ライフサイエンスコーパス: metalloid

1 ArsD at 1.4 A and a model for its binding of metalloid.

2 , as opposed to release and rebinding of the metalloid.

3 rolyze trinucleotide, even in the absence of metalloid.

4 reduced amphibian skin permeability to this metalloid.

5 development of strategies against this toxic metalloid.

6 nt and increased tolerance to this hazardous metalloid.

7 Arsenic (As) is a toxic metalloid.

8 ments, making it a major sink for this toxic metalloid.

9 n of the rates of binding and affinities for metalloids.

10 ing responses to toxic transition metals and metalloids.

11 bilization potential of hazardous metals and metalloids.

12 sO)(n), (SbO)(n), or a co-polymer of the two metalloids.

13 been shown to facilitate uptake of trivalent metalloids.

14 eric ArsD, with only one site releasing free metalloids.

15 are a potential source of exposure to metals/metalloids.

16 and the fate of nutrients, toxic metals and metalloids.

17 lity to sequester a wide range of metals and metalloids.

18 quality limits, mainly with heavy metals and metalloids.

19 voltaic cells crucially depend on metals and metalloids.

20 inated sediment had a more important role in metalloid accumulation than aqueous exposure alone.

21 imental results demonstrated that Zn(delta+) metalloid active sites could facilitate the activation o

22 nce mechanisms became hypersensitive to both metalloids after expression of LmAQP1.

23 drive As methylation in the presence of the metalloid and (ii) there is an inverse relationship betw

24 Arsenic trioxide is a toxic metalloid and carcinogen that is also used as an antican

25 of glycerol, this is the first report where metalloid and glycerol transport can be dissected by a s

26 s-172 controls the affinity of this site for metalloid and hence the efficiency of metalloactivation

27 of ATP hydrolysis is slow in the absence of metalloid and is accelerated by metalloid binding.

28 ATP hydrolysis is slow in the absence of metalloid and is accelerated by metalloid binding.

29 cellular sensitivity to arsenicals and other metalloids and can modulate intracellular glutathione me

30 The presence of metalloids and heavy metals in the environment is of cri

31 k because of the low concentration of metals/metalloids and the correspondingly high molecular chemic

32 orrelation between the content of metals and metalloids and the storage time of opened cans.

33 ter shell electronic structure of metals and metalloids and the viscoelasticity and fragility thereof

34 Because arsenic and antimony are related metalloids, and arsenical resistant Leishmania strains a

35 nvestigation of metal-based ENMs compared to metalloid- and carbon-based ENMs but also nanoenabled pr

36 amples of microbial metabolism of metals and metalloids; and expanded the types of information it inc

37 anic anions (MRP1 substrates) as well as the metalloid antimonite (K(i) 2.8 microM).

38 c results in cross-resistance to the related metalloid antimony, present in the pentavalent state as

39 Metals and metalloids are used as weapons for predatory feeding by

40 alpha-Stereogenic allyl metalloids are versatile synthetic intermediates which c

41 e) minerals determines the fate of the toxic metalloid arsenic (As) in many subsurface environments.

42 ochemical cycling, including the toxic trace metalloid arsenic (As).

43 The ubiquitous toxic metalloid arsenic elicits pleiotropic adverse and adapti

44 The toxic metalloid arsenic has been environmentally ubiquitous si

45 Exposure to the toxic metalloid arsenic is associated with diabetes and cancer

46 obic respiration of ferric iron or the toxic metalloid arsenic is well known to affect water quality

47 The toxic metalloid arsenic is widely distributed in food, water,

48 e majority of the transport of the trivalent metalloid arsenic trioxide.

49 common iron oxides and a sink for the toxic metalloid arsenic.

50 ce to trivalent and pentavalent salts of the metalloid arsenic.

51 ce to trivalent and pentavalent salts of the metalloids arsenic and antimony in cells of Escherichia

52 ce to trivalent and pentavalent salts of the metalloids arsenic and antimony in cells of Escherichia

53 The toxicity of the metalloids arsenic and antimony is related to uptake, wh

54 r cells to survive exposure to the trivalent metalloids arsenic and antimony.

