ライフサイエンスコーパス: membrane-spanning

1 spirin belonged to arachidonic acid pathway, membrane-spanning 4A gene family, histamine production p

2 nsmembrane conductance regulator (CFTR) is a membrane-spanning adenosine 5'-triphosphate (ATP)-bindin

3 In particular, the peptides assume a membrane-spanning alpha-helical conformation that does n

4 odel membrane protein consisting of a single membrane-spanning alpha-helix with a Green Fluorescent P

5 ading to a Y356C substitution in the seventh membrane-spanning alpha-helix, was observed in a patient

6 putative scaffold domains, which coordinate membrane-spanning amphipathic helices that form the suga

7 Cellular expression studies showed that membrane spanning and C-loop mutations produced a simila

8 ively charged linker sequence that separates membrane-spanning and cytoplasmic (YscUC) domains.

9 peatedly identified near the junction of the membrane-spanning and cytoplasmic domains of band 3, and

10 d exhibit occasional transitions between the membrane-spanning and the surface-bound configurations.

11 s governed by the rate of degradation of its membrane-spanning anti-sigma factor, RseA.

12 ntrolled by regulated degradation of RseA, a membrane-spanning anti-sigma factor.

13 e is initiated by sequential cleavage of the membrane-spanning antisigma factor, RseA.

14 ng substrate of 220 kDa)/ankyrin repeat-rich membrane spanning (ARMS) acts as a signaling platform at

15 However, designed membrane-spanning assemblies developed to date have been

16 rsin/cofactor AAA ring, forming a composite, membrane-spanning assembly.

17 yotes, metazoans require an essential single membrane-spanning auxiliary component called EMRE to for

18 been shown to be a beta-barrel containing 19 membrane spanning beta-strands and an N-terminal alpha-h

19 Tom40 is predicted to comprise a membrane-spanning beta-barrel domain with conserved alph

20 al for the functions of Toc75, followed by a membrane-spanning beta-barrel domain.

21 om a combinatorial library designed to mimic membrane-spanning beta-hairpins.

22 o 50 site-specific modifications to create a membrane-spanning beta-helical structure.

23 e only for oligomers, forming a curtain-like membrane-spanning beta-sheet.

24 Here we test the hypothesis that membrane-spanning beta-sheets can exhibit structural pla

25 e monopolar lipid hydrocarbon chains and the membrane-spanning bolalipid chains.

26 h each protomer contributes two helices to a membrane-spanning bundle.

27 r in the N3 domain that is peripheral to the membrane-spanning C domain in the dodecameric secretin P

28 g mainly in proteolytically cleaved form, as membrane-spanning C-terminal fragments of the proteins.

29 Unlike the membrane-spanning C-terminal helix from Wza, the GfcC C-

30 The membrane-spanning C-terminal regions in tail-anchored pr

31 We report the structure of a membrane-spanning Cag T4SS assembly, which we describe a

32 t Rab43 regulates the sorting of a subset of membrane-spanning cargo as they progress through the med

33 -1 has three biologically active isoforms: a membrane-spanning cell surface glycoprotein (csCSF-1), a

34 nantly expressed by fibroblasts, whereas the membrane-spanning cell-surface isoform (csCSF-1) is expr

35 A six-lobed membrane spanning cellulose synthesis complex (CSC) cont

36 mechanism by which low pH is sensed and the membrane-spanning channel is formed.

37 docytosed, such that the PA oligomer forms a membrane-spanning channel that LF and EF translocate thr

38 imately 1.1-megadalton two-chambered, double membrane-spanning channel.

39 dergo a nanomechanical change to open up the membrane-spanning channel.

40 tic-induced conformational changes in the M2 membrane-spanning, channel-lining segment using disulfid

41 average indole ring orientations within the membrane-spanning channels.

42 Chemokines bind to membrane-spanning chemokine receptors, which signal thro

43 In Escherichia coli the membrane-spanning chemosensory complexes are polar and n

44 nvelope/endoplasmic reticulum and binds to a membrane-spanning cofactor, lamina associated polypeptid

45 and 2) catalyzes pore formation by forming a membrane-spanning complex that increases curvature stres

46 oupling, which can operate directly, through membrane-spanning complexes, or indirectly, through diff

47 B7, 9 and 10 assemble into a 1.07 MegaDalton membrane-spanning core complex (CC), around which all ot

48 The H. pylori Cag T4SS includes a large membrane-spanning core complex containing five proteins,

49 shed from MIN6 cells and that the remaining membrane spanning cytoplasmic domain is processed by gam

50 s unique to the pore helix (F137) and second membrane-spanning (D173) domain of GIRK1 were identified

51 rps near the C terminus of each subunit in a membrane-spanning dimer.

