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1 ules (nutrients, contaminants, or drugs) are metabolized.
2 er sugars are sequentially or simultaneously metabolized.
3 d cellobiose present in the hydrolysate were metabolized.
4 folate metabolism highly expressed in liver, metabolizes 10-formyltetrahydrofolate to produce tetrahy
6 e-nucleotide polymorphism (SNP) rs174537, to metabolize 18-carbon omega-6 (n-6) PUFAs in borage oil (
7 3'-phosphodiesterase (CNPase; an enzyme that metabolizes 2',3'-cAMP into 2'- and 3'-AMP), effects of
8 76 human gut bacteria from diverse clades to metabolize 271 orally administered drugs, that many drug
9 ow that cholesterol epoxide hydrolase (ChEH) metabolizes 5,6-EC into cholestane-3beta,5alpha,6beta-tr
10 AMX-2 is the primary monoamine oxidase that metabolizes 5-HT in C. elegans, and we also found that g
12 of this bacterium to break down, import, and metabolize a wide range of glycans is key to its virulen
15 metabolism in mice, and can explain the drug-metabolizing activities of human gut bacteria and commun
16 in ADH1B is associated with a higher alcohol metabolizing activity compared to the ancestral allele G
17 of bioavailability, host and microbial drug-metabolizing activity, drug and metabolite absorption, a
18 substrate-specific P450 with high quercetin-metabolizing activity, identified six triazole fungicide
19 also identify candidate dehydroxylases that metabolize additional host- and plant-derived catechols.
21 Fast is favored at high latitudes because it metabolizes alcohol faster, whereas Slow is favored at l
22 ral epithelial cells of Trichoplax, probably metabolizes algal lipids digested by its host and has th
24 ting that SRBs/syntrophs were instead likely metabolizing alternative substrates such as syntrophic f
25 ion was demonstrated by the ability to fully metabolize an ammonium challenge and by achieving near-n
28 ing Delta(9)-tetrahydrocannabinol (THC), are metabolized and inactivated by cytochrome P450 enzymes p
29 endogenous ligand for STING, but is rapidly metabolized and poorly membrane permeable, restricting i
33 S or some of their degradation products were metabolized, and since no organic carbon source except t
36 CYP) 2J2 is one of the CYP epoxygenases that metabolize arachidonic acid to produce epoxyeicosatrieno
37 This work suggests that mucosal cells can metabolize aroma compounds and that non-covalent interac
38 l (p < 0.05), and suggested that cells could metabolize aroma compounds from different chemical famil
39 gh syntrophs have been generally presumed to metabolize aromatic compounds to acetate, CO2 , H2 and f
41 d to 2-(methylthio)ethanol, which is further metabolized as a usable organic sulfur source, generatin
42 n two peroxisomal acyl-CoA oxidases does not metabolize ascr#18 and does not repel nematodes, indicat
47 to determine the association between sulfur-metabolizing bacteria in stool and risk of CRC over 26 y
48 ied a dietary pattern associated with sulfur-metabolizing bacteria in stool and then investigated its
49 to a dietary pattern associated with sulfur-metabolizing bacteria in stool was associated with an in
50 r studies are needed to determine how sulfur-metabolizing bacteria might contribute to CRC pathogenes
52 viduals, increasing the abundance of lactose-metabolizing bacteria that were responsive to dietary ad
57 nverting enzyme (ACE) from angiotensin I and metabolized by ACE 2 (ACE2), plays a pivotal role in the
58 biota biomass, of which a major fraction is metabolized by bacteria, thus deciphering interactions b
59 nto glucose and fructose that can be readily metabolized by C. albicans, enhancing growth and acid pr
62 anolamine and 2-arachidonoyl-glycerol can be metabolized by cyclooxygenase-2 into PG-ethanolamide (PG
67 OA occurred, some of the products were being metabolized by heterotrophs present in this culture.
68 d to eADO by ENPP1 and NT5E, (3) eNAD is not metabolized by ICC, (4) NT5E is expressed chiefly by SMC
70 lavones, such as genistein and daidzein, are metabolized by microbes to bioactive metabolites as O-de
71 hydroxyphenethylamine), which is a monoamine metabolized by monoamine oxidase (MAO), exists widely in
72 ne secreted by plant-parasitic nematodes, is metabolized by plants to generate chemical signals that
73 8,9-E-11-HET and ct-8,9-E-15-HET are further metabolized by sEH, with ct-8,9-E-11-HET being hydrolyze
