ライフサイエンスコーパス: mesodermal cell

1 the separation and intercalation of dividing mesodermal cells.

2 ly coordinated manner across endothelial and mesodermal cells.

3 th similarly exhibit an altered migration of mesodermal cells.

4 entiation of neighboring neuroectodermal and mesodermal cells.

5 foster tissue repair, and differentiate into mesodermal cells.

6 for FGF-dependent migrations of tracheal and mesodermal cells.

7 site, binds to nuclear proteins from several mesodermal cells.

8 the embryo before navigating toward gonadal mesodermal cells.

9 endodermal and extraembryonic but mixed with mesodermal cells.

10 extension for neural deep cells than for the mesodermal cells.

11 ly described for convergent extension of the mesodermal cells.

12 ific somatic muscle precursors and glia-like mesodermal cells.

13 nal-mediated induction of a subpopulation of mesodermal cells.

14 ing sorted nuclei and interfered with Ubx in mesodermal cells.

15 iate into Pax6(+)-neural precursor cells and mesodermal cells.

16 this largely twist-independent population of mesodermal cells.

17 genitor, the hemangioblast, or directly from mesodermal cells.

18 efinitive, in mice are derived from Flk-1(+) mesodermal cells.

19 rect cell fate specifications of a subset of mesodermal cells.

20 r the formation of FLK1-expressing (FLK1(+)) mesodermal cells.

21 re sufficient to impose these fates on other mesodermal cells.

22 for delivering high Wg levels to a subset of mesodermal cells.

23 rtant role for the non-constricting, lateral mesodermal cells adjacent to the constriction domain ('f

24 ing of the apical surface of the presumptive mesodermal cells and a constriction of their apical diam

25 s characteristics of early nondifferentiated mesodermal cells and can be induced to express either my

26 ment, the PAAs emerge from nkx2.5-expressing mesodermal cells and connect the dorsal head vasculature

27 proliferating and differentiated neural and mesodermal cells and is particularly high in developing

28 lls (MAPCs) that can differentiate into most mesodermal cells and neuroectodermal cells in vitro and

29 By imaging fluorescently labeled mesodermal cells and surrounding extracellular matrix si

30 1 is sufficient to induce additional gonadal mesodermal cells and to alter the temporal course of gen

31 strulation and heart tube formation to track mesodermal cells and to reconstruct lineage trees and 3D

32 ially-injected undifferentiated-iPSCs, day 4 mesodermal cells, and day 8, day 20, and day 30 purified

33 ng gastrulation in involuting endodermal and mesodermal cells, and in vertebrates at least, this expr

34 uring gastrulation in endodermal or nonaxial mesodermal cells, and it has been suggested that nonnoto

35 d the Wnt-beta-catenin pathway in these limb mesodermal cells are critical for muscle patterning.

36 tail bud regions, which are sites where new mesodermal cells are generated.

37 intact in mutant epiblasts, the prospective mesodermal cells are not recruited into the primitive st

38 During Drosophila embryogenesis, mesodermal cells are recruited to form a complex pattern

39 This structure, where the first mesodermal cells arise, marks the posterior aspect of th

40 e identified 27 genes expressed in glial and mesodermal cells associated with the midline cells.

41 ellular source of an inducer acts to pattern mesodermal cells at a distance in Xenopus embryos, it do

42 Ch-en is also expressed in a small group of mesodermal cells at the base of the chaetal sacs.

43 rphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP.

44 n of the limb bud and in a discrete group of mesodermal cells at the midproximal posterior margin.

45 ction in stimulating migration of presomitic mesodermal cells away from the PS and a second cell auto

46 ead mesodermal cell (HMC), a non-contractile mesodermal cell bearing molecular and functional similar

47 s in a more episodic manner than that of the mesodermal cells because the neural cells' mediolateral

48 The recruited mesodermal cells become epithelial and differentiate int

49 By late gastrulation, mesodermal cells become packed as they engage in planar

50 e that controls dynamic actin remodeling and mesodermal cell behaviors during Xenopus gastrulation.

51 Analyses of mesodermal cell behaviors revealed that Galpha(12/13) ar

52 w C-cadherin-based contacts with neighboring mesodermal cell bodies.

