ライフサイエンスコーパス: menaquinone

1 low-level maintenance of the mono-saturated menaquinone.

2 MenA, an enzyme involved in the synthesis of menaquinone.

3 they are likely to affect the redox state of menaquinone.

4 nisms they employ for succinate oxidation by menaquinone.

5 gene that is involved in the biosynthesis of menaquinone.

6 ts ability to synthesize both ubiquinone and menaquinone.

7 formation of the respiratory chain component menaquinone.

8 nsfers reducing equivalents to ubiquinone or menaquinone.

9 genation of the respiratory electron carrier menaquinone.

10 ion of ferredoxin and exergonic reduction of menaquinone.

11 s in response to the accumulation of reduced menaquinone.

12 transfer pathway for succinate oxidation by menaquinone.

13 be complemented by the addition of exogenous menaquinone.

14 t that CMTn-1 was also markedly deficient in menaquinones.

15 h results in the synthesis and absorption of menaquinones.

16 t the dimer interface that contain two bound menaquinones.

17 in K occurs in the diet as phylloquinone and menaquinones.

18 heptose biosynthesis in adenoma and elevated menaquinone-10 biosynthesis in CRC.

19 Menaquinone-2 (MK-2), a truncated MK, was synthesized, a

20 ation by LC-ESI-MS/MS of phylloquinone (PK), menaquinone-4 (MK-4), menaquinone-7 (MK-7) and menaquino

21 GGpp) to synthesize the vitamin K(2) subtype menaquinone-4 (MK-4).

22 1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4).

23 vert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) and store the latter in tissu

24 Here, we show that UBIAD1, a vitamin K2/menaquinone-4 biosynthetic enzyme, functions cell-autono

25 issues in its original form and converted to menaquinone-4 or whether it is converted to menadione in

26 Tocotrienol and menaquinone-4 were produced in vte5-2 folk plants after

27 re the novel finding that vitamin K1 and K2 (menaquinone-4) potently inhibit glutathione depletion-me

28 GGpp) to synthesize the vitamin K(2) subtype menaquinone-4.

29 l phylloquinone and a major source of tissue menaquinone-4.

30 into tissues but is not converted further to menaquinone-4.

31 ione to tissues and subsequent conversion to menaquinone-4.

32 metry analysis of the quinone extract showed menaquinone-6 as the major component.

33 of phylloquinone (PK), menaquinone-4 (MK-4), menaquinone-7 (MK-7) and menaquinone-9 (MK-9) was develo

34 3-409) have recently analyzed the content of menaquinone-7 (MK-7) in eight dietary supplements.

35 men with type 2 diabetes and CVD to 360 ug/d menaquinone-7 (MK-7) or placebo for 6 mo.

36 Menaquinone-7 (MK-7), also known as vitamin K2, is a cof

37 APP) achieves significant incorporation into menaquinone-7 (MK-7), regardless of inhibition of endoge

38 shown that the pure enzyme contains 1 eq of menaquinone-7 and that the enzyme stabilizes a mena-semi

39 some of these products contain a mixture of menaquinone-7 geometric isomers.

40 first time, the cis/trans isomer content of menaquinone-7 in food products has been identified and m

41 trochemistry, it is shown that vesicle-bound menaquinone-7 is not only a substrate for this enzyme bu

42 chromatographic method for the separation of menaquinone-7 isomers and an nuclear magnetic resonance

43 favorable complexes between the cis or trans menaquinone-7 isomers and the silver cation.

44 Dihydrogenated menaquinone-8 [menaquinone-8(H(2))], which probably acts

45 econstituted with excess of ubiquinone-8 and menaquinone-8 analogues.

46 Dihydrogenated menaquinone-8 [menaquinone-8(H(2))], which probably acts as a quencher

47 naquinone-4 (MK-4), menaquinone-7 (MK-7) and menaquinone-9 (MK-9) was developed, and single-laborator

48 sociated stalk, which transports and reduces menaquinone 94 angstrom from the membrane.

49 Electron transfer to the menaquinone acceptor on the opposite side of the membran

50 of the biologically available ubiquinone and menaquinone aid in driving the chemical reaction in one

51 [4Fe-4S] clusters, two heme b groups, and a menaquinone analog.

52 n to the reduction of various ubiquinone and menaquinone analogues.

