ライフサイエンスコーパス: mesenchymal progenitor

1 niofacial skeleton are derived from a common mesenchymal progenitor.

2 sts and decreased Cxcl12/SDF-1 production by mesenchymal progenitors.

3 (BMP2)-induced osteogenic differentiation of mesenchymal progenitors.

4 short-term HF progenitors, adult HFSCs, and mesenchymal progenitors.

5 velopmental processes, including the fate of mesenchymal progenitors.

6 adipocyte subtypes, and of their respective mesenchymal progenitors.

7 l system that are differentiated from common mesenchymal progenitors.

8 he osteoblast versus chondrocyte fate in the mesenchymal progenitors.

9 n elongation is fueled by recruitment of new mesenchymal progenitors.

10 PSC reprogramming and differentiation toward mesenchymal progenitors.

11 alyzing homeostasis and tissue remodeling of mesenchymal progenitors.

12 vels are reduced in Smad4-deficient limb bud mesenchymal progenitors.

13 embryos but is also expressed in multipotent mesenchymal progenitors.

14 The cardiac stroma contains multipotent mesenchymal progenitors.

15 ruption of Tsc2 in craniofacial and limb bud mesenchymal progenitors.

16 s are typically derived from tissue resident mesenchymal progenitors.

17 of patients with IPF with the properties of mesenchymal progenitors.

18 rs and functional properties consistent with mesenchymal progenitors.

19 one formation by expanding the population of mesenchymal progenitors.

20 steoblasts increased EGFR phosphorylation in mesenchymal progenitors.

21 egulate proliferation and differentiation of mesenchymal progenitors.

22 nce of CD45(-)CD34(+)CD31(-)CD13(+)CD140b(+) mesenchymal progenitors/adipose stromal cells (ASC), whi

23 iated by cellular condensation, during which mesenchymal progenitors aggregate and form 3D structures

24 We here identify Wnt5a in Osterix+ mesenchymal progenitor and stem cells (MSPCs) as a criti

25 lar chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key ce

26 ) self-renew in bone marrow niches formed by mesenchymal progenitors and endothelial cells expressing

27 d vessel assembly, endothelial cells recruit mesenchymal progenitors and induce their differentiation

28 ed phosphorylated Akt and p38MAPK amounts in mesenchymal progenitors and inhibition of these pathways

29 s transmit different signals to bone-derived mesenchymal progenitors and play critical roles in both

30 These fibrogenic mesenchymal progenitors and their progeny represent an u

31 tic states and transcriptional repression in mesenchymal progenitors and tumor cells and in preventin

32 rmed between endothelial cells and recruited mesenchymal progenitors and whether intercellular commun

33 genes involved in the fate determination of mesenchymal progenitors, and can be applied to other com

34 te repertoire derived from a distinct set of mesenchymal progenitors, and of the transcriptional regu

35 However, the identities of dental mesenchymal progenitors are largely unknown.

36 We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic than other card

37 We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic than other card

38 Various mesenchymal progenitors are reported to participate in e

39 e 4 (TBX4), and determined that TBX4-lineage mesenchymal progenitors are the predominant source of my

40 These defects are not due to eliminating mesenchymal progenitors, as neural crest cells still mig

41 promotes osteogenic lineage allocation from mesenchymal progenitors but inhibits terminal differenti

42 e associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differe

43 nchored metalloproteinase MT1-MMP (Mmp14) in mesenchymal progenitors, but not in committed osteoblast

44 e marrow normally acts to maintain a pool of mesenchymal progenitors by suppressing osteoblast differ

45 Thus, mesenchymal progenitors can be organized into localized

46 ial evidence that genetically modified human mesenchymal progenitors can slow primate aging, highligh

47 expressed CXCL12 and the cytokine SCF, were mesenchymal progenitors capable of differentiation into

48 During vertebrate development, mesenchymal progenitors capable of forming bone, cartila

49 Our results demonstrate Tsc2-deficient mesenchymal progenitors cause aberrant morphogenic signa

50 otch pathway has recently been implicated in mesenchymal progenitor cell (MPC) differentiation from b

51 to examine how cell-extrinsic forces impact mesenchymal progenitor cell (MPC) fate.

