ライフサイエンスコーパス: metabolic effect

1 adipose-derived factors in relation to their metabolic effect.

2 ariatric procedures, induces weight loss and metabolic effects.

3 PAHSAs have beneficial metabolic effects.

4 olution of inflammation and exert beneficial metabolic effects.

5 ic probiotics also have immunomodulatory and metabolic effects.

6 ion can promote adiposity and its associated metabolic effects.

7 CK) exert important complementary beneficial metabolic effects.

8 a common anaerobe previously associated with metabolic effects.

9 nisms underlying atenolol-associated adverse metabolic effects.

10 al products), disregarding global downstream metabolic effects.

11 been extensively studied for its beneficial metabolic effects.

12 y be critical determinants of long-term host metabolic effects.

13 target of POPs and may mediate part of their metabolic effects.

14 attenuates these SHP-mediated epigenomic and metabolic effects.

15 of offspring, underscoring the long reach of metabolic effects.

16 for AKG-mediated exercise-induced beneficial metabolic effects.

17 D36 in fat absorption and to its pleiotropic metabolic effects.

18 y state in AT, which may lead to detrimental metabolic effects.

19 of intermittent fasting (IF) exert important metabolic effects.

20 owth suppressors, activating metastasis, and metabolic effects.

21 yglucose (FDG-PET) were used to assess tumor metabolic effects.

22 iological roles of adiponectin go beyond its metabolic effects.

23 roliferative effects, whereas FGF21 has only metabolic effects.

24 regional atrophy substantially reduced most metabolic effects.

25 ut weight loss, exercise results in positive metabolic effects.

26 G(s) triggered qualitatively similar in vivo metabolic effects.

27 n tomography scans were used to assess tumor metabolic effects.

28 ceptor blockers have demonstrated beneficial metabolic effects.

29 AMPK is an important mediator of leptin's metabolic effects.

30 ics, but limited data are available on their metabolic effects.

31 substantially different short-term endocrine/metabolic effects.

32 be considered alongside its weight loss and metabolic effects.

33 al role of kinases upstream of AMPK in these metabolic effects.

34 ant INSR protein, attenuating its beneficial metabolic effects.

35 Growth Factor 21 (FGF21) elicits an array of metabolic effects.

36 mechanisms by which PAHSAs exert beneficial metabolic effects.

37 namic diameter <=200 nm have similar adverse metabolic effects.

38 n in non-REM and REM sleep, independently of metabolic effects.

39 -pancreatic tissues as well as its composite metabolic effects across distinct tissues.

40 lling pathway can have an overall beneficial metabolic effect and suggest that PI3K inhibition could

41 ol (RSV) and SRT1720 (SRT) elicit beneficial metabolic effects and are postulated to ameliorate obesi

42 etoprolol displays favorable hemodynamic and metabolic effects and could improve outcome in patients

43 In vivo metabolic effects and foraging ecology explain most of t

44 tissue injury, in addition to its well-known metabolic effects and functions.

45 Psychological stress may have adverse metabolic effects and induce unhealthy behaviors, but th

46 Better understanding of vitamin D metabolic effects and the Wnt, frizzled, secreted frizzl

47 chanism of action of PCSK9 inhibitors, their metabolic effects, and clinical outcomes associated with

48 Bile acids (BAs) exert pleiotropic metabolic effects, and physicochemical properties of dif

49 ream effectors required for this EGFR-driven metabolic effect are largely unknown.

50 arable results, indicating that the observed metabolic effects are directly caused by the lack of Shp

51 , supporting the concept that its beneficial metabolic effects are due specifically to GOAT inhibitio

52 We demonstrate that these beneficial metabolic effects are due to enhanced signaling through

53 These metabolic effects are not observed upon infection with &

54 or a high-fat diet, demonstrating that these metabolic effects are the result of enhanced muscling.

55 Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that b

56 leanness would be associated with beneficial metabolic effects at older ages.

