ライフサイエンスコーパス: metabolism

1 ar parasite Toxoplasma gondii reprograms its metabolism.

2 tochondrial membrane that regulates cellular metabolism.

3 ed via small elevations in arterial PCO2 and metabolism.

4 molecular basis of tumor development and GSL metabolism.

5 M3, and CB, signifying differences in lipid metabolism.

6 me biogenesis and function, as well as lipid metabolism.

7 impairs phagocytosis, and increases TB drug metabolism.

8 tivation by disruption of Keap1 impacts bone metabolism.

9 erophospholipid, bile acid and acylcarnitine metabolism.

10 ith P-gp, a major pathway for clarithromycin metabolism.

11 inated changes in mitochondrial function and metabolism.

12 n muscle force and skeletal muscle oxidative metabolism.

13 regulator of cellular and whole-body energy metabolism.

14 ar receptors that regulate genes involved in metabolism.

15 a consortium by heterogenous polysaccharide metabolism.

16 at also has a role in cancer cell growth and metabolism.

17 h is enabled by the reprogramming of glucose metabolism.

18 sts the importance of this enzyme for xylose metabolism.

19 plasmic reticulum (ER), and lysosomes in HSC metabolism.

20 obesity-associated deterioration of glucose metabolism.

21 mediator of the functions of c-Myc in cancer metabolism.

22 ough chromatin regulation to rewire cellular metabolism.

23 suggesting a putative role in mitochondrial metabolism.

24 es to the control of cell survival and lipid metabolism.

25 ajor role in the physiological regulation of metabolism.

26 sophila adults regulate feeding behavior and metabolism.

27 ular imbalance of the inositol polyphosphate metabolism.

28 postures and associated reductions in muscle metabolism.

29 tic lipokines that connect glucose and lipid metabolism.

30 protein turnover, and splanchnic amino acid metabolism.

31 data suggest that RPA may play a role in RNA metabolism.

32 nces due to temporarily altered brain energy metabolism.

33 nes involved in proliferation and glycolytic metabolism.

34 nancy-related physiologic changes in glucose metabolism.

35 enes involved in transmembrane transport and metabolism.

36 eir role in organisms' primary and secondary metabolism.

37 reveal additional roles for ATMs in systemic metabolism.

38 omedical NMR and MRI of cellular and in vivo metabolism.

39 d to form 4-coumaric acid in phenylpropanoid metabolism.

40 ly implicated in regulation of adult cardiac metabolism.

41 nscription and the reprogramming of cellular metabolism.

42 ORC1), a master regulator of cell growth and metabolism.

43 the various pathways involved in glyoxylate metabolism.

44 itochondrial Ca(2+) entry and regulates cell metabolism.

45 ons linked to transmethylation and polyamine metabolism.

46 number of genes involved in N signalling and metabolism.

47 for both mitochondrial and general parasite metabolism.

48 ith a variety of groups derived from primary metabolism.

49 (PPAR) delta as key regulator of osteoblast metabolism.

50 ation, as well as improved lipid and glucose metabolism.

51 d cycle, and monosaccharide and disaccharide metabolism.

52 as key components in determining cancer cell metabolism.

53 ablished roles in regulating food intake and metabolism.

54 are characterized predominately by anaerobic metabolisms.

55 ffspring, likely presenting strains on their metabolisms.

56 buting to different aspects of messenger RNA metabolism(5,6), is detectable on the majority of RNA:DN

57 nt DRAM (Distilled and Refined Annotation of Metabolism), a framework to translate the deluge of micr

58 ramides', 'creatine metabolism', 'fatty acid metabolism (acyl carnitine, polyunsaturated)' and 'hexos

59 small intestine, the major site for nutrient metabolism and absorption.

60 se Peli1 as an important regulator of T cell metabolism and antitumor immunity.

61 tionship between local increases in cerebral metabolism and appropriately matched increases in region

62 all redox cofactors with key roles in energy metabolism and are substrates for several NAD-consuming

63 port chain that functions in cellular energy metabolism and as a membrane antioxidant.

