ライフサイエンスコーパス: membrane domain

1 s are triggered within its 200 angstrom wide membrane domain.

2 2, an LYR protein, to the matrix face of the membrane domain.

3 an unspecified way with the a-subunit in the membrane domain.

4 termembrane space and probably stabilize the membrane domain.

5 and a SUMO3 covalent SUMOylation site in the membrane domain.

6 rom the protein surface to the center of the membrane domain.

7 and maintaining this unique neuronal plasma membrane domain.

8 d ionizable residues along the center of the membrane domain.

9 very of this transporter to the outer plasma membrane domain.

10 uter membrane protein-like beta-barrel trans-membrane domain.

11 nge of equivalent sites on the c ring of the membrane domain.

12 complex I/NDH-1) contains a peripheral and a membrane domain.

13 created by solubilization of a common FC/PL membrane domain.

14 restricting F-actin formation to the correct membrane domain.

15 general stress-sensing and stress-protective membrane domain.

16 ry-related locations in four subunits of the membrane domain.

17 CBS domain and Pro-sigma(K) cleavage by the membrane domain.

18 s correct nuclear placement toward the inner membrane domain.

19 odynamically drive proton pumping across its membrane domain.

20 translocation of ICAM-1 into caveolin-1-rich membrane domains.

21 2 interacts with HER2 in specific actin-rich membrane domains.

22 es on identification and characterization of membrane domains.

23 translocation of ICAM-1 into caveolin-1-rich membrane domains.

24 CBS domain conformational changes to channel membrane domains.

25 or the repartitioning of proteins within the membrane domains.

26 zation and clustering of K-Ras4B in distinct membrane domains.

27 receptor co-localization in cholesterol-rich membrane domains.

28 lymers that change the curvature of cellular membrane domains.

29 role in the dynamic assembly of specialized membrane domains.

30 lulose synthase complexes (CSCs) into narrow membrane domains.

31 ely homologous membrane proteins in distinct membrane domains.

32 n be distributed in rigid and loosely packed membrane domains.

33 elination nor the establishment of polarized membrane domains.

34 dule that targets them to specific endocytic membrane domains.

35 ts receptor enrichment through Caveolin-rich membrane domains.

36 pendent reorganization of PI(4,5)P2-enriched membrane domains.

37 ly enriched at apical and basal polar plasma membrane domains.

38 me have been seriously misinterpreted in the membrane domains.

39 expansion and contraction of specific plasma membrane domains.

40 ally or direct assembly to tetherin-negative membrane domains.

41 the bone-facing ruffled membrane from other membrane domains.

42 tein distribution and retention in different membrane domains.

43 ) did not fractionate in detergent-resistant membrane domains.

44 egulate the function and dynamics of ordered membrane domains.

45 Rabaptin5 was necessary to pattern Rab5 into membrane domains.

46 endent phosphatidylserine-binding peripheral membrane domains.

47 nal changes to the extracellular side of the membrane domains.

48 c peptide at the N terminus and no predicted membrane domains.

49 n of signaling platforms in cholesterol-rich membrane domains.

50 rds (apical) (rather than rootwards (basal)) membrane domains.

51 compositions resembling pre-existing plasma-membrane domains.

52 s, which form specialized and highly-ordered membrane domains.

53 roteins such as GPCRs partition into ordered membrane domains.

54 cking of PCP components to compartmentalized membrane domains.

55 en shown to colocalize with cholesterol-rich membrane domains.

56 ith cholesterol and sphingomyelin in ordered membrane domains.

57 to co-exist with saturated lipids in ordered membrane domains.

58 mponents that segregate into nanometer-scale membrane domains.

59 The addition of actin filaments reorganized membrane domains.

60 lipid packing of both ordered and disordered membrane domains.

61 borders between appressed and non-appressed membrane domains.

62 e formation of phase-separated intracellular membrane domains.

63 dent, HA and NA occupy distinct but adjacent membrane domains.

64 d two distinct and mutually exclusive plasma membrane domains.

65 le existence and significance of specialized membrane domains.

66 tes the formation of, and stabilizes ordered membrane domains.

