ライフサイエンスコーパス: membrane channel

1 lasmic membrane fusion protein, and an outer membrane channel.

2 f the tetrameric amantadine-blocked M2 trans-membrane channel.

3 9 and Toc34, as well as Toc75, a beta-barrel membrane channel.

4 n reported to be a swelling-activated plasma membrane channel.

5 activation of a specific inner mitochondrial membrane channel.

6 of anions through SLAC, a phospho-activated membrane channel.

7 in protein translocation through the SecYEG membrane channel.

8 ane fusion protein; and a beta-barrel, outer membrane channel.

9 ening and closing of this beta-barrel, outer membrane channel.

10 ning Sec signal sequences through the SecYEG membrane channel.

11 cators, VopB2 and VopD2, that constitute the membrane channel.

12 d is ultimately eliminated through the outer membrane channel.

13 riability in tension sensitivity among these membrane channels.

14 probability of carboxyfluorescein-permeable membrane channels.

15 obvious in studies of ion permeation through membrane channels.

16 etween inner membrane transporters and outer membrane channels.

17 s and it does not occur through recycling of membrane channels.

18 ffusion and does not require facilitation by membrane channels.

19 l transduction from the stores to the plasma membrane channels.

20 of VacA was dependent on its ability to form membrane channels.

21 an either potentiate or inhibit a variety of membrane channels.

22 hat modulate the function of these important membrane channels.

23 hout major effects on other gap junctions or membrane channels.

24 cessary for the formation of anion-selective membrane channels.

25 eric structures and can form anion-selective membrane channels.

26 ed the capacity of each mutant toxin to form membrane channels.

27 movement of water through aquaporin-4 (AQP4) membrane channels.

28 a toxin, VacA, that can form anion-selective membrane channels.

29 ependent on the formation of anion-selective membrane channels.

30 phages also exploit chromosome-encoded outer membrane channels.

31 enhancement of calcium influx through plasma membrane channels.

32 obalt exerted a nonspecific effect on glomus membrane channels.

33 ins which function as regulatory subunits of membrane channels.

34 n increases the number of functional surface membrane channels.

35 e found that these receptors form oligomeric membrane channels.

36 the geometry and functionality of biological membrane channels.

37 key transport characteristics of biological membrane channels.

38 assembly and the incorporation of functional membrane channels.

39 , represent a simplified model of biological membrane channels.

40 binding, molecular machines, and biological membrane channels.

41 oproteins (Panx1, -2, and -3) forming single membrane channels.

42 ucting cells by stably expressing only three membrane channels.

43 ondence of R(h) and R(p), the pore radius of membrane channels: a polymer such as PEG diffuses with i

44 ng ion channels (ASICs) are cation-selective membrane channels activated by H(+) binding upon decreas

45 y (CCE), the influx of Ca(2+) through plasma membrane channels activated in response to depletion of

46 own to inhibit cellular vacuolation and VacA membrane channel activity also inhibit cytochrome c rele

47 hanism dependent on cellular entry and toxin membrane channel activity.

48 roteins and regulates endolysosome-localized membrane channel activity.

49 ins are proteins that can self-assemble into membrane channels (also known as pores).

50 pecific characteristics among the large pore membrane channels; an open (hemi)channel is not a nonsel

51 toplasmic and outer membranes, with an outer membrane channel and a periplasmic adaptor protein, and

52 sional structure for the trimeric CusC outer membrane channel and developed a model of the tripartite

53 the interaction between a voltage-dependent membrane channel and eNOS may be important for regulatin

54 e recent discovery that human SAA1.1 forms a membrane channel and have important implications for und

55 cture is the largest determined for an outer-membrane channel and is unprecedented in being composed

56 of voltage-dependent anion channel (VDAC), a membrane channel and NADH oxidase, as a cause of early m

57 ey periplasmic interaction between the outer membrane channel and the adaptor protein in the assemble

58 s: the inner membrane transporter, the outer membrane channel and the periplasmic lipoprotein.

