ライフサイエンスコーパス: metabolic pathway

1 t glucose production, a PGC-1alpha-regulated metabolic pathway.

2 uggesting that PEN2 and PCS1 act in the same metabolic pathway.

3 RAF3 in B cells are clustered in the choline metabolic pathway.

4 m brevicompactum NRRL 864 and elucidated the metabolic pathway.

5 tion of quinolinic acid at a junction of the metabolic pathway.

6 , pushing material through the dysfunctional metabolic pathway.

7 nsitizing them to perturbations of connected metabolic pathways.

8 nd pentose phosphate pathway (PPP) branching metabolic pathways.

9 vide fertile ground for the evolution of new metabolic pathways.

10 ore and after meal intake, and for different metabolic pathways.

11 bolic profile with broad changes in multiple metabolic pathways.

12 in prokaryotes, regulates various microbial metabolic pathways.

13 lipogenic signaling and suppression of lipid metabolic pathways.

14 n exclusive food source through pre-existing metabolic pathways.

15 f feijoa fruit was associated with five main metabolic pathways.

16 regulate the expression of key components of metabolic pathways.

17 ed trans-eQTL hotspots spanning a variety of metabolic pathways.

18 roperties correlate significantly with known metabolic pathways.

19 ors to multiple homeostatic, regulatory, and metabolic pathways.

20 various organisms do so by targeting central metabolic pathways.

21 nted unique alterations in mitochondrial and metabolic pathways.

22 cell to compensate for incomplete bacterial metabolic pathways.

23 and present data in the context of annotated metabolic pathways.

24 ion of genes involved in regulating multiple metabolic pathways.

25 uta there was higher abundance of fatty acid metabolic pathways.

26 sition and extracellular matrix, and reduced metabolic pathways.

27 uch amino acids are generated in specialized metabolic pathways.

28 making it the largest curated collection of metabolic pathways.

29 hormones and alter synthesis, transport, or metabolic pathways.

30 transcription of genes involved in multiple metabolic pathways.

31 nt industrial compounds that disrupt various metabolic pathways.

32 oss of the conserved hnRNP RALY enriches for metabolic pathways.

33 stem cells (ISCs) are regulated by diet and metabolic pathways.

34 iverse specialized metabolites via multistep metabolic pathways.

35 of genetic risk factors for AD and aberrant metabolic pathways.

36 l framework by coupling gene regulation with metabolic pathways.

37 applied because they feed a large number of metabolic pathways.

38 es in regulating a variety of signalling and metabolic pathways.

39 nitiation and degradation of target mRNAs in metabolic pathways.

40 availability to intracellular signaling and metabolic pathways.

41 gene duplication events in the evolution of metabolic pathways.

42 eactions in a variety of anaerobic microbial metabolic pathways.

43 M and cell-cell adhesion complexes influence metabolic pathways.

44 and the possible interplay between the 2 Trp metabolic pathways.

45 ffect sizes and stringent PICRUSt2 predicted metabolic pathways.

46 ce proteins, transcriptional regulators, and metabolic pathways.

47 ion of key genes involved in ABA and sucrose metabolic pathways.

48 metabolic models toward the discovery of key metabolic pathways.

49 al potential and taxon-level associations in metabolic pathways.

50 ture, bacterial SLs are processed by host SL-metabolic pathways.

51 PPI) is an attractive way to affect multiple metabolic pathways.

52 panded to engineer other microbial cells and metabolic pathways.

53 ticularly potent in detecting alterations in metabolic pathways.

54 c diseases to identify possible contributing metabolic pathways.

55 drial dysfunction and significant changes in metabolic pathways accompany cancer development and are

56 fic (ETSP) ODZ, indicating arsenotrophy is a metabolic pathway actively utilized in anoxic marine wat

57 g (scMEP), quantifies proteins that regulate metabolic pathway activity using high-dimensional antibo

58 IPTiDe correctly identifies context-specific metabolic pathway activity without supervision or knowle

59 cle arrested or 'stumpy' form that activates metabolic pathways advantageous to the parasite in the i

60 Thus, primordial metabolic pathways, already present in bacteria before a

61 In our analysis, ALS led to significant metabolic pathway alterations, which had correlations to

62 In summary, we reveal an essential metabolic pathway amenable to targeting in NSCLC.

63 Among the various modeling approaches, metabolic pathway analysis can dissect the basic functio

64 Secondly, predictive metabolic pathway analysis using the 16S rRNA gene data

65 h, Blast, synteny view, enrichment analysis, metabolic pathway analysis, a genome browser, etc.

