ライフサイエンスコーパス: membrane transporter

1 ubiquitous Na(+),K(+)-ATPase, a major plasma membrane transporter.

2 recovery of ligand binding for a multidomain membrane transporter.

3 ins and must homodimerize to form the active membrane transporter.

4 folding of the energy coupling motif of this membrane transporter.

5 couples the proton-motive force to the outer membrane transporter.

6 cific lysosomal transporter but not a plasma membrane transporter.

7 e studies on the functional dynamics of this membrane transporter.

8 CusA/CusB/CusC to form the CusCBA periplasm membrane transporter.

9 homologue that delivers glycans to the outer membrane transporter.

10 sis suggested that PEG344 serves as an inner membrane transporter.

11 th a GT-B fold, and EpsK is an alpha-helical membrane transporter.

12 induced control of ligand affinity to active membrane transporters.

13 primarily via widely expressed facilitative membrane transporters.

14 lecular mechanism of water transport through membrane transporters.

15 nsmit the proton motive force (PMF) to outer membrane transporters.

16 on/cytoskeletal proteins, scaffold proteins, membrane transporters.

17 target genes encoding metabolic enzymes and membrane transporters.

18 ong acid in collaboration with several other membrane transporters.

19 ptake in prokaryotes, are a unique family of membrane transporters.

20 rive active transport by high-affinity outer membrane transporters.

21 C complexes and structural features of inner membrane transporters.

22 use of the structural diversity of the inner membrane transporters.

23 ing factor transporters for the new class of membrane transporters.

24 ole as a regulator of structurally unrelated membrane transporters.

25 s may play distinct roles in the function of membrane transporters.

26 ient uptake before the evolution of advanced membrane transporters.

27 pace primarily through the actions of plasma membrane transporters.

28 e a large and functionally diverse family of membrane transporters.

29 major regulated renal proximal tubule apical membrane transporters.

30 re maintained by a specific system of plasma membrane transporters.

31 and bilayer lipid composition in studies of membrane transporters.

32 rmationally stored potential energy to outer membrane transporters.

33 the outer and the inner membranes, and inner membrane transporters.

34 saccharides, along with their precursors and membrane transporters.

35 ne qua non of every functional assignment to membrane transporters.

36 s suggest that U does not exclusively use Ca membrane transporters.

37 e efficiently than selenate due to different membrane transporters.

38 solute carrier 24 (SLC24A1-5) gene family of membrane transporters.

39 nts for use as cofactors requires control of membrane transporters.

40 e osteosarcoma epithelial cells, with plasma membrane transporter 1 (MCT1) tagged with an enhanced gr

41 detectable by gamma-aminobutyric acid (GABA) membrane transporter 1 immunoreactivity is lower, wherea

42 es and the degree of gamma-aminobutyric acid membrane transporter 1 innervation in each axo-axonic sy

43 1) gamma-Aminobutyric acid membrane transporter 1-positive varicosities, whose appe

44 d decarboxylase (GAD) 65 and 67; GABA plasma membrane transporter-1 (GAT-1); GABA type A (GABA(A)) re

45 of the bacterium via an alpha-helical, inner membrane transporter; a periplasmic membrane fusion prot

46 The membrane transporter ABCA1 is a key player in cholestero

47 Extracellularly, in a reaction dependent on membrane transporter ABCA1, prealpha-migrating 2.6 nm ap

48 Here we report genetic mapping of a membrane transporter (ABCC2) to a locus controlling Bt C

49 es a functional connection between the inner membrane transporter AcrB of the RND superfamily and the

50 Membrane transporters actively translocate their substra

51 rs, termed AmTrac and MepTrac, which monitor membrane transporter activity in vivo.

52 Membrane transporters, among them the calmodulin (CaM)-a

53 ailability through synergistic inhibition of membrane transporter and phase II enzyme function.

54 coelicolor to stimulate the production of a membrane transporter and proteins with homology to actin

55 lux pump, specifically in coupling the inner membrane transporter and the outer membrane exit duct.

56 , and plants tend to readjust it, regulating membrane transporters and channels.

