ライフサイエンスコーパス: melastatin

1 this leads to closure of the TRPM1 channel (melastatin).

2 icroRNA (miR-211) hosted within an intron of melastatin.

3 hannel, subfamily M, member 1, also known as melastatin.

4 arity to several vertebrate genes, including melastatin.

5 cascade and the transient receptor potential melastatin 1 (TRPM1) cation channel.

6 metabotropic glutamate receptor 6 to the TRP melastatin 1 (TRPM1) channel to transmit signals from ph

7 aining G(alphao), and the cation channel TRP melastatin 1 (TRPM1).

8 Go , closure of transient receptor potential melastatin 1 channels and hyperpolarization of these cel

9 ressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosph

10 Transient receptor potential melastatin-1 (TRPM1) is essential for the light-induced

11 try (SOCE), the transient receptor potential melastatin 2 (TRPM2) channel contributes to Ca(2+) relea

12 try through the transient receptor potential melastatin 2 (TRPM2) channel in macrophages.

13 Transient receptor potential melastatin 2 (TRPM2) channel is known to be a cellular r

14 The transient receptor potential melastatin 2 (TRPM2) channel plays a key role in redox s

15 neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced

16 cation channel transient receptor potential melastatin 2 (TRPM2) exhibit essential roles in FPP-indu

17 variant of the transient receptor potential melastatin 2 (TRPM2) gene may confer susceptibility to t

18 cation channel transient receptor potential melastatin 2 (TRPM2) in a murine model of kidney ischemi

19 Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential functi

20 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channe

21 Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channe

22 Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable channel gated

23 Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable channel acti

24 Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for t

25 Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and h

26 cation channel transient receptor potential melastatin 2 (TRPM2) plays a key role in pathogen-evoked

27 rmeable channel Transient Receptor Potential Melastatin 2 (TRPM2).

28 tella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosi

29 The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important

30 DP ribose opens transient receptor potential melastatin-2 (TRPM2) channels in endothelial cells leadi

31 Transient Receptor Potential Melastatin-2 (TRPM2) ion channel is emerging as a great

32 ble ion channel transient receptor potential melastatin-2 (TRPM2), previously implicated in persisten

33 TIONALE: TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a

34 ent receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) are transduction channels of sensor

35 ent receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) are transduction channels of sensor

36 (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clea

37 Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and

38 Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca(2+) permeable non-selective

39 Transient receptor potential melastatin 3 (TRPM3) is a calcium-permeable nonselective

40 Transient receptor potential melastatin 3 (TRPM3) is a heat-activated ion channel exp

41 Transient receptor potential melastatin 3 (TRPM3) is a nonselective cation channel th

42 Transient receptor potential melastatin 3 ion channel (TRPM3) belongs to the TRP fami

43 stimulation of transient receptor potential melastatin-3 (TRPM3) channels.

44 urea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) cation channel is a key underl

45 e non-selective Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expres

46 d K(+) (BK) and transient receptor potential melastatin 4 (TRPM4) cation channels linked to disruptio

47 The transient receptor potential melastatin 4 (TRPM4) channel contributes to disease seve

48 ive deletion of transient receptor potential melastatin 4 (TRPM4) channels in mouse cardiomyocytes re

49 x through transient receptor potential (TRP) melastatin 4 (TRPM4) channels to cause membrane depolari

50 ltage-dependent transient receptor potential melastatin 4 (TRPM4) channels.

51 Transient receptor potential melastatin 4 (TRPM4) is a Ca(2+) -activated nonselective

52 Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation channe

53 dently enhances transient receptor potential melastatin 4 (TRPM4), a Ca2+-activated nonselective (CAN

54 bly of Sur1 and transient receptor potential melastatin 4 (Trpm4).

55 )1.6, and transient receptor potential [TRP] melastatin 4 [TRPM4]) both regulate excitability and gen

56 Transient receptor potential (TRP) melastatin 4 and 5 (TRPM4 and TRPM5), two calcium-activa

57 ucted by TRPM4 (transient receptor potential melastatin 4) channels in native cerebral artery smooth

58 a-gustducin and transient receptor potential melastatin 5.