53 ovide further evidence for the importance of menaquinone and aerobic metabolism for L. monocytogenes

54 urified R48H exhibits very low activity with menaquinone and an apparent Michaelis constant (K(m)) fo

55 Mutants in ubiquinone synthesis (but not menaquinone and demethylmenaquinone) and cytochrome bd-I

56 tase activity, resulting in net oxidation of menaquinone and inhibition of Cu(II) reduction, response

57 erring electrons to a membrane-bound pool of menaquinone and multiple oxidases transferring electrons

58 renoid intermediate in the synthesis of both menaquinone and the sesquarterpenoids.

59 droxybenzoic acid (ubiquinone biosynthesis), menaquinone, and aromatic amino acids.

60 e required for the synthesis of both CoQ and menaquinone, and it is the 5' gene in an operon containi

61 ion-translocating electron transfer complex, menaquinone, and membrane-bound Fe-S proteins with assoc

62 major fatty acids, MK-12 as the predominant menaquinone, and ornithine as the diagnostic diamino aci

63 er important metabolites, including folates, menaquinone, and siderophores.

64 y of both enzymes, their copurification with menaquinone, and the distinctive detection of a protein-

65 nfounders, dietary intakes of phylloquinone, menaquinones, and total vitamin K, assessed with either

66 These results indicate that menaquinones are essential components for the reduction

67 ssential subunit mediates the utilization of menaquinone as an electron acceptor as shown by the form

68 to Mtb drug treatment shifted the menaquinol/menaquinone balance toward a reduced state that stimulat

69 The structure of the menaquinone binding site could provide a framework for t

70 Triton X-100 and oxygen affect the menaquinone binding site, but n-dodecyl beta-D-maltoside

71 teracts with its partner, the membrane-bound menaquinone-binding protein CoxG.

72 the o-succinylbenzoate synthase reaction in menaquinone biosynthesis (kcat/Km = 2.5 x 10(5) and 7.5

73 ew compounds also target enzymes involved in menaquinone biosynthesis and electron transport, inhibit

74 he ubiE homolog is likely to be required for menaquinone biosynthesis and is located within the gerC

75 Small colony variants specifically lacking menaquinone biosynthesis arose after prolonged Spm expos

76 al targets, which included interference with menaquinone biosynthesis by inhibiting demethylmenaquino

77 OSBS reaction; intriguingly, the operon for menaquinone biosynthesis in G. kaustophilus does not enc

78 efore represent a good target for disrupting menaquinone biosynthesis in M. tuberculosis.

79 The first committed step in menaquinone biosynthesis is catalyzed by MenD, a thiamin

80 Menaquinone biosynthesis is initiated by the conversion

81 first evidence of feedback regulation of the menaquinone biosynthesis pathway in bacteria, identifyin

82 ow that the last cytosolic metabolite in the menaquinone biosynthesis pathway, 1,4-dihydroxy-2-naphth

83 hin biosynthesis, SCVs defective for heme or menaquinone biosynthesis were significantly more resista

84 AAE14 was able to restore menaquinone biosynthesis when expressed in an Escherichi

85 H. pylori uses an unusual pathway for menaquinone biosynthesis with 5'-methylthioadenosine/S-a

86 ic carbon metabolism, membrane transporters, menaquinone biosynthesis, and complexes I-IV of the euba

87 s independently confirmed the restoration of menaquinone biosynthesis, and similarly, analyses of iso

88 We first depleted MenG, a key enzyme in the menaquinone biosynthesis, by CRISPRi and observed that t

89 sport, amino acid metabolism, ubiquinone and menaquinone biosynthesis, cell surface adhesion, biosynt

90 roxy-2-naphthoate (DHNA), an intermediate of menaquinone biosynthesis, is essential for cytosolic sur

91 al pathways, autoinducer-2 biosynthesis, and menaquinone biosynthesis.

92 , and also defective in either ubiquinone or menaquinone biosynthesis.

93 methylation reactions in both ubiquinone and menaquinone biosynthesis.

94 CoA to form OSB-CoA, the fourth step of the menaquinone biosynthetic pathway in Bacillus anthracis.

95 omparison with genes encoding enzymes of the menaquinone biosynthetic pathway in Escherichia coli.

96 zes an exergonic dehydration reaction in the menaquinone biosynthetic pathway in which 2-succinyl-6-h

97 efforts targeting the MenG enzyme within the menaquinone biosynthetic pathway, we have pursued the op

98 obutyrate (o-succinylbenzoate or OSB) in the menaquinone biosynthetic pathway.

