ライフサイエンスコーパス: metallopeptidase

1 consistent with the suggestion that it is a metallopeptidase.

2 ursor is synthesized as a latent form of the metallopeptidase.

3 Dase, or NAAG peptidase) is a catalytic zinc metallopeptidase.

4 locked by o-phenanthroline and thus required metallopeptidases.

5 sence of an HXXEH motif found in a subset of metallopeptidases.

6 ctive site helices, are conserved with other metallopeptidases.

7 process involving o-phenanthroline-sensitive metallopeptidases.

8 P. falciparum and the unusual M16 family of metallopeptidases.

9 of many zinc-dependent metalloproteases and metallopeptidases.

10 a member of the M3 or thimet family of zinc metallopeptidases.

11 ctivity against structurally homologous zinc metallopeptidases.

12 rotein and a member of the M1 family of zinc metallopeptidases.

13 proposed assay was demonstrated using matrix metallopeptidase 1 (MMP-1), a protease of the same famil

14 the BBB-deficit group show increased matrix metallopeptidase 1 (MMP1) activity, which correlated wit

15 Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease in

16 ating macrophage-derived tissue inhibitor of metallopeptidase 1 (TIMP-1) is the key factor in maintai

17 nuclear factor-kappaB activation and matrix metallopeptidase 1 expression.

18 r factor-kappaB activation leading to matrix metallopeptidase 1 up-regulation.

19 ceptor 15, Toll-like receptor 21, and matrix metallopeptidase 1.

20 Matrix metallopeptidase-1 correlated with subretinal fluid volu

21 LR2) expression, oxidative stress, or matrix metallopeptidase 12 (MMP-12) expression.

22 ealed fructose elevated expression of matrix metallopeptidase 12 (Mmp12), interleukin 1 receptor anta

23 -associated phosphoprotein 1 (SKAP1), matrix metallopeptidase 12 (MMP12)/MMP13, catenin alpha3 (CTNNA

24 marked increase in the expression of matrix metallopeptidase 13 (MMP13) and tartrate-resistant acid

25 Matrix metallopeptidase 13 (MMP13) was identified as a direct t

26 ocytes of the OA patients overexpress matrix metallopeptidase 13 (MMP13), a.k.a. collagenase 3, which

27 vating transcription factor 3 (ATF3), matrix metallopeptidase 13 (MMP13), interleukin 1a (IL1a), BTG

28 assessed fibrosis-related parameters, matrix metallopeptidase 13 (MMP13, or collagen 3, which catalyz

29 MMP13 (matrix metallopeptidase 13) plays a key role in bone metabolism

30 connective tissue growth factor, and matrix metallopeptidase 13, etc.) and a key regulator of osteoc

31 Matrix metallopeptidase-13 (MMP-13) is a highly active and an a

32 However, matrix metallopeptidase 14 was identified as the most distincti

33 EGFR) and ADAM17 (a membrane disintegrin and metallopeptidase 17) in lung epithelial cells.

34 ein 2alpha (AP-2alpha) and consequent matrix metallopeptidase 2 (MMP2) gene expression.

35 -catenin and production of its target matrix metallopeptidase 2 (MMP2), a secreted enzyme involved in

36 ECM degradation through inhibition of matrix metallopeptidase 2 activity.

37 ses, mRNA levels of the gene encoding matrix metallopeptidase 2 are lower in mutant-infected tissue.

38 reased the expression and activity of matrix metallopeptidase 2 in aortas without affecting metabolic

39 3-HAA upregulated matrix metallopeptidase 2 via transcription factor nuclear fact

40 1; transforming growth factor-beta1; matrix metallopeptidase 2, 7, and 9; inhibitor of metalloprotei

41 e knockdown in mice restrained 3-HAA, matrix metallopeptidase 2, and resultant AAA formation by angio

42 osis factor alpha, interleukin-1beta, matrix metallopeptidase 2, heparan sulfate d-glucosaminyl 3-O-s

43 sion concurrent with MCP-1, IL-6, and matrix metallopeptidase 2.

44 sion concurrent with MCP-1, IL-6, and matrix metallopeptidase 2.

45 vealed that ANG expression stimulated matrix metallopeptidase-2 (MMP2) expression through the phospho

46 sis factor receptor-I, IL-1alpha, and matrix metallopeptidase-2, were elevated in the acute phase of

47 ptidase of unknown function belonging to the metallopeptidase 20 family.

48 ecessive mutations in MMP21 (encoding matrix metallopeptidase 21) in nine index cases with heterotaxy

49 , ovochymase 2 (OVCH2) and A disintegrin and metallopeptidase 28 (ADAM28), were expressed upon IS mat

50 gration-associated genes, such as the matrix metallopeptidase 3 (MMP3).

51 IL-24 induced the expression of matrix metallopeptidase 7 (MMP7) in SCC cells in culture.

52 modeling, associated with high expression of metallopeptidase-7, -9, and -12, diverged from anabolic

53 ed mitogen-activated protein kinase 7/matrix metallopeptidase 9 (MAPK7/MMP9) signalling as a driver f

54 pressed on Myeloid cells (TREM-1) and Matrix MetalloPeptidase 9 (MMP-9) are detected via direct assay

55 ssue revealed decreased expression of matrix metallopeptidase 9 (MMP-9) in mice exhibiting positive r

56 Levels of IL-8, matrix metallopeptidase 9 (MMP-9), and biomarkers of glucocorti

57 , monocyte chemoattractant protein-1, matrix metallopeptidase 9 (MMP-9), and fibroblast growth factor

58 acidic protein (GFAP) and a protease, matrix metallopeptidase 9 (MMP-9).

