ライフサイエンスコーパス: mesoderm

1 ous system, and hemocytes in the procephalic mesoderm.

2 te from the ectoderm, and hemocytes from the mesoderm.

3 Wnt in mesendoderm specification to cardiac mesoderm.

4 red ability to differentiate towards cardiac mesoderm.

5 smooth muscle is the default fate of Flk1(+) mesoderm.

6 itors for the lateral plate and intermediate mesoderm.

7 ritical to direct the cell fate into cardiac mesoderm.

8 e expression within definitive hematopoietic mesoderm.

9 fication of this lineage from cardiovascular mesoderm.

10 eproductive ductal systems: the intermediate mesoderm.

11 by contributing both to the spinal cord and mesoderm.

12 of ME genes that is required to form cardiac mesoderm.

13 1) in the module correlated with postcardiac mesoderm.

14 mmetrically into the left and right paraxial mesoderm.

15 Nodal and/or Fgf signaling, are specified as mesoderm.

16 e failure of the anterior extension of axial mesoderm.

17 activation and cell shape in the Drosophila mesoderm.

18 of southpaw expression in the lateral plate mesoderm.

19 we detected by analysis of the chick cranial mesoderm.

20 erm and posterior-primitive-streak hemogenic mesoderm.

21 a Cxcr4a-regulated tether of the endoderm to mesoderm.

22 ally symmetric morphogenesis of the paraxial mesoderm.

23 d along with WNT to generate proper tracheal mesoderm.

24 into lateral plate, cardiac, and presomitic mesoderm.

25 portion of neural tissue relative to nascent mesoderm.

26 and are found also in the dorsal splanchnic mesoderm accompanied by the expression of the secondary

27 in 1 (Strip1) that disrupts migration of the mesoderm after the gastrulation epithelial-to-mesenchyma

28 terior axis, and defects in the migration of mesoderm; all are associated with abnormalities in the p

29 This antagonism helps pattern the mesoderm along the dorsoventral axis, representing a cri

30 he nkx2.5(+) field of anterior lateral plate mesoderm (ALPM).

31 FLK1(+) mesoderm also contributes to smooth muscle and cardiomyo

32 y regulating cell motility in the presomitic mesoderm and by controlling specification of the paraxia

33 ct the anterior boundaries of the presomitic mesoderm and caudal progenitor pool.

34 s delaminate at the primitive streak to form mesoderm and definitive endoderm, through an epithelial-

35 ate generating embryonic and extra-embryonic mesoderm and definitive endoderm.

36 Cells from different germ layers - endoderm, mesoderm and ectoderm - can spontaneously segregate with

37 trulation and is concentrated in the lateral mesoderm and ectoderm at the neurula stage.

38 f-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire

39 s further propagated upon differentiation to mesoderm and ectoderm.

40 iating into the three germ layers: endoderm, mesoderm and ectoderm.

41 ough metabolic switching occurs during early mesoderm and endoderm differentiation, high glycolytic f

42 sis, differential anisotropic growth between mesoderm and endoderm drives diagonal folding.

43 at gastrulation, when the epiblast generates mesoderm and endoderm germ layers through epithelial-mes

44 itor markers and lower levels of markers for mesoderm and endoderm lineages.

45 Notably, cells committed to mesoderm and endoderm undergo widespread coordinated epi

46 nd ectoderm, and slower aggregation favoring mesoderm and endoderm.

47 t expresses nuclear markers in the ectoderm, mesoderm and endoderm/pharynx; and a Morphogenesis strai

48 ns to both transcriptional patterning of the mesoderm and FGF signaling for mesoderm migration.

49 of Ezh2 resulted in dorsalization of ventral mesoderm and formation of a secondary axis.

50 tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate developme

51 found disruptions in the organization of the mesoderm and its derivatives, including a complete failu

52 t embryonic origins of these structures from mesoderm and neural crest, respectively.

53 tor types (neuromesodermal, lateral/paraxial mesoderm and notochord progenitors; NMPs, LPMPs and Noto

54 constrictions that drive the invagination of mesoderm and posterior gut primordia.

55 hat reflect mid-primitive-streak cardiogenic mesoderm and posterior-primitive-streak hemogenic mesode

56 p, they spontaneously initiate expression of mesoderm and primordial germ cell markers asymmetrically

57 c patterns of gene expression for markers of mesoderm and primordial germ cell precursors, and format

58 1), and myogenic factor 5 (Myf5)-in paraxial mesoderm and skeletal myogenesis.

