ライフサイエンスコーパス: membrane fluidity

1 rsus saturated fatty acyl chains, determines membrane fluidity.

2 The net effect is to reduce membrane fluidity.

3 tributes to a sigma(W)-dependent decrease in membrane fluidity.

4 ent with known effects of LPS composition on membrane fluidity.

5 amic properties, indicating a high degree of membrane fluidity.

6 bilayer samples and make measurements of the membrane fluidity.

7 brane accounts for the effects of calcium on membrane fluidity.

8 phospholipids and contribute to maintaining membrane fluidity.

9 erve to mitigate the effect of aS binding on membrane fluidity.

10 ther than producing the proposed increase in membrane fluidity.

11 nverting enzyme, TACE, possibly by affecting membrane fluidity.

12 e phospholipid vesicles and suppressed their membrane fluidity.

13 id unsaturation, and that sHsps can regulate membrane fluidity.

14 saturated fatty acids is thought to modulate membrane fluidity.

15 e receptor complex, or increases in neuronal membrane fluidity.

16 the lipid bilayer, leading to a reduction in membrane fluidity.

17 bind bis-ANS and had little to no effect on membrane fluidity.

18 hydrophobic sites and induces a decrease in membrane fluidity.

19 ly correlated with the extent of decrease in membrane fluidity.

20 with phospholipid vesicles and suppress the membrane fluidity.

21 -arginine or tetrahydrobiopterin, or reduced membrane fluidity.

22 nterleukin 2 and -1beta production, and PBMC membrane fluidity.

23 C2-Dihydroceramide did not alter membrane fluidity.

24 less potent than native BSA in altering the membrane fluidity.

25 ith a pulse of intense light as a measure of membrane fluidity.

26 reducing LPS levels, which in turn may alter membrane fluidity.

27 ive bacteria and that loss of DolP increases membrane fluidity.

28 phylococcal membrane lipids and the agent of membrane fluidity.

29 rane-delimited manner, through modulation of membrane fluidity.

30 educed long-chain lipid content, and reduced membrane fluidity.

31 essential roles in signaling and modulating membrane fluidity.

32 r to achieve full coating due to the limited membrane fluidity.

33 s, i.e. manifested as 'patches' of increased membrane fluidity.

34 anization, organelle dysfunction and altered membrane fluidity.

35 ed for fusion, likely through an increase in membrane fluidity.

36 LDL), potentially by increasing the cellular membrane fluidity.

37 dissipation and unsaturated fatty acids for membrane fluidity.

38 al to the formation of neuronal synapses and membrane fluidity.

39 itive to the lipid composition as well as to membrane fluidity.

40 ed phospholipids, which ultimately reduce ER membrane fluidity.

41 g that both can be used by cells to maintain membrane fluidity.

42 ng, affecting cellular lipid composition and membrane fluidity.

43 sterols and phospholipids to control proper membrane fluidity.

44 nt of fluid lipid domains, affecting overall membrane fluidity.

45 ions in fatty acid composition and increased membrane fluidity.

46 y adjusting levels of lipid desaturation and membrane fluidity.

47 interaction with phospholipids is driven by membrane fluidity.

48 nse lipids, in addition to the modulation of membrane fluidity.

49 its related actin structures and the plasma membrane fluidity.

50 by a benzyl alcohol-mediated enhancement of membrane fluidity.

51 A beta aggregates affected membrane fluidity above, but not below, the lipid phase-

52 te that changes in cell membrane tension and membrane fluidity affect conformational dynamics of GPCR

53 showed that this cls mutation helps maintain membrane fluidity after freezing and thawing and improve

54 on (P=0.185), but IGL-1 prevented changes in membrane fluidity after reperfusion when compared with U

55 Increased membrane fluidity also supports hIBPLA(2) activity, sugg

56 ere associated with slower growth, decreased membrane fluidity and alterations of cell morphology.

57 ol/L) caused the opposite effect, increasing membrane fluidity and antagonizing the effect of BSA.

58 Phytosterols regulate cell membrane fluidity and are precursors for plant hormones

59 Cholesterol influences membrane fluidity and assembles lipid-rich microdomains

60 Arl3, the location of the N-terminal helix, membrane fluidity and binding, and the release of lipid

61 ng-chain polyprenols critical for apicoplast membrane fluidity and biogenesis.

62 PP species, especially fresh hIAPP, enhanced membrane fluidity and caused losses in cell viability.

63 The correlation between changes in membrane fluidity and cell viability and their lack of c

64 Membrane fluidity and charge can affect daptomycin activ

65 likely is the direct result of changes in ER membrane fluidity and composition.