59 in response to Ca(2+) influx through plasma membrane channels and Ca(2+) release from intracellular

60 ity is limited by the kinetics of the neuron membrane channels and can be stopped by brief inhibitory

61 ~10(8) higher resistance than pores in lipid membrane channels and carbon nanotubes.

62 variables such as the relative abundance of membrane channels and channel kinetic rates.

63 nels has two components: a reduced number of membrane channels and decreased potentiation of the rema

64 nalize the role of hDlg in the clustering of membrane channels and formation of multiprotein complexe

65 form a large and widespread family of outer membrane channels and have been implicated in the uptake

66 ve illuminated how single-atom ions permeate membrane channels and how selectivity among them is achi

67 biology is controlled by stimuli-responsive membrane channels and molecular machine ion pumps such a

68 dherins, cell adhesion molecules, receptors, membrane channels and other transmembrane proteins.

69 a disproportionate percentage of cytoplasmic membrane channels and outer-membrane porins.

70 both the ionic current and fluorescence from membrane channels and pores has the potential to link st

71 es in the synthesis and assembly of designed membrane channels and pores include addressable template

72 s, direct interaction with and modulation of membrane channels and proteins, regulation of gene expre

73 spectrin-actin-based cytoskeleton, integral membrane channels and receptors, and membrane-associated

74 teractions with proteins, in particular with membrane channels and receptors.

75 in opposition to influx through other plasma membrane channels and release from stores.

76 from the extracellular medium through plasma membrane channels and that the second and third elevatio

77 lly, the function of a variety of additional membrane channels and transporters is altered by pH vari

78 In GPCRs, as well as membrane channels and transporters, amino acid residues

79 sets compartment-specific activity codes for membrane channels and transporters.

80 TolC is an outer membrane channel, and AcrA is an elongated lipoprotein t

81 diffuses with its long axis parallel to the membrane channel, and passes through the channel without

82 lipid destabilization, activation of native membrane channels, and aggregation of Abeta into Ca(2+)-

83 ric structures, formation of anion-selective membrane channels, and entry of VacA into host cells.

84 tructure categories, including cytoskeleton, membrane channels, and extracellular region.

85 tant phenomenon in biological and artificial membranes, channels, and nanopores.

86 simulated data of a tetrameric alpha-helical membrane channel (Aquaporin-0) solubilized by n-Dodecyl

87 ysiological studies of presumed TRPML plasma membrane channels are contradictory and inconsistent wit

88 me glutamate receptor subunits of ionotropic membrane channels are edited by site-specific base-deami

89 These membrane channels are heteromeric complexes that compris

90 While the gap junction membrane channels are recognizable in negatively stained

91 ilable data on native STIM2-regulated plasma membrane channels are scarce.

92 Membrane channels are subject to a wide variety of regul

93 mp consists of a soluble ATPase (ArsA) and a membrane channel (ArsB).

94 et electric field falls primarily across the membrane channel, as expected for two conductive baths s

95 t communicate events within the ER to plasma membrane channels, as binding and signaling partners of

96 equence that define solution aggregation and membrane channel assembly.

97 te organisms express proteins specialized in membrane channel-based cell-cell communication that are

98 nd should be useful in the de novo design of membrane channels both for basic studies of ion permeati

99 ton transfer in the SS dimer is probably the membrane-channel/bulk solution interface.

100 roposed to measure the water permeability of membrane channels by means of molecular dynamics simulat

101 nanotubes can provide a simplified model of membrane channels by reproducing these critical features

102 olar water movement is largely controlled by membrane channels called tonoplast-intrinsic aquaporins

103 hat the conductance of a mitochondrial inner membrane channel, called MCC, was specifically blocked b

104 the recent discovery that tension-sensitive membrane channels can catalyze the conversion of the ina

105 Thus, double-membraned channels can be induced by expression of recom

106 Intercellular communication via gap junction membrane channels cannot occur until two apposing hemich

107 1AR) and cAMP (optoB2AR), or Ca(2+)-permeant membrane channels (CatCh2) in smooth muscle (Acta2) and

108 rstanding of key process constraints such as membrane channel clogging, and of the science of membran

109 ComH with a periplasmic domain of the inner-membrane channel ComEC, which is known to mediate the tr

110 Here, we use a biophysical model of the membrane-channel complex to analyze the nature of the ga

111 TolC functions as the outer membrane channel component for both type I secretion and

112 TolC is the outer membrane channel component used by the type I secretion

113 T-DNA substrate is delivered from the inner membrane channel components VirB6 and VirB8 to periplasm

114 visiae triggers Ca2+ influx through a plasma membrane channel composed of Cch1 and Mid1.