53 not essential for the initial commitment of mesodermal cells, but are crucial for maintenance of mes

54 In the grasshopper embryo, large mesodermal cells called muscle pioneers extend between t

55 hat the E(+)F(+) fraction at E7.5 represents mesodermal cells competent to respond to TGFbeta1, BMP4,

56 During Drosophila gastrulation, the ventral mesodermal cells constrict their apices, undergo a serie

57 ecause the production of both endodermal and mesodermal cells continues until the late prism stage, w

58 It is notable that the AER changes and mesodermal cell death occur earlier in the Shh(-/-) fore

59 reatic transcription factor causes increased mesodermal cell death, and the severity of defects is de

60 During gastrulation, mesodermal cells derived from distinct regions are desti

61 ectomesodermal lineages to prepare isogenic mesodermal cell-derived chondrocytes (MC-Chs) and neural

62 at function in the processes of neuronal and mesodermal cell development.

63 Vascular development begins when mesodermal cells differentiate into endothelial cells, w

64 w that, in some regions of the embryo, total mesodermal cell displacements are mostly due to convecti

65 of avian blastoderm cells, which replicated mesodermal cell diversification.

66 ate during their convergent extension as the mesodermal cells do, we predict that a given intercalati

67 partitioned into the nascent ectodermal and mesodermal cells during cleavage and early gastrulation

68 nction of the homeobox gene tinman in dorsal mesodermal cells during early embryogenesis.

69 The ectodermal cells contact migrating mesodermal cells during early gastrulation, concurrent w

70 In addition, Smad8 inhibits involution of mesodermal cells during gastrulation, a phenotype that i

71 suggest that Brn-4 enhances the survival of mesodermal cells during the mesenchymal remodeling that

72 umulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation.

73 Pw1 is initially expressed in all mesodermal cells early in development; however, its main

74 antation embryonic yolk sac, where clumps of mesodermal cells express PECAM before the development of

75 e, we show that in zebrafish pectoral girdle mesodermal cells expressing gli3, a transcription factor

76 phila FGF is used, only in males, to recruit mesodermal cells expressing its receptor to become part

77 Mesodermal cells fail in their dorsal migrations after g

78 In the absence of Gravin, paraxial mesodermal cells fail to shut down the protrusive activi

79 Our data indicate that miR-200a represses mesodermal cell fate after a small lesion injury in the

80 cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell diffe

81 ression of Hox signatures, and neural versus mesodermal cell fate choice, within axial progenitors.

82 to a dramatic shift in posterior neural and mesodermal cell fate decisions and the body elongation p

83 eir self-renewal and balancing neural versus mesodermal cell fate decisions.

84 ishing the proper balance between neural and mesodermal cell fate determination in mouse embryos and

85 nly in adipocyte differentiation but also in mesodermal cell fate determination.

86 he results suggest that the establishment of mesodermal cell fate requires the proper restriction of

87 A role for CeTwist in postembryonic mesodermal cell fate specification was indicated by ecto

88 ds to gastrulation defects without affecting mesodermal cell fate, whereas knockdown of USP12 in Xeno

89 iptional regulators, which, in turn, control mesodermal cell fate.

90 transcriptional regulator to establish early mesodermal cell fate.

91 for initial specification of endodermal and mesodermal cell fate.

92 e important to ensure appropriate control of mesodermal cell fate.

93 The two signals are known to regulate local mesodermal cell fates and to signal to the endoderm.

94 epithelial phenotype is to actively suppress mesodermal cell fates during early development.

95 a transcription factor that is required for mesodermal cell fates in all animals studied to date.

96 role in the decision between ectodermal and mesodermal cell fates in leech.

97 but they frequently lack the endodermal and mesodermal cell fates normally specified by a transcript

98 late is radially symmetrical with respect to mesodermal cell fates, single blastomeres of four cell s

99 o self-renew and differentiate into multiple mesodermal cell fates.

100 asts (Flk1(+)/PECAM(-)), or undifferentiated mesodermal cells (Flk1(-)/PECAM(-)).

101 hat it exerts critical effects shortly after mesodermal cells form by gastrulation.

102 hat Gravin is required for the conversion of mesodermal cells from a highly migratory behavior to the

103 posterior due to the addition of neural and mesodermal cells from a neuromesodermal progenitor (NMp)

104 strating its ability to remodel chromatin in mesodermal cells from developing embryos and proving a m

105 In addition, although dorsal mesodermal cells from lithium- or Wnt-exposed embryos ar

106 nomic binding and transcription profiling in mesodermal cells from mouse and human Pax3-induced embry

107 underlying this transition, we have isolated mesodermal cells from murine embryos at E7.5 with charac

108 ture of the cellular basis and regulation of mesodermal cell fusion and has important implications re

109 erive, respectively, from paraxial and axial mesodermal cell groups.