59 we investigated the role of the key paraxial mesoderm and skeletal myogenic commitment factors-mesoge

60 minant role of Ras signaling in the visceral mesoderm and that, accordingly, Ras signaling is not req

61 ly separated germ layers, namely the somitic mesoderm and the endoderm, in quail embryos.

62 ing as the gatekeeper between the presomitic mesoderm and the myogenic lineage.

63 o different tissues, namely the lateral head mesoderm and the prechordal mesendoderm, gradually induc

64 use mesoderm causes loss of Tbx4(+) tracheal mesoderm and tracheal cartilage agenesis.

65 ent KDR(+)CD235a(-) definitive hematopoietic mesoderm and WNT-independent KDR(+)CD235a(+) primitive h

66 m layer lineages: thyroid (endoderm), heart (mesoderm), and brain (ectoderm).

67 vg1 fail to form endoderm and head and trunk mesoderm, and closely resemble nodal loss-of-function mu

68 to homogenous subpopulations of endoderm and mesoderm, and comparative analysis of these gastruloids,

69 s: pluripotent stem cells, mesoderm, cardiac mesoderm, and differentiated cardiomyocytes.

70 ion experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any

71 from the hindbrain, DAN is expressed in the mesoderm, and then it becomes absent along cell migrator

72 mammalian trachea are derived from tracheal mesoderm, and tracheal malformations result in serious r

73 mber and size, restriction of the presomitic mesoderm anterior border, somite chevron morphology and

74 on, although we understand little of how the mesoderm arose.

75 s of expression in the forming lateral plate mesoderm, as demonstrated by functional perturbations du

76 ryos depleted of both notch2 and notch3 lost mesoderm- as well as neural crest-derived pdgfrb (high)

77 genitors present in anterior pharyngeal arch mesoderm at mid-gestation.

78 reshadow the coordinated invagination of the mesoderm at the onset of gastrulation.

79 6 expression is concentrated in the endoderm/mesoderm beginning at mid-blastula stage.

80 signaling interactions between endoderm and mesoderm, but how these signals are interpreted in the g

81 hare a common origin in the cardiopharyngeal mesoderm, but the chromatin landscapes that govern multi

82 , a RIPPLY family member that induces dorsal mesoderm by releasing repressive polycomb group proteins

83 the gliogenic potential of Glide/Gcm in the mesoderm by repressing the expression of the homeodomain

84 are specified from FLK1-expressing (FLK1(+)) mesoderm by the transcription factor ETV2.

85 ECs derived from cardiogenic and hemogenic mesoderm can be matured into >90% CD31(+)/VE-cadherin(+)

86 C lines at 4 stages: pluripotent stem cells, mesoderm, cardiac mesoderm, and differentiated cardiomyo

87 Loss of beta-catenin in fetal mouse mesoderm causes loss of Tbx4(+) tracheal mesoderm and tr

88 oordinates gene regulatory changes directing mesoderm cell fate decisions, which lead to the differen

89 is known about the mechanisms that regulate mesoderm cell migration in vivo.

90 row, whereby approximately 1,000 presumptive mesoderm cells exhibit coordinated apical constrictions

91 Wild-type mesoderm cells have long polarized filopodia-like protru

92 drous but directional, while extra-embryonic mesoderm cells showed little net displacement.

93 Other mesoderm cells, known as blastocoelar cells (BCs), have

94 ) domain splits in 2, separated by a mass of mesoderm cells.

95 umetric analysis of individual and groups of mesoderm cells.

96 It is thought that coordinate mesoderm constriction depends on high levels of myosin a

97 eral plate mesoderm (LPM) generates tracheal mesoderm containing chondrocytes and smooth muscle cells

98 uscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among str

99 In Drosophila embryos, caudal visceral mesoderm (CVM) cells undergo bilateral migration along t

100 4/Fgf8 double-mutants recapitulated anterior mesoderm defects and Hh-dependent GLI transcription fact

101 nstrate that partial direct reprogramming of mesoderm-derived cardiomyocytes into neurons is feasible

102 gene for DiGeorge syndrome, is expressed in mesoderm-derived chondrocytes and plays an essential and

103 C. elegans mutants in which the presumptive mesoderm-derived I4 neuron adopts a muscle-like cell fat

104 two different germ layers; the lateral plate mesoderm-derived mesenchyme and ectoderm-derived surface

105 In conclusion, the mesoderm-derived paracrine signals promote hepatocyte ma

106 lvic junction were derived from intermediate mesoderm-derived renal progenitors and were distinct fro

107 ve Hedgehog signaling in murine intermediate mesoderm-derived renal progenitors results in hydronephr

108 This suture can develop entirely within mesoderm-derived tissue, neural crest-derived tissue, or

109 lly described to come from the lateral plate mesoderm despite experimental evidence for a broader sou

110 ion timing of Hox genes in the lateral plate mesoderm determines limb placement as well.