67 eening approach identified residues on trans-membrane domains 1alpha, 5, and 7 on one face of B(0)AT3

68 tified a single hydrophobic residue in trans-membrane domain 7 of class II glucose transporters as a

69 polyunsaturated fats on the organization of membrane domains across a spectrum of membrane models, i

70 euron-glia interactions establish functional membrane domains along myelinated axons.

71 s in increased activated integrin in buoyant membrane domains along with increased association betwee

72 During catalysis, the MalFG membrane domain alternates between inward and outward fa

73 protein consisting of an N-terminal integral membrane domain and a C-terminal extracytoplasmic domain

74 reveals a previously uncharacterized helical membrane domain and a periplasmic facing soluble domain.

75 ructure of these linkers, extending from the membrane domain and including the CaVbeta-binding site,

76 wed by the extracellular domain, most of the membrane domain and the gate.

77 e CD40 relocation to the detergent-resistant membrane domain and to inhibit CD40-induced phosphorylat

78 a C-terminal hydrophobic, potentially trans-membrane domain and were described as type I transmembra

79 in Are2p relocalization to detergent-soluble membrane domains and a significant decrease (53-36%) in

80 s in the basal state are already confined in membrane domains and are associated with clathrin.

81 We characterized these membrane domains and determined their lateral dynamics b

82 proteins composed of multiple alpha-helical membrane domains and large cytoplasmic C-termini contain

83 ossible to generate hierarchically-organized membrane domains and microscale 2-D array patterns of do

84 f proteins that are important for organizing membrane domains and receptor signaling and regulating t

85 Membrane domains and the underlying actin cytoskeleton c

86 ls and cell adhesion molecules within plasma membrane domains and thereby promote physiological activ

87 we demonstrated that FPs constitute distinct membrane "domains" and that their characteristic 10-nm p

88 d biosynthesis) and StoA (apical sterol-rich membrane domains), and its essentiality in polar deposit

89 and dynamics of the cytoplasmic domain, the membrane domain, and the connecting linker in a complete

90 flecting distinct structural motifs in their membrane domains, and distinct metabolisms of the host o

91 e in apical membrane at the expense of other membrane domains, and that both proteins can do this ind

92 yoelectron tomography shows that the induced membrane domains are equivalent in size and caveolin den

93 iverge at bud emergence when distinct plasma-membrane domains are formed and separated by a septin ri

94 separation may explain why micrometer-scale membrane domains are observed in isolated, cytoskeleton-

95 The link continues over the entire membrane domain as a flexible central axis of charged an

96 ed to move through cellular compartments and membrane domains as intact groups of protomers.

97 calised in association with milk fat globule membrane domains as they contain both hydrophobic and hy

98 sing and others confined in 100-600-nm-sized membrane domains as well as immobile receptors.

99 ture of HSPCs resulted in disruption of this membrane domain, as evidenced by disruption of polarity

100 e of LAMP1(+) lysosomes, with some lysosomal membrane domains associated with endosomes.

101 on, indicating efficient sorting into plasma membrane domains associated with T cell activation; this

102 dies and interact, via their plus ends, with membrane domains associated with the PCP proteins Frizzl

103 uited from endothelial filopodia to discrete membrane domains at cell-cell contacts.

104 roscopy in live cells, we identify PIP2-rich membrane domains at sites of vesicle fusion.

105 d localization and its relationship with the membrane domains at which it assembles.

106 ate transient states in the specification of membrane domains before differentiation into ForB decora

107 ed signal, as it is restricted to the plasma membrane domain between recently divided cells during th

108 lycosylation sites, signal peptides or trans-membrane domains between African and Brazilian strains.

109 The bacterial F1 domain is attached to the membrane domain by peripheral and central stalks.

110 membrane and supports the stability of this membrane domain by repressing the Crumbs-containing apic

111 Disruption of cholesterol-rich membrane domains by filipin inhibits Plvap Ab/SOD endocy

112 ynaptic vesicles (SVs) fuse at a specialized membrane domain called the active zone (AZ), covered by

113 Cholesterol-enriched membrane domains called lipid rafts influence the functi

114 Although some features of membrane domains can be probed by indirect methods, thes

115 endence of this PM domain to investigate how membrane domains can independently integrate a signal th

116 Our results demonstrate that distinct membrane domains can integrate a common signal with spec

117 clear, with possible roles in COPII binding, membrane domain chaperoning, and lipid organization.

