ライフサイエンスコーパス: membranous

1 Furthermore, comparable membranous abnormalities in cultured HACD1-deficient myo

2 ension generated by myosin motors in the sub-membranous actin cortex.

3 data with that for the structurally related membranous adenylyl cyclases (mACs) 1, 2, 5 and the puri

4 efining characteristic is the apical complex-membranous and cytoskeletal elements at the apical end o

5 module that facilitates BGIN distribution to membranous and detergent-insoluble fractions.

6 ular cells from patients with proliferative, membranous and mixed LN indicated pathways relevant to i

7 maternal age is correlated with the risk of membranous and muscular VSD in Nkx2-5(+/-) but not wild-

8 e not part of an epithelium but instead form membranous attachments to a single glial cell at the nos

9 se kinase (GSK3) activity and enhancement of membranous beta-catenin and E-cadherin proteins.

10 Membranous blebs form as a cytotoxic reaction to lymphoc

11 e to the quantity of astrocyte-derived round membranous blebs.

12 g a crucial requirement for Bmp signaling in membranous bone and cartilage development.

13 res, including ossification delay in several membranous bones and enlargement of the nasal septum or

14 into the cell, these GPCRs concentrate into membranous buds at the tips of cilia before release into

15 B3 established endoplasmic reticulum-derived membranous caps at PD orifices.

16 Cytoplasmic dynein transports membranous cargoes along microtubules, but the mechanism

17 Thus dynein recruitment to two different membranous cargoes, namely EEs and SVs, requires p25, hi

18 hin membrane-bound structures, which we term membranous carriers (MCs), approaching and fusing with t

19 ellular release of molecules encapsulated in membranous carriers, such as polymersomes.

20 In cell culture studies, membranous caveolin-1 and nuclear p53 expression was gre

21 l lines of intercellular crosstalk via these membranous cellular tubes has strong potential as a nove

22 tly described tunneling nanotubes (TNTs) are membranous channels that connect cells together and allo

23 Plasmodesmata (Pd) are membranous channels that serve as a major conduit for ce

24 ajor secretory station composed of stacks of membranous cisternae, is a central yet unsettled issue i

25 nvelope remodeling drives the formation of a membranous compartment containing the sequestered materi

26 dium development occurs inside a specialized membranous compartment termed the parasitophorous vacuol

27 The replicase proteins form membranous compartments in cells to facilitate replicati

28 resent on the prebiotic Earth assembled into membranous compartments that separate reduced solutes in

29 port properties and the de novo formation of membranous compartments within the erythrocyte cytosol.

30 tration of proteins and nucleic acids in non-membranous compartments(1,2).

31 om the endoplasmic reticulum (ER) to various membranous compartments.

32 cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, an

33 We characterised the membranous/cortical lines (102) throughout stage 5 to 10

34 ally, we categorised the localisation of the membranous/cortical proteins during cytokinesis.

35 tures in rigid cuticles, but not in soft and membranous cuticles.

36 ne and inhibited the interaction between the membranous cytochrome bc (1) complex and its redox partn

37 e that hemesbin this cytochrome and in other membranous cytochromesbact as electronic connectors for

38 on to enable the detection of a multitude of membranous, cytoplasmic and nuclear antigens in whole mo

39 terpreted as layers of lipid mineralization (membranous debris also called "lipoprotein-derived debri

40 1q IgG4 was mainly detected in subepithelial membranous deposits.

41 ceptors failed to develop outer segment (OS) membranous discs and axonemes, resulting in loss of func

42 different anatomy, with only rods containing membranous discs enclosed by the plasma membrane.

43 OSs possess many hundreds of stacked membranous disks, which capture photons and scaffold the

44 ivo resulted in significant abnormalities in membranous distribution of TJ proteins.

45 l anisotropy compared to the ones with extra membranous domains or fusions with soluble proteins.

46 f eukaryotes are associated with specialized membranous domains, termed replication organelles.

47 All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintai

48 Mechanical indentation of the membranous duct at high frequencies evokes traveling wav

49 1-mediated dissociation of beta-catenin from membranous E-cadherin, which may promote senescence bypa

50 ing DSBs still correlated with the amount of membranous EGFR (24 h: r(2) = 0.977, P < 0.001; 48 h: r(

51 er was found to correlate with the amount of membranous EGFR (r(2) = 0.877, P = 0.006).