99 qnE) is a radical SAM enzyme involved in the menaquinone biosynthetic pathway.

100 losine in the second step of the alternative menaquinone biosynthetic pathway.

101 for a C-methyltransferase step in the Q and menaquinone biosynthetic pathways in Escherichia coli.

102 ll surface structures, while ubiquinones and menaquinones, both containing an essential prenyl moiety

103 synthetic pathway leading from chorismate to menaquinone, catalyzes the conversion of O-succinylbenzo

104 etermined.This study aimed to quantify fecal menaquinone concentrations and identify associations bet

105 ions and identify associations between fecal menaquinone concentrations and serum vitamin K concentra

106 s associated with any marker of inflammation.Menaquinone concentrations in the human gut appear highl

107 owever, interindividual variability in fecal menaquinone concentrations partitioned individuals into

108 omposition, and inflammation.Fecal and serum menaquinone concentrations, fecal microbiota composition

109 lloquinone and dihydrophylloquinone, but not menaquinones, confer a lower risk of pancreatic cancer.

110 MOs as key players of B-oxidation in (methyl)menaquinone-containing organisms.

111 These menaquinones contribute to vitamin K nutriture during di

112 obacterial cytochrome bc1 :aa3 consists of a menaquinone:cytochrome c reductase (bc1 ) and a cytochro

113 The menaquinone:cytochrome c reductase, or bc complex, of Ba

114 es with the function of the subunit b of the menaquinone:cytochrome c reductase.

115 e total median (IQR) fecal concentrations of menaquinones decreased in the WG diet compared with the

116 rowth with glycerol and fumarate, Hyd-2 used menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydro

117 m the bacterium Megasphaera elsdenii and the menaquinone-dependent NADH:ferredoxin oxidoreductase fro

118 ones, such as menaquinone (MK), and dimethyl-menaquinone (DMK).

119 Remarkably, the barriers to diffusive menaquinone dynamics are lesser than that of the more ub

120 this reaction to the exergonic reduction of menaquinone (E ' -80 mV).

121 inds of quinones (ubiquinone for aerobic and menaquinone for anaerobic growth) in the electron-transp

122 nding interactions with the pocket, favoring menaquinone for charge transport in T. thermophilus.

123 I: 0.41, 0.85; P for trend = 0.006), but not menaquinones (for quartile 4 vs. quartile 1, HR = 0.93;

124 at the affinity of the quinone, specifically menaquinone, for the binding-site is higher than that of

125 identified genera were associated with >/=1 menaquinone form.

126 l differences in concentrations of different menaquinone forms rather than the diet group or the time

127 mperatures produce only all-trans isomers of menaquinones from MK-5 (menaquinone with five isoprenyl

128 ntrations of individual menaquinones nor the menaquinone group was associated with any marker of infl

129 e futalosine pathway toward the synthesis of menaquinone in Chlamydiaceae.

130 r data indicate weaker hydrogen bonds of the menaquinone in cytochrome aa(3)-600 in comparison with u

131 Since utilization of menaquinone in the electron transport system is a charac

132 Thus, NR appears to replace the function of menaquinone in the fumarate reductase complex, and it en

133 is therefore not dependent on the levels of menaquinone in these cells.

134 2 and 8.The median total daily excretion of menaquinones in feces was 850 nmol/d but was highly vari

135 bacterially derived vitamin K forms known as menaquinones in health and disease, which may be attribu

136 The ubiquity of saturated menaquinones in the Archaea in comparison to Bacteria su

137 udies have shown that both phylloquinone and menaquinone intake might reduce cardiovascular disease (

138 tol-dependent reduction of phylloquinone and menaquinone into their respective quinol forms.

139 A key reaction in the biosynthesis of menaquinone involves the conversion of the soluble bicyc

140 ved in the aerobic assimilation of iron, and menaquinone is involved in anaerobic electron transport,

141 Vitamin K (as phylloquinone and menaquinones) is an essential cofactor for the conversio

142 response to the reduced state of respiratory menaquinones, is a positive regulator of nos expression.