64 ed many of the same signals used to regulate metabolism and ATP production, such as calcium and react

65 AMPK is a central regulator of metabolism and autophagy.

66 e expression levels of proteins dedicated to metabolism and biosynthesis(1,2).

67 Glucose metabolism and calcium influx are involved in primiR-199

68 xpressed gene clusters in pathways involving metabolism and circadian rhythm were noted in insulin-re

69 MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic stat

70 onin signaling in CTR-POMC neurons on energy metabolism and demonstrate the need for sex-specific app

71 nding miRNA signaling underlying cancer cell metabolism and development of new strategies for the tre

72 adapt per hour) by simultaneously measuring metabolism and division of thousands of individual Sacch

73 tant hormones that regulate host cholesterol metabolism and energy balance via several nuclear recept

74 te a major role for RNase AM in cellular RNA metabolism and establish a biological role for the first

75 megabiota has a negative impact on ecosystem metabolism and functioning; and (iii) their reduction ha

76 Mitochondrial metabolism and gene expression are highly regulated to a

77 lecular mechanism of regulation of secondary metabolism and gene expression in the glandular trichome

78 humans to examine pathways controlling lipid metabolism and gluconeogenesis.METHODSCross-sectional st

79 hydrates with their phosphorylation prior to metabolism and has been linked to GAS pathogenesis.

80 rough a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 (GLS1

81 lish a critical crosstalk between hepatocyte metabolism and HSC senescence that promotes tumour growt

82 Effectors alter host metabolism and immunity for the benefit of pathogens.

83 nscription factors with diverse functions in metabolism and immunity-critically contribute to thymic

84 ntain proteins involved in DNA and chromatin metabolism and in transcription, respectively.

85 s a strong link between UVA-induced estrogen metabolism and increased susceptibility of females for F

86 re, we review topical findings in organismal metabolism and infection and highlight four emerging lin

87 udy was to characterize changes in glutamine metabolism and inflammation in human glioma samples and

88 partner (Shp) plays a complex role in lipid metabolism and inflammation.

89 AP couples TLR signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transducti

90 muscle may contribute to reduced amino acid metabolism and insulin resistance in MHD patients.

91 nd detect genetic changes involved in carbon metabolism and inter-specific interaction.

92 remains in excellent synchrony with cellular metabolism and its energy reserves.

93 Although the central role of NAD in plant metabolism and its regulatory role have been investigate

94 pair glucagon's action on hepatic amino acid metabolism and lead to hyperaminoacidemia and hypergluca

95 ctionally distinct from conventional glucose metabolism and leads to distinct metabolic requirements

96 The relationship between lipid metabolism and longevity remains unclear.

97 ability was associated with impaired glucose metabolism and lower glycolytic enzyme expression, rende

98 sary to better characterize both the primary metabolism and metabolic regulation of C. acetobutylicum

99 a Opn3-GPCR signaling that can regulate fuel metabolism and mitochondrial respiration.

100 c kinetic changes revealed the alteration of metabolism and neurotransmission in different brain regi

101 undwork for non-invasive probes of bacterial metabolism and offers prospects for detection of microbe

102 Our understanding of the metabolism and perception of cytokinin has made great st

103 tion of an immune response, a switch in cell metabolism and processes related to muscle contraction a

104 r receptors involved in beta-amyloid (Abeta) metabolism and progression of Alzheimer's disease (AD).

105 and to elucidate the role of SXR in PCB-153 metabolism and promotion of its harmful effects.

106 ere is marked interindividual variability in metabolism and resulting toxicity and effectiveness of d

107 ermore, genes involved in central and energy metabolism and ribosome biogenesis were dysregulated mor

108 nd protein analyses to evaluate sphingolipid metabolism and signaling post-MI.

109 y a crucial role in the regulation of energy metabolism and systemic glucose homeostasis.

110 ther regulatory mechanisms can influence RNA metabolism and the capacity of neurons to adapt.