52 ) = 0.989, P < 0.001) and with the amount of membranous EGFR (r(2) = 0.967, P < 0.001).

53 vided the necessary compartmentalization and membranous environment for RNA viruses to flourish, crea

54 dSQR exhibited higher catalytic rates in its membranous environment than in its solubilized state.

55 ion molecule (EpCAM(+)) SHPC clusters showed membranous EpCAM(+)/HNF-4alpha(+) (hepatocyte nuclear fa

56 ion stabilized in mature myelin, but overall membranous expression diminished.

57 We show membranous expression of PD-L1 in the tonsillar crypts,

58 denocarcinomas and squamous cell carcinomas, membranous expression of PD-L1 was significantly associa

59 These membranous extensions interconnect the six tunnels while

60 The slow diffusion of membranous ezrin and its interaction partners relative t

61 he CD137 axis, and presence of IL-15 (or its membranous form) and IL-21.

62 molyzed cell contents, and occasionally also membranous fragments.

63 at large fluorescent signals correlated with membranous Gag-containing structures with unknown pathol

64 pathies, including minimal change nephrosis, membranous glomerulonephritis, and IgA nephropathy.

65 = 3; psoriasis, n = 2; Graves disease, n 1; membranous glomerulonephritis, n = 2; rheumatoid arthrit

66 Membranous glomerulopathy (MG) is one of the most common

67 inimal change disease, 2 were diagnosed with membranous glomerulopathy, 1 was diagnosed with crescent

68 e showed mild proteinuria at 18-24 wk due to membranous glomerulopathy.

69 t wound healing, we investigated the role of membranous glucocorticoid receptor (mbGR) by using cell-

70 Additional GI accelerated membranous GLUT1 translocation, elevating glucose uptake

71 t SCD-1 inhibition disrupts the integrity of membranous HCV replication complexes and renders HCV RNA

72 In contrast, EBP50 was primarily membranous in confluent cell lines.

73 chemical analysis revealed cytoplasmatic and membranous integrin alpha(v)beta(3) expression in the en

74 ediate filament vimentin as an extracellular membranous interaction partner of C3.

75 We report a case of membranous IVC obstruction at the junction of hepatic an

76 d in HEK cells coexpressing TRPV5 and sKL or membranous Klotho (mKL).

77 ology, dynamics of the inner ear fluids, and membranous labyrinth deformability.

78 ted with an accumulation of endolymph in the membranous labyrinth in the inner ear.

79 sensory and nonsensory elements of the adult membranous labyrinth.

80 rance plus C4 was a good diagnostic test for membranous LN (AUC 0.75).

81 This is accompanied by enhanced membranous localization of EFF-1 and the production of e

82 Wild-type beta-catenin showed membranous localization, whereas mutant showed nuclear l

83 face of two alpha-helices to be critical for membranous localization.

84 Membranous location was confirmed by flow cytometry of v

85 ochemical features, such as N-glycosylation, membranous location, and reactivity with serum only unde

86 Here we show that membranous material for cell-plate formation initially a

87 (alphaS) but also contain vesicles and other membranous material.

88 p-viral RNA interaction, suggesting that the membranous microdomain surrounding the RdRp greatly affe

89 ine shapes, similar to multiply spin-labeled membranous Na,K-ATPase below 200 K.

90 ional motion of spin-labeled lipid chains in membranous Na,K-ATPase is investigated by spin-echo elec

91 In multiply spin-labeled membranous Na,K-ATPase, this heterogeneous population of

92 eactive oxygen species via the activation of membranous NADPH oxidase (from 15 min) and mitochondria

93 Bloodstream African trypanosomes produce membranous nanotubes that originate from the flagellar m

94 ost's autophagy machinery and the parasite's membranous nanotubular network within the parasitophorou

95 Exosomes, which are membranous nanovesicles, are actively released by cells

96 rulosclerosis (HR, 0.80; 95% CI, 0.77-0.82), membranous nephropathy (HR, 0.88; 95% CI, 0.83-0.93), me

97 nephropathy (HRa, 0.74; 95% CI, 0.59-0.92), membranous nephropathy (HRa, 0.47; 95% CI, 0.29-0.75), a

98 Most patients with idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies ag

99 1) is the major target antigen in idiopathic membranous nephropathy (iMN).