110 activation results in p53- and p21-dependent mesodermal cell growth arrest.

111 ichments are developmentally regulated, with mesodermal cells having high apical PIP(3) while germban

112 ell of previously unknown function, the head mesodermal cell (hmc) in C. elegans.

113 ory programs, we studied the C. elegans head mesodermal cell (HMC), a non-contractile mesodermal cell

114 The extent to which specialized mesodermal cells homologous to the founders and pioneers

115 is derived from both neural crest cells and mesodermal cells; however, the majority of the bone, car

116 ilure of gastrulation movements, even though mesodermal cell identities are specified.

117 We identify a population of mesodermal cells in a developing invertebrate, the marin

118 blebby transitional morphology of involuting mesodermal cells in a vertebrate embryo.

119 d a population of lateral plate-derived limb mesodermal cells in both chick and mouse that expresses

120 the microtubule cytoskeleton of the visceral mesodermal cells in differentiation of the endodermal ce

121 wo genes are activated in specific groups of mesodermal cells in the anterior portions of each parase

122 During chicken yolk sac (YS) growth, mesodermal cells in the area vasculosa follow the migrat

123 y expressed in the nucleus of endodermal and mesodermal cells in the cardiogenic plate.

124 During avian gastrulation, presumptive mesodermal cells in the dorsal epiblast ingress through

125 Here we demonstrate that individual mesodermal cells in the heart field gave rise to a clone

126 l cells efficiently promote the emergence of mesodermal cells in the neighboring population through s

127 hat identifies impaired migration of nascent mesodermal cells in the primitive streak as the morphoge

128 ired to determine the appropriate numbers of mesodermal cells in the third midgut chamber.

129 epithelial cells of the vulva as well as the mesodermal cells in the uterus of the somatic gonad.

130 We found that migrating mesodermal cells in vivo respond to Slit as both an attr

131 ibroblast growth factors (FGFs), made by the mesodermal cells, in promoting the proliferation, buddin

132 First, axial mesodermal cells, including prospective notochord, stop

133 Mesodermal cells induced after 7 days of monolayer cultu

134 Apical constriction of mesodermal cells initiates but is not completed.

135 he cell behaviors associated with neural and mesodermal cell intercalation, raising the possibility t

136 Hif-p4h-2 in Forkhead box D1 (FoxD1)-lineage mesodermal cells interferes with the normal HF developme

137 ic transcription factor Slouch, we asked how mesodermal cells interpret the steady flow of Wg.

138 The organization of mesodermal cells into endothelial and hematopoietic cell

139 The subdivision of mesodermal cells into muscle and non-muscle cells is cru

140 erentiation and propels a specific subset of mesodermal cells into somatic myogenesis.

141 ntinues to play additional roles, allocating mesodermal cells into the body wall muscle fate and patt

142 associated with temporal patterning of early mesodermal cells into the distinct populations of CPs th

143 rected migration of individual lateral-plate mesodermal cells into the future limb-bud-producing regi

144 MCs fail to repress the transfating of other mesodermal cells into the skeletogenic lineage.

145 Acquisition of a cardiac fate by embryonic mesodermal cells is a fundamental step in heart formatio

146 ion of Xdsh at the membrane of normal dorsal mesodermal cells is consistent with Xdsh controlling cel

147 ered that hlh-8 expression in differentiated mesodermal cells is controlled by two well-conserved E b

148 episodic, whereas the protrusive activity of mesodermal cells is more continuous.

149 on of transient, serially repeated blocks of mesodermal cells known as somites.

150 in the Drosophila embryo defines a subset of mesodermal cells known as the muscle "pioneer" or "found

151 To explore the diversification of individual mesodermal cells, labeled QCE-6 cells were incorporated

152 polarizing cell movements between different mesodermal cell layers.

153 on, ectopic expression of cas in presumptive mesodermal cells leads to their transfating into endoder

154 Previous studies have shown that this quail mesodermal cell line possesses characteristics of early

155 e repressing their transformation into other mesodermal cell lineages (e.g. myocytes).

156 , sea urchin embryos eventually form various mesodermal cell lineages and a gut consisting of fore-,

157 age markers and could be differentiated into mesodermal cell lineages, including osteocytes and adipo

158 ins regulate the differentiation of distinct mesodermal cell lineages.

159 activity is produced by a selective group of mesodermal cells located adjacent to the choice point.