111 ) and osteopontin expression and died during mesoderm development akin to FAK kinase-dead mice.

112 the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification;

113 trulation, as demonstrated by the absence of mesoderm development at E7.5.

114 lix-loop-helix family, play crucial roles in mesoderm development in all animals.

115 facilitate both basic and applied studies of mesoderm development.

116 T-box gene family, is a key gene in chordate mesoderm development.

117 d Wnt-signaling gene expression, and reduced mesoderm development.

118 ical Wnt signaling pathway in processes like mesoderm differentiation and tissue stiffness during tum

119 mal compartment, genes regulating presomitic mesoderm differentiation are downregulated in Sall4 muta

120 ly to the mesodermal region, suggesting that mesoderm differentiation is controlled dynamically by th

121 yment invokes Tbx6, a T-box factor, to drive mesoderm differentiation of NMPs.

122 durations of WNT and NODAL signaling control mesoderm differentiation, while the duration of BMP sign

123 erm and higher Wnt signals induce presomitic mesoderm differentiation.

124 VEGFR2+) progenitor cells in cardiac mesoderm, distinct from vascular endothelium.

125 -) chimeric embryos display defects in early mesoderm diversification, and we thus demonstrate how co

126 Transcriptional profiling of Hh-deficient mesoderm during gastrulation revealed disruptions to bot

127 convergent extension movements of the trunk mesoderm during gastrulation.

128 ould require transdifferentiation across the mesoderm-ectoderm barrier.

129 expression of a membrane reporter in nascent mesoderm enabled recording cell shape and trajectory thr

130 scriptionally similar to epiblast, ectoderm, mesoderm, endoderm, primordial germ cells, trophectoderm

131 Analysis of cultured mesoderm explants and mouse embryonic fibroblasts from n

132 endoderm begins to express Nkx2.1, and then mesoderm expresses the Tbx4 gene.

133 rmally thick mesoderm layer; later, paraxial mesoderm fails to organize into somites.

134 tion of Tbx6 as a bistable switch that turns mesoderm fate 'on' and progenitor state 'off', and thus

135 nstream of WNT to refine the endoderm versus mesoderm fate choice.

136 by controlling specification of the paraxial mesoderm fate in the tail bud.

137 s new in vivo evidence for MBK-2 function in mesoderm fate specification and LET-381 function in elon

138 s representing a transient cell state in the mesoderm-fated NMP lineage.

139 potent progenitors located in the pharyngeal mesoderm form cardiomyocytes and branchiomeric head musc

140 errant DS development during early stages of mesoderm formation and its possible connection to lower

141 ling, Rspo2 acts as an FGF antagonist during mesoderm formation and patterning.

142 TGFbeta member Vg1 is implicated in mesoderm formation but the role of the zebrafish ortholo

143 ngs reveal that cell cycle regulators direct mesoderm formation by controlling the activity of key de

144 patterning of cardiovascular spheroids after mesoderm formation from hPSCs.

145 astoma protein), are necessary for efficient mesoderm formation in a context-dependent manner.

146 h necessary and sufficient to direct cardiac mesoderm formation in frog embryos and human embryonic s

147 anscription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which

148 Ezh2 promotes Stat3 activation in ventral mesoderm formation independently of epigenetic regulatio

149 g activity specifically during lateral plate mesoderm formation while reducing fibroblast growth fact

150 Tbx transcription factors to promote dorsal mesoderm formation, but their role in myogenesis has bee

151 by repressing two inhibitors of cardiogenic mesoderm formation-Tcf3 and Foxa2-and activating inducer

152 lls to investigate the role of cell cycle in mesoderm formation.

153 blocking a direct route to embryonic cardiac mesoderm formation.

154 rease before gastrulation and induce ventral mesoderm formation.

155 niche-establishing factor Brachyury to allow mesoderm formation.

