ライフサイエンスコーパス: meniscal

1 The presence of meniscal and ACL tears was associated with more rapid ca

2 Meniscal and articular cartilage matrix calcification ar

3 ith aging-related cartilage calcification in meniscal and articular cartilages.

4 n and function were assessed preoperatively; meniscal and cartilage abnormalities were documented at

5 mine the relationships between inflammation, meniscal and cartilage pathology, and symptoms.

6 ide whether to refer patients with potential meniscal and ligament injuries, and we prefer clinical c

7 ion and magnetic resonance imaging (MRI) for meniscal and ligamentous knee damage.

8 lage lesions, bone marrow edema pattern, and meniscal and ligamentous lesions were frequently demonst

9 Meniscal and ligamentous tearing are the most frequent i

10 Baker cyst, effusion, internal derangement (meniscal and/or anterior cruciate ligament tears), media

11 , osteophytes, subchondral cysts, sclerosis, meniscal and/or ligamentous tears, joint effusion, synov

12 cal body was greater than that of the medial meniscal body (P <.05).

13 orn (P <.05), and enhancement of the lateral meniscal body was greater than that of the medial menisc

14 19.7%, P < .0001) but not in the group with meniscal but no root tear (76.7% vs 65.2%, P = .055).

15 vances in the understanding of the nature of meniscal calcification and its relationships with menisc

16 ve identified a guinea pig OA model in which meniscal calcification appears to correlate with aging a

17 Meniscal calcification correlated with cartilage degener

18 Recent findings support a pathogenic role of meniscal calcification in osteoarthritis.

19 Meniscal calcification is a new target for the developme

20 Meniscal calcification is positively associated with men

21 Meniscal calcification, similar to meniscal degeneration

22 ologic as well as quantitative evaluation of meniscal calcifications.

23 cond group of six monkeys (group 2), porcine meniscal cartilage and porcine articular cartilage plugs

24 1 expression was detectable in cultured knee meniscal cartilage cells.

25 r and a potential pathogenic factor for knee meniscal cartilage matrix calcification.

26 Upon explant, all meniscal cartilage samples in this group demonstrated hi

27 or possible human transplantation, xenograft meniscal cartilage was transplanted from pigs and cows i

28 nees, HB-IGF-1 was retained in articular and meniscal cartilage, but not in tendon, consistent with e

29 that is produced by chondrocytes within the meniscal cartilage.

30 effects of 3 PDNP-family NTPPPH isozymes on meniscal cell matrix calcification.

31 ntitative and objective metrics to assess OA meniscal cell phenotypes.

32 Meniscal cell TGase activity was stimulated by nitric ox

33 er of meniscal cells and in association with meniscal cell-derived matrix vesicles (MVs).

34 nt calcification inhibitor of osteoarthritis meniscal cell-mediated calcium deposition.

35 ondrogenic potency of avascular and vascular meniscal cells and chondrocytes from medial OA knee join

36 Only PC-1 was abundant at the perimeter of meniscal cells and in association with meniscal cell-der

37 Both endogenous meniscal cells and MSCs infiltrated the MDM scaffolds.

38 transfected the isozymes in nonadherent knee meniscal cells cultured with ascorbic acid, beta-glycero

39 We have demonstrated that meniscal cells derived from the lateral meniscus in medi

40 at a significantly higher level on avascular meniscal cells derived from tissues with a more degenera

41 Osteoarthritis meniscal cells display a distinct gene-expression profil

42 nd produce more calcium minerals than normal meniscal cells in vitro.

43 Conversely, meniscal cells in younger patients appear to respond to

44 ene expression suggest that in older adults, meniscal cells might dedifferentiate and initiate a prol

45 d that a significantly greater percentage of meniscal cells were positive for CD49b, CD49c and CD166

46 direct transfection of chondrocytic TC28 and meniscal cells, both induced matrix apatite deposition.

47 ene-expression profile different from normal meniscal cells, have elevated expression of ankylosis pr

48 CCL21 was more localized to chondrocytes and meniscal cells.

49 ification of each NTPPPH isozyme in vitro in meniscal cells.

50 monstrated in both knee menisci and cultured meniscal cells.

51 cification (with hydroxyapatite crystals) by meniscal cells.

