ライフサイエンスコーパス: metabolic control

1 -kinase (PI3K)/Akt pathway is at the core of metabolic control.

2 nvironment is critical to the maintenance of metabolic control.

3 ized PSI proteins in growth possibly through metabolic control.

4 family member involved in redox sensing and metabolic control.

5 protein function is a critical component of metabolic control.

6 m by which NO(3)(-) supplementation improves metabolic control.

7 oderators of cardiovascular disease risk and metabolic control.

8 IRT1 suggest that this response may be under metabolic control.

9 r a reduction of the islet mass required for metabolic control.

10 and function requires efficient and precise metabolic control.

11 gnaling that is crucial to leptin action and metabolic control.

12 rmone (TH), reflecting its ancestral role in metabolic control.

13 tanding the role of allosteric regulation in metabolic control.

14 ent on the nutrient conditions, suggesting a metabolic control.

15 apping with centers for feeding behavior and metabolic control.

16 ary for mannitol biosynthesis is under tight metabolic control.

17 s of the RNA-protein regulatory interface in metabolic control.

18 ection rates with similar graft function and metabolic control.

19 tabolism, patient size, and desired level of metabolic control.

20 h and differentiation of tissues involved in metabolic control.

21 e role of elevated circulating bile acids in metabolic control.

22 etic patients can be ameliorated by improved metabolic control.

23 in other variables such as hypertension and metabolic control.

24 chemoreceptors to resting cardiovascular and metabolic control.

25 ignal transduction, hormonal regulation, and metabolic control.

26 ws correlation with retinopathy severity and metabolic control.

27 e used safely to have longer-term effects on metabolic control.

28 Ces1/Ces1g) has been shown to play a role in metabolic control.

29 dge of the gastrointestinal contributions to metabolic control.

30 nerve terminals as critical sites of proper metabolic control.

31 critical roles in neuronal functionality and metabolic control.

32 healthy hepatic Ca(2+) balance and systemic metabolic control.

33 tin has a broad spectrum of functions beyond metabolic control.

34 be involved in so far unknown mechanisms of metabolic control.

35 tion, continuation and dynamic analyses, and metabolic control.

36 g to the significance of (posttranslational) metabolic control.

37 lasticity of these limits, as well as a high metabolic control.

38 ciated with reduced body weight and improved metabolic control.

39 (Cdk) with multiple roles in cell cycle and metabolic controls.

40 siologically and speaks to a higher level of metabolic control?

41 3) Is ATP modulation of transport subject to metabolic control?

42 94 showed that 29% of patients had excellent metabolic control (a hemoglobin A1c [HbA1c] level < or =

43 risk factors, especially diabetics with poor metabolic control, a long duration of the disease, and e

44 patients showed graft function with improved metabolic control (A1c, fasting glycemia, and metabolic

45 The improved metabolic control achieved by bilirubin-treated mice was

46 ay be particularly important in appetite and metabolic control, although the genetics of human obesit

47 Metabolic control analyses confirm that the control is w

48 Sensitivity and metabolic control analyses identified expected key enzym

49 marily in theories of metabolic control, and metabolic control analysis (MCA) is an important example

50 this framework, we then adapt the methods of metabolic control analysis (MCA) to determine which modi

51 glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and

52 Metabolic control analysis allows the study of metabolic

53 of mammalian muscle glycogen synthesis using metabolic control analysis and concluded that glycogen s

54 s and metabolic flux, and the application of metabolic control analysis and metabolic flux analysis t

55 Some recent misunderstandings of metabolic control analysis have led to the claim that th

56 e have also developed a novel application of metabolic control analysis likely to have broad applicat

57 mics of these networks by approaches such as metabolic control analysis may provide new insights into

58 measured and the flux control determined by metabolic control analysis of data, which shows that thi

59 Metabolic control analysis revealed that G6P concentrati

60 steady state kinetics as a means of applying metabolic control analysis to hierarchical biochemical s

