ライフサイエンスコーパス: metallo

1 The use of Turbo Grignard generated the metallo-2-pyridyl intermediate more reliably than alkyll

2 artic, ~19% (44/233) cysteine, ~40% (93/233) metallo, ~28.3% (66/233) serine and ~6.4% (15/233) threo

3 , ~8% (12/150) are cysteine, ~58.7% (88/150) metallo, 30% (45/150) serine and ~3.3% (5/150) are threo

4 cribes the fabrication of electropolymerized Metallo 4', 4'', 4''', 4'''' tetra-amine phthalocyanine

5 to add further insight into the chemistry of metallo-Abeta, which may assist better understanding of

6 The metallo-activated complexes of all of these compounds we

7 An ABC transporter with a periplasmic metallo-aminopeptidase domain forms a sensory complex wi

8 lyze two genetically essential P. falciparum metallo-aminopeptidases (MAPs), PfA-M1 and Pf-LAP.

9 M1 family metallo-aminopeptidases fulfill a wide range of critical

10 a parasite Plasmodium falciparum employs two metallo-aminopeptidases, PfA-M1 and PfA-M17, which are e

11 es may reflect an evolutionary adaptation of metallo and nonmetallo KDO8PS's to the cellular concentr

12 ctronic similarities and differences between metallo- and organic OPEs can be understood largely on t

13 Key similarities between the metallo- and organic OPEs that bear on materials-related

14 dothelial cells in the presence of the major metallo- and serine protease systems that modified peric

15 chemistry related areas: molecular switches, metallo-assemblies and sensors.

16 lso can be used to detect the formation of a metallo-base pair within a duplexed strand and is theref

17 nally high kinetic stabilities of T-Hg(II)-T metallo-base pairs (half-lives = 0.3-1.3 h) perturbed dy

18 Three 3' cytosine metallo-base pairs stabilize a parallel A-form-like dupl

19 actions of PqqB are unprecedented within the metallo beta-lactamase protein family and expand the cat

20 hibit L2 (serine beta-lactamase) but not L1 (metallo beta-lactamase) from the extensively drug resist

21 Metallo beta-lactamases (MbetaL) are enzymes naturally e

22 tly discovered inhibitors of serine and some metallo beta-lactamases.

23 ored K. pneumoniae carbapenemase (56.1%), 54 metallo-beta-lactamase (40.9%), and four both (3.0%).

24 umoniae carbapenemase (blaKPC) and New Delhi metallo-beta-lactamase (blaNDM) genes.

25 ch X-ray absorption spectroscopy of a dizinc metallo-beta-lactamase (MbetaL) reaction intermediate.

26 hETHE1 is a mono-iron binding member of the metallo-beta-lactamase (MBL) fold superfamily.

27 ontaining a motif related to the prokaryotic metallo-beta-lactamase (MBL) fold.

28 olate had VIM-2 and IMP-18, and 7 carried no metallo-beta-lactamase (MBL) gene.

29 Metallo-beta-lactamase (MBL) inhibitors can restore the

30 The metallo-beta-lactamase (MBL) is a candidate protein fami

31 atened by the emergence and global spread of metallo-beta-lactamase (MBL) mediated resistance, specif

32 Members of the metallo-beta-lactamase (MBL) superfamily of enzymes harb

33 ation of the antimicrobial susceptibility of metallo-beta-lactamase (MBL)-harboring Enterobacteriacea

34 Metallo-beta-lactamase (MBL)-producing CRE have recently

35 robacteriaceae (CRE) producing the New Delhi metallo-beta-lactamase (NDM) are rare in the United Stat

36 New Delhi metallo-beta-lactamase (NDM) represents a serious challe

37 cal data to analyze an outbreak of New Delhi metallo-beta-lactamase (NDM)-producing K. pneumoniae tha

38 Infections caused by New Delhi metallo-beta-lactamase (NDM)-producing strains of multid

39 The New Delhi metallo-beta-lactamase (NDM-1) is involved in the emergi

40 emase (IMP)-producing (n = 22) and Sao Paulo metallo-beta-lactamase (SPM)-producing (n = 14) isolates

41 apenemase (KPC), and Verona integron-encoded metallo-beta-lactamase (VIM) were the most common carbap

42 nically relevant MBL Verona integron-encoded metallo-beta-lactamase (VIM-2).

