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1 y in which CO is produced and then used as a metabolic intermediate.
2 esources into offspring that are mediated by metabolic intermediates.
3 here were corresponding changes in polyamine metabolic intermediates.
4 n mucosal surfaces through the production of metabolic intermediates.
5 armaceuticals, and also represent endogenous metabolic intermediates.
6 and, in some cases, to small phosphorylated metabolic intermediates.
7 ing complex and signalling lipid species and metabolic intermediates.
8 sion of ferroptosis, and biosynthesis of key metabolic intermediates.
9 acid, serotonin, histamine, amino acids, and metabolic intermediates.
10 regulation and is sensitive to the levels of metabolic intermediates.
11 a central role in cellular physiology as key metabolic intermediates.
12 ical pathways by confining toxic or volatile metabolic intermediates.
13 ases, producing xylosyl-xylitol oligomers as metabolic intermediates.
14 proteins and lipids via generation of toxic metabolic intermediates.
15 ells, resulting in the accumulation of cycle metabolic intermediates.
16 enes can explain the decreases in associated metabolic intermediates.
17 3-oxo-4-cholestenoic acid, one of the first metabolic intermediates.
18 (CoAs) are critical regulatory molecules and metabolic intermediates.
19 umulated sugar-phosphates or to depletion of metabolic intermediates.
20 th amino acids for protein synthesis and for metabolic intermediates.
21 f secondary metabolic pathways by binding to metabolic intermediates.
22 protection against the accumulation of toxic metabolic intermediates.
23 f the flavonoid pathway and utilize the same metabolic intermediates.
24 ich necessitates multiple steps to transport metabolic intermediates.
26 ention in trypanosomatid protozoa to the key metabolic intermediate 5,10-CH(2)-THF, situated at the j
27 Feeding with excess l-DOPA showed that the metabolic intermediate 5,6-dihydroxyindole reached the h
28 hway for tryptophan degradation, an unstable metabolic intermediate, a-amino-B-carboxymuconate-e-semi
29 m a key pathway for synthesis of the central metabolic intermediate acetyl coenzyme A (acetyl-CoA) fr
31 de chain of biotin, also produce the crucial metabolic intermediates acetyl-CoA and butyryl-CoA with
32 ism have led to the hypothesis that neuronal metabolic intermediates affect neural outputs that modif
33 expression in vSMCs treated with BaP or its metabolic intermediates alone, and in combination with a
34 hway for tryptophan degradation, an unstable metabolic intermediate, alpha-amino-beta-carboxymuconate
35 stids, and also report copolymer production, metabolic intermediate analyses, and pathway dynamics.
40 ing reductive carboxylation steps to produce metabolic intermediates and compounds found in meteorite
41 educed from the redistribution of label into metabolic intermediates and end products observed when c
42 duced from the redistribution of (13) C into metabolic intermediates and end products when cells were
43 ombined with intercellular communication via metabolic intermediates and fluid dynamics of the reacti
44 mn produced relatively low concentrations of metabolic intermediates and had a greater proportion of
45 is most probably involves both production of metabolic intermediates and modulation of erythropoietin
46 and reveals crosstalk between light-induced metabolic intermediates and photoreceptor-mediated devel
47 microbiology are revealing the importance of metabolic intermediates and reactions that can lead to t
48 etabolism through not only the production of metabolic intermediates and reductive NADPH but also inh
49 in which the inherent chemical reactivity of metabolic intermediates and substrates evades the involv
50 These changes are brought about by several metabolic intermediates and their corresponding sensor p
51 adioactivity from 14C-labeled compounds into metabolic intermediates and total lipids was examined in
52 unique enzymes by nutrient availability and metabolic intermediates, and describe these properties i
53 Here, we explore how steady state levels of metabolic intermediates are altered in brown adipose tis
56 of metabolic pathways or the accumulation of metabolic intermediates as a consequence of environmenta
60 echniques to identify diphosphate-containing metabolic intermediates at submillimolar concentrations
62 enzymes required to convert PCP to a common metabolic intermediate before entering the tricarboxylic
63 nstrated clear differences in the pattern of metabolic intermediates between amelanotic and melanotic
64 specific transport systems translocating the metabolic intermediates between these two compartments h
65 oid bases and their 1-phosphate are not only metabolic intermediates but also highly bioactive lipids
66 y is gut microbiota-dependent synthesis of a metabolic intermediate called TMA, and subsequent host-d
67 vity measurements, we show that a downstream metabolic intermediate can selectively remove the cataly
69 In Saccharomyces cerevisiae, the classic metabolic intermediate co-enzyme A (CoA) serves as an en
70 sterically preclude formation of a putative metabolic intermediate complex to deliver advanced TRPV4
71 r, including mechanism-based inactivation by metabolic-intermediate complex formation, competitive in
72 l hydroxylases, circadian clock proteins and metabolic intermediates control the activities of HIF1 a
73 ar anaerobic by-products and regenerate many metabolic intermediates depleted in metabolic depression
74 th the fact that succinate is generated as a metabolic intermediate during cellular respiration, have
76 alytical approaches, capture a hydroxylamino metabolic intermediate en route to 6-nitronorleucine for
80 tic plastids the OPPP produces reductant and metabolic intermediates for central biosynthetic process
81 uire accurate isotopic data of intracellular metabolic intermediates for stationary, nonstationary, a
83 These observations fit a model in which the metabolic intermediate formaldehyde is required for net
86 he infusion transfers the isotope label into metabolic intermediates from pathways supplied by the in
90 entification of the related enzyme genes and metabolic intermediates generated during the metabolic p
91 fatty acids (BCFAs), amino acids, and other metabolic intermediates generated from acyl-coenzyme A,
93 ooA were important in the cycling of CO as a metabolic intermediate, global transcriptional analyses
95 signaling pathways through the production of metabolic intermediates has been increasingly noted.