66 acterial cell membranes because they control membrane fluidity and diminish passive diffusion of ions

67 a standard on-rate constant, suggesting that membrane fluidity and dynamics may strongly influence bo

68 Cooling and warming alter membrane fluidity and elicit intracellular free-calcium

69 s with palmitic acid and resulted in reduced membrane fluidity and endoplasmic reticulum stress in mo

70 dicated that both CA and CAMICs can decrease membrane fluidity and enhance lipid packing laterally.

71 nes; (b) membrane insertion is controlled by membrane fluidity and facilitates activation of IB and I

72 anchored to the SSLBMs exhibited significant membrane fluidity and have been directed into dimer asse

73 atic adjustments that serve to maintain cell membrane fluidity and hence optimal cell function.

74 Xbp1 ablation significantly reduces cellular membrane fluidity and impairs lipid homeostasis via rate

75 tic cells play important roles in modulating membrane fluidity and in cell signaling and trafficking.

76 Adjusting membrane fluidity and incorporating specific ligand-rece

77 rane insertion of hIBPLA(2) is controlled by membrane fluidity and is necessary for the full activity

78 ve stress in the pancreatic graft monitoring membrane fluidity and lipid peroxidation.

79 nd proteins profile, suggesting an impact on membrane fluidity and lipid rafts composition intervenin

80 embrane with pivotal roles in the control of membrane fluidity and maintenance of membrane microarchi

81 ding and insertion of 5-LO through increased membrane fluidity and may thereby modulate the activity

82 ug-resistant cells have suggested changes in membrane fluidity and membrane potential associated with

83 ells that express P-gp showed an increase in membrane fluidity and membrane potential.

84 ophosphatidylcholine, thereby modulating the membrane fluidity and membrane protein functions therein

85 interactions, ligand density, lipid charge, membrane fluidity and other molecular details).

86 c phospholipase A2alpha (cPLA2alpha) affects membrane fluidity and permeability by catalyzing the hyd

87 cess of eukaryotic endocytosis by regulating membrane fluidity and permeability.

88 eled cells contains useful information about membrane fluidity and polarity.

89 ein-rich and lipid-rich-and quantify how the membrane fluidity and protein-membrane affinity control

90 Consistent with this increased membrane fluidity and reduced capture, ethanol reduced r

91 AA1 binding also inhibits membrane fluidity and reduces solvent accessibility arou

92 ctured loop provides selectivity for sensing membrane fluidity and targeting to defined membrane zone

93 Instead, increased platelet membrane fluidity and the epsilon4 allele appear to make

94 In accord, membrane fluidity and the levels of certain PUFAs were d

95 phospholipids, reducing inner mitochondrial membrane fluidity and the mobility of free ubiquinone be

96 which plays an important role in modulating membrane fluidity and ultimately influence plants respon

97 Moreover, the photocontrol over membrane fluidity and, with that, mobility could eventua

98 clude cholesterol-rich nanodomains, increase membrane fluidity, and disrupt raft-like order associate

99 cous adaptation maintaining stable levels of membrane fluidity, and gel-fluid phase separation result

100 s a key factor determining lipid packing and membrane fluidity, and it must be tightly controlled to

101 rial electron transport chain, mitochondrial membrane fluidity, and mitochondrial membrane potential

102 hat cells depleted of cholesterol had higher membrane fluidity, and more uniform distribution of CD44

103 was correlated with decreased levels of UFA, membrane fluidity, and plasticity.

104 nce to the cationic defensin hNP-1, enhanced membrane fluidity, and substantially greater adhesion to

105 l as on the repulsive forces associated with membrane fluidity, and that small changes in any of thes

106 Age, increased platelet membrane fluidity, and the APOE epsilon4 allele made sig

107 to perturb membrane properties by decreasing membrane fluidity, and the membrane sensor PAQR-2 is req

108 cis-unsaturated fatty acids decrease Saureus membrane fluidity, and these altered membrane dynamics a

109 les show acidification defects and increased membrane fluidity, and this correlates with deficient fu

110 tinct membrane domains which differ in local membrane fluidity, and which severely disrupts membrane

111 actant insertion, and consequent increase in membrane fluidity, are observed to be spatially heteroge

112 t prospective evidence of increased platelet membrane fluidity as a biological risk factor for Alzhei

113 Collectively, our findings reveal increased membrane fluidity as a necessary cellular feature of met

114 his study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheime

115 his study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheime

116 , there was no correlation of the rates with membrane fluidity as measured by fluorescence polarizati

117 inding of galanin to GalR2 is independent of membrane fluidity as, like cholesterol, cholesterol anal

118 ith bipolar disorder would result in greater membrane fluidity, as detected by reductions in T(2) val

119 Using siRNA combined with lipidomics and membrane fluidity assays (FRAP and Laurdan dye staining)

120 gamma-globulin and myoglobin, decreased the membrane fluidity (assessed as changes in the steady-sta

121 ing myelin formation, cholesterol influences membrane fluidity, associates with myelin proteins such

122 esirability of maintaining the optimal outer membrane fluidity at 12 degrees C.

