ライフサイエンスコーパス: membrane-spanning domain

1 located 18 amino acids or more away from the membrane spanning domain.

2 , even though both proteins lack any obvious membrane spanning domain.

3 E217G, located in the loop region of CFTR's membrane-spanning domain.

4 he lack of a recognizable signal sequence or membrane-spanning domain.

5 PSS1 contains a predicted single membrane-spanning domain.

6 ted to encode an ICAM-4 isoform, lacking the membrane-spanning domain.

7 A, has structural features indicative of the membrane-spanning domain.

8 this conserved groove and is distal from the membrane-spanning domain.

9 ptic plasma membrane via a single C-terminal membrane-spanning domain.

10 residues (Pro(595)-Gly(596)) near the second membrane-spanning domain.

11 al N-linked glycosylation sites and a single membrane-spanning domain.

12 within a region immediately adjacent to the membrane-spanning domain.

13 envelope proteins with substitutions in the membrane-spanning domain.

14 e linked to a large hydrophobic, potentially membrane-spanning domain.

15 ucine near the center of the presumed second membrane-spanning domain.

16 rface between the cytoplasmic domain and the membrane-spanning domain.

17 132-amino-acid protein containing a putative membrane-spanning domain.

18 n a region predicted to lie within the sixth membrane-spanning domain.

19 SIV) or 59-70 (HIV-1) residues from the gp41 membrane-spanning domain.

20 op is tempered by residue F162 in the second membrane-spanning domain.

21 lope glycoprotein topology includes a single membrane-spanning domain.

22 are anchored to a lipid surface by their own membrane-spanning domain.

23 Both subunits contain a single predicted membrane-spanning domain.

24 of the small Tim proteins to the hydrophobic membrane spanning domains.

25 itoylation and myristoylation) as opposed to membrane spanning domains.

26 %) were identified as containing two or more membrane spanning domains.

27 loop, between the third (M3) and fourth (M4) membrane spanning domains.

28 ce on calnexin for proper assembly of CFTR's membrane spanning domains.

29 of RLIP76, despite the lack of identifiable membrane-spanning domains.

30 at 7 of the 12 TM domains tested function as membrane-spanning domains.

31 red to a membrane by two adjacent N-terminal membrane-spanning domains.

32 suggests a model in which FATP1 has multiple membrane-spanning domains.

33 teins by the absence of putative hydrophobic membrane-spanning domains.

34 all missense mutations were in the putative membrane-spanning domains.

35 bility of the interface between NBD1 and the membrane-spanning domains.

36 ed to a membrane by two adjacent N-terminal, membrane-spanning domains.

37 he hypothetical proteins possess one or more membrane-spanning domains.

38 a 1214-residue polypeptide with 12 putative membrane-spanning domains.

39 erminal domain which contains nine potential membrane-spanning domains.

40 encode novel proteins, one of which has five membrane-spanning domains.

41 ins a sugar transport motif and 12 potential membrane-spanning domains.

42 n the 114-residue loop between the M3 and M4 membrane-spanning domains.

43 egral membrane protein with 9 to 10 putative membrane-spanning domains.

44 ino acid residues and possessing 12 putative membrane-spanning domains.

45 agonists that activate receptors with seven membrane-spanning domains.

46 gral cytoplasmic membrane protein with eight membrane-spanning domains.

47 ,035 amino acids long with several potential membrane-spanning domains.

48 amino acids that is predicted to contain two membrane-spanning domains.

49 in (Vma12p) that is predicted to contain two membrane-spanning domains.

50 a 1D-subtype amino acid sequences within the membrane-spanning domains.

51 el has been proposed which features multiple membrane-spanning domains.

52 ature virions, consistent with two potential membrane-spanning domains.

53 uding the conserved hydrophilic and terminal membrane-spanning domains.

54 surface exposed, despite a lack of classical membrane-spanning domains.

55 omains (TMDs) and three loops connecting the membrane-spanning domains.

56 (119) because a chimera that contained GIRK4 membrane-spanning domain 1 significantly reduced the add

57 GIRK1 membrane-spanning domain 1 was required for optimal glyc

58 efect depends on the interaction between the membrane-spanning domain-2 ICLs and the NBDs.

