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1 act to modify phosphoinositides and regulate membrane traffic.
2 utations of the surface result in defects in membrane traffic.
3 oskeleton, and biasing the directionality of membrane traffic.
4 sion, a new role of tethering factors during membrane traffic.
5 sponsible for regulating the choreography of membrane traffic.
6 suited for a multifunctional GEF involved in membrane traffic.
7 oskeleton; Rab GTPases are key regulators of membrane traffic.
8 rst time the role that this complex plays in membrane traffic.
9 inositides that regulate endosomal-lysosomal membrane traffic.
10 irect effects of acute TRP-ML1 deficiency on membrane traffic.
11 ns, including acidification, morphology, and membrane traffic.
12 ryotic cell pathways such as those mediating membrane traffic.
13 f GTPases, which are key players in cellular membrane traffic.
14 bypasses the usual route for Golgi-dependent membrane traffic.
15 uitous clathrin-coated vesicles that mediate membrane traffic.
16 Arf family and Ras superfamily that regulate membrane traffic.
17 TPase is an important regulator of endocytic membrane traffic.
18 mic locus of cytoskeletal reorganization and membrane traffic.
19 stored lamellipodial dynamics independent of membrane traffic.
20 e elucidation of the function of proteins in membrane traffic.
21 and ARF-dependent pathways in TGN to plasma membrane traffic.
22 ation is due to nonspecific perturbations in membrane traffic.
23 PITP) function in signal transduction and in membrane traffic.
24 es that can interfere with specific steps in membrane traffic.
25 ns to our understanding of the mechanisms of membrane traffic.
26 lay an important regulatory role in synaptic membrane traffic.
27 l integration point of insulin signaling and membrane traffic.
28 ction with Yip1p to mediate a common step in membrane traffic.
29 n of internal cell membranes, and a block in membrane traffic.
30 s factors potentially involved in regulating membrane traffic.
31 ted endocytosis and receptor tyrosine kinase membrane traffic.
32 ole in regulation of signal transduction and membrane traffic.
33 rucial to unravel the co-ordination of plant membrane traffic.
34 r independently of COPI- and COPII-dependent membrane traffic.
35 addition to its previously described role in membrane traffic.
36 MDs and support the central role of rafts in membrane traffic.
37 of neuronal proteins thought to function in membrane traffic.
38 in all cells suggests a fundamental role in membrane traffic.
39 eria monocytogenes (LM) modulates phagocytic membrane traffic.
40 me proteins that are important for lysosomal membrane traffic.
41 phosphoinositides play an important role in membrane traffic.
42 usually associated with trans-Golgi network membrane traffic.
43 ulation of actin cytoskeleton remodeling and membrane traffic.
44 additional proteins to ensure specificity in membrane traffic.
45 ons between the microtubule cytoskeleton and membrane traffic.
46 SNAREs were thought to ensure specificity in membrane traffic.
47 hich was shown previously to be required for membrane traffic.
48 a role in providing specificity to polarized membrane traffic.
49 n tyrosine phosphorylation via pp60c-src and membrane traffic.
50 central functions in signal transduction and membrane traffic.
51 1 (ARF1) is a key regulator of intracellular membrane traffic.
52 st homologue Uso1p have an essential role in membrane traffic.
53 lle engaged in both secretory and retrograde membrane traffic.
54 ulators of virtually every step of vesicular membrane traffic.
55 ns in the production of vesicles involved in membrane traffic.
56 topic activation in vivo and thereby disrupt membrane traffic.
57 ciates with TJs but has no known function in membrane traffic.
58 Small GTPases play a critical role in membrane traffic.
59 slocated into the host cell where they alter membrane traffic.
60 rve as a paradigm for how CK1 kinases act in membrane traffic.
61 esicles and contribute to the specificity of membrane traffic.
62 issect the role of clathrin in intracellular membrane traffic.
63 mbers that have been implicated in endocytic membrane traffic.
64 3,5)P2, lipids which regulate endo-lysosomal membrane traffic.
65 vel models for cargo-dependent regulation of membrane traffic.
66 rize functions of these structures in apical membrane traffic.
67 rates play essential roles in endo-lysosomal membrane traffic.
68 s and thus appears to play a broader role in membrane traffic.
69 roteins required for signal transduction and membrane traffic.
70 dosomal PI(4,5)P2, a key phosphoinositide in membrane traffic.
71 re the largest family of proteins regulating membrane traffic.
73 tion of Sec15p relies on functional upstream membrane traffic, activated rab protein Sec4p, and its g
76 2 and is less effective at controlling GLUT4 membrane traffic, altering its insulin-regulated respons
81 Signaling via this pathway is dependent on membrane traffic and appears to increase gradually durin
82 with a role for COPII vesicles and Hrr25 in membrane traffic and autophagosome biogenesis, hrr25 mut
85 nversions appear to confer directionality to membrane traffic and couple each stage of traffic with t
87 the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in ooc
88 characterized for its role in intracellular membrane traffic and endocytosis from the plasma membran
89 for forward and reverse genetic analysis of membrane traffic and endomembrane organisation in Arabid
90 Sec7p, a Golgi protein required for general membrane traffic and functioning as a nucleotide exchang
92 any proteins that are involved in regulating membrane traffic and have been shown to bind specificall
94 irc6Delta are enriched for genes related to membrane traffic and nuclear processes, consistent with
98 rf and Rab/Ypt GTPases coordinately regulate membrane traffic and organelle structure by regulating v
101 ctive organelle that is directly involved in membrane traffic and possibly phospholipid recycling.