52 Neither diet nor treatment affected the meniscal collagen content.

53 Meniscal corner tears had a PPV of 0% medially and 50% l

54 h included meniscal displacement, peripheral meniscal corner tears, increased perimeniscal signal int

55 Since meniscal coverage and meniscal height diminished with su

56 nd varus malalignment (medially) and lateral meniscal damage (laterally).

57 There was also a strong association between meniscal damage and cartilage loss.

58 everal MR features (eg, bone marrow lesions, meniscal damage and extrusion, and synovitis or effusion

59 ed and older adults, any association between meniscal damage and the development of frequent knee pai

60 we found no independent association between meniscal damage and the development of frequent knee sym

61 cted tibial and femoral loss included medial meniscal damage and varus malalignment (medially) and la

62 in seems to be present because both pain and meniscal damage are related to OA and not because of a d

63 each predictor (meniscal position factor and meniscal damage as dichotomous predictors in each model)

64 ned lateral cartilage damage and progressive meniscal damage as increases in cartilage or meniscus sc

65 n, MRI is more sensitive for ligamentous and meniscal damage but less specific.

66 paucity of data regarding the prevalence of meniscal damage in the general population and the associ

67 To evaluate the effect of meniscal damage on the development of frequent knee pain

68 Lateral meniscal damage predicted every lateral outcome.

69 After full adjustment, medial meniscal damage predicted medial tibial cartilage volume

70 h there was a modest association between the meniscal damage score (range 0-3) and the development of

71 nded to the case-control status assessed the meniscal damage using the following scale: 0 = intact, 1

72 The effect of meniscal damage was analyzed by contingency tables and l

73 Meniscal damage was common at baseline both in case knee

74 adjusted for age, sex, and body mass index), meniscal damage was mostly present in knees with OA.

75 Cartilage and meniscal damage were scored on MRI in the medial and lat

76 The aim of this study was to test whether meniscal damage, meniscal extrusion, malalignment, and l

77 d for cartilage damage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effu

78 cartilage damage, the presence of high BMI, meniscal damage, synovitis or effusion, or any severe ba

79 ation, subchondral bone (SCB) sclerosis, and meniscal damage.

80 effects, in part, by increasing the risk of meniscal damage.

81 valgus malalignment with progressive lateral meniscal damage.

82 body mass index (BMI), bone marrow lesions, meniscal damage/extrusion, synovitis, effusion, and prev

83 We show that, when placed into a meniscal defect, the controlled release of collagenase a

84 omoted the integrative repair of an in vitro meniscal defect.

85 cal calcification and its relationships with meniscal degeneration and cartilage lesions in osteoarth

86 Its effect on preventing meniscal degeneration and the molecular mechanisms under

87 to detect and quantify cartilage matrix and meniscal degeneration between normal healthy volunteers

88 dels demonstrated that meniscal position and meniscal degeneration each contributed to prediction of

89 Cartilage and meniscal degeneration were scored on MRI in the medial a

90 redictor variables were MRI cartilage score, meniscal degeneration, and meniscal position measures.

91 Meniscal calcification, similar to meniscal degeneration, is a predisposing factor for cart

92 calcification is positively associated with meniscal degeneration, which is an early event in the de

93 Cartilage and meniscal degradation in mice were measured via microCT,

94 After the 13-day Shuttle flight, meniscal degradation was observed.

95 The prevalence of a meniscal tear or of meniscal destruction in the right knee as detected on MR

96 p between synovitis and symptoms in isolated meniscal disease has not been reported.

97 Meniscal displacement (measured from the meniscal edge t

98 Meniscal displacement did not correlate with effusion.

99 f meniscocapsular separation, which included meniscal displacement, peripheral meniscal corner tears,

100 ed on our results, a strong relation between meniscal dynamics and tibiofemoral kinematics was confir

101 Meniscal displacement (measured from the meniscal edge to the tibia) was as great as 10 mm medial

102 e changes in the Lysholm and Western Ontario Meniscal Evaluation Tool (WOMET) scores (each ranging fr

103 We studied knee medial meniscal expression in situ of 3 NTPPPH isozymes of the

104 or tibiofemoral cartilage loss were baseline meniscal extrusion (adjusted OR 3.6 [95% CI 1.3-10.1]),

