ライフサイエンスコーパス: membrane receptor

1 rget genes and the increased binding of cell membrane receptor.

2 n be subsequently optimized for binding to a membrane receptor.

3 e of vitamin A from RBP4 is facilitated by a membrane receptor.

4 e multivalent effects of ligand binding to a membrane receptor.

5 cid receptor 2 (HCA(2)), a G protein-coupled membrane receptor.

6 ic pathway, consistent with activation via a membrane receptor.

7 osiderophore enterobactin via the BfeA outer membrane receptor.

8 lysosomal trafficking of an activated plasma membrane receptor.

9 ered by the binding of PA4 alone to its cell membrane receptor.

10 s with the help of a transport protein and a membrane receptor.

11 es the expression of CD44, the major HA cell membrane receptor.

12 ell to fine tune its mechanotransduction via membrane receptors.

13 perspective on the molecular recognition of membrane receptors.

14 e used to study the subunit stoichiometry of membrane receptors.

15 and stromal cells to activate corresponding membrane receptors.

16 val and motility by transducing signals from membrane receptors.

17 ge and characterize ligand binding of native membrane receptors.

18 and signalling in single-spanning eukaryotic membrane receptors.

19 icable for labeling and performing assays on membrane receptors.

20 ligand-mediated allosteric changes of these membrane receptors.

21 rotein phosphorylation cascades initiated at membrane receptors.

22 ed in the co/posttranslational processing of membrane receptors.

23 ain, have each been proposed to serve as its membrane receptors.

24 ligands in solution can induce clustering of membrane receptors.

25 eceptor family, a group of single-pass trans-membrane receptors.

26 proteins and are generally thought to act as membrane receptors.

27 out binding rates and diffusion constants of membrane receptors.

28 stabilized variants of many uncharacterized membrane receptors.

29 regulating cell-surface targeting of plasma membrane receptors.

30 cell layers through ligand-activated plasma membrane receptors.

31 gnaling complexes with effector proteins and membrane receptors.

32 leus but also transmits a signal via surface membrane receptors.

33 n ligands and previously unidentified plasma-membrane receptors.

34 nnels, scaffolding and adapter proteins, and membrane receptors.

35 to crosslink dimeric proteins and endogenous membrane receptors.

36 cells and can also modulate the activity of membrane receptors.

37 ity, endocytosis, and endocytic recycling of membrane receptors.

38 rieval, sorting, and retrograde transport of membrane receptors.

39 immune-related pathways transduced by plasma membrane receptors.

40 ated PAK1 through both the ERalpha and GPER1 membrane receptors.

41 or (FXR) and transmembrane G-protein-coupled membrane receptor 5 (TGR5), which are able to modulate t

42 Thrombomodulin (TM), an endothelial cell membrane receptor, accelerates the conversion of PC to a

43 avenger receptor class B, type I, and plasma membrane receptor activation by HDL cargo molecules.

44 elical constellations during the seven-trans-membrane receptor activation.

45 hotoactivatable ligands to characterize cell membrane receptors activity, a relevant issue for cancer

46 ssium level, but it also identifies a second membrane receptor, after angiotensin 2 receptor, that di

47 The interleukin-6 (IL-6) membrane receptor and its circulating soluble form, sIL-

48 es within the plasma membrane that segregate membrane receptors and affect membrane curvature and ves

49 n is accompanied by a profound remodeling of membrane receptors and alterations in cAMP-dependent reg

50 They bind to cell membrane receptors and are internalized.

51 tors (GPCRs) represent the largest family of membrane receptors and are responsible for regulating a

52 rs undergo endocytosis upon binding to their membrane receptors and are transported into cellular com

53 tructure determination of several classes of membrane receptors and associated oligomers.

54 dozens of other proteins that have roles as membrane receptors and channels, enzymes, signaling inte

55 y cilia detect extracellular signals through membrane receptors and channels.

56 The interactions between membrane receptors and extracellular ligands control cel

57 ion of new BAM complexes by serving as outer membrane receptors and folding factors for nascent BamA

58 genetic predisposition, which involves cell-membrane receptors and genes in second messenger signall

59 ey secrete IL-10 and express CD206 and CD163 membrane receptors and high amounts of arginase I.