118 oyls and farnesyl for ordered and disordered membrane domains, clustered tH molecules segregate to th

119 CSs) function to facilitate the formation of membrane domains composed of specialized lipids, protein

120 Eisosomes are plasma membrane domains concentrating lipids, transporters, and

121 form the conducting pore using four repeated membrane domains connected by intracellular linkers.

122 and a hydrophobic ring of c-subunits in the membrane domain constitute the enzyme's rotor.

123 The membrane domain contains six additional subunits named A

124 The TRPV1 S1-S4 membrane domain couples chemical ligand binding to the p

125 The membrane domain crystallized as a symmetric dimer, with

126 s into molecularly and functionally distinct membrane domains depends on axoglial junctions that func

127 tivation induces helix movement in the HtrII membrane domain diagnostic of transducer activation.

128 olesterol into transient detergent-resistant membrane domains (DRMs) within the ER, also called the E

129 erse directions across the 200 angstrom long membrane domain during enzyme turnover, without signific

130 ms for channel localization, and may feature membrane domains each with distinct roles in excitation.

131 served protein loops linking cytoplasmic and membrane domains enable scalable energy conversion in al

132 ct with osteoblasts in vitro via a polarized membrane domain enriched in adhesion molecules such as t

133 An apical plasma membrane domain enriched in the regulatory phospholipid

134 ab22aQ64L mutant caused fragmentation of TGN membrane domains enriched for ATP7A.

135 ment, lipid rafts, which are phase-separated membrane domains enriched in cholesterol and saturated l

136 for the two lipids, whereas the presence of membrane domains enriched in one of the two lipids shoul

137 clustering in neurons and are important for membrane domain establishment and maintenance in many ce

138 Co-existing disordered and ordered (raft) membrane domains exist in Borrelia burgdorferi, the caus

139 ants, the epidermis, and its outer (lateral) membrane domain facing the environment are continuously

140 ne (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria a

141 e as a functional protein key for organizing membrane domains for cellular signalling.

142 ar the nucleotide-binding domains and in the membrane domains, for transporter embedded in a biologic

143 uoles, Ltc1 was required for sterol-enriched membrane domain formation in response to stress.

144 oke for the conformational switch of the two membrane domains from the inward-facing conformation to

145 on ubiquitously modulates Ca homeostasis and membrane domain function in cells that express NCX prote

146 ne domains (rafts) is a key to understanding membrane domain function, it is important to define the

147 The WLS membrane domain has close structural homology to G prote

148 The segregation of lipids into lateral membrane domains has been extensively studied.

149 , two transmembrane helices (3 and 4) in the membrane domains have their cytoplasmic extensions in cl

150 ing sites and alphaM2-alphaM3 linkers in the membrane domain--have the highest varphi-values (change

151 d that IRK-GFP localizes to the outer plasma membrane domain in endodermal cells but localizes to dif

152 assemble asymmetrically at polarized plasma membrane domains in a co-dependent and AP-1-dependent ma

153 ese results provide evidence for the role of membrane domains in BCR signaling and a plausible mechan

154 The existence of nanometer scale membrane domains in binary lipid mixtures has been shown

155 sion depletes uPAR from distinct basolateral membrane domains in breast cancer cells, resulting in a

156 g the importance of these specialized plasma membrane domains in cellular feedback via the Hippo path

157 aling and highlight the importance of non-AJ membrane domains in dictating cell shape in tissue morph

158 asolateral determinants specify and maintain membrane domains in epithelia.

159 gregation of distinct and mutually exclusive membrane domains in epithelial cells.

160 is, but whether vesicles fuse into PIP2-rich membrane domains in live cells and whether PIP2 is metab

161 calated disc, NaV1.5 is present in different membrane domains in myocytes and interacts with several

162 such as the lipids, in defining specialized membrane domains in PD remains unknown.