43 the recently described antibiotic-resistant metallo-beta-lactamase 1 Klebsiella pneumoniae.

44 Metallo-beta-lactamase activity is thought to be polyphy

45 istronic operon (blhA-orfY), which encodes a metallo-beta-lactamase and a coenzyme A-disulfide reduct

46 -processing endonuclease CPSF-73, containing metallo-beta-lactamase and beta-CASP domains and a clust

47 se production but also distinguishes between metallo-beta-lactamase and serine-carbapenemase producti

48 re, mechanism, and biochemical properties of metallo-beta-lactamase Bla2 from Bacillus anthracis, the

49 re found to carry the recently characterized metallo-beta-lactamase blaSPR-1 that, although not confe

50 information available on early stage dizinc metallo-beta-lactamase catalysis.

51 c features of the catalytic action of dizinc metallo-beta-lactamase CcrA from Bacteroides fragilis.

52 In an effort to probe Co(II) binding to metallo-beta-lactamase CcrA, EPR, EXAFS, and (1)H NMR st

53 cturally and mechanistically very similar to metallo-beta-lactamase CcrA.

54 a-lactamases and less so against the class B metallo-beta-lactamase CcrA.

55 CPSF-73 and CPSF-100 contain two domains, a metallo-beta-lactamase domain and a novel beta-CASP (nam

56 odes a protein containing a highly conserved metallo-beta-lactamase domain, within which our swip-10

57 l library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification

58 se RNase J, a member of the widely occurring metallo-beta-lactamase enzyme family.

59 opening (AHL lactonases) are members of the metallo-beta-lactamase enzyme superfamily and rely on a

60 o beta-lactam antibiotics can be mediated by metallo-beta-lactamase enzymes (MBLs).

61 Metallo-beta-lactamase enzymes are encoded on highly tra

62 Bacteria use metallo-beta-lactamase enzymes to hydrolyse lactam rings

63 road-spectrum inhibitors of both serine- and metallo-beta-lactamase enzymes.

64 vii) delta genomes encode multiple copies of metallo-beta-lactamase enzymes; (viii) a host of secreti

65 ssay, the boronic acid synergy test, and the metallo-beta-lactamase Etest, had specificities of >90%

66 at similar or identical endonucleases of the metallo-beta-lactamase family generate the 3' ends of po

67 Pso2/Snm1 is a member of the beta-CASP metallo-beta-lactamase family of proteins that include t

68 tRNase Z, a member of the metallo-beta-lactamase family, endonucleolytically remov

69 e class of these enzymes is a zinc-dependent metallo-beta-lactamase for which there are no clinically

70 nem- and cephamycin-resistant dinuclear zinc metallo-beta-lactamase from Bacteroides fragilis and its

71 ve, estimating a lower bound of evidence for metallo-beta-lactamase functionality but not an upper bo

72 , given that ancestral proteins may have had metallo-beta-lactamase functionality with variation in s

73 of these models conform to our criteria for metallo-beta-lactamase functionality, suggesting that th

74 and metal substituted Bacillus cereus (BcII) metallo-beta-lactamase have been investigated.

75 lts give the first structural information on metallo-beta-lactamase ImiS and suggest that the second

76 dy of a spin-labeled variant of the class B2 metallo-beta-lactamase ImiS identified movement of a com

77 nterobacteriaceae strain harboring the NDM-1 metallo-beta-lactamase in a pediatric patient in the Uni

78 ted with the nonoutbreak spread of New Delhi metallo-beta-lactamase in diverse Enterobacteriaceae spe

79 The designed metallo-beta-lactamase is functional in the Escherichia

80 an effort to further probe metal binding to metallo-beta-lactamase L1 (mbetal L1), Cu- (Cu-L1) and N

81 effort to probe whether the metal content of metallo-beta-lactamase L1 is affected by metal ion bioav