96 kinase isoform (PKM2) reduces the levels of metabolic intermediates important for biosynthesis and i
97 e ability to initiate the synthesis of a key metabolic intermediate in an allosterically regulated fa
100 hether measurement of concentrations of this metabolic intermediate in plasma could provide a new met
101 rs that respond to farnesyl pyrophosphate, a metabolic intermediate in the production of valuable com
102 phosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol,
103 ince trans-aconitate does not appear to be a metabolic intermediate in these cells but forms spontane
109 f vitamin A (all-trans-retinol) and serve as metabolic intermediates in the formation of the visual c
110 Pim occurred as a result of lower levels of metabolic intermediates in the glycolytic and pentose ph
111 applied targeted metabolomics to measure the metabolic intermediates in the most relevant pathways fo
113 rincipally by the adenine nucleotides, other metabolic intermediates, including long chain acyl-CoA e
114 ting fatty acids to acyl-CoAs and downstream metabolic intermediates increases cellular fatty acid up
115 study demonstrates that the known tryptophan metabolic-intermediate indole-3-pyruvate is a proagonist
116 Here, we show that lactate, an important metabolic intermediate, induces browning of murine white
118 s the flow of glucose- and glutamine-derived metabolic intermediates into the Tricarboxylic Acid (TCA
120 as distinct structures compartmentalizing a metabolic intermediate involved in regeneration of the v
122 ly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulatio
123 of <2 s at 100 degrees C, yet this critical metabolic intermediate is found even in organisms that g
124 of defensive compounds are derived from the metabolic intermediate, isopentenyl diphosphate (IPP).
125 to regenerate NAD from NADH by reducing the metabolic intermediate L-lactaldehyde to propanediol whi
126 Interestingly, ZMYND8-induced changes in metabolic intermediate lactate in breast cancer cells, a
127 ough this pathway is negatively regulated by metabolic intermediates, little is known of the metaboli
129 ysregulated production of growth factors and metabolic intermediates occurs, promoting retinal angiog
130 iscover that farnesyl pyrophosphate (FPP), a metabolic intermediate of the MVA pathway, functions as
131 g precise detection of isotopologues in most metabolic intermediates of central carbon metabolism.
133 t is lost during catalysis in a pathway with metabolic intermediates of metal-chelating properties.
134 stribution, characteristic peaks of C=O, and metabolic intermediates of residual polymers in egested
137 derangement of many signaling molecules and metabolic intermediates; of these, the massively increas
138 athway (WLP) is unique in generating CO as a metabolic intermediate, operating through organometallic
139 l fate commitment through the utilization of metabolic intermediates or end products of metabolic pat
140 ationship between the two species in which a metabolic intermediate produced by E. coli was used and
142 steps in the pathway that yield the central metabolic intermediates pyruvate and propionyl coenzyme
143 involves the sequestration of sirohaem as a metabolic intermediate rather than as a prosthetic group
144 progression is believed to involve reactive metabolic intermediates reacting with constituents of Br
145 method employs two-photon excitation of the metabolic intermediate, reduced nicotinamide adenine din
146 ng the production of mitochondrial-dependent metabolic intermediates required for cell growth, and th
147 es of M. tuberculosis specifically generates metabolic intermediates reserved for re-initiation of pe
148 s fungal pathogen to synthesize the critical metabolic intermediate S-adenosylmethionine and work by
149 s of organic matter into a wealth of smaller metabolic intermediates, some of which are released to t
150 res were treated with trichodiene, the first metabolic intermediate specific to the trichothecene bio
151 e elasticity in permitted pool sizes for key metabolic intermediates such as pyruvate and acetyl-CoA.
153 otein, chlorophyll), total phenols and major metabolic intermediates (sugars, starch, nitrate, amino
156 -chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays important cellular reg
158 tamine feed into amastigote sterols and into metabolic intermediates that accumulate upon CYP51 inhib
159 bolism in order to limit levels of dangerous metabolic intermediates that can interfere with essentia
160 f protoheme (heme) uses a common set of core metabolic intermediates that includes protoporphyrin.
161 of the CNS monitor and respond to levels of metabolic intermediates that reflect peripheral energy s
162 need to reduce the build-up of thermolabile metabolic intermediates that would be susceptible to des
163 hough 2,6-dichlorohydroxyquinol is a logical metabolic intermediate, the enzyme hardly uses it as a s
164 and chemicals are generated from short-chain metabolic intermediates through pathways that require ca
165 ine, and they actively synthesize and export metabolic intermediates to the apical side to nourish th
166 ustness of the biocatalysts that convert the metabolic intermediates to, in some cases, finished and
167 we demonstrate by mass spectrometry that the metabolic intermediates UDP-GalNGc and UDP-GlcNGc serve
168 atic synthesis of phosphorylated high-energy metabolic intermediates under conditions considered to h
170 ncy of cholesterol and accumulation of toxic metabolic intermediates, we assessed the efficacy of com
173 ctions as a signaling hub, producing several metabolic intermediates which serve roles in both signal
175 ely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vecto
177 TMs) serve as pivotal mechanisms integrating metabolic intermediates with immune signaling pathways.
179 mn generated periodic high concentrations of metabolic intermediates, with Bacteria and methanogens d