55 common heavy metal contaminant lead and the metalloids arsenic and selenium in mine tailings and con

56 on H2S production and the leaching of metals/metalloids (arsenic, copper, chromium, and boron) from t

57 Treatment of yeast with the toxic trivalent metalloid arsenite (As(III)) also activates Hog1 as part

58 The poisonous metalloid arsenite induces widespread misfolding and agg

59 73 confers resistance to the toxic trivalent metalloids arsenite [As(III)] and antimonite [Sb(III)].

60 p has been shown to facilitate uptake of the metalloids arsenite and antimonite, and the Escherichia

61 s responsible for the transport of trivalent metalloids, arsenite and antimonite.

62 Reductive release of the potentially toxic metalloid As from Fe(III) (oxyhydr)oxides has been ident

63 avy metals including Cd(2+), Hg(2+), and the metalloid As(3+) into the vacuole to safely sequester th

64 ), Cd(II), Cu(II), Ni(II) and Zn(II) and the metalloid As(V).

65 higher levels of the heavy metal Cd and the metalloid As, it does not increase the accumulation pote

66 rferences from several transition metals and metalloids as well as inorganic acids and their anions w

67 e ArsAB pump that catalyzes extrusion of the metalloids As(III) and Sb(III), conferring metalloid res

68 s the ArsAB extrusion pump for the trivalent metalloids As(III) and Sb(III).

69 ter DNA by binding of the compounds with the metalloids As(III) or Sb(III).

70 Pb, Cr, Mn, Co, Cu, Zn, As, Ag, and THg) and metalloid (As) concentrations in the muscle tissue of co

71 s trace metals (Cd, Co, Cu, Mn, Ni, and Zn), metalloids (As) and nonmetals (Se) in their shoots.

72 s a metallochaperone that delivers trivalent metalloids [As(III) or Sb(III)] to the ArsA ATPase, the

73 Although the metalloids, As(III) and Sb(III), are believed to be tran

74 The ArsD metallochaperone delivers trivalent metalloids, As(III) or Sb(III), to the ArsA ATPase, the

75 ave assessed the major uses of 56 metals and metalloids, assigning each use to one of three categorie

76 to better understand the form of metals and metalloids associated with the glass beads.

77 stal structure of ArsA shows two other bound metalloid atoms, one liganded to Cys-172 and His-453, an

78 The relation between metalloid binding by ArsA and transport through ArsB is

79 The metalloid binding domain is connected to the two nucleot

80 ng a nucleotide binding domain, and a single metalloid binding or activation domain is located at the

81 422A)B in less than 1 week, showing that the metalloid binding site confers an evolutionary advantage

82 st that there is only a single high-affinity metalloid binding site in ArsA, and second that Cys-172

83 Four are close to metalloid binding site residues Cys-12, Cys-13 and Cys-1

84 face involves one surface of helix 1 and the metalloid binding site.

85 -422 have been shown to form a high-affinity metalloid binding site.

86 In this study, direct metalloid binding to ArsA was examined.

87 The kinetics of metalloid binding were determined by stopped flow spectr

88 tagenesis of residues His-148 and Ser-420 on metalloid binding.

89 e absence of metalloid and is accelerated by metalloid binding.

90 e absence of metalloid and is accelerated by metalloid binding.

91 ves are two nucleotide-binding domains and a metalloid-binding domain.

92 onnects the nucleotide-binding domain to the metalloid-binding domain.

93 of As(III) to the conserved cysteines at the metalloid-binding site of the closed state.

94 I) displacement by As(III) revealed that the metalloid-binding sites behave differentially, with the

95 nic (As) is considered the most common toxic metalloid, but its molecular mode of action is not well

96 ation of metalloid, high affinity binding of metalloid by ArsA is not obligatory for transport or res

97 ntrol the distribution of these toxic metals/metalloids by affecting their mobility in soils.

98 (V) and Sb(V) decreased the sorption of both metalloids by almost 50%.

99 ntrolling factor elucidation of toxic metals/metalloids by introducing an index, enrichment factor (E

100 olving the sequential binding and release of metalloids by the four binding sites of dimeric ArsD, wi

101 hoate >> tau-fluvalinate), then trace metals/metalloids (cadmium, arsenic), followed by the fungicide

102 In this study, eight toxic metals/metalloids (Cd, Cr, Pb, Ni, Cu, Zn, As, and Hg) in Everg

103 taphyrin has been obtained, proving that the metalloid center acts as the topology selector stabilizi

104 the synthesis of the all-phosphine protected metalloid cluster Au(20) ((t) Bu(3) P)(8) , solely built

105 In the mine impacted environment, metals and metalloids commonly coexist in a variety of species.

106 in combination with one or two metal and/or metalloid components as the catalyst.