57 However, the speed and potency of NO's metabolic effects at physiological concentrations are in

58 s these FAs appear to exert their beneficial metabolic effects because of their actions in membranes.

59 In parallel with these beneficial metabolic effects, betaine supplementation robustly incr

60 To determine any differences in metabolic effects between MR and LR, this study compared

61 t physiological levels can induce beneficial metabolic effects but that this is accompanied by WPW sy

62 These agents mediate their deleterious metabolic effects by reducing insulin secretion and incr

63 At the molecular level, Id1 mediates its metabolic effects by regulating the expression levels of

64 (+) production and suggested that downstream metabolic effects by TH can post-translationally activat

65 Interestingly, essentially all beneficial metabolic effects caused by adipocyte barr2 deficiency a

66 s-evoked helplessness, to map regional brain metabolic effects caused by fluoxetine treatment.

67 n mice fed with a chow diet leads to similar metabolic effects caused by high-fat feeding.

68 with carvedilol had superior hemodynamic and metabolic effects compared with metoprolol CR/XL.

69 oss-sectional observations, yet with greater metabolic effects (correspondence 160% +/- 2%; R(2) = 0.

70 te (InsP3) in the nucleus, whereas insulin's metabolic effects did not depend on either of these even

71 rial complex 1, but they indicate that their metabolic effects differ depending on the stage of cellu

72 irisin as a serum factor that mediates these metabolic effects during progressive kidney injury by in

73 t, we did not observe clinically significant metabolic effects during the study.

74 ality and cerebrovascular events, as well as metabolic effects, extrapyramidal symptoms, falls, cogni

75 Metabolic effects following combination antiretroviral t

76 Insulin, in addition to its metabolic effects, has promitotic and antiapoptotic acti

77 ar-weight multimer associated with favorable metabolic effects (i.e. greater insulin sensitivity, red

78 insulin signalling, results in a beneficial metabolic effect in aged mice.

79 While it produced no major metabolic effects in chow-fed mice, increasing leucine i

80 cting GLP1R/GCGR dual agonist peptide exerts metabolic effects in diet-induced obese mice that are di

81 itors is complex, the understanding of their metabolic effects in HLRCC may lead to the development o

82 etary fibers, exhibit correlative beneficial metabolic effects in humans and rodents, including impro

83 ikewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetec

84 ted protein 2, a secreted adipocytokine with metabolic effects in liver.

85 he area of lipid metabolism, and we observed metabolic effects in macroH2A1 knockouts.

86 However, GPR30 had no significant metabolic effects in male mice fed the HFD and both sexe

87 entiation, pituitary hormone regulation, and metabolic effects in many organs.

88 abeled mensacarcin together with its unusual metabolic effects in melanoma cells provide evidence tha

89 agliflozin and Its Cardiovascular, Renal and Metabolic Effects in Patients With Diabetes Mellitus, or

90 Its long-term metabolic effects in patients with T2DM are, however, un

91 FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long d

92 Insulin's metabolic effects in the liver are widely appreciated, b

93 nd peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasi

94 el mechanism that may explain its beneficial metabolic effects in type 2 diabetes patients.

95 use model of T-cell lymphoma and examine the metabolic effects in vitro.

96 ate that RSV and SRT do not induce analogous metabolic effects in vivo.

97 o nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion

98 nhanced ARH neural projections and long-term metabolic effects, including increased body weight, visc

99 To determine if the AAPs have detrimental metabolic effects independent of weight gain or psychiat

100 urs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a paralle

101 Hepatic and metabolic effects induced by dietary fat and cholesterol

102 nto the mechanisms underlying the beneficial metabolic effects induced by VSG.

103 Rather, the activation is partly linked to metabolic effects involving redox signaling.

104 This metabolic effect is both necessary and sufficient to ind

105 However, this metabolic effect is not translated into an attenuated ri

106 eshold required to exert clinically relevant metabolic effects is unknown.This study aimed to determi

107 changes were aggregated in the quantitative metabolic effect level index (MELI), allowing effect est

108 man MSCs with NPIs demonstrated a beneficial metabolic effect likely as a result of earlier islet vas

109 ification revealed further subgroup-specific metabolic effects limited to APOE epsilon4+ females.