103 vesicular trafficking, thus remodeling Golgi membrane traffic and redirecting Golgi-derived vesicles
104 lation factor-6 (ARF6), which is involved in membrane traffic and regulation of the cortical actin cy
108 d by post-Golgi compartments that coordinate membrane traffic and sorting of materials to the vacuole
110 of the Ras superfamily regulate cell growth, membrane traffic and the cytoskeleton, and a wide range
112 e with those of other types of intracellular membrane traffic and, in turn, support a role for tether
113 myosin teams up to drive muscle contraction, membrane traffic, and cell division in biological cells.
114 cal events, including biochemical signaling, membrane traffic, and cell motility, originate at membra
115 conclude that Sec5 is required for directed membrane traffic, and consequently for the establishment
116 to clathrin adaptors, function in post Golgi membrane traffic, and have been implicated in glioblasto
117 cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process t
118 Arfs control distinct steps in intracellular membrane traffic, and one of the Arf-activating proteins
119 inases (SFK) to perturb cellular morphology, membrane traffic, and organellar dynamics and to trigger
121 , intracellular [Ca(2+)] and pH, endocytosed membrane traffic, and the transport of other solutes.
123 ng recognition that defects in intracellular membrane traffic are a significant cause of motor neuron
124 crotubule association and the role of p22 in membrane traffic are functionally related, because N-myr
125 large multimeric assemblies that function in membrane traffic, are guanine nucleotide exchange factor
126 deficiency virus (SIV) subvert intracellular membrane traffic as part of their replication cycle.
127 ecific interactions with known components of membrane traffic as well as with diverse proteins not pr
129 ransporters) that mediate a variety of trans-membrane traffic, as well as a segment, DIxxN, that rese
131 ol 4-phosphate (PI4P) regulates biosynthetic membrane traffic at multiple steps and differentially af
132 in yeast) has been implicated in regulating membrane traffic at postinternalization steps along the
133 Golgi complex executed via Rab6 and neuronal membrane traffic at the active zone executed via RIMs.
136 g unexpected connections between nonneuronal membrane traffic at the Golgi complex executed via Rab6
139 P210, known to capture vesicles and organize membrane traffic at the Golgi, is involved in the vesicu
140 osphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome format
141 activity prior to glucose starvation primes membrane traffic at the TGN and endosomes in response to
143 further define the classical model of apical membrane traffic at the tip of elongating pollen tubes.
144 the small GTP-binding protein that regulates membrane traffic at this stage of the secretory pathway,
145 , sorting endosomes are a major crossroad of membrane traffic, at the intersection of the endocytic a
147 in this mutant are indicative of a block in membrane traffic between the ER and Golgi apparatus.
149 mily not only regulate target recognition in membrane traffic but also control other cellular functio
150 Rab3 is not in itself essential for synaptic membrane traffic but functions to modulate the basic rel
151 eins are best characterized as regulators of membrane traffic, but recent studies indicate an additio
152 rturbs several cellular processes, including membrane traffic, but the underlying mechanisms remain p
153 also find that inhibition of COPII-dependent membrane traffic by a dominant negative SAR1 mutant fail
154 osine triphosphatases regulate intracellular membrane traffic by binding specific effector proteins.
155 otein structural element that contributes to membrane traffic by either inducing or sensing membrane
156 Ps are multidomain proteins that function in membrane traffic by inactivating the GTP binding protein
157 haromyces cerevisiae is amenable to studying membrane traffic by live-cell fluorescence microscopy.
158 recent work suggests that this regulation of membrane traffic by phosphorylation also occurs postsyna
162 y of essential cellular processes, including membrane traffic, cell division, and energy metabolism;
163 t VacA-induced alterations in late endocytic membrane traffic contribute to the capacity of H. pylori
164 imental findings suggest that actin-directed membrane traffic contributes to wandering by diluting lo
166 ring migrated away from the cell middle in a membrane traffic-dependent manner, resulting in asymmetr
167 ically alters postendocytic and biosynthetic membrane traffic directed to the apical, but not the bas
169 inct functions of CHC22 relative to CHC17 in membrane traffic during muscle development, repair, and
170 AC/ROP GTPases coordinate actin dynamics and membrane traffic during polar plant cell expansion.
171 ly characterized the spatial organization of membrane traffic during tip growth by analyzing steady-s
173 point to a role for spastin in intracellular membrane traffic events and provide further evidence to
175 ted prominent actin cytoskeleton and receive membrane traffic from cognate apical or basolateral path
177 the yeast Saccharomyces cerevisiae receives membrane traffic from the secretory pathway as well as r
178 sults indicate that PKD-mediated anterograde membrane traffic from the TGN to the PM is required for
179 A role for negatively charged lipids in membrane traffic has been postulated to involve the acti
181 s and protein families generally involved in membrane traffic has been reported, despite the essentia
185 e most important discoveries in the field of membrane traffic have come from studies of Rab GTPases b
188 cument an essential role for ARF6- regulated membrane traffic in AJ disassembly and epithelial cell m
191 coordinate actin cytoskeleton mechanics and membrane traffic in cell migration via integrin beta1 ac
194 s suggest that C9ORF72 is likely to regulate membrane traffic in conjunction with Rab-GTPase switches
204 ly of membrane proteins proposed to regulate membrane traffic in neuronal and nonneuronal cells.
