ライフサイエンスコーパス: metabolome

1 processes drove the observed changes in the metabolome.

2 cognition occurred via sensing of the cancer metabolome.

3 ime-related effects on the polar fraction of metabolome.

4 is associated with changes in the human milk metabolome.

5 which is carried through to the level of the metabolome.

6 the combined results to represent the whole metabolome.

7 licits widespread changes in the circulating metabolome.

8 tool in the investigation of the human fecal metabolome.

9 gut microbiota profoundly affected the host metabolome.

10 tion of efforts to mine the fungal secondary metabolome.

11 edation have a direct consequence on the gut metabolome.

12 ting a connection between the microbiome and metabolome.

13 f the proinflammatory and proresolving lipid metabolome.

14 rsive cues and to induce changes in the head metabolome.

15 to deliver greater representation across the metabolome.

16 from cell anatomy, to the transcriptome, and metabolome.

17 a fast approach for global profiling of the metabolome.

18 werful technique for studies of proteome and metabolome.

19 methods are needed to characterize the human metabolome.

20 ways of particular relevance to the salivary metabolome.

21 subsequent phenotypic changes in the plants' metabolome.

22 try (MS), access only a small portion of the metabolome.

23 o main clusters using 178 preoperative serum metabolomes.

24 y intestinal microbial communities and cecal metabolomes.

25 ry to reveal underlying mechanisms governing metabolomes.

26 ese were accompanied by differences in fecal metabolomes.

27 formance was evaluated based on the complete metabolome (11 385 components), whereby 76.8% was found

28 Urine metabolomes also differed significantly between patients

29 Long-term metabolome alterations continued even after withdrawal o

30 Metabolome-AMD associations were studied using univariat

31 coupled with mass spectrometry have enabled metabolome analyses for clinical cohorts.

32 ome, transcriptome, epigenome, proteome, and metabolome analyses to gastroenterology and hepatology r

33 Similarly, metabolome analysis by mass spectrometry, shows that sil

34 ito-AP is also compatible with mitochondrial metabolome analysis by triple-quadrupole and orbitrap ma

35 Fecal metabolome analysis can be used to distinguish patients

36 Whole metabolome analysis of 20 human primary AML showed that

37 Transcriptome and metabolome analysis revealed changes in pathways involve

38 The metabolome analysis revealed differential expression of

39 Here we describe how metabolome analysis was used to identify the A. lumbrico

40 (LC-MS) is a powerful technique for in-depth metabolome analysis with high quantification accuracy.

41 sts relationships between the nasopharyngeal metabolome and both the microbiota and severity of bronc

42 sites according to overall impact on the ZFL metabolome and found that neither the total number of or

43 minutum on the host transcriptome, proteome, metabolome and host growth and asexual reproduction.

44 present an alternative way of modulating the metabolome and malignant cell behavior in melanoma.

45 mlines the integrative data analysis between metabolome and microbiome, from data preprocessing, univ

46 ns relevant to asthma between the intestinal metabolome and other "omics": the intestinal microbiome

47 broad resource on the dynamics occurring in metabolome and proteome during oocyte maturation.

48 Major global shifts in metabolome and proteome occurred upon DHFR inactivation,

49 d, as correlations between the microbial VOC metabolome and specific bacterial pathogens have been id

50 aimed to elucidate the impact of a WD on the metabolome and the gut microbiota of male and female mic

51 nt interrelationships between the intestinal metabolome and the intestinal microbiome, plasma metabol

52 In this work, the comprehensive polar metabolome and the volatile organic compounds of T. mela

53 posity-related differences in the human milk metabolome and to identify metabolites associated with i

54 e first holistic approach onto Ziziphus leaf metabolome and to include the first report of several no

55 Here, metabolome and transcriptome analyses of anthers from mu

56 thogonal approach for parsing the microbiota metabolome and uncover multiple biologically relevant ho

57 e significant differences in urine and fecal metabolomes and fecal microbiome vs control individuals,

58 s and 16S rRNA gene sequencing, plasma/urine metabolomes and the fecal microbiota of Angus steers gra

59 cillus Moreover, both leaf and systemic root metabolomes and transcriptomes change according to the r

60 vides a way to focus attention on which meta-metabolomes and which parts of meta-metabolomes are most

61 abidopsis thaliana) transcriptome, secondary metabolome, and aphid performance.