111 Exercise modulates metabolism and the gut microbiome.

112 coupling between SLC7A11-associated cystine metabolism and the pentose phosphate pathway, and uncove

113 cted to intracellular pathways of fatty acid metabolism and therefore uniquely poised to communicate

114 significantly impact pathways mediating the metabolism and transport of glucose and pyruvate.

115 ple biological processes including trehalose metabolism and various families of transcription factors

116 and signaling), organ (eg, contractility and metabolism), and whole-body (eg, physical activity and a

117 hepatocytes as a critical regulator of lipid metabolism, and clinical trials targeting PCSK9 reduce c

118 absorption, poor solubility, high first-pass metabolism, and efficient efflux by P-glycoprotein.

119 o pharmacology and absorption, distribution, metabolism, and excretion testing.

120 uction in terrestrial heterotrophic biomass, metabolism, and fertility respectively.

121 he gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous

122 P solution on the structure, cell viability, metabolism, and function were determined.

123 nation altered methionine, lipid, and purine metabolism, and inhibited quiescence, which explains the

124 Inborn errors of metabolism are genetic conditions that can disrupt inter

125 ge number of molecules associated with lipid metabolism are known to be implicated in MNDs, there rem

126 Current methods for imaging cellular metabolism are limited by low sensitivities, costs or th

127 Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome.

128 e sequences reveals photosynthesis and lipid metabolism are preferentially retained after a recent WG

129 onse remain unclear and the effects on lipid metabolism are relatively unexplored.

130 ne which genes involved in apicoplast carbon metabolism are required for blood-stage parasite surviva

131 rdinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related d

132 tivation, but recent findings highlight cell metabolism as a crucial regulator of these processes.

133 tibility, implicating short-chain fatty acid metabolism as a key element conserved across multiple ho

134 Collectively, our data define cholesterol metabolism as an integral metabolic pathway for the opti

135 actor of the gamma-aminobutyric acid (GABA) metabolism as it catalyses the decarboxylation of glutam

136 we identify enzymes involved in carbohydrate metabolism as transcriptional targets of CRZ1/GnRHL1 sig

137 ological advances in genetic engineering and metabolism as well as by the realization that this metab

138 portunity for quantitating the robustness of metabolism, as cells respond to changes by inherently co

139 mediated transcriptional events, control the metabolism at several levels.

140 t DX314, but not all-trans-RA or previous RA metabolism blocking agents, appears to protect epidermal

141 systems as films not only avoids first-pass metabolism, but also provides pain-free administration,

142 pses can switch from glycolytic to oxidative metabolism, but to do so, they rely on activity-driven p

143 nological functions that regulate organismal metabolism by controlling insulin action, lipolysis, and

144 context-dependent regulation of endothelial metabolism by GW0742, where metabolic activity is reduce

145 late methanol differs from the typical sugar metabolism by only three enzymes, turning a non-methylot

146 enesis, SOX9 acts as a regulator of cellular metabolism by suppressing oxidation of fatty acids, and

147 Many cancers alter their proline metabolism by up-regulating the proline cycle and prolin

148 Crassulacean acid metabolism (CAM) evolved in arid environments as a water

149 of stomata in plants with crassulacean acid metabolism (CAM) is mainly shifted to the night period w

150 ight be related with the Crassulaceaean Acid Metabolism (CAM) of K.

151 progress in understanding crassulacean acid metabolism (CAM) systems and the integration of internal

152 eta-glucoside PTS transports salicin and its metabolism can differentially influence GAS pathophysiol

153 In conclusion, a defect in folate metabolism can lead to prenatal aqueduct stenosis and re

154 ology that provides direct insight into cell metabolism, cell dynamics and protein activity.

155 'Benzoate metabolism', 'ceramides', 'creatine metabolism', 'fatty

156 s encoding other enzymes involved in glucose metabolism compared to follower cells.

157 f the liver, as an intermediate organ for VD metabolism, contributes partly to this deficiency.

158 H, prevalent in people with impaired glucose metabolism, contributes to cardiovascular disease.

159 her show that RsaD redirects carbon overflow metabolism, contributing to stationary phase cell death

160 including heterotrophy, sulfur and hydrogen metabolism, denitrification, and fermentation.