163 evidence for the involvement of specialized membrane domains in signal transduction.

164 us, our data identify the unique role of the membrane domains in the regulation of the number of surf

165 homogenate, plasma membrane, and lipid-raft membrane domains in tissue from normal control subjects,

166 technique, to measure the size of nanoscopic membrane domains in unilamellar vesicles with unpreceden

167 direct and quantitative imaging of submicron membrane domains in vitrified, hydrated vesicles.

168 nd they variously associate with specialized membrane domains, in a polarized fashion, to intercellul

169 ) coordinates protein composition of diverse membrane domains, including epithelial lateral membranes

170 e number of AChR clusters associated with Ld membrane domains increased concomitantly.

171 To identify possible membrane domains, individual hydrophobic domains from VP

172 om ER exit sites onto liquid-ordered vacuole membrane domains, initiating micro-lipophagy.

173 athway triggered by ribosome collisions when membrane domain insertion and/or folding fails.

174 ich in PI(4,5)P2 and inward budding of these membrane domains into the lumen of GUVs.

175 Caveolae are invaginated plasma membrane domains involved in mechanosensing, signaling,

176 alization of signaling receptors to distinct membrane domains is a potential source of signaling outp

177 ts reveal that vesicle fusion into PIP2-rich membrane domains is facilitated by sequential PIP2-depen

178 correct ratio of apical, basal, and lateral membrane domains is important for epithelial physiology.

179 ells specify morphologically distinct plasma membrane domains is poorly understood.

180 -dependent translocation to PIP2-rich plasma membrane domains is required for its activity.

181 1 (Cav-1), an integral component of caveolar membrane domains, is expressed in several retinal cell t

182 eover, precise EXO84b placement at the outer membrane domain itself requires ACT7 function.

183 Human AE1 consists of a cytoplasmic and a membrane domain joined by a 33-residue flexible linker.

184 We observed nanometer-scale plasma membrane domains, known as protein islands, on naive T c

185 The membrane domain MalFG may be naturally stable in the inw

186 ed the tricellular vertices as a specialized membrane domain marked by the integral membrane protein

187 The data support the notion that 6TM AC membrane domains may operate as receptors which directly

188 otic spindle midzone, here named the midzone membrane domain (MMD), is essential for spindle disassem

189 e-acting factor involved in keeping specific membrane domains next to the callose wall to prevent for

190 Three antiporter-like subunits in the membrane domain, NuoL, NuoM, and NuoN (ND5, ND4 and ND2,

191 In addition, the membrane domain of AE1 (mdAE1) efficiently mediated anio

192 Overexpression of the membrane domain of Arabidopsis (Arabidopsis thaliana) HM

193 of subcomplex Ibeta, a large portion of the membrane domain of B. taurus complex I that contains two

194 hat does not require covalent binding to the membrane domain of ClC-7.

195 ules control the protonation dynamics in the membrane domain of complex I and establish evolutionary

196 dium ions instead, and three subunits in the membrane domain of complex I are closely related to subu

197 mistic molecular dynamics simulations of the membrane domain of complex I from Escherichia coli.

198 transgenic mice expressing in the liver the membrane domain of HMGCR (HMGCR (TM1-8)), a region neces

199 Our results show that the membrane domain of HMGR contributes to ER morphogenesis

200 The membrane domain of NHE1 is sufficient for ion exchange.

201 culum lumen side of the fifth putative trans-membrane domain of NS4B and the mutation may render the

202 We show that the membrane domain of plant HMGR suffices to trigger ER pro

203 porter protein to be expressed at the apical membrane domain of polarized epithelia.

204 t the cytoplasmic site adjacent to the trans-membrane domain of PRLR-L was responsible for inhibitory

205 the Proregion of Pro-sigma(K) loops into the membrane domain of SpoIVFB, and the rest of Pro-sigma(K)

206 e supernumerary subunits e, f, and g and the membrane domain of subunit A6L are bound.

