ライフサイエンスコーパス: melatonin

1 in drug metabolism/degradation (nicotine and melatonin).

2 us which regulates the rhythmic secretion of melatonin.

3 without affecting neuroprotective effects of melatonin.

4 tamoxifen usage alone due to the presence of melatonin.

5 educed cholesterol and elevated dopamine and melatonin.

6 vincristine, and prednisone, with or without melatonin.

7 acental communication via the pineal hormone melatonin.

8 and inflammation, all inhibited by exogenous melatonin.

9 kidneys and the therapeutic effectiveness of melatonin.

10 n lysates of animals previously treated with melatonin.

11 nd neurodegeneration, a process modulated by melatonin.

12 ad protected >80% of the active structure of melatonin.

13 the range of 1.63-4.68 mg/100g d.w. and for melatonin 0.43-0.64 mg/100g d.w.

14 o understand the influence of foliar applied melatonin (0, 50, 100, 150 and 200 muM) on two Salvia sp

15 Oral melatonin (10 mg) or placebo for up to seven consecutive

16 terward, following the removal of ligatures, melatonin (10 mg/body weight) to Ep-Mel group, and vehic

17 Then melatonin (10 mg/kg body weight/day, 14 days), and the v

18 ists, including 21 and a close derivative of melatonin, 28, had dramatically reduced arrestin recruit

19 oval of pineal gland) before and after daily melatonin (3 mg) replacement for 3 months.

20 Melatonin, 3 mg/d, or placebo for 4 weeks followed by a

21 Melatonin, a pineal hormone synthesized at night, is cri

22 study, we document that chloroplasts produce melatonin, a recently-discovered plant antioxidant molec

23 collection of a 24-hr time series of plasma melatonin, a suprachiasmatic nucleus-driven pineal hormo

24 igands of 34 serotonin, dopamine, histamine, melatonin, acetylcholine, and adrenergic receptors.

25 Maternal melatonin acts on the fetal PT to control expression of

26 apeutic effects of prolonged dark therapy or melatonin administration on hepatic fibrosis in the mult

27 ies of early morning bright light or evening melatonin agonists have found improved rates of delirium

28 Evidence for benzodiazepine hypnotics, melatonin agonists, and antidepressants, and for most ph

29 Foliar application of melatonin alleviated the oxidative stress by increasing

30 Melatonin also has sleep-inducing and anti-inflammatory

31 Circadian outputs were melatonin amplitude (overnight urinary 6-sulfatoxymelato

32 Melatonin amplitude and acrophase timing were generally

33 Melatonin, an endogenous free radical scavenger synthesi

34 constant light, (2) exogenous delivery of a melatonin analog under inhibitory constant light conditi

35 onists: the insomnia drug ramelteon(11), two melatonin analogues, and the mixed melatonin-serotonin a

36 n increases the expression of Bmal1 and both melatonin and Bmal1 increase cellular survival after oxy

37 ng pathway components, we revealed that both melatonin and Bmal1 increased phosphorylation of AKT, ER

38 Moreover, animals co-injected with melatonin and cisplatin did not display any significant

39 Melatonin and corticosterone concentrations were signifi

40 Circulating melatonin and corticosterone, and mRNA expression levels

41 against sleep-loss decrements in alertness, melatonin and cortisol profile, skin temperature and wri

42 Subjective sleepiness, melatonin and cortisol were assessed hourly.

43 and sleepiness, master clock markers (plasma melatonin and cortisol), plasma triglycerides, or clock

44 ning can strongly suppress the production of melatonin and delay our circadian rhythm.

45 erences in the circadian amplitude of plasma melatonin and electroencephalographic slow-wave activity

46 al programming of brain function by maternal melatonin and establish TSH signal transduction as a key

47 Melatonin and its derivatives also stimulated the expres

48 Thus, melatonin and its derivatives can serve as excellent pro

49 Melatonin and its metabolites enhanced the DNA repair in

50 In conclusion, melatonin and its metabolites protect melanocytes from U

51 e), and circadian rhythms (profiles of serum melatonin and its urinary metabolite 6-sulphatoxymelaton

52 About 45.8% and 34.4% of participants in the melatonin and placebo groups had very good sleep (risk r

53 esentation of genes from pathways related to melatonin and polo-like kinase in babies with adverse ou

54 Melatonin and serotonin are bioactive compounds present

55 and to understand the relationships between melatonin and the stress-associated phytohormones at mol

56 al skewed baseline cosine curve was used for melatonin, and acrophase of the cosine curve for aMT6s.