60 in thought to transduce signals from various membrane receptors and intracellular proteins onto the a

61 et for anesthetics is assumed to be neuronal membrane receptors and ion channels, however new evidenc

62 nociceptors are excited by the activation of membrane receptors and ion channels.

63 rier function is tightly regulated by plasma membrane receptors and is crucial for tissue fluid homeo

64 d receptors constitute the largest family of membrane receptors and modulate almost every physiologic

65 kappaB signaling by providing a link between membrane receptors and NF-kappaB transcriptional subunit

66 viruses recognize host cells by their plasma membrane receptors and often exploit the native transloc

67 onsible for the itinerary and destination of membrane receptors and proteins moving into subcellular

68 Tyrosine phosphorylation of membrane receptors and scaffold proteins followed by rec

69 ransmitters, following the intermediation of membrane receptors and second messengers such as cyclic

70 aminergic GPCRs) belong to the class of cell membrane receptors and share many levels of similarity a

71 that crosslinks actin filaments and anchors membrane receptors and signaling intermediates.

72 Imaging native membrane receptors and testing how they interact with li

73 is require the coordinated interplay between membrane receptors and the actin cytoskeleton.

74 cellular process by which cells internalize membrane receptors and their extracellular ligands, is a

75 in complexes (i.e., quaternary structure) of membrane receptors and transporters in living cells.

76 ess, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of mon

77 not well understood how estrogens signal via membrane receptors, and how these signals impact not onl

78 tease-independent action of tPA required its membrane receptor, annexin A2.

79 Sperm ion channels and membrane receptors are attractive targets for both the d

80 Using U87MG cells, we identified the LD22-4 membrane receptor as neuropilin 1 (NRP1).

81 Humans have two forms of TREM-1: a membrane receptor, associated with the adaptor DAP12, an

82 termining affinity and kinetics of drugs for membrane receptors assume the interacting molecules are

83 They define the largest family of integral membrane receptors at the surface of the cells and const

84 protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called CD80 and CD86), is a n

85 diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic si

86 hibitors, extracellular matrix proteins, and membrane receptors, bind heparin.

87 alphavbeta3 integrin, a plasma membrane receptor, binds thyroid hormones (L-thyroxine,

88 tropin was stimulated by ligands of aberrant membrane receptors but not by corticotropin-releasing ho

89 embers of the LRRC8 family act not as plasma membrane receptors, but rather as channels that mediate

90 in multicellular organisms are maintained by membrane receptors called cell adhesion molecules (CAMs)

91 findings support the hypothesis that plasma membrane receptors can positively regulate mitochondrial

92 2 domain-containing phosphatase 1 (SHP1) or membrane receptors CD22 and/or Siglec-G, result in enhan

93 t's view of the podocyte, examining the many membrane receptors, channels, and other signaling molecu

94 mponent signal transduction system through a membrane receptor, ComD.

95 secreted from the ileum; binds to a hepatic membrane receptor complex, FGF19 receptor 4 and corecept

96 energic receptor b2 (Adrb2) and Progesterone membrane receptor component 1 (Pgrmc1), while longer Abe

97 o, for instance, act as messengers, modulate membrane receptor conformation and dynamics, and control

98 Because the determinants of membrane receptor conformational stability are still poo

99 es a focal point for fine-tuning seven trans-membrane receptor conformations activating different sig

100 optosis-inducing ligand (TRAIL) and its cell membrane receptors constitute an elaborate signaling sys

101 Single-pass membrane receptors contain extracellular domains that re

102 genes for extracellular matrix constituents, membrane receptors, contractile proteins, and associated

103 cell-matrix mechanical interactions through membrane receptors direct a wide range of cellular funct

104 Laminin and the basement membrane receptor dystroglycan function to maintain nich

105 prostaglandin E2 (PGE2) that activates four membrane receptors, EP1-EP4.