160 positive domain is continuous with a central mesodermal cell mass ventral and lateral to the dorsal a

161 fferentiation generates distinct lineages of mesodermal cells, matching YS and allantois development.

162 rowth cones approach the choice point, these mesodermal cells migrate away, suggesting that unplugged

163 The recruited mesodermal cells migrate into the disc late in developme

164 bronectin-rich extracellular matrix on which mesodermal cells migrate using the same alpha5beta1 inte

165 Mesodermal cell migration defects in toddler mutants res

166 lts suggest that Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

167 e results suggest a requirement for paraxial mesodermal cell migration during spinal neural tube clos

168 ush is also required for mesodermal cell migration early in embryogenesis, where

169 We now report that proper mesodermal cell migration is dependent on the function o

170 However, htl-dependent mesodermal cell migration is not affected in dlp mutant

171 roblast growth factor (FGF) signaling guides mesodermal cell migration; however, we found some direct

172 verexpression of Zic1 and Pax3 in the 10T1/2 mesodermal cell model results in enrichment of these fac

173 During this process, mesodermal cells move toward the future dorsal side of t

174 -reveals a critical time window during which mesodermal cell movements and gene expression are suppre

175 During amphibian gastrulation, mesodermal cell movements depend on both cell-cell and c

176 The biophysical mechanisms driving mesodermal cell movements during gastrulation in amniote

177 A subpopulation of mesodermal cells moving ventrally from the somatopleural

178 sal closure cells), in a small percentage of mesodermal cells (muscle pioneers), and throughout the d

179 evel syndecan-3 expression in the outgrowing mesodermal cells of explants of the posterior mesoderm o

180 In the mouse embryo, the splanchnic mesodermal cells of the anterior heart field (AHF) migra

181 abundantly expressed by the distal subridge mesodermal cells of the chick limb bud and also by the A

182 lycan that is highly expressed by the distal mesodermal cells of the chick limb bud that are undergoi

183 9 at full germ-band extension in a subset of mesodermal cells organized in a stereotypic pattern in e

184 e close ontogenic origins, and that an early mesodermal cell population has the potential to differen

185 The recent finding that distinct mesodermal cell populations are segregated within the no

186 We characterized induced mesodermal cell populations using single-cell and bulk t

187 bation of endothelial/myeloid specification, mesodermal cells possess a remarkable plasticity enablin

188 nstrated that Runx1 is expressed in yolk sac mesodermal cells prior to the establishment of the blood

189 is, in enhancing FGF signaling that leads to mesodermal cell proliferation without induction of myoge

190 RA, produced by newly generated mesodermal cells, provides feedback that initiates NMP g

191 s raises the question of how the presumptive mesodermal cells recognize the multiple TGF-beta signals

192 In insects, specialized mesodermal cells serve as templates to organize myoblast

193 Mesodermal cells signal to neighboring epithelial cells

194 Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic da

195 itor field, possibly representing an ancient mesodermal cell state that predates the primordial verte

196 oncomitant induction of an ambivalent neural/mesodermal cell state.

197 ls than wild-type and altered proportions of mesodermal cell subpopulations.

198 r Twist and its own gene product in visceral mesodermal cells, supporting the idea that twist and NK-

199 SCL is first expressed in mesodermal cells that give rise to embryonic blood cells

200 1) TAL1 and Flk1 are coexpressed in isolated mesodermal cells that give rise to endothelial cells and

201 ement generates a stereotyped arrangement of mesodermal cells that is essential for their correct pat

202 with decreased Notch activity originate from mesodermal cells that normally produce erythrocyte proge

203 fic RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adja

204 tructures differentiate from extra-embryonic mesodermal cells that underlie the visceral endoderm.

205 se that Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signal

206 of SoxB1 proteins in the limb bud confers on mesodermal cells the potential to activate neural-specif

207 In the zebrafish embryo, a subset of mesodermal cells, the adaxial cells, delineates the pros

208 cation and differentiation of the non-muscle mesodermal cells, the coelomocytes (CCs).

209 the muscle pattern is organised by specific mesodermal cells, the founder myoblasts, which initiate

210 ct towards a group of posterior intermediate mesodermal cells, the metanephric mesenchyme, and induce

211 s mediated by regulation of Wnt signaling in mesodermal cells through activation of integrin-beta1.

212 en implicated in the commitment of embryonic mesodermal cells to a hematopoietic fate in a number of

213 ht to provide a signal that induces adjacent mesodermal cells to adopt a cardiac fate.

