ライフサイエンスコーパス: meiotic recombination

1 nd annealing, break-induced replication, and meiotic recombination.

2 cific ssDNA-binding protein, regulates early meiotic recombination.

3 velope, facilitating chromosomal pairing and meiotic recombination.

4 have important implications in understanding meiotic recombination.

5 insight into kinetochore-derived control of meiotic recombination.

6 equires crossover-fated events formed during meiotic recombination.

7 vel role for UNC-84 in DNA damage repair and meiotic recombination.

8 y and establish a role for the centrosome in meiotic recombination.

9 xt of the Sgs1-Top3-Rmi1 complex to regulate meiotic recombination.

10 in the regulation of gene transcription and meiotic recombination.

11 ole for MEIOB in crossover formation in late meiotic recombination.

12 ying homolog polymorphism patterns can shape meiotic recombination.

13 provide new information on the mechanism of meiotic recombination.

14 mplex functions with the DMC1 recombinase in meiotic recombination.

15 mosome revealed partitioning correlated with meiotic recombination.

16 licated in double strand break repair during meiotic recombination.

17 rDNA) array, however, undergoes little or no meiotic recombination.

18 in how it mediates homologous DNA pairing in meiotic recombination.

19 hat creates double-strand breaks to initiate meiotic recombination.

20 urgidum ssp. durum) utilizes two pathways of meiotic recombination.

21 e sibling diversity approaching that seen in meiotic recombination.

22 ch undergoes copy-number changes mediated by meiotic recombination.

23 significance of a "pioneer complex" in mouse meiotic recombination.

24 M activity of Rad51 is fully dispensable for meiotic recombination.

25 tion of plant genomes through the control of meiotic recombination.

26 t this interplay may be a general feature of meiotic recombination.

27 ious alleles or stack beneficial alleles via meiotic recombination.

28 the pairing of homologous chromosomes during meiotic recombination.

29 Dmc1's JM activity alone is responsible for meiotic recombination.

30 explain other, seemingly complex features of meiotic recombination.

31 ired telomeric repeats and were dependent on meiotic recombination.

32 enetic dissection of mechanisms that control meiotic recombination.

33 e segregation, and repression of pericentric meiotic recombination.

34 s are introduced into the genome to initiate meiotic recombination.

35 functional and genomic features analysis of meiotic recombination.

36 e opposing arm's centromere during zebrafish meiotic recombination.

37 endogenous DNA damage, and also occur during meiotic recombination.

38 an 25 years, has only been identified during meiotic recombination.

39 t tenfold lower levels (per DSB) than during meiotic recombination.

40 isms for the regulation of transcription and meiotic recombination.

41 some arms, coincident with zones of elevated meiotic recombination.

42 rge regions of the genome with low levels of meiotic recombination.

43 replication forks, telomere dysfunction, and meiotic recombination.

44 d by Ctp1, which plays an additional role in meiotic recombination.

45 in many aspects of DNA metabolism including meiotic recombination.

46 wn for its role with Dmc1 recombinase during meiotic recombination.

47 es of DNA double-strand breaks that initiate meiotic recombination.

48 ods and understanding the molecular basis of meiotic recombination.

49 prophase I, consistent with MSH2 regulating meiotic recombination.

50 ols used by fruit fly geneticists to prevent meiotic recombination.

51 it meiotic HORMADs, the master regulators of meiotic recombination.

52 vealing a role for chromatin organization in meiotic recombination.

53 ining base triplets may contribute to normal meiotic recombination.

54 med DNA double-strand breaks (DSBs) initiate meiotic recombination.

55 other axis-associated protein with a role in meiotic recombination.

56 en found to link changes in SC dynamics with meiotic recombination.

57 romeric regions that are virtually devoid of meiotic recombination.

58 hromosomes in pachytene cells, which undergo meiotic recombination.

59 much progress has been made in understanding meiotic recombination.

60 subtelomeric regions, it locally influences meiotic recombination.

61 known homeostatic mechanisms that act during meiotic recombination.

62 ures governing successive steps in mammalian meiotic recombination.

63 instability is a failure to up-regulate the meiotic recombination 11 (Mre11) nuclease in S phase, wh

64 ed and recruited by the MRN protein complex [meiotic recombination 11 (Mre11)/DNA repair protein Rad5

65 Meiotic recombination 11 homolog (MRE11) is downregulate

66 h homologous recombination (HR) by requiring meiotic recombination 11 homolog A (Mre11) nuclease acti

67 During meiotic recombination, a subset of programmed DNA double

68 plays a key role in establishing domains of meiotic recombination along chromosomes.