105 ars (adjusted OR, 3.19; 95% CI: 1.13, 9.03), meniscal extrusion (adjusted OR, 3.62; 95% CI: 1.34, 9.8

106 ication of tibio-femoral osteophytes, medial meniscal extrusion and medial femoral cartilage morpholo

107 Laxity and meniscal extrusion had inconsistent effects.

108 Meniscal extrusion is probably an effect of the complex

109 age, knee effusion, and body mass index with meniscal extrusion were assessed by using logistic regre

110 Apart from meniscal extrusion, all features of tissue abnormalities

111 femoral articular cartilage, osteophytes and meniscal extrusion, and of radiographic assessment of jo

112 nt as the meniscal tear, greater severity of meniscal extrusion, greater overall severity of joint de

113 s study was to test whether meniscal damage, meniscal extrusion, malalignment, and laxity each predic

114 amage, bone marrow lesions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to rep

115 ion between clinical outcome and severity of meniscal extrusion, total BLOK score, and meniscal tear

116 Clinical results were worse with meniscal extrusion, with complaints of locking.

117 t, and cartilage damage were associated with meniscal extrusion, with odds ratios (ORs) of 6.3 (95% c

118 t, and cartilage damage were associated with meniscal extrusion, with ORs of 10.3 (95% CI: 7.1, 14.9)

119 he effects of age, body mass index, sex, and meniscal extrusion.

120 l medial and lateral osteophytes, and medial meniscal extrusion.

121 t cartilage damage, bone marrow lesions, and meniscal extrusion.

122 ars are not the only factors associated with meniscal extrusion; other factors include knee malalignm

123 on to determine the relative contribution of meniscal factors and cartilage morphologic features to J

124 Abnormal-appearing meniscal fascicles had a PPV of 8% for lateral meniscoca

125 Meniscal fibrocartilage shows yet another V/XI phenotype

126 Incidental meniscal findings on MRI of the knee are common in the g

127 A meniscal flounce is a fold that occurs in the absence of

128 Meniscal GAG content was increased in the contralateral

129 and only three of them (7.7%) demonstrated a meniscal haemorrhage.

130 TNF mAb may be useful clinically to promote meniscal healing following injury.

131 Since meniscal coverage and meniscal height diminished with subluxation, less covera

132 ectional area (CSA) of the ligaments and the meniscal heights and widths were recorded.

133 effusions were seen in 26 (87%) of 30 knees, meniscal hypoplasia in 11 (37%) of 30 knees, and abnorma

134 ions was additionally tested for a potential meniscal implant biomaterial.

135 meniscal injuries (30%), followed by lateral meniscal injuries (21%).

136 diagnostic certainty was greatest for medial meniscal injuries (30%), followed by lateral meniscal in

137 Agreement was lowest for medial meniscal injuries (54 of 84).

138 y improved sensitivity for depicting lateral meniscal injuries (FSE, 84.6%; GRE, 75%; P = .01).

139 ynovial pathology in patients with traumatic meniscal injuries and determine the relationships betwee

140 ensional (2D) MRI for the assessment of knee meniscal injuries and to evaluate the impact of relevant

141 of three-dimensional (3D) MRI for depicting meniscal injuries of the knee by using surgery as the st

142 with 3D GRE sequences for depicting lateral meniscal injuries of the knee.

143 ere undergoing arthroscopic meniscectomy for meniscal injuries were recruited.

144 OA undergoing arthroscopic meniscectomy for meniscal injuries were recruited.

145 Significantly fewer meniscal injuries were suspected after MR imaging (P < .

146 iagnostic performance for assessment of knee meniscal injuries.

147 d (SF) from patients with early knee OA with meniscal injury could lead to inflammatory activation of

148 onstrate that sCD14 in the setting of OA and meniscal injury sensitizes FLS to respond to inflammator

149 ngs indicate that in patients with traumatic meniscal injury undergoing arthroscopic meniscectomy wit

150 In patients with traumatic meniscal injury undergoing arthroscopic meniscectomy wit

151 n, a feature of both osteoarthritis (OA) and meniscal injury, is hypothesized to be triggered in part

152 s were found in 95 (79.0%) of 120 knees, and meniscal lesions were found in 54 (45%) of 120 knees.