52 in a temporal and spatial fashion to control mesenchymal progenitor cell (MPC) fate.

53 As such, we developed two mesenchymal progenitor cell (MPC) lines, MPC1 and MPC2,

54 human endothelial colony forming cell (ECFC)/mesenchymal progenitor cell (MPC)-derived bioengineered

55 rate a critical role for Pod1 in controlling mesenchymal progenitor cell differentiation into SM and

56 profiling mRNA expression in the bone marrow mesenchymal progenitor cell line ST2, we discover that B

57 g these cells in vivo is challenging, making mesenchymal progenitor cell lines valuable tools to stud

58 Hedgehog signaling, has been identified as a mesenchymal progenitor cell marker in various tissues, i

59 between differentiation and maintenance of a mesenchymal progenitor cell population determines the fi

60 iversity and distinct functionality of these mesenchymal progenitor cell populations that regulate to

61 pathways and regulates proper cell fates of mesenchymal progenitor cell populations.

62 SoxC genes therefore ensure neural and mesenchymal progenitor cell survival, and function in pa

63 and direct variant to gene mapping in human mesenchymal progenitor cell-derived osteoblasts employin

64 context of chondrogenic differentiation of a mesenchymal progenitor cell.

65 ar remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes)

66 Here, we examine bone marrow-derived mesenchymal progenitor cells (BM-MPCs) that have previou

67 expression and HA production in bone marrow mesenchymal progenitor cells (bmMPCs) derived from multi

68 tated the osteogenic differentiation of bone mesenchymal progenitor cells (BMSCs).

69 ogenic young, senescent, and progeroid human mesenchymal progenitor cells (hMPCs), we delineate a hie

70 of ribosome-associated genes (RAGs) in human mesenchymal progenitor cells (hMPCs).

71 endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular network

72 exhibits accessible chromatin exclusively in mesenchymal progenitor cells (MPCs) and Ewing sarcoma ce

73 gineering platform for the delivery of human mesenchymal progenitor cells (MPCs) by a fully biologica

74 Primary mesenchymal progenitor cells (MPCs) harvested from debri

75 However, the role of TRAF3 in mesenchymal progenitor cells (MPCs) is unknown.

76 Specific knockout of miR-204/-211 in mesenchymal progenitor cells (MPCs) results in Runx2 acc

77 ifferent developmental stages and in primary mesenchymal progenitor cells (MPCs) reveals that bone ma

78 Here, we show in murine mesenchymal progenitor cells (MPCs) that Atrx deficiency

79 carring of the lung mediated by pathological mesenchymal progenitor cells (MPCs) that manifest autono

80 covered that the IPF lung harbors fibrogenic mesenchymal progenitor cells (MPCs) that serve as a cell

81 Mesenchymal progenitor cells (MPCs) transformed with the

82 characterization revealed that skin harbored mesenchymal progenitor cells (MPCs) with a similar pheno

83 ry and in peripheral neurons, we transfected mesenchymal progenitor cells (MPCs), a type of support c

84 ult mice with TRAF3 conditionally deleted in mesenchymal progenitor cells (MPCs), associated with inc

85 rentiation potential of adult tissue-derived mesenchymal progenitor cells (MPCs), such as those from

86 henotype in both human and cynomolgus monkey mesenchymal progenitor cells (MPCs).