156 Skeletal muscle derives from dorsal mesoderm formed during vertebrate gastrulation.

157 4d and demonstrate that embryonic segmental mesoderm forms via teloblastic divisions, as in clitella

158 bryonic mesoderm, which is supplemented with mesoderm from the gastrulating embryo.

159 to be critical for the formation of FLK1(+) mesoderm, from which the hemangiogenic fate is specified

160 tween the zebrafish neural tube and paraxial mesoderm function as optimally engineered adhesive lap j

161 owever, the developmental process of FLK1(+) mesoderm generation and its allocation to various cell f

162 nd/or maintenance of key regulatory endoderm/mesoderm genes and is essential for gastrulation.

163 e conserved "kernel" of the bilaterian heart mesoderm GRN is operational in N. vectensis, which reinf

164 lly-fated progeny of 4d (germline, segmental mesoderm, growth zone) display significantly different c

165 obtain and identify, via CD235a expression, mesoderm harboring exclusively primitive or definitive h

166 rosophila inflated are direct targets of the mesoderm...' has been corrected online; see accompanying

167 of hematopoietic differentiation, including mesoderm, hemogenic endothelium (HE), and multipotent he

168 d acts in the marginal zone to contribute to mesoderm heterogeneity via an FGF receptor-dependent pos

169 hin definitive hematopoietic KDR(+)CD235a(-) mesoderm in a WNT- and fibroblast growth factor-dependen

170 ntribute to the spinal cord and the paraxial mesoderm in concert with the body axis elongation.

171 nd negotiate the extracellular matrix of the mesoderm in order to migrate and meet their developmenta

172 NT targets and specification of the paraxial mesoderm in tail bud precursors.

173 ot derive from somites, but mainly form from mesoderm in the pharyngeal region.

174 velopment of muscles derived from the 4th PA mesoderm in the soft palate, likely via interactions bet

175 and to muscles derived from cardiopharyngeal mesoderm in the urochordate Ciona, where a related gene

176 nforces the hypothesis that the endoderm and mesoderm in triploblastic bilaterians evolved from the b

177 e and coordinate collective migration of the mesoderm in vivo.

178 node induces a neural plate whereas the head mesoderm induces placodes.

179 No new classes of extracellular mesoderm-inducing factors have been identified in more t

180 r to what extent the molecular mechanisms of mesoderm induction are conserved between gastrula and po

181 Mesoderm induction begins during gastrulation.

182 om several vertebrate species indicates that mesoderm induction continues after gastrulation in neuro

183 rowth factor (FGF) signaling is required for mesoderm induction during gastrulation through positive

184 dingly, Rhoa or Rac1 conditional deletion in mesoderm inhibited embryonic, but not extra-embryonic me

185 spatiotemporal signaling network of endoderm-mesoderm interactions that orchestrate foregut organogen

186 he lateral edges of the neural tube-paraxial mesoderm interfaces where shear stress is highest.

187 It modulates mesoderm internalization and controls a massive posterio

188 Microtubules were required for mesoderm invagination but were not necessary for initiat

189 ommon contractile cell-shaping mechanism, as mesoderm invagination fails in Rab35 compromised embryos

190 phila embryo: premature cell division during mesoderm invagination, and native ectodermal cell divisi

191 While premature mitotic entry inhibits mesoderm invagination, which relies on apical constricti

192 in epithelia during Drosophila melanogaster mesoderm invagination.

193 The mesoderm is a key novelty in animal evolution, although

194 Here we show that canonical Wnt signaling in mesoderm is critical to confer trachea mesenchymal ident

195 ulation, the invagination of the prospective mesoderm is driven by the pulsed constriction of apical

196 The mesoderm is one of the three germ layers produced during

197 The mesoderm is specified by secreted signaling proteins fro

198 , Repo ectopic activation in the procephalic mesoderm is sufficient to repress the expression of hemo

199 GATA-binding protein 4 (GATA4) (postcardiac mesoderm), JUN and FOS families, and MEIS2 (cardiomyocyt

200 issues (e.g. neural tube, axial and paraxial mesoderm, lateral plate, ectoderm, endoderm) to drive ax

201 inated directional migration of cells in the mesoderm layer of the early embryo is essential for orga

202 5, beta-Pix mutants have an abnormally thick mesoderm layer; later, paraxial mesoderm fails to organi

203 ell delamination and migration by inducing a mesoderm-like cell fate.

204 hiPSCs are induced into incipient mesoderm-like cells (iMeLCs) using activin A and a WNT p

205 r (FGF) signaling axis required for anterior mesoderm lineage development during gastrulation.