61 t a sensitivity analysis which is similar to metabolic control analysis used in the analysis of bioch

62 Metabolic control analysis, co-invented by Reinhart Hein

63 ned in vivo kinetic parameters were used for metabolic control analysis, in which flux control coeffi

64 ly kinetic Michaelis-Menten representations, metabolic control analysis, or biochemical systems theor

65 In the top down approach to metabolic control analysis, reactions are grouped togeth

66 results are presented as a generalization of Metabolic Control Analysis, which has been concerned pri

67 xyxylulose 5-phosphate synthase (DXS), using metabolic control analysis.

68 tion theorem (FST) is a central principle of metabolic control analysis.

69 he well-established (log)linear formalism of metabolic control analysis.

70 etabolism has been previously analysed using metabolic control analysis.

71 linear algebraic equations (NAEs), including metabolic control analysis; (iii) solving the non-linear

72 A theoretical metabolic-control-analysis approach has been used to stu

73 chestrating selective promoter activation in metabolic control and a model by which hnRNPs can impact

74 rtheless, clear benefits in terms of optimal metabolic control and absence of severe hypoglycemia are

75 ock pathways reported to be both involved in metabolic control and activated by HCMV infection.

76 ole of such extracellular miRNAs in systemic metabolic control and as potential biomarkers of metabol

77 tudies have found that sleep loss can impair metabolic control and body weight regulation.

78 receptor (IR) signaling is central to normal metabolic control and dysregulated in prevalent chronic

79 As a first step in linking metabolic control and genetic regulatory networks, this

80 Poor metabolic control and host genetic predisposition are cr

81 Troglitazone therapy improved metabolic control and increased body fat in patients wit

82 aling pathways related to stress resistance, metabolic control and inflammation, and therefore provid

83 nt NOD-SCID and CD1 strains were studied for metabolic control and islet function and gene regulation

84 indicators of suboptimal cardiovascular and metabolic control and lifestyle choices such as alcohol

85 ave important implications for understanding metabolic control and metabolic diseases.

86 ing pathways and has long been implicated in metabolic control and mitochondrial function.

87 ssed the unanswered research questions about metabolic control and non-insulin-dependent diabetes mel

88 dings reveal a role of the heart in systemic metabolic control and point to MED13 and miR-208a as pot

89 et triggers CNS immune activation, impairing metabolic control and promoting obesity and Type 2 Diabe

90 plementation of precision therapy to improve metabolic control and quality of life.

91 ched, with functions relating to cell cycle, metabolic control and signal transduction.

92 However, good metabolic control and standard therapy fail to prevent C

93 naling in uridine homeostasis and consequent metabolic control and thermoregulation.

94 SREBP1 suppression was inversely related to metabolic control and was normalized by 3 h of in vivo h

95 cin-induced diabetes was closely matched for metabolic control and was transplanted with 5,000 IEQ/kg

96 aluate the association of periodontitis with metabolic control, and 3) to evaluate periodontitis in d

97 status and cardiovascular disease, diabetes metabolic control, and a number of adverse pregnancy out

98 nt mice suppresses FoxO1, a central node for metabolic control, and entirely prevents the development

99 neral role for the central nervous system in metabolic control, and have revealed the importance of a

100 This work reveals mechanisms of metabolic control, and identifies therapeutic targets to

101 t of these is dealt primarily in theories of metabolic control, and metabolic control analysis (MCA)

102 asma concentrations of inflammatory markers, metabolic control, and the effect of the Pro12Ala PPARG

103 t role in tumor proliferation, angiogenesis, metabolic control, and the efficacy of cytotoxic therapy

104 Insulin physiology and metabolic control are far more complex than previously t

105 The brain's contributions to metabolic control are more readily revealed and play a c

106 most advantageous circumstances of excellent metabolic control, are characterized by dynamic changes,

107 d progression, particularly those related to metabolic control, are poorly understood.