115 mbrane and, in some manner, activates plasma membrane channels comprising Orai1, -2, and -3 subunits.

116 -nitrosylation, we tested whether CNs affect membrane channel conductance directly in neurons isolate

117 rm sensors derives from voltage-gated Ca(2+) membrane channels configured such that an increase in te

118 roteins; comparison of transporter and outer membrane channel contents from different organisms; know

119 he inner-membrane efflux pump CusA and outer-membrane channel CusC to mediate resistance to Cu(+) and

120 ty to ubiquitylate ENaC and increases apical membrane channel density by reducing its endocytosis.

121 n during maintained stimulation, and reduced membrane channel density causes hyperexcitability.

122 ingly heterogeneous group of primary cardiac membrane channel diseases.

123 A translocates polypeptides through the SecY membrane channel during protein secretion in bacteria, b

124 ic complexes capable of cross-linking plasma membrane channels (e.g. metabotropic glutamate receptor)

125 e plasma membrane, creating an extracellular membrane channel (EMC) to the outside of the cell.

126 e plasma membrane, creating an extracellular membrane channel (EMC) to the outside of the cell.', and

127 e plasma membrane, creating an extracellular membrane channel (EMC) to the outside of the cell.'.

128 brane fusion protein (MFP) family; and outer membrane channels exemplified by the Escherichia coli To

129 t in a pro-inflammatory state, a decrease in membrane channel expression leading to reduced Slack-med

130 tive in the capacity to form anion-selective membrane channels fail to cause clustering and redistrib

131 ) is a member of the Major Intrinsic Protein membrane channel family.

132 member of the major intrinsic protein (MIP) membrane channel family.

133 nslocation to the cell surface via the outer membrane channel FhaC.

134 -MDa hexameric nanomachine, forming an inner membrane channel for effectors to pass through.

135 bearing deletions of opmH, encoding an outer membrane channel for efflux substrates, and four efflux

136 and Moore indirectly supports the idea of a membrane channel for potassium conductance.

137 surface, suggesting that EsxEF form an outer membrane channel for toxin export.

138 Glucose transporters form specialized membrane channels for the transport of sugars into and o

139 Many plasma membrane channels form oligomeric assemblies, and hetero

140 whether these GXXXG motifs are required for membrane channel formation and cytotoxicity and to clari

141 The p33 domain is required for membrane channel formation and intracellular toxic activ

142 s, whereas mutant VacA proteins defective in membrane channel formation do not.

143 and cytotoxicity and to clarify the role of membrane channel formation in the biological activity of

144 , and they also provide strong evidence that membrane channel formation is essential for VacA cytotox

145 hydrophobic region of VacA are essential for membrane channel formation, and they also provide strong

146 semble into oligomeric structures capable of membrane channel formation.

147 e for the p33 domain, which is essential for membrane channel formation.

148 brane proteins require ribosome binding to a membrane channel formed by the Sec61p complex.

149 However, membrane channels formed by type s1 VacA and type s2 Vac

150 action of the cytoplasmic SecA ATPase with a membrane channel, formed by the heterotrimeric SecY comp

151 These peptides exhibit antibiotic and membrane channel-forming activities.

152 d G14A) that ablate vacuolating activity and membrane channel-forming activity render VacA unable to

153 abolites is believed to be based in an outer membrane, channel-forming protein known as VDAC (voltage

154 o change the electrical characteristics of a membrane channel from linear to rectifying.