207 ristic properties of the PTP; therefore, the membrane domain of subunit b does not contribute to the

208 HAP1-Deltab and HAP1-DeltaOSCP, lacking the membrane domain of subunit b or the OSCP, respectively,

209 otein (OSCP) to the catalytic domain and the membrane domain of subunit b to subunit a.

210 The membrane domain of the enzyme extends approximately 180

211 e enzyme's catalytic domain and crossing the membrane domain of the enzyme via two alpha-helices.

212 h the ring of c-subunits that constitute the membrane domain of the enzyme's rotor.

213 cipation in proton translocation through the membrane domain of the enzyme.

214 r turns counterclockwise (as viewed from the membrane domain of the intact enzyme) in 120 degrees ste

215 cted MAS NMR to describe the dynamics of the membrane domain of the Outer membrane protein A of Klebs

216 stitution (G4946E), located within the trans-membrane domain of the RyR, though the exact role of thi

217 MA8 and propose a copper pathway through the membrane domain of these transporters.

218 A sequence based clustering of membrane domains of class III ACs and quorum-sensing rec

219 discussed in the context of partitioning to membrane domains of different lipid composition.

220 It also describes wedge structures in the membrane domains of each monomer, where the skeleton of

221 e comprehensive mutational landscapes in the membrane domains of Glycophorin A and the ErbB2 oncogene

222 and profoundly modified the organization of membrane domains of the alpha-subunit.

223 ge is provided by three alpha-helices in the membrane domains of the b-subunit to which the supernume

224 Membrane domains of the chloroplast envelope are located

225 Here, by directly imaging micron-scale membrane domains of yeast vacuoles both in vivo and cell

226 xistence, nature, and role of highly ordered membrane domains, often referred to as lipid rafts, have

227 ust activate aPKC within a spatially defined membrane domain on one side of the cell in response to s

228 Both consist of a membrane domain on which sits a globular periplasmic dom

229 revealed the coexistence of highly distinct membrane domains on individual cell surfaces.

230 ctional expression of AE1, the cytosolic and membrane domains operate independently.

231 The linker plus either the N-terminal membrane domain or the C-terminal cystathione-beta-synth

232 +) probes targeted to the cytosol, subplasma membrane domain, or the mitochondrial matrix.

233 clear position at the inner epidermal plasma membrane domain oriented to the cortical cells during ce

234 of a unique trypsin cleavage site within the membrane domain (out of 16 potential Lys and Arg sites).

235 uired for tethering cortical F-actin to cell membrane domains outside the adherens junctions (AJs).

236 SM) that are known to assemble into specific membrane domains play a role in the organization and fun

237 embrane composition has implications for how membrane domain properties may be regulated in vivo.

238 ens in a manner dependent on Casparian strip membrane domain protein (CASP)-like proteins (CASPLs).

239 CASPARIAN STRIP MEMBRANE DOMAIN PROTEINS (CASPs) are four-membrane-span

240 trafficking and the polar placement of outer membrane domain proteins require further exploration.

241 Therefore, the epidermis and the outer membrane domain provide important selective and protecti

242 localization, or nonlocalization, in ordered membrane domains (rafts) is a key to understanding membr

243 embrane inhomogeneities, e.g., the so-called membrane domains, rafts, stalks, etc., lead to different

244 on the full length KpOmpA as well as on its membrane domain, reconstituted in liposomes or in deterg

245 In cells, membrane domains regulate membrane dynamics and biochemi

246 e mechanisms underlying recruitment to these membrane domains remain incompletely understood.

247 y transduction proteins to these specialized membrane domains remain poorly understood.

248 I3Kgamma and further define the Rab-mediated membrane domains required for signaling.

249 Redox-coupled proton translocation in the membrane domain requires long-range energy transfer thro

250 Biophysical understanding of membrane domains requires accurate knowledge of their st

251 e the separation and identification of lipid membrane domain residents, or the characterization of ch

252 x sphingolipids, but also as an organizer of membrane domains segregating receptors and signalosomes.