57 Numerous membrane transporters and enzymes couple their mechanism

58 f these sequences revealed a large number of membrane transporters and enzymes of carbohydrate metabo

59 nd H(+)-coupled systems in other families of membrane transporters and enzymes.

60 Many Gram-negative outer-membrane transporters and Gram-positive lipoprotein side

61 ore-Fe(3+) complexes are recognised by outer-membrane transporters and imported into the periplasm in

62 s well as sex differences in the activity of membrane transporters and in recently discovered myocard

63 s different from those of glucose for plasma membrane transporters and intracellular enzymes; the lum

64 ed targeting and/or retaining of canalicular membrane transporters and is a critical determinant of t

65 conserved among the P-type ATPase family of membrane transporters and is located at a seemingly stra

66 abase resource of information on cytoplasmic membrane transporters and outer membrane channels in org

67 on by creating a physical link between inner membrane transporters and outer membrane channels.

68 Membrane transporters and receptors are responsible for

69 racterized, and the binding ability of outer-membrane transporters and siderophore-binding proteins f

70 re urgently needed to understand these novel membrane transporters and their contributions to health

71 ing five different databases; genes encoding membrane transporters and their regulators were enriched

72 proteins, cytoskeleton-associated proteins, membrane transporters, and enzymes, suggesting the scope

73 esents the largest group of secondary active membrane transporters, and its members transport a diver

74 n orphan gene in the SLC22 family of organic membrane transporters, and its single-nucleotide polymor

75 ations with different activities of enzymes, membrane transporters, and other functional units which

76 The biologically and clinically important membrane transporters are challenging proteins to study

77 Some membrane transporters are dual-topology dimers in which

78 Variations in intestinal antioxidant membrane transporters are implicated in the initiation a

79 K+ channels and K+-coupled membrane transporters are important targets for drug dis

80 Here, we investigated if cell membrane transporters are involved in the cellular uptak

81 In Enterobacteriaceae, several membrane transporters are involved in zinc homeostasis a

82 Membrane transporters are key determinants of therapeuti

83 Membrane transporters are key gatekeeper proteins at cel

84 Plasma membrane transporters are often downregulated by their s

85 we identify a network of inner mitochondrial membrane transporters as a hub required for synapse func

86 not only ABC transporters but other types of membrane transporters as well.

87 pH environment in bark, they seem to employ membrane transporters associated with nitrogen uptake an

88 ffusion and transport facilitated by various membrane transporters, association with serum albumin in

89 s transmembrane conductance regulator (CFTR) membrane transporter at its original plasma membrane loc

90 xamining the functional expression of plasma membrane transporters at presynaptic terminals, we aim t

91 nce that anti-HAT drugs are interacting with membrane transporters at the human BBB and suggest that

92 r Fe-S proteins, but the mitochondrial inner membrane transporter Atm1 is important to transport the

93 ltured cells by a pathway requiring the cell membrane transporter ATP-binding cassette transporter A1

94 -RLKs) and RLK superfamily members, integral membrane transporters, ATPases, soluble N-ethylmaleimide

95 endocytosis is a common control mechanism of membrane transporters avoiding excess uptake of external

96 nB, an inner membrane protein, with an outer membrane transporter based upon a recent crystal structu

97 They are composed of the inner membrane transporters belonging to one of three superfam

98 Membrane transporters belonging to the multidrug and tox

99 st, FXR expression and several FXR-dependent membrane transporters (bile salt export pump [BSEP], mul

100 Gram-negative bacteria, TonB-dependent outer-membrane transporters bind large, scarce organometallic

101 not previously recognized, including a major membrane transporter (Brittle-1 or ADP-glucose transport

102 to determine the affinity of TonB for outer membrane transporters BtuB, FecA, and FhuA.

103 Transcriptional regulation of plasma membrane transporters by internal nutrient concentration

104 rystal structures of a Yersinia pestis outer membrane transporter called FyuA and a bacterial toxin c

105 rge amounts of calcium (Ca(2+)) via an inner membrane transporter called the uniporter.

106 across the outer membrane by dedicated outer membrane transporters called CdiB.