66 We further elucidate the likely metabolic pathway and CYP isoforms responsible for DHD1

67 lysis revealed alterations in the pyrimidine metabolic pathway and cytidine deaminase (CDA).

68 that occurred in genes involved in this key metabolic pathway and that could explain the phenotypes

69 ll energy homeostasis, the choice of a given metabolic pathway and the levels of particular substrate

70 tic conditions that can disrupt intermediary metabolic pathways and cause defective absorption and me

71 hreonine phosphatase that regulates multiple metabolic pathways and contributes to tumorigenesis in a

72 ailed MCR/ACR-based phylogeny, compare their metabolic pathways and discuss the gaps in our knowledge

73 rough efferocytosis by macrophages can alter metabolic pathways and downstream function of the effero

74 rg) is a comprehensive reference database of metabolic pathways and enzymes from all domains of life.

75 umer preference and determined by underlying metabolic pathways and gene expression.

76 red to access unforeseen routes of improving metabolic pathways and product yields.

77 QTL harboring genes (eGenes) are enriched in metabolic pathways and tend to have higher SNP heritabil

78 ceptible tetrad stage strongly affects basic metabolic pathways and thus generates germination-defect

79 Finally, we discuss the effects of aging on metabolic pathways and we show how metabolic complicatio

80 tics, proteostasis, cell surface structures, metabolic pathways, and adaptation to high salt environm

81 that can lead to the discovery of molecules, metabolic pathways, and ecosystem/community interactions

82 nalling, inflammatory homoeostasis, cellular metabolic pathways, and mitochondrial function.

83 measured are generally members of well-known metabolic pathways, and most of them can be detected usi

84 to terrestrial life involved innovations in metabolic pathways, and reveal the molecular mechanisms

85 ident memory T cells, manipulation of T cell metabolic pathways, and the latest promising approaches

86 lammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals.

87 nces in metabolomics illustrate that various metabolic pathways are also important in regulating stem

88 Overall, we demonstrate that specific lipid metabolic pathways are coherently altered when hepatocyt

89 vels of enzymes in the glucose and glutamine metabolic pathways are elevated in Tregs and Bregs of th

90 These metabolic pathways are induced during infection by the p

91 ve further examined how the KSHV-reprogramed metabolic pathways are regulated and discovered that KSH

92 plexes consisting of sequential enzymes of a metabolic pathway, are proposed to be biosynthetic "hots

93 scale genome engineering and the rewiring of metabolic pathways, are highlighted.

94 Multiple immune receptor types rewire metabolic pathways as a key part of how they promote eff

95 Our data show dysregulated metabolic pathways as important contributors to AMD path

96 Increasing evidence implicates metabolic pathways as key regulators of cell fate and fu

97 ial of interfering with osteoclast-intrinsic metabolic pathways as possible strategy for the treatmen

98 f metabolic intermediates or end products of metabolic pathways as substrates for enzymatic histone/D

99 o-culture with activated microglia disturbed metabolic pathways, as indicated by unbiased transcripto

100 To identify metabolic pathways associated with aging, we analyzed ag

101 on-targeted metabolomics profiling to reveal metabolic pathways associated with higher VAT or SAT amo

102 nmental influences and allows elucidation of metabolic pathways associated with infant adiposity.

103 are able to extract known and new bacterial metabolic pathways associated with inflammatory bowel di

104 ify differentially expressed metabolites and metabolic pathways associated with neuropathology and co

105 ral SCFAs-producing gut bacteria, as well as metabolic pathways associated with SCFAs production, wer

106 lecules, we identified novel metabolites and metabolic pathways associated with serum electrolyte lev

107 n scores with serum metabolites and identify metabolic pathways associated with the metabolites.