57 opioid, monoaminergic, orexinergic, immune, melatonin, and endocannabinoid systems; the hypothalamus

58 Articles relevant to circadian rhythms, melatonin, and light in the critically ill were selected

59 While clonazepam and melatonin are most commonly used as symptomatic treatmen

60 nuclear transfer (SCNT) embryos, and to test melatonin as a protective agent against electrofusion da

61 All these results point to melatonin as one of the main modulators of the changes i

62 Circadian release of melatonin at night from the pineal gland activates melat

63 the WG diet than after the RG diet, whereas melatonin, betaine, creatine, acetylcholine, aspartate,

64 nisms in midshipman is mediated, in part, by melatonin binding in vocal, auditory, and neuroendocrine

65 e-aged and old CBA mice, a strain capable of melatonin biosynthesis, to investigate naturally-occurri

66 sible pleiotropic physiological functions of melatonin, but instrumental variable effect estimates we

67 losed eyelids at levels that do not suppress melatonin can be used to mitigate sleep inertia upon wak

68 These results provide a mechanism by which melatonin can control pituitary function in a seasonal m

69 These results indicate that melatonin can have a strong effect on membrane structure

70 red/liquid-ordered phase separation and that melatonin can induce phase separation in these ternary m

71 numerous drugs and natural compounds such as melatonin, chloroquine, imiquimod, resveratrol, piceatan

72 Melatonin concentration-dependently activated G(q) prote

73 chain order as a function of temperature and melatonin concentration.

74 Flashes did not change melatonin concentrations or alertness in an ISI-dependen

75 PolyRad and free melatonin (control) were irradiated by UV light after be

76 Our data demonstrate that melatonin controls the expression of Bmal1 via PI3K/AKT

77 Circadian phase and amplitude of melatonin, cortisol, ghrelin, leptin, and glucose were n

78 6-hydroxymelatonin, a metabolite of melatonin, could not prevent follicle destruction, imply

79 knowledge, to evaluate BAT in patients with melatonin deficiency (radiotherapy or surgical removal o

80 improves blood lipid levels in patients with melatonin deficiency, suggesting that melatonin is a pos

81 rain and primary cerebro-cortical neurons of melatonin-deficient aralkylamine N-acetyltransferase (AA

82 we investigate neuroanatomical substrates of melatonin-dependent vocal-acoustic behavior in the noctu

83 l variations as well as differences in [(3)H]melatonin dissociation kinetics that provide insights in

84 prevent follicle destruction, implying that melatonin does not confer the protection of ovarian foll

85 Increased melatonin due to the highly-expressed MzASMT9 resulted i

86 Five out of the seven strains formed Melatonin during the fermentation process: three S. cere

87 irradiation showed >98% active structures of melatonin encapsulated in PolyRads.

88 applications for the genetic enhancement of melatonin-enriched plants for increasing crop production

89 rol, experimental periodontitis (Ep), and Ep-melatonin (Ep-Mel).

90 Also, strawberry fruits treated with melatonin exhibited higher gamma-aminobutyric acid trans

91 nd in North American homes will not suppress melatonin for durations up to 3 h, whereas extended use

92 ons associated with COVID-19 and identifying melatonin for potential prevention and treatment of COVI

93 study's objective was to assess if 18 mg/kg melatonin given rapidly over 2 h at 1 h after hypoxia-is

94 re 150 pg/mL (range, 125-2,125 pg/mL) in the melatonin group and 32.5 pg/mL (range, 18.5-35 pg/mL) in

95 eep quality was assessed to be better in the melatonin group than that in the placebo group with a me

96 This effect of melatonin has been previously studied in simple model bi

97 In particular, melatonin heightened GSH content as well as the ratio of

98 5% ethanol vehicle (HT+V; n = 7); (iii) HT + Melatonin (HT+M; n = 7).