155 uded are those involved in chemotaxis, outer membrane channel function, degradation of aromatic ring

156 sed by deletion of the multifunctional outer membrane channel gene tolC.

157 Pannexin 1 (Panx1) is a plasma membrane channel glycoprotein that plays a role in innat

158 er-selective pathway through the aquaporin-1 membrane channel has been visualized by fitting an atomi

159 This stabilized membrane channel has little evolutionary precedent.

160 ositol trisphosphate, cellular ion pumps and membrane channels has become more clearly understood, in

161 xin 1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in infla

162 According to the membrane channel hypothesis of carotid body O2 chemorece

163 essing cells showed many cell surface double-membraned channels, immunogold SR-BI, apolipoprotein (HD

164 Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological an

165 We conclude that AQP9 serves as membrane channel in hepatocytes for glycerol and urea at

166 results show that PC2 functions as a plasma membrane channel in renal epithelia and suggest that PC2

167 CP55,940, reach the binding pocket through a membrane channel in TM1-TM7.

168 Type s1/m1 VacA from strain 60190 formed membrane channels in a planar lipid bilayer assay at a s

169 Nanopores also function as membrane channels in all living systems, where they serv

170 Plasma membrane channels in embryonic cones have a high turnove

171 It forms ionic membrane channels in fungal cells.

172 cytoplasmic membrane transporters and outer membrane channels in organisms whose complete genome seq

173 Certain membrane channels including acetylcholine receptors, gap

174 Pannexin-1 (Panx1) is a large-pore membrane channel involved in the release of ATP and othe

175 reticulum, although Ca(2+) influx via plasma membrane channels is also necessary to sustain the oscil

176 The flow of ions through membrane channels is precisely regulated by gates.

177 TolC, which forms an outer membrane channel, is an essential component of several e

178 iple factors, including K conductance across membrane channels, K driving force as reflected by the t

179 drive many cellular processes, ranging from membrane channel kinetics to transcriptional regulation,

180 All mitochondrial outer membrane channels known to date are beta-barrel membrane

181 med by VacA6-27, a mutant that fails to form membrane channels, lack an organized p33 central core.

182 growth factors increase the number of plasma membrane channels may involve stabilizing them in the pl

183 atives that are excluded from other types of membrane channels may provide molecules with connexin-sp

184 ellular Ca2+ release channels, T-type plasma membrane channels may regulate cell growth.

185 Gap junction membrane channels mediate electrical and metabolic coupl

186 Biological membrane channels mediate information exchange between c

187 ively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find

188 the Mla pathway, which consists of the outer membrane channel MlaA, the periplasmic lipid carrier Mla

189 To remove these toxic ions, the CusC outer membrane channel must form a beta-barrel structural doma

190 -stimulated ENaC open probability and apical membrane channel number.

191 VopQ forms a nonspecific, voltage-gated membrane channel of 18 A resulting in neutralization of

192 e in chloroplast biogenesis in plants as the membrane channel of the protein import translocon at the

193 set of membrane transport systems and outer membrane channels of each organism are annotated based o

194 Substrate-specific outer membrane channels of gram-negative bacteria mediate upta

195 the structure-function relationship of outer-membrane channels of Gram-negative pathogens, mainly foc

196 ssion properties, LTD, and calcium-activated membrane channels of hippocampal CA1 pyramidal neurons i

197 in the brain, and can have rapid actions on membrane channels of neurons.

198 s, most notably diverse TonB-dependent outer membrane channels of unknown substrate specificity.

199 ied the effect of the Escherichia coli outer membrane channel OmpF on the accumulation of the fluoroq

200 The question of how mechanically gated membrane channels open and close is notoriously difficul

201 iption of this "Ca2+ store release to plasma membrane channel opening" link, but to our knowledge the

202 s involves functional homomeric TRPM6 plasma membrane channels or heteromeric channel assemblies with

203 lycosylation may play a role in the neuronal membrane channels or networks involved in the physiology

204 nd to the cytoplasmic domains of a number of membrane channels or receptors.