82 he structure of the reaction intermediate of metallo-beta-lactamase L1 when reacted with nitrocefin a

83 ort to probe the role of the Zn(II) sites in metallo-beta-lactamase L1, mononuclear metal ion contain

84 s with the preparation of Co(II)-substituted metallo-beta-lactamase L1, two strategies were undertake

85 characterize the roles of each metal ion in metallo-beta-lactamase NDM-1, heterodimetallic analogues

86 In an effort to biochemically characterize metallo-beta-lactamase NDM-1, we cloned, overexpressed,

87 Artemis is a member of the metallo-beta-lactamase protein family of nucleases.

88 ARTEMIS is a member of the metallo-beta-lactamase protein family.

89 e highest-resolution structural data for any metallo-beta-lactamase reported to date.

90 Metallo-beta-lactamase screening tests were positive, PC

91 This marks the first preparation of a metallo-beta-lactamase selectively substituted with a pa

92 ng Escherichia coli cells carrying New Delhi metallo-beta-lactamase subclass 1 (NDM-1) can be monitor

93 Escherichia coli cells expressing New Delhi metallo-beta-lactamase subclass 1 (NDM-1), an emerging a

94 These enzymes are members of the metallo-beta-lactamase superfamily and contain two zinc

95 ts subunit 11 (IntS11), which belongs to the metallo-beta-lactamase superfamily and is a paralog of C

96 ese AHL lactonases have been assigned to the metallo-beta-lactamase superfamily of proteins, which in

97 se of their relation to other enzymes in the metallo-beta-lactamase superfamily.

98 which are metalloproteins that belong to the metallo-beta-lactamase superfamily.

99 CphA is a Zn(2+)-dependent metallo-beta-lactamase that efficiently hydrolyzes only

100 Insidious coproduction of metallo-beta-lactamase with KPC-type carbapenemase has i

101 superfamilies, including the amidohydrolase, metallo-beta-lactamase, and enolase superfamilies.

102 effort to probe the structure of a group Bb metallo-beta-lactamase, Co(II)-substituted ImiS was prep

103 Here we report an artificial metallo-beta-lactamase, constructed via the self-assembl

104 mase domain and a novel beta-CASP (named for metallo-beta-lactamase, CPSF, Artemis, Snm1, Pso2) domai

105 to understand the reaction mechanism of a B2 metallo-beta-lactamase, steady-state and pre-steady-stat

106 M), the gene encoding the emerging New Delhi metallo-beta-lactamase, using label-free electrochemical

107 iotic resistance factor called the New Delhi metallo-beta-lactamase-1 (NDM-1) has been found to confe

108 mediated resistance, specifically New Delhi metallo-beta-lactamase-1 (NDM-1).

109 lla pneumoniae Carbapenemase-4 and New Delhi Metallo-beta-Lactamase-1 in the United States, recogniti

110 New Delhi metallo-beta-lactamase-1 was found in almost every conti

111 y drug-resistant E. coli harboring New Delhi metallo-beta-lactamase-1.

112 LIG, an ATP-dependent DNA ligase; and Exo, a metallo-beta-lactamase-family nuclease.

113 hat the ancestor was unlikely to have been a metallo-beta-lactamase.

114 15 coproducing an AmpC and 11 coproducing a metallo-beta-lactamase.

115 ecially with isolates coproducing an AmpC or metallo-beta-lactamase.

116 ESBL in 90.1% of isolates that coproduced a metallo-beta-lactamase.

117 SNM1B/Apollo is a member of metallo-beta-lactamase/betaCASP family of nucleases and

118 shared sequence homology with beta-lactamase/metallo-beta-lactamases (enzymes that provide resistance

119 preparation of a set of clinically relevant metallo-beta-lactamases (i.e., NDM-1 (New Delhi MBL), IM

120 -A, and SME type), 40 isolates that produced metallo-beta-lactamases (including NDM-1, GIM-1, SPM-1,

121 Metallo-beta-lactamases (MbetaLs) are the main mechanism

122 Metallo-beta-lactamases (mbetals) confer broad-spectrum

123 ria pose a major health threat by expressing metallo-beta-lactamases (MbetaLs), enzymes able to hydro

124 mase-producing Enterobacteriaceae (CPE) with metallo-beta-lactamases (MbetaLs).