107 c drug resistance network, expression of the membrane transporters can be regulated by Plc1p, a compo

108 Recent advances show that specialized plant membrane transporters can be used to enhance yields of s

109 Integral membrane transporters can present a challenging protein

110 as an oligopeptide transporter, is a plasma membrane transporter capable of transporting transition

111 ne operon that also encodes a putative outer membrane transporter, CdrB.

112 r of the ATP-binding cassette superfamily of membrane transporters, CFTR contains two transmembrane d

113 suggest that a putative endocannabinoid cell membrane transporter controls the cellular AEA and 2-AG

114 CPn1032 or aaxB), and a putative cytoplasmic membrane transporter (CPn1031 or aaxC).

115 TbpA is a TonB-dependent, outer membrane transporter critical for iron acquisition, whil

116 ted the crystal structures of both the inner-membrane transporter CusA and membrane fusion protein Cu

117 bed the crystal structures of both the inner membrane transporter CusA and the membrane fusion protei

118 describe the crystal structures of the inner-membrane transporter CusA in the absence and presence of

119 the cation/proton antiporter 3 family of the Membrane Transporter Database are widely distributed in

120 nsporter type 2 (VMAT2), and dopamine plasma membrane transporters (DATs) were all expressed in cereb

121 the TonB(33-239) dimer is bound to the outer membrane transporter, DEER shows that the TonB(33-239) d

122 Multidrug membrane transporters (efflux pumps) in both prokaryotes

123 There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, wh

124 er, our results support a model in which (i) membrane transporters, encoded by Pdr1 target genes act

125 le to that of other bacteria involving outer membrane transporters energized by TonB as well as plasm

126 mitochondrial outer (cPT1) and inner (cPT2) membrane transporter enzymes are specialized in acylatio

127 P-glycoprotein (P-gp) is a well-known membrane transporter expressed in a number of strategic

128 ndicated that NRT1.11 and NRT1.12 are plasma membrane transporters expressed in the companion cells o

129 NASH is known to alter hepatic membrane transporter expression and drug disposition sim

130 I metabolism, and ATP binding cassette (ABC) membrane transporter expression and function were measur

131 Cell membrane transporters facilitate the passage of nucleoba

132 main proteins and one of the most widespread membrane transporter families, the major facilitator sup

133 sporters constitute one of the most abundant membrane transporter families.

134 lated by ferric citrate binding to the outer membrane transporter FecA.

135 otein toxin that uses the TonB system (outer membrane transporter, FepA, and three cytoplasmic membra

136 cytotoxic protein that recognizes the outer membrane transporter, FepA, as a receptor and, after gai

137 We confirmed that the outer membrane transporter FetA allows gonococcal strain FA109

138 In this study, we identified a novel plasma membrane transporter for cGMP.

139 Reduced folate carrier (RFC) is the major membrane transporter for folates and antifolates in mamm

140 MsbA, the inner membrane transporter for nascent lipopolysaccharide, pre

141 ysis, we conclude that MATE1 is an essential membrane transporter for proanthocyanidin biosynthesis i

142 e receptor for the ecotropic retrovirus as a membrane transporter for the essential amino acids lysin

143 rium within BtuB, the Escherichia coli outer membrane transporter for vitamin B(12).

144 Taste buds also robustly express plasma membrane transporters for 5-HT and NE.

145 rane proton motive force to TonB-gated outer membrane transporters for active transport of nutrients

146 ECF transporters are a family of active membrane transporters for essential micronutrients, such

147 The membrane transporters for the monoamines serotonin (SERT

148 d of the co-existence of two different outer membrane transporters for the same substrate is discusse

149 These primary active membrane transporters form one of the largest families o

150 FhaC is an outer membrane transporter from Bordetella pertussis belonging

151 Several novel genes that encode membrane transporters from the ALMT and MATE families re

152 It is suggested that Membrane Transporter functionality is based on low energ

153 orm of glutamic acid decarboxylase, the GABA membrane transporter GAT-1, and the alpha 1 and delta su

154 tiagabine (0.2 mg/kg of body weight), a GABA membrane transporter (GAT1) blocker, in 17 off-medicatio