52 in modulating the conformation of the first membrane spanning domain (Aleksandrov et al., 2012; Ren

53 , even though both proteins lack any obvious membrane spanning domain.

54 domain (residues approximately 1-395) and a membrane-spanning domain (MSD) (residues approximately 3

55 on of one amino acid (+1 leucine) within the membrane-spanning domain (MSD) abolished protein functio

56 larly W127 and W137, and the residues in the membrane-spanning domain (MSD) and also immediately flan

57 The membrane-spanning domain (MSD) of the envelope (Env) gly

58 The 27-residue membrane-spanning domain (MSD) of the HIV-1 glycoprotein

59 The membrane-spanning domain (MSD) of the human immunodefici

60 ution of the hydrophobicity of the F-MLV Env membrane-spanning domain (MSD) to its incorporation into

61 leotide-binding domain (NBD) followed by one membrane-spanning domain (MSD).

62 d a cytoplasmic loop (CL4) in the C-terminal membrane-spanning domain (MSD2).

63 ne expressing a PAG1 fragment that lacks the membrane-spanning domain (PAG1(TM-)) and localized to th

64 els, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containi

65 t Hrd1p interacts with substrate through its membrane-spanning domain and discriminates misfolded fro

66 type Ia transmembrane protein with a single membrane-spanning domain and without any extracellular l

67 e Golgi, the leucine heptad within the first membrane-spanning domain contributes to its trafficking,

68 However, some point mutations in AE1 membrane-spanning domain convert the electroneutral anio

69 fused to GFP demonstrate that the N-terminal membrane-spanning domain flanked by a few positively cha

70 y as a spacer between the IgV domain and the membrane-spanning domain for efficient Tvc receptor acti

71 D2 appears to be anchored with an N-terminal membrane-spanning domain into the inner envelope membran

72 Because the membrane-spanning domain is present, the full-length hHO

73 A structural model of AE1 membrane-spanning domain is proposed, and this model is

74 orylation-induced binding of cdb3-PO4 to the membrane-spanning domain of band 3 in intact cells cause

75 served at three hydrophobic positions in the membrane-spanning domain of G2 (F427, W428, and F438).

76 ded insights into the function of the single membrane-spanning domain of LRAT.

77 cessibility method (SCAM) to investigate the membrane-spanning domain structure of PfENT1 to identify

78 h a point mutation T272Y (T6'Y in the second membrane-spanning domain) to the gamma2 subunit.

79 located in the cytoplasmic loops (C loops), membrane-spanning domain, C/N terminus, and nonmissense

80 8 and a short isoform missing the N-terminal membrane-spanning domain, have different abilities to in

81 esolutive three-dimensional structure of AE1 membrane-spanning domain, in silico modeling combined wi

82 , the first cytoplasmic domain and the first membrane-spanning domain, respectively.

83 A Vpu mutant containing a scrambled membrane-spanning domain, Vpu(RD), was still able to res

84 he C-terminal cytoplasmic loop of the second membrane-spanning domain, which forms an interface with

85 Thus, the membrane-spanning domain, while dispensable for a UL138-

86 efect depends on the interaction between the membrane-spanning domain-2 ICLs and the NBDs.

87 ed maturation defect, and substituting mouse membrane-spanning domain-2 or its intracellular loops (I

88 E217G, located in the loop region of CFTR's membrane-spanning domain.

89 SIV) or 59-70 (HIV-1) residues from the gp41 membrane-spanning domain.

90 op is tempered by residue F162 in the second membrane-spanning domain.

91 lope glycoprotein topology includes a single membrane-spanning domain.

92 are anchored to a lipid surface by their own membrane-spanning domain.

93 PSS1 contains a predicted single membrane-spanning domain.

94 tions as a Cl(-) channel and consists of two membrane spanning domains (MSDs), two cytosolic nucleoti

95 Although RPE65 has no predicted membrane spanning domains, this protein predominantly as

96 ce on calnexin for proper assembly of CFTR's membrane spanning domains.

97 (NBD) and the cytoplasmic loops (CL) of the membrane-spanning domains (MSD).