106 Complement receptor type 1 (CR1) is a membrane receptor expressed on a wide range of cells.

107 ogy, the analysis of transcription factor or membrane receptor expression is often limited by an insu

108 creased LTB4 production, and associated BLT1 membrane receptor expression.

109 diated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and

110 The Escherichia coli outer membrane receptor FepA transports ferric enterobactin (F

111 nterobactin and salmochelin across the outer membrane receptors, fepA and iroN, are needed for coloni

112 gh it is known that AtRALF1 binds the plasma membrane receptor FERONIA and conveys its signals via ph

113 We have previously established that the membrane receptor FGFR2 drives LUAD progression through

114 The plasma membrane receptor flagellin sensing2 (FLS2) confers immu

115 multifunctional protein hypothesized to be a membrane receptor for 1,25(OH)(2)D(3).

116 hese results identify a cell-cycle-regulated membrane receptor for a molecular motor and suggest a me

117 fission factor (MFF), a mitochondrial outer-membrane receptor for DRP1, the cytoplasmic guanosine tr

118 lic targeting factors that deliver them to a membrane receptor for insertion.

119 s confirmed as being the first intracellular membrane receptor for sPLA(2) by alternative Atx-affinit

120 is a component of the heterotrimeric plasma membrane receptor for the pleiotropic cytokine IL-15.

121 This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several

122 , the pyoR gene (blr3555) encoding the outer membrane receptor for transport of a ferric pyoverdine.

123 Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-alphabetaR(

124 Some bacteria also express outer membrane receptors for iron-binding proteins of the host

125 Cell membrane receptors for SDF1, bFGF, and BMP7 were up-regu

126 n that sialogangliosides and lipid rafts are membrane receptors for sKlotho and that the KL1 domain i

127 on corresponding to changes in the levels of membrane receptors for spore germinants and a protein ch

128 , the N-terminal domains bind specific inner-membrane receptors for subsequent translocation into the

129 lts highlight the complexity of plant plasma membrane receptor function and provide a tool to dissect

130 e that delivers the protein to the ER, where membrane receptors (Get1/WRB and Get2/CAML) facilitate i

131 e extracellular hemophore HasAp to the outer membrane receptor HasR is required for activation of the

132 s a carrier of the metal cofactor toward the membrane receptor HasR, and the heme-free apoprotein fis

133 elease from the hemophore HasAp to the outer-membrane receptor HasR.

134 esolution analytical methods, these integral membrane receptors have to be expressed in large quantit

135 Because membrane receptors have various roles in homeostasis, si

136 tial for analyzing the function of any other membrane receptor if a potent fluorescent ligand is avai

137 es were independently validated and included membrane receptors important for axon guidance, innate i

138 s) are the largest and most diverse group of membrane receptors in eukaryotes and detect a wide array

139 ors (GPCRs) constitute the largest family of membrane receptors in eukaryotes.

140 eptors (GPCRs) comprise the largest group of membrane receptors in eukaryotic genomes and collectivel

141 pled receptors (GPCRs), the largest class of membrane receptors in humans.

142 eptors (GPCRs) comprise the largest class of membrane receptors in humans.

143 the functional consequence of E2 binding to membrane receptors in individual neurons.

144 understanding of the molecular mechanisms of membrane receptors in signal transduction make use of ra

145 ential model system for the study of ciliary membrane receptors, including their transport.

146 to changes in their environments can rely on membrane receptors, including TRP ion channels.

147 Thus, activation of plasma membrane receptors increased the ambit of inflammatory r

148 and-induced conformational changes of plasma membrane receptors initiate signals that enable cells to

149 Activation of plasma membrane receptors initiates compartmentalized second me

150 Although this process involves cellular membrane receptor integrins, the role of integrins in my

151 ing (SERS) approach for imaging and tracking membrane receptors interacting with peptide-functionaliz

152 rates super-resolution SERS imaging to probe membrane receptor interactions in cells, providing chemi

153 for cytoplasmic adaptor proteins to organize membrane receptors into micrometer-scale signaling zones

154 Neuropilins (NRPs) are trans-membrane receptors involved in axon guidance and vascula

155 nilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sensation.