125 (ESBL), KPC- and OXA-type carbapenemases and metallo-beta-lactamases (MBL).

126 Metallo-beta-lactamases (MBLs) are a growing threat to t

127 Although transmissible metallo-beta-lactamases (MBLs) are a serious threat to b

128 Metallo-beta-lactamases (MBLs) are particularly problema

129 Metallo-beta-lactamases (MBLs) degrade a broad spectrum

130 Metallo-beta-lactamases (MBLs) efficiently hydrolyze and

131 Metallo-beta-lactamases (MBLs) hydrolyze almost all beta

132 Development of metallo-beta-lactamases (MBLs) inhibitors has proven cha

133 tance to beta-lactam antibiotics mediated by metallo-beta-lactamases (MBLs) is a growing problem.

134 The acquisition of metallo-beta-lactamases (MBLs) such as NDM-1 is a princi

135 expressing serine beta-lactamases (SBLs) and metallo-beta-lactamases (MBLs), especially those with ca

136 tamases (SBLs) and some clinically important metallo-beta-lactamases (MBLs), including NDM-1 and VIM-

137 The worldwide dissemination of metallo-beta-lactamases (MBLs), mediating resistance to

138 lasses A, C and D) and the zinc-dependent or metallo-beta-lactamases (MBLs; class B).

139 PC-2, SFC-1, CMY-10, OXA-23, and OXA-48) and metallo-beta-lactamases (NDM-1, VIM-1, BcII, CphA, and L

140 -beta-lactamases (VIM; n = 27) and New Delhi metallo-beta-lactamases (NDM; n = 13) tested had 100% co

141 on eCIM testing, all Verona integrin-encoded metallo-beta-lactamases (VIM; n = 27) and New Delhi meta

142 g between serine- and metal-dependent (i.e., metallo-beta-lactamases [MBLs]) carbapenemases when used

143 reaction mechanism to be offered for the B2 metallo-beta-lactamases and demonstrate that the mono- a

144 ass of monocyclic beta-lactams are stable to metallo-beta-lactamases and have excellent P. aeruginosa

145 the determinants of substrate specificity in metallo-beta-lactamases and the design of potentially cl

146 bacteria that produce extended-spectrum- and metallo-beta-lactamases are being discovered at an alarm

147 Metallo-beta-lactamases are native zinc enzymes that cat

148 Metallo-beta-lactamases are responsible for conferring a

149 Metallo-beta-lactamases catalyze the hydrolysis of most

150 Metallo-beta-lactamases challenge antimicrobial therapie

151 Recently however, metallo-beta-lactamases have originated in Asia.

152 cific detection of carbapenemases, including metallo-beta-lactamases in active bacterial pathogens.

153 Reduced holomycin also strongly inhibits metallo-beta-lactamases in vitro, major contributors to

154 a kinetic mechanism similar to that used by metallo-beta-lactamases L1 and CcrA, in which a reactive

155 the binding of substrates and inhibitors to metallo-beta-lactamases may involve binding to the organ

156 Furthermore, in contrast to metallo-beta-lactamases or Klebsiella pneumoniae carbape

157 However, avibactam does not inactivate metallo-beta-lactamases such as New Delhi metallo-beta-l

158 nding site is very similar to those of other metallo-beta-lactamases that belong to the B1 subclass.

159 ative directed evolution of four orthologous metallo-beta-lactamases toward a new function and found

160 now report KPC serine carbapenemases and the metallo-beta-lactamases VIM, IMP, and NDM-1, even though

161 nhibitors effective against both serine- and metallo-beta-lactamases, and which could also have antim

162 we reconstructed a sample of 98 MRCAs of the metallo-beta-lactamases, each based on a different tree

163 A total of 88 New Delhi metallo-beta-lactamases-type carbapenem-resistant Escher

164 te metallo-beta-lactamases such as New Delhi metallo-beta-lactamases.