205 s but on SNAP-25, probably via exocytosis of membrane channels or regulatory molecules.

206 e expression, impair formation of functional membrane channels, or alter channel conductance.

207 Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of fin

208 mary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play

209 Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules

210 ersible linkage to SUMO silences K2P1 plasma membrane channels; phosphorylation of K2P3 enables 14-3-

211 orce microscopy (AFM) images 3D structure of membrane channels placed on a solid substrate.

212 , carbon nanotubes (CNTs) should be an ideal membrane channel platform: they exhibit excellent transp

213 Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in many Ca(2+) signa

214 nd regulated by HpUreI, a proton-gated inner membrane channel protein essential for gastric survival

215 d to study selectivity and regulation of the membrane channel protein GlpF and the enzyme glycerol ki

216 g 24 h exposure to chronic hypoxia (CH), and membrane channel protein levels were enhanced.

217 tuberculosis (Mtb) mutant lacking the outer membrane channel protein Rv1698 accumulated 100-fold mor

218 nts, an inner membrane transporter, an outer membrane channel protein, and a periplasmic protein, whi

219 Here, we show that a membrane channel protein, chloride intracellular channel

220 ands have been identified that link titin to membrane channels, protein turnover and gene expression.

221 Membrane channel proteins are of great interest as pulse

222 glutamate receptors (GluRs) are ligand-gated membrane channel proteins found in the central neural sy

223 of a 191-base pair fragment associated with membrane channel proteins M1 and M2 of the influenza-A v

224 Membrane channel proteins of the aquaporin family are hi

225 A large family of membrane channel proteins selective for transport of wat

226 We identified GTPases, membrane channel proteins, and microtubule associated ta

227 d function of Aquaporins (AQPs), a family of membrane channel proteins, involved in several body func

228 Aquaporins (AQP) are water-specific membrane channel proteins.

229 ch tools against known transporter and outer membrane channel proteins; comparison of transporter and

230 ng), HlyD (membrane fusion), and TolC (outer membrane channel) proteins were identified.

231 Consistent with a mechanism of plasma membrane channel-PSD-95 binding, coexpression with PSD-9

232 stand the functional role of the peroxisomal membrane channel Pxmp2, mice with a targeted disruption

233 keleton controls the disposition of selected membrane channels, receptors, and transporters.

234 in either ACC2 or Tic20-IV, the chloroplast membrane channel required for ACC2 uptake.

235 re essential components of the putative VirB membrane channel required for transfer of the T-complex

236 predicted to be structurally similar to VacA membrane channels) reveals that p55 and the beta-helical

237 omprising at its core an ATPase, SecA, and a membrane channel, SecYEG, is responsible for the majorit

238 Ligand-gated membrane channels selectively facilitate the entry of ir

239 Because the chemical composition of the membrane-channel/solution interface is strikingly differ

240 ting step being in the channel and/or at the membrane-channel/solution interface, and not in bulk sol

241 f close contacts of the substrate with inner membrane channel subunits but blocked formation of conta

242 he molecular dynamics simulation of a simple membrane-channel system.

243 ynamics on anesthetic action in a simplified membrane-channel system.

244 h guanidinium groups, leading to a transient membrane channel that facilitates the transport of argin

245 The PTP is an inner membrane channel that forms from F-ATPase, possessing a

246 lasmic reticulum, Orai1 (CRACM1) as a plasma membrane channel that is activated by the store-operated

247 electrocyte junction are best described by a membrane channel that meters transmitter from a presynap

248 xin hemichannels are Ca(2+)-permeable plasma membrane channels that are also controlled by [Ca(2+)](i

249 such as ion pumps, transporters, and plasma membrane channels that control guard cell turgor pressur

250 or intrinsic proteins (MIPs) are a family of membrane channels that facilitate the bidirectional tran

251 Aquaporins are membrane channels that facilitate the flow of water acro

252 p (transient receptor potential) form plasma membrane channels that mediate Ca(2+) entry following th

253 ian homologues of Drosophila Trp form plasma membrane channels that mediate Ca(2+) influx in response