156 CRs), form the largest class of cell surface membrane receptors, involving several hundred members in

157 es, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented.

158 (PC1) and polycystin-2 (PC2), form a plasma membrane receptor-ion channel complex.

159 rticular, the spatiotemporal distribution of membrane receptors is an active field of study due to it

160 we show that cytokinin perception by plasma membrane receptors is an effective additional path for c

161 The diffusion of membrane receptors is central to many biological process

162 Dimerization of single-pass membrane receptors is essential for activation.

163 Kinase recruitment to membrane receptors is essential for signal transduction.

164 The membrane receptor isoform acts synergistically with the

165 that the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protei

166 by Catharanthus roseus RLK1-like (CrRLK1Ls) membrane receptor-kinases/LORELEI-like GLYCOLPHOSPHATIDY

167 llosteric modulators are over-represented in membrane receptors, ligand-gated ion channels and nuclea

168 essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of hea

169 ent, defense, and homeostasis rely on plasma membrane receptor-like kinases to perceive endogenous an

170 0305 interacted with lipocalin-1 interacting membrane receptor (LIMR), enhanced the interaction of LI

171 rane protein-1 (LMBR1)/lipocalin-interacting membrane receptor (LIMR)-type proteins are putative nine

172 of alga, sensory input is first detected by membrane receptors located in the cell body and then tra

173 CD48 is a membrane receptor (mCD48) on eosinophils and mast cells

174 demonstrate, at a single cell level, that E2 membrane receptors mediate the rapid signaling cascades

175 ating Vg uptake and is a promising candidate membrane receptor mediating JH regulation of patency in

176 ors (GPCRs) belong to a large superfamily of membrane receptors mediating a variety of physiological

177 Previous studies suggested that a membrane receptor might be involved in mediating vitello

178 Regulation of membrane receptor mobility tunes cellular response to ex

179 py techniques have been developed to measure membrane receptor mobility within live cells.

180 cing and immunofluorescence, we identify the membrane receptor, Nrp1, as a marker of Tw2(+) cells but

181 anchored glycoprotein Juno as the egg plasma membrane receptor of sperm Izumo1 [1,2].

182 recipitation and LC-MS/MS to screen putative membrane receptors of Dkk3a, and Integrin alpha6b (Itgal

183 KEY MESSAGE: Cytokinin membrane receptors of the Arabidopsis thaliana AHK2 and

184 of some ECM noncellular components and trans-membrane receptors of the microenvironment in PTC in ord

185 glycoprotein gp120 was being recognized by a membrane receptor on genital epithelial cells, leading t

186 The classical technique of probing membrane receptors on a millisecond scale involves placi

187 g process between multi-specific ligands and membrane receptors on cell surfaces.

188 Here, we show a way to immobilize membrane receptors on nanomechanical cantilevers so that

189 may interact with signaling molecules and/or membrane receptors on the cell surface, or even the enzy

190 ell begins with odorant molecules binding to membrane receptors on the cilia of olfactory receptor ne

191 n and cell death inhibitors on one hand, and membrane receptors on the other.

192 be extended to other dye families and other membrane receptors, opening the route to new ultrabright

193 Binding of a neurotransmitter to its membrane receptor opens an integral ion conducting pore.

194 Knowledge of membrane receptor organization is essential for understa

195 or full-length, posttranslationally modified membrane receptors, our approach offers new means to str

196 binds specifically to the G-protein-coupled membrane receptors P2Y1 and P2Y12, stimulating intracell

197 eptor conformation and dynamics, and control membrane receptor partitioning.

198 They function downstream from the membrane receptors, Patched and Smoothened, and the prim

199 se and activating the extrinsic Fas-mediated membrane receptor pathway to induce apoptosis, which is

200 nding father of a broad family of pentameric membrane receptors, paving the way for their identificat

201 cuA, PcuC, and PcuD), a TonB-dependent outer membrane receptor (PcuB), and a cytoplasmic membrane-int

202 seudomonas aeruginosa PAO1 encodes two outer membrane receptors, PhuR (Pseudomonas heme uptake) and H

203 In this study, we developed a new screening membrane receptor platform for bladder cancer cells by i

204 ) show that these highly homologous integral membrane receptors play an essential and partially redun

205 l mechanism that regulates adjustable plasma membrane receptor pools in the control of synaptic recep

206 of factors including availability of active membrane receptor pools, the composition of the 5-HT2CR

207 ochlea's base and submillisecond encoding of membrane receptor potential fluctuations in the apex for

208 le amounts of the ferric acinetobactin outer membrane receptor protein BauA while not affecting the p

209 or the production of the acinetobactin outer membrane receptor protein BauA.