99 Melatonin hypersecretion was observed in patients expose

100 long with modulating antioxidant metabolism, melatonin improves fruit quality traits by triggering a

101 fed to purified chloroplasts, they produced melatonin in a dose-response manner.

102 Understanding the role of melatonin in citrus defense to HLB may provide a novel t

103 roaches to investigate the potential role of melatonin in citrus response against HLB and to understa

104 nd water movement may underlie the effect of melatonin in delaying weight loss.

105 o elucidate whether the synthetic pathway of Melatonin in Saccharomyces and non-Saccharomyces strains

106 g enzymes for the production of dopamine and melatonin in the brain.

107 How melatonin in the PT controls the PD is not understood.

108 Here we observed that melatonin increases the expression of Bmal1 and both mel

109 The time-dependent, melatonin-induced differential expression of VEGF-A isof

110 Melatonin induces overexpression of genes related to ant

111 er effect than did infestation with D. citri Melatonin induction was positively correlated with salic

112 Melatonin is a neurohormone involved in the regulation o

113 s with melatonin deficiency, suggesting that melatonin is a possible BAT activator.

114 Melatonin is a small membrane-active molecule that has b

115 siaticus and transmitted by Diaphorina citri Melatonin is a ubiquitously distributed auxin-like metab

116 Melatonin is an important pineal gland hormone that has

117 Melatonin is formed in the pineal gland in a light-regul

118 hodopus sungorus), the programming effect of melatonin is mediated by the pars tuberalis (PT) of the

119 Over-the-counter melatonin is widely used to alleviate jet lag and as a s

120 this study we report that dopamine, but not melatonin, is responsible for entrainment of the PER2::L

121 ically-expressing MzASMT9 possessed improved melatonin level.

122 Therapeutic melatonin levels (15-30mg/l) were achieved at 2 h and we

123 a substantially longer duration of elevated melatonin levels (41 min) and delayed circadian phase of

124 Nighttime surges in melatonin levels activate melatonin receptors, which syn

125 elatonin, Mdr2(-/-) mice show elevated serum melatonin levels and inhibition of biliary mass, along w

126 We proposed that insufficient melatonin levels impair mitochondrial homeostasis, resul

127 festation significantly increased endogenous melatonin levels in Valencia sweet orange leaves and upr

128 Plasma melatonin levels show expected increase at night.

129 Melatonin levels were determined by enzyme-linked immuno

130 Melatonin levels, biliary mass, liver fibrosis, angiogen

131 reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine der

132 Bare melatonin lost ~80% of the active structure of the drug

133 k, or its output signals (e.g., dopamine and melatonin), may contribute to eye disease and pathology.

134 er exposure to darkness or administration of melatonin, Mdr2(-/-) mice show elevated serum melatonin

135 ed on either core body temperature or plasma melatonin measurements, as compared to non-carriers (by

136 ndings provide a better understanding of the melatonin-mediated defensive response against HLB via mo

137 neuroprotective agents (dexamethasone (DX), melatonin (MEL) and coenzyme Q10 (CoQ10)) in a single fo

138 t biomolecules such as norepinephrine (NEP), melatonin (MEL) and nicotine (NIC) in 0.1 M phosphate bu

139 The discovery of melatonin (Mel) in wines triggered a new interest in the

140 Melatonin (Mel) promotes sleep through G protein-coupled

141 rameters as measured by actigraphy and urine melatonin metabolite did not vary by group.

142 ctigraphy (motion-based) and morning urinary melatonin metabolite.

143 Melatonin might be regarded as an important supportive t

144 hin the infected leaves, which suggests that melatonin might play an antibacterial role against this

145 Dark therapy or targeting melatonin/miR-200b axis may be important in the manageme

146 rint of heteromers composed of G(i) -coupled melatonin MT(2) receptors and G(q) -coupled serotonin 5-

147 amine D2, histamine H1 and H2, melanocortin, melatonin, muscarinic M1 and M3, neurokinin, opioid KOP

148 Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormo

149 Melatonin, non-radiated PolyRad and irradiated PolyRad i

150 in) and delayed circadian phase of dim-light melatonin offset (1.37 h), partially mediated through de

151 predict the circadian rhythm of (i) salivary melatonin on a fixed sleep schedule; (ii) urinary aMT6s

152 the impact of 0, 1, 10, 100 and 1000mumol/L melatonin on attenuating fungal decay and maintaining nu

153 decreased Bmal1 expression and the effect of melatonin on Bmal1 after both OGD in vitro and focal cer

154 e used (2)H-NMR to investigate the effect of melatonin on the phase behavior of 1,2-dipalmitoyl-sn-gl

155 cular tissue and the therapeutic activity of melatonin on these effects.