98 These transporters are assembled from two membrane-spanning domains (MSDs) and two nucleotide-bind

99 membrane-proximal external region (MPER) and membrane-spanning domains (MSDs) of viral glycoproteins

100 CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding

101 of NBD1 and disruption of its interface with membrane-spanning domains (MSDs).

102 The b subunit has two membrane-spanning domains and a large hydrophilic domain

103 paralogues, they are composed of two helical membrane-spanning domains and contain a WDXXEPXXY motif.

104 vely, we demonstrate that VirB3 contains two membrane-spanning domains and that both the N and C term

105 f a truncated RocA derivative, harboring the membrane-spanning domains but not the dimerization or HA

106 eas the exchange of amino acids in predicted membrane-spanning domains caused loss of function or sho

107 While the third and fourth membrane-spanning domains of LMP1 foster its trafficking

108 of a triangular cleft lined by the M1 and M2 membrane-spanning domains of one subunit and the M2 doma

109 Steroids interact with the membrane-spanning domains of the alpha subunits of the r

110 The membrane-spanning domains of the paradigm neurotransmitt

111 Specific interactions between the helical membrane-spanning domains of transmembrane proteins play

112 ed that the first intracellular loop between membrane-spanning domains one and two and the second ext

113 wo and the second extracellular loop between membrane-spanning domains three and four of NKCC1 are ne

114 3p reside in the cytoplasm, and six putative membrane-spanning domains were identified by insertion o

115 all missense mutations were in the putative membrane-spanning domains.

116 bility of the interface between NBD1 and the membrane-spanning domains.

117 n the 114-residue loop between the M3 and M4 membrane-spanning domains.

118 el has been proposed which features multiple membrane-spanning domains.

119 ature virions, consistent with two potential membrane-spanning domains.

120 uding the conserved hydrophilic and terminal membrane-spanning domains.

121 the outer membrane and most probably enables membrane spanning electron transfer.

122 The 12 membrane-spanning endoplasmic reticulum-resident protein

123 Membrane-spanning epidermal growth factor receptor ErbB2

124 Our results indicate that both luminal and membrane-spanning ER proteins can be fully dislocated fr

125 irB1-11 and VirD4 that assemble into a large membrane-spanning exporting machine.

126 o indicates that TM1 does not integrate in a membrane-spanning fashion, but that TM12, TM123, and TM1

127 tein stress, our analysis shows that generic membrane-spanning features of the TMD are sufficient for

128 ort here an approach to producing an active, membrane-spanning form of EGFR of suitable purity, homog

129 Here, we report the design of a membrane-spanning, four-helical bundle that transports f

130 95-kDa ectodomain shed product and a 65-kDa membrane-spanning fragment, the latter of which localize

131 tion of transmembrane helices constituting a membrane-spanning furrow that provides a path for lipids

132 cterization, and structural determination of membrane-spanning G-protein-coupled receptors (GPCRs) ar

133 ead-to-head dimers that form the conducting, membrane-spanning gA channels, these sequence positions

134 Double-membrane-spanning gap junction (GJ) channels cluster int

135 is largely enthalpic in nature, whereas the membrane-spanning global minimum is favored by entropy.

136 hesis depends on the biochemical activity of membrane spanning glucan synthases encoded by the CSLH a

137 strains are generally similar and consist of membrane-spanning, glycerol dibiphytanyl glycerol tetrae

138 expressed CD133, an unusual surface-exposed membrane-spanning glycoprotein associated with CSC.

139 lin-like growth factor receptor (IGF1R) is a membrane-spanning glycoprotein of the insulin receptor f

140 Trp --> 1-methyl-tryptophan substitutions in membrane-spanning gramicidin A channels.

141 heme channel (i.e., heme binding site within membrane spanning helices) is not present in CcmC, in co

142 red a SH2 signature motif positioned between membrane-spanning helices 4 and 5.

143 Cs), which are loosely defined as containing membrane-spanning helices and processing an isoprenoid-l

144 NPC1 contains 1278 amino acids that form 13 membrane-spanning helices and three large loops that pro

145 l isomerization are coupled to the motion of membrane-spanning helices to create a G protein binding

146 LAMP-2A exists as a homotrimer in which the membrane-spanning helices wrap around each other to form

147 RNF170 is predicted to have three membrane-spanning helices, is localized to the ER membra

148 submerged in the membrane and surrounded by membrane-spanning helices.