62 xteen carbons), both components of the human metabolome, and characterize their formulation into poro

63 bolome and the intestinal microbiome, plasma metabolome, and diet in association with childhood asthm

64 much less explored than the plasma and urine metabolome, and in order to generate comparable data acr

65 clinical centers in four countries, profiled metabolome, and measured concentrations of ascorbic acid

66 changes caused deficits in trafficking, the metabolome, and neuronal physiology.

67 ing longitudinal data on the gut microbiome, metabolome, and other measures.

68 Finally, we found that metabolome- and metagenome-based classifiers of IBD stat

69 etary prebiotics (Test diet) alter the fecal metabolome; and explored if these changes were related t

70 n microbial function, reflected in the fecal metabolome, appear to be more precise indicators of dise

71 dian and wake-dependent changes in the human metabolome are critical for understanding and treating h

72 LOAD patients' macrophage transcriptome and metabolome are deregulated.

73 Prior to EEN, microbiota and metabolome are different between responders and non-resp

74 ic effects of noise exposure on the cochlear metabolome are poorly understood.

75 Environmental metabolomes are fundamentally coupled to microbially-lin

76 ich meta-metabolomes and which parts of meta-metabolomes are most likely to be important to consider

77 ome, and the consequences for the early life metabolome, are just starting to be defined.

78 red by using 16S rRNA sequencing, the plasma metabolome as measured by using mass spectrometry, and d

79 ucumber plants adapt their transcriptome and metabolome as result of spider mite infestation with opp

80 emonstrates that being judged older by one's metabolome, as compared with one's chronological age, co

81 imed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-

82 degeneration (AMD) by performing the largest metabolome association analysis in AMD to date, as well

83 Microbiome-metabolome association studies have experienced exponent

84 the genetic and molecular bases of rice seed metabolomes at different developmental stages is still l

85 data documenting differences in the vaginal metabolome between CT+, CT+/MG+ and uninfected women.

86 e, including genomes, gut microbiomes, blood metabolomes, blood proteomes, clinical chemistries, and

87 Fecal metabolomes, but not microbiomes, could distinguish pati

88 e potential of expanding the coverage of the metabolome by detecting phosphorus-containing metabolite

89 We profiled metabolomes by mass spectrometry from children's plasma

90 undamental role in host health and the fecal metabolome can be analysed to assess microbial activity

91 Here, we have investigated whether serum metabolome can provide useful biomarkers in the diagnosi

92 The method was applied to monitor short-term metabolome changes in HBM composition within individual

93 ectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotro

94 Metabolome changes were related to the plankton group co

95 ing UPLC-QTOF-MS/MS was performed for plasma metabolome comparison.

96 lic rhythms in human biology, as well as pan-metabolome consequences of sleep disruption.

97 The serum metabolome contains a plethora of biomarkers and causati

98 n be used to annotate which compounds in the metabolome could have been produced by bacteria present

99 extraction strategy remarkably improves the metabolome coverage beyond that of conventional data pre

100 metabolic features, thus hindering complete metabolome coverage from the analysis.

101 echniques have been developed for increasing metabolome coverage in direct sampling workflows.

102 In short, this study has shown that high metabolome coverage is theoretically attainable by analy

103 we explored the possibility of enhancing the metabolome coverage of data-dependent liquid chromatogra

104 lume-restricted blood specimens that expands metabolome coverage to encompass anionic classes of lipi

105 This analytical approach allows extensive metabolome coverage, especially for low-abundance glycer

106 ques and analytical platforms to obtain high metabolome coverage.

107 performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as change

108 hat can effectively integrate microbiome and metabolome data to derive biological insights.