206 events and drive naive-type piPSC along the mesoderm lineage, and, in combination with the DNA methy

207 Using a MIXL1 reporter, we explore mesoderm lineage-bias within the human pluripotent stem

208 ells (iPSC) were differentiated into lateral mesoderm (LM, aortic root) and neural crest (NC, ascendi

209 a suggests that following specification from mesoderm, local environmental cues establish the distinc

210 chymal transition (EMT) in the lateral plate mesoderm (LPM) and myoblast migration into the LPM, occu

211 The lateral plate mesoderm (LPM) forms the progenitor cells that constitut

212 ryonic stem cell (ESC)-derived lateral plate mesoderm (LPM) generates tracheal mesoderm containing ch

213 were differentiated either to lateral plate mesoderm (LPM)-like cells, the developmental ontology of

214 ve tissue progenitors from the lateral plate mesoderm (LPM).

215 ntiation, such as T and eomesodermin (EOMES; mesoderm), lymphoid enhancer-binding factor 1 (LEF1) and

216 Deletion of Sox17 specifically in the mesoderm markedly impaired endocardium development with

217 of YAP(-/-) hESCs to Activin induces cardiac mesoderm markers (BAF60c and HAND1) without activating W

218 which undergoes a complex series of endoderm-mesoderm-mediated signaling events to generate the final

219 on factor 1 (MESP1; from mesoderm to cardiac mesoderm), meis homeobox 1 (MEIS1) and GATA-binding prot

220 fibroblasts from null mutants shows that the mesoderm migration defect is correlated with decreased c

221 Regulated mesoderm migration is necessary for the proper morphogen

222 inhibited embryonic, but not extra-embryonic mesoderm migration.

223 erning of the mesoderm and FGF signaling for mesoderm migration.

224 domain does not ameliorate Znf703 effects on mesoderm, neural crest, and placodes.

225 n1 to be regulated by Lef1 in the involuting mesoderm of Xenopus embryos at gastrula stages.

226 g early stages (ie, from mesoderm to cardiac mesoderm) of cardiomyocyte differentiation remains limit

227 ed abundance of actin filaments in embryonic mesoderm only.

228 ome animal species can generate neurons from mesoderm or endoderm, but the underlying mechanisms rema

229 Here we show that mesoderm organization in mouse embryos depends on beta-P

230 he importance of endoderm-derived signals in mesoderm patterning.

231 nals in nascent mesoderm to control anterior mesoderm patterning.

232 ract, right ventricle and atrium, pharyngeal mesoderm, peripheral neurons, and hindlimbs.

233 Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of th

234 at FGF is continuously required for paraxial mesoderm (PM) induction in post-gastrula NMPs.

235 derm revealed selective deficits in anterior mesoderm populations, culminating in defects to anterior

236 ymphoid enhancer-binding factor 1 (LEF1) and mesoderm posterior BHLH transcription factor 1 (MESP1; f

237 Next, these cells progress to mesoderm precursors, proliferative nephron progenitors,

238 oreover, primate embryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse.

239 nction of T as a gatekeeper between paraxial mesoderm production and the building of the NMP pool.

240 directed differentiation through a paraxial mesoderm progenitor state that generates BAs at high eff

241 rectional Wnt signaling between endoderm and mesoderm promotes trachea development.

242 motility gradient drives paraxial presomitic mesoderm (PSM) expansion, resulting in compression of th

243 vity of signaling pathways in the presomitic mesoderm (PSM).

244 lial somites from the mesenchymal presomitic mesoderm (PSM).

245 are rhythmically produced by the presomitic mesoderm (PSM).

246 der source of origin, including the paraxial mesoderm (PXM).

247 In the Drosophila mesoderm, Ras pathway signaling specifies muscle founder

248 ry yolk sac and the origin of extraembryonic mesoderm remain unclear.

249 The precisely specification of cardiac mesoderm results in not only greater than 90% of cTnT(+)

250 -cell transcriptome analysis of Hh-deficient mesoderm revealed selective deficits in anterior mesoder

251 dent KDR(+)CD235a(+) primitive hematopoietic mesoderm revealed strong CDX gene expression within defi

252 confirm that BAP treated hESC (ESCd) lack a mesoderm signature and are a subtype of placental cells

253 xtensive morphogenesis, including splanchnic mesoderm sliding over the endoderm, results in HT format

254 endoderm (DE) and the surrounding splanchnic mesoderm (SM).