123 ures, but they begin to possess appreciable "membrane fluidity" at temperatures close to the minimum

124 y due to arachidonic acid-induced changes in membrane fluidity, because 11,14,17-eicosatrienoic acid

125 onstrate the importance of the difference in membrane fluidity between the gel phase DMPC and the liq

126 t cWFW instead triggers a rapid reduction of membrane fluidity both in live Bacillus subtilis cells a

127 We accounted for cargo membrane fluidity by explicitly simulating the Brownian

128 n at different temperatures and analyzed the membrane fluidity by fluorescence anisotropy measurement

129 smotic challenge shorten the cell and reduce membrane fluidity by half.

130 -stilbene derivative that enables control of membrane fluidity by light.

131 ir was dependent on ADIPOR2, which maintains membrane fluidity by promoting fatty acid desaturation a

132 We demonstrate that bile alters plasma membrane fluidity by reducing cholesterol-rich lipid mic

133 Cells maintain membrane fluidity by regulating lipid saturation, but th

134 Tuning the degree of membrane fluidity by tailoring the amount of plasticizin

135 on, but disentangling lipid composition from membrane fluidity can be obtained if time resolved spect

136 ell as the perturbation of RhoA activity and membrane fluidity, can block this HSS-induced FAK polari

137 tion that induced protein enrichment, plasma membrane fluidity changes, and elongations at the plasma

138 ution after photobleaching (FRAP) to examine membrane fluidity changes.

139 pendent of transcriptional, translational or membrane fluidity changes.

140 This review focuses on the architecture of a membrane fluidity communication network; how thermal inf

141 tropy revealed that DCA causes a decrease in membrane fluidity consistent with the increase in membra

142 itude of these effects depends on the plasma membrane fluidity, cortex adhesion, and cortical contrac

143 Decreases in membrane fluidity could hamper functioning of cell surfa

144 ane-assisted: Increasing the bacterial outer membrane fluidity decreases the population of the larger

145 mutant worms, including their characteristic membrane fluidity defects.

146 omitant measurements of mechanics and plasma membrane fluidity demonstrate that changes in actin patt

147 binding sterol (dehydroergosterol), altering membrane fluidity (diphenylhexatriene) or membrane perme

148 terol from the membrane, leading to enhanced membrane fluidity, disruption of rafts, and impaired ant

149 tion decreases cholesterol levels, increases membrane fluidity, disrupts lipid rafts, and redistribut

150 ng that these compounds likely help maintain membrane fluidity during dehydration.

151 nt of the membranes with other modulators of membrane fluidity, e.g. ethanol, did not affect galanin

152 ral nervous system (CNS) where they modulate membrane fluidity, electric signal transduction, and syn

153 tions in lipid-siRNA organization affect LNP membrane fluidity, enhancing LNP fusion with cellular me

154 We describe adaptations that enhance membrane fluidity; examine genes involved in cellular fu

155 d of highly unsaturated lipids that increase membrane fluidity, exhibit significantly higher conducta

156 Changes in lipid composition decrease membrane fluidity, F(0)F(1)-ATPase activity, and improve

157 Both of these mechanisms likely regulate membrane fluidity, facilitating the maintenance of effic

158 of cyclopropane fatty acids, (iii) increased membrane fluidity following the initial response of incr

159 Though the importance of membrane fluidity for cellular function has been well es

160 dle-cell interface and also decreases plasma membrane fluidity for the enhancement of molecular influ

161 luorescence decay can distinguish changes in membrane fluidity from changes in cholesterol content.

162 We propose a mechanism in which membrane fluidity governs the insertion of PlsX and thus

163 Our study suggests that regulation of membrane fluidity has been among the important adaptatio

164 ions of omega-3 PUFAs that increase neuronal membrane fluidity, have antioxidation activity, and rest

165 cterial flotillins are important factors for membrane fluidity homeostasis.