165 ibiotics are recognized by dizinc-containing metallo-beta-lactamases.

166 esign of novel inhibitors of NDM-1 and other metallo-beta-lactamases.

167 -1 is similar in structure to other class B1 metallo-beta-lactamases.

168 carbapenemases, and the VIM, IMP, and NDM-1 metallo-beta-lactamases.

169 ith rate constants slower than those of most metallo-beta-lactamases.

170 t infection with MDR P. aeruginosa that lack metallo-beta-lactamases.

171 the same mandate exists for the detection of metallo-beta-lactamases.

172 We also discuss the evolution of metallo-beta-lactamases; this illustrates how rapid anti

173 New Delhi metallo-beta-lactmase-1 (NDM-1) has recently emerged as

174 A novel metallo-bioadhesive to be used as tissue sealant in mini

175 Our work provides new evidence into the metallo-biology of PD and opens new lines of research as

176 oped into the planes of borophenes to create metallo-borophenes, opening vast opportunities to design

177 These metallo-borospherenes represent a new class of unusual g

178 ort the observation of a class of remarkable metallo-borospherenes, where metal atoms are integral pa

179 emases in Enterobacteriaceae, while OXA- and metallo- carbapenemases are of growing importance in Aci

180 bly detected isolates with KPC and most with metallo-carbapenemases.

181 The metallo carbenoid derived from the D/A diazo group is pr

182 ional and experimental design of cobaltocene metallo-cations that have distinct electronic and redox

183 f a large subunit that harbors a NiFe(CN)2CO metallo-center and a small subunit with three iron-sulfu

184 es (UV-vis and fluorescence spectra) of the (metallo)chlorin-like chromophores that possess slightly

185 on, the inorganic chemistry of the essential metallo-cofactor biosynthesis/maintenance, the transport

186 flavodoxin essential for assembly of the RNR metallo-cofactor) have been identified and characterized

187 beta contains the metallo-cofactor, essential for the initiation of the re

188 ed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)3.

189 Here we present outcomes for the metallo-complex Cu(II)(atsm) tested for therapeutic effi

190 Here we report the novel use of a metallo-complex, desferrioxamine-gallium (DFO-Ga) that t

191 area of research, such as the combination of metallo-compound radiosensitizers with radionuclides and

192 Pd3L2 metallo-cryptophane cages with cyclotriveratrylene-type

193 specific members of the protein phosphatase metallo-dependent (PPM/PP2C) family and is independent o

194 Both dihydroorotases are members of the metallo-dependent hydrolase superfamily, whose members h

195 en the individual porphyrin systems, and the metallo derivatives also displayed significant variation

196 ap resonators, and, more recently, metallic, metallo-dielectric and plasmonic resonators.

197 Compact metallo-dielectric hybrid clusters with subwavelength di

198 ve metamaterial properties of thin, periodic metallo-dielectric multilayers by exploiting a broadband

199 Further, we identified the metallo-endopeptidase CpaA, which has been shown previou

200 substrate binding pocket conserved in active metallo-endopeptidases has been adapted to control PG hy

201 rally and/or biochemically characterized are metallo-endopeptidases that cleave cross-links in the pe

202 tructures resemble lysozyme-like enzymes and metallo-endopeptidases, respectively.

203 onjugate reduction to form discrete enol or (metallo)enolate derivatives followed by introduction of

204 group; (2) [3+n]-cycloadditions (n = 1-5) by metallo-enolcarbenes formed by catalytic dinitrogen extr

205 +1]-cycloaddition of catalytically generated metallo-enolcarbenes was successfully extended to reacti

206 Most important among these are the class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the clas

207 of biomimetic complexes for the modeling of metallo-enzyme active sites is a fruitful strategy for o

208 lial ALS cases is caused by mutations in the metallo-enzyme copper-zinc superoxide dismutase (SOD1).

209 hich spin-state is key, including catalysis, metallo-enzyme modeling studies, and host-guest chemistr

210 IP5 2-K from Arabidopsis thaliana is a zinc metallo-enzyme, including two separated lobes (the N- an

211 onal and aberrant hole-transfer reactions in metallo-enzymes.