109 hrough integrated analysis of microbiome and metabolome data, mechanistic relationships between micro

110 tra from the Golm Metabolome Database, Human Metabolome Database, and FiehnLib were used for testing

111 Spectra from the Golm Metabolome Database, Human Metabolome Database, and Fieh

112 ior to adverse manifestations, we utilized a metabolome dataset of 228 nuclear-magnetic-resonance-mea

113 that UV-B has a strong impact on peach flesh metabolome, determining an initial decrease after 24 h,

114 Microbiota and metabolome differed between responders and non-responder

115 Overall metabolome differences between populations suggest that

116 re, we aimed to evaluate whether the vaginal metabolome discriminates the presence/absence of MIAC in

117 In the case study of the platelet metabolome during storage, the new visualization techniq

118 as to explore the changes in serum and urine metabolomes during postprandial dairy product tests thro

119 hesis between ecology and metabolomics 'meta-metabolome ecology' and demonstrate its utility using a

120 at multiple levels, including transcriptome, metabolome, enzyme activities, product accumulation, and

121 Children's plasma metabolome, especially lipidome, reflects gene regulatio

122 tabolomic samples were collected using RApid Metabolome Extraction and Storage (RAMES) technology, wh

123 mics, and 60 fecal samples were analyzed for metabolome features.

124 ultaneous characterization of the endogenous metabolome, food-related metabolites, pharmaceuticals, h

125 and enrollment procedures, collection of the metabolomes for UDN patients took place over 2 years.

126 earch is to optimize extraction of the fecal metabolome from adult and baby pandas for high throughpu

127 d analyses of brain transcriptomes and blood metabolomes from human apoE2-, apoE3-, and apoE4-targete

128 tematic MS/MS- and NMR-based analysis of exo-metabolomes from over 30 Pristionchus species.

129 ic pathways, we profiled plasma and cortical metabolomes from Ube3b (-/-) mice.

130 g with a metabolomic analysis of the urinary metabolome, from subjects with an active episode of USD

131 Moreover, targeting LTC(4)S increases CTR metabolomes, giving a new strategy to stimulate resoluti

132 host and microbe-associated shifts in fecal metabolomes had the potential to distinguish patients wi

133 al multi-omics data from the gut microbiome, metabolome, host epigenome, and transcriptome in the con

134 analysis of gut microbiome, serum bile acid metabolome, imaging, and histological measurements in cl

135 (CTRL) (n = 7) to investigate changes of the metabolome, immunohistochemistry and protein levels.

136 e evaluated the gut microbiome, proteome and metabolome in 88 African-American newborns using faecal

137 eptor ligands, cytosine methylation, and the metabolome in both the induction and mitigation of epibo

138 ers of liver injury and alterations in serum metabolome in children.

139 proteins and ligands, we define the lipidome/metabolome in contact with membrane porins and a mitocho

140 erstudied and the composition of the vaginal metabolome in CT/MG co-infected women is unknown.

141 tecting differences in the polar fraction of metabolome in dry-aged and wet-aged beef over the aging

142 d to the investigation of the changes in the metabolome in human plasma for patients with injury to t

143 dy to date demonstrate the role of the urine metabolome in identifying at-risk persons for T2D and su

144 onship between genetic factors and the urine metabolome in kidney disease.

145 Little is known about the role of the urine metabolome in predicting the risk of T2D.

146 Examining the vaginal metabolome in the context of CT mono (CT+) and CT/MG co-

147 Yet, the vaginal metabolome in the setting of CT infection is understudie

148 ctroscopy and UHPLC-MS) to probe the urinary metabolome in-depth in people with Alzheimer's Disease a

149 microbiota correlated and co-varied with the metabolomes in a THI-dependent manner.

150 potential application of preoperative serum metabolomes in predicting recurrence in patients with re

151 time-resolved transcriptomes, lipidomes and metabolomes in response to nitrogen deprivation.

152 ical metabolic environment of the gut (fecal metabolome) in approximate agreement with the real data.