149 ues in exofacial loop regions, as well as in membrane-spanning helices.

150 remain membrane bound owing to their single membrane-spanning helices.

151 tracellular domain and instead contains four membrane-spanning helices.

152 membrane helix organisation, composed of one membrane-spanning helix (TM) and another that penetrates

153 ryo-EM), we show that KCNE3 tucks its single-membrane-spanning helix against KCNQ1, at a location tha

154 Cleavage by S2P, within the first membrane-spanning helix of SREBP, releases the transcrip

155 reaction with regard to residues in the M3, membrane-spanning helix of the muscle acetylcholine rece

156 gral bitopic membrane proteins with a single membrane-spanning helix play a plethora of vital roles i

157 e-2 protease (S2P), which cleaves within its membrane-spanning helix to release the transcription fac

158 ys149, at the junction of IC2 and the fourth membrane-spanning helix, has intramolecular interactions

159 multiple C2 domains and a single C-terminal membrane-spanning helix.

160 It is composed of a membrane-spanning heterodimer, MalF-MalG; a homodimeric

161 The 58-amino-acid residue SSP comprises two membrane-spanning hydrophobic regions separated by a sho

162 maturation and function depend on the seven-membrane-spanning inactive rhomboid-like proteins 1 and

163 s transmembrane domain (TMD), with the seven membrane-spanning inactive Rhomboids (iRhom) 1 and 2 imp

164 to NSm, rendering the NSm topology as a two-membrane-spanning integral membrane protein.

165 The membrane-spanning ion translocator (DeltaehbF) and the l

166 with subsequent calpain activity cleaved the membrane-spanning junctional proteins occludin and E-cad

167 eptor tyrosine kinases that are activated by membrane-spanning ligands called ephrins.

168 tetraethers (GDGTs) are distinctive archaeal membrane-spanning lipids with up to eight cyclopentane r

169 E1 isoform have implicated several predicted membrane-spanning (M) helices, most notably M4, M9, and

170 acromolecules that regulate docking, and the membrane spanning macromolecules linked to these nubs ar

171 A transbilayer mechanism and membrane-spanning may be essential for the cellular upta

172 uisition systems, involving siderophores and membrane-spanning metal importers, and the biological sp

173 sonance was used to study the tryptophans in membrane-spanning model peptides from the WALP family (a

174 Prestin is a voltage-dependent membrane-spanning motor protein that confers electromoti

175 n which the periciliary layer is occupied by membrane-spanning mucins and mucopolysaccharides densely

176 he Pal/Tol system which forms a five-member, membrane-spanning, multiprotein complex that is conserve

177 46's transmembrane hydrophobic core prevents membrane spanning, obscures the N-terminal ectodomain, a

178 Few membrane-spanning OMPs of B. burgdorferi have been defin

179 The most potent variants reside in a membrane-spanning orientation, in contrast to the parent

180 e was mapped by cross-linking and EPR to the membrane-spanning part of the transmembrane domain (TMD)

181 Both the structure and the function of the membrane-spanning part of this pathway are well defined.

182 and skeletal muscle where dystrophin and its membrane-spanning partner dystroglycan distribute intrac

183 ing synthetic peptides, corresponding to the membrane-spanning parts of functional and nonfunctional

184 in lipid membranes that provide synergistic membrane-spanning paths for a rapid and selective water

185 7 emerges as a central component in a triple membrane-spanning pathway between FGFR2b or VEGFR2 and E

186 ly the geometry but also the dynamics of the membrane-spanning peptide.

187 The dynamics of membrane-spanning peptides have a strong affect on the s

188 An explanation is given as to why membrane-spanning peptides must have been the first "inf

189 e successfully applied this method to design membrane-spanning peptides targeting the transmembrane d

190 A membrane-spanning peptidoglycan recognition protein, PGR

191 single pore located at the interface between membrane-spanning pore domains from each of four subunit

192 imer, and each subunit contains a continuous membrane-spanning pore formed by the two homologous halv

193 phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory part

194 gomerizes and potentially forms the putative membrane-spanning pore to which the remainder of the PTE

195 sed ends of alpha-helices shaping the narrow membrane-spanning pore.

196 sxA inserted into the membranes and formed a membrane-spanning pore.