153 Meniscal lesions were graded by using modified subscores

154 Determination of meniscal lesions, using McMurray test, had an LR of 1.3

155 ne marrow edema pattern, and ligamentous and meniscal lesions.

156 tice of MRI evaluation and interpretation of meniscal, ligamentous, cartilaginous, and synovial disor

157 sions (OR, 4.00; 95% CI: 1.75, 9.16), medial meniscal maceration (OR, 1.84; 95% CI: 1.13, 2.99), effu

158 e medial tibiofemoral joint, each measure of meniscal malposition was associated with an increased ri

159 apping techniques assess early cartilage and meniscal matrix degeneration in osteoarthritis of the kn

160 teoglycan content in articular cartilage and meniscal matrix.

161 vere OA, which was accompanied by synovitis, meniscal mineralization, and osteophyte formation of the

162 MR imaging assessment of meniscal morphologic characteristics, meniscal position,

163 n intermediate-weighted images, (b) abnormal meniscal morphology, (c) likelihood of a typical postope

164 morphology, subchondral bone marrow lesions, meniscal morphology/extrusion, synovitis, and effusion.

165 meniscal tear without root tear, and neither meniscal nor root tear.

166 Analyses pertaining to the detection of meniscal or ligament tears and bone marrow or cartilage

167 The composite examination for specific meniscal or ligamentous injuries of the knee performed m

168 When the history suggests a potential meniscal or ligamentous injury, the physical examination

169 While most meniscal or ligamentous knee injuries heal with nonopera

170 efects of cartilage, osteophytes, sclerosis, meniscal or ligamentous tears, joint effusion, and synov

171 scal tear without root tear, and 264 without meniscal or root tear.

172 XIIIa and tTGase expression in cartilage and meniscal organ cultures.

173 Loading also led to osteophyte formation, meniscal ossification, synovial hyperplasia and fibrosis

174 , but it performs poorly in the detection of meniscal pathologies.

175 nt of synovial inflammation in patients with meniscal pathology; they also represent potential therap

176 variance explained in JSN, and the change in meniscal position accounts for a substantial proportion

177 change in medial joint space, both change in meniscal position and change in articular cartilage scor

178 he results from the models demonstrated that meniscal position and meniscal degeneration each contrib

179 used to assess the effect of each predictor (meniscal position factor and meniscal damage as dichotom

180 cartilage score, meniscal degeneration, and meniscal position measures.

181 Meniscal position was measured to the nearest millimeter

182 5 plates of each tibiofemoral joint, and the meniscal position was measured using eFilm Workstation s

183 ent of meniscal morphologic characteristics, meniscal position, and cartilage morphologic characteris

184 OA cartilage damage undergoing arthroscopic meniscal procedures.

185 All patients with meniscal repair (n = 16) needed MR arthrography to diagn

186 f 7 common elective operations (arthroscopic meniscal repair [116 749]; laparoscopic cholecystectomy

187 pair in vitro and therefore may also inhibit meniscal repair during arthritis or following joint inju

188 that IL-1Ra and TNF mAb promoted integrative meniscal repair in an inflammatory microenvironment sugg

189 concentrations of IL-1 and TNFalpha inhibit meniscal repair in vitro and therefore may also inhibit

190 All patients with meniscal repair required MR arthrography.

191 than 25% meniscal resection, and those with meniscal repair.

192 ction properties are of major importance for meniscal replacement devices, the influence of these sim

193 No patient with less than 25% meniscal resection (n = 23) needed MR arthrography to de

194 Patients with less than 25% meniscal resection did not need MR arthrography.

195 Sixteen of 61 patients with more than 25% meniscal resection needed MR arthrography to demonstrate

196 All patients with meniscal resection of more than 25%, who did not have se

197 meniscal resection, those with less than 25% meniscal resection, and those with meniscal repair.

198 into three groups: those with more than 25% meniscal resection, those with less than 25% meniscal re

199 nty-nine patients had clear MR evidence of a meniscal retear without any contrast material injected i

200 Isolated medial posterior meniscal root tear is associated with incident and progr

201 finitely improve after APM was observed if a meniscal root tear was present.

