ライフサイエンスコーパス: melanocortin-4 receptor

1 -acetyl alpha-MSH successfully activated the melanocortin 4 receptor.

2 in the search for novel ligands of the human melanocortin 4 receptor.

3 highly mutated and well-established target, melanocortin 4 receptor.

4 independently of leptin, GLP-1 receptor and melanocortin 4 receptor.

5 than for the well-established obesity target melanocortin 4 receptor.

6 ium spiny neurons owing to activation of the melanocortin 4 receptor.

7 esting there is allosteric modulation of the melanocortin-4 receptor.

8 -alpha-MSH to cells overexpressing the human melanocortin-4 receptor.

9 for the melanocortin-3 receptor than for the melanocortin-4 receptor.

10 AGRP are functional antagonists of the human melanocortin-4 receptor.

11 tagonists of the melanocortin-3 receptor and melanocortin-4 receptor.

12 nist or micromolar agonist activities at the melanocortin-4 receptor.

13 cy of TCMCB07, a synthetic antagonist of the melanocortin-4 receptor.

14 sequent activation of central nervous system melanocortin 4 receptors.

15 binding affinity for both melanocortin-3 and melanocortin-4 receptors.

16 n energy control in rodents, notably via the melanocortin-4 receptor(1).

17 A potent and selective antagonist of the melanocortin-4 receptor, 1-[2-[(1S)-(3-dimethylaminoprop

18 e in regulating signaling and trafficking of melanocortin 4 receptor, a critical controller of energy

19 In 293T cells expressing the melanocortin 4 receptor, Act-alphaMSH is far more potent

20 lanocyte-stimulating hormone (alphaMSH) is a melanocortin 4 receptor agonist, and its potency in redu

21 iency were treated with setmelanotide, a new melanocortin-4 receptor agonist.

22 tion of body weight: PVN neurons express the melanocortin 4 receptor and appear to be physiological t

23 2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 sign

24 hrough the modulation of the activity of the melanocortin-4 receptor and prokineticin receptors.

25 The melanocortin pathway, specifically the melanocortin-4 receptor and the cognate endogenous agoni

26 Furthermore, the melanocortin-4 receptor antagonist SHU9119 partially inh

27 tions in the coding region of the serpentine Melanocortin 4 receptor are the most common genetic caus

28 ity for the melanocortin-3 receptor over the melanocortin-4 receptor are reported.

29 se can prevent the genetic predisposition of melanocortin-4 receptor-associated obesity and diabetes.

30 inity to the melanocortin 3 receptor and the melanocortin 4 receptor, but not to the melanocortin 1 r

31 leads to an increased number of monomers of melanocortin-4 receptor by disrupting receptor oligomers

32 e consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy

33 s and duplications) and a Mendelian disease (melanocortin 4 receptor deficiency (MC4R)) that affect B

34 Furthermore, the obesity induced by melanocortin 4 receptor deficiency also constricted the

35 characterized by excessive hunger, including melanocortin-4 receptor deficiency, that present with lo

36 not significantly altered in the ob, db, or melanocortin 4 receptor-deficient mouse model of obesity

37 d weight loss but not setmelanotide-induced (melanocortin-4 receptor-dependent) weight loss.

38 hypothalamus; the MSH normally then binds to melanocortin-4 receptor expressing neurons and inhibits

39 Within the PVH(SIM1) population, melanocortin-4 receptor-expressing (PVH(MC4R)) neurons a

40 Melanocortin-4 receptor-expressing neurons in the parave

41 Mutations in the melanocortin 4 receptor gene (MC4R) are associated with

42 Heterozygous coding mutations in the melanocortin 4 receptor gene (MC4R) are the most common

43 Mutations in the melanocortin-4 receptor gene (MC4R) represent the common

44 The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regul

45 harmacological blockade and knockdown of the melanocortin-4 receptor gene in the DMV abolish this sti

46 tively low affinity for binding at the human melanocortin 4 receptor (hMC4R), were prepared by solid

47 ed to introduce selectivity toward the human melanocortin 4 receptor (hMC4R).