156 ation of these proteins, which the effect of melatonin on these signaling molecules was not affected

157 An effect of melatonin on total soluble solids and lower respiration

158 osure were assessed using salivary dim-light melatonin onset (DLMO) and wrist-worn photometry, respec

159 toxymelatonin (aMT6s)) and timing (dim light melatonin onset (DLMO)), and evening salivary cortisol l

160 eep efficiency and exhibited later dim light melatonin onset phase than females, whereas females exhi

161 d that the timing of food intake relative to melatonin onset was significantly associated with the pe

162 sleep and circadian function were assessed (melatonin onset, actigraphy, and sleep diaries) in an ec

163 sumed most of their calories 1.1 h closer to melatonin onset, which heralds the beginning of the biol

164 0, 30, and 50 lux resulted in later apparent melatonin onsets by 22, 77, and 109 min, respectively.

165 MT2) did not change the activities of either melatonin or its derivatives.

166 ion, which was reduced in cells treated with melatonin or its metabolites: 6-hydroxymelatonin (6-OHM)

167 Forty-eight children were randomized 1:1 to melatonin or placebo treatment, and 38 of these (79%) co

168 val and retinal health is in part reliant on melatonin orchestration of circadian homeostatic activit

169 a fixed sleep schedule, the model predicted melatonin phase to within +/- 1 hour in 67% and +/- 1.5

170 ivariate whole-blood mRNA-based predictor of melatonin phase which requires few samples.

171 but not with DPPC-d(62), whereas at 10 mol% melatonin, phase separation was observed in both samples

172 Melatonin plays a central role in entraining activity to

173 Melatonin-PLGA-PLL-Trolox nanoparticle as named as PolyR

174 iability of melatonin, PolyRad alone without melatonin (PolyRad carrier control), non-radiated PolyRa

175 Cell viability of melatonin, PolyRad alone without melatonin (PolyRad carr

176 etabolism between diets, with kynurenine and melatonin positively associated with serum C-reactive pr

177 clear delineation of serotonergic areas and melatonin-producing pineal gland in rat brains.

178 re the fetal circadian system and autonomous melatonin production is established.

179 allele may extend the duration of endogenous melatonin production later into the morning and that ear

180 ysregulation of both sleep-wake behavior and melatonin production strongly suggests impaired non-visu

181 Assessment, and central circadian rhythm by melatonin profile.

182 melatonin when applied alone but blocked the melatonin-promoted G(q) activation due to its 5-HT(2C) a

183 may provide some clues to understanding how melatonin protects against Abeta, and that choice of cha

184 that a small deletion mutation of the Mel1a melatonin receptor (mtnr1a) gene causes a loss of rod ph

185 iability, migration, and binding affinity to melatonin receptor 1 (MT1R) and estrogen receptor 1 (ESR

186 ifferentially methylated CpG site within the melatonin receptor 1A (MTNR1A) gene mediates the effect

187 The T2D risk variant in the melatonin receptor 1B gene (MTNR1B) predicted risk of PO

188 ell as the duration of single calls, and (3) melatonin receptor 1b is highly expressed in evolutionar

189 ity of our previous 5-HT2C agonists with the melatonin receptor agonist tasimelteon and the putative

190 illustrates the opportunities for modulating melatonin receptor biology through MT(1)-selective ligan

191 reviously found a differential impairment of melatonin receptor signaling in AIS osteoblasts allowing

192 ould accordingly envisage that disruption of melatonin receptor signaling is detrimental to photorece

193 RNA distribution and transcript abundance of melatonin receptor subtype 1B (mel1b), shown to be impor

194 s contribute to a molecular understanding of melatonin receptor subtype selectivity and ligand access

195 rovide insights into the selectivity between melatonin receptor subtypes.