107 y an effective tool for evaluating metal and metalloid concentrations but can suffer from poor replic

108 sIII oxidation and AsIII/SbIII resistance at metalloid concentrations inhibitory to the Deltaacr3-1 m

109 course experiments following the changes in metalloid-containing anion concentrations.

110 The metalloid-containing anions examined were selenocyanate,

111 olecular-level speciation of heavy metal and metalloid contaminants in various environmental settings

112 d via different metal centers or neighboring metalloid coordination.

113 suggests that in addition to Hg other metals/metalloids could also potentially be an environmental pr

114 vant to the geomicrobiology of environmental metalloid cycling as well as informing applied approache

115 13 pair was required for the majority of the metalloid-dependent quenching of Trp-97 fluorescence.

116 is of key importance in most conversions of metalloid derivatives catalyzed by TM complexes.

117 r species, the formal oxidation state of the metalloid diminishes from III, to II, to I, and finally

118 ponent compounds of metals and chalcogens or metalloids, doped fullerenes and organic charge-transfer

119 This is the first report of the uptake of a metalloid drug by an aquaglyceroporin in Leishmania, sug

120 s As during crystallization and retains this metalloid during the transformation from struvite, can a

121 te and metabolism of Se (and other metal and metalloids) during anuran development and the implicatio

122 s, those involving the transition metal (TM)-metalloid (E) bond, is of key importance in most convers

123 in the catalytic transformations of selected metalloids (E = B, Si, Ge, Sn, As, Sb, or Te).

124 measurement site are enriched in metals and metalloids (e.g., arsenic, lead, and cadmium) and water-

125 were found to have elevated levels of metals/metalloids (e.g., mercury, arsenic, and lead) with separ

126 sorption spectroscopy conducted at metal and metalloid edges has suggested that the magnetite {111} f

127 roviding homeostasis of essential metals and metalloid elements.

128 e rapidly increased the influx of metals and metalloids entering the marine environment, which can bi

129 ance of DOM sulfurization to trace metal and metalloid (especially mercury) fate in the environment.

130 Arsenic, a toxic metalloid, exists in the natural environment and its org

131 rkable tolerance of toad tadpoles to extreme metalloid exposure and implicate physiological processes

132 e-cigarette device systems to evaluate metal/metalloid exposure levels for e-cigarette users and the

133 metamorphosis, were associated with elevated metalloid exposure.

134 control microbiomes are suppressed by metal/metalloid field exposure, including eradication of the h

135 D to ArsA, consistent with channeling of the metalloid from one protein to the other, as opposed to r

136 nce for and accumulation of heavy metals and metalloids from soil by expressing an Arabidopsis thalia

137 Metalloid gold clusters have unique properties with resp

138 Three multi-shell metalloid gold clusters of the composition Au(32) (R(3)

139 alization of C-H bonds with vinylmetalloids, metalloid halides, and sulfonates; and dehydrocoupling o

140 Recently, metals and metalloids have been observed at elevated concentrations

141 to reduce the intracellular concentration of metalloid, high affinity binding of metalloid by ArsA is

142 drocarbons compounds (PHC), heavy metals and metalloids (HM) in soil.

143 Arsenite is a well known metalloid human carcinogen, and epidemiological evidence

144 ysis of the following processes: addition of metalloid-hydrogen and metalloid-metalloid bonds to unsa

145 deposits and record the accumulation of this metalloid in the food chain.

146 ors have been identified to stably bind this metalloid in vivo.

147 haracterize the criticality of 62 metals and metalloids in a 3D "criticality space" consisting of sup

148 of conceivably detrimental heavy metals and metalloids in diverse environmental constituents and the

149 of studies, however, have found toxic metals/metalloids in e-cigarette emissions.

150 R), and Web of Science for studies on metals/metalloids in e-liquid, e-cigarette aerosols, and biosam

151 We identified 24 studies on metals/metalloids in e-liquid, e-cigarette aerosols, and human

152 ting ATPase that confers resistance to those metalloids in Escherichia coli.

