ライフサイエンスコーパス: metabolic regulation

1 rotein modifications (PTMs) in mitochondrial metabolic regulation.

2 during neonatal life is pivotal for lifelong metabolic regulation.

3 ealth of data into an understanding of plant metabolic regulation.

4 ments seem to indicate WWOX's involvement in metabolic regulation.

5 significant role in protein utilization and metabolic regulation.

6 cers through a mutant-specific dependency in metabolic regulation.

7 s that is thought to have a critical role in metabolic regulation.

8 nd implicate TLR3 as a key control system in metabolic regulation.

9 os(t)ide-metabolizing enzymes susceptible to metabolic regulation.

10 , protein synthesis is tightly controlled by metabolic regulation.

11 plication to both efficiency improvement and metabolic regulation.

12 egulatory T cells did not require leptin for metabolic regulation.

13 erm activation, aqueous humor formation, and metabolic regulation.

14 are powerful approaches to explore cellular metabolic regulation.

15 NO-CoA-mediated S-nitrosylation may subserve metabolic regulation.

16 tion that involves p53/NF-kappaB coordinated metabolic regulation.

17 t FXR-associated proteins that contribute to metabolic regulation.

18 mportant roles in the periphery including in metabolic regulation.

19 branes is associated with cell signaling and metabolic regulation.

20 ic flux" was proposed as a novel impetus for metabolic regulation.

21 nvolved in whole-body energy homeostasis and metabolic regulation.

22 its glycolytic flux and uses this signal for metabolic regulation.

23 d cellular RAS play diverse roles, including metabolic regulation.

24 ese data now provide powerful tools to study metabolic regulation.

25 ed "metabolic memory," which implies altered metabolic regulation.

26 suggested a link between p21 expression and metabolic regulation.

27 tabolic control analysis allows the study of metabolic regulation.

28 liferative effects also manifest in specific metabolic regulation.

29 l of growth, whereas Akt2 has been linked to metabolic regulation.

30 modification are major means of fast-acting metabolic regulation.

31 a key center involved in nutrient-dependent metabolic regulation.

32 way in influencing hypothalamic circuits and metabolic regulation.

33 d particularly the hypothalamus for exerting metabolic regulation.

34 oteins needed for its folding, assembly, and metabolic regulation.

35 recognition of host environment to bacterial metabolic regulation.

36 metabolic pathway can interact to fine-tune metabolic regulation.

37 ndamental role in controlling excitable cell metabolic regulation.

38 lar processes such as lifespan extension and metabolic regulation.

39 processes such as gene silencing, aging, and metabolic regulation.

40 ng, suggesting that at least some contribute metabolic regulation.

41 keletal systems, and to body composition and metabolic regulation.

42 localization in the flagellum and/or altered metabolic regulation.

43 target for central appetitive and peripheral metabolic regulation.

44 and developmental delays, implicating IMD in metabolic regulation.

45 , and providing an additional mode of global metabolic regulation.

46 tifies a new level of phospholipase-mediated metabolic regulation.

47 l depends on a non-conventional mechanism of metabolic regulation.

48 ole for this family of regulators in central metabolic regulation.

49 iour, circadian rhythmicity, development and metabolic regulation.

50 se and these may be relevant for longer-term metabolic regulation.

51 is under investigation as a possible site of metabolic regulation.

52 ropriate, tissue-specific, developmental and metabolic regulation.

53 transcriptional control is involved in this metabolic regulation.

54 ol of available beta subunits is under tight metabolic regulation.

55 that is structurally specific and subject to metabolic regulation.

56 operate with TGF-beta effectors in mediating metabolic regulation.

57 enes involved in cell death, cell cycle, and metabolic regulation.

58 ctions including virulence, conjugation, and metabolic regulation.

59 aboratory focuses on cellular metabolism and metabolic regulation.

60 he transcriptome that form the basis of this metabolic regulation.

61 e hormone oxytocin (OT) may be important for metabolic regulation.

62 y roles in immunity, tissue homeostasis, and metabolic regulation.