59 ed maturation defect, and substituting mouse membrane-spanning domain-2 or its intracellular loops (I

60 (Gly430) that lies N-terminal to the second membrane-spanning domain activates BNC1 and converts it

61 in modulating the conformation of the first membrane spanning domain (Aleksandrov et al., 2012; Ren

62 ural models for these proteins predict eight membrane-spanning domains alternating with hydrophilic i

63 are predominantly located in or adjacent to membrane-spanning domains, although no significant bias

64 e fourth identified molecule having multiple membrane spanning domains among mammalian type C oncoret

65 idopsis; second, to search for proteins with membrane-spanning domains among the predicted plastidial

66 These findings suggest that distal to the membrane-spanning domain, an interaction of the gp41 LLP

67 lphavbeta3, is affected by both the multiply membrane spanning domain and cholesterol.

68 cytoplasmic N-terminal domain and lacks the membrane spanning domain and the C-terminal domain.

69 structed that contained the CD4 external and membrane spanning domains and a SIV TM cytoplasmic tail

70 Both clones contained two copies each of the membrane spanning domains and nucleotide-binding folds d

71 has 634 amino acid residues with 12 putative membrane spanning domains and shows a low level of ident

72 es were predicted to encode proteins with 14 membrane spanning domains and were from 26 to 53% identi

73 P1 and TAP2, each of which has an N-terminal membrane-spanning domain and a C-terminal ABC ATPase dom

74 in that they both contain an amino-terminal membrane-spanning domain and a carboxy-terminal ATPase.

75 els, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containi

76 gene, which encodes a protein with a single membrane-spanning domain and a large presumptive extrace

77 t Hrd1p interacts with substrate through its membrane-spanning domain and discriminates misfolded fro

78 truncate the NaP(i)-IIc protein in the first membrane-spanning domain and thus likely results in a co

79 sed of proteins that are predicted to have a membrane-spanning domain and to be localized at the plas

80 type Ia transmembrane protein with a single membrane-spanning domain and without any extracellular l

81 predicted to encode a protein with multiple membrane-spanning domains and a COOH-terminal glycosylph

82 The b subunit has two membrane-spanning domains and a large hydrophilic domain

83 des two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with t

84 these regions are separated by two putative membrane-spanning domains and are 150 residues apart in

85 paralogues, they are composed of two helical membrane-spanning domains and contain a WDXXEPXXY motif.

86 lated by a receptor that does not have seven membrane-spanning domains and does not employ G-proteins

87 Pit1 and Pit2 are predicted to have 10 membrane-spanning domains and five extracellular loops.

88 e encoded by these genes contain up to eight membrane-spanning domains and four 'U-motifs' with conse

89 encodes a novel protein with seven putative membrane-spanning domains and homology to the Saccharomy

90 agonism for a chimeric receptor in which the membrane-spanning domains and intervening linkers of the

91 mino-acid integral membrane protein with six membrane-spanning domains and intracellular NH2 and COOH

92 ral amino acid transporters with 11 putative membrane-spanning domains and is a potential target to m

93 n integral membrane protein with six to nine membrane-spanning domains and is expressed in neurons th

94 PfCRT contains 10 membrane-spanning domains and is found in the digestive

95 id receptor (LTB(4)-R2) that possesses seven membrane-spanning domains and is homologous (42%) and ge

96 is a 561-amino-acid protein with 12 putative membrane-spanning domains and is ubiquitously expressed,

97 that encodes a protein with seven predicted membrane-spanning domains and other features characteris

98 Because this complex has eight membrane-spanning domains and six cytoplasmic regions, d

99 vely, we demonstrate that VirB3 contains two membrane-spanning domains and that both the N and C term

100 To examine the role of the membrane-spanning domains and the approximately 200-resi

101 uggests that PRP does not have any prominent membrane-spanning domains and thus is not typical of ABC

102 LMP-1 possesses a hydrophobic membrane spanning domain, and charged, intracellular ami

103 taining the intracellular N terminus, the S1 membrane-spanning domain, and a portion of the S1/S2 loo

104 Ig-like extracellular domains (D1 and D2), a membrane-spanning domain, and a short cytoplasmic tail.

105 ch pilI is an integral membrane protein with membrane-spanning domains, and pilG is an accessory fact

106 e observation that both cysteines within the membrane-spanning domain are accessible for acylation ha

107 xtracellular domain to channel gating in the membrane-spanning domain are discussed.

108 ix VII and position 236 in the middle of the membrane-spanning domain are not.