161 this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on

162 For metabolism, diet and nutrition are the major environment

163 dence suggests that individuals with glucose metabolism disorders are susceptible to mortality associ

164 that the deletion of ALX dysregulated energy metabolism driving toward age-related obesity.

165 downstream, the hierarchical organization of metabolism due to the flux ordering has direct applicati

166 of potential therapies to target macrophage metabolism during heart failure, including antidiabetic

167 igratory cells selectively utilize oxidative metabolism during the process of migration to metabolize

168 Many different enzymes in intermediate metabolism dynamically assemble filamentous polymers in

169 The absorption, distribution, metabolism, elimination, and toxicity (ADMET) properties

170 ferentiation (FLG and FLG2), lipid synthesis/metabolism (ELOVL3 and FA2H), and tight junction (CLDN8)

171 ioning, as the link among electron transfer, metabolism, energy conservation, and filament growth in

172 d with improved glucose tolerance, increased metabolism, energy expenditure, and locomotor activity,

173 ween VTE and natural variation in chorismate metabolism explained by transcriptional reprogramming of

174 ding major changes in transcripts related to metabolism, expression of LEA and ELIP genes, and eviden

175 signatures indicative of enhanced fatty acid metabolism (FAM).

176 Benzoate metabolism', 'ceramides', 'creatine metabolism', 'fatty acid metabolism (acyl carnitine, pol

177 ecurring folds were central to the origin of metabolism: ferredoxin and Rossmann-like folds.

178 ecies exhibits expansion of its carbohydrate metabolism gene repertoire including the acquisition of

179 etal transport (feoA, mntH, sirA), anaerobic metabolism genes (adhE, pflA, nrdDG) and a large number

180 diurnal cycles are well known to control the metabolism, growth, and cell division.

181 d its downstream targets in angiogenesis and metabolism has been unsuccessful so far in the breast ca

182 Metabolism has emerged as a potent means to control matu

183 ities of one carbon, glutathione and sulfide metabolisms have recently emerged as novel pathomechanis

184 Among genes involved in glucose metabolism, hexokinase domain containing 1 (HKDC1) was i

185 se as a diagnostic tool for inborn errors of metabolisms (IEMs) in the near future.

186 Recent work suggests that cholesterol metabolism impacts innate immune responses against infec

187 d that 5-PAHSA primes adipocytes for glucose metabolism in a different way from insulin, promoting DN

188 apeutic strategy may alter myocardial energy metabolism in a manner that reverses the deleterious met

189 ease mechanisms, genetic variation, and drug metabolism in a more physiologically relevant setting.

190 We explore cobalt metabolism in a Prochlorococcus isolate from the equator

191 nserved effect of upregulating mitochondrial metabolism in both fly and mammalian adipose tissue, whi

192 te receptor-1 (S1PR1) expression and glucose metabolism in CD4(+) T cells as potential mechanisms for

193 ere to detect differences in brain (18)F-FDG metabolism in CDCS patients with different clinical pres

194 Amino acid metabolism in different cells and their cross-talk shape

195 in the circulation, where it alters nutrient metabolism in intestinal epithelial cells and microbiome

196 than disturbed haemodynamic factors or lipid metabolism in MCI pathogenesis.

197 tative and temporal control of gut bacterial metabolism in order to reveal its local and systemic eff

198 that addressed the topic of targeting lipid metabolism in PCa.

199 MCU influences phototransduction and energy metabolism in photoreceptors using a mcu(-/-) zebrafish

200 Lipid metabolism in pregnancy delivers PUFAs from maternal liv

201 To better understand cholesterol metabolism in situ across the complex functional regions

202 reducing system supporting Cygb-mediated NO metabolism in SMCs with changes in cellular B5/B5R level

203 The key roles of cholesterol metabolism in the activation of inflammasomes have been

204 omarkers of inflammation, lipid, and glucose metabolism in the blood of patients with moderate-to-sev

205 host responses intersect with gut microbial metabolism in the context of gut inflammation.