108 omyces cerevisiae) include the stringency of metabolic control at the level of oxygen consumption, th

109 erence and facilitate evaluation of a GFD on metabolic control, bone health and patient quality of li

110 For the attainment of intensive IHD metabolic control (BUNa = 60 mg/dl) at steady state, a r

111 r hand, for the attainment of intensive CRRT metabolic control (BUNs = 60 mg/dl), required urea clear

112 cent of offspring whose mothers did not have metabolic control by 20 weeks' gestation had a General C

113 se data illustrate an auxiliary mechanism of metabolic control by a morphogenic pathway with relevant

114 The reason for this secondary metabolic control by RibR is to couple sulfur metabolism

115 halamic neuropeptide oxytocin contributes to metabolic control by suppressing eating behavior.

116 Emerging evidence indicates that metabolic control by the circadian clock underpins speci

117 c and developmental changes, as in mammalian metabolic control by the insulin receptor.

118 , the model predicts that the same degree of metabolic control cannot be achieved even with daily IHD

119 Here we analyse glycaemic and metabolic control, cardiovascular risk, medication use,

120 espite targeting the hypothalamus as a major metabolic control center, we did not detect hypothalamic

121 hat enable the experimental determination of metabolic control coefficients, and demonstrate these by

122 Simple, reliable methods of defining metabolic control combined with a feedback system in the

123 ering of the 'sperm RNA code' with regard to metabolic control could move the field towards translati

124 Poor metabolic control despite maximal medical therapy prompt

125 iabetes management in light of the plateaued metabolic control, diversifying causes of death, and con

126 Metabolic control during pregnancy was good in all cases

127 rioration in insulin production and improves metabolic control during the first year of type 1 diabet

128 -regulated brain circuits that contribute to metabolic control, enabling the discovery of novel brain

129 rotein kinase family, which is essential for metabolic control, energy homeostasis, and stress respon

130 These data highlight a key metabolic control event early in exhaustion and suggest

131 Clinicians need to ensure early and thorough metabolic control for all patients affected by COVID-19.

132 free and overall islet survival and superior metabolic control for animals treated with recipient as

133 ate how heat shock factor 1 (HSF1) uncouples metabolic control from proteostatic regulation and unvei

134 Estimates of metabolic control from records of diabetic patients in W

135 sition, accompanied by epigenetic changes in metabolic control genes.

136 a, and these enzymes have been implicated in metabolic control, growth control, and a variety of stre

137 omplex interplay between virus and host over metabolic control has only just begun to be deconvoluted

138 ddition, rational design approaches based on metabolic control have been reported to increase metabol

139 tion rates, including cytomegalovirus, or in metabolic control (HgbA1C, hypertension, and cholesterol

140 In addition, metabolic control (HgbA1C, hypertension, serum cholester

141 tified and validated by re-testing: two were metabolic controls (HIS3, ATR1), five had established ro

142 scriptional regulation as a central event in metabolic control hormones, drugs, and xenobiotics in th

143 axis emerges as a phylogenetically conserved metabolic control hub for fasting-mediated autophagy enh

144 ntly correlated with the amount of fat loss, metabolic control impairment, and severity of liver inju

145 e of transplanted islets required to achieve metabolic control in a mouse model of type 1 diabetes.

146 ort the importance of maintaining meticulous metabolic control in children with urea cycle disorders,

147 drial activity to redox needs and implicates metabolic control in coordination of stress and developm

148 However, treatment directed at deranged metabolic control in diabetes is effective only in anima

149 mined whether a low-glucose regimen improves metabolic control in diabetic patients undergoing perito

150 al regulator that sits right at the heart of metabolic control in Escherichia coli.

151 We discuss the implications for metabolic control in facultative anaerobes, and for ener

152 FADS3 AT, conserved in primates and under metabolic control in human cells, are a putative mediato

153 id hormone activation and thus may influence metabolic control in humans.