155 Membrane transporter gene expression in primary human ma

156 ous single-nucleotide polymorphisms in human membrane transporter genes (and their protein products)

157 egulation of a number of stress response and membrane transporter genes, and, as expected, greening i

158 Furthermore, two membrane transporter genes, including vacuole cation/pro

159 We find that the plasma membrane transporter GlyT2 and the intracellular enzyme

160 they mainly do not involve chemical changes, membrane transporters have been a Cinderella subject in

161 Sinusoidal membrane transporters have been shown to participate in

162 rovesicles, and direct efflux through plasma membrane transporters, have been proposed to explain the

163 midis glucose/H(+) symporter (GlcP(Se)) is a membrane transporter highly specific for glucose and a h

164 In Gram-negative bacteria, outer membrane transporters import nutrients by coupling to an

165 TRAP) transporters are a widespread class of membrane transporters in bacteria and archaea.

166 simulations performed on several classes of membrane transporters in different conformational states

167 n of all protein-altering variants of eleven membrane transporters in heterologous expression systems

168 , we analyzed the gene expression profile of membrane transporters in HNSCC.

169 size-dependent efflux kinetics of multidrug membrane transporters in single living cells.

170 es the expression of sporulation factors and membrane transporters in T. sanguinis, which is reversed

171 deiodinases, nuclear thyroid receptors, and membrane transporters in the brain and liver in patterns

172 xtracellular transport of other nutrients to membrane transporters in the core.

173 ed sequence tag contigs that encode putative membrane transporters in the economically important red

174 logenesis is not well known, and the role of membrane transporters in tubulogenesis during developmen

175 Membrane transporters, in addition to their major role a

176 ound that nifurtimox appeared to use several membrane transporters, in particular breast-cancer resis

177 rofiling revealed a striking upregulation of membrane transporters, including aquaporin water channel

178 ls and the cardiac Na/K-ATPase, a second key membrane transporter involved in the cardiac ischemia re

179 respiration are well characterized, very few membrane transporters involved in photorespiration have

180 To clarify the role of metabolic enzymes and membrane transporters involved in the disposition of bot

181 A new type of synthetic membrane transporter is described and shown to operate i

182 e transport coordinated by the efflux/influx membrane transporters is instrumental in plant developme

183 The expression of polyspecific membrane transporters is one important mechanism by whic

184 or studying how the intracellular traffic of membrane transporters is regulated.

185 One of the less well understood aspects of membrane transporters is the dynamic coupling between co

186 zed roles in proteins, but their function in membrane transporters is underappreciated.

187 XK, a putative membrane transporter, is a component of the XK/Kell comp

188 s one of the best structurally characterized membrane transporters, it is still largely unknown how t

189 ia coli, and one most complex and intriguing membrane transporters known to date.

190 D1042A showed a striking reduction in plasma membrane transporter levels.

191 ose-binding protein (MBP) and a multisubunit membrane transporter, MalFGK(2).

192 Expression levels of membrane transporters may affect the disposition, and th

193 overexpression of ATP-binding cassette (ABC) membrane transporters, mechanisms behind their up-regula

194 riptions of voltage-gated ionic currents and membrane transporters, mechanisms of calcium-induced cal

195 Membrane transporters mediate cellular uptake of nutrien

196 A highly efficient set of membrane transporters mediates the massive movement of n

197 clude genes for catabolic carbon metabolism, membrane transporters, menaquinone biosynthesis, and com

198 The integral membrane transporter MmpL10 is essential for DAT to reac

199 g a topological pattern supporting multipass membrane transporter models.

200 Membrane transporters move substrates across the membran

201 f V-ATPase activity to Pma1p, another plasma membrane transporter, Mup1p, is not internalized in a vm

202 The family of plant membrane transporters named HKT (for high-affinity K(+)

203 e process of photosynthesis to the number of membrane transporters needed to provide sugars to rapidl

204 Slc11a1 is a membrane transporter of bivalent cations that is express

205 he NPC1 gene, which encodes an intracellular membrane transporter of non-esterified cholesterol.