110 ive nature of the disease and its consequent metabolic effects make this an attractive option for man

111 irect anti-apoptotic activity and beneficial metabolic effects, make HNG and SHLP2 exciting prospects

112 prising finding suggests that the pronounced metabolic effects mediated by activation of hepatic vaga

113 both virologically effective and has minimum metabolic effects, minimisation of traditional risk fact

114 e of modern regimens, which might have fewer metabolic effects, minimises the risk of myocardial infa

115 ific siRNA targeting FoxO1 recapitulates the metabolic effects observed in trained mice.

116 Thus, miRNAs contribute to the metabolic effects observed upon loss of TSC1 and hyperac

117 NAD(+) synthesis, explaining the overlapping metabolic effects observed with the two compounds.

118 We confirm the metabolic effects obtained with PX-478 treatment using a

119 etabolic study demonstrates that major lipid metabolic effects occur after replacing FO with VO in sa

120 We aim to determine the metabolic effect of a functional knockdown of TCF7L2 by

121 to determine the involvement of FGF21 in the metabolic effect of AHR.

122 hese rGBM patients strongly suggest a direct metabolic effect of cediranib and might also reflect an

123 rough elevated citrate levels or a secondary metabolic effect of citrate accumulation, and responds b

124 Increased energy expenditure is a primary metabolic effect of dietary protein restriction, and req

125 Accordingly, no direct metabolic effect of hydrogen sulfide is observed in larg

126 The pleiotropic metabolic effect of loss-of-function mutations in MRAP2

127 important implications for understanding the metabolic effect of OxLDL on the vessel wall and mechani

128 This points to a complex metabolic effect of RYGB that exceeds glucose normalizat

129 This metabolic effect of Zaprinast does not depend on inhibit

130 ate carrier in retina does not attenuate the metabolic effect of Zaprinast.

131 ERalpha completely attenuates the beneficial metabolic effects of 17alpha-E2 in male mice.

132 Thus, we studied the metabolic effects of a 12-month vitamin D supplementatio

133 es including type 1 diabetes, the underlying metabolic effects of a genetically altered immune system

134 Here, we explored the metabolic effects of a sEH inhibitor (t-TUCB) in fat-1 m

135 The metabolic effects of adipocyte-specific knockout of Cx43

136 The metabolic effects of adiponectin are mediated by adipone

137 xp3creInsrfl/fl mice were protected from the metabolic effects of aging, but surprisingly had reduced

138 Although the known metabolic effects of AMPK activation are consistent with

139 differentiation was independent of the known metabolic effects of AMPK, including glucose consumption

140 ce to beta cells and relief from the adverse metabolic effects of an inflammatory state in insulin-se

141 Inhibition of NADP synthesis rescues the metabolic effects of AOX1 KD.

142 Although the longer-term metabolic effects of ART exposure in the context of chil

143 We hypothesized that the specific metabolic effects of bacteriostatic and bactericidal ant

144 tomy may act as a bias in assessments of the metabolic effects of bariatric surgeries and their relat

145 As the metabolic effects of bariatric surgery are better elucid

146 ) and carbohydrate oxidation and opposes the metabolic effects of beta-adrenergic stimulation.

147 patic insulin signaling, suggesting that the metabolic effects of beta-catenin occurred via a paralle

148 owever, recent animal studies suggest direct metabolic effects of BNP.

149 e liposomes largely abolished the beneficial metabolic effects of calcipotriol, confirming that VDR a

150 tuin 1 (Sirt1), a mediator of the beneficial metabolic effects of calorie restriction, protects neuro

151 ptin resistance; however, the behavioral and metabolic effects of chronic AgRP neuronal hyperactivity

152 It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweete

153 These metabolic effects of cisplatin are abolished by pre-trea

154 expression of SQOR, further proving that the metabolic effects of CoQ10 supplementation are mediated

155 We hypothesized that the major metabolic effects of corticosteroids are mediated by cha

156 To understand better the metabolic effects of cyanide and to discover novel cyani

157 The metabolic effects of cyanide observed in zebrafish were

158 ts in the dairy matrix, which may modify the metabolic effects of dairy consumption.