214 Vasculogenesis, the differentiation of mesodermal cells to angioblasts and the subsequent forma

215 in acts within a subpopulation of splanchnic mesodermal cells to control an essential early step in s

216 regulates the chromatin landscape of nascent mesodermal cells to define the temporal and spatial patt

217 This domain is crucial for the allocation of mesodermal cells to distinct fates, such as heart, gut a

218 and Gata2 is required in both ectodermal and mesodermal cells to enable mesoderm to commit to a hemat

219 Founders appear to recruit fusion-competent mesodermal cells to establish a particular muscle fiber

220 oup Orthoptera, the induction of a subset of mesodermal cells to form the primordial germ cells (PGCs

221 as a central role in the induction of dorsal mesodermal cells to form the Spemann organizer.

222 indicate that RA inhibits the commitment of mesodermal cells to hematopoietic fates, functioning dow

223 tive feedback loop that limits allocation of mesodermal cells to the extreme ventral fate, with direc

224 ion must occur at or prior to the arrival of mesodermal cells to the heart field.

225 fy mesoderm and the subsequent allocation of mesodermal cells to the somatic muscle fate.

226 tive neural ectodermal cells, or upon dorsal mesodermal cells, to cause a loss of anterior pattern.

227 ability of GATA5 to respecify ectodermal and mesodermal cells towards endoderm suggests an important

228 protein (Bmp) signaling is known to regulate mesodermal cell type determination along the medio-later

229 One mesodermal cell type resulting from this in vivo inducti

230 mal specification and the differentiation of mesodermal cell types (twist, snailA, snailB, forkhead,

231 requires inductive interactions with diverse mesodermal cell types and the action of transcription fa

232 Neuronal and mesodermal cell types are generated in separate cell lin

233 In C. elegans, many mesodermal cell types are made by descendants of the pro

234 a significant delay in the formation of all mesodermal cell types examined.

235 icular interest because it induces different mesodermal cell types in a concentration-dependent manne

236 beta family member activin induces different mesodermal cell types in a dose-dependent fashion in the

237 ne at different embryonic stages and in four mesodermal cell types is governed by the binding of mult

238 and perhaps other BMP inhibitors secreted by mesodermal cell types that flank the ventral neural tube

239 ly, in oral or aboral domains, presaging the mesodermal cell types that will emerge.

240 is required for a variety of ectodermal and mesodermal cell types, including cells in the hindgut; (

241 stage of embryogenesis, generates primarily mesodermal cell types, including pharynx cells, body mus

242 LvNumb is necessary for the specification of mesodermal cell types, including pigment cells, blastoco

243 ry and sufficient for the development of two mesodermal cell types, pigment cells and blastocoelar ce

244 lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types

245 ioserosa as well as different ectodermal and mesodermal cell types.

246 may function differentially in neuronal and mesodermal cell types.

247 s for the normal development of neuronal and mesodermal cell types.

248 and that the veg2 lineage also gives rise to mesodermal cell types.

249 oliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fa

250 During gastrulation, zebrafish mesodermal cells undergo a series of conversions from am

251 on with or immediately after subducting, the mesodermal cells undergo an epithelial-to-mesenchymal tr

252 The resulting unspecified mesodermal cells undergo programmed cell death.

253 ientation and migration behaviors of lateral mesodermal cells undergoing convergence and extension mo

254 -11/planar cell polarity signaling polarizes mesodermal cells undergoing convergent extension during

255 tes cell polarization and axial alignment of mesodermal cells undergoing gastrulation independent of

256 ess zone, the highly proliferating posterior mesodermal cells underneath the apical ectodermal ridge

257 files of wild-type and jumu loss-of-function mesodermal cells, we identified nebbish (neb), a kinesin

258 Prx1 promotes EC differentiation, fetal lung mesodermal cells were transfected with full-length Prx1

259 Its anterior daughter, MS, makes primarily mesodermal cells, while its posterior daughter E generat

260 ntified unanticipated regulatory networks in mesodermal cells with growth-suppressive function, expos

261 tive within the M lineage and in a number of mesodermal cells with nonstriated muscle fates.

262 tic stem cells (HSCs) are first derived from mesodermal cells within a region of the embryonic para-a

263 undreds of ectodermal cells and internalized mesodermal cells within Drosophila embryos over 2 hours

264 common or separate progenitor populations of mesodermal cells within the heart field.

265 n, canonical Wnts promote the recruitment of mesodermal cells within this region into the pacemaker l