48 Mutations of the human melanocortin-4 receptor (hMC4R) have been previously ide

49 ss biased UmBLs (BUmBLs) targeting the human melanocortin-4 receptor (hMC4R) were discovered.

50 This fusion protein bound to the human melanocortin-4 receptor (hMC4R) with an affinity similar

51 Specific interactions of human melanocortin-4 receptor (hMC4R) with its nonpeptide and

52 or the interaction of ligands with the human melanocortin-4 receptor (hMC4R), agonist structure-activ

53 ossibly acting upstream or downstream of the melanocortin 4 receptor in the PVN, is responsible for s

54 egulation of signaling by melanocortin 3 and melanocortin 4 receptors in the CNS is controlled via ne

55 t a role for the melanocortin system and the melanocortin-4 receptor in the ring dove feeding behavio

56 cy of TCMCB07, a synthetic antagonist of the melanocortin-4 receptor, in mitigating anorexia and weig

57 uggested these effects were mediated through melanocortin-4 receptor independent mechanisms.

58 Activation of melanocortin-4 receptors inhibits DMV cholinergic neuron

59 The melanocortin 4 receptor is involved in the control of th

60 In this regard, the melanocortin-4 receptor is a critical coordinator of mam

61 The melanocortin-4 receptor is a G protein-coupled receptor

62 essory protein 2 has multiple effects on the melanocortin-4 receptor: it enhances G protein-mediated

63 Male melanocortin 4 receptor knockout mice (MC4RKO) were pair

64 Importantly, CCl(4)-induced and melanocortin-4 receptor knockout mice on a western diet

65 derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonis

66 one (alpha-MSH) at melanocortin-3 (MC-3) and melanocortin-4 receptors (MC-4).

67 the interaction between leptin, insulin, and melanocortin-4 receptors (MC-4Rs) in the control of rena

68 The centrally expressed melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R, respectively) a

69 The centrally located melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are involved in th

70 The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators

71 that intraventricular administration of the melanocortin 4 receptor (MC4-R) agonist MT II and antago

72 Melanocortin 4 receptor (MC4-R) antagonists are actively

73 The melanocortin 4 receptor (MC4-R) plays a pivotal role in

74 Stimulation of the hypothalamic melanocortin 4 receptor (MC4-R) produces relative anorex

75 Activation of melanocortin 4 receptors (MC4-Rs) in brain nuclei associ

76 In this study, we characterize the rat melanocortin-4 receptor (MC4-R) and demonstrate that thi

77 The melanocortin-4 receptor (MC4-R) appears to be an importa

78 t genetic or pharmacological blockade of the melanocortin-4 receptor (MC4-R) attenuates uremia-associ

79 Inactivation of the melanocortin-4 receptor (MC4-R) by gene-targeting result

80 ays inverse agonism at constitutively active melanocortin-4 receptor (MC4-R) expressed on transfected

81 The melanocortin-4 receptor (MC4-R) is a G protein-coupled,

82 The melanocortin-4 receptor (MC4-R) is an important mediator

83 The melanocortin-4 receptor (MC4-R) is an important regulato

84 satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-indu

85 fluorescent protein under the control of the melanocortin-4 receptor (MC4-R) promoter, we observed Y1

86 de is also an antagonist of the hypothalamic melanocortin-4 receptor (MC4-R).