153 tional change but significant changes to the metabolome, including a large number of changes in ascar

154 The blood metabolome incorporates cues from the environment and th

155 rRNA gene sequencing, was predictive of the metabolome, indicating a connection between the microbio

156 In this study, an automated microbiome and metabolome integrative analysis pipeline (M2IA) has been

157 nce of E+ grazing and +THI on the microbiota:metabolome interactions.

158 ltiple biologically relevant host-microbiota metabolome interactions.

159 olism, especially in relation to the hormone-metabolome interface and its subsequent physiological an

160 isolated and used to perform transcriptome, metabolome, intracellular calcium, extracellular catheps

161 The metabolome is a collection of exogenous chemicals and me

162 nteresting alternative because its intrinsic metabolome is chemically diverse and reflective for vari

163 The human faecal metabolome is complex, but rich in information and allow

164 dized mixed meal showed that the human serum metabolome is remarkably stable: The median intra-class

165 The faecal metabolome is still much less explored than the plasma a

166 By examining the salivary metabolome, it is clear that protein degradation is a ke

167 peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcript

168 me (16S rRNA gene sequencing), cytokine, and metabolome (liquid chromatography tandem mass spectromet

169 s CD-TREAT) on fecal microbiome composition, metabolome, mean total sulfide (increase 133.0 +/- 80.5

170 egrated gut microbiome, host genetics, urine metabolome, measures of physiology and anthropometrics m

171 g genome, immunome, transcriptome, proteome, metabolome, microbiome and wearable monitoring.

172 both stress and Test diet altered the fecal metabolome/microbiome.

173 The circulating metabolome might reflect pathophysiological events relat

174 t adversely impact the representativeness of metabolome obtained ex vivo, and further evidence that l

175 employed to capture real-time changes in the metabolome of 'Honeycrisp' apples during ripening on the

176 Herein, we compared the global metabolome of 231 plasma and 97 fecal samples from a lar

177 ealthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant

178 the most appropriate for studying the fecal metabolome of adult and baby giant pandas respectively.

179 pectroscopy was used to identify the primary metabolome of Aglianicone grape pulp from two different

180 Here, we unraveled the metabolome of an H3K4 demethylase (KDM5B/JARID1B)-driven

181 ffects of elevated auxin and ethylene on the metabolome of Arabidopsis roots using a high-resolution

182 geted integrative analysis of the intestinal metabolome of childhood asthma in this ancillary study o

183 samples and urine were very similar but the metabolome of DBS included additional metabolites not de

184 al Salmonella carriage on the microbiome and metabolome of developing young layer chicks.

185 microbiome was moderate; however, the fecal metabolome of EF-fed infants showed a significant reduct

186 dagrass, ectoparasites can modify the global metabolome of host plants.

187 3B1 altered the transcriptome, proteome, and metabolome of human cells, leading to missplicing-associ

188 nabled statistical analyses to summarize the metabolome of individual patients.

189 y, we characterized the fecal microbiome and metabolome of infants fed a bovine MFGM supplemented exp

190 on surface sampling probe, for analyzing the metabolome of live microglial cells by drift-tube ion mo

191 e (MeJA) and by compounds upregulated in the metabolome of MeJA-treated Arabidopsis leaves, on the br

192 used LC-MS-based metabolomics to examine the metabolome of MYC-expressing cells upon AHR knockdown.

193 We intend to characterize the metabolome of never smoking WTC-exposed firefighters, st

194 Microbiota and metabolome of patients with CD and controls were differe

195 The secondary metabolome of Penicillium nordicum is poorly documented

196 ome, transcriptome, microbiome, proteome and metabolome of samples obtained simultaneously from the s

197 o separately analyze the polar and non-polar metabolome of the cocoa testa (cocoa shell) and the coco

198 The metabolome of World Trade Center (WTC) particulate matte

199 re ideal platforms for rapidly analyzing the metabolomes of biological specimens.

200 on of genomes, transcriptomes, proteomes and metabolomes of CAM plants and efforts are ongoing to eng

201 Studies on metabolomes of carcinogenic pollutants among children an

202 g to characterize the vaginal microbiota and metabolomes of CT+, CT+/MG+, and uninfected women.