166 tly, Abeta aggregated at pH 6 or 7 decreased membrane fluidity in a time- and dose-dependent manner.

167 orrelation between transfection and enhanced membrane fluidity in both the lipoplex and cellular memb

168 of varying chemical structures can alter the membrane fluidity in either direction and correspondingl

169 adders with pigment stones, reflecting lower membrane fluidity in gallbladders with cholesterol stone

170 ages, and resulting in a gradual increase in membrane fluidity in individuals ranging from newborn to

171 Q8 supplementation decreased membrane fluidity in liposomes, but did not affect ProP

172 serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons.

173 thermosensor protein involved in maintaining membrane fluidity in response to changes in environmenta

174 They play an important role in modulating membrane fluidity in response to various abiotic stresse

175 mbrane fraction was accompanied by increased membrane fluidity in the alphaS overexpressing neurons.

176 olecular level such as depth of insertion or membrane fluidity in the CPP vicinity.

177 flected in corresponding differences in cell membrane fluidity in the strain pairs, with tPMP-1(r) st

178 P confirmed the r results and indicated that membrane fluidity increased while its structure became l

179 responses to calcium influx were enhanced as membrane fluidity increased.

180 hotobleaching revealed an increase in plasma membrane fluidity induced by cryptogein, but not by flag

181 ubtilis, we now show that inadequate in vivo membrane fluidity interferes with essential complex cell

182 d lipid peroxidation, resulting in decreased membrane fluidity, intracellular calcium dysregulation,

183 OS) generation, membrane lipid peroxidation, membrane fluidity, intracellular calcium regulation, pas

184 Here we show that membrane fluidity is an important determinant of membran

185 We conclude that membrane fluidity is an important physicochemical parame

186 In many organisms, regulation of membrane fluidity is crucial for acclimating to variatio

187 Furthermore, we demonstrate that very low membrane fluidity is indeed capable of triggering large-

188 In most eukaryotic cells, membrane fluidity is known to be regulated by fatty acid

189 In all cases, the membrane fluidity is maintained, indicating that both ce

190 ese results indicate that increased platelet membrane fluidity is not produced by the APOE epsilon4 a

191 Membrane fluidity is one of the important parameters inv

192 Adequate membrane fluidity is required for a variety of key cellu

193 n, a voltage-gated peptide channel for which membrane fluidity is required for activity, was reconsti

194 incompatible with ion channel function when membrane fluidity is required.

195 These alterations are reverted when membrane fluidity is restored by a chemical fluidizer.

196 Though the existence of membrane fluidity is well established, the nature of thi

197 ncommon capability of CerC16 to modulate the membrane fluidity, its curvature propensity, and the mem

198 esterol (Bdp-Chol) derivative to investigate membrane fluidity, lipid order, and partitioning in vari

199 t important, both age and increased platelet membrane fluidity made significant independent contribut

200 The ability of SM to decrease membrane fluidity may explain, at least in part, its cyt

201 In stem cell lines membrane fluidity may play a role in differentiation.

202 Cholesterol, which impedes membrane fluidity, may lower APPsol production by impedi

203 structural change is accompanied by reduced membrane fluidity (measured by infrared ellipsometry).

204 However, how AdipoR2 promotes membrane fluidity mechanistically is not clear.

205 the elo3Delta phenotype and shows increased membrane fluidity, mislocalized GFP-Ypt7, inhibited fusi

206 study highlights the critical importance of membrane fluidity modulation by desaturases in the adapt

207 pressure, and nonperturbing in that neither membrane fluidity nor order were affected, as monitored

208 g lipid-lipid interactions, lipid order, and membrane fluidity of biologically relevant L(o) domains.

209 < 0.005) less than those of cholangiocytes; membrane fluidity of hepatocytes estimated by measuring

210 vitro, the addition of a flotillin increases membrane fluidity of liposomes.

211 nt of the cells with 3 micromol/L RA reduced membrane fluidity of the cells under both high- and low-

212 The effect of Abeta aggregation state on the membrane fluidity of unilamellar liposomes was assessed

213 ut also, as we previously reported, decrease membrane fluidity on mouse polymorphonuclear leukocytes

214 activation does not reflect any nonspecific membrane fluidity or detergent effects, shows a high deg

215 pression of P-gp per se has little effect on membrane fluidity or membrane potential, and it does not

216 to lipid composition and suggest that proper membrane fluidity or plasticity is essential for an earl

217 tagonist flumazenil, which has no effects on membrane fluidity or voltage-dependent calcium channel f

218 membranes and a key molecule in controlling membrane fluidity, organization, and other physicochemic

219 a nearly universal behavior that depends on membrane fluidity parameters, such as membrane viscosity

220 onic lipids, cholesterol, sphingomyelin, and membrane fluidity play critical roles in these processes

221 anionic lipids and bilayer curvature, while membrane fluidity plays a very minor role.