87 ceptors, melanocortin-3-receptor (MC3-R) and melanocortin-4-receptor (MC4-R), are expressed in many d

88 Melanocortin 4 receptor (MC4R) agonists have emerged as

89 C) at the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) and has been proposed to

90 Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, a

91 ons in the coding sequence of the serpentine melanocortin 4 receptor (MC4R) are the most frequent gen

92 Accordingly, exogenous stimulation of the melanocortin 4 receptor (Mc4r) by cotreating mice with F

93 oylglycerol (2-AG) regulates the activity of melanocortin 4 receptor (MC4R) cells in the paraventricu

94 es between patients with SIM1 deficiency and melanocortin 4 receptor (MC4R) deficiency suggest that s

95 Melanocortin 4 receptor (MC4R) deficiency, caused by mut

96 agouti peptide is a potent antagonist of the melanocortin 4 receptor (MC4R) expressed in neurons, and

97 Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obes

98 oding mutations in conserved residues of the melanocortin 4 receptor (MC4R) gene, contributing to the

99 This locus, near the melanocortin 4 receptor (MC4R) gene, overlaps a region p

100 rial who carried pathogenic mutations in the melanocortin 4 receptor (MC4R) gene, the most common gen

101 We show that Opn3 is coexpressed with the melanocortin 4 receptor (Mc4r) in a population of PVN ne

102 rosses the blood-brain barrier, binds to the melanocortin 4 receptor (MC4R) in the paraventricular an

103 The melanocortin 4 receptor (MC4R) is a G protein-coupled re

104 The melanocortin 4 receptor (MC4R) is a G-protein-coupled re

105 rease in hypothalamic oxytocin (Oxt) and PVN melanocortin 4 receptor (Mc4r) mRNA.

106 Melanocortin 4 receptor (MC4R) mutations are the most co

107 Here we report that melanocortin 4 receptor (MC4R) neurons located in the do

108 The melanocortin 4 receptor (MC4R) plays a critical role in

109 The melanocortin 4 receptor (MC4R) plays a role in energy ho

110 The melanocortin 4 receptor (MC4R) plays an important role i

111 Melanocortin 4 receptor (MC4R) plays an important role i

112 eavage and polyadenylation in the intronless melanocortin 4 receptor (MC4R) pre-mRNA.

113 dependent BMI-associated signals in BDNF and melanocortin 4 receptor (MC4R) regions.

114 Melanocortin 4 receptor (MC4R) regulates energy homeosta

115 Mutations in the melanocortin 4 receptor (MC4R) result in hyperphagia and

116 Loss of function of the melanocortin 4 receptor (MC4R) results in hyperphagia, o

117 ated whether the effect of GNAS mutations on melanocortin 4 receptor (MC4R) signaling explains the ob

118 Melanocortin 4 receptor (MC4R) signaling mediates divers

119 n suggests brain origin, whether the central melanocortin 4 receptor (Mc4r) system directly modulates

120 The central melanocortin system acts through melanocortin 4 receptor (MC4R) to control appetite, food

121 Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously imp

122 ed genetic deletion of the gene encoding the melanocortin 4 receptor (MC4R), as well as pharmacologic

123 and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the contro

124 dorsal raphe nucleus (dlDRN) expressing the melanocortin 4 receptor (MC4R), which in turn innervate

125 Signalling though the melanocortin 4 receptor (MC4R), which is widely expresse

126 sity (DIO), leptin receptor (LepR)-null, and melanocortin 4 receptor (MC4R)-null mice-in this study,

127 e was tested in a cell line expressing human melanocortin 4 receptor (MC4R).

128 Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of e

129 T), neuronal nitric oxide synthase 1 (NOS1), melanocortin 4-receptor (MC4R), prodynorphin (PDYN)).

130 icosities in close apposition to a subset of melanocortin-4 receptor (MC4R(PVH)) cells, which are als

131 yte stimulating hormones (alpha-MSH) and the melanocortin-4 receptor (Mc4r) all lead to obesity in ma

132 rgy homeostasis, with key components such as melanocortin-4 receptor (MC4R) and adenylyl cyclase 3 (A

133 Recent studies have demonstrated that melanocortin-4 receptor (MC4R) antagonists can prevent w

134 Loss-of-function mutations in the human melanocortin-4 receptor (MC4R) are associated with obesi

135 ings suggest that the proximal region of the melanocortin-4 receptor (MC4R) C terminus is crucial not