59 n and restoring transient receptor potential melastatin 6 expression in the DCT.

60 n, and restored transient receptor potential melastatin 6 expression.

61 gnesium channel transient receptor potential melastatin 6, and NCC phosphorylation, all of which were

62 tivation of the transient receptor potential melastatin 7 (TRPM7) channel promotes extracellular calc

63 (2+) conducting transient receptor potential melastatin 7 (TRPM7) channel-enzyme (chanzyme) has been

64 n activates the transient receptor potential melastatin 7 (TRPM7) channel.

65 Transient receptor potential melastatin 7 (TRPM7) channels are novel Ca(2+)-permeable

66 n DIO acting on transient receptor potential melastatin 7 (Trpm7) channels in CB.

67 Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnes

68 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containin

69 Transient receptor potential melastatin 7 (TRPM7) is a broadly expressed, non-selecti

70 Transient receptor potential melastatin 7 (TRPM7) is a divalent ion channel with a C-

71 Transient receptor potential melastatin 7 (TRPM7) is a newly found gene essential to

72 ABSTRACT: The transient receptor potential melastatin 7 (TRPM7) is a protein that combines an ion c

73 Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed Mg(2+)-

74 r inhibition of transient receptor potential melastatin 7 (TRPM7) reduces store-operated calcium entr

75 re we show that Transient Receptor Potential Melastatin 7 (TRPM7), a divalent-permeant channel-kinase

76 ous variants in transient receptor potential melastatin 7 (TRPM7), a ubiquitously expressed ion chann

77 e find that the transient receptor potential melastatin 7 (TRPM7)-associated Mg2+ -inhibited cation (

78 of MSCs through Transient receptor potential melastatin 7 (TRPM7)-Osterix axis.

79 ermeable TRPM7 (transient receptor potential melastatin 7) channels.

80 TRPM7 (transient-receptor-potential melastatin 7) is an ion channel with alpha-kinase functi

81 enthol receptor transient receptor potential melastatin 8 (TRPM8) and compared its behavior with that

82 Transient receptor potential melastatin 8 (TRPM8) and transient receptor potential va

83 l ganglion, the transient receptor potential melastatin 8 (TRPM8) channel is a Ca(2+)-permeable catio

84 nthol-sensitive transient receptor potential melastatin 8 (TRPM8) channel is important for both physi

85 The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular tr

86 nthol-activated transient receptor potential melastatin 8 (TRPM8) channels are thought to be regulate

87 Transient receptor potential melastatin 8 (TRPM8) channels are well known as sensors

88 nthol-activated transient receptor potential melastatin 8 (TRPM8) channels diminishes over time in th

89 nthol-activated transient receptor potential melastatin 8 (TRPM8) channels.

90 The transient receptor potential melastatin 8 (TRPM8) ion channel is a major sensor of en

91 The transient receptor potential melastatin 8 (TRPM8) ion channel is a major sensor of en

92 The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector

93 Transient receptor potential melastatin 8 (TRPM8) ion channel represents a valuable p

94 interacts with transient receptor potential melastatin 8 (TRPM8) ion channels in cold-sensitive sens

95 nthol-sensitive transient receptor potential melastatin 8 (TRPM8) ion channels.

96 Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel ex

97 Transient receptor potential melastatin 8 (TRPM8) is a temperature- and menthol-sensi

98 Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modul

99 One such channel--TRP melastatin 8 (TRPM8) or cold and menthol receptor 1 (CMR

100 is detected by transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel expr

101 nthol activates transient receptor potential melastatin 8 (TRPM8), an ion channel also activated by c

102 aling receptor, Transient Receptor Potential Melastatin 8 (TRPM8), regulates dimorphic sexual and soc

103 hibited robust, transient receptor potential melastatin 8 (TRPM8)-dependent discharges at room temper

104 enthol receptor transient receptor potential melastatin 8 (TRPM8).

105 d-gated channel transient receptor potential melastatin 8 (TRPM8).

