibomian gland dysfunction, blepharitis, corneal or con

91 s, accompanied by tear hyperosmolarity, mild meibomian gland dysfunction, reduced BUT, mucus filament

92 Restasis) may also have a positive effect on meibomian gland dysfunction, the other main form of dry

93 gesting a pathogenic role in blepharitis and meibomian gland dysfunction.

94 e pathology of the ocular surface resembling Meibomian gland dysfunction.

95 Immortalized human meibomian gland epithelial (SLHMG) cells were examined f

96 g), and promoted lipid accumulation in human meibomian gland epithelial cells (about 2-fold increase

97 ied the regulation of cell cohesion in human meibomian gland epithelial cells (HMGECs).

98 the lipogenesis and differentiation of human meibomian gland epithelial cells (HMGECs).

99 port the hypothesis that IGF-1 acts on human meibomian gland epithelial cells and may explain why tre

100 It was possible to isolate viable human meibomian gland epithelial cells and to culture them in

101 Meibomian gland epithelial cells are essential in mainta

102 The results show that human meibomian gland epithelial cells may be isolated, cultur

103 demonstrate that EGF and BPE stimulate human meibomian gland epithelial cells to proliferate.

104 N, SETTING, AND MATERIAL: Immortalized human meibomian gland epithelial cells were cultured in the pr

105 To test our hypotheses, immortalized human meibomian gland epithelial cells were cultured with or w

106 shes the differentiation and adipogenesis of meibomian gland epithelial cells, and both mTOR complexe

107 eir agonists influence the function of human meibomian gland epithelial cells.

108 ication of IGF-1 and growth hormone to human meibomian gland epithelial cells.

109 tiation (e.g., lipid accumulation), of human meibomian gland epithelial cells.

110 its a pronounced lipid accumulation in human meibomian gland epithelial cells.

111 ammatory mediator and protease expression in meibomian gland epithelial cells.

112 , keratinization, and inflammation, in human meibomian gland epithelial cells.

113 icant, time-dependent proliferation of human meibomian gland epithelial cells.

114 d attenuates cell survival pathways in human meibomian gland epithelial cells.

115 chirmer test results without anesthesia, and meibomian gland examination.

116 eyelid margin measurements, meibum quality, meibomian gland expressability, ocular surface disease i

117 esis in the study was that androgens control meibomian gland function, regulate the quality and/or qu

118 ells and indicate that Ecad is important for meibomian gland function.

119 x, Ocular Surface Staining, Schirmer I test, Meibomian gland functionality in 757 patients (1514 eyes

120 This study was conducted to identify meibomian gland genes that may promote the development a

121 Therapeutically, anti-inflammatory therapy, meibomian gland heating and expression, and scleral cont

122 ilm osmolarity, inflammatory biomarkers, and meibomian gland imaging.

123 n, platinum segment insertion, correction of meibomian gland inversion (MGI), full-thickness skin gra

124 hypothesis that the androgen control of the meibomian gland involves the regulation of gene expressi

125 The findings show that the meibomian gland is an androgen target organ and that and

126 In prior work, it has been found that the meibomian gland is an androgen target organ, that androg

127 A striking characteristic of the human meibomian gland is its rich sensory, sympathetic, and pa

128 al abnormalities are not solely dependent on meibomian gland lipid secretion.

129 thickness (LLT); tear meniscus height (TMH); meibomian gland loss (MGL); tear osmolarity.

130 In conclusion, evaluation of meibomian gland loss and distortion are valuable complem

131 Meibomian gland loss was significantly higher in both up

132 nd lower), 160 (65%) eyelids revealed severe meibomian gland loss.

133 est new approaches to treat aging-associated Meibomian gland loss.

134 Neither specific aqueous nor meibomian gland measurements were significantly correlat

135 e modeling to identify relationships between Meibomian gland morphological features and subject demog

136 77%, 76%, and 86% accuracies for predicting Meibomian gland morphological features, subject age, and

137 Meibomian gland obstruction and meibocyte depletion are

138 The paper studied the meibomian gland of 30 RA cases referred by the Rheumatol

139 Plugging and capping of meibomian gland orifices, foamy tear, glands expressibil

140 on between symptoms and global, aqueous, and meibomian gland parameters.

141 eal staining, tear breakup time, Schirmer's, meibomian gland quality, orifice plugging, lid vasculari

142 meibomian ducts (P = 0.005) and a pathologic meibomian gland secretion (P = 0.001).

143 These findings also suggest that meibomian gland secretion is under the control of divers

144 e Disease Index, tear film breakup time, and meibomian gland secretion quality.

145 Human meibomian gland secretions (meibum) were analyzed by ele

146 lar components of the lipids in normal human meibomian gland secretions (meibum).

147 tty acids and the fatty acid amides in human meibomian gland secretions by using electrospray mass sp

148 he production, secretion, and/or delivery of meibomian gland secretions to the ocular surface, the go

149 Aging-related Meibomian gland shrinkage may result in part from stem c

150 The identities and niche of Meibomian gland stem cells and the signals controlling t

151 This study highlights the need to evaluate meibomian gland structure and function in patients with

152 The response of the meibomian gland to desiccating stress also suggest that

153 In this study, only the meibomian gland was affected among the anterior segment

154 ontent, and fatty acid profile of the rabbit meibomian gland, as well as the appearance of the tear f

155 However, its specific role in the Meibomian gland, where lipid metabolism is significant,

156 biomarker positivity in children with severe meibomian gland-atrophy.