153 t roles in detoxification of heavy metal and metalloids in plants and other living organisms.

154 e effects of anthropogenic sources on metals/metalloids in soils.

155 ribution and potential risks of toxic metals/metalloids in the Everglades.

156 Although the heavy metals/metalloids in the groundwater were at low concentrations

157 Arsenic (As) is one of four metals/metalloids in tobacco being considered for regulation.

158 oduction is induced by a range of metals and metalloids including arsenate.

159 equestering a wide range of heavy metals and metalloids, including arsenic.

160 z1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitin

161 unaffected by arsenite, suggesting that this metalloid influences aggregate structure, making them le

162 concern to organisms that bioaccumulate the metalloid into their tissues.

163 g methods to prepare alpha-stereogenic allyl metalloids involve multi-step sequences that curtail the

164 of a range of environmentally relevant metal/metalloid ions as well as natural and artificial ligands

165 of genes for resistance to heavy metals and metalloids is usually transcriptionally regulated by the

166 ikely contribute to the variability in metal/metalloid levels across studies, making comparison acros

167 Most metal/metalloid levels found in biosamples of e-cigarette user

168 ed protocols for the quantification of metal/metalloid levels from e-cigarette samples are needed.

169 n wick, and tank), 12 studies reported metal/metalloid levels in e-cigarette aerosols (from cig-a-lik

170 We summarized the evidence on metal/metalloid levels in e-cigarette liquid (e-liquid), aeros

171 For metal/metalloid levels in e-liquid and aerosol samples, we col

172 Metal/metalloid levels in e-liquid from cartridges or tank/ope

173 Twelve studies reported metal/metalloid levels in e-liquids (bottles, cartridges, open

174 Metal/metalloid levels in e-liquids and aerosols were converte

175 tank devices), and 4 studies reported metal/metalloid levels in human biosamples (urine, saliva, ser

176 Metal/metalloid levels showed substantial heterogeneity depend

177 Metal/metalloid levels, including aluminum, antimony, arsenic,

178 olatile organic chemical metabolites, metals/metalloids, levoglucosan, and cotinine.

179 r, it was resistant to many heavy metals and metalloids like cadmium, chromium, copper, mercury, arse

180 Soil contamination by metals and metalloids (metal[loid]s) is a global issue with signifi

181 rocesses: addition of metalloid-hydrogen and metalloid-metalloid bonds to unsaturated compounds; acti

182 an Arkel-Ketelaar triangle, indicating their metalloid nature.

183 rform anodic electrochemical oxidation of Ni-metalloids (NiP(x), NiS(x), and NiSe(x)) to in-situ cons

184 yotes are known to grow on and respire toxic metalloids of arsenic (i.e., arsenate and arsenite).

185 n about the pollution status of toxic metals/metalloids of potential concern, except for Hg.

186 d to ArsD and then to ArsAB, which pumps the metalloid out of the cell.

187 trolling the transport and fate of metal and metalloid oxyanions in natural and applied systems.

188 nation, (2) a thiophilic, trigonal pyramidal metalloid (Pb(II)) that binds to these sulfurs and (3) a

189 nable detailed structure-function studies of metalloid porins, including the basis of their substrate

190 ised NIP subfamily of aquaporins, also named metalloid porins.

191 (Pb), whereas greater than 97% of metals and metalloids present were associated with the glass matrix

192 Water pollution by metals and metalloids promotes toxic effects to aquatic biota espec

193 te that ArsB is an antiporter that catalyzes metalloid-proton exchange.

194 A/C422A)B genes had an intermediate level of metalloid resistance and accumulation between those expr

195 e metalloids As(III) and Sb(III), conferring metalloid resistance.

196 us species harvested from the environment is metalloid resistant and, when grown anaerobically in com

197 in a 3.8-kb chromosomal DNA fragment from a metalloid-resistant thermophile, Geobacillus stearotherm

198 s-119-Cys-120 had no effect on repression or metalloid responsiveness in vivo or in vitro.

199 f the steady-state fluorescence of ArsD with metalloids revealed positive cooperativity, with a Hill

200 nzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a

201 F, facilitates the uptake and sensitivity to metalloid salts.

202 risk due to plant uptake of the contaminant metalloids (Sb) and arsenic (As).