69 man enhancer of invasion-10 (Hei10) mediates meiotic recombination and also plays roles in cell proli

70 r results suggest that MEIOB is required for meiotic recombination and chromosomal synapsis.

71 Meiotic recombination and chromosome assortment events d

72 Meiotic recombination and de novo mutation are the two m

73 ations identify a novel function of CUL4A in meiotic recombination and demonstrate an essential role

74 f FANCI and FANCD2 during mouse development, meiotic recombination and hematopoiesis.

75 direct evidence of how Rad51 is required for meiotic recombination and highlight a regulation strateg

76 that associate with female fertility, female meiotic recombination and neurological disease.

77 onary forces that can lead to a cessation of meiotic recombination and the accumulation of structural

78 erein it must possess the ability to undergo meiotic recombination and the capacity to differentiate

79 provide new insights into the regulation of meiotic recombination and the impact of meiotic recombin

80 e very useful insights into the mechanism of meiotic recombination and the process of genome evolutio

81 + family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoin

82 eview, we focus on advances in understanding meiotic recombination and then summarize the attempts to

83 omplex may allow the chromosomes to regulate meiotic recombination, and a stable complex may be requi

84 aintenance, cell cycle checkpoint signaling, meiotic recombination, and DNA double-stranded break (DS

85 rast, BRCA1 plays a relatively minor role in meiotic recombination, and female Brca1 mutants are fert

86 as a profound effect on the FOA dynamics and meiotic recombination, and it implicates an RT-dependent

87 play an important role in the progression of meiotic recombination, and maintain ribosomal DNA stabil

88 ted steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into

89 preprogrammed double-strand breaks initiate meiotic recombination, and the checkpoints that govern t

90 rring in the p53(-) germline were incited by meiotic recombination, and transcripts produced from the

91 his suggests individuals with lower rates of meiotic recombination are at an increased risk of produc

92 Gene conversions resulting from meiotic recombination are critical in shaping genome div

93 Two known types of meiotic recombination are crossovers and gene conversion

94 ed double-strand breaks (DSBs) that initiate meiotic recombination are dangerous lesions that can dis

95 NA double-strand breaks (DSBs) that initiate meiotic recombination are directed to a subset of genomi

96 DNA double-strand breaks that initiate meiotic recombination are exonucleolytically processed.

97 While mechanisms of DNA repair during meiotic recombination are well characterized, the same i

98 Rates of meiotic recombination are widely variable both within an

99 this end, we report the local stimulation of meiotic recombination at a number of chromosomal sites b

100 on the Spo11 (Rec12)-dependent initiation of meiotic recombination at hotspots?

101 rid to investigate genome-wide variation and meiotic recombination at nucleotide resolution.

102 omologues, as well as direct comparison with meiotic recombination at the same locus.

103 Meiotic recombination begins with the induction of progr

104 chromosome segregation and fertility require meiotic recombination between homologous chromosomes rat

105 The rate of meiotic recombination between markers located in euchrom

106 ly clustering deleted genomic segments using meiotic recombination between the bacterial genomes harb

107 olog, Sgs1, plays an integral role in normal meiotic recombination, beyond its documented activity li

108 Meiotic recombination breaks down linkage disequilibrium

109 ion and frequency of Spo11 (Rec12)-initiated meiotic recombination, but paradoxically they are suicid

110 Initiation of meiotic recombination by DNA double-strand break formati

111 ission yeast Rec12 (Spo11 homolog) initiates meiotic recombination by forming developmentally program

112 complexes together coordinate and facilitate meiotic recombination by recruiting key proteins for ini

113 ts demonstrate that the outcome of mammalian meiotic recombination can be biased, that this bias can

114 However, misplaced meiotic recombination can have catastrophic consequences

115 hat such rearrangement-mediated reduction of meiotic recombination can lead to genetically isolated h

116 Therefore, activation of the meiotic recombination checkpoint, which arrests meiotic

117 t is due to unrepaired breaks triggering the meiotic recombination checkpoint.

118 These results demonstrate how meiotic recombination combines with an ancient, preserve

119 SNP and indel markers to analyze patterns of meiotic recombination, confirming a high rate of crossov

120 About 40% of the hotspots for meiotic recombination contain the degenerate consensus s

121 This identifies a novel mode of meiotic recombination control via a general transcriptio

122 ethods will facilitate genetic dissection of meiotic recombination control.

123 light on the mechanism of action of Hed1 in meiotic recombination control.