143 nts were no less susceptible to Spm implying menaquinone itself rather than general respiration is re

144 Reduced endogenous menaquinone levels along with enhanced levels of extrace

145 Although menaquinone levels are known to be tightly linked to the

146 While MR1-CYMA retained menaquinone levels comparable to those of MR-1, it lost

147 lling studies and quantification of cellular menaquinone levels suggested that menaquinone synthesis,

148 This report demonstrates that the depressed menaquinone levels were the result of the rifampin resis

149 ein-level regulatory mechanism that controls menaquinone levels within the cell and may therefore rep

150 of rifampin resistance leading to decreased menaquinone levels, indicating that rifampin-resistant s

151 , we demonstrate that borinic esters inhibit menaquinone methyltransferase in gram positive bacteria

152 We measured phylloquinone (PK) and menaquinone (MK) -4 to -10 in cheese, yoghurt and meat p

153 esis of both the respiratory chain component menaquinone (MK) and the siderophore 2,3-dihydroxybenzoa

154 Menaquinone (MK) biosynthesis pathway is a potential tar

155 ts identified in this screen inactivated the menaquinone (MK) biosynthesis pathway.

156 Menaquinone (MK) or vitamin K(2) is an important metabol

157 tively, i.e., close to the Em,7 value of the menaquinone (MK) pool, indicating a collisional interact

158 cillus subtilis, produce homologs other than menaquinone (MK) with seven isoprene units.

159 ubiquinone (UQ) and naphthoquinones, such as menaquinone (MK), and dimethyl-menaquinone (DMK).

160 nts for these genes had decreased amounts of menaquinone (MK), increased resistance to killing, and a

161 Directly targeting menaquinone (MK), which plays an important role in bacte

162 he genes to produce vitamin K in the form of menaquinone (MK).

163 Menaquinone (MK, vitamin K2) is a lipid-soluble molecule

164 Menaquinone (MK-4) supplementation rescued MRSA growth,

165 or quantification of phylloquinone (PK), and menaquinones (MK) 4-10 in food using deuterium labelled

166 vitamin K compounds: phylloquinone (PK) and menaquinones (MK-n).

167 tamin K1 (phylloquinone; PK) and vitamin K2 (menaquinones; MK-4 to MK-10) in 88 composite food sample

168 mes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme.

169 monas viridis [containing ubiquinone (UQ) or menaquinone (MQ) at QA site, respectively].

170 We identify that both ubiquinone (UQ) and menaquinone (MQ) can form stacking and hydrogen-bonded i

171 weight-cytochrome c3) complex-linked reverse menaquinone (MQ) redox loop become increasingly importan

172 cation process (electron confurcation) and a menaquinone (MQ) redox loop-mediated reverse electron fl

173 h both natural quinones, ubiquinone (UQ) and menaquinone (MQ), at a single quinone binding site.

174 In a menaquinone (MQ)-based electron confurcation reaction, t

175 Menaquinones (naphthoquinones, MK) are isoprenoids that

176 d neither fecal concentrations of individual menaquinones nor the menaquinone group was associated wi

177 There was little effect of menaquinone on growth inhibition by SQ109, but there wer

178 the first committed step for biosynthesis of menaquinone, or vitamin K2, a key cofactor for electron

179 piratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberc

180 Type-II NADH-menaquinone oxidoreductase (NDH-2) is an essential respi

181 The electron-transferring flavoprotein-menaquinone oxidoreductase ABCX (EtfABCX), also known as

182 nothiazine analogs specifically inhibit NADH:menaquinone oxidoreductase activity.

183 th chains can be initiated with type II NADH:menaquinone oxidoreductase.

184 und FeS oxidoreductase functioning as an ETF:menaquinone oxidoreductase.

185 Diheme-containing succinate:menaquinone oxidoreductases (Sdh) are widespread in Gram

186 Helicobacter pylori uses MTAN in its unusual menaquinone pathway, making H. pylori MTAN a target for

187 host of uncommon functionalities including a menaquinone pathway-derived 2-naphthoate moiety, 4-methy

188 tty acids, as well as in the biosynthesis of menaquinone, peptide antibiotics, and peptide siderophor

189 ked to the aerobic respiratory chain via the menaquinone pool and are differentially affected by resp

190 ether, these data demonstrate that a reduced menaquinone pool directly or indirectly triggers inducti

191 enaquinone was added, demonstrating that the menaquinone pool is a limiting factor in regulon inducti

192 The menaquinone pool is central to the electron transport sy

193 enaquinone pool or decreased the size of the menaquinone pool itself.

194 mpounds that occluded electron flow into the menaquinone pool or decreased the size of the menaquinon

195 rons from periplasmic cytochrome c(3) to the menaquinone pool.

196 However, the relevance of menaquinones produced by gut bacteria to vitamin K requi

197 adenine dinucleotide cofactor, blocking the menaquinone-reducing site.