63 linking protein phosphorylation cascades to metabolic regulation.

64 t is facilitated through transcriptional and metabolic regulation.

65 previously unrecognized role for snoRNAs in metabolic regulation.

66 re we show that even in the heterogeneity of metabolic regulation a distinct signature encompassed mo

67 kinase implicated in energy homeostasis and metabolic regulation across eukaryotic species.

68 5)-trisphosphate) is potentially involved in metabolic regulation, activation of hypertrophy, and sur

69 ever, the mechanisms by which NOX4-dependent metabolic regulation affect the innate immune response r

70 including mitosis, signal transduction, and metabolic regulation, also differ between stem cells and

71 titute a useful probe into the mechanisms of metabolic regulation and an important target to develop

72 at unconventional activities of p53, such as metabolic regulation and antioxidant function, are criti

73 ly plays a significant role in mitochondrial metabolic regulation and apoptosis in response to cytoso

74 ence supporting VDAC's role in mitochondrial metabolic regulation and apoptosis, where VDAC oligomeri

75 As expected, genes associated with metabolic regulation and carbohydrate metabolism were di

76 ncover an important role for the mtCU beyond metabolic regulation and cell death and demonstrate that

77 calcium (mCa(2+)) has a central role in both metabolic regulation and cell death signalling, however

78 sues is needed for a better understanding of metabolic regulation and development of new treatments f

79 resent evidence for oncogene-directed cancer metabolic regulation and discuss the importance of ident

80 e in K(ATP) channel trafficking and membrane metabolic regulation and dysfunction in these pathways r

81 ant role in breast cancer progression and in metabolic regulation and energy homeostasis.

82 selenoprotein, and our understanding in the metabolic regulation and function of this abundant selen

83 r results suggest an intriguing link between metabolic regulation and hepatocarcinogenesis.

84 sociated with molecular processes related to metabolic regulation and inflammation.

85 rotein kinase (AMPK) family is important for metabolic regulation and is highly conserved from yeast

86 alian liver development and also crucial for metabolic regulation and liver function.

87 nd primary ciliary signalling, have roles in metabolic regulation and may exert their effects through

88 pite the importance of mitochondrial Ca2+ to metabolic regulation and mitochondrial function, and to

89 ) isoform-specific action; and cross-talk in metabolic regulation and neural development.

90 t into the crosstalk between kinase-mediated metabolic regulation and platinum-based chemotherapy res

91 gh specific protein targets, which engage in metabolic regulation and stress responses to support cel

92 s work examines the interplay between these, metabolic regulation and the creatine kinase equilibrium

93 with its implications for issues related to metabolic regulation and the evolution of cellular metab

94 Here we show, surprisingly, that metabolic regulation and the heat-shock/stress response

95 ine a link between a key pathway controlling metabolic regulation and the regulation of the mammalian

96 etabolism suggest an intriguing link between metabolic regulation and TRPV channel activity.

97 However, ATM also has been implicated in metabolic regulation, and ATM deficiency is associated w

98 t adulthood, including cell differentiation, metabolic regulation, and inflammation.

99 Leptin is an adipokine involved in metabolic regulation, and obese individuals have higher

100 protection from apoptosis, drug resistance, metabolic regulation, and protein quality control/ubiqui

101 ly unknown interplay between SOD1 acylation, metabolic regulation, and SOD1-mediated cell survival.

102 g nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required f

103 proteins (IGFBPs) play a significant role in metabolic regulation, and there is growing evidence that

104 and have key roles in mechano-transduction, metabolic regulation, and vascular permeability.

105 oxia involve systemic physiological changes, metabolic regulation, and vascular remodeling.

106 s highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulat

107 ular functions, including energy production, metabolic regulation, apoptosis, calcium homeostasis, ce

108 ase in mycobacterial cell wall synthesis and metabolic regulation are discussed.