87 (RNAseq) analysis on primary pediatric human mesenchymal progenitor cells (pMPCs) expressing EWS-FLI1

88 developing senescence (seno)-resistant human mesenchymal progenitor cells (SRCs), genetically fortifi

89 Knockdown of Pkp2 in cardiac mesenchymal progenitor cells also reduced miR-184 levels

90 al analysis of IPF lung tissue revealed that mesenchymal progenitor cells and cells with the characte

91 ater stages of differentiation can transform mesenchymal progenitor cells and generate tumors resembl

92 36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentia

93 Functionally, H3R26C-expressing mesenchymal progenitor cells and murine embryonic stem c

94 modulation regulated the differentiation of mesenchymal progenitor cells and promoted fibrocartilage

95 Wilms' tumor-1 (Wt1) leads to a reduction in mesenchymal progenitor cells and their derivatives.

96 n potential, hFOB has been compared to human mesenchymal progenitor cells and used to investigate bon

97 ing evidence that proliferating, multipotent mesenchymal progenitor cells can be programmed to yield

98 Our findings identify a population of mesenchymal progenitor cells capable of giving rise to a

99 r, identifying these cells as pivotal dental mesenchymal progenitor cells driving tooth root formatio

100 ulations, regulates lineage specification of mesenchymal progenitor cells during BMP-induced differen

101 Adult mesenchymal progenitor cells expressed CHL2, and its lev

102 appears to be derived from proliferation of mesenchymal progenitor cells followed by differentiation

103 tion factors, induces the differentiation of mesenchymal progenitor cells from the bone marrow into a

104 During organogenesis, neural and mesenchymal progenitor cells give rise to many cell line

105 ailed characterization of the most primitive mesenchymal progenitor cells in the adult murine bone ma

106 ed a significant reduction in colony-forming mesenchymal progenitor cells in the bone marrow of Apc(M

107 Dental mesenchymal progenitor cells in the dental follicle lie

108 vate scleraxis expression in a population of mesenchymal progenitor cells in the dorsal sclerotome.

109 Moreover, inactivation of beta-catenin in mesenchymal progenitor cells in vitro causes chondrocyte

110 Knockdown of miR-184 in HL-1 cells and mesenchymal progenitor cells induced and, conversely, it

111 o promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts.

112 e by coimplantation of human endothelial and mesenchymal progenitor cells isolated from blood and bon

113 is evidence for rare populations of putative mesenchymal progenitor cells located in the perivascular

114 enitors isolated from nonfibrotic lungs, IPF mesenchymal progenitor cells produce daughter cells mani

115 Removal of beta-catenin early in mesenchymal progenitor cells promoted chondrocyte differ

116 romoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes.

117 gs of patients with IPF contain pathological mesenchymal progenitor cells that are cells of origin fo

118 Postnatal bone marrow houses mesenchymal progenitor cells that are osteoblast precurs

119 ese amphibians form a "blastema", a group of mesenchymal progenitor cells that specifically directs t

120 Moreover, BMP7 triggers commitment of mesenchymal progenitor cells to a brown adipocyte lineag

121 d collaborators engineered human ESC-derived mesenchymal progenitor cells to give the ability to resi

122 formation, from their initial induction from mesenchymal progenitor cells to their terminal maturatio

123 rrow-derived MSCs (BM-MSCs) and iPSC-derived mesenchymal progenitor cells via the neural crest (NCC-M

124 ricted to the luminal aspect of the vessels; mesenchymal progenitor cells were adjacent to lumens, co

125 communicating senescent-like neutrophils and mesenchymal progenitor cells were key regulators of tiss

126 eloped a species-hybrid model in which human mesenchymal progenitor cells were used to develop white

127 In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly

128 MCs induced alkaline phosphatase activity in mesenchymal progenitor cells, and this was abrogated by

129 In murine 10T1/2 mesenchymal progenitor cells, expression of mutant IDH2

130 The perivascular environment is populated by mesenchymal progenitor cells, fibroblasts, myofibroblast

131 tation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility

132 three different cell types (C3H10T1/2 murine mesenchymal progenitor cells, primary human adipose tiss

133 Fibrocytes, which are bone marrow-derived mesenchymal progenitor cells, were increased to a greate

134 so regulates the differentiation of resident mesenchymal progenitor cells.

135 ochondrocytic differentiation of multipotent mesenchymal progenitor cells.

136 dipocytes arise from resident adipose tissue mesenchymal progenitor cells.

137 ication, but with massively dying neural and mesenchymal progenitor cells.

138 al transition and recruitment of circulating mesenchymal progenitor cells.