109 ggest that sequence differences in the first membrane-spanning domains are responsible for the differ

110 ss the intermembrane space by binding to the membrane spanning domains as shown by Tim23p peptide sca

111 LMP-1 has six membrane-spanning domains as opposed to CD40's one.

112 uence predicts that the peptide contains two membrane-spanning domains as well as a cytochrome b5-lik

113 that the PrrB polypeptide could contain six membrane-spanning domains at its amino terminus and a hy

114 features of Mcp1 included (i) six potential membrane-spanning domains at the N terminus, (ii) two pr

115 A form of BarA lacking the two N-terminal membrane-spanning domains, BarA198, autophosphorylates i

116 tail and ectodomain of the protein, with the membrane-spanning domain being less important.

117 rotein of 458 amino acids containing 9 or 10 membrane-spanning domains but has no significant similar

118 complements a mutant of LMP-1 with wild-type membrane-spanning domains but no carboxy-terminal signal

119 f a truncated RocA derivative, harboring the membrane-spanning domains but not the dimerization or HA

120 located in the cytoplasmic loops (C loops), membrane-spanning domain, C/N terminus, and nonmissense

121 eas the exchange of amino acids in predicted membrane-spanning domains caused loss of function or sho

122 acellular amino and carboxyl termini and two membrane-spanning domains connected by large extracellul

123 e Golgi, the leucine heptad within the first membrane-spanning domain contributes to its trafficking,

124 However, some point mutations in AE1 membrane-spanning domain convert the electroneutral anio

125 d that the structure of both hydrophilic and membrane-spanning domains determines the degree to which

126 missing either the Ig domain or the multiple membrane-spanning domain did not.

127 we show that the protein CaT1, which has six membrane-spanning domains, exhibits the unique biophysic

128 g4 proteins lacking the predicted C-terminal membrane-spanning domain fail to assemble into oligomers

129 Our data support a model in which two membrane-spanning domains flank a central region that is

130 fused to GFP demonstrate that the N-terminal membrane-spanning domain flanked by a few positively cha

131 e range of eukaryotes and are defined by two membrane-spanning domains flanking a conserved hydrophil

132 y as a spacer between the IgV domain and the membrane-spanning domain for efficient Tvc receptor acti

133 within a region immediately adjacent to the membrane-spanning domain for their effect on the outcome

134 Deletion of the N-terminal membrane-spanning domain from microsomal P450s 2C5 and 2

135 ructed chimeras containing extracellular and membrane-spanning domains from CD25 (Tac) and cytoplasmi

136 Their substitution with six membrane-spanning domains from the LMP-2A protein of EBV

137 In this study, a membrane-spanning domain has been identified in PFO by a

138 stitution of seven leucines in LMP-1's sixth membrane-spanning domain has no effect on its function,

139 proteins and membrane proteins with multiple membrane-spanning domains has so far been observed only

140 atpB, which encodes the a subunit of the F0 membrane-spanning domain, has a similar effect on transf

141 LMP-1's first and sixth membrane-spanning domains have multiple leucine residues

142 8 and a short isoform missing the N-terminal membrane-spanning domain, have different abilities to in

143 mplete enzyme, conformational changes in the membrane-spanning domain II, which result from proton tr

144 aspase activation, along with the absence of membrane spanning domains in bcl-X(s), may, therefore, r

145 ests a significant involvement of the second membrane-spanning domain in antagonist binding in the bi

146 antly abrogated by peptides derived from the membrane-spanning domain in gp41 and coreceptor binding

147 sites for two hemes, and a three contiguous membrane-spanning domain in the photosynthetic reaction

148 5th and 6th alpha-helices (thought to be the membrane-spanning domains in bcl-2, bcl-X(L), and bax) a

149 We have examined the role of LMP-1's membrane-spanning domains in its signaling.

150 milar to that of mammalian NCKX, having five membrane-spanning domains in the NH(2) terminus separate

151 The role of glycoprotein membrane-spanning domains in the process of membrane fus

152 se behavior, and may explain one role of the membrane-spanning domains in the proteins that mediate m

153 esolutive three-dimensional structure of AE1 membrane-spanning domain, in silico modeling combined wi

154 PGT is a broadly-expressed, 12-membrane-spanning domain integral membrane protein.

155 D2 appears to be anchored with an N-terminal membrane-spanning domain into the inner envelope membran

156 similar to Int and Inv in that the proposed membrane-spanning domain is followed by several 90-amino

157 , that the actual amino acid sequence of the membrane-spanning domain is not critical for the activit

158 Because the membrane-spanning domain is present, the full-length hHO

159 g to whether or not a third (NH(2)-terminal) membrane-spanning domain is present.