109 As a result, immune response and metabolic regulation are highly integrated and the prope

110 Very few examples of metabolic regulation are known in the gastric pathogen H

111 ontributions of direct and central inputs to metabolic regulation are likely of comparable magnitude,

112 yclin-dependent kinase/cyclin regulation and metabolic regulation as a means to limit proliferation,

113 These results identify metabolic regulation as a potential therapeutic target f

114 nd the up-regulation is involved in adaptive metabolic regulation as age increases, whereas impairmen

115 dings highlight coordinated invasion and its metabolic regulation as potential therapeutic targets of

116 ular and immune systems, skeletal muscle and metabolic regulation as well as ageing and cancer.

117 the roles of prostaglandin E(2) signaling in metabolic regulation beyond the reported stimulation of

118 al sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechani

119 f how ratio-sensing is achieved in yeast GAL metabolic regulation, but also elucidated design princip

120 te that the JNK2 isoform is also involved in metabolic regulation, but its function is not obvious wh

121 In mammals, the enzyme is subject to metabolic regulation, but regulatory mechanisms of bacte

122 is known about the mechanisms underlying the metabolic regulation by CDK4.

123 identifying additional conserved features of metabolic regulation by condensates/filaments.

124 ulator of IGF bioavailability because of its metabolic regulation by glucoregulatory hormones.

125 s, prompting this investigation of potential metabolic regulation by Icmt.

126 bolism, but also affects non-cell-autonomous metabolic regulation by induced expression of a potent m

127 l sympathetic innervation and integration of metabolic regulation by multiple hormones.

128 ea may be due to, at least in some part, the metabolic regulation by Sirtuin family proteins whose fu

129 ognition, and executive control can override metabolic regulation by talking to the hypothalamus.

130 Overexpression of Akt overcomes metabolic regulation by UCP3, rescuing carcinogenesis.

131 a fulfill essential roles in ATP production, metabolic regulation, calcium signaling, generation of r

132 es, we analysed the steady state response of metabolic regulation (catabolic or anabolic) with respec

133 metabolism in the context of cell-autonomous metabolic regulation, cell-cell interactions, and system

134 Also related to cellular metabolic regulation, cellular autophagy has also been f

135 Much of our knowledge about cardiac metabolic regulation comes from studies focused on mitoc

136 Whether this metabolic regulation contributes to premature Parkinsoni

137 mor suppressors implicated in cell signaling/metabolic regulation converge within the AKT signal tran

138 enance mechanisms, DNA damage signalling and metabolic regulation cooperate to drive the ageing proce

139 ors confirm the importance of this target in metabolic regulation, describe novel models for assessin

140 reaction models, the models based on current metabolic regulation did not readily describe the phenot

141 Deviant metabolic regulation due to increased flux through aldos

142 derstanding of biological events relevant to metabolic regulation during climacteric and nonclimacter

143 rsue the identities of the genes involved in metabolic regulation during desiccation.

144 st that mitochondrial transcription is under metabolic regulation during early Xenopus embryogenesis.

145 y highlights the still unappreciated role of metabolic regulation during organogenesis, and suggests

146 This style of metabolic regulation enables pathogen sensing of specifi

147 n several physiological functions, including metabolic regulation, energy storage, and endocrine func

148 tively suggest multiple adaptive pathways of metabolic regulation following blocked chylomicron assem

149 Our report suggests a mechanism of metabolic regulation for chlorosome biogenesis.

150 eceptor GPR50 plays an important function in metabolic regulation for entry into torpor.

151 To test the importance of metabolic regulation for host responses to bacterial inf

152 ighting the significance of upstream primary metabolic regulation for the diversification of speciali

153 As well, lactate binding may affect metabolic regulation, for instance binding to G-protein

154 in which kisspeptin neurons are subjected to metabolic regulation, from early developmental stages to

155 se presence and abundance are key to much of metabolic regulation, from subcellular compartments to w

156 s that several robust properties emerge from metabolic regulation, from the molecular level (e.g. hom

157 nisms of aging that invoke the importance of metabolic regulation, genetic stability and stress resis

158 aracterize the transcript level component of metabolic regulation, genome-wide changes in transcript

159 In recent years, the emerging role of p53 in metabolic regulation has been a topic of great interest.

160 of function of RELMbeta on colon cancer and metabolic regulation has not been fully elucidated.