197 igomeric prepores that undergo conversion to membrane-spanning pores by endosomal acidification, and

198 e peptides disrupt cell integrity by forming membrane-spanning pores that ultimately lead to their de

199 omains and critical structural motifs of the membrane-spanning portions of Kv2.1 with corresponding r

200 afficking of falcipains, which include large membrane-spanning prodomains, we utilized chimeras with

201 , we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is repres

202 est that elasticity is critical for some two-membrane spanning protein complexes to cope with variati

203 Here we show that ARMS (ankyrin repeat-rich membrane spanning protein)/Kidins220, a transmembrane sc

204 e of 220 kDa (Kidins220)/ankyrin repeat-rich membrane spanning protein, mammalian target of rapamycin

205 YIPF4 is also a poorly characterized membrane spanning protein.

206 te of 220 kD (Kidins220)/ankyrin repeat-rich membrane-spanning protein (ARMS) as a novel interaction

207 Because Thy1 is not a membrane-spanning protein and, instead, complexes with s

208 is a multiprotein complex and consists of a membrane-spanning protein channel (comprising subunit ty

209 n sorting, during enucleation, creates these membrane-spanning protein deficiencies.

210 nit of the twin arginine translocase, is a 6-membrane-spanning protein exposing three periplasmic loo

211 colocalizes and coimmunoprecipitates with a membrane-spanning protein in retina, that Thy1 complexes

212 Here we show that BB0405, a conserved membrane-spanning protein of unknown function, fails to

213 The membrane-spanning protein TGBp3 is one of the three move

214 region 1-like gene (Lmbr1l), which encodes a membrane-spanning protein with no previously described f

215 ribed as a 28-kDa virulence-associated outer-membrane-spanning protein with porin-like function, subs

216 activity, and MsrQ, an integral b-type heme membrane-spanning protein, which acts as the specific el

217 emarkably, these predominantly alpha-helical membrane spanning proteins are unusually highly stable a

218 ature that renders this ubiquitous family of membrane-spanning proteins a prime target for toxins fou

219 In biology, membrane-spanning proteins are responsible for the trans

220 rough plasmodesmata, while TGB2 and TGB3 are membrane-spanning proteins associated with endoplasmic r

221 The membrane-spanning proteins DivIB and its orthologue FtsQ

222 evaluate the role of cytoplasmic domains of membrane-spanning proteins in directing trafficking thro

223 Mapping the interaction sites between membrane-spanning proteins is a key challenge in structu

224 Membrane-spanning proteins may interact with a variety o

225 ith YXXPhi elements from other cell or virus membrane-spanning proteins resulted in alterations in En

226 Connexins (Cxs) are a family of membrane-spanning proteins that form gap junction channe

227 r membrane (OM) contains single and multiple membrane-spanning proteins that need to contain signals

228 Nonenzymatic membrane-spanning proteins with unrelated primary functi

229 Like many other membrane-spanning proteins, this trimeric protein comple

230 RAGE is a single membrane spanning receptor containing a very small appro

231 ng pathogen-associated molecular patterns, a membrane spanning region and an intracellular Toll/Inter

232 t a conserved glutamine residue in the first membrane-spanning region (TM1 region) of the alpha subun

233 al domains: an N-terminal protease, a middle membrane-spanning region and a soluble C-terminal region

234 d that both the signal peptide and the first membrane-spanning region are required for insertion of t

235 well-defined active site cavities within the membrane-spanning region in each monomer interface of th

236 introduced at selected positions within the membrane-spanning region of acetyl-GGALW(5)LALALAL(12)AL

237 The membrane-spanning region of pro-Monalysin is fully burie

238 beta-sheet was also identified close to the membrane-spanning region that resembles the cytoplasmic

239 y extending from the cytosolic side into the membrane-spanning region.

240 f ion flux have been identified flanking the membrane-spanning region.

241 d form and of an inactive mutant lacking the membrane-spanning region.

242 of NarK2 structure is proposed containing 12 membrane spanning regions consistent with other members

243 nt migration entails a net shift from apolar membrane spanning regions to more polar regions of the p

244 s embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C

245 embrane alpha-helical proteins, in which the membrane-spanning regions are made up of alpha-helices.

246 drial intermembrane-facing surface, with six membrane-spanning regions interspersed by two intermembr

247 e pathway that connects the cytoplasm to the membrane-spanning regions is unknown, and functional rol

248 , thus leading to efficient labelling of the membrane-spanning regions of the protein upon irradiatio

249 In the absence of the membrane-spanning regions, lipid allostery is propagated

250 ction, we determined the entire inventory of membrane-spanning RING finger E3 ubiquitin ligases local

251 and composition from the other known double membrane-spanning secretion system that has been structu

252 rganize locally to interact closely with the membrane-spanning section of the DNA tube.