124 Meiotic recombination creates genetic diversity and ensu

125 Meiotic recombination, crucial for proper chromosome seg

126 Using a meiotic recombination dataset, we show that ssG is more

127 allow us to accelerate crop breeding, where meiotic recombination distributions can be limiting.

128 During meiotic recombination, double-strand breaks (DSBs) are f

129 Meiotic recombination drives eukaryotic sexual reproduct

130 ed double-strand breaks (DSBs) that initiate meiotic recombination (e.g., hundreds per meiocyte in mi

131 Meiotic recombination enables reciprocal exchange of gen

132 Meiotic recombination enables the reciprocal exchange of

133 p53 and POLiota also act together to promote meiotic recombination enzyme 11 (MRE11)-dependent accumu

134 LSH may be essential to prevent deleterious meiotic recombination events at repetitive centromeric s

135 assessing effects of micronutrient status on meiotic recombination events in human sperm.

136 anisms implicates a role for BLM helicase in meiotic recombination events, prompting us to explore th

137 nt source of germline mutations, as sites of meiotic recombination experience recurrent double-strand

138 Meiotic recombination facilitates the transmission of ex

139 spermatogenesis with Prdm9, as an essential meiotic recombination factor required for efficient repa

140 Consistent with a role in meiotic recombination, FANCI interacted with RAD51 and s

141 Despite the universal importance of meiotic recombination for generating genetic diversity,

142 Meiotic recombination frequency varies at multiple scale

143 The Y chromosome, inherited without meiotic recombination from father to son, carries relati

144 that, to the contrary, Top3-Rmi1 acts in all meiotic recombination functions previously associated wi

145 oid meiosis can be enhanced by loss of a key meiotic recombination gene.

146 Meiotic recombination generates crossovers between homol

147 in determining sequence-specific hotspots of meiotic recombination genome wide.

148 he double-strand breaks (DSBs) that initiate meiotic recombination greatly outnumber eventual COs, th

149 Meiotic recombination has a profound effect on patterns

150 ven unfavorable chromosome interactions when meiotic recombination has to proceed in genotoxic enviro

151 During meiotic recombination, homologue-templated repair of pro

152 me-wide analyses have suggested thousands of meiotic recombination hot spots across mammalian genomes

153 9 (PRDM9) protein is a major determinant of meiotic recombination hot spots and acts through sequenc

154 en identified as a likely trans regulator of meiotic recombination hot spots in humans and mice.

155 observed in the locations and activities of meiotic recombination hot spots.

156 s for histone acetylation marks at mammalian meiotic recombination hot spots.

157 fic KRAB-ZFPs, including genomic imprinting, meiotic recombination hotspot choice, and placental grow

158 PRDM9 plays a key role in specifying meiotic recombination hotspot locations in humans and mi

159 histone H3 methyltransferase that specifies meiotic recombination hotspots during gametogenesis.

160 tein PRDM9 has a critical role in specifying meiotic recombination hotspots in mice and apes, but it

161 t mutations, copy number variations, and the meiotic recombination hotspots utilized by males and fem

162 PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of

163 ed complexity of the epigenetic landscape at meiotic recombination hotspots.

164 Our results demonstrate that MEIOB regulates meiotic recombination in a dosage-dependent manner.

165 s homology search and strand exchange during meiotic recombination in budding yeast and many other or

166 Meiotic recombination in budding yeast requires two RecA

167 of joint molecule intermediates (JMs) during meiotic recombination in budding yeast.

168 op2-Mnd1 specifically stimulates Dmc1 during meiotic recombination in budding yeast.

169 g data, suggest that DNA methylation affects meiotic recombination in cis.

170 covers the repressive role of methylation on meiotic recombination in euchromatic regions and suggest

171 of function may trigger changes that enhance meiotic recombination in euchromatin regions but are not

172 r regions, they are drastically depleted for meiotic recombination in heterozygotes.

173 e, we illuminate how strands exchange during meiotic recombination in male mice by analyzing patterns

174 he double-strand breaks (DSBs) that initiate meiotic recombination in mice and humans.

175 Meiotic recombination in most mammals requires recombina

176 tion of crossovers (COs) between homologs by meiotic recombination in most species.

177 Here, when analyzing meiotic recombination in mutant plants with hypomethylat

178 Last, we pay special attention to the meiotic recombination in polyploidy, which is a common g

179 5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.

180 s recombination, a process that differs from meiotic recombination in sexual organisms.