161 The mechanisms underlying flavonoid-induced metabolic regulation have not been completely establishe

162 into amino acid, fatty-acid and carbohydrate metabolic regulation (i.e. incorporation, flux, and oxid

163 nceptual and computational basis for mapping metabolic regulation in additional cancers.

164 ammals, and it underscores the importance of metabolic regulation in aging, suggesting a general appl

165 ctivator protein or CAP) plays a key role in metabolic regulation in bacteria and has become a widely

166 systematically chart the different layers of metabolic regulation in breast cancer cells, predicting

167 on has differential effects on AMPK-mediated metabolic regulation in cancer and healthy cells and exp

168 temporal ATP buffering and dynamic roles in metabolic regulation in cells displaying high and variab

169 system and the gut with strong relevance for metabolic regulation in context of inflammation.

170 e studies, with a number of implications for metabolic regulation in health and disease.

171 d YY1 functions broaden our understanding of metabolic regulation in intestinal stem cell homeostasis

172 its availability by G3PP adds a key level of metabolic regulation in mammalian cells, and G3PP offers

173 key role in insulin signaling, thus enabling metabolic regulation in mammalian cells.

174 ease of blubber sampling and its key role in metabolic regulation in marine mammals.

175 molecular mechanisms underlying the primary metabolic regulation in mung bean during post-germinatio

176 hypothesized that a combination of impaired metabolic regulation in obese animals prior to OVX plus

177 To examine metabolic regulation in postischemic hearts, we examined

178 rotein kinase (AMPK) family is important for metabolic regulation in response to stress.

179 Little is known about metabolic regulation in stem cells and how this modulate

180 Metabolic regulation in Streptomyces species is of inter

181 g of C(4)-specific features in evolution and metabolic regulation in the context of C(4) photosynthes

182 g a connection between genome plasticity and metabolic regulation in the early stages of stress respo

183 dies have highlighted the importance of such metabolic regulation in the endothelium and uncovered co

184 ess the role of the second adipocyte FABP in metabolic regulation in the presence and deficiency of o

185 enhancer to address the role of this FABP in metabolic regulation in the presence or absence of obesi

186 However, biological interpretations of metabolic regulation in these datasets are hindered by i

187 se model underscored the significance of p53 metabolic regulation in tumor suppression, while also al

188 m to study signaling, neurodegeneration, and metabolic regulation in vivo, we asked whether DJ-1 cont

189 e for insulin- and nutrient-mediated hepatic metabolic regulation in vivo.

190 xamined the Ci-dependent transcriptional and metabolic regulation in wild-type Synechocystis sp. PCC

191 ise new questions about oxygen transport and metabolic regulation in working muscles.

192 nduced p21 expression in tissues involved in metabolic regulation including liver, pancreas and hypot

193 s possible that Trx functioned originally in metabolic regulation independently of O2, thus raising t

194 stent environmental contaminants that affect metabolic regulation, inflammation, and other factors im

195 Metabolic regulation influences cell proliferation.

196 nt advances in our understanding of how this metabolic regulation influences circadian timing.

197 A major aspect of metabolic regulation involves the appropriate storage an

198 Homeostatic metabolic regulation is achieved through metabolite sens

199 es that occur during long-term infection, as metabolic regulation is complex and takes place on diffe

200 in L. monocytogenes and determined that its metabolic regulation is implicated in cytosolic survival

201 Whether alternative splicing contributes to metabolic regulation is largely unknown.

202 Metabolic regulation is mediated by changes in ATP and M

203 adipose tissue homeostasis and its impact on metabolic regulation is not understood.

204 icular, we hypothesized that derangements in metabolic regulation may accelerate retinal dysfunction

205 ion of recombination, chromosomal stability, metabolic regulation, meiosis, and aging.