203 ion is a key element in the mechanism of the metalloid-selective recognition of this protein.

204 For example, bees are exposed to the metalloid selenate when foraging on pollen and nectar fr

205 The metalloid selenium was present in the CC (1.8, range < 1

206 uptake of As(III) or Sb(III) correlated with metalloid sensitivity of the wild type and drug-resistan

207 Herein, we reveal the Zn(delta+) metalloid sites as the real active sites of stable nonst

208 The contribution of those putative metalloid sites was examined.

209 inhardtii cells and of the effect this toxic metalloid species has on their lipid profile.

210 n exhibited varying levels of both basal and metalloid-stimulated activity, indicating that neither A

211 y similar to that of the wild type but lacks metalloid-stimulated activity.

212 Binding of metalloids stimulates ATPase activity.

213 P]-triphosphate at 4 degrees C indicate that metalloid stimulation correlates with a >10-fold increas

214 The results indicate that, whereas metalloid stimulation of ArsA activity enhances the abil

215 formation of synthetically highly versatile metalloid-substituted alkenes, which are key building bl

216 formation of synthetically highly versatile metalloid-substituted alkenes, which are key building bl

217 e effects of extreme concentrations of toxic metalloids, such as arsenic (As) and antimony (Sb), on l

218 Trivalent metalloids, such as arsenic, have been proposed to cause

219 Although analysis of metals and metalloids, such as arsenic, is widely spread in many di

220 ities that result in pollution by metals and metalloids, such as Brazil.

221 The metalloid tellurite is highly toxic to microorganisms.

222 Arsenic is a metalloid that generates various biological effects on c

223 Antimony (Sb) is a metalloid that has been exploited by humans since the be

224 Arsenic (As) is a well-known metalloid that restricts the growth and productivity of

225 entially form separate binding sites for the metalloids that trigger dissociation of ArsD from the op

226 esistance is proposed to be formation of the metalloid-thiol pump substrates, so that increased synth

227 ne adducts with concomitant reduction of the metalloid to active Sb(III) species.

228 ArsD transfers trivalent metalloids to ArsA, the catalytic subunit of an As(III)/

229 h as zinc (Zn) and copper (Cu), and possibly metalloids, to kill their bacterial prey after phagocyto

230 ally, various mechanisms for heavy metal and metalloid tolerance and virulence point to a lifestyle w

231 on of a plasmid containing AQP9 reverses the metalloid tolerance of the deletion strain.

232 shown that the microbiome of animals reduces metalloid toxicity, we assayed the ability of the bee mi

233 ide further understanding of fungal roles in metalloid transformations and are relevant to the geomic

234 to alanine, aspartate and glutamine affected metalloid transport in the order, wild-type > E152Q > E1

235 Besides metalloid transport, LmAQP1 is also permeable to water,

236 (MDR)-1 is the key factor in the failure of metalloid treatment in kala-azar patients infected with

237 tion to jarosite at pH 3 (in dual and single metalloid treatments).

238 Relative to single metalloid treatments, the dual presence of both As(V) an

239 er extent than As(V) in both single and dual metalloid treatments.

240 mperative for us to understand mechanisms of metalloid uptake and detoxification.

241 may help better understand the mechanisms of metalloid uptake, tolerance and detoxification in plants

242 ctive preparation of alpha-stereogenic allyl metalloids utilizing dual CuH- and Pd-catalysis.

243 Accumulation of metalloid was assayed in intact cells, where reduced upt

244 Metalloids were initially concentrated in the gut; howev

245 their anions, several transition metals, and metalloids were investigated.

246 Of 11 chemical groups, metals/metalloids were most frequently evaluated (49%), followe

247 Arsenic is a metalloid whose name conjures up images of murder.

248 Arsenic (As) is a redox-active metalloid whose toxicity and mobility in soil depend on

249 c is a ubiquitous, naturally occurring toxic metalloid widely distributed in soil and groundwater.

250 s to As(III) and Sb(III) by coordinating the metalloids with three cysteines, located in a short sequ

251 e predominant emission source for metals and metalloids, with Cd released to such extents that PEC (1

252 igh-affinity binding site that can sequester metalloid within the cell, followed by a nucleotide-driv

253 we spatially quantify transition metals and metalloids within organic material from 3.33 billion-yea