108 Metabolic pathways at the host-microbe intersection will

109 excess fuel, the beta-cells possess specific metabolic pathways, but little is known about these path

110 amples of direct and rapid regulation of the metabolic pathways by the RAS-ERK pathway remain elusive

111 protein or on different proteins in the same metabolic pathway can interact to fine-tune metabolic re

112 fficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell

113 ost-translational modification cascades, and metabolic pathways can be described in principle by bioc

114 Gene signatures of oncogenic or metabolic pathways can further distinguish between the s

115 abolites in an organism, and, when linked to metabolic pathways, can provide a snapshot of an organis

116 gions (DMRs) were found in genes involved in metabolic pathways, carbon metabolism, and fatty acid me

117 ver, infected IECs reprogramme intracellular metabolic pathways, characterized by simultaneous activa

118 However, targeting metabolic pathways chronically and ubiquitously makes it

119 pable of correctly predicting the respective metabolic pathway class of 95.16% of tested compounds, w

120 Carnelian is able to find shared metabolic pathways, concordant functional dysbioses, and

121 hine learning (UML), we can discover unknown metabolic pathways connections and links on numerous bio

122 An engineered metabolic pathway consisting of reactions that convert f

123 hway identified in the KEGG database was the metabolic pathway containing 101,427 annotated genes, wh

124 Thus, if a metabolic pathway contains a toxic intermediate, then we

125 In addition, certain metabolic pathways continued to remain active during apo

126 We therefore sought to determine the metabolic pathways contributing to synthesis of essentia

127 ion by SIN3, we sought to identify genes and metabolic pathways controlled by SIN3 and SAM synthetase

128 Reprogramming metabolic pathways could improve the ability of metaboli

129 computational approach based on whole-genome metabolic pathway databases of eight species representat

130 g targets, efficient library construction of metabolic pathway designs, and high-throughput biosensor

131 s to test the feasibility of plant synthetic metabolic pathways despite gaps in the accumulated knowl

132 Inhibition of either the CDA or pyrimidine metabolic pathway diminished survival in MUC1-expressing

133 per insights into the effects of fluorine on metabolic pathways, distribution, and disposition.

134 uence many key cellular functions, including metabolic pathways, DNA repair, chromatin remodelling, c

135 Together, these examples suggest that metabolic pathways do not simply provide the fuel that p

136 The essential roles of the metabolic pathway during soybean nodulation were further

137 dis, S capitis, S aureus), and enrichment in metabolic pathways (eg, branched chain amino acids and a

138 The metabolic pathways encoded by the human gut microbiome c

139 The NGF metabolic pathway entails the proteins that mature pro-n

140 We revealed the presence of a putative metabolic pathway for histamine degradation.

141 define cholesterol metabolism as an integral metabolic pathway for the optimal functioning of human I

142 The major metabolic pathways for biomass growth or for biosynthesi

143 While the metabolic pathways for PAE degradation have been establi

144 for fast and flexible design of heterologous metabolic pathways for plastid metabolic engineering.

145 target cellular bactericidal and homeostatic metabolic pathways for successful bacterial persistence.

146 oupled receptor) signalling pathway; and the metabolic pathways for vitamin D, oxalate, cysteine, pur

147 ing strategies can be utilized to transplant metabolic pathway from any origin into yeast.

148 Although the metabolic pathways generating eicosanoid-lysophospholipi

149 obial community and the presence of specific metabolic pathway genes contribute to the initiation and

150 Growing evidence demonstrates that metabolic pathways govern epigenetic regulation of gene

151 olism is a cancer vulnerability, and several metabolic pathways have been shown to promote PDAC.

152 Efforts to decipher the prebiotic roots of metabolic pathways have focused on recapitulating modern

153 ion, and reveal how classical definitions of metabolic pathways have overlapping functionality.