106 vanilloid 1 and transient receptor potential melastatin 8 in sensory neurons and causes mechanical hy

107 receptor TRPM8 (transient receptor potential melastatin 8) has been suggested to play a role in cold

108 vanilloid 1 and transient receptor potential melastatin 8) in primary sensory neurons using both phar

109 receptor TRPM8 (transient receptor potential melastatin 8) on trigeminal afferents.

110 pport a role of transient receptor potential melastatin 8-mediated facilitation of synaptic strength

111 sitive channel transient receptor potential (melastatin)-8 (TRPM8), heterologously expressed in Chine

112 port that human transient receptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8

113 ll-length human transient receptor potential melastatin-8 (TRPM8) but did not inhibit activation by m

114 In the same experimental setup, blocking the melastatin-8 (TRPM8) channel with AMG2850 (30 mg/kg) att

115 imation via the transient receptor potential melastatin-8 (TRPM8) channel without evoking nociceptive

116 tagonist of the transient receptor potential melastatin-8 (TRPM8) channel.

117 Transient Receptor Potential Melastatin-8 (TRPM8), a recently identified member of th

118 diesel exhaust PM > crystalline silica; TRP melastatin-8 is also robustly activated by CFA1, whereas

119 man melanomas characterized by low levels of melastatin and miR-211.

120 further divided into TRPC (canonical), TRPM (melastatin), and TRPV (vanilloid) subfamilies.

121 umor suppressive activity is not mediated by melastatin but instead by a microRNA (miR-211) hosted wi

122 Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an ess

123 The TRP melastatin channels TRPM2 and TRPM3 have a role in pain

124 human primary cutaneous melanomas examined, melastatin expression appeared to correlate inversely wi

125 ssion pattern observed suggests that loss of melastatin expression is an indicator of melanoma aggres

126 n, whereas primary melanomas showed variable melastatin expression.

127 dermal transient receptor potential channel, melastatin family (TRPM) channel GTL-2 and IP(3)R-stimul

128 belongs to the Transient Receptor Potential Melastatin family of ion channels and is a divalent cati

129 The melastatin-family transient receptor potential 2 (TRPM2)

130 The mouse melastatin gene contains 27 exons and spans at least 58

131 r via the TRPM (transient receptor potential melastatin) gene, GON-2, which may sense the intestinal

132 PZQ activates a transient receptor potential melastatin ion channel (TRPM(PZQ)) in schistosomes by en

133 a member of the Transient-Receptor-Potential Melastatin ion channel family.

134 Melastatin is greatly downregulated in metastatic melano

135 lcium-permeable channel, transient potential melastatin-like 2 (TRPM2), via stimulation of poly-ADP-r

136 We found that transient receptor potential-melastatin-like 7 (TRPM7) channel expression regulated E

137 The gene transient receptor potential-melastatin-like 7 (Trpm7) encodes a protein that functio

138 l disruption of transient receptor potential-melastatin-like 7 (Trpm7) in mice results in embryonic l

139 Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also

140 Transient receptor potential melastatin-like 7 channel (TRPM7) is a ubiquitous, const

141 lected against via suppression of the entire melastatin locus during human melanoma progression.

142 ate was 90% +/- 7%, whereas in patients with melastatin loss, the disease-free survival rate was 51%

143 A was 100%, whereas in stage I patients with melastatin loss, the disease-free survival rate was 77%

144 sion criterion, TRP polycystic (P)3, and TPR melastatin (M)8 were found to be uniquely adipospecific.

145 Transient receptor potential melastatin member 4 (TRPM4) channels are nonselective mo

146 reen identified transient receptor potential melastatin member 4 (TRPM4), a calcium-activated, ATP-in

147 The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are div

148 Transient receptor potential melastatin member 8 (TRPM8) is a calcium ion (Ca(2+))-pe

149 Transient receptor potential (TRP) melastatin member 8 (TRPM8), which is a calcium-permeabl

150 ceptor potential cation channel subfamily M (melastatin) member 8 play a crucial role.