253 in the axon initial segment are confined to membrane domains separated by periodically spaced actin

254 However, whether protein concentration and membrane domain stability affect Ras clustering in a rev

255 Caveolae are protein-dense plasma membrane domains structurally composed of caveolin-1 or

256 3beta3-domain, peripheral stalk, and, in the membrane domain, subunit a and associated supernumerary

257 tion has shown the importance of specialized membrane domains, such as lipid rafts, protein-lipid com

258 rate that nucleocytoplasmic transport at the membrane domain surrounding the mitotic spindle midzone,

259 mic microclusters (MCs) within a specialized membrane domain termed the immunological synapse (IS).

260 Much evidence suggests that membrane domains, termed lipid rafts, which are enriched

261 protein interactions and a carboxyl-terminal membrane domain that carries out the transport function.

262 ssociation of the anionic Asp-139 toward the membrane domain that couples to conformational changes i

263 fferent type of sphingolipid-enriched plasma membrane domain that depends upon cortical actin.

264 sting because they represent a novel type of membrane domain that is important for plasma membrane or

265 Thus, MLRs provide an active membrane domain that tethers and reorganizes the cytoske

266 s PMP22 is localized to cholesterol-enriched membrane domains that are closely linked with the underl

267 ns also organize the highly localized plasma membrane domains that are important in STIM1-ORAI1 signa

268 s are cholesterol- and sphingolipid-enriched membrane domains that are thought to form transient sign

269 Gap junctions (GJs) represent connexin-rich membrane domains that connect interiors of adjoining cel

270 The clusters induce the formation of ordered membrane domains that exclude the dye 1,1'-dioctadecyl-3

271 barrier to the stability of phase-separated membrane domains that increases in significance as the m

272 of a signaling and transport complex within membrane domains that is necessary for phosphorylation a

273 and plasma membrane, respectively, to create membrane domains that partition upstream regulators of t

274 ding site being located partially within the membrane domain, the possibility has to be considered th

275 tons across its complete approximately 200-A membrane domain, thermodynamically driving synthesis of

276 ant ankB localizes to periodic axonal plasma membrane domains through L1 cell-adhesion molecule prote

277 st-binding domains to the pore-forming trans-membrane domain (TMD), and validated these, to our knowl

278 iate state until MalK binds and converts the membrane domain to the inward-facing state.

279 asymmetrically segregate their apical plasma membrane domain to the nascent daughter cells.

280 cells might integrate signals from different membrane domains to assess their relative position withi

281 PM receptors can be dynamically sorted into membrane domains to underpin signaling in response to ex

282 At these epidermal plasma membrane domains, TWD1 colocalizes with nonpolar ABCB1.

283 Moreover, monovalent CTxB does not stabilize membrane domains, unlike wild-type CTxB.

284 , wild-type GrlA associates with cardiolipin membrane domains via a patch of basic C-terminal residue

285 ional changes that are transduced to channel membrane domains via the H-I loop.

286 Nanoclustering of K-Ras, related to nonraft membrane domains, was enhanced in intact plasma membrane

287 vity is accompanied by formation of distinct membrane domains which differ in local membrane fluidity

288 CASPs show high stability in their membrane domain, which presents all the hallmarks of a m

289 GLDH is attached to a membrane domain, which represents a major fragment of th

290 most CASPLs were able to integrate the CASP membrane domain, which suggests that CASPLs share with C

291 this time, this neuron acquires specialized membrane domains while undergoing extensive polarity rem

292 be useful for understanding other biological membrane domains whose distributions display gradients i

293 d of an endoplasmic reticulum (ER)-anchoring membrane domain with low sequence similarity among eukar

294 By directly monitoring cholesterol-rich membrane domains with a fluorescently tagged cholesterol

295 n and removal of Rabs to create time-limited membrane domains with a unique composition, and can expl

296 ble for the establishment and maintenance of membrane domains with different composition.

297 l cells and neurons exhibit different plasma membrane domains with distinct protein compositions.

298 precise opposite localisations define plasma membrane domains with specific functions.

299 Membrane domains within stereocilia thus define regions

300 Hence, the V-ATPase membrane domain would allow the exocytotic machinery to