212 molecular dynamics simulations of the dizinc metallo form indicates that the dinuclear metal cluster

213 difference in DNA affinity for the different metallo forms of Fur.

214 monoxide, aldehydes, and olefins to produce metallo formyl, alpha-hydroxyalkyl, and alkyl complexes,

215 activity and regioselectivity of (endohedral metallo)fullerenes have in the past decade been shown to

216 e on interactions of diastereomerically pure metallo-helical 'flexicate' complexes, bimetallic triple

217 ates the potential of utilizing well-defined metallo-helical complexes for cancer chemotherapy.

218 e backbone of P into a right- or left-handed metallo-helicoid (H) with double rims.

219 esonance Raman (UVRR) spectroscopy to define metallo-Hst-5 interactions in aqueous solution.

220 ne) complex affords the first supramolecular metallo-hydrogelator that not only self assembles in wat

221 ive site of the formyltransferase (FhcD) and metallo-hydrolase (FhcA).

222 or the first time the identification of five metallo-intramembrane cleaving proteases in Anabaena var

223 metallo KDO8PS from Escherichia coli and the metallo KDO8PS from Aquifex aeolicus are the best charac

224 lectrocatalytic MOFs based on a redox-active metallo-linker, this work explores uncharted terrain for

225 baloximes, a widely studied HEC, that act as metallo-linkers between hexanuclear zirconium clusters.

226 rovided by beta-lactamases belonging to both metallo (MBL)- and serine (SBL)-beta-lactamase subfamili

227 s the catalyst, tandem 1,3-acyloxy migration/metallo-Nazarov cyclization/1,6-enyne addition/Cope rear

228 ng a more rapid tandem 1,3-acyloxy migration/metallo-Nazarov cyclization/[4 + 2]-cyclization pathway

229 ement and control the emergent properties of metallo-OPE materials.

230 of an orthogonal mid-pi/pi*-gap d orbital in metallo-OPEs.

231 tions and oxygenations in the absence of any metallo- or organic cofactor.

232 Photoredox catalysts are metallo- or organo-compounds capable of absorbing visibl

233 This opens up a new field of metallo-organic antifreeze protein mimetics and provides

234 eral of my group's research contributions in metallo-organic chemistry over the past 40 years.

235 plexes were employed to construct brominated metallo-organic intermediates, followed by a Suzuki coup

236 were prepared based on the careful design of metallo-organic ligands (MOLs).

237 py-Ru(2+) -tpy was employed to construct two metallo-organic ligands for the assembly of G2 and G3 Si

238 The metallo-organic ligands L(A) and L(B) with multiple free

239 nder equilibrium control, numerous nanoscale metallo-organic particles with potentially useful proper

240 With clusters deposited via metallo-organic Pt or PtRu(5) complexes, previous experi

241 These enzymes constitute an unusual pair of metallo-oxygenases that remain fully active after a meta

242 esponse.See related commentary by Cordes and Metallo, p.

243 This method was applied to several metallo Pcs.

244 were not hydrolyzed by serine, aspartic, or metallo peptidases.

245 igestion (cysteine-, aspartic-, serine-, and metallo-peptidases), cell, protein and lipid binding inc

246 The protein consists of a core binuclear metallo-phosphoesterase fold (exemplified by bacteriopha

247 Metallo-photoredox catalysis has redefined the available

248 olecular beacon (MB) probe consisting of two metallo-phthalocyanine (Pc) fluorophores that use near-I

249 ther environments and by the eminent role of metallo-phthalocyanines in synthetic materials, the cont

250 s, which are further integrated to construct metallo-polyelectrolytes as anion-exchange membranes in

251 feasible strategy to construct a new type of metallo-polymer with helicoidal structure through the co

252 Zr6-polyoxo-cluster and uniformly embedded (metallo)porphyrin centers endow CPM-99 with highly desir

253 series of zirconium polyphenolate-decorated-(metallo)porphyrin metal-organic frameworks (MOFs), ZrPP-

254 As highlighted by the functionality of metallo-porphyrins in biological or other environments a

255 terobimetallic organic catalysts compared to metallo-porphyrins.