210 receptor (GPCR) family is one of the largest membrane receptor protein families and controls many key

211 the interaction of colicin N with its outer membrane receptor protein OmpF.

212 or, class B type 1 (SR-B1), is a multiligand membrane receptor protein that functions as a physiologi

213 sma membrane and intracellular ion channels, membrane receptors, protein kinases, protein phosphatase

214 tors (GPCRs), which are the largest group of membrane receptor proteins and the most common targets o

215 ays involving the BfrA, BfrD, and BfrE outer membrane receptor proteins, and although Bordetella pert

216 Structures of integral membrane receptors provide valuable models for drug-rece

217 le to a wide variety of cell types and their membrane receptors, providing a novel method to determin

218 However, the outer membrane receptor Psn and TonB as well as the inner memb

219 vanced glycation end products (RAGE), a cell membrane receptor, recognizes ligands produced by cigare

220 The results demonstrated that activation of membrane receptors related to NE or Ang II caused an ini

221 rotein associations regulate the function of membrane receptors remains poorly understood.

222 f virus particle binding to host cell plasma membrane receptors, required for viral uptake.

223 was found to activate temperature-sensitive membrane receptors, resulting in an influx of calcium.

224 subcellular localization and distribution of membrane receptors, scaffolds, and signaling proteins re

225 Membrane receptor-sensed input signals affect and modula

226 d products (RAGE) is a highly expressed cell membrane receptor serving to anchor lung epithelia to ma

227 A wide range of membrane receptors signal through conformational changes

228 molecules that activate multiple nuclear and membrane receptor signaling pathways to control fed-stat

229 function in many cellular processes, such as membrane receptor signaling, endocytosis, and cell adhes

230 e spine architecture, such as impaired spine membrane receptor signalling, known to be involved in th

231 RBP4 are independent of retinol and the RBP4 membrane receptor STRA6 and occur in part via activation

232 The integral membrane receptor STRA6 mediates cellular uptake of vita

233 n can control the abundance and signaling of membrane receptors such as EGFR.

234 YKL-40 induced coordination of membrane receptor syndecan-1 and integrin alphavbeta5, a

235 ccus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand seques

236 The membrane receptor TCblR/CD320 binds transcobalamin (TC)

237 The membrane receptor (TCblR/CD320) for transcobalamin (TC)-

238 tissues, holo-RBP is recognized by a plasma membrane receptor termed STRA6, which serves a dual role

239 the microclustering of a ubiquitous class of membrane receptors, termed integrins.

240 esoid X receptor (FXR) and G protein-coupled membrane receptor TGR5 that demonstrated beneficial effe

241 TLR4, a membrane receptor that functions in complex with its acc

242 However, the membrane receptor that interacts with ligand Dkk3a to co

243 ted receptor 2 (PAR2) is a G protein-coupled membrane receptor that is activated upon cleavage of its

244 Dystroglycan is a cell membrane receptor that organizes the basement membrane b

245 oprotein related receptor 1 (LRP1), a plasma membrane receptor that regulates lipid metabolism, is el

246 uPAR is a GPI-anchored cell membrane receptor that shows increased expression in man

247 measurements of this effect, by identifying membrane receptors that do not associate in mammalian me

248 mportant drug target that includes over 1000 membrane receptors that functionally couple extracellula

249 ed receptors represent the largest family of membrane receptors that instigate signalling through nuc

250 TLRs are membrane receptors that survey the extracellular environ

251 The interaction of IFN with specific membrane receptors that transduce death-inducing signals

252 The TCR-CD3 complex is a multicomponent membrane receptor, the expression of which is tightly re

253 this approach to track the motion of single membrane receptors, the Clostridium perfringens epsilon-

254 ior work on DNA circuits for evaluating cell membrane receptors, the DNA circuits made by our archite

255 adds alpha2-6-linked sialic acids to select membrane receptors, thereby modulating receptor signalin

256 ar toxicity, even without the involvement of membrane receptors through Abeta peptide-plasma membrane

257 rol controls the activity of a wide range of membrane receptors through specific interactions and ide

258 ty of lipids to regulate the conformation of membrane receptors through specific interactions.