139 om resident adipose tissue preadipocytes and mesenchymal progenitor cells.

140 BMP-9-induced osteogenic differentiation of mesenchymal progenitor cells.

141 th the outermost tunica adventitia harboring mesenchymal progenitor cells.

142 lies on proliferation and differentiation of mesenchymal progenitor cells.

143 ing in smooth muscle cell differentiation of mesenchymal progenitor cells.

144 A-184 was predominantly expressed in cardiac mesenchymal progenitor cells.

145 d/or osteoblast differentiation of endosteal mesenchymal progenitor cells.

146 ng microRNAs in human OS cells compared with mesenchymal progenitor cells.

147 skeleton by inhibiting Hedgehog signaling in mesenchymal progenitor cells.

148 n profile of all known 27 human TRP genes in mesenchymal progenitors cells during white or brown adip

149 r developmental ancestry by Tie2-expressing (mesenchymal?) progenitor cells during development.

150 re we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cel

151 ish expressing constitutively active Akt2 in mesenchymal progenitors develop WDLPS that closely resem

152 is spatial atlas, we inferred a hierarchy of mesenchymal progenitors dictated by a more primitive cel

153 Conditional loss of Scx in mesenchymal progenitors did not affect the first stage o

154 Mesenchymal progenitors differentiate into several tissu

155 of Wnt signaling, we treated rat metanephric mesenchymal progenitors directly with recombinant Wnt pr

156 required for osteoblast differentiation from mesenchymal progenitors during endochondral bone formati

157 e bone repair by supporting inflammatory and mesenchymal progenitor egress into the zone of injury.

158 mber of the nuclear receptor superfamily, in mesenchymal progenitors favors osteoblast and myoblast d

159 The mesenchymal progenitors, fibrocytes, may be involved in

160 mice and asked whether these multipotential mesenchymal progenitors from bone marrow can adopt neura

161 Mesenchymal progenitors from Cx43-/- murine embryos and

162 A common molecular marker for all osteogenic mesenchymal progenitors has not been identified.

163 tin-green fluorescent protein (GFP)-positive mesenchymal progenitors have all been implicated in HSC

164 hese cells and investigate the role of local mesenchymal progenitors in fibrogenesis after lung trans

165 w that deleting Kindlin-2 in Prx1-expressing mesenchymal progenitors in mice causes neonatal lethalit

166 s a key molecular event that is activated in mesenchymal progenitors in response to epithelium-derive

167 ticolor reporters to characterize individual mesenchymal progenitors in the developing mouse lung.

168 d HIF-1 target gene expression and increased mesenchymal progenitors in uninjured hearts and increase

169 itogens to promote the expansion of adjacent mesenchymal progenitors, including those of the smooth m

170 skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts.

171 OPG in blocking the differentiation of early mesenchymal progenitors into RANK-expressing pre-osteocl

172 Fibrocytes are mesenchymal progenitors involved in normal and pathologi

173 The characterization of mesenchymal progenitors is central to understanding deve

174 f the fusions in hES cells differentiated to mesenchymal progenitors is compatible with prolonged via

175 dings indicate that PPR signalling in dental mesenchymal progenitors is essential for tooth root form

176 markers but positive for Pax7, Sca1, and the mesenchymal progenitor marker PDGFRalpha.

177 Thus, mesenchymal progenitors may be expanded in vitro by acti

178 When tested in noncancer mesenchymal progenitor (MePR) cells, 2 and 3 induced lit

179 As such, these mesenchymal "progenitors" might not represent the best p

180 h the growth plate, termed here "metaphyseal mesenchymal progenitors" (MMPs), are essential for cance

181 Tissue-resident mesenchymal progenitors (MPs) also participate in regene

182 the canonical Wnt pathway to be activated in mesenchymal progenitors (MPs) from cancer-induced cachec

183 scovered a unique subpopulation of polyploid mesenchymal progenitors nestled in small niches among le

184 We aimed to identify portal mesenchymal progenitors of myofibroblasts.

185 to mesenchymal transition (EMT) to form the mesenchymal progenitors of the AV valves.