154 obacterium tuberculosis (Mtb), and therefore metabolic pathways have recently re-emerged as attractiv

155 l a previously unappreciated, tumor-specific metabolic pathway hijacked from one of the most ATP-inte

156 Moreover, two important metabolic pathways, i.e. benzoate degradation and phosph

157 response can be rapidly detected, while the metabolic pathways impacted provide information about th

158 Circadian (daily) regulation of metabolic pathways implies that food may be metabolized

159 l response either by down-regulating various metabolic pathways important for viral replication or by

160 ding the heterogeneous activation of a niche metabolic pathway in a subpopulation of cells.

161 purine metabolism as a novel host-microbial metabolic pathway in IBS with translational potential.

162 7M and mIDH1 hijack a conserved and critical metabolic pathway in opposing ways to maintain their pre

163 id biosynthesis as the most underrepresented metabolic pathway in patients who later acquire C. diffi

164 ws that estrogen 4-hydroxylation is the main metabolic pathway in the central nervous system.

165 dian clocks and metabolism with nearly every metabolic pathway in the mammalian liver under circadian

166 hic extent and taxonomic affiliation of this metabolic pathway in the ocean.

167 d differentiation, and the inhibition of key metabolic pathways in activated T cells represents a log

168 ased approach investigating arachidonic acid metabolic pathways in AERD.

169 ondrial lysine acetylation regulates several metabolic pathways in cardiac cells.

170 ynamic expression of TLR4 results in altered metabolic pathways in diabetic macrophages.

171 Genetic abolition of BA metabolic pathways in individual gut symbionts significa

172 a key player in controlling glucose-derived metabolic pathways in mammalian cells, themselves hijack

173 of nature's unlimited number of enzymes and metabolic pathways in microbial strains.

174 ents cerebral cortex expansion by regulating metabolic pathways in mitochondria.

175 P-associated genes were involved in numerous metabolic pathways in mothers and cubs, indicating that

176 ion is an effective strategy for fine-tuning metabolic pathways in order to maximize target product s

177 Tumors rewire metabolic pathways in response to stress signals such as

178 scuss the pro-longevity effects of targeting metabolic pathways in specific tissues and how these int

179 reductions in genes, microbial strains, and metabolic pathways in stressed dams that are primarily a

180 gher coverage of phosphonate and siderophore metabolic pathways in the star coral, Montastraea cavern

181 assist the dissection of the critical immune-metabolic pathways in this complex disease.

182 To define metabolic pathways in which AHR cooperates with MYC in s

183 of multiple sterols involved in cholesterol metabolic pathways in wild-type and cholesterol 24S-hydr

184 he result of differential gene expression in metabolic pathways, in conjunction with mitochondrial da

185 PCB 11 also altered several metabolic pathways, in particular vitamin B(6) metabolis

186 dome of proliferating hepatocytes to altered metabolic pathways including lipogenesis, fatty acid des

187 t Kac is widely distributed in gut microbial metabolic pathways, including anaerobic fermentation to

188 FXR plays critical roles in other lipid metabolic pathways, including fat oxidation; however, li

189 al of S. aureus mutants deficient in central metabolic pathways, including glycolysis, gluconeogenesi

190 It is involved in multiple DNA metabolic pathways, including Okazaki fragment maturatio

191 d dysregulated proteins involved in multiple metabolic pathways, including reduced Aldh3a1 and induce

192 ensate, cancer cells upregulated antioxidant metabolic pathways, including reductive carboxylation, p

193 mR in regulating the activity of a number of metabolic pathways, including two pathways, phenylacetat

194 hough immunological systems, brain function, metabolic pathways, inflammation and diet in the CLHLS c

195 l production, but difficulties incorporating metabolic pathways into complex sensor circuits have lim

196 onclusion this study identifies the HBP as a metabolic pathway involved in GEM resistance and provide

197 s, we performed in silico reconstructions of metabolic pathways involved in carbohydrate utilization

198 These features include metabolic pathways involved in lignocellulose breakdown,

199 portal-to-central differences in almost all metabolic pathways involving carbohydrates, fatty acids,

200 This epigenetic mitochondrial-metabolic pathway is a potential antifibrotic therapeuti

201 The modular nature of metabolic pathways is exploited to facilitate efficient

202 o GWI chemicals/stress adversely impacts key metabolic pathways leading to muscle atrophy and loss of

203 activates a nuclear factor kappa B-dependent metabolic pathway, leading to aerobic glycolysis and pol

204 e levels of several proteins and thus of the metabolic pathways linked to the early and late remodell

205 rmation processing and up-regulation of some metabolic pathways, lipid and energy in particular.