259 he application of single-molecule imaging to membrane receptors through the use of vesicles derived f

260 olarity information can be transduced from a membrane receptor to a key actin regulator to control co

261 framework for how microbes use a fluid outer membrane receptor to recognize and assemble kin cells in

262 nown about the molecular mechanisms coupling membrane receptors to active zone molecules during devel

263 ned here could be extended to other GPCRs or membrane receptors to better understand specific recepto

264 Scaffolding proteins interact with membrane receptors to control signaling pathways and cel

265 spanins and L6 domain proteins recruit other membrane receptors to form active signaling centers that

266 gative bacteria utilize TonB-dependent outer membrane receptors to obtain iron during infection.

267 -phase endocytosis and trafficking of plasma membrane receptors to the early endosomes as well as inh

268 oat protein named pIII and a bacterial inner-membrane receptor, TolA, which is part of the conserved

269 s effects are mediated predominantly via the membrane receptor Toll-like receptor 4 (TLR4).

270 st-translational modification that regulates membrane receptor trafficking and function.

271 ave direct implications on the regulation of membrane receptor trafficking and signaling.

272 urons, the endosomal system is essential for membrane receptor trafficking to dendrites and axons and

273 Membrane receptors, transporters, and enzymes communicat

274 volving classic signaling (IL-6->IL-6R) cell membrane receptors, transsignaling (IL-6->soluble IL-6R-

275 h is applicable to other cells with constant membrane receptor turnover.

276 We hypothesized that a plasma membrane receptor-type protein would sense the presence

277 existing technologies for quantifying plasma membrane receptor tyrosine kinases (RTKs) lack multiplex

278 Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the e

279 ectories from chromosomes, kinetochores, and membrane receptors undergoing a variety of complex motio

280 s that sensing of NHDC by a bacterial plasma membrane receptor underlies sweetener-induced growth of

281 Here, we demonstrated that ER membrane receptors VAPA and VAPB are involved in modulat

282 athway that links nuclear enzymes to ciliary membrane receptors via TULP3, describes a dynamic mechan

283 Gain of function of membrane receptor was a good strategy exploited by cance

284 However, little or none of the other membrane receptor was found to be useful as a potential

285 Because NKp46, a glycosylated membrane receptor, was necessary for dose-dependent SP-D

286 For oligomeric membrane receptors, we distinguish between a), the Leffl

287 CXCR4 is generally regarded as a plasma membrane receptor where it transmits signals that suppor

288 chanism of action, especially in the case of membrane receptors where just part of the structure has

289 t cytolysins (CDCs) utilize cholesterol as a membrane receptor, whereas a small number are restricted

290 pha (NRXN1alpha) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the

291 paired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pa

292 by a switch in selectivity toward additional membrane receptors, which are specifically expressed by

293 s can, in some cases, be imprinted with CCR9 membrane receptors, which can influence migration to the

294 challenge in life sciences is to image cell membrane receptors while characterizing their specific i

295 d nanovesicles allowed us to separate single membrane receptors while maintaining them in their physi

296 in receptor 1 (TfR1) is a ubiquitous type II membrane receptor with 61 amino acids in the N-terminal

297 FLT3 is a trans-membrane receptor with a tyrosine kinase domain which, w

298 ing proteins of GPCRs, the largest family of membrane receptors with crucial implications in virtuall

299 aging and single-particle tracking of plasma membrane receptors with single-molecule sensitivity unpe

300 s that depends on the activities of specific membrane receptors with yet unknown regulatory mechanism