206 covered an alternative pathway for carnitine metabolism in the gut bacterium Eubacterium limosum Inst

207 te the role of fructose in glucose and lipid metabolism in the liver, heart, skeletal muscle, and adi

208 human AS3MT and the rate and pattern of iAs metabolism in the wild-type and humanized mice.

209 d are required for ER-localized phospholipid metabolism in vegetative and reproductive growth.

210 CD38 mediated the eNAD metabolism in whole tissues, but CD38 did not appear to

211 kinase (AMPK), a master regulator of energy metabolism, in response to ZIKV challenge.

212 ing central pathways of mitochondrial energy metabolism, including the respiratory chain and each enz

213 Our results suggest that altered metabolism induced by SXR loss of function resulted in t

214 l metabolite measurement implicate cell wall metabolism/integrity in betaCA3-mediated basal immunity

215 dentified substantial reprogramming of tumor metabolism involving oxidative phosphorylation and fatty

216 Impaired oxygen and cellular metabolism is a hallmark of ischaemic injury in acute st

217 Microbial secondary metabolism is a reservoir of bioactive compounds of imme

218 This study demonstrates that lipid metabolism is a sensitive endpoint for the interacting e

219 e find that attractor topography of nutrient metabolism is altered in amyotrophic lateral sclerosis (

220 It now becomes clear that cell metabolism is an integral part of the complex landscape

221 Now, the study of tumour metabolism is being redefined by the development of new

222 Reprograming of proline metabolism is critical for tumor growth.

223 hanisms of how autophagy supports tumor cell metabolism is essential.

224 Circadian regulation of metabolism is largely driven by rhythmic transcriptional

225 Metabolism is one of the strongest drivers of interkingd

226 establishes that another key step in central metabolism is poisoned by molecular oxygen itself.

227 It is recognized that cell metabolism is tightly connected to other cellular proces

228 the potential to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic stea

229 creased cementum formation, suggesting PP(i) metabolism may be a target for periodontal regenerative

230 ctively demonstrate that targeting glutamine metabolism may be an effective approach for treating pat

231 is that, owing to the nature of lipoprotein metabolism, measures related to the composition of lipop

232 peutic target for treating disordered energy metabolism metabolic syndrome and type 2 diabetes.

233 ding signaling, RNA processing, translation, metabolism, nuclear integrity, protein trafficking, and

234 iological roles for NnOMT1 and NnOMT5 in BIA metabolism, occurring primarily in young leaves and embr

235 CYP4Z1-dependent metabolism of arachidonic acid preferentially generates

236 synthesis of pigments and oxylipins, and the metabolism of carbohydrates, amino acids and indol- and

237 pathways and cause defective absorption and metabolism of dietary nutrients.

238 phenotypic information, we characterized the metabolism of each isolate and tested for predicted trad

239 the gut microbiome, which contributes to the metabolism of flavonoids.

240 The metabolism of healthy murine and more recently human imm

241 This study provides a new insight into the metabolism of IVD cells under nutrient deprivation and t

242 (LDs) carry information to measure the lipid metabolism of live cells.

243 nor component of the AFFF or were formed via metabolism of other AFFF components.

244 Our results indicated that the metabolism of PROTACs could not be predicted from that o

245 In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we determine

246 view is that methanogenesis is an ancestral metabolism of the class Thermoplasmata.

247 Diet alters drugs, the metabolism of the microbiota, and the host.

248 crocompartment that spatially constrains the metabolism of the toxic intermediate lactaldehyde.

249 d the consequences of climate change for the metabolism of these organisms in the natural environment

250 , reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DNA damage.

251 MDD was associated with disorders of lipid metabolism (OR 1.22, 95% CI 1.12-1.34) and ischaemic hea

252 morphology shifts rapidly to manage cellular metabolism, organelle integrity, and cell fate.