136 Melanocortin-4 receptor (MC4R) controls appetite and foo

137 Features of melanocortin-4 receptor (MC4R) deficiency have been obse

138 In the current study, we investigated melanocortin-4 receptor (MC4R) expression in the nodose

139 increased linear growth, mirroring Sim1 and Melanocortin-4 receptor (MC4R) haplo-insufficiency in mi

140 Melanocortin-4 receptor (MC4R) has an important regulato

141 The melanocortin-4 receptor (MC4R) has been broadly investig

142 The melanocortin-4 receptor (MC4R) has been studied extensiv

143 ly significant heterozygous mutations in the Melanocortin-4 receptor (MC4R) have been implicated in 2

144 We show here that absence of the melanocortin-4 receptor (MC4R) in mice causes dilated ca

145 The melanocortin-4 receptor (MC4R) in the hypothalamus is th

146 ological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of ener

147 The melanocortin-4 receptor (MC4R) is a centrally expressed,

148 Melanocortin-4 receptor (MC4R) is a G protein-coupled re

149 Melanocortin-4 receptor (MC4R) is a G protein-coupled re

150 The melanocortin-4 receptor (MC4R) is a G protein-coupled re

151 Melanocortin-4 receptor (MC4R) is a G protein-coupled re

152 The melanocortin-4 receptor (MC4R) is a G-protein coupled re

153 Melanocortin-4 receptor (MC4R) is a G-protein-coupled re

154 Melanocortin-4 receptor (MC4R) is a G-protein-coupled re

155 The melanocortin-4 receptor (MC4R) is a G-protein-coupled re

156 Melanocortin-4 receptor (MC4R) is critical for energy ho

157 The melanocortin-4 receptor (MC4R) is critically involved in

158 The melanocortin-4 receptor (MC4R) is essential for control

159 The melanocortin-4 receptor (MC4R) is involved in energy hom

160 The melanocortin-4 receptor (MC4R) is involved in energy hom

161 The melanocortin-4 receptor (MC4R) is involved in regulating

162 The melanocortin-4 receptor (MC4R) is well recognized as an

163 Melanocortin-4 receptor (MC4R) ligands are known to modu

164 een the antagonist AGRP amino acids with the melanocortin-4 receptor (MC4R) may be important for the

165 The melanocortin-4 receptor (MC4R) plays an important role i

166 Melanocortin-4 receptor (MC4R) plays critical roles in r

167 e resulted in the discovery of over 70 human melanocortin-4 receptor (MC4R) polymorphisms observed as

168 The Melanocortin-4 receptor (MC4R) regulates food intake, en

169 Haploinsufficiency of the melanocortin-4 receptor (MC4R) results in melanocortin o

170 TSK are induced by feeding and regulated by melanocortin-4 receptor (MC4R) signaling.

171 Surges in E2 increase melanocortin-4 receptor (MC4R) signalling in these VMHvl

172 Melanocortin-4 receptor (MC4R) SNPs have been associated

173 in (AGRP) is an endogenous antagonist of the melanocortin-4 receptor (MC4R) that functions in the hyp

174 tribution of extracytoplasmic domains of the melanocortin-4 receptor (MC4R) to AGRP binding by making

175 actors that mediate their action through the melanocortin-4 receptor (MC4R) whereas AGRP is an opposi

176 The melanocortin-4 receptor (MC4R), a centrally expressed G

177 ing these methods, we performed a DMS of the melanocortin-4 receptor (MC4R), a G-protein-coupled rece

178 The melanocortin-4 receptor (MC4R), a hypothalamic master re

179 The hypothalamic melanocortin-4 receptor (MC4R), a seven transmembrane G-

180 ct of exogenous alpha-MSH is mediated by the melanocortin-4 receptor (MC4R), and what thermoeffector

181 f AgRP are not limited to its actions at the melanocortin-4 receptor (MC4R), because MC4R-deficient (

182 to play an important role downstream of the melanocortin-4 receptor (MC4R), but this hypothesis has

183 hypothalamus (PVN) were shown to contain the melanocortin-4 receptor (MC4R), concentrated in the vent

184 Melanocortin-4 receptor (Mc4r)-expressing neurons in the

185 erge with GABAergic ARC(AgRP) projections on melanocortin-4 receptor (MC4R)-expressing satiety neuron

186 Melanocortin-4 receptor (Mc4r)-null mice exhibit late-on

187 ons containing the melanocortin-3 (MC3R) and melanocortin-4 receptor (MC4R).