160 A structural model of AE1 membrane-spanning domain is proposed, and this model is

161 -1 that contains only its amino-terminal and membrane-spanning domains is sufficient to inhibit repor

162 oduced in yeast that, lacking the C-terminal membrane-spanning domain, is secreted directly into the

163 n, consisting almost entirely of an apparent membrane-spanning domain, it contributed significantly t

164 % identity) and contained a single potential membrane-spanning domain located near its amino terminus

165 le closed states was conferred by the second membrane-spanning domain (M2) of IRK.

166 revices penetrating into the interior of the membrane-spanning domain may allow anesthetics and alcoh

167 ves a substrate encoding the first predicted membrane-spanning domain (MP1) of the replicase polyprot

168 domain (residues approximately 1-395) and a membrane-spanning domain (MSD) (residues approximately 3

169 on of one amino acid (+1 leucine) within the membrane-spanning domain (MSD) abolished protein functio

170 larly W127 and W137, and the residues in the membrane-spanning domain (MSD) and also immediately flan

171 truncations at the carboxyl terminus of the membrane-spanning domain (MSD) have been characterized.

172 s with one nucleotide-binding domain and one membrane-spanning domain (MSD) likely work as dimers, wh

173 The membrane-spanning domain (MSD) of a number of retroviral

174 The membrane-spanning domain (MSD) of the envelope (Env) gly

175 The 27-residue membrane-spanning domain (MSD) of the HIV-1 glycoprotein

176 The membrane-spanning domain (MSD) of the human immunodefici

177 ein, Env-mu26, with an L165R mutation in the membrane-spanning domain (MSD) of TM, that exhibited dra

178 ution of the hydrophobicity of the F-MLV Env membrane-spanning domain (MSD) to its incorporation into

179 MRP1 and four other MRPs have an additional membrane-spanning domain (MSD) with a putative extracell

180 leotide-binding domain (NBD) followed by one membrane-spanning domain (MSD).

181 ator (CFTR) is a Cl- channel composed of two membrane-spanning domains (MSD), two nucleotide-binding

182 (NBD) and the cytoplasmic loops (CL) of the membrane-spanning domains (MSD).

183 The NTE contains a membrane spanning domain (MSD0) with five transmembrane

184 nd ZmMRP1 contained an additional N-terminal membrane-spanning domain (MSD0) that is typical of MRP t

185 er ABC transporters, ABCC1 has an additional membrane-spanning domain (MSD0) with a putative extracel

186 Different from Pgp, MRP1 contains an extra membrane-spanning domain (MSD1) with a putative extracel

187 minal neighbors, most essentially the second membrane-spanning domain (MSD2) but significantly, not N

188 d a cytoplasmic loop (CL4) in the C-terminal membrane-spanning domain (MSD2).

189 tions as a Cl(-) channel and consists of two membrane spanning domains (MSDs), two cytosolic nucleoti

190 ies of cDNA sequences encoding putative NHE3 membrane spanning domains (msds).

191 These transporters are assembled from two membrane-spanning domains (MSDs) and two nucleotide-bind

192 o different extracellular loops of the three membrane-spanning domains (MSDs) of the transporter.

193 membrane-proximal external region (MPER) and membrane-spanning domains (MSDs) of viral glycoproteins

194 a chloride ion channel constructed from two membrane-spanning domains (MSDs), two nucleotide-binding

195 CFTR contains two membrane-spanning domains (MSDs), two nucleotide-binding

196 of NBD1 and disruption of its interface with membrane-spanning domains (MSDs).

197 lecule having the carboxyl-terminal tail and membrane spanning domain of CBATP and the amino-terminal

198 of NBD1 believed to interact with the first membrane spanning domain of CFTR.

199 The multiply membrane spanning domain of IAP is required for complex

200 monstrated that replacing all or part of the membrane-spanning domain of a viral fusion protein with

201 terminus and two regions flanking the first membrane-spanning domain of A14.

202 Replacement of the first membrane-spanning domain of alpha1E with the correspondi

203 s revealed the location and structure of the membrane-spanning domain of AT.