203 Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

204 The metabolomes of DUS samples and urine were very similar b

205 We examined the serum metabolomes of five mother and pup pairs of Atlantic gre

206 This system was used to compare the secreted metabolomes of human monocyte-derived macrophages (hMDM)

207 st Squares-Discriminant Analysis (PLS-DA) of metabolomes of individual plants allowed statistical sep

208 ng, we analyzed age-dependent changes in the metabolomes of long-lived Drosophila melanogaster.

209 RBs remodels the rhythmic transcriptomes and metabolomes of multiple cell types within the liver.

210 ass spectrometry metabolomics to analyze the metabolomes of the 282 maize inbred lines in the Goodman

211 ut microbiota are mediated via the microbial metabolome, or the collection of small-molecule metaboli

212 mplex links between genomes, transcriptomes, metabolomes, organisms, and ecosystem functions in coral

213 ra-individual variability of the human serum metabolome over a period of 4 weeks and its dependence o

214 ve cancer antigen (CA) 19-9 levels and serum metabolomes PC.aa.C38_4, PC.ae.C42_5, and PC.ae.C38_6 we

215 Analysis of the systemic root metabolome points to glycosylated azelaic acid as a pote

216 gut microbiome alters the microbiome-derived metabolome, potentially promoting carcinogenesis in orga

217 In the periphery, APOE2 drove distinct blood metabolome profile highlighted by the upregulation of li

218 We aimed to examine metabolome profiles and their association with more-seve

219 Fecal metabolome profiles could discriminate patients with IBS

220 Serum metabolome profiles differed by bronchiolitis severity (

221 Proteome and metabolome profiles in dry nced2569 seeds, compared with

222 Microbiome and metabolome profiles of mice harboring human microbiota p

223 Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo matu

224 ssissippi Canyon 252 oil on plasma and liver metabolome profiles of the double-crested cormorant (Pha

225 ent investigation, the relative proteome and metabolome profiles of the non-transformed wild-type and

226 essors, photosynthesis and transcriptome and metabolome profiles of wild-type and knockdown lines.

227 Comparisons of transcriptome and metabolome profiles suggest a strong impact of AOX activ

228 ormula-fed- like infant fecal microbiome and metabolome profiles.

229 ddress this issue, we performed proteome and metabolome profiling as well as mitochondrial whole-exom

230 of interest that demonstrate the utility of metabolome profiling for rare diseases.

231 Importantly, metabolome profiling in mycobacteria reveals a significa

232 A population of interest for metabolome profiling is patients with rare disease for w

233 We undertook the metabolome profiling of a large cohort of patients with

234 Metabolome profiling of cecal contents in antibiotic-ind

235 In this study, we performed proteome and metabolome profiling of chRCC tumors and adjacent kidney

236 In this study, transcriptome, proteome and metabolome profiling was used to document the responses

237 to report results from the Children's Autism Metabolome Project (CAMP), a large-scale effort to defin

238 In assessment of the metabolome, prominent subpathways included advanced glyc

239 The human metabolome provides a window into the mechanisms and bio

240 ekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for un

241 Variation in levels of the human metabolome reflect changes in homeostasis, providing a w

242 The intestinal metabolome reflects the biological consequences of diver

243 the strongest associations with the specific metabolome related to infant adiposity.

244 options for mitochondrial diseases, such as metabolome remodeling.

245 The red-light-modulated guard cell metabolome reported here provides fundamental informatio

246 lia polarization, we highlight cell-specific metabolome reprogramming as a promising non-gene-specifi

247 unknown insights into the dynamic aspects of metabolome reprogramming in the growth phases of Colleto

248 The findings show that the root metabolome responds rapidly to hormone stimulus and that

249 effects of CO(2) and Fe availability on the metabolome response of a natural phytoplankton community

250 allele enabled analysis of transcriptome and metabolome responses to incipient biotin deficiency in s

251 Here, we studied the grain transcriptome and metabolome responses to postanthesis N and S supply for

252 vealed extensive alterations in the cellular metabolome resulting from overexpression of N-Myc.