208 tant new information about the correction of membrane traffic in NPC cells by Rab9 overexpression and
210 ides molecular detail of how the cell alters membrane traffic in response to an external stimulus, in
214 activating protein receptor (SNARE)-mediated membrane traffic in the transport of MT1-MMP to invadopo
216 thrin plays important roles in intracellular membrane traffic including endocytosis of plasma membran
217 any neuronal-specific proteins that regulate membrane traffic, including the poorly understood small
218 r findings suggest that Grp1p may facilitate membrane traffic indirectly, possibly by maintaining Gol
219 other eukaryotes, in plants, SNARE-mediated membrane traffic influences the density of several prote
220 vesicle from its parent membrane, can label membrane-traffic intermediates and determine their desti
224 he accurate assignment of molecular roles in membrane traffic is frequently complicated by the lack o
226 pose that the proper regulation of endosomal membrane traffic is necessary for the successful complet
230 nation of actin assembly, AJ remodeling, and membrane traffic is required for the construction of a m
234 ticle (TRAPP), a large complex that mediates membrane traffic, is found in two forms (TRAPPI and -II)
235 hoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of L
236 e homologues in other types of intracellular membrane traffic, likely underlying a universal mechanis
237 tersection of several disciplines, including membrane traffic, lipid organization, synaptic signaling
238 suggest that dysfunction of Golgi-endosomal membrane traffic may contribute to ANKH-associated patho
239 umophila to manipulate and exploit phagocyte membrane traffic may suggest novel strategies for treati
243 ns on gene expression, ion channel function, membrane traffic of ion channels and receptors, and the
244 2 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose trans
245 lts strongly support a role for myosin VI in membrane traffic on secretory and endocytic pathways.
247 small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediat
248 s can now examine in detail how this ancient membrane traffic pathway contributes to these and other
249 ing key components of this broadly conserved membrane traffic pathway, yeast geneticists generated to
250 chain (CLC) subunits participate in several membrane traffic pathways involving both clathrin and ac
252 particular reference to proteins involved in membrane traffic pathways, we discuss recent advances in
256 ever, Vti1p also functions in two additional membrane traffic pathways: Vti1p interacts with the t-SN
258 our study supports the notion that polarized membrane traffic regulated by the exocyst is an essentia
259 ting protein-1 (PACS-1) is a multifunctional membrane traffic regulator that plays important roles in
261 indings define a novel step in TGN-to-plasma membrane traffic required to export MNK to the cell surf
264 rupt the apical recycling endosome (ARE) and membrane traffic, resulting in reduced surface expressio
266 b GTPases known to be involved in regulating membrane traffic; signaling molecules such as p50RhoGAP;
267 n at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and t
268 nal myosin that may play a role in vesicular membrane traffic through actin rich regions of the cytop
274 -coated vesicle formation is responsible for membrane traffic to and from the endocytic pathway durin
275 a molecular activity linking Rab23-regulated membrane traffic to cilia and planar cell polarity.
276 omplex architecture of the cell and mediates membrane traffic to control flux through subcellular com
277 erting host cell intracellular signaling and membrane traffic to down-regulate cell-surface major his
279 ctin spinoskeleton and for the regulation of membrane traffic to express functional and structural pl
280 in the endocytic pathway to couple endocytic membrane traffic to growth factor and nutrient signaling
281 This review highlights underlying themes in membrane traffic to help us refocus and solve many remai
282 as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhi
283 e actomyosin ring spatiotemporally regulates membrane traffic to promote septum-driven cytokinesis in
285 chment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polari
290 ions in YKT6 specifically affects post-Golgi membrane traffic to the vacuole, and the effects of thes
291 gs demonstrate a fundamental shift in plasma membrane traffic toward intracellular compartments while
292 ith important functions in the regulation of membrane traffic underlying tip growth associate with di
293 ained via a tightly controlled regulation of membrane traffic using a variety of different signaling
294 to regulate each of the four major steps in membrane traffic: vesicle budding, vesicle delivery, ves
295 ility that Src may play a role in regulating membrane traffic, we searched for neuronal proteins that
296 eolae show fundamentally altered patterns of membrane traffic when loaded with excess glycosphingolip
298 y-dependent mechanisms precisely synchronize membrane traffic with overall proliferation rates and co
299 agment (NTF) of CD74, which severely impairs membrane traffic within the endocytic system and leads t
300 been implicated in many processes, including membrane traffic, yet its role in cell morphology change