202 er overall severity of joint degeneration, a meniscal root tear, and a longer meniscal tear at preope

203 Observations on 50 meniscal samples extracted from 6 human menisci (3 later

204 d spin-echo coronal and sagittal imaging for meniscal scoring and axial and coronal spoiled gradient

205 Second-look arthroscopic confirmation of meniscal status was available in all patients.

206 ne and knee replacement (KR) associated with meniscal surgery in subjects with and those without a re

207 ubjects without a reported preceding trauma, meniscal surgery is not independently associated with in

208 Results Meniscal surgery with a history of preceding knee trauma

209 Subjects who underwent meniscal surgery with a preceding knee trauma at baselin

210 However, meniscal surgery without a history of preceding knee tra

211 Meniscal T1(rho) and T2 values correlate with clinical f

212 Correlations of meniscal T1(rho) and T2 values with age, cartilage-deriv

213 Correlations of meniscal T1(rho) and T2 values with subject age (R(2) =

214 root tear than in the group without root or meniscal tear (76.7% vs 19.7%, P < .0001) but not in the

215 A relationship with meniscal tear and degenerative joint disease independent

216 tic patients 45 years of age or older with a meniscal tear and evidence of mild-to-moderate osteoarth

217 She has undergone arthroscopic surgery for a meniscal tear and has taken nonsteroidal anti-inflammato

218 meniscectomy for symptomatic patients with a meniscal tear and knee osteoarthritis results in better

219 knee osteoarthritis (OA) and without medial meniscal tear at baseline were studied.

220 neration, a meniscal root tear, and a longer meniscal tear at preoperative MR imaging.

221 tilage damage in the root tear group and the meniscal tear group, with the no tear group serving as a

222 group and 1.84 (95% CI: 1.32, 2.58) for the meniscal tear group.

223 of meniscal extrusion, total BLOK score, and meniscal tear length.

224 Efficacy studies were conducted in a rat meniscal tear model of OA.

225 3965 potently alleviated joint pain in a rat meniscal tear model of osteoarthritis.

226 The prevalence of a meniscal tear or of meniscal destruction in the right kn

227 most always associated with a far peripheral meniscal tear or with a meniscocapsular junction injury

228 ents aged 45 to 70 years with a degenerative meniscal tear participated.

229 odel, the hazard ratio for developing medial meniscal tear was 18.2 (95% confidence interval: 8.3, 39

230 igns of osteoarthritis), the prevalence of a meniscal tear was 63% among those with knee pain, aching

231 Tear length was measured, and type of meniscal tear was classified.

232 solated medial posterior root tear, 294 with meniscal tear without root tear, and 264 without menisca

233 separated into three groups: root tear only, meniscal tear without root tear, and neither meniscal no

234 fect was used to evaluate the risk of medial meniscal tear, adjusting for age, sex, body mass index,

235 solated medial posterior root tear, 270 with meniscal tear, and 245 with no tear.

236 ificant associations (P < .01) for effusion, meniscal tear, and degenerative arthropathy, independent

237 icant associations (P < .001) with effusion, meniscal tear, and degenerative arthropathy.

238 Thirty-nine patients showed a meniscal tear, and only three of them (7.7%) demonstrate

239 marrow edema in the same compartment as the meniscal tear, greater severity of meniscal extrusion, g

240 rography to diagnose a residual or recurrent meniscal tear.

241 raphy to demonstrate a residual or recurrent meniscal tear.

242 raphy to demonstrate a residual or recurrent meniscal tear.

243 nly in the absence of other indications of a meniscal tear.

244 site on knee MR images does not represent a meniscal tear.

245 idered a risk factor for medial degenerative meniscal tear.

246 ccuracy (P = .05) for helping detect lateral meniscal tears (73.2% sensitivity and 88.4% accuracy for

247 interval [CI]: 1.01, 1.23), the presence of meniscal tears (adjusted OR, 3.19; 95% CI: 1.13, 9.03),

248 ely to have defects of cartilage (P = .001); meniscal tears (P = .001); and osteophytes, subchondral

249 medial meniscal tears (P = .04) and lateral meniscal tears (P = .01) and significantly higher accura

250 cantly higher accuracy for detecting lateral meniscal tears (P = .03) than IDEAL GRASS.