188 the G93A SOD1 mutation that also lacked the melanocortin-4 receptor (MC4R).

189 ulates body energy homeostasis including the melanocortin-4 receptor (MC4R).

190 ssess single nucleotide polymorphisms in the melanocortin-4 receptor (MC4R).

191 d as potent and selective antagonists of the melanocortin-4 receptor (MC4R).

192 Both peptides bind with high affinity to the melanocortin-4 receptor (MC4R); existing data show that

193 Melanocortin-4 receptors (MC4R) have weight-independent

194 ing and satiety are coordinated centrally by melanocortin-4 receptors (MC4R) in neurons of the hypoth

195 istic actions of these ligands at downstream melanocortin-4 receptors (MC4R) in the paraventricular n

196 Melanocortin-4-receptor (MC4R) haploinsufficiency is the

197 Defects in melanocortin-4-receptor (MC4R) signalling result in hype

198 Melanocortin-4-receptor (MC4R)-expressing neurons modula

199 ake in rodents, presumably via activation of melanocortin-4-receptor (MC4R).

200 Disruption of hypothalamic melanocortin 4 receptors (MC4Rs) causes obesity in mice

201 Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic n

202 Melanocortin 4 receptors (MC4Rs) in the central nervous

203 Activation of brain melanocortin 4 receptors (MC4Rs) leads to reduced food i

204 Brain melanocortin 4 receptors (MC4Rs) regulate body weight an

205 Further, we found that deletion of melanocortin 4 receptors (MC4Rs), a downstream target of

206 Melanocortin-4 receptors (MC4Rs) are expressed by vagal

207 n supraoptic oxytocin neurons, and alpha-MSH melanocortin-4 receptors (MC4Rs) are highly expressed in

208 Activation of melanocortin-4 receptors (MC4Rs) restrains feeding and p

209 To a greater degree, they also contain melanocortin-4 receptors (MC4Rs), implying that leptin c

210 Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores

211 ral despair, are prevented by blocking these melanocortin 4 receptor-mediated synaptic changes in viv

212 tructural homology model of the active state melanocortin-4 receptor - melanocortin-receptor accessor

213 -3 receptor (mMC3R) antagonists and nM mouse melanocortin-4 receptor (mMC4R) agonists.

214 In vitro mutagenesis of the mouse melanocortin-4 receptor (mMC4R) has been performed, base

215 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the lea

216 does not suppress the obese phenotype of the melanocortin-4-receptor null allele or those of the mono

217 to moderately increased dietary fat content, melanocortin-4 receptor-null mutant (MC4R-/-) mice exhib

218 es not alter hypothalamic mRNA expression of melanocortin 4 receptor or adiponectin serum and mRNA ex

219 2) = 5.9) is also an antagonist at the brain melanocortin-4 receptor (pA(2) = 6.9), with no observabl

220 e central nervous system proopiomelanocortin-melanocortin 4 receptor pathway, and kidney compression

221 Binding data demonstrate that melanocortin 4 receptor responds to all chimeras and is

222 , body mass accrual and functional leptin or melanocortin-4 receptor signaling.

223 y protein that interacts with and influences melanocortin-4 receptor structure, biasing its signaling

224 downstream of hypothalamic and/or brainstem melanocortin 4 receptors, that project via the autonomic

225 Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obe

226 hingosine 1-phosphate receptor-3 (S1P3), the melanocortin-4 receptor, the Smoothened receptor, formyl

227 showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-li

228 POMC neurons and subsequent activation of melanocortin 4 receptors were critical for nicotinic-ind

229 of protease-activated receptors-1 and -2 and melanocortin-4 receptors yields agonists and/or antagoni