100 ed as a surrogate for long-term prognosis in membranous nephropathy (MGN), variability in proteinuria

101 D7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen

102 Six patients with primary membranous nephropathy (MN) and eight with lupus nephrit

103 Absent a remission of proteinuria, primary membranous nephropathy (MN) can lead to ESRD over many y

104 Membranous nephropathy (MN) can recur in kidney allograf

105 fies a new antigen responsible for secondary membranous nephropathy (MN) in a patient with mucopolysa

106 Membranous nephropathy (MN) is a common cause of nephrot

107 Membranous nephropathy (MN) is a common cause of nephrot

108 Membranous nephropathy (MN) is a leading cause of nephro

109 Membranous Nephropathy (MN) is a rare autoimmune cause o

110 Primary membranous nephropathy (MN) is an autoimmune disease mai

111 Membranous nephropathy (MN) is the most common cause of

112 Membranous nephropathy (MN) is the most common cause of

113 Membranous nephropathy (MN) occurs due to deposition of

114 As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively common cause o

115 A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular su

116 ssion in two-thirds of patients with primary membranous nephropathy (MN), even after other treatments

117 In membranous nephropathy (MN), which is characterized by d

118 r in the diagnosis and monitoring of primary membranous nephropathy (MN).

119 s a target for autoimmunity in patients with membranous nephropathy (MN).

120 Membranous nephropathy (MN, 24.96%) and IgA nephropathy

121 In a rat model of experimental membranous nephropathy (passive Heymann nephritis (PHN))

122 Randomized trials of rituximab in primary membranous nephropathy (PMN) have not been conducted.

123 t ( approximately 70%) patients with primary membranous nephropathy (pMN).

124 g a large cohort of patients with idiopathic membranous nephropathy according to a restrictive treatm

125 For the subset of patients with idiopathic membranous nephropathy and deteriorating excretory renal

126 In nephrotic diseases, such as membranous nephropathy and FSGS, persistent injury often

127 pressive therapy in patients with idiopathic membranous nephropathy and nephrotic syndrome.

128 rt of 117 Caucasian patients with idiopathic membranous nephropathy and nephrotic-range proteinuria u

129 (St-Cp) therapy for patients with idiopathic membranous nephropathy at high risk of progression to ES

130 Human membranous nephropathy biopsy samples showed podocyte st

131 r cohort, 15 of 154 patients with idiopathic membranous nephropathy had circulating autoantibodies to

132 About 3%-5% of adults with membranous nephropathy have autoantibodies directed agai

133 Up to 80% of patients with idiopathic membranous nephropathy have non-complement-fixing IgG4 a

134 Membranous nephropathy is a common cause of adult nephro

135 Idiopathic membranous nephropathy is an autoimmune disease.

136 pports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.

137 Membranous nephropathy leads to end-stage renal disease

138 vs IgAN, ranged from 0.49 for DN to 0.92 for membranous nephropathy or ADPKD) than by lower rates of

139 and nephrotic syndrome caused by idiopathic membranous nephropathy or focal segmental glomeruloscler

140 ruli of NTS injured mice and passive Heymann membranous nephropathy rats.

141 All patients with PLA(2)R1-associated membranous nephropathy recognize at least two epitope re

142 cohort with anti-PLA2R1-negative idiopathic membranous nephropathy recognized a glomerular protein t

143 Membranous nephropathy recurs in 48% of cases threatenin

144 use of immunosuppressive drugs in idiopathic membranous nephropathy to patients at the highest risk o

145 of immune deposit formation in experimental membranous nephropathy to the role of a microRNA in FSGS

146 n groups into five subgroups, interestingly, membranous nephropathy was the most common pathologic ty

147 We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant

148 samples from the 74 patients with idiopathic membranous nephropathy who were seropositive for anti-PL

149 pholipase A(2) receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipa

150 s renal function in patients with idiopathic membranous nephropathy with declining renal function.