206 tro and in vivo and discuss how differential metabolic regulation might facilitate T-cell function vi

207 sults highlight a unique autophagy-dependent metabolic regulation of adaptive and innate T cells, whi

208 ivity in C57BL/6 mice and is involved in the metabolic regulation of adipose tissue.

209 ional regulation of tight junction proteins, metabolic regulation of barrier components, and changes

210 re interested to determine if examination of metabolic regulation of BCL-2 proteins may provide insig

211 NO has been implicated in the local metabolic regulation of blood flow in contracting skelet

212 rtant post-translational modification in the metabolic regulation of both prokaryotes and eukaryotes.

213 characterize both the primary metabolism and metabolic regulation of C. acetobutylicum.

214 iology and clarify mechanisms underlying the metabolic regulation of CaMKII and apoptosis.

215 Investigation of the metabolic regulation of cancer stem cells is an emerging

216 However, the metabolic regulation of CD4 Tmem differentiation is not

217 ons in the ventromedial hypothalamus prevent metabolic regulation of circadian responses to light dur

218 d rectifier K(+) channels may be involved in metabolic regulation of coronary and cerebral blood flow

219 s provides a versatile method to monitor the metabolic regulation of electrophilic cofactors and disc

220 This review summarizes the metabolic regulation of endothelial glycocalyx HA and it

221 is the nonerythroid action of EPO, including metabolic regulation of fat accumulation and glucose hom

222 The evidence for metabolic regulation of flavonoid genes during seedling

223 rative effects during liver regeneration and metabolic regulation of FXR was elusive.

224 The metabolic regulation of glucose release and gluconeogene

225 ential for both tissue-specific and hormonal/metabolic regulation of GLUT4 expression.

226 Our results suggest that the metabolic regulation of GS expression in plants is contr

227 e A (acetyl-CoA), we investigated a role for metabolic regulation of histone acetylation during the D

228 efore, our study reveals a novel paradigm of metabolic regulation of histone modifications.

229 We delineated the mechanism of metabolic regulation of HNF-1alpha/FXR signaling.

230 Understanding metabolic regulation of HSC function has significant imp

231 establishes a crucial role of PTPMT1 in the metabolic regulation of HSC function.

232 f Cited2 and the underlying mechanism in the metabolic regulation of HSCs will provide a better under

233 cent studies have helped define and redefine metabolic regulation of HSCs.

234 m cells (HSCs) and its potential role in the metabolic regulation of HSCs.

235 ing that these neurons are downstream of the metabolic regulation of hunger.

236 s may be relevant to both hypoxic damage and metabolic regulation of IP3 signaling processes.

237 Metabolic regulation of K-ATP channels is mediated by ch

238 Although metabolic regulation of KATP channel activity is believe

239 ar second messengers mediate transmitter and metabolic regulation of Kir channels.

240 array of known mechanisms that underlie the metabolic regulation of KISS1 expression and kisspeptin

241 Feedback metabolic regulation of MTHFS by 10-formylTHF indicates

242 The metabolic regulation of neuronal genes by CtBP will open

243 s suggest that SnRK2.6 mediates hormonal and metabolic regulation of plant growth and development and

244 glucose dependence may occur in part through metabolic regulation of pro-apoptotic Bcl-2 family prote

245 ovides novel opportunities for signaling and metabolic regulation of protein deacetylation.

246 pH biosensing by TGN PI4P allows for direct metabolic regulation of protein trafficking and cell gro

247 Metabolic regulation of Puma was mediated through combin

248 Secondly, we examined the metabolic regulation of pyruvate dehydrogenase (PDH) and

249 the possible mechanisms contributing to the metabolic regulation of retinal blood flow under physiol

250 ent in male and female rats, suggesting that metabolic regulation of rWAT and iWAT is sexually dimorp

251 rient-responsive and plays multiple roles in metabolic regulation of signaling and gene expression.

252 rtance of mitochondrial bioenergetics in the metabolic regulation of sirtuins and cytosolic signaling

253 ate an essential role for Lk neuropeptide in metabolic regulation of sleep.