204 orylation-induced binding of cdb3-PO4 to the membrane-spanning domain of band 3 in intact cells cause

205 6) representing the predicted amino-terminal membrane-spanning domain of CFTR.

206 quence similarity between a three contiguous membrane-spanning domain of cytochrome b, which contains

207 obic region immediately preceding the second membrane-spanning domain of each subunit contribute to t

208 (501), located in the hydrophobic C-terminal membrane-spanning domain of eNTPDase3, was found to be t

209 It is suggested here that the ectodomain and membrane-spanning domain of Env are directly responsible

210 served at three hydrophobic positions in the membrane-spanning domain of G2 (F427, W428, and F438).

211 eins by replacing either the first or second membrane-spanning domain of human CFTR with the equivale

212 activates effector functions of the multiply membrane-spanning domain of IAP.

213 ded insights into the function of the single membrane-spanning domain of LRAT.

214 Residues immediately after the seventh membrane-spanning domain of ODR-10 are required for loca

215 We have examined the interaction of the membrane-spanning domain of one of the membrane glycopro

216 -restricted epitope, KSPWFTTL located in the membrane-spanning domain of p15TM of AKR/Gross murine le

217 eavage is unusual because it occurs within a membrane-spanning domain of SREBP.

218 rotational diffusion models suggest that the membrane-spanning domain of that population of band 3 th

219 ocalized two myotonic mutations in the sixth membrane-spanning domain of the first repeat (IS6) regio

220 imply a direct role for the residues in the membrane-spanning domain of the murine leukemia virus en

221 d leucine (to serine) in the putative second membrane-spanning domain of the rat alpha 1(alpha L263S)

222 us with VirD4, and, further, an NH2-terminal membrane-spanning domain of VirD4 is dispensable for com

223 sn-X-Arg is conserved in the first and third membrane-spanning domains of all light-harvesting chloro

224 lpharENaC and mutations preceding the second membrane-spanning domains of alpha-, beta-, and gammarEN

225 dies demonstrating that mutations within the membrane-spanning domains of alpharENaC and mutations pr

226 aken together, our results indicate that the membrane-spanning domains of both caveolins-1 and -2 pla

227 Structural differences within the membrane-spanning domains of both V(0) and F(0) may acco

228 ta suggest that interactions between the two membrane-spanning domains of CFTR may mediate associatio

229 immediately after each of the four putative membrane-spanning domains of gK.

230 ind that both the extracellular and multiply membrane-spanning domains of IAP are necessary for syner

231 o acid protein encompassing the C-terminal 3 membrane-spanning domains of intestinal PepT1 protein, w

232 These findings together indicate that the membrane-spanning domains of LMP-1 contribute multiple f

233 While the third and fourth membrane-spanning domains of LMP1 foster its trafficking

234 of a triangular cleft lined by the M1 and M2 membrane-spanning domains of one subunit and the M2 doma

235 [125I]TID), a lipophilic probe, specific for membrane-spanning domains of proteins.

236 The membrane-spanning domains of SCAP and HMG-CoA reductase

237 chniques to define the topology of the eight membrane-spanning domains of SCAP.

238 Steroids interact with the membrane-spanning domains of the alpha subunits of the r

239 The membrane-spanning domains of the paradigm neurotransmitt

240 t any of three sites located within putative membrane-spanning domains of the transporter.

241 iral membrane, consistent with the predicted membrane-spanning domains of the unprocessed polyprotein

242 Specific interactions between the helical membrane-spanning domains of transmembrane proteins play

243 The second and third membrane-spanning domains of yeast Lcb1p, located betwee

244 ed that the first intracellular loop between membrane-spanning domains one and two and the second ext

245 ol for the production of proteins containing membrane-spanning domains or otherwise unstable gene pro

246 An activity of LMP-1's N-terminus and membrane-spanning domains other than trimerization must

247 aTFT) or (ii) a missense mutation within the membrane spanning domain (P --> L).

248 ne expressing a PAG1 fragment that lacks the membrane-spanning domain (PAG1(TM-)) and localized to th

249 hich an HR2-derived (located proximal to the membrane-spanning domain) peptide binds, thus protecting

250 They also support the thesis that membrane-spanning domains possess a sequence-dependent f

251 , the remaining family member that has three membrane-spanning domains, possesses the cardinal bioche

252 Ste14p, like all Icmts, has multiple membrane spanning domains, presenting a significant chal

253 PT1 and LePT2 genes belong to a family of 12 membrane-spanning domain proteins and show a high degree

254 Truncations or deletions of the membrane-spanning domain reduce synaptotagmin, alpha/bet

255 ate that LMP-1 has specific sequences in its membrane-spanning domains required for these activities.