154 to reach a state of ketosis that may improve metabolic control in humans.

155 hat a single drink of KE may acutely improve metabolic control in individuals with obesity.

156 aning (SRP) may help to improve glycemic and metabolic control in patients with chronic periodontitis

157 fectiveness of SRP in improving glycemic and metabolic control in patients with CP and DM2.

158 ta-cell actions of GLP-1 analogs may improve metabolic control in patients with insulinopenic diabete

159 etreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but it

160 e primary care setting are needed to improve metabolic control in patients with NIDDM.

161 ls from GLT stress could potentially improve metabolic control in patients with T2D.

162 However, apatite is precipitated under metabolic control in shoot trichomes, and by evaporative

163 r of transplanted islets required to achieve metabolic control in STZ-induced diabetic mice.

164 positive impact of islet transplantation on metabolic control in T1 diabetes.

165 tool for investigating mechanisms underlying metabolic control in the heart.

166 and emphasize the importance of PKA-mediated metabolic control in the pathogenic potential of A. fumi

167 ated with elevated GLP-1 levels and improved metabolic control in these animals, resulting in improve

168 However, metabolic control in these neurons is different.

169 These studies indicate that decreased metabolic control in type 2 diabetics results in increas

170 e independent and tissue-specific effects on metabolic control in vivo.

171 provides evidence for multiple mechanisms of metabolic control in yeast aging.

172 Insulin pump therapy may improve metabolic control in young patients with type 1 diabetes

173 evealed the specificity of leptin signals in metabolic control, including the role for leptin-STAT3 s

174 eneral Cognitive Index decreased as weeks to metabolic control increased (r = -0.58; P<.001).

175 c women because of insulin therapy and tight metabolic control, infants of diabetics still experience

176 ripherally related to respiration, including metabolic control, inflammation, and cell fate.

177 Poor metabolic control, insulin treatment, long diabetes dura

178 besity or insulin resistance may be based on metabolic control intrinsic to skeletal muscle.

179 Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity en

180 We conclude that poor metabolic control is associated with significant patholo

181 Among these processes, metabolic control is coming to the forefront, because it

182 This metabolic control is exerted via inhibitory phosphorylat

183 In glycolysis, metabolic control is frequently considered vested in cla

184 mellitus, especially in individuals in whom metabolic control is poor, and cigarette smoking.

185 ion of the C. elegans serotonergic system in metabolic control is similar to mammalian serotonergic i

186 Under normal circadian function, metabolic control is temporally coordinated across tissu

187 evel understanding of temporal molecular and metabolic controls is needed to define the cellular beha

188 rdependency, by balancing contractility with metabolic control, is crucial for cells of the cardiovas

189 Improved metabolic control may also decrease mortality rates.

190 Metabolic control may be relevant for refining inclusion

191 ubstrate supply, the nonlinear properties of metabolic control may induce complex dynamic behavior.

192 off insulin for 24 months and shows improved metabolic control (mean HbA(1c) 7.58 before and 6.18% af

193 ic genome activation, suggesting a conserved metabolic control mechanism underlying early pre-implant

194 sults and warrants a critical reappraisal of metabolic control mechanisms in health and disease.

195 te pathway in Mtb relies on a combination of metabolic control mechanisms, is required for persistenc

196 on the integration of central and peripheral metabolic control mechanisms.

197 Using additional transcriptional and metabolic control methods, we shift the response thresho

198 The significant improvement in metabolic control observed for the patients described in

199 A number of recent studies have implicated metabolic control of adenosine generation at sites of ti

200 nd also provides a mechanism contributing to metabolic control of apoptosis.

201 tabolic needs, yet little is known about the metabolic control of B cell fate.

202 e gene regulatory mechanisms involved in the metabolic control of cardiac fatty acid oxidative flux,

203 We investigated the metabolic control of cardiac glycolysis and explored the

204 ng enzymes, are emerging as key mediators of metabolic control of cell fate.