151 a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localizatio

152 y in this cohort of patients with idiopathic membranous nephropathy yielded favorable outcomes while

153 (18-75 years) with biopsy-proven idiopathic membranous nephropathy, a plasma creatinine concentratio

154 and nephrotic syndrome (minimal change/FSGS, membranous nephropathy, and C3 glomerulopathies).

155 and fibrosis, IgA nephropathy and idiopathic membranous nephropathy, and kidney transplantation.

156 (PLA(2)R1) are found in 80% of patients with membranous nephropathy, and previous studies described t

157 A2R is the target of the autoimmune disease, membranous nephropathy, characterised by production of a

158 In experimental membranous nephropathy, complement C5b-9-induces glomeru

159 ase were primary FSGS, diabetic nephropathy, membranous nephropathy, immunoglobulin A nephropathy, an

160 peutic advances for patients with idiopathic membranous nephropathy, including antibody inhibition th

161 actors, compared with IgAN (referent), FSGS, membranous nephropathy, membranoproliferative GN, lupus

162 serum samples from patients with idiopathic membranous nephropathy, patients with other glomerular d

163 We randomly assigned patients who had membranous nephropathy, proteinuria of at least 5 g per

164 lomerulopathies minimal-change nephrosis and membranous nephropathy, there is an increase in Shp2 pho

165 nts with newly diagnosed PLA(2)R1-associated membranous nephropathy, we investigated the clinical rol

166 y-based minimal change nephropathy, FSGS, or membranous nephropathy, with 94% sensitivity and 92% PPV

167 A2R1) is the major autoantigen in idiopathic membranous nephropathy.

168 toantigen in 70% of patients with idiopathic membranous nephropathy.

169 S variants, in minimal change disease, or in membranous nephropathy.

170 y showed phospholipase A 2 receptor-negative membranous nephropathy.

171 he UPS depended on oxidative modification in membranous nephropathy.

172 imal-change disease and a low correlation in membranous nephropathy.

173 d human glomerular diseases, particularly in membranous nephropathy.

174 rtant advances regarding the pathogenesis of membranous nephropathy.

175 glomeruli is also elevated in patients with membranous nephropathy.

176 anomalies play a role in the pathogenesis of membranous nephropathy.

177 (PLA2R1) is the major autoantigen in primary membranous nephropathy.

178 itope spreading" determines the prognosis of membranous nephropathy.

179 peutic intervention in patients with primary membranous nephropathy.

180 It consists of two membranous (Nox2 and p22(phox)) and three cytosolic subu

181 the inferior vena cava (IVC) is infrequent, membranous obstruction of the IVC (MOIVC) being one of i

182 hough traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, sc

183 h a large and otherwise poorly characterized membranous organelle system of the presynaptic terminal,

184 other regulated Ago1 complex associates with membranous organelles and is likely an intermediate in m

185 The timely delivery of membranous organelles and macromolecules to specific loc

186 They make sperm-specific membranous organelles but fail to assemble their major s

187 eloped viruses that replicate in cytoplasmic membranous organelles called viral inclusions (VIs) wher

188 apart from each other, with microtubules and membranous organelles clustered centrally and neurofilam

189 ed cargoes and debris derived from different membranous organelles inside the cell.

190 ing MCs emerged from larger, LAMP-1-positive membranous organelles that are morphologically compatibl

191 nteractions between alpha-syn aggregates and membranous organelles, including mitochondria, the autop

192 physical contacts with all other classes of membranous organelles, including the plasma membrane (PM

193 Like membranous organelles, large-scale coassembly of macromo

194 eleased during the autophagic degradation of membranous organelles, reducing lipotoxicity.

195 protruding spikes, and precocious fusion of membranous organelles.

196 ng with tetraspanins, critical organizers of membranous organelles.

197 (P < 0.001), and preoperative extracorporeal membranous oxygenation (P = 0.023), female donor to male

198 ive ventricular assist device/extracorporeal membranous oxygenation support (P = 0.012).

199 L160 and Atp1 facilitate the assembly of the membranous part of the cpATPase in their hosts, but loss

200 r septum is a rare entity as compared to the membranous part.