222 Membrane fluidity plays an important role in cell functi

223 Membrane fluidity plays an important role in many cell f

224 It also showed no relevant effects on membrane fluidity, polarity or partitioning of the spin

225 ow levels of benzyl alcohol, which increases membrane fluidity, prevented Nup mislocalization and res

226 to the levels of untreated cells, restoring membrane fluidity, preventing the morphological changes,

227 ral effects, including increases in cellular membrane fluidity, promotion of neurite extension and in

228 to temperature drop, including regulation of membrane fluidity, protein folding, DNA topology, RNA me

229 ped molecular strategies to sense changes in membrane fluidity, provoked by a decrease in environment

230 lotillins are required for direct control of membrane fluidity rather than for the formation of prote

231 c mechanisms that include modulation of cell membrane fluidity, regulation of intracellular signaling

232 id charge, whereas fatty acid saturation and membrane fluidity remarkably influence the membrane inse

233 These dynamic changes in membrane fluidity represent the modulation of membrane t

234 sterol/phospholipid mole ratio and decreased membrane fluidity resulting in impaired muscle contracti

235 h the putative antimetastasis agents reduced membrane fluidity, resulting in decreased cell motility,

236 tent and cholesterol/phospholipid ratio, and membrane fluidity returned to normal levels.

237 ata challenge the prevailing hypothesis that membrane fluidity serves as the measured variable for re

238 ids are essential to brain functions such as membrane fluidity, signal transduction, and cell surviva

239 l properties such as acyl chain composition, membrane fluidity, surface curvature, microdomains, head

240 sion coefficient, lipid order parameter, and membrane fluidity that are sensitive to phase domains.

241 stence of an alternative pathway to regulate membrane fluidity that exploits phospholipid acyl tail l

242 Loss of flotillins leads to a decrease in membrane fluidity that in turn leads to alterations in M

243 maintains a lipid-ordered state that impacts membrane fluidity that is necessary for the low affinity

244 These changes resulted in increased plasma membrane fluidity that renders them susceptible to react

245 etter the effect that lipid chemistry has on membrane fluidity the inclusion of three different lipid

246 Finally, because SM decreases membrane fluidity, the impact of a fluidizing agent (A(2

247 n which heme and ergosterol depletion alters membrane fluidity, thereby activating Hog1 for hypoxic i

248 sing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic mechanis

249 ovides a mechanism to conditionally decrease membrane fluidity through the opposed regulation of FabH

250 may have been achieved by altering the outer membrane fluidity, thus making it more amenable for the

251 ussis adapted its fatty acid composition and membrane fluidity to a considerably lesser extent when c

252 While homeostatic adaptation of membrane fluidity to temperature variation is a ubiquito

253 l-CoA desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a

254 yme A desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a

255 (FADs) are required for maintaining the cell membrane fluidity under cold stress.

256 oad categories involving changes to the cell membrane fluidity, uptake and synthesis of compounds con

257 ependent effects of trans-resveratrol on the membrane fluidity using planar lipid bilayer and liposom

258 ial using the fluorescent probe oxonol or in membrane "fluidity" using fluorescent anisotropy probe o

259 to regulation of lipid desaturase levels and membrane fluidity via an unprecedented mode of fatty aci

260 Increased platelet membrane fluidity was associated with incident Alzheimer

261 Membrane fluidity was determined by using fluorescence p

262 Using this approach, we observed that membrane fluidity was higher when the cells were incubat

263 ct of these substances on [3H]AA release and membrane fluidity was studied in vascular myocytes and e

264 whose activities are a major determinant of membrane fluidity, we asked whether membrane-associated

265 Because tumor cells exhibit altered membrane fluidity, we suggest this might influence pHLIP

266 ber of antioxidant genes and genes affecting membrane fluidity were up-regulated in both irradiated s

267 and physical stability and for influence on membrane fluidity, when quercetin and fish oil were enca

268 stabilizes positive curvature and decreases membrane fluidity, which inhibits virus-cell membrane fu

269 Strikingly, increasing membrane fluidity with benzyl alcohol treatment prevente

270 sm measures temperature and restores optimal membrane fluidity within a single generation after a tem