206 ion assay, we showed that the purified Tet38 membrane transporter of Staphylococcus aureus bound spec

207 Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in

208 actions such as its ability to block plasma membrane transporters of all monoamines, reduce dopamine

209 et essential organometallic compounds, outer membrane transporters of Gram-negative bacteria work in

210 Integral membrane transporters of the Mycobacterial Membrane Prot

211 Membrane transporters of the RND superfamily confer mult

212 ia can detect environmental iron using outer membrane transporters (OMTs), and then regulate certain

213 affect tubular transport by interacting with membrane transporters on the luminal side of tubular epi

214 ,K(+)-ATPase frequently assembles with other membrane transporters or cellular matrix proteins in spe

215 Localization of the basolateral membrane transporter, organic anion transporting polypep

216 Cells lacking the genes encoding plasma membrane transporters Pdr5 and Snq2, two targets of Pdr1

217 4A11 has been proposed to be an electrogenic membrane transporter, permeable to Na(+), H(+) (OH(-)),

218 Membrane transporters play a central role in many cellul

219 Membrane transporters play a key role in obtaining suffi

220 cs and substrate specificity, these integral membrane transporters play key roles in metal homeostasi

221 ed esters were examined as modulators of the membrane transporter proteins ABCB1 (P-gp), ABCG2 (BCRP)

222 stance arising from the activity of integral membrane transporter proteins presents a global public h

223 SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucle

224 ate the endocytosis of Tat2 and likely other membrane transporter proteins.

225 The CmeR-regulated genes encode membrane transporters, proteins involved in C4-dicarboxy

226 In Arabidopsis, the plasma membrane transporter PUT3 is important to maintain the c

227 e, we establish that the inner mitochondrial membrane transporter, pyrimidine nucleotide carrier, tra

228 member of the Major Facilitator Superfamily, membrane transporters reacting to stimuli from the exter

229 ght to function as a sodium-dependent plasma membrane transporter, recent studies localized the prote

230 enger region, the alpha-domain, and an outer membrane transporter region, the beta-domain.

231 , with IL resistance established by an inner membrane transporter, regulated by an IL-inducible repre

232 Membrane transporters rely on highly coordinated structu

233 r and antiviral chemotherapies because these membrane transporters remove the chemotherapeutics from

234 ymes responsible for TMAO catabolism and the membrane transporter required for TMAO uptake into micro

235 dation for new and exciting avenues in liver membrane transporter research.

236 esistant parasites are defective in a plasma membrane transporter responsible for drug uptake.

237 SLC39A8 is a membrane transporter responsible for manganese uptake in

238 P-Glycoprotein is a well-known membrane transporter responsible for the efflux of an am

239 TbpA is a TonB-dependent outer membrane transporter responsible for the transport of ir

240 Inactivation of abc3(+), encoding a vacuolar membrane transporter, results in hem1Delta abc3Delta mut

241 gene families (VIR, Pv-FAM-A, Pv-FAM-D), one membrane transporter (SECY), and one hypothetical protei

242 he rate of serotonin reuptake via its plasma membrane transporter (SERT).

243 folded protein response by activating the ER membrane transporter SLC33A1/AT-1, which ensures continu

244 Recent studies have identified the plasma membrane transporter SLC5A8 and the cell-surface recepto

245 a significantly increased mRNA expression of membrane transporters SLCO1A2 and SLCO1B3 and a signific

246 Integral membrane transporters, soluble lipid-binding proteins, a

247 Support for the existence of the putative membrane transporter stems primarily from pharmacologica

248 These efflux pumps consist of an inner membrane transporter such as the AcrB proton antiporter,

249 xpression of some ATP-binding cassette (ABC) membrane transporters such as ABCB1/P-glycoprotein/MDR1

250 of this protein with the inner mitochondrial membrane transporters suggested a domain structure in wh

251 ydrate utilization with TonB-dependent outer membrane transporter system) contains two major xylanase

252 y uncharacterized iron-repressed cytoplasmic membrane transporter system, fbpABC, that is required fo

253 Distinct from many plasma membrane transporters targeted to the vacuole for degrad

254 rmore, expression of the characterized outer membrane transporters TbpA, FetA and LbpA and putative t