201 Microvesicles are small membranous particles generated during cellular activatio

202 al mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, thr

203 nown as microvesicles (EMVs), are nano-sized membranous particles secreted from nearly all mammalian

204 entage of neoplastic cells with staining for membranous PD-L1 (proportion score).

205 Membranous PD-L1 expression in tumor and tumor-associate

206 cyclooxygenase (COX)-2, was coincident with membranous PGE(2) synthase, and was not significantly al

207 separated from the adjacent compartments by membranous processes from ensheathing glia.

208 Collectively, cav-1 is the first identified membranous protein that directly guides RNA-binding prot

209 ons, enabling templated RNA synthesis within membranous protocells.

210 This procilium consists of a membranous protrusion extending from the basal body but

211 ells communicate is through long, actin-rich membranous protrusions called tunneling nanotubes (TNTs)

212 che mediated by previously unobserved, thin, membranous protrusions of the adjacent somatic gonad cel

213 Dendritic spines are tiny membranous protrusions on the dendrites of neurons.

214 ions support BGIN-mediated inactivation of a membranous Rac1 population, which consequently inactivat

215 hetic copolymerization strategy to realize a membranous ratiometric luminescent thermometer based on

216 Positive-strand RNA viruses build extensive membranous replication compartments to support replicati

217 k the cellular machinery to form and operate membranous replication complexes.

218 us web, but had little effect on established membranous replication factories.

219 bles many host cellular proteins into unique membranous replication structures as a prerequisite for

220 nrichment of ADP-ribosylated proteins in non-membranous RNA granules.

221 Cellular non-membranous RNA-granules, P-bodies (RNA processing bodies

222 nt PD, each pore containing a desmotubule, a membranous rod derived from the cortical ER.

223 d left-sided posterolateral CDH covered by a membranous sac who had no features suggestive of BNAR or

224 diaphragmatic hernias which are covered by a membranous sac.

225 Exosomes and microvesicles (MV) are cell membranous sacs originating from multivesicular bodies a

226 Small membranous secretions from tumor cells, termed exosomes,

227 45-22.31]; P=0.013) and a difference between membranous septum length and implantation depth (DeltaMS

228 Conversely, membranous septum length and implantation depth alone we

229 ations under the left coronary cusp, but not membranous septum length nor implantation depth alone, a

230 cted, including valve implantation depth and membranous septum length, an anatomic surrogate of the d

231 ing several human pathogens, is encased in a membranous sheath of unknown function.

232 tly identified a creased and distinct glassy membranous sheet enveloping the posterior vitreous surfa

233 ent to trigger spindle assembly from ectopic membranous sites.

234 , a potent vasoconstrictor that inhibits the membranous sodium-potassium ATPase pump across cell type

235 ded RNA (dsRNA) revealed that the ER-derived membranous spherules provide the site for BBSV replicati

236 This membranous "spindle envelope" confined spindle assembly,

237 ry and immunofluorescence stainings revealed membranous ST2L expression on specific trophoblast popul

238 blinded to clinical outcome; a score >/= 2 (membranous staining in >/= 1% of cells) was considered p

239 ocal micrographs demonstrated the enveloping membranous structure identified on phase-contrast micros

240 Because this membranous structure is observed only after posterior vi

241 ive agents of malaria, possess a distinctive membranous structure of flattened alveolar vesicles supp

242 triggers the formation of large, ER-derived membranous structures and activates the UPR, a set of si

243 in TgCRND8 brain where lipids accumulate as membranous structures and lipid droplets within giant ne

244 FA0210c plays a role in the formation of the membranous structures and nutrient phospholipid transfer

245 often found to associate with other cellular membranous structures and vary in size in a given cell,

246 Plant virus-induced membranous structures are motile, and this intracellular

247 e p62, accumulation of abnormal intra-axonal membranous structures bearing the autophagy protein LC3,

248 Tunneling nanotubes (TNTs) are actin-based membranous structures bridging distant cells for interce

249 nutrients and macromolecules through tubular membranous structures called nanotubes.