206 s-associated specific bacteria and microbial metabolic pathways (mainly microbial sugar transport) af

207 As participants of metabolic pathways, metabolite and protein markers may a

208 date genes encode enzymes that work in lipid metabolic pathways, most of which define clear expressio

209 Metabolic pathways must be adapted to support cell proce

210 E+ also perturbed many metabolic pathways, namely amino acid and inflammation-r

211 indicate that nitric oxide targets the same metabolic pathways necessary for glucose stimulated insu

212 te that AHR contributes to the regulation of metabolic pathways necessary for the proliferation of tr

213 me taxa clustering and neurocircuit-relevant metabolic pathway network analysis for GABA, butyrate, g

214 Metabolic pathways not only provide the precursor molecu

215 that identify thiols with potential roles in metabolic pathways, nutritional value of vegetables, or

216 number of genetic factors are related to the metabolic pathway of benzopyrene, a main compound in cig

217 rome P450 monooxygenases is one of the major metabolic pathways of arenes in eukaryotes.

218 The metabolic pathways of CD4(+) T cells and macrophages det

219 MYC have downstream effects on intracellular metabolic pathways of clonal plasma cells (PCs).

220 that intestinal inflammation reprograms the metabolic pathways of Enterobacteriaceae, such as Escher

221 This review discusses metabolic pathways of relevance to the origin of life in

222 , 46 kinetically profiled) selected from >35 metabolic pathways of strong biological significance.

223 niques to map the complex and interconnected metabolic pathways of the heart; however, normalization

224 he possible differences of the intracellular metabolic pathways of their clonal PCs.

225 Analyzing the expression pattern of metabolic pathways of two hematopoietic cell lines, we f

226 tated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly chan

227 ed biochemical mechanisms and assembled core metabolic pathways on an anoxic Earth.

228 and differentiation, but whether endogenous metabolic pathways or nutrient availability predispose s

229 ype, disturbances in other organ systems and metabolic pathways outside the brain have attracted atte

230 -characterized for its role as a coenzyme in metabolic pathways, particularly those involved in energ

231 d to the fungiculture environment, codifying metabolic pathways potentially relevant to the fungus-gr

232 To validate the importance of four metabolic pathways predicted by the model, we have perfo

233 io, along with the dysregulation scores of 3 metabolic pathways, primary bile acid biosynthesis, fatt

234 in IgAN and SAGN, with a lower abundance of metabolic pathway proteins and a higher abundance of ext

235 ures associated with clinical biomarkers and metabolic pathways provide clues to the roles bacteria p

236 p3-deficient T(reg) cells by targeting their metabolic pathways, providing opportunities to restore t

237 ight 1) the relationship between obesity and metabolic pathways putatively driving hepatic steatosis

238 es with activated lipolysis, glycolysis, and metabolic pathways regulated by AMPK.

239 The cyclooxygenase (COX) metabolic pathway regulates immune responses and inflamm

240 contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calc

241 Perturbation in metabolic pathways related to arginine and proline metab

242 Metabolic pathways related to the glycolytic by-product

243 S. aureus Together, these data elucidate the metabolic pathways required for staphylococcal infection

244 regulatory function) is dictated by distinct metabolic pathways requiring the availability of specifi

245 aired the transcriptional control of glucose metabolic pathway, resulting in markedly attenuated gluc

246 omeostasis, and any perturbation in distinct metabolic pathways results in the activation of this inf

247 Metabolites abundances and personalized metabolic pathways scores were used to derive machine le

248 dies the problem of prediction of classes of metabolic pathways (series of chemical reactions occurri

249 progression and the key proteins in the BCAA metabolic pathway serve as possible prognostic and diagn

250 own prosthetic group for enzymes involved in metabolic pathways such as oxygen transport and electron

251 We identified metabolic pathways such as phenylpropanoid metabolism, a

252 ative tissues and redirect nutrients towards metabolic pathways supporting reproductive success.