255 YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange acr

256 transporting polypeptide 2B1 (OATP2B1) is a membrane transporter that facilitates the cellular uptak

257 ssette transporter, family 12) is a cellular membrane transporter that facilitates the delivery of gl

258 of multidrug resistance protein 1 (MDR-1), a membrane transporter that functions as an efflux pump fo

259 this study confirm that ZmALMT1 is a plasma membrane transporter that is capable of mediating electi

260 PepT1 is an intestinal epithelial apical membrane transporter that is expressed in the small inte

261 protein MlaD is known to be part of an inner membrane transporter that is important for maintenance o

262 ein, thereby affecting the functions of this membrane transporter that mediates multidrug resistance.

263 FLR1 encodes a plasma membrane transporter that mediates resistance to benomyl

264 otein (P-gp), also known as ABCB1, is a cell membrane transporter that mediates the efflux of chemica

265 Also, NcZNT1 was found to be a plasma membrane transporter that mediates Zn but not Cd, iron (

266 Na(+)/Ca(2+) exchanger (NCX) is a plasma membrane transporter that moves Ca(2+) in or out of the

267 resistance-associated protein-4 (MRP4) is a membrane transporter that regulates the cellular efflux

268 Glyt1 encodes a membrane transporter that regulates the glycine concentr

269 etylation machinery includes AT-1/SLC33A1, a membrane transporter that translocates acetyl-CoA from t

270 Membrane transporters that clear the neurotransmitter gl

271 wth and survival depend upon the activity of membrane transporters that control the movement and dist

272 cular, the identity of unidirectional plasma membrane transporters that mediate D-serine reuptake has

273 f cation diffusion facilitators, a family of membrane transporters that play a central role in regula

274 /calcium (Na(+)/Ca(2+)) exchangers (NCX) are membrane transporters that play an essential role in mai

275 NCKXs are bi-directional membrane transporters that transport 1 Ca(2+)+K(+) ions

276 Membrane transporters that use energy stored in sodium g

277 A plasma membrane transporter, the solute carrier (SLC) human mul

278 cting the symbiotic relationship between two membrane transporters, the Nicotinamide adenine dinucleo

279 nd bypass the requirement for the TonB outer membrane transporter to allow expression of xoxF1 and gr

280 vity profile and does not use the same outer-membrane transporter to enter susceptible cells.

281 ve proteomics data and molecular modeling of membrane transporters to reconcile these opposing views.

282 tein of interest is expressed with its outer membrane transporter (TpsB) protein in a flagellin-minus

283 ession as targets of the AAR pathway include membrane transporters, transcription factors from the ba

284 In these tripartite pumps an inner membrane transporter, typically an ATPase or proton anti

285 oE and multidrug resistance protein 1 (MDR1) membrane transporter up-regulation in both the mouse ast

286 Here, we review recent studies of diverse membrane transporters using computational methods, with

287 ients through high-affinity TonB-gated outer membrane transporters using energy derived from the cyto

288 s (A549), which expresses high levels of the membrane transporter, using transporter inhibition assay

289 R controls cytoplasmic chaperones and plasma membrane transporters, whereas CopR/S responds to peripl

290 The BOR proteins are integral membrane transporters which mediate efflux of boron.

291 ion sodium symporter (DASS) family of plasma membrane transporters, which contains both cotransporter

292 onformational changes in this class of outer membrane transporters, which involve modest energy diffe

293 s likely represent a universal phenomenon in membrane transporters, which is consistent with their re

294 SLC22A1 encodes a hepatic plasma membrane transporter whose role in acylcarnitine physiol

295 large-scale conformational changes of other membrane transporters whose computational investigation

296 a(+)/Ca(2+) exchangers (NCXs) are ubiquitous membrane transporters with a key role in Ca(2+) homeosta

297 Two sinusoidal membrane transporters with an established role in hepati

298 ort is mediated by a broad array of specific membrane transporters with overlapping substrate specifi

299 : a secretion pathway comprised of the outer membrane transporter ZirT, and its secreted partner, Zir

300 The plasma membrane transporter Zrt2 is essential for zinc uptake a