159 isted in KO animals in which the confounding metabolic effects of diabetes were eliminated by islet t

160 signaling in the brain is necessary for the metabolic effects of dietary protein restriction and has

161 g approach is informative for predicting the metabolic effects of either an altered level of incident

162 ithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma.

163 ssue plays an integral role in mediating the metabolic effects of EPO.

164 esity are protected from many of the adverse metabolic effects of excess body fat and are considered

165 lycogen stores could exacerbate the negative metabolic effects of excessive fructose intake.

166 ve study evaluated the safety, efficacy, and metabolic effects of exenatide in subjects with type 1 d

167 actors associated with obesity/diabetes, the metabolic effects of exercise on the heart are not well-

168 y induction may contribute to the beneficial metabolic effects of exercise.

169 does not play a role in mediating favorable metabolic effects of FGF21 administration in DIOs housed

170 orie is just a calorie" and suggest that the metabolic effects of food may matter as much as its ener

171 The combined cerebral metabolic effects of galantamine and citalopram suggest,

172 nisms as well as their impact on the overall metabolic effects of GBP surgery.

173 limited data are available on the potential metabolic effects of GDF11 or GDF8 in aging.

174 RAL with a monoclonal antibody prevented the metabolic effects of GDF15 in rats.

175 and as the bona fide receptor mediating the metabolic effects of GDF15, enabling a more comprehensiv

176 AL is a receptor for GDF15 that mediates the metabolic effects of GDF15.

177 or at local sites of GH action, whereas the metabolic effects of GH are considered to be intrinsic t

178 To study the direct metabolic effects of GH in the muscle, we specifically i

179 otypes and molecular pathways regulating the metabolic effects of GH on adipose tissue.

180 he present study we compared the feeding and metabolic effects of ghrelin and NPY following pretreatm

181 igate whether the growth hormone release and metabolic effects of ghrelin on AMPK activity of periphe

182 Our data suggest that the metabolic effects of ghrelin on AMPK in peripheral tissu

183 metabolism and cell death by evaluating the metabolic effects of glucose deprivation on mouse photor

184 rs' diets, and 3) the latest research on the metabolic effects of HFCS.

185 e objective of this study was to examine the metabolic effects of high-dose resveratrol in obese huma

186 These studies indicate that, unlike the metabolic effects of highly restricted neuronal subsets

187 Given the opposing metabolic effects of hypoxia and diabetes, we questioned

188 et addressed whether it can also prevent the metabolic effects of ICP in the offspring and fetoplacen

189 Nevertheless, the metabolic effects of increasing eNOS levels have not bee

190 eem to be major mediators of the detrimental metabolic effects of insufficient sleep, through favouri

191 IR-B promotes the metabolic effects of insulin, whereas IR-A rather signal

192 /AKT pathway, is hypothesized to inhibit the metabolic effects of insulin.

193 Aeration limitation not only obscured the metabolic effects of iron limitation but also overrode t

194 The aim of the study was to assess long-term metabolic effects of laparoscopic sleeve gastrectomy (LS

195 ach component in mediating the anorectic and metabolic effects of leptin, and in regulating the parti

196 individual carotenoids, possibly reflecting metabolic effects of lifestyle and physiologic factors o

197 nd there is a paucity of data describing the metabolic effects of light on environmental photoheterot

198 e CAMELLIA-TIMI 61 trial (Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese

199 Although a few metabolic effects of metformin and the related biguanide

200 most current evidence for liver-specific and metabolic effects of microbiome-targeted therapies (MTTs

201 , MLYCD, is experimentally validated and the metabolic effects of MLYCD depletion investigated.