76 Lactose is an abundant dietary carbohydrate metabolized by the dental pathogen Streptococcus mutans.
80 hat, in NKT cells, glucose is preferentially metabolized by the pentose phosphate pathway and mitocho
82 which interacted with OATP1B3-1B7, is highly metabolized by uridine-5'-diphospho-glucuronosyltransfer
88 drug metabolism, including those involved in metabolizing chemotherapy drugs that are commonly used i
90 ve disorder is characterized by a failure to metabolize cobalamin into adenosyl- and methylcobalamin,
92 r communication, the functional role of drug metabolizing cytochrome P450 (CYP) enzymes in human plas
96 w the pneumococcus utilizes these enzymes to metabolize different carbohydrates and how this impacts
99 most cells, while not dividing, continue to metabolize, displaying a remarkably wide diversity of me
101 the ability to extract nutrients from food, metabolize drugs, evade antibiotics, and communicate wit
107 , cytochromes P450 (P450s), are enzymes that metabolize endobiotics (physiologically active steroids
111 ypothesis that NAT1 is not just a xenobiotic metabolizing enzyme and may have a role in endogenous ce
112 assically described as a phase-II xenobiotic metabolizing enzyme but can also catalyze the hydrolysis
113 UVA was driven by the activation of estrogen-metabolizing enzyme CYP1B1 and formation of reactive est
114 ibitor DX314 has enhanced selectivity for RA-metabolizing enzyme CYP26B1 and may offer an improved tr
117 Here we show that the glycosphingolipid metabolizing enzyme glucosylceramidase is required for o
119 osuppression is the expression of tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO).
120 ion up-regulate expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1)
121 Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of infl
122 reatic cancers were dependent on the glucose-metabolizing enzyme phosphogluconate dehydrogenase (PGD)
123 ransferase 1 (NAT1) is a phase II xenobiotic-metabolizing enzyme that also has a role in cancer cell
124 amine N-acetyltransferase 1 (NAT1) is a drug-metabolizing enzyme that influences cancer cell prolifer
125 cytochrome P450 3A4 (CYP3A4), the major drug metabolizing enzyme, by dietary compounds has recently a
129 Previously known associations with alcohol-metabolizing enzymes (ADH1B, ALDH2) have been replicated
130 ding SLC and ABC "drug" transporters, "drug" metabolizing enzymes (DMEs), and regulatory genes-is ess
132 ulation of ceramide synthesizing or ceramide metabolizing enzymes and dramatically suppress tumor pro
133 ulates the expression of genes encoding drug-metabolizing enzymes and drug transporters to essentiall
134 arises from differences in abundance of drug metabolizing enzymes and transporters (DMET) among indiv
137 ctive photoswitchable inhibitors of the drug-metabolizing enzymes carboxylesterases 1 and 2 and demon
138 pigenetic miRNA regulators of the UGT2B drug-metabolizing enzymes in healthy human liver samples.
142 vironment, deciphering the mechanisms of the metabolizing enzymes is an imperative prerequisite for i
143 fold defines a large family of nucleic acid metabolizing enzymes that catalyze phosphoryl transfer r
144 duction of RA metabolism and the specific RA-metabolizing enzymes that potentiate GVHD severity are u
145 ) comprise a diverse family of phase II drug metabolizing enzymes whose shared function is the conjug
146 s (FMOs) are primarily studied as xenobiotic metabolizing enzymes with a prominent role in drug metab
147 NA damage responses, induction of xenobiotic metabolizing enzymes, and changes in sphingolipid metabo
148 n of genes encoding digestive and xenobiotic-metabolizing enzymes, and transcription factors involved
149 rotein levels, but not mRNAs levels, of EtOH-metabolizing enzymes, including alcohol dehydrogenase 1,
150 binding cassette (ABC) transporters and drug-metabolizing enzymes, many of which are also involved in
151 regnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug effica
152 by simultaneous deletion of other l-arginine-metabolizing enzymes, such as Arg2 or Nos2, demonstratin
153 denosine production by inhibiting nucleotide-metabolizing enzymes, such as ectonucleotidases CD73 and
154 s, besides genomic alterations in thiopurine metabolizing enzymes, the relapse-specific mutations of
161 nsformations accurately, focusing on nitrile metabolizing enzymes: nitrile hydratase (NHase) and amid
165 CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive eicosanoids, which e
166 Mycobacterium tuberculosis (Mtb) imports and metabolizes fatty acids to maintain infection within hum
167 dividual genes and gene networks involved in metabolizing fenbendazole (FBZ) and flunixin meglumine (
168 se and two terminal oxidases, which serve to metabolize formate and facilitate the use of oxygen as a
170 shown to bind to the promoter of the pectin-metabolizing gene beta-GALACTOSIDASE 1 (RhBGLA1), and re
174 hly expressed by follicular dendritic cells, metabolized GGG to a form that did not activate the rece
177 , the budding yeast Saccharomyces cerevisiae metabolizes glucose predominantly by glycolysis and ferm
181 glucose is limited, some pathogenic bacteria metabolize host-derived sialic acid as a nutrient source
182 olipase PLA2G6 (PNPLA9, iPLA2beta), known to metabolize Hp-PE to lyso-PE and oxidized fatty acid, in
185 vation was supported in VA-13 cells, an EtOH-metabolizing human hepatoma cell line, which displayed m
186 depolymerize fucoidan into fucose, which is metabolized in a proteome-costly bacterial microcompartm
190 gs demonstrate that methylone is extensively metabolized in rats, but MDC is the only centrally activ
191 We find that up to 30% of the glutamine is metabolized in the cytosol, primarily for nucleotide syn
193 c acid (TCA) cycle metabolites generated and metabolized in the mitochondria serve as cofactors for e
194 indicates that some aroma compounds could be metabolized in the oral cavity in an individual manner,
196 1(PON1) is an HDL-associated protein, which metabolizes inflammatory, oxidized lipids associated wit
197 mation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a
200 of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces al
206 , finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative
208 ted to identify subpopulations of cells that metabolized less drug and to correlate cell drug concent
209 Particular bacteria from the gut microbiota metabolize Levodopa (L-dopa), reducing bioavailability o
210 omonas paucimobilis, a bacterial strain that metabolizes lignin-derived aromatics, was previously ava
214 Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a
220 ighly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs.