205 ng enzymes, are emerging as key mediators of metabolic control of cell fate.

206 In contrast, we identified significant metabolic control of circadian function across a series

207 e results implicate circadian, sleep, and/or metabolic control of CPEB-mediated subcellular trafficki

208 These findings show that metabolic control of cytokinin could provide the key to

209 exposed to the flow of medium, suggesting a metabolic control of detachability.

210 Metabolic control of development is not a new idea and c

211 Optimum metabolic control of diabetes is important for preventio

212 Poor metabolic control of diabetes mellitus (DM) has often be

213 ion in vitro and in vivo and may improve the metabolic control of diabetes.

214 tment of periodontal disease on the level of metabolic control of diabetes.

215 findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic cl

216 th an insulin receptor antagonist, revealing metabolic control of expression.

217 gulated lipid metabolism; however, the basic metabolic control of fatty acid metabolism in neurons re

218 implicate opioid transmission in hedonic and metabolic control of feeding, although roles for specifi

219 ll morphology, chemokine expression, and the metabolic control of fibroblasts.

220 The PEPCK-C gene provides a model for the metabolic control of gene transcription.

221 Having an established influence in the metabolic control of glucose and lipids, herein, we desc

222 ntial link between cell-cycle regulation and metabolic control of glucose homeostasis.

223 This deficiency in metabolic control of glucose production critically depen

224 Periodontal treatment and metabolic control of her diabetes resulted in significan

225 is method is a long-needed tool to study the metabolic control of histone methylation.

226 it is not currently possible to measure the metabolic control of histone methylation.

227 tify HIF1alpha-regulated glycolysis as a key metabolic control of IFN-gamma production in hypoxic T c

228 recent work addressing metabolic changes and metabolic control of inflammation and immunity.

229 ew recent work addressing tissue hypoxia and metabolic control of inflammation and immunity.

230 findings shed light on a novel mechanism for metabolic control of inflammation by regulating HMGB1 re

231 ydrate metabolism, CardioGlyco, to study the metabolic control of myocardial glycolysis and G6P level

232 channel, implicating the BAD-K(ATP) axis in metabolic control of neuronal excitation and seizure res

233 l pyruvate uptake as a critical node for the metabolic control of neurotransmission in hippocampal te

234 ed cells and represents a potential site for metabolic control of NO synthesis.

235 Adenosine is a determinant of metabolic control of organ function increasing oxygen su

236 lon(tau) genetic circadian rhythm disorders, metabolic control of PER2 stability, and how drugs that

237 Metabolic control of pH was the main factor governing va

238 nesis, and point to previously unappreciated metabolic control of plasticity in helper T cells.

239 cient mice are very similar, suggesting that metabolic control of PRX O-GlcNAcylation is crucial for

240 onal sciences underlying the nutritional and metabolic control of pubertal development, with a focus

241 The metabolic control of respiration is still poorly underst

242 cus on emerging principles of epigenomic and metabolic control of retinal gene regulation, with empha

243 ore, these findings reveal a new pathway for metabolic control of ROS production in vivo, while demon

244 Origins of abscisic acid (ABA)-mediated metabolic control of stomatal conductance have been sugg

245 Thus, metabolic control of T cell locomotion provides new oppo

246 last few years, a full understanding of the metabolic control of T-cell functions, particularly duri

247 These results suggest that metabolic control of T1D affects the functional characte

248 osis and reinforce the importance of careful metabolic control of the acidosis to prevent and manage

249 ains were used to examine the regulation and metabolic control of the Calvin-Benson-Bassham (CBB) red

250 ed to genome endoreduplication, evidence for metabolic control of the G(1)-S transition, surface anti

251 These findings may have implications for metabolic control of the many CaMKII-controlled and prot

252 and stimulatory influences may be aspects of metabolic control of the pathway and thus of glycoprotei

253 In the present study we found another metabolic control of the proteasome via cAMP-dependent p

254 However, our understanding of the metabolic control of the state and fate of progenitor ce

255 However, the metabolic control of these processes is not fully unders

256 The most compelling issue was the effect of metabolic control on both the development and progressio

257 AMP-dependent pathway and exerts significant metabolic control on the Neurospora circadian clock.

258 ween the hematopoietic organ and the central metabolic control organ of the host fly.