202 s MAO people are predisposed, to the adverse metabolic effects of moderate weight gain and that incre

203 Mechanistically, the salutary metabolic effects of nitrate and nitrite can be ascribed

204 Metabolic effects of NLRX1 deficiency are observed in a

205 cose and cholesterol metabolism and that the metabolic effects of Nnmt in the liver are mediated by i

206 To this end, we set out to investigate the metabolic effects of NO in cultured astrocytes from mice

207 Furthermore, it showed that metabolic effects of noise on the inner ear depend on th

208 on were monitored to determine the immediate metabolic effects of nuclear stains, including SYTO, DAP

209 The metabolic effects of omega-6 polyunsaturated fatty acids

210 Whereas these metabolic effects of oncogenic KRAS have been explained

211 However, the underlying metabolic effects of opioid withdrawal and replacement h

212 The metabolic effects of OXM have been attributed primarily

213 and IGFBP-4, thereby explaining the distinct metabolic effects of prednisolone and infliximab.

214 The adverse metabolic effects of prescribed and endogenous glucocort

215 ling pathways in the brain contribute to the metabolic effects of PTP1B deficiency remains unclear.

216 B signaling may contribute to the beneficial metabolic effects of PTP1B deficiency.

217 The metabolic effects of RA or RARbeta are mimicked by FGF21

218 , thereby enabling in vivo monitoring of the metabolic effects of reperfusion strategies.

219 pathway that is essential for the beneficial metabolic effects of resistance exercise in mice.

220 PKalpha1 or -alpha2 to determine whether the metabolic effects of resveratrol are mediated by AMPK.

221 Here, we report that the metabolic effects of resveratrol result from competitive

222 f resveratrol, is the central target for the metabolic effects of resveratrol.

223 e, we investigated in a Rhcg mouse model the metabolic effects of Rhcg haploinsufficiency, the role o

224 gnificantly associated with the hormonal and metabolic effects of RS.

225 results question previous findings of unique metabolic effects of RYGB and suggest that the effect of

226 -HSD1-deficient mice were resistant to these metabolic effects of salicylate.

227 ular mechanisms involved in these beneficial metabolic effects of salsalate by treating mice with sal

228 In order to determine the metabolic effects of selenide administration, we exposed

229 We also examined the metabolic effects of selenide administration.

230 he distal small bowel mucosa may explain the metabolic effects of SG occurring before substantial wei

231 tituted with activation-defective SIRT1, the metabolic effects of STACs were blocked.

232 tein turnover, but little is known about the metabolic effects of stretch.

233 biota compositions and the physiological and metabolic effects of TCDF.

234 The early metabolic effects of the anti-HER2 therapies on the prim

235 Here, we examined the physiological and metabolic effects of the deficiency of these two bile ac

236 When metabolic effects of the knockout are impaired, NLRX1-de

237 Feeding and metabolic effects of the MC-R agonist melanotan II (MTII

238 estion is unclear.We sought to determine the metabolic effects of the pharmacologic inhibition of STR

239 ew we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the

240 iology of myotoxicity most probably involves metabolic effects of the statins on the isoprenoid pool

241 Bariatric or metabolic effects of the surgical procedures appear inde

242 The metabolic effects of the treatment are not attributed to

243 The metabolic effects of the two interventions differed in t

244 C-1alpha in skeletal muscle for the systemic metabolic effects of these compounds has so far not been

245 I is uniquely suited to directly measure the metabolic effects of these emerging treatments.PurposeTo

246 xamined this notion using PET to compare the metabolic effects of these treatment approaches.

247 To determine the metabolic effects of these two ligands, we administered

248 The metabolic effects of these two peptides with respect to

249 findings provide a mechanism for integrating metabolic effects of THs with the tumor suppressor activ

250 These studies reveal for the first time the metabolic effects of tissue-specific increases in NAD sy

251 "beiging" of WAT, regulation of adipokines, metabolic effects of trained adipose tissue on systemic

252 ted into recipient mice further improved the metabolic effects of transplantation.