181 n pericentromeric regions-the cold spots for meiotic recombination in soybean-showed significantly lo

182 e genomic region, we found that interhomolog meiotic recombination in the array is reduced compared t

183 pe of chromosomal recombination, we analyzed meiotic recombination in the decreased DNA methylation 1

184 uminate broad similarities in the control of meiotic recombination in these diverse species but also

185 ombination events, which are consistent with meiotic recombination in this primarily haploid organism

186 d an orthologue of dmc1, a gene specific for meiotic recombination in yeast, in 3 species of Pneumocy

187 required for all known functions of Sgs1 in meiotic recombination, including channeling JMs into phy

188 Meiotic recombination, including crossovers (COs) and ge

189 The nonrandom distribution of meiotic recombination influences patterns of inheritance

190 ndings reveal that the process of initiating meiotic recombination inherently selects against nuclei

191 Meiotic recombination initiated by programmed double-str

192 Meiotic recombination initiates following the formation

193 budding yeast genome contains regions where meiotic recombination initiates more frequently than in

194 Meiotic recombination initiates via programmed double-st

195 Meiotic recombination initiates with formation of develo

196 Two high-resolution maps of meiotic recombination initiation sites across the genome

197 rosophila, we discovered that the process of meiotic recombination instigates programmed activation o

198 To analyze another product of meiotic recombination, interhomolog noncrossovers (NCOs)

199 ations to END-seq, we identify a SPO11-bound meiotic recombination intermediate (SPO11-RI) present at

200 ome stability complex, we observe persistent meiotic recombination intermediates (DNA joint molecules

201 Instead, it probably processes meiotic recombination intermediates by nicking double-st

202 been implicated in the biased processing of meiotic recombination intermediates into crossovers by a

203 ic distribution of MutSgamma and RFC-PCNA on meiotic recombination intermediates may drive biased DNA

204 ip4:Spo16 complex binds and stabilizes early meiotic recombination intermediates, then coordinates ad

205 ions in male germ cells to promote repair of meiotic recombination intermediates, thereby improving t

206 binds specific DNA structures found in early meiotic recombination intermediates.

207 A key step in meiotic recombination involves the nucleolytic resolutio

208 Meiotic recombination is a critical step in gametogenesi

209 Meiotic recombination is a fundamental cellular mechanis

210 Meiotic recombination is a major driver of genetic diver

211 Meiotic recombination is an essential feature of sexual

212 Since meiotic recombination is coupled with synaptonemal compl

213 pecies have revealed two mechanisms by which meiotic recombination is directed to the genome-through

214 f DNA double-strand breaks (DSBs) initiating meiotic recombination is elevated in Saccharomyces cerev

215 Meiotic recombination is essential for fertility in most

216 Meiotic recombination is essential for producing healthy

217 In Saccharomyces cerevisiae (budding yeast), meiotic recombination is increased in the absence of the

218 Meiotic recombination is initiated by programmed DNA dou

219 Meiotic recombination is initiated by programmed DNA dou

220 Meiotic recombination is initiated by programmed double

221 In fission yeast, meiotic recombination is initiated by Rec12 (Spo11 homol

222 Meiotic recombination is initiated by SPO11-induced doub

223 Meiotic recombination is initiated by the formation of D

224 Meiotic recombination is initiated by the programmed ind

225 many organisms, including yeasts and humans, meiotic recombination is initiated preferentially at a l

226 Crossover localization during meiotic recombination is mediated by the fast-evolving z

227 affect chromosome structure, their impact on meiotic recombination is not well understood.

228 Therefore, elucidating how meiotic recombination is positioned is of fundamental an

229 The basis by which centromeric meiotic recombination is repressed has been largely unkn

230 Meiotic recombination is required for correct segregatio

231 Meiotic recombination is required for the segregation of

232 Meiotic recombination is the foundation for genetic vari

233 Meiotic recombination is the fundamental process that pr

234 Meiotic recombination is tightly regulated by cis- and t

235 ecies such as barley (Hordeum vulgare) where meiotic recombination is very heavily skewed to the ends

236 They provide compelling evidence that most meiotic recombination is, like transcription, regulated

237 and repeat-associated DNA methylation on the meiotic recombination landscape of an Arabidopsis mappin

238 In addition, Cep63 loss severely impairs meiotic recombination, leading to profound male infertil

239 gh cohesin is required for the completion of meiotic recombination, little is known about how cohesin

240 males and fem-3 worms is a substrate for the meiotic recombination machinery and repair of the result

241 Fine scale meiotic recombination maps have uncovered a large amount

242 fied by successive megachunk integration and meiotic recombination-mediated assembly, producing a fun

243 Hop2-Mnd1 is a meiotic recombination mediator that stimulates DNA stran

244 NA breaks that are the initiating events for meiotic recombination, most organisms make very few cros

245 Female infertility caused by a meiotic recombination mutation or irradiation was revers

246 Extensive variation in the frequency of meiotic recombination occurs along chromosomes and is ty

247 In mammals, meiotic recombination occurs at 1- to 2-kb genomic regio

248 In many organisms, meiotic recombination occurs preferentially at a limited

249 n of meiotic recombination and the impact of meiotic recombination on genome function.