254 Gap junctions are membrane channels that mediate electrical and metabolic

255 in 1 (PANX1) subunits form oligomeric plasma membrane channels that mediate nucleotide release for pu

256 tionally interacts with and activates plasma membrane channels that mediate store-operated Ca(2+) ent

257 ansporters) form a superfamily of pentameric membrane channels that translocate monovalent anions acr

258 ion through macromolecular associations with membrane channels that transport chloride, bicarbonate,

259 evidence that GldL and GldM assemble dynamic membrane channels that use the proton gradient to power

260 ry nerves, in particular their receptors and membrane channels; the plasticity of the pathways; and t

261 For membrane channels, this effect can alter the critical me

262 o the opening of another outer mitochondrial membrane channel through which cytochrome c can transit,

263 model for perforin (acting by forming a cell membrane channel through which granzymes pass) does not

264 ) and, therefore, should not be able to form membrane channels, thus eliminating this possible mechan

265 tes entry of external calcium through plasma membrane channels to affect immune cell activation.

266 is of the contribution of ion fluxes through membrane channels to changes of intracellular ion concen

267 ns at the outer membrane and includes a core membrane channel, Toc75, and two receptor proteins, Toc3

268 The outer membrane channel TolC is a key component of multidrug ef

269 he inner membrane transporter AcrB and outer membrane channel TolC is thought to be mediated by AcrA.

270 asmic membrane fusion protein, and the outer membrane channel TolC(HI).

271 This pump assembly comprises the outer-membrane channel TolC, the secondary transporter AcrB lo

272 cts were obtained in cells lacking the outer membrane channel TolC, which acts with AcrEF, suggesting

273 er AcrB of the RND superfamily and the outer membrane channel TolC.

274 in vivo function of MacAB requires the outer membrane channel TolC.

275 rter and establishes the link with the outer membrane channel TolC.

276 lar calcium to enter the cell through plasma membrane channels, too.

277 IcsA requires the SecA ATPase and the SecYEG membrane channel (translocon) for secretion.

278 y slaves to the levels of Ca2+ determined by membrane channels, transporters and exchangers, but are

279 f the transient receptor potential family of membrane channels (TRPC) have been implicated in the gen

280 DPR controls cation entry through the plasma membrane channel TRPM2.

281 t Bcl-x(L) maintains the outer mitochondrial membrane channel, VDAC, in an open configuration.

282 dulated by the outer and inner mitochondrial membrane channels, voltage-dependent anion channel 1 and

283 lls when synaptic transmission and intrinsic membrane channels were inoperative.

284 Uncouplers and blockers of membrane channels were used to investigate the mechanism

285 for stabilizing interactions with the outer membrane channel, whereas TriB is important for the stim

286 re defective in formation of anion-selective membrane channels, whereas proteins containing G121R or

287 A, and G26A mutations formed anion-selective membrane channels, whereas VacA proteins containing P9A,

288 nifest the transient opening of nonselective membrane channels, which admits fluorescent indicators o

289 ing properties of bacterial mechanosensitive membrane channels, which are thought to confer osmoprote

290 These plasma membrane channels, which connect the cytoplasm of adjace

291 data demonstrate that Unx1 forms large-pore membrane channels, which may serve as a diffusional path

292 ermediate, the outer and inner mitochondrial membrane channels, which normally interact only transien

293 s of unplugging and then replugging the C-Eb membrane channel, while nutrient detection during germin

294 f the permeability transition pore, an inner membrane channel whose opening requires matrix Ca(2+) an

295 gap junctional channels, Panx1 forms single-membrane channels, whose functional role in neuronal cir

296 his structure identifies VirB10 as the outer-membrane channel with a unique hydrophobic double-helica

297 developing synthetic analogues of biological membrane channels with high efficiency and exquisite sel

298 f wild-type VacA and VacA-(Delta6-27) formed membrane channels with properties intermediate between t

299 nitude greater than any previously described membrane channel, with an average diameter of 340 nm and

300 t to subsequently be transported through the membrane channel without the interference of cytosolic b