253 synthesis of other stress effectors, or the metabolic effects of trehalose biosynthetic intermediate

254 thioredoxin, and it is not known whether the metabolic effects of Txnip are related to its ability to

255 Recently, the deleterious metabolic effects of visceral fat [visceral adipose tiss

256 obese" (MAO), are protected from the adverse metabolic effects of weight gain.

257 Intervention studies have indicated that the metabolic effects of whole dairy may be different than t

258 With these metabolic effects, oleate also supported a 25% improveme

259 isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism an

260 oxide synthase 2 (NOS2)]- indicating minimal metabolic effect on the cysH mutant survival in these mi

261 t that AICAR induces profound cytostatic and metabolic effects on 1CT+7 cells, but not on their isoge

262 l sweeteners have previously uncharacterized metabolic effects on adipocyte differentiation and metab

263 modulating bile acid levels, and additional metabolic effects on glucose metabolism, nonalcoholic li

264 AKT/mTOR metabolic effects on hepatocytes, after insulin stimulat

265 ct the outcome of parasitic diseases through metabolic effects on host immunity and/or the parasite.

266 However, whether BDNF exerts metabolic effects on peripheral organs is currently unkn

267 substantial physiological, immunological and metabolic effects on these athletes.

268 lta(13)C while changes in extension rate and metabolic effects over time modulate skeletal delta(13)C

269 Moreover, these metabolic effects, particularly an increase in fatty aci

270 In addition to metabolic effects, PMA treatment also translocated PKM2,

271 en linked to both beneficial and deleterious metabolic effects, potentially confounded by diverse det

272 Beyond these metabolic effects, PPARgamma agonists exhibit antineopla

273 Most metabolic effects regulated by FXR in mouse and human li

274 n homozygosis: Deltay A set of molecular and metabolic effects, reminiscent of those observed in the

275 These beneficial metabolic effects required the activity of SKM AMPK.

276 actions appear to be independent of leptin's metabolic effects.SIGNIFICANCE STATEMENT Sexual maturati

277 and the entorhinal cortex showed the largest metabolic effect size.

278 Metabolic effect sizes were determined with and without

279 f this class, has been shown to have several metabolic effects such as reducing weight gain and visce

280 Antiretroviral agents associated with fewer metabolic effects, such as tenofovir and abacavir, remai

281 had experienced comparable or more favorable metabolic effects than those assigned to the Zone, Ornis

282 hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global altera

283 summary, aldosterone excess has detrimental metabolic effects that contribute to the metabolic syndr

284 T in human beings could also have beneficial metabolic effects that might resolve common complication

285 c studies suggest that sleep restriction has metabolic effects that predispose to weight gain.

286 of the Western 'fast-food' diet, have unique metabolic effects that suggest they may be key contribut

287 silencing of Opa-1 or Mfn2 prevented all the metabolic effects triggered by insulin.

288 These adducts may exert metabolic effects unrelated to their effect on gluconeog

289 n methyl-pool homeostasis and determined its metabolic effects using the methionine and choline-defic

290 that olanzapine exerts some of its untoward metabolic effects via antagonism of HTR2C.

291 ng the distinctive features of buprenorphine metabolic effects vis-a-vis those of methadone and their

292 The metabolic effect was also negated by coinfusion with tet

293 rown adipose tissue and to elicit beneficial metabolic effects was blunted.

294 These beneficial metabolic effects were accompanied by the enhanced expre

295 Similar metabolic effects were also evident, albeit in the absen

296 Changes in metabolic effects were assessed following cART in the AI

297 ffect, and notably these pro-survival versus metabolic effects were dissociable to a significant exte

298 se compounds both in vivo and in vitro These metabolic effects were minimized in the presence of two

299 Hepatocellular damage, inflammation, and metabolic effects were quantified by enzyme activities,

300 Berry intake has overall metabolic effects, which depend on the cardiometabolic r