253 The N-terminal domain including the first membrane-spanning segment contains sufficient informatio

254 thod (SCAM) to map the residues in the sixth membrane-spanning segment of the CB2 cannabinoid recepto

255 al studies, Leu at the 9'-position in the M2 membrane-spanning segment was replaced with Cys in dupal

256 ting the ligand-binding domain to the fourth membrane-spanning segment, is the principal contact poin

257 smic tail on serine residues adjacent to the membrane-spanning segment, that, when mutated markedly r

258 of nsp6 transmembrane topology revealed six membrane-spanning segments and a conserved hydrophobic d

259 The membrane-spanning segments of integral membrane proteins

260 however, unlike CsgG, PelC does not possess membrane-spanning segments required for polymer export a

261 PlsY has five membrane-spanning segments with the amino terminus and t

262 oteins Tim23 and Tim17, each containing four membrane-spanning segments.

263 common catalytic core domain composed of six membrane-spanning segments.

264 ly associated with membranes but contains no membrane-spanning segments.

265 l pigment epithelium (RPE) with no predicted membrane-spanning segments.

266 and Sema6A exemplify two diverse vertebrate, membrane-spanning semaphorin classes (4 and 6) that are

267 t systems, which are typically composed of a membrane-spanning sensor histidine kinase and a cytoplas

268 an entropic spring to perturb the packing of membrane-spanning sequences that constitute the ion perm

269 ptides that match the composition of helical membrane-spanning sequences, we quantitate anomalous SDS

270 omain, providing little understanding of the membrane-spanning signal transduction domain.

271 , thus providing little understanding of the membrane-spanning signal transduction domain.

272 Biomimetic nanopores based on membrane-spanning single-walled carbon nanotubes have be

273 gatively charged membranes correlated with a membrane-spanning state of the complex according to MD s

274 partially exposed to water, rather than in a membrane-spanning state.

275 rs during cell growth and division, and cell membrane spanning structures such as flagella and secret

276 sembled from five distinct subcomplexes, the membrane-spanning (subM) and the luminal (subL) subcompl

277 etrotranslocation of the luminal domain of a membrane-spanning substrate is triggered by autoubiquiti

278 e proteins with catalytic activities against membrane-spanning substrates that require a pair of aspa

279 s constructed for a gene encoding a putative membrane-spanning subunit (ehbO).

280 o-subunit TrkA proteins lack an identifiable membrane-spanning subunit of the Trk K+ transporter.

281 PSII is composed of 17 membrane-spanning subunits and three extrinsic subunits,

282 subset of the helices observed in the larger membrane-spanning subunits of the molybdate (ModBC) and

283 receptor is an assembly of eight single-pass membrane-spanning subunits on the surface of T lymphocyt

284 The uniplex consists of three membrane-spanning subunits--mitochondrial calcium unipor

285 ne by traversing a hydrophilic groove on the membrane-spanning surface of the protein.

286 The HSPG core proteins include the membrane-spanning syndecans (SDCs), the lycosylphosphati

287 ely on a type III secretion system - a multi-membrane spanning syringe-like apparatus - for their pat

288 The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by

289 n of Fha1, an FHA domain protein, by PpkA, a membrane-spanning threonine kinase.

290 ToxR is a membrane-spanning transcription factor that coordinates

291 ong-sought-after catalytic Phi-clamp and the membrane-spanning translocation channel, and supports th

292 substrate from the binding protein MolA to a membrane-spanning translocation pathway of MolB.

293 t of the toxin, unfolds, and moves through a membrane-spanning translocon pore to reach the cytosol.

294 e (ABC) transporters comprise a family of 48 membrane-spanning transport proteins, many of which are

295 ne editing, identified the digestive vacuole membrane-spanning transporter PfMDR1 (P. falciparum mult

296 e proteins at the cytosolic interface of the membrane spanning type III secretion 'injectisome'.

297 e, the binding site of apicularen within the membrane spanning V(O) complex.

298 served in all alphaherpesviruses, is a multi-membrane spanning virion glycoprotein essential for viru

299 membrane hyperpolarization is sensed by the membrane-spanning voltage sensor domain (VSD), and the c

300 e literature, we propose a model for how the membrane-spanning YfgM protein serves as connector betwe