253 De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohyd

254 systems are interconnected through a central metabolic pathway that becomes deregulated under specifi

255 Here, we identified a myometabolite-mediated metabolic pathway that is essential for the beneficial m

256 Here, we decode a previously unknown E. coli metabolic pathway that produces a family of hybrid pteri

257 We map a metabolic pathway that rescues disease phenotypes in mtC

258 nducted a high-throughput screen to identify metabolic pathways that affect T3SS expression.

259 munometabolism, the changes in intracellular metabolic pathways that alter the function of these high

260 d by the simultaneous stimulation of ETR and metabolic pathways that consume the direct products of E

261 cells with implications for bioenergetic and metabolic pathways that control cellular homeostasis in

262 Our results highlight several metabolic pathways that exhibit functional similarity in

263 activity towards the utilization of specific metabolic pathways that may be beneficial for embryo via

264 high-capacity electron sink required by many metabolic pathways that must be flexibly coordinated and

265 However, metabolic pathways that regulate these oxygen and 2-OG s

266 This is an innovator view in elucidation of metabolic pathways that represent the biochemistry of th

267 ter (ISC) biogenesis are two major mammalian metabolic pathways that require iron.

268 ment by flexibly reprogramming intracellular metabolic pathways that subsequently alter immune functi

269 e-and its key role in the regulation of cell metabolic pathways that underly normal human T cell resp

270 M ciliates reveals functional adaptations of metabolic pathways that were present in their last commo

271 ssential micronutrient that functions in two metabolic pathways: the canonical propionate breakdown p

272 We review the contribution of each major metabolic pathway to autoimmune diseases, with a focus o

273 Together, PBS3 and EPS1 form a two-step metabolic pathway to produce SA from isochorismate in Ar

274 ion of genes outside the vitamin D canonical metabolic pathway to the genetic architecture of 25OHD.

275 astatic niche rely on the same nutrients and metabolic pathways to activate growth signaling as cance

276 Cancer cells often reprogram their metabolic pathways to adapt to environmental challenges

277 Cancer cells induce specific metabolic pathways to alleviate the increased oxidative

278 size, RNA, and protein content, and induces metabolic pathways to cope with the increased demand for

279 pportunities to reshape the TME by targeting metabolic pathways to favor immunity.

280 magnitude of the contribution of identified metabolic pathways to fitness in different community con

281 s a critical micronutrient that controls DNA metabolic pathways to maintain the host genomic stabilit

282 Perturbations in lipid metabolic pathways to meet the bioenergetic and biosynth

283 how soil Pseudomonas species reprogram their metabolic pathways to prioritize siderophore biosynthesi

284 cycle as a biochemical hub linking multiple metabolic pathways to stimulate ripening through an alte

285 metagenomic analysis functionally linked 26 metabolic pathways to the diurnal oscillation of gut bac

286 LBL favored energy metabolism and redirected metabolic pathways toward the synthesis of diverse prima

287 asmic lyases which dictate glycosaminoglycan metabolic pathways; understanding of endo sulfatase acti

288 We used this model to show how metabolic pathway usage allows the worm to adapt to diff

289 16 weeks and examined its effect on hepatic metabolic pathways using stable isotope resolved metabol

290 data suggest that significant differences in metabolic pathway utilization distinguish EMT and papill

291 lying our curated framework to signaling and metabolic pathways, we reduced the average assay develop

292 the selected time-points, and that different metabolic pathways were activated in their transcriptome

293 Major metabolic pathways were branched-chain amino acid metabo

294 Some metabolic pathways were specific to some MAGs, including

295 ol biosynthesis and iron uptake as essential metabolic pathways when lysosomal pH is altered.

296 oliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to g

297 cation end-products) play a critical role in metabolic pathways, which we envisage could maintain a c

298 feature-reduction methods disclosed a set of metabolic pathways whose presence and/or expression corr

299 e basics of intermediary metabolism and core metabolic pathways will be discussed, along with their r

300 The intersection of lipid metabolic pathways with apical domain growth provides a