253 hows a diversity of nutrient acquisition and metabolism pathways present that may benefit the host, a

254 , and was better associated with glutathione metabolism, providing an alternate molecularly defined b

255 ants in genes associated with glycine-serine metabolism (PSPH, PHGDH and CPS1) to be associated with

256 dysregulation of CoA-dependent intermediary metabolism rather than respiratory chain defects in the

257 Instead, serine alters E. coli's 1C-metabolism, reduces the provision of nucleotides to the

258 (2) Aberrant activation of the glucose/lipid metabolism regulator peroxisome proliferator-activated r

259 However, the central role of alpha-klotho in metabolism remains largely unexplored.

260 Indeed, targeting glutamine metabolism rendered checkpoint blockade-resistant tumors

261 In conclusion, reduction of GSL metabolism resolves the multi-organ pathology of Bbs2-/-

262 -regulation of genes involved in cholesterol metabolism, scavenger receptors, MERTK, and complement.

263 c gut microbial communities, an ex vivo drug metabolism screen, and targeted and untargeted functiona

264 torying carbon consumed and stored for urban metabolism should be given more credit for the role it c

265 ance of 6 fundamentally important processes: metabolism, signaling, electrophysiology, extracellular

266 sis and metabolic activities involving lipid metabolism, specifically the synthesis of pigments and o

267 Guided by metabolism studies, we identified compounds with reduced

268 se array of genetic disorders of cholesterol metabolism support this claim as do multiple lines of re

269 to identify the most cost-effective usage of metabolism that also best reflects the cell's investment

270 harmaceuticals induce changes in cholesterol metabolism that are similar to changes induced by geneti

271 gnificant role of sigma factors in bacterial metabolism, their rational engineering for commercial me

272 These alterations indicate improved energy metabolism through increased beta-oxidation of fatty aci

273 s a bifunctional enzyme involved in fructose metabolism through its glyceraldehyde kinase activity an

274 udy of multiple transgenes targeting primary metabolism thus offers opportunities to probe the geneti

275 lla rotation to accumulate cells and proline metabolism to counteract oxidative stress, during growth

276 athways that respond to the state of glucose metabolism to drive the morula to blastocyst transition.

277 Viruses are known to perturb host cellular metabolism to enable their replication and spread.

278 how viral oncoproteins hijack the host cell metabolism to meet their own energy demands and how this

279 efore links serine and mitochondrial alanine metabolism to membrane lipid diversity, which further se

280 s as a translatome remodeler that suppresses metabolism to shield the genome.

281 er PPARbeta/delta modulates endothelial cell metabolism to support the dynamic phenotype remains to b

282 epithelium employs comparatively glycolytic metabolism to sustain physiological citrate secretion, w

283 Oncogenic transformation alters lipid metabolism to sustain tumor growth.

284 stablished model for studies on triglyceride metabolism, to gain insight into the genes and physiolog

285 Evaluating ATM phenotype and intracellular metabolism together may more accurately illuminate the c

286 e such rhythm is a diurnal shift in symbiont metabolism triggered by the periodic provision of a spec

287 OB, a crucial monoamine oxidase for dopamine metabolism, triggers oxidative stress in dopaminergic ne

288 RNAs are associated with neurogenesis, lipid metabolism, ubiquitination, chromatin regulation and tra

289 This signaling pathway regulates lipid metabolism, unfolded protein responses, secretion of ext

290 ts, we aimed to characterize their impact on metabolism using comprehensive metabolomics data from tw

291 In this study, we found that glutamine metabolism was upregulated after EGFR activation in a GD

292 Moreover, genes associated mainly with sugar metabolism were differentially expressed in bottle gourd

293 hondrial function and fatty acid and glucose metabolism were impaired in HF-patients compared with HC

294 cytochrome P450 potentially involved in VPA metabolism were increased.

295 However, there are sexual dimorphisms in metabolism which are apparent when considering the preva

296 in droplet volume being used to measure cell metabolism, while simultaneously imaging the cells to me

297 ing glucose, cholesterol and steroid hormone metabolism with early embryonic cell movements.

298 Thereafter, a phenotypic switch to oxidative metabolism with lipid utilization to fuel invasion and m

299 e (i) review phage-mediated rewiring of host metabolism, with a focus on marine systems, (ii) conside

300 al activity is a critical component of tumor metabolism, with profound implications for tumorigenesis