255 In contrast, mesoderm-specific deletion of Ofd1 in Mesp1-Cre; Ofdfl/Y

256 sion is repressed in the hemocyte anlagen by mesoderm-specific factors.

257 Mesoderm-specific Fgf4/Fgf8 double-mutants recapitulated

258 We show that mesoderm-specific inactivation of Npc1a results in germ

259 availability of PRKAB2 was indispensable for mesoderm specification as shown by gene expression analy

260 Understanding the mechanisms that control mesoderm specification could inform many applications, i

261 ole of Wnt signaling pathway manipulation on mesoderm specification in a dosage and time dependent ma

262 exogenous CDX4 expression exclusively during mesoderm specification resulted in a >90% repression in

263 mechanical stretching promoted BMP-dependent mesoderm specification, confirming that tissue-level for

264 gf, to determine the pattern of endoderm and mesoderm specification.

265 of beta-catenin to promote Wnt signaling and mesoderm specification.

266 that SHF population in the mouse splanchnic mesoderm (SpM-SHF) undergoes polarized morphogenesis to

267 ed RNA AK127400 in the module related to the mesoderm stage; E-box-binding homeobox 1 (ZEB1) in the m

268 coordinating the morphology and migration of mesoderm subpopulations.

269 gnaling-regulated kinase 1/2 activity in all mesoderm subtypes.

270 a also disrupted cell differentiation of the mesoderm, suggesting aberrant epithelial-mesenchymal sig

271 rce of myocardium and of the pharyngeal arch mesoderm that gives rise to skeletal muscles.

272 rdiomyocytes derive from a subset of Nkx2.5+ mesoderm that responds to canonical Wnt5b signaling to i

273 soon after segmentation from the presomitic mesoderm, the future myotome spreads across the underlyi

274 al crest, and the pectoral fin skeleton from mesoderm, the gill arches are of dual origin, receiving

275 d differentiation from PSC-derived embryonic mesoderm through hematopoietic specification and efficie

276 lineage establishment from the endoderm and mesoderm through to the organization of the primitive si

277 ntribute to the spinal cord and the paraxial mesoderm throughout axial elongation.

278 In order to produce mesoderm throughout this time, the NMps produce their ow

279 ongation by generating spinal cord and trunk mesoderm tissue.

280 astrulation that produce organizer and axial mesoderm tissues with different properties (including di

281 y networks underlying early stages (ie, from mesoderm to cardiac mesoderm) of cardiomyocyte different

282 ior BHLH transcription factor 1 (MESP1; from mesoderm to cardiac mesoderm), meis homeobox 1 (MEIS1) a

283 node and executed by FGF signals in nascent mesoderm to control anterior mesoderm patterning.

284 ugh stereotyped transitions from naive Mesp+ mesoderm to distinct fate-restricted heart and pharyngea

285 t filled with dense extracellular matrix and mesoderm to reach targets throughout the vertebrate embr

286 (HPCs) move from the anterior lateral plate mesoderm to the ventral midline, undergoing a mesenchyma

287 Embryonic and extra-embryonic mesoderm transcriptomes highlighted distinct guidance, c

288 bilateral migration along the trunk visceral mesoderm (TVM) in order to form midgut muscles.

289 a different and separable function in early mesoderm versus neural crest and placode development.

290 , the transcriptional program of the Flk1(+) mesoderm was maintained in the smooth muscle lineage, su

291 utions in individual cells of the developing mesoderm, we engineered all five disease-associated alle

292 achyury prior to the evolution of definitive mesoderm, we excised the gene using CRISPR/Cas9 in the d

293 gf8 and Fgf17 are required in the presomitic mesoderm, whereas Fgf18 is required in the somites.

294 ral gene expression in both the endoderm and mesoderm, whereas Wnt/beta-catenin acts as a genome-wide

295 of the tail bud and the posterior presomitic mesoderm, which control posterior elongation(1), exhibit

296 serves as a source for early extraembryonic mesoderm, which is supplemented with mesoderm from the g

297 ance of mesendoderm specification to cardiac mesoderm, which needs precisely regulation of Wnt in a d

298 Moreover, induction of endoderm and head-mesoderm, which require peak Nodal-signaling levels, is

299 nts were highly expressed in extra-embryonic mesoderm, while live imaging for F-actin showed abundanc

300 ) subtypes from cardiogenic versus hemogenic mesoderm with high efficiency without cell sorting.