256 However, the putative membrane spanning domain (residues 102-134) did not show

257 ent located near the cytoplasmic face of the membrane spanning domain (residues Lys-652 to Ala-674) t

258 , the first cytoplasmic domain and the first membrane-spanning domain, respectively.

259 teines in the hydrophobic core of the second membrane-spanning domain revealed that positions 48 and

260 Although GRASP does not harbor a predicted membrane spanning domain(s), the protein was observed to

261 acking an intact RING finger or its multiple membrane-spanning domains stabilizes CD3-delta.

262 cessibility method (SCAM) to investigate the membrane-spanning domain structure of PfENT1 to identify

263 encode a protein of 560 amino acids with 12 membrane-spanning domains, termed FLVCR.

264 otional freedom for all tryptophans in these membrane spanning domains that exceed the dynamics for t

265 ally interacts with CD9, a protein with four membrane spanning domains that is frequently coexpressed

266 th an extracellular Ig domain and a multiple membrane-spanning domain that can synergize with antigen

267 main, induces a conformational change in the membrane-spanning domain that is similar to a portion of

268 focused on a leucine heptad in LMP1's first membrane-spanning domain that was shown to be necessary

269 ch encodes a novel protein with no predicted membrane-spanning domains that is polymorphic among Arab

270 In contrast to the first membrane-spanning domain, the second and third membrane-

271 While identical in their membrane-spanning domains, the two Moody proteins differ

272 toplasmic mass by 20 degrees relative to the membrane-spanning domain; the second is a rearrangement

273 Although RPE65 has no predicted membrane spanning domains, this protein predominantly as

274 wo and the second extracellular loop between membrane-spanning domains three and four of NKCC1 are ne

275 The Delta-5 desaturase contains two membrane-spanning domains, three histidine-rich regions,

276 revealed that four of these also function as membrane-spanning domains, thus supporting an 11 TM stru

277 RMA1 involves the inability of CFTR's second membrane-spanning domain to productively interact with a

278 can also be proteolytically cleaved from its membrane-spanning domain to release a freely diffusible

279 ays the effects of cation binding within the membrane-spanning domain to the nucleotide-binding site,

280 Fusing LMP-1's N-terminus and membrane-spanning domains to CD40's C-terminus supports

281 h a point mutation T272Y (T6'Y in the second membrane-spanning domain) to the gamma2 subunit.

282 PepT1, is a member of the Slc15 family of 12 membrane-spanning domain transporters; PepT1 has proton/

283 tains a chemokine domain (CDF) attached to a membrane-spanning domain via a mucin-like stalk.

284 A Vpu mutant containing a scrambled membrane-spanning domain, Vpu(RD), was still able to res

285 omplex (which contains six to eight putative membrane-spanning domains) was rapidly degraded (t1/2 ap

286 mbrane-spanning domain, the second and third membrane-spanning domains were both required for Lcb1p s

287 constructs expressing the first two or more membrane-spanning domains were capable of co-assembling

288 3p reside in the cytoplasm, and six putative membrane-spanning domains were identified by insertion o

289 In the yeast protein, three membrane-spanning domains were identified by insertion o

290 these conformational changes extend into the membrane-spanning domain where the channel gate is locat

291 he C-terminal cytoplasmic loop of the second membrane-spanning domain, which forms an interface with

292 Thus, the membrane-spanning domain, while dispensable for a UL138-

293 kinase/phosphatase domain and the N-terminal membrane-spanning domain with six transmembrane helices

294 n is proposed in which the protein has eight membrane-spanning domains with both the N terminus and t

295 composed of three subunits, each having two membrane-spanning domains with intracellular amino and c

296 tes and encode proteins predicted to have 12 membrane-spanning domains with structural homology to kn

297 a hydropathy profile suggestive of a single membrane-spanning domain, with no apparent regions capab

298 l family members had at least four potential membrane-spanning domains, with N- and C-terminal cytopl

299 of an activity's being linked to individual membrane-spanning domains within LMP-1's polytopic trans

300 , whereas similar substitutions in its first membrane-spanning domain yielded a derivative which aggr