186 Loss of Vhl in mesenchymal progenitors of the limb bud caused severe fi

187 ndrogenesis, we conditionally deleted VHL in mesenchymal progenitors of the limb bud, i.e. in cells n

188 We show that the cultivation of hESC-derived mesenchymal progenitors on 3D osteoconductive scaffolds

189 bone substitutes by culturing hiPSC-derived mesenchymal progenitors on osteoconductive scaffolds in

190 Integrin alpha11 deficiency in limb mesenchymal progenitors or chondrocytes reduced growth p

191 Here, we demonstrated that mesenchymal progenitor- or stromal fibroblast-specific d

192 kx2-5 and derepression of p15Ink4b in spleen mesenchymal progenitors, perturbing the cell cycle.

193 entiation, undifferentiated transitional and mesenchymal progenitor phenotypes, and mediators of cyto

194 late the activity of beta-catenin within the mesenchymal progenitor pool in mice, we investigated the

195 We also identified a heterogeneous Sox9+ mesenchymal progenitor population at the onset of palata

196 ix2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated

197 Renal vesicles are established from a mesenchymal progenitor population in response to inducti

198 c tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital re

199 phrons of the metanephric kidney form from a mesenchymal progenitor population that differentiates en

200 usly uncharacterized adipose tissue resident mesenchymal progenitor population.

201 ify 101 cell states including epithelial and mesenchymal progenitor populations and programs linked t

202 We observe a diversity of mesenchymal progenitor populations with different locati

203 Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiat

204 floxed alleles were specifically targeted to mesenchymal progenitors (Prx1Cre) or committed chondrocy

205 Conditional Il7 deletion in mesenchymal progenitors reduced B-lineage committed CLPs

206 ner medulla and described as a population of mesenchymal progenitors, released erythropoietin under h

207 Thus Gli1 marks mesenchymal progenitors responsible for both normal bone

208 iation by maintaining Shh1 responsiveness in mesenchymal progenitors (see the related article beginni

209 l pre-osteoblasts, Bmpr1b mutant bone marrow mesenchymal progenitors showed compromised differentiati

210 is an increased interest in rheumatology in mesenchymal progenitor/stem cells (MPCs) and their roles

211 ooth muscle actin-expressing macrophages and mesenchymal progenitors such as CXC chemokine ligand (CX

212 row reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the

213 ular region, including endothelial cells and mesenchymal progenitors, supports HSCs.

214 is, like other organs, maintains multipotent mesenchymal progenitors that can be potentially leverage

215 The mesenchymal progenitors that give rise to beige/brite ad

216 ells, we analyzed mutant mice lacking Vhl in mesenchymal progenitors that give rise to the soft tissu

217 ng to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper deve

218 epithelia arise de novo from fate-committed mesenchymal progenitors through a mesenchymal-to-epithel

219 ck apoptosis and regulate differentiation of mesenchymal progenitors through inhibition of glycogen s

220 During development, mesenchymal progenitors tightly regulate the balance bet

221 cells, which acts on the EGFRs expressed on mesenchymal progenitors to stimulate the Akt and p38MAPK

222 airway smooth muscle mass via recruitment of mesenchymal progenitors to the airway smooth muscle bund

223 t mechanisms: facilitating the commitment of mesenchymal progenitors to the osteoblast lineage in ass

224 gly, deletion of Cxcl12 from nestin-negative mesenchymal progenitors using Prx1-cre (Prx1 also known

225 expression and osteogenic mineralization of mesenchymal progenitors via beta-catenin.

226 Notably, mesenchymal progenitors were undetectable in the bone ma

227 kinases suppress expansion of the primitive mesenchymal progenitors, where YAP activation also preve

228 In vitro, TCF21(lin) cells are multipotent mesenchymal progenitors which form multiple somatic line

229 soluble chemotactic factors for bone marrow mesenchymal progenitors, which express a low amount of P

230 -catenin is essential in determining whether mesenchymal progenitors will become osteoblasts or chond

231 The cells functioned as mesenchymal progenitors with regard to markers and funct