259 profile was not found to be associated with metabolic control other than a very moderate association

260 c regulatory circuit and implementing direct metabolic control over cell culture processes.

261 tive regulatory gene, suggesting a degree of metabolic control over this pathway.

262 s with age (P < 0.001), sex (P = 0.028), and metabolic control (P = 0.034).

263 otein kinase) family, has important roles in metabolic control, particularly in response to nutrient

264 The action of daf-18 in this metabolic control pathway suggests that mammalian PTEN m

265 etes duration, diabetic treatment pattern or metabolic control per se did not significantly impact th

266 during pregnancy with the aim of maintaining metabolic control (plasma phenylalanine < or =10 mg/dL [

267 As the metabolic control plateaued and causes of death have div

268 emonstrate that ethylmalonyl-CoA mutase is a metabolic control point in the EMC pathway, expanding ou

269 SCD1, therefore, appears to be an important metabolic control point, and inhibition of its expressio

270 s been an effective strategy for identifying metabolic control points.

271 with PKU is associated with lack of maternal metabolic control prior to or early in pregnancy.

272 Offspring of women who had metabolic control prior to pregnancy had a mean (SD) sco

273 This occurs because internalization of metabolic controls-produced when gains in redundancy of

274 t as a simple thioredoxin inhibitor but as a metabolic control protein.

275 orts fall short of replicating the exquisite metabolic control provided by native islets.

276 uggest a link between telomeric proteins and metabolic control, providing an additional mechanism by

277 thms of nutrient intake, energy balance, and metabolic control remain poorly defined.

278 Implementation of this metabolic control resulted in an oscillatory malonyl-CoA

279 Tri-level metabolic control results in saturated cells containing

280 Clinical outcome, metabolic control, severe hypoglycemia, kidney function,

281 evelop renal disease despite moderately good metabolic control, suggesting other risk factors may pla

282 In this metabolic control system, IELs modulate enteroendocrine

283 rnative sugars, such as fructose, circumvent metabolic control systems and exacerbate this phenotype.

284 tical representation for use in the study of metabolic control systems make this enzyme an ideal subj

285 These data indicate that the level of metabolic control that determines acyl chain flux betwee

286 pathways with two models of enzyme kinetics: metabolic control theory (MCT) and Michaelis-Menten satu

287 Along a common paradigm of metabolic control theory, it is hypothesized that a larg

288 s effect is consistent with predictions from metabolic control theory.

289 thway revealed that recycling was subject to metabolic control through the Rag GTPases Gtr1 and Gtr2,

290 signaling node linking nutrient sensing and metabolic control to cell fate.

291 te ploidy across species, linking whole-body metabolic control to endothermics and to thyroid functio

292 attempts at intensified insulin therapy for metabolic control) underwent solitary pancreas transplan

293 The improved metabolic control was associated with better health-rela

294 70% of the metabolic control was in the lipid assembly block of rea

295 In an attempt to highlight metabolic control, we explore genotypic differences in c

296 ndicators of proinflammatory activation, and metabolic control, were evaluated.

297 rvations in rodent models of food intake and metabolic control, where TLQP-21 shows activity.

298 ical input parameter is the desired level of metabolic control, which is the time-averaged BUN (BUNa)

299 an endogenous function of ghrelin that links metabolic control with higher brain functions and sugges

300 Laboratory tests showed that she had poor metabolic control, with 497 mg/dl fasting blood glucose