250 ed on the endoplasmic reticulum (ER)-derived membranous structures closely juxtaposed to the lipid dr

251 Membranous structures derived from various organelles ar

252 of plus-stranded RNA viruses takes place on membranous structures derived from various organelles in

253 ncer cells, where it interacts with specific membranous structures in a temporally and spatially stab

254 with positive-sense RNA genomes replicate on membranous structures in the cytoplasm called replicatio

255 system involves long-known parasite-derived membranous structures in the host cell cytosol, called M

256 been analyzed, foremost because the fragile membranous structures in the inner ear are hard to visua

257 roscopy of infected cells validated numerous membranous structures inside bacteria-containing inclusi

258 It shows divergent membranous structures that are continuously transforming

259 induce the formation of novel intracellular membranous structures that provide an optimum environmen

260 smallest LDs was nearly free of ER and other membranous structures while those with larger LDs contai

261 f P62(+)/ubiquitin(+) inclusions or abnormal membranous structures, which are observed in mice lackin

262 G) and the activity of DAG kinases (DGKs) in membranous structures.

263 todiacylglycerol with carotenoids along with membranous subcellular structures.

264 TPase either are restricted to targeting one membranous subunit of V-ATPase or have poorly understood

265 pse, lung surfactant (LS) develops a complex membranous system at the respiratory surface.

266 This mechanism relies on a membranous system surrounding the mitotic spindle that d

267 es against the constraint of a thin, elastic membranous tissue, the dorsal mesentery.

268 ticulum, secretory proteins traverse several membranous transport compartments before reaching their

269 Further, the presence of membranous tubules transiently connecting PDGs is reveal

270 Tunneling nanotubes (TNT) are thin, membranous, tunnel-like cell-to-cell connections, but th

271 ents undergoing RTS has shown an increase in membranous urethral length and elevation of the external

272 ac defects including hypoplastic myocardium, membranous ventricular septal defect, and double outlet

273 standing cardiac outflow tract alignment and membranous ventricular septal defects.

274 In eukaryotic cells, membranous vesicles and organelles are transported by en

275 sections of infected cells revealed numerous membranous vesicles inside inclusions, as well as multiv

276 The cellular release of membranous vesicles known as extracellular vesicles (EVs

277 Exosomes are small membranous vesicles secreted into body fluids by multipl

278 xtracellular vesicles (EVs) are cell-derived membranous vesicles that exist in nearly all biological

279 that nucleate and grow inside intracellular membranous vesicles that originate from invaginations of

280 nus, are released from cells nonlytically in membranous vesicles.

281 t the dsRNA is present in nuclease-resistant membranous VRCs.

282 and 10 that influence the susceptibility to membranous VSDs in Nkx2-5(+/-) animals.

283 o double-membrane structures by extension of membranous walls and/or collapsing of the luminal cavity

284 solic membrane vesicles often clustered in a membranous web (MW).

285 These drugs target de novo formation of the membranous web and RNA replication.

286 block replication of HCV RNA at the stage of membranous web biogenesis-a new paradigm in antiviral th

287 also analyzed the effects of cyclosporine on membranous web formation by electron microscopy.

288 OSBP was required for HCV replication and membranous web integrity.

289 patitis C virus (HCV) genome, presumably via membranous web shaping, and assembly of new virions, lik

290 patitis C virus (HCV) genome, presumably via membranous web shaping, and assembly of new virions, lik

291 Daclatasvir inhibits the formation of new membranous web structures and, ultimately, of replicatio

292 yclosporine blocked de novo formation of the membranous web, but had little effect on established mem

293 he HCV replication compartment, known as the membranous web, is believed to be cholesterol enriched,

294 evealed that 25HC inhibited formation of the membranous web, the HCV replication factory, independent

295 sitol-4 kinase IIIalpha and induction of the membranous web, which is the site of HCV replication.

296 V replication by preventing formation of the membranous web, which was not linked to an inhibition of

297 , but completely prevented biogenesis of the membranous web.

298 integrity and cholesterol enrichment of the membranous web.

299 OSBP was recruited to membranous webs in a PI 4-kinase-dependent manner, and b

300 he seagrass genus Posidonia are covered by a membranous wing that we hypothesize plays a fundamental