251 ntly higher sensitivity for detecting medial meniscal tears (P = .04) and lateral meniscal tears (P =

252 Four meniscal tears also demonstrated flouncelike folds.

253 ntional MR imaging at helping detect lateral meniscal tears and bone marrow edema lesions.

254 These will be discussed in reference to meniscal tears and injuries of the cruciate ligaments as

255 Among individuals with degenerative meniscal tears and OA, easily obtainable clinical inform

256 Meniscal tears and osteoarthritis (OA) frequently coexis

257 When meniscal tears are found, it is commonly assumed that th

258 Meniscal tears are not the only factors associated with

259 Meniscal tears have a poor healing capacity, and damage

260 Traumatic and degenerative meniscal tears have different anatomic features and diff

261 Traumatic and degenerative meniscal tears have different anatomic features and diff

262 Sixty-one percent of the subjects who had meniscal tears in their knees had not had any pain, achi

263 Patients who had sustained meniscal tears showed a higher average rate of progressi

264 The parameters for detecting 31 lateral meniscal tears were 58.0%, 90.6%, and 80.0% for IDEAL GR

265 espective parameters for detecting 50 medial meniscal tears were 85.0%, 91.1%, and 87.9% for IDEAL GR

266 sions, anterior cruciate ligament tears, and meniscal tears were calculated.

267 methods for detecting cartilage lesions and meniscal tears were determined.

268 ents undergoing arthroscopy for degenerative meniscal tears were recruited under Institutional Review

269 he general population and the association of meniscal tears with knee symptoms and with radiographic

270 four with flouncelike folds associated with meniscal tears) with an S-shaped fold in the free edge o

271 e ligament tears, collateral ligament tears, meniscal tears, and bone marrow edema lesions within the

272 erior and posterior cruciate ligament tears, meniscal tears, and bone marrow edema lesions, first by

273 to detect cartilage lesions, ligament tears, meniscal tears, and bone marrow edema lesions.

274 s were analyzed, including ACL tears, medial meniscal tears, and other lateral femorotibial compartme

275 d to functional knee instability, subsequent meniscal tears, and the development of early degenerativ

276 vitis in posttraumatic joint injury, such as meniscal tears, and the protective role of the pericellu

277 For meniscal tears, joint line tenderness is sensitive (75%)

278 Cross-sectional associations of severity of meniscal tears, knee malalignment, tibiofemoral cartilag

279 in clinical trials for cartilage lesions and meniscal tears, opening new avenues for cartilage and me

280 of anterior cruciate ligament tears, medial meniscal tears, or lateral meniscal tears.

281 Laterally, meniscal tears, valgus malalignment, and cartilage damag

282 Medially, meniscal tears, varus malalignment, and cartilage damage

283 lar surface and to determine the presence of meniscal tears.

284 lower sensitivity and accuracy for detecting meniscal tears.

285 als ages 45-65 years with knee pain, OA, and meniscal tears.

286 ent tears, medial meniscal tears, or lateral meniscal tears.

287 conventional SE imaging for the detection of meniscal tears.

288 for calcifications than for the surrounding meniscal tissue (P<.001).

289 to injured joints stimulates regeneration of meniscal tissue and retards the progressive destruction

290 plex inhomogeneous architecture of the human meniscal tissue at the micro and nano scale in the absen

291 ential means of examining the time course of meniscal tissue change in the development and progressio

292 l joint compartment, partially manifested by meniscal tissue mineralization.

293 In this work, we investigated human meniscal tissue structure using up-to-date non-invasive

294 he potential of MDM to integrate with native meniscal tissue to promote long-term repair without nece

295 Articular chondrocytes and meniscal tissue were also infected by FIV(HuMOR), which

296 closely associated with pain behavior in the meniscal transection model of OA.

297 nduced in male Lewis rats (n=8 per group) by meniscal transection.

298 ion, and synovial angiogenesis 35 days after meniscal transection.

299 ents (29 menisci) underwent MR imaging after meniscal transplantation.

300 discoid meniscus is the most common abnormal meniscal variant in children.