254 Here, we examined the role and metabolic regulation of the antiapoptotic Bcl-2 family p

255 , we examined the involvement of RAS2 in the metabolic regulation of the clock in the circadian model

256 sufficient for tissue-specific and hormonal/metabolic regulation of the fatty-acid synthase (FAS) ge

257 the developmental, cell-specific, light and metabolic regulation of the homologous C4 PPCZm1 promote

258 article, we review current knowledge of the metabolic regulation of the KATP channel and provide evi

259 deux orchestrates the pivotal role of ATP in metabolic regulation of the KATP channel.

260 DMADP constitutes an important mechanism of metabolic regulation of the MEP pathway and indicates th

261 Understanding the metabolic regulation of the MEP pathway is important con

262 ctivity potentially provides a mechanism for metabolic regulation of the reactions catalyzed by these

263 Metabolic regulation of vascular tone is an important de

264 toll-like receptors, and key changes in the metabolic regulation of visceral white adipose tissue.

265 D metabolites is critical to studies of the metabolic regulation of vitamin D and its impact on heal

266 involve myogenic, neural control as well as metabolic regulations of cerebral vasculature in respons

267 es yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome.

268 was higher in M5, suggesting a difference in metabolic regulation or a butyrate stress response in M5

269 Autophagy, for either metabolic regulation or defence, involves the formation

270 , many highly conserved proteins involved in metabolic regulation or the cell stress response have a

271 rocess affecting brain regions necessary for metabolic regulation or whether they drive the degenerat

272 ns of common biological pathways that affect metabolic regulation, organ function, antioxidant defens

273 immune receptor and that beyond sphingolipid metabolic regulation ORM proteins can also act as select

274 sic connections between p53-mediated DDR and metabolic regulation remain incompletely understood.

275 lic behaviors, but the system-wide impact of metabolic regulation remains largely uncharacterized.

276 p53 is directly involved in mature adipocyte metabolic regulation remains unclear.

277 signal transducing systems are necessary for metabolic regulation, resistance to antibiotics and anti

278 recently described functions in genetic and metabolic regulation, signal transduction, and DNA repai

279 ochromatic gene silencing as a mechanism for metabolic regulation, since repeated sequences nucleate

280 method has great potential in RNA decay and metabolic regulation studies via individual mRNA labelin

281 acellular glutamine levels are under tighter metabolic regulation than previously thought.

282 Thus, 32 provides insight into the amount of metabolic regulation that can be restored following achi

283 protein expression modifications and altered metabolic regulation that define glioblastoma.

284 tions suggest novel roles of FAT10 in immune metabolic regulation that impact aging and chronic disea

285 To investigate this metabolic regulation, the Leishmania GMPR was cloned and

286 the interplay between enzyme specificity and metabolic regulation, the metabolic interdependence of m

287 vides an adequate supply, in contrast to the metabolic regulation theory which requires permanent hyp

288 te-secreted proteins play important roles in metabolic regulation through autocrine, paracrine, and e

289 a metabolic checkpoint in Tregs that couples metabolic regulation to immune homeostasis and tolerance

290 sting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biolog

291 Leptin-mediated metabolic regulation was critical, as transgenic express

292 CV core protein is one of the key players in metabolic regulation, we also examined its contribution

293 tent with the emerging views of caspase-1 in metabolic regulation, we find that caspase-1-deficient m

294 all changes in genes related to intermediary metabolic regulation were replicated in cultured fetal h

295 ort suggested that the thioredoxin-dependent metabolic regulation, which is widespread in all domains

296 factor signaling may coordinately integrate metabolic regulation with established signaling function

297 n linked to cancer signaling pathways and to metabolic regulation with involvement in autophagy, cell

298 ne is subject to complex tissue-specific and metabolic regulation, with a profound impact on insulin-

299 ssion of lactate formation by DCA may impair metabolic regulation within the diaphragm during resisti

300 S polymerization disrupts E. coli growth and metabolic regulation without reducing CTP levels.