157 thetic preganglionic neurons that project to meibomian gland-innervating ganglion cells are located i

158 d in the search documented an improvement in meibomian gland-related OSD after treatment with these a

159 r role in the sex-related differences of the meibomian gland.

160 significant impact on gene expression in the meibomian gland.

161 ression of more than a thousand genes in the meibomian gland.

162 mine whether neurotransmitters influence the meibomian gland.

163 expression of almost 400 genes in the human meibomian gland.

164 y multiple changes in gene expression in the meibomian gland.

165 progesterone modulate gene expression in the meibomian gland.

166 progesterone regulate gene expression in the meibomian gland.

167 he expression of numerous genes in the mouse meibomian gland.

168 ression of more than 1590 genes in the mouse meibomian gland.

169 n of IGF-1 action in epithelial cells of the meibomian gland.

170 in the sex-related differences of the mouse meibomian gland.

171 terations in the lipid content of the rabbit meibomian gland; 19-nortestosterone treatment modulated

172 al and neutral lipid fractions of the rabbit meibomian gland; and androgens did not appear to influen

173 In aqueous-deficient dry eye (ADDE) and Meibomian-gland dysfunction (MGD), compositional changes

174 Secretions that are produced by meibomian glands (also known as meibum) are a major sour

175 mpact of Elovl3 inactivating mutation on the Meibomian glands (MG) and conjunctiva of mice.

176 Meibomian glands (MG) are large sebaceous glands located

177 Meibum-a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis-p

178 osynthesis of FAlc and FAld in mammals using Meibomian glands (MG) of wild-type (WT) and Sdr16c5/Sdr1

179 ime (TBUT), Tear Film Meniscus Height (TMH), Meibomian glands (MG), and Lipid Layer Thickness (LLT) w

180 result in a marked enlargement of the mouse Meibomian glands (MGs) and sebaceous glands, respectivel

181 Lipids secreted by the meibomian glands (MGs) of the eyelids are essential to t

182 Exocrine meibomian glands (MGs) play a central role in the ocular

183 e physiology of the mouse ocular surface and Meibomian glands (MGs).

184 ment and the commonest was an anomaly of the meibomian glands and lacrimal drainage system defects.

185 in staining, TBUT, osmolarity, and secreting meibomian glands and meibum quality were also seen.

186 The meibomian glands and other structures within the lid mar

187 o impaired vitamin A metabolism, loss of the meibomian glands and recurrent eyelid trauma.

188 nic eyelid closure as well in development of meibomian glands and the anterior segment of the eye.

189 The meibomian glands and the lipid layer thickness had the s

190 exists in the epithelial cell nuclei of rat meibomian glands and, in addition, whether androgen defi

191 nance of primary epithelial cells from human meibomian glands and, second, to immortalize these cells

192 Both the lipid layer and meibomian glands are not affected.

193 Murine lacrimal, harderian and meibomian glands develop from the prospective conjunctiv

194 luorescein corneal stain, and assessment for meibomian glands dysfunction (MGD) were carried out.

195 tablish reliable morphologic measurements of meibomian glands for evaluating MGD severity.

196 Because lipid production was unaltered in meibomian glands from Dsg3-deficient mice, we establishe

197 Meibomian glands from intact, androgen- and/or placebo-t

198 ty has no obvious effect on the histology of meibomian glands in male or female mice.

199 l injections (IVI) on the ocular surface and meibomian glands in patients with neovascular age-relate

200 eous glands (SGs) or in free SGs such as the Meibomian glands in the eyelids.

201 upper lids, total mebioscore, percentage of meibomian glands in upper and lower lids, first non-inva

202 upper lids, total meiboscore, percentage of meibomian glands in upper and lower lids, NIV-BUT of the

203 glands were significantly enlarged, and the meibomian glands malformed.

204 The meibomian glands of rhesus and cynomolgous monkeys are r

205 lities in the fur texture and the absence of meibomian glands prompted us to evaluate other epidermal

206 expression in cutaneous sebaceous vs eyelid Meibomian glands remain to be established.

207 Meibomian glands secrete lipid-rich meibum, which preven

208 ith mechanical expression of lipids from the meibomian glands successfully treats dry eye symptoms an

209 sebaceous carcinomas apparently derived from Meibomian glands were also negative (n = 12).

210 Meibomian glands were isolated and processed for RNA ext

211 Meibomian glands were obtained from adult, age-matched w

212 Meibomian glands were obtained from orchiectomized mice

213 Meibomian glands were obtained from young adult, ovariec

214 Human meibomian glands were removed from lid segments after su

215 ring a transgene for the Eda-A1 isoform, but meibomian glands were restored little if at all.