250 Meiotic recombination, one of the central biological pro

251 tions occur during normal processes, such as meiotic recombination or B cell development, and others

252 ructure, meiosis-specific telomere behavior, meiotic recombination, pairing, synapsis, and installati

253 o profile hotspots at different steps of the meiotic recombination pathway that have been used in dif

254 omes, that is, heterozygosity, can influence meiotic recombination pathways in cis and trans.

255 tent cells and their derivatives, as well as meiotic recombination patterns.

256 Meiotic recombination predominantly occurs at discrete g

257 matic cells, less is known about its role in meiotic recombination primarily because of the embryonic

258 Meiotic recombination proceeds via binding of RPA, RAD51

259 ak (DSB) formation is the initiating step of meiotic recombination, producing, among other outcomes,

260 Meiotic recombination promotes genetic diversification a

261 ataxia telangiectasia mutated gene 1 (ATM), meiotic recombination protein 11 (MRE-11), and others].

262 election is a key determinant for organizing meiotic recombination, providing evidence that genome-wi

263 hisms across homologs has a strong impact on meiotic recombination rate.

264 chromatin, increased gene density, elevated meiotic recombination rates and in the proximity of repe

265 dditionally, there was a correlation between meiotic recombination rates and targeting frequencies at

266 Meiotic recombination rates can vary widely across genom

267 ent to the existing procedures of estimating meiotic recombination rates from population genetic data

268 meiosis and various evolutionary processes, meiotic recombination rates sometimes vary within specie

269 Meiotic recombination rates vary considerably between sp

270 Meiotic recombination rates vary greatly along the chrom

271 e segregation and offspring diversification, meiotic recombination rates vary within and between spec

272 that for this region in the genome, enhanced meiotic recombination rates, as well as other as-of-yet

273 st syntenic blocks occur in regions with low meiotic recombination rates, no transposable elements, a

274 erest to understand and utilize variation in meiotic recombination rates.

275 ere generated and analyzed by sequencing for meiotic recombination, representing the first tetrad ana

276 f S. tuberosum as a model for autotetraploid meiotic recombination research and highlight constraints

277 Meiotic recombination results in the formation of cytolo

278 The nonrandom distribution of meiotic recombination shapes heredity and genetic divers

279 Meiotic recombination shapes the genetic diversity trans

280 Meiotic recombination shuffles genetic variation and pro

281 Our results show that meiotic recombination sites are localized away from PRDM

282 PRDM9 binding localizes almost all meiotic recombination sites in humans and mice.

283 Meiotic recombination starts with the formation of DNA d

284 Physical mapping methods independent of meiotic recombination, such as radiation hybrid (RH) map

285 igh intrachromosomal recombination is due to meiotic recombination, suggesting frequent outcrossing i

286 ce motifs that predict consistent, localized meiotic recombination suppression around a subset of PRD

287 and ubiquitin have antagonistic roles during meiotic recombination that are balanced to effect differ

288 the identification of a pioneer complex for meiotic recombination, this study broadens the conceptua

289 rge-scale variation in GC-content, caused by meiotic recombination, via the non-adaptive process of G

290 PRDM9 binding and its role in fertility and meiotic recombination, we humanized the DNA-binding doma

291 s for genes that encode proteins involved in meiotic recombination were altered, which suggested that

292 an integral part of a new regulatory step of meiotic recombination, which has implications to prevent

293 with quantitative traits, or fine mapping of meiotic recombination, which is a key determinant of gen

294 Genetic diversity in offspring is induced by meiotic recombination, which is initiated between homolo

295 itability and genome stability are shaped by meiotic recombination, which is initiated via hundreds o

296 Mammalian meiotic recombination, which preferentially occurs at sp

297 ) formed by the SPO11 transesterase initiate meiotic recombination, which promotes pairing and segreg

298 Our work reveals that condensin coordinates meiotic recombination with chromosome segregation at the

299 l, our findings further our understanding of meiotic recombination with implications for both basic a

300 We observe several instances of meiotic recombination within copy number variants associ