196 cadian signaling, conveyed through a mutated melatonin receptor, is incompatible with rod photorecept

197 ive effects of melatonin, while the membrane melatonin receptors (MT1 or MT2) did not change the acti

198 Melatonin receptors are expressed in several cell types

199 in the pars distalis (PD) of the pituitary, melatonin receptors are localized in the pars tuberalis

200 nin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of th

201 Melatonin receptors MT(1) and MT(2) are involved in sync

202 The human MT(1) and MT(2) melatonin receptors(1,2) are G-protein-coupled receptors

203 olecular foundation of ligand recognition by melatonin receptors, and will facilitate the design of f

204 ighttime surges in melatonin levels activate melatonin receptors, which synchronize cellular activiti

205 pendent of an effect on the classic membrane melatonin receptors.

206 LNs for a community containing serotonin and melatonin receptors.

207 Melatonin recovery occurred more slowly between IBL stim

208 pigenetic state, and caused ER stress, while melatonin reduced this damage.

209 raction with intracellular proteins, and how melatonin regulates its expression is largely unclear.

210 ssessed their body composition and timing of melatonin release during an in-laboratory assessment.Non

211 In contrast, in the BS, melatonin releases antiangiogenic VEGF-Axxxb from the PT

212 The present results show that oral melatonin replacement increases BAT volume and activity

213 Melatonin restricts the periodontitis-induced inflammato

214 uring the circadian acrophase of the urinary melatonin rhythm led to poorer outcomes on the KSS and P

215 rhythms and loss of phase coherence with the melatonin rhythm.

216 rk model was previously developed to predict melatonin rhythms accurately from blue light and skin te

217 s the only factor associated with changes in melatonin rhythms between days 1 and 2.

218 the primary factors contributing to abnormal melatonin rhythms.

219 ms showed no detectable phase coherence with melatonin rhythms.

220 t in birds and mammals that is indicative of melatonin's broad involvement in the modulation of physi

221 vocalizers and provide a striking example of melatonin's niche-specific functions.

222 Melatonin's receptors show higher expression in dioestru

223 findings, together with those in birds, show melatonin's remarkable versatility as a timing signal in

224 Our findings support the hypothesis that melatonin's stimulatory effects on vocal-acoustic mechan

225 ed by continuous wrist actigraphy, and serum melatonin sampled every 2 hours along with whole blood f

226 .e., photoperiod), encoded by the pattern of melatonin secretion from the pineal gland.

227 and the central circadian rhythm-controlled melatonin secretion profile.

228 son's disease (PD) and include disruption of melatonin secretion, disturbances of glucose, insulin re

229 he MTNR1B risk allele influences dynamics of melatonin secretion, generating a novel hypothesis that

230 sent SERS measurements of neurotransmitters (melatonin, serotonin, and epinephrine) at various concen

231 (11), two melatonin analogues, and the mixed melatonin-serotonin antidepressant agomelatine(12,13).

232 Melatonin serum peak levels at 2 AM were 150 pg/mL (rang

233 idate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to b

234 Conversely, long-duration melatonin signals on short photoperiods induce circadian

235 Systemically administered melatonin significantly decreased ABL in the STZ+L+Mel g

236 ers were the highest in the STZ+L group, and melatonin significantly decreased osteoclast numbers (P

237 microcomputed tomographic slices showed that melatonin significantly limits the ligature-induced peri

238 The treatment of SCNT embryos with melatonin significantly reduced the level of ROS and H3K

239 Melatonin significantly restricted ligature-induced peri

240 The ability of PolyRad to protect melatonin structure was also carried out using 0, 1, 5 a

241 ly on hibernating animals, demonstrated that melatonin supplementation and a short photoperiod increa

242 Furthermore, melatonin supplementation diminished the Ca.

243 Moreover, melatonin supplementation enhanced the endogenous conten

244 entia, namely timed bright light therapy and melatonin supplementation.