256 ficiently inhibit anthrax lethal factor (LF) metallo-protease.

257 e presence of aspartic, cysteine, serine and metallo proteases.

258 the soluble IL-6R by ADAM (a disintegrin and metallo) proteases enables IL-6 trans-signaling, in whic

259 ariety of serine-, cysteine-, carboxyl-, and metallo-proteases, including trypsin, chymotrypsin, peps

260 stic classes-serine, cysteine, aspartyl, and metallo-proteases-and develop a discriminatory scoring f

261 Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause

262 n health and disease: decorin and the Matrix Metallo-Proteinase (MMP) collagenase.

263 serine proteinase, cysteine proteinase, and metallo-proteinase families.

264 decreased expression of PD-L1 and of matrix metallo-proteinases (MMPs) and CD-10 in those cells.

265 during morphogenesis, the function of matrix metallo-proteinases (MMPs) and their inhibitors, the tis

266 e treatment increased the activity of matrix metallo-proteinases that initiate degradation of the BBB

267 complex (bio)molecular structures including metallo-proteins like myoglobin.

268 In metallo-proteins, characterization of the folding pathwa

269 ytic properties of single-atom catalysts and metallo-proteins, we exploit the potential of metal-orga

270 Of the several metallo-QDO enzymes examined for nitroxygenase activity

271 The metallo-radical catalyzed indene synthesis in this paper

272 The imine acts as a simple modular metallo-reactive fluorophore.

273 The combination of light- and metallo-responsiveness in the same polymer provides the

274 milies, C56 and C64 (cysteine), M20 and M23 (metallo), S24 and S28 (serine) as revealed by a lack of

275 ixed (Section 6), desymmetrized (Section 7), metallo (Section 8), and N-heterocyclic linkers (Section

276 The classical strategy for modeling metallo-sites relies on the synthesis of metal complexes

277 New Delhi metallo-ss-lactamase (NDM) has emerged worldwide in clin

278 in catalysis, this implies that the various metallo-substituted enzymes are capable of some level of

279 report the first X-ray crystal structures of metallo-substituted HDAC8, Co(2+)-HDAC8, D101L Co(2+)-HD

280 constructed on adamantane, three discrete 3D metallo-supramolecular architectures were assembled, i.e

281 s investigated for the first time exploiting metallo-supramolecular chemistry.

282 This metallo-supramolecular functionality allowed direct visu

283 ave achieved formation of stimuli-responsive metallo-supramolecular gels.

284 The self-assembly of irregular metallo-supramolecular hexagons and parallelograms has b

285 me, this new topology has been combined with metallo-supramolecular interactions to construct novel c

286 A particular fascinating class of metallo-supramolecular molecules are hollow coordination

287 Facile construction of metallo-supramolecular poly(3-hexylthiophene) (P3HT)-blo

288 les with Zn(2+) ion to form a highly soluble metallo-supramolecular polymer 1 with M(n) approximately

289 They display the design simplicity of metallo-supramolecular polymers with transfer of the str

290 the N-alkyl residues on the periphery of the metallo-supramolecular scaffolds over 4 days in DMSO at

291 The resulting metallo-supramolecular structure explored by scanning tu

292 The synthesis of metallo-supramolecular systems with well-defined shapes

293 ands was exploited to construct heteroleptic metallo-supramolecules and to investigate the self-assem

294 plexity for calix[4]resorcinarene-containing metallo-supramolecules.

295 stituting the metal-coordinating cysteine of metallo synthases with the corresponding asparagine of n

296 several fields, provide an elegant route to metallo-tetrapyrrole systems often elusive to convention

297 The first generation (G1) metallo-triangles were directly obtained by reacting a b

298 onal supramolecular architectures, so-called metallo-triangles, were assembled from terpyridine (tpy)

299 h Zn(II) or Cd(II) to obtain high-generation metallo-triangular architectures in nearly quantitative

300 hydrophobic effect, which we define as the "metallo-zipper."