198 The menaquinone reduction site associated with a possible pr

199 During growth, the wild type releases a menaquinone-related redox-active small molecule into the

200 plementation of growth medium with exogenous menaquinone rescued both growth and oxygen consumption o

201 Under truly anaerobic conditions, menaquinone shuttles electrons to alternate final electr

202 The MST enzymes (menaquinone, siderophore, and tryptophan biosynthetic en

203 hesis of pantothenate, coenzyme A, thiamine, menaquinone, siderophores/metallophores, and bacillithio

204 DhbC is also 35% identical to the Bs menaquinone-specific isochorismate synthase, MenF, illus

205 rismate, a reaction that is catalyzed by the menaquinone-specific isochorismate synthase, MenF.

206 The aim of this study was to assess if menaquinone supplementation, compared to placebo, decrea

207 signaling via DosS and rescue inhibition of menaquinone synthesis and is less toxic.

208 chorismate synthase specifically involved in menaquinone synthesis encoded by the menF gene.

209 Mutations that eliminated menaquinone synthesis eradicated the superoxide formatio

210 ase (OSBS) family, which catalyzes a step in menaquinone synthesis in diverse microorganisms and plan

211 nes menE-menC-MW1733-ytkD-MW1731 involved in menaquinone synthesis in the major human pathogen Staphy

212 tive to the MenA inhibitors, indicating that menaquinone synthesis is a valid new drug target in Gram

213 Menaquinone synthesis provides another target for agents

214 MTANs are involved in quorum sensing, menaquinone synthesis, and 5'-methylthioadenosine recycl

215 f cellular menaquinone levels suggested that menaquinone synthesis, and consequently electron transpo

216 ylhydrolase (HpMTAN) proposed to function in menaquinone synthesis.

217 owth on succinate and in both ubiquinone and menaquinone synthesis.

218 an outward-facing formate dehydrogenase via menaquinones to a fumarate reductase located at the cyto

219 ron acceptor, electrons are transferred from menaquinones to outward-facing CprA, via an as-yet-unide

220 normally and synthesize wild-type levels of menaquinone under anaerobic conditions in iron-sufficien

221 Biochemical analysis of menaquinones upon entry into hypoxic/anaerobic condition

222 , synthesized and evaluated against MRSA and menaquinone utilizing bacteria in aerobic conditions.

223 the first report of a Rieske protein from a menaquinone-utilizing organism.

224 yzes the initial step in the biosynthesis of menaquinone via the futalosine pathway.

225 step in the classical biosynthetic route to menaquinone (vitamin K(2)) is a Stetter-like conjugate a

226 Menaquinone (vitamin K(2)) plays a vital role in energy

227 s deficiency was overcome by the addition of menaquinone (vitamin K(2)).

228 is a key intermediate in the biosynthesis of menaquinone (vitamin K2) in both gram-negative and gram-

229 li, the biosynthesis of the electron carrier menaquinone (vitamin K2) involves at least seven identif

230 first committed step in the biosynthesis of menaquinone (vitamin K2) is the conversion of chorismate

231 Bacterial enzymes of the menaquinone (Vitamin K2) pathway are potential drug targ

232 biosynthesis of ubiquinone (coenzyme Q) and menaquinone (vitamin K2), essential isoprenoid quinone c

233 ynthesis of the siderophore enterobactin and menaquinone (vitamin K2).

234 etary intake of phylloquinone (vitamin K-1), menaquinones (vitamin K-2), and total vitamin K with the

235 Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-

236 etary intakes of phylloquinone (vitamin K1), menaquinones (vitamin K2), and dihydrophylloquinone (dih

237 n during hypoxia was observed when exogenous menaquinone was added, demonstrating that the menaquinon

238 Menaquinones were not detected in serum, and neither fec

239 le to reduce Fe(III) in the absence of added menaquinone when formate was used as the electron donor.

240 The structure also shows menaquinone, which is preferentially used over ubiquinon

241 esis that this bacterial overgrowth produces menaquinones, which would meet the vitamin requirement i

242 Mtbd was shown to be specific for menaquinone, while regulation by reduction of the Q-loop

243 all-trans isomers of menaquinones from MK-5 (menaquinone with five isoprenyl units) to MK-15 (fifteen

244 It reduces both ubiquinones and menaquinones with similar efficiencies and preferably us

245 Saturated and monounsaturated menaquinones with six isoprenoid units forming the alkyl