253 ers increased chemical space coverage of the metabolome, resulting in faster and more accurate assign

254 lled nitrate, ammonium, and urea through the metabolome revealed N uptake, regardless of species, was

255 eterogeneous in both disease states, but the metabolome reveals disease-specific patterns.

256 AhR activation on hepatic transcriptome and metabolome rhythmicity in male C57BL/6 mice orally gavag

257 zed treatment with oral HT resulted in large metabolome shifts that generally favored CEE alone over

258 Genome and metabolome showed evidence of adaptation consistent with

259 The T2DM heart metabolome showed significant differences in the abundan

260 Integrated analysis of the transcriptome and metabolome showed the used of alternate energetic pathwa

261 stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 mo

262 de (NAD) levels, and an imbalance in the NAD metabolome that includes elevated CD38 NADase and reduce

263 logistic regression model based on the fecal metabolome that is able to distinguish between patients

264 xalate, associates with perturbations of the metabolome that may be upstream determinants of early-on

265 The study of the metabolome, the collection of all the small molecule met

266 es in the gut microbiota, changes in the gut metabolome-the molecular interface between host and micr

267 nome, transcriptome, epigenome, proteome and metabolome, thereby providing copious resources for canc

268 ietary phytochemicals belonging to the plant metabolome, they are not entirely relevant to human heal

269 d support integrative analyses that link the metabolome through the proteome to the transcriptome and

270 ased association analysis linking the cancer metabolome to genetic alterations, epigenetic features a

271 cterized changes in the fecal microbiota and metabolome to identify the mechanism of EEN.

272 The ability of the blood metabolome to predict gut microbiome alpha-diversity cou

273 be categorized according to their different metabolomes to predict early cancer recurrence.

274 rt due to their ability to modify host plant metabolomes to their benefit.

275 ed to investigate whether the maternal serum metabolome together with clinical factors could be used

276 In parallel, analyses of bacterial metabolomes typically assign chemical structures to only

277 the temporal variability of the human serum metabolome under such tightly controlled conditions.

278 ssing methods for measuring the human faecal metabolome using proton nuclear magnetic resonance ((1)H

279 rmal processing on the Ceratonia siliqua pod metabolome was assessed by mass spectrometry (MS)-based

280 The tryptophan metabolome was determined by liquid chromatography-tande

281 The global serum metabolome was determined in those resistant to WTC-LI a

282 effects of pickling on Egyptian olive fruit metabolome was determined using mass spectrometry-based

283 Moreover, the berries pulp metabolome was related to Apparent Electrical Conductivi

284 To investigate the secreted metabolome, we developed a novel workflow consisting of

285 Within the KDM5B-dependent metabolome, we found significant and highly specific reg

286 Various behaviors, gut microbiota, and fecal metabolome were assessed at 90 days of age.

287 Fecal microbiome and metabolome were assessed before and after each diet.

288 These alterations in the metabolome were not directly predicted by the correspond

289 HT effects on the metabolome were profound; 62% of metabolites significant

290 nt regimen, and their combined impact on the metabolome were studied using HPLC-ESI-QTOF-MS analysis

291 Stool metabolomes were analyzed using ultra-high-performance l

292 e intracellular and extracellular (secreted) metabolomes were extracted with methanol and subjected t

293 ificant differences in their volatile faecal metabolome when compared to their respective WT litterma

294 Here, we focused on the metabolome, which represents the most proximal link betw

295 rior to characterization of the human muscle metabolome, which resulted in the identification and qua

296 hanges in metabolites should be investigated metabolome-wide after "Sweating".

297 A metabolome-wide approach revealed that this hybrid is mo

298 in the Young (TEDDY) study aimed to identify metabolome-wide signals preceding the first IA against G

299 in significant alterations in the bile acid metabolome with little to no changes in gut microbial co

300 phage phenotypes considerably affects the LM metabolomes with potential consequences for inflammation