151 amily includes the putative tumor suppressor melastatin (MLSN) and is a poorly characterized group of

152 Melastatin (MLSN-1), a novel melanocyte-specific gene re

153 Uniform melastatin mRNA expression in the primary tumor was corr

154 erformed to assess the prognostic utility of melastatin mRNA expression while adjusting for other pro

155 udied the relationship between expression of melastatin mRNA in the primary cutaneous tumor and progn

156 Downregulation of melastatin mRNA in the primary cutaneous tumor is a prog

157 I patients whose tumors diffusely expressed melastatin mRNA was 100%, whereas in stage I patients wi

158 Melastatin mRNA was evaluated by in situ hybridization i

159 II disease whose tumors diffusely expressed melastatin mRNA, the 8-year disease-free survival rate w

160 the mouse are consistent with involvement of melastatin mutations in the mouse ruby-eye-2 defect, con

161 terminus domain (CTD) of the cold-activated melastatin receptor channel, TRPM8.

162 Increasing expression of miR-211 but not melastatin reduced migration and invasion of malignant a

163 that the transient receptor potential (TRP) melastatin related 7 (TRPM7) is the molecular basis of t

164 a member of the transient receptor potential melastatin-related (TRPM) family of cation channels, whi

165 The transient receptor potential melastatin-related channel 2 (TRPM2) is a nonselective c

166 cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) c

167 ium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) i

168 TRPM6 and TRPM7 are members of the melastatin-related transient receptor potential (TRPM) s

169 Melastatin-related transient receptor potential channel

170 The melastatin-related transient receptor potential channel

171 variants in the transient receptor potential melastatin-related type 3 gene (TRPM3) have been associa

172 Used in combination, melastatin status and tumor thickness allow for the iden

173 Multivariate analysis revealed that melastatin status, mitotic rate, and tumor thickness inf

174 nsient receptor potential ion channel in the melastatin subfamily (TRPM(PZQ))-however, little is know

175 The melastatin subfamily (TRPM) channels have N-terminal dom

176 , inhibitors of transient receptor potential melastatin subfamily 4 (TRPM4), intracellular introducti

177 rent carried by transient receptor potential melastatin subfamily 4 channels via type 2 inositol 1,4,

178 mate receptor 6/transient receptor potential melastatin subfamily M member 1-signaling (mGluR6/TRPM1-

179 et identified within the S1-S4 domain of the Melastatin subfamily member TRPM8, the mammalian sensor

180 The melastatin subfamily of the transient receptor potential

181 nsient receptor potential ion channel of the melastatin subfamily, named TRPM(MCLZ), as a parasite ta

182 nsient receptor potential ion channel of the melastatin subfamily, TRPM8, is a major cold receptor in

183 The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously

184 his analysis identified a novel gene, termed melastatin, that is expressed at high levels in poorly m

185 Melastatin transcripts were not detected in melanoma met

186 cation channel transient receptor potential melastatin (TRPM) 4 is involved in the control of Ca(2+)

187 lycosylation of transient receptor potential melastatin (Trpm) 4b, a membrane glycoprotein that regul

188 Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors

189 Finally, two transient receptor potential melastatin (TRPM) channels, GON-2 and GTL-2, mediate thi

190 The TRP-melastatin (TRPM) subfamily includes the putative tumor

191 The transient receptor potential melastatin (TRPM) tetrameric cation channels are involve

192 amilies: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP),

193 The transient receptor potential melastatin (TRPM)-3 channel is critical for various phys

194 h in turn opens transient receptor potential melastatin (TRPM)2 channels.

195 studies have demonstrated that expression of melastatin/TRPM1 strongly predicts nonmetastatic propens

196 The transient receptor potential melastatin type 6 (TRPM6) epithelial Mg(2+) channels par

197 Mg(2+) channel transient receptor potential melastatin type 6 that determines the final urinary Mg(2

198 sensors such as transient receptor potential melastatin type 8 (TRPM8) have been identified, the neur

199 The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation chann

200 dulation of the transient receptor potential melastatin type 8 (TRPM8) is currently under investigati

201 Melastatin was also found to be differentially expressed

202 Benign nevi express high levels of melastatin, whereas primary melanomas showed variable me

203 We recently described a novel gene, melastatin, whose expression is inversely correlated wit