245 Mean melatonin suppression (~40%) and recovery (~50%) were si

246 the previously published action spectra for melatonin suppression [1,2] pointed to a possible role o

247 We studied the dynamics of melatonin suppression and changes in cortisol levels in

248 The functional relationship between melatonin suppression and the light spectrum and amount

249 The magnitude of nocturnal melatonin suppression depends upon the spectrum, amount,

250 functional relationship to predict nocturnal melatonin suppression during the early biological night

251 Melatonin suppression occurred rapidly within the first

252 -level dose-response curves to light-induced melatonin suppression using a within-subjects protocol.

253 Melatonin suppression was determined for each light leve

254 ulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex, and s

255 a role of S cones in the acute alerting and melatonin-supressing response to evening light exposure.

256 The neuromodulator melatonin synchronizes circadian rhythms and related phy

257 the purified recombinant MzASMT9 protein for melatonin synthesis were 500 muM and 12 pmol/min.mg prot

258 tyltransferase (AANAT; the enzyme regulating melatonin synthesis) or inhibition of miR-200b in cholan

259 e is consequently thought to be important in Melatonin synthesis, but limited data and reference text

260 ion of chloroplasts, the terminal enzyme for melatonin synthesis, N-acetylserotonin-O-methyltransfera

261 When N-acetylserotonin, a substrate for melatonin synthesis, was fed to purified chloroplasts, t

262 partially mediated through delayed offset of melatonin synthesis.

263 Novel melatonin-tamoxifen drug conjugates may be promising to

264 These melatonin-tamoxifen drug conjugates show promise as nove

265 cles for the protection of a candidate drug, melatonin that is used as a sleep aid medication in Inte

266 Melatonin therapy or prolonged exposure to complete dark

267 Here we show that melatonin time-dependently acts on its receptors in the

268 essential for the design of highly selective melatonin tool compounds and therapeutic agents.

269 upled serotonin 5-HT(2C) receptors, in which melatonin transactivates phospholipase C (PLC) through 5

270 ponents in both species when compared to non-melatonin treated plants.

271 Melatonin-treated plants had significantly lower SOD and

272 EP and melatonin treatment (EP-MEL), DM and melatonin treatment (DMMEL), and EP-DM-MEL groups.

273 nduced periodontitis (EP), DM, EP-DM, EP and melatonin treatment (EP-MEL), DM and melatonin treatment

274 Melatonin treatment at 100mumol/L triggered H2O2 accumul

275 When plants were subjected to water deficit, melatonin treatment increased the concentration and comp

276 his study, it can be concluded that systemic melatonin treatment may decrease osteoclastic activity a

277 study is to evaluate the effects of systemic melatonin treatment on serum oxidative stress index (OSI

278 pe and Mdr2(-/-) mice exposed to darkness or melatonin treatment or in male patients with PSC and hea

279 Melatonin treatment significantly reduced fasting plasma

280 Mdr2(-/-) mice subjected to dark exposure or melatonin treatment.

281 In particular, melatonin treatments improved the primary oil components

282 usion, reduced irrigation regimes as well as melatonin treatments resulted in a significant improveme

283 We identified that melatonin usage (odds ratio [OR] = 0.72, 95% CI 0.56-0.9

284 Importantly, melatonin usage (OR = 0.48, 95% CI 0.31-0.75) is associa

285 active comparator design, we determined that melatonin usage was associated with a reduced likelihood

286 Drug release and effectiveness of melatonin using PolyRad were evaluated on human umbilica

287 ight intensity at 2 h before sleep and lower melatonin values (01:00 h).

288 Melatonin was added during the preimplantation developme

289 ic and transcriptional response of exogenous melatonin was assessed in two commercial cultivars of sw

290 Melatonin was associated with better sleep quality, whic

291 The evening rise in melatonin was attentuated under both WL and BL only in t

292 Cytotoxicity of melatonin was carried out using both live/dead and MTT a

293 Melatonin was detected in the leaves of Valencia sweet o

294 In addition, melatonin was detected to cause a significant decrease o

295 p (P >0.05); and the therapeutic activity of melatonin was limited (P >0.05).

296 At 5 mol% melatonin, we observed phase separation in samples with

297 essant agomelatine had a similar effect than melatonin when applied alone but blocked the melatonin-p

298 he rhythmic production of the pineal hormone melatonin, which has been implicated in human sleep.

299 patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leadin

300 g siRNA diminished the protective effects of melatonin, while the membrane melatonin receptors (MT1 o