221 ochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metabolize most drugs and have high similarities in thei
223 ning of tracer derivatives from concurrently metabolized native and uniformly labeled tracer substanc
224 ntly regulates the rate of NO consumption by metabolizing NO in an O2-dependent manner with decreased
227 ent advances have revealed that enzymes that metabolize or modify endogenous nucleic acids are essent
229 g ATP or NAD(+), some purinergic ectoenzymes metabolize other inflammatory modulators, notably lysoph
230 obacter formigenes because of its ability to metabolize oxalate, and its potential contribution to pr
233 ains differ greatly in their capabilities of metabolizing peptides physiologically, providing insight
234 he primary outcome was the amount of glucose metabolized per kilogram of body weight per minute (Mbw)
235 nisms have developed efficient mechanisms to metabolize peroxides, mostly based on two kinds of redox
236 eatment samples may be a nonstaining, slowly metabolizing phenotype better adapted to airborne transm
237 re facultative aerobes, with some capable of metabolizing phytoplanktonic organosulfur compounds incl
238 Insect herbivores are frequently reported to metabolize plant defense compounds, but the physiologica
239 Furthermore, reflecting the reduced need to metabolize plant-derived xenobiotics, several carnivores
240 t a potential role of primarily endogenously metabolized plasma phospholipid n-6 PUFAs including GLA,
242 cytosolic carboxypeptidase (CCP) family that metabolizes polyglutamate side chain and its loss result
247 purine release mechanisms, ectoenzymes that metabolize purines (CD38, CD39, CD73, ENPP1, and ENPP2/a
251 ors reduce chick survivorship as they cannot metabolize saline water, which makes suitable freshwater
252 emerging C. difficile species, selected for metabolizing simple dietary sugars and producing high le
253 g the ability of the human gut microbiome to metabolize small molecule drugs: Microbiome-Derived Meta
254 etabolism during the process of migration to metabolize stored lipids and fuel invasive migration.
255 genic bacterial species Streptococcus mutans metabolizes sucrose to initiate biofilm formation on the
259 on cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2',2'-
261 acteria dwelling in an animal's scent glands metabolize the glands' primary products into odorous com
262 gut bacteria orchestrate manifold enzymes to metabolize the most challenging glycan in the human diet
263 ct host defences and help to accommodate and metabolize the relatively large quantity of blood upon f
264 O reductase that can distinguish between and metabolize the two major LMW-SNO signaling molecules GSN
266 be accounted for by the finding that Cyp2c44 metabolized the PG precursor, PGH(2) to 12(S)-hydroxyhep
267 ty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-like endocannabinoid anandamide
268 ha-carboxyl-linked glutamates, CCP5 uniquely metabolizes the gamma-carboxyl linked, branch point glut
270 ori, and that spermine oxidase (SMOX), which metabolizes the polyamine spermine into spermidine plus
272 urons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP),
273 drugs mericitabine and sofosbuvir, which get metabolized to 2'-fluoro-2'C-methylcytidine-5'-triphosph
274 alysis revealed that PCB 51 and PCB 102 were metabolized to 2,2',4,6'-tetrachlorobiphenyl-3'-ol (OH-P
275 zed to [1-(13)C]-l-alanine, and subsequently metabolized to [1-(13)C]lactate and [(13)C]bicarbonate.
277 derives from placental progesterone that is metabolized to androsterone in nontesticular tissues.
279 ) with SMCs and PDGFRalpha(+) cells, eNAD is metabolized to eADO by ENPP1 and NT5E, (3) eNAD is not m
281 a major fraction of the absorbed compound is metabolized to inactive glucuronides, resulting in poor
285 single doses of furosemide and famciclovir (metabolized to penciclovir), we calculated their kidney
288 sialic acid inhibitors are more efficiently metabolized to their active cytidine monophosphate analo
289 e added to X. autotrophicus cell extracts is metabolized to trimetaphosphates, supporting the presenc
290 Carnitine, a molecule found in red meat, is metabolized to trimethylamine (TMA) by the gut microbiot
291 S precursor may be accumulating in biota and metabolizing to PFBS, leading to a higher than expected
292 otorespiration is required in C(3) plants to metabolize toxic glycolate formed when ribulose-1,5-bisp
295 Besides being oxidized, glucose was mainly metabolized via glycerol production and release and lipi
298 tests, the zwitterionic PFAS compounds were metabolized within 10 days to PFOA/PFOS at yields of 3.4