216 In the eyelid, Meibomian glands were uniformly negative for 15-lipoxyge

217 lts indicate that aging mice show dropout of meibomian glands with loss of gland volume and a forward

218 Meibomian glands within the eyelid are important for the

219 anterior eye segment defects, absence of the meibomian glands, and defects in the semilunar cardiac v

220 luding hypertrophic salivary, sebaceous, and meibomian glands, as well as enhanced squamous tumorigen

221 essenger RNA is also present in lacrimal and meibomian glands, as well as in a number of other tissue

222 lopment and maturation of both sebaceous and meibomian glands, as well as in the formation and compos

223 hair growth after shaving and also enlarged meibomian glands, consistent with a nearly 80% reduction

224 plications, including the destruction of the meibomian glands, irregularity of the eyelid margin, and

225 in sebocytes, and attenuates SGs and eyelid meibomian glands, leading to corneal ulceration.

226 scosity could alter secretion of lipids from meibomian glands, or tear-film stabilization properties

227 Many pathologies can disrupt function of meibomian glands, ranging from congenital to acquired ca

228 mal development of both sebaceous glands and meibomian glands, specialized sebaceous glands of the ey

229 airs arising inappropriately from the eyelid meibomian glands-which is evident from birth.

230 erior segment of the eye, and the absence of meibomian glands.

231 anterior segment defects and the absence of meibomian glands.

232 d bulbar conjunctiva, corneal epithelium and meibomian glands.

233 ility and quality of meibum, and drop-out of meibomian glands.

234 ctopic row of hair follicles in place of the Meibomian glands.

235 r and ectopic cilia formed at the expense of Meibomian glands.

236 dant in the eyelid, which contains wax-laden meibomian glands.

237 ant second row of eyelashes arising from the meibomian glands.

238 me; and (2) trophic effects on sebaceous and Meibomian glands.

239 ed for the maintenance of both sebaceous and meibomian glands.

240 ed to the basement membranes of acini of the meibomian glands.

241 ing TH, CGRP, and SP were more sparse in the meibomian glands.

242 te associated changes of the lid margins and meibomian glands.

243 with the expressibility and the drop-out of meibomian glands.

244 automated lipid expression (Lipiflow) of the Meibomian glands.

245 n managing OSD arising from disorders of the meibomian glands.

246 ent of OSD that arises from disorders of the meibomian glands.

247 ands and contributes to the formation of the meibomian glands.

248 that 1) as previously reported, mice lacked meibomian glands; 2) >80% developed corneal lesions such

249 within acinar epithelial cell nuclei of rat meibomian glands; androgen deficiency was associated wit

250 eral corneal, or bulbar conjunctival stroma; meibomian glands; skin; retina-choroid; or episcleral re

251 e (TBUT), corneal and conjunctival staining, meibomian grading, and Ocular Surface Disease Index and

252 While mucosal and meibomian layers have been extensively studied, the role

253 imals, canines, mice, and rabbits, for their meibomian lipid composition in order to determine which

254 determine the biophysical parameters of thin meibomian lipid film (MLF): the lift-off area, collapse

255 ceramide (Cer) and free cholesterol (FC) on meibomian lipid films (MLF) using a Langmuir trough (LT)

256 The rabbit meibomian lipidome, on the other hand, was vastly differ

257 he closest match to humans in terms of their meibomian lipidomes, while canines were the second close

258 animal species have been evaluated for their meibomian lipidomes.

259 ering the natural variability range for most meibomian lipids (app. +/- 15% of the Mean), these diffe

260 The mutation affected major classes of meibomian lipids - cholesteryl esters, wax esters, and c

261 Meibomian lipids are the primary component of the lipid

262 Bovine and human meibomian lipids exhibit similar physical properties.

263 barrier is disrupted, creating potential for meibomian lipids to adhere more strongly.

264 nd structural properties of human and bovine meibomian lipids to provide insight into the physical be

265 Bulk rheological properties of pooled meibomian lipids were measured by a commercial stress-co

266 one, which was tied to differences in their meibomian lipids.

267 erfacial viscoelasticity of spread layers of meibomian lipids.

268 human meibum are one of the largest group of meibomian lipids.

269 ds and ocular [lacrimal, harderian (HG), and meibomian (MG)] glands and is necessary for normal ocula

270 surface staining (OSS), Schirmer's test, and meibomian quality and expressibility.

271 sing Schirmer information, lid plugging, and meibomian quality to define objective DES, 176 patients

272 staining (r(2) = 0.43), OSDI (r(2) = 0.41), meibomian score (r(2) = 0.37), TBUT (r(2) = 0.30), and S

273 Meibomian structural alterations in children can be seve

274 appear to influence the gross morphology of meibomian tissue or to exert a demonstrable effect on th

275 ation patterns of their extremely long chain Meibomian-type counterparts.

276 r abnormal sebaceous-type lipidome or normal Meibomian-type lipidome in WT mice.

277 lity to produce typical extremely long chain Meibomian-type lipids at seemingly normal levels.

278 nthesis of monounsaturated and diunsaturated Meibomian-type WEs.

279 analyze more than 100 individual species of meibomian WE, which were shown to comprise 41 +/- 8% (wt

280 al information on previously uncharacterized meibomian WE.