59 necrosis factor a (TNF-alpha)-induced matrix metallopeptidase 9 (MMP9) activity mediates formation of

60 rs and determined that DP103 elevates matrix metallopeptidase 9 (MMP9) levels, which are associated w

61 In addition, beta-catenin and matrix metallopeptidase 9 (MMP9) protein levels and reactive ox

62 rgets such as osteocalcin (Bglap) and matrix metallopeptidase 9 (Mmp9).

63 olony-stimulating factor (GM-CSF) and matrix metallopeptidase 9 (MMP9).

64 ibitor of Metalloproteinase 1 (TIMP1)/Matrix metallopeptidase 9 (MMP9)/Cluster of differentiation 44

65 rowth factor (VEGF), BCL2, BCLXL, and matrix metallopeptidase 9 [MMP9]) were increased in pediatric p

66 Osteoclast markers (matrix metallopeptidase 9 and cathepsin K) were up-regulated at

67 We found that cathepsin G and matrix metallopeptidase 9 directly inhibit parasite invasion in

68 Of the 3 top DEGs, matrix metallopeptidase 9 emerged particularly because Mendelia

69 genes, but increased cathepsin G and matrix metallopeptidase 9 expression.

70 trophoblast phenotype, including the matrix metallopeptidase 9 gene (Mmp9).

71 scular senescence, pericyte loss, and matrix metallopeptidase 9 secretion.

72 Finally, MMP9 (matrix metallopeptidase 9) was increased during the second and

73 etin 1), ANG2 (angiopoietin 2), MMP9 (matrix metallopeptidase 9), TSP1 (thrombospondin 1), etc.

74 of novel therapeutic targets, such as matrix metallopeptidase 9, against plaque rupture.

75 nd increased endothelial secretion of matrix metallopeptidase 9, which further contributed to RGC los

76 e generation of interleukin-1beta and matrix metallopeptidase 9.

77 gulate aSAT remodelling (i.e. reduced matrix metallopeptidase 9; P = 0.02; increased angiopoietin-2;

78 coordinate with constitutively active matrix metallopeptidase-9 (MMP-9), a protease that cleaves oste

79 at the known hematopoietic modulators matrix metallopeptidase-9 (MMP9) and kit ligand (KITL) were dec

80 higher expression of CD49d (P = .02), matrix metallopeptidase-9 (P = .004), CD38 (P = .009), CD80 (P

81 ) and reduced inflammatory biomarkers matrix metallopeptidase-9 and myeloperoxidase in plasma and spu

82 ature matrix as well as expression of matrix metallopeptidase-9 MMP-9.

83 totrophoblast cytoskeletal integrity, matrix metallopeptidase-9 secretion, invasion, and differentiat

84 elevated inflammatory cytokines, and matrix metallopeptidase-9 secretion.

85 del incorporating 3 serum biomarkers (matrix metallopeptidase-9, neuron-specific enolase, and vascula

86 lar endothelin growth factor, IL-17a, matrix metallopeptidase-9, or C-reactive protein.

87 se-3 cleavage, expressions of Bax and matrix metallopeptidase-9.

88 ubstitutions in many, but not all, conserved metallopeptidase active sites recapitulated the hydrogen

89 two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only h

90 quence motifs indicative of increased matrix metallopeptidase activity in urine from cancer patients.

91 erestingly, examination of the ATP-dependent metallopeptidase activity responsible for degradation of

92 A novel metallopeptidase activity, falcilysin, was purified from

93 ) and another co-expressing Pvalb with three metallopeptidases Adamts8, Adamts15 and Mme (PV-MP).

94 ledge, this is the first model of a Zn(2)(+) metallopeptidase and its substrate.

95 ftsH (PG0047) encoding an ATP-dependent zinc metallopeptidase and ptpA (PG1641) encoding a putative t

96 tified six new PG proteins, including an M48 metallopeptidase and two Absence of bc1 complex (ABC1) a

97 of direct antimicrobial activity by a matrix metallopeptidase, and describes a new antimicrobial pept

98 Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2)

99 We have investigated the role of a metallopeptidase (At1g09300) from Arabidopsis (Arabidops

100 These aminopeptidases are cocatalytic zinc metallopeptidases belonging to the peptidase family M28.

101 f A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and

102 ess transcription until it is cleaved by the metallopeptidase CapP.

103 of the seven strains use three cell surface metallopeptidases (CD13, CD26, and ACE2) as receptors, w

104 A prominent lymphocytic matrix metallopeptidase cell migration pathway, is central to a

105 ins of gelsolin (actin cytoskeleton), matrix metallopeptidases (collagen degradation), platelet funct

106 mes, and offer a catalytic mechanism for M23 metallopeptidases consistent with available structural a

107 itor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two

108 reover, inhibition of the overexpressed ADAM metallopeptidase domain 10 (ADAM10) in the resistant cel

109 spanin 33, and the alpha-toxin receptor ADAM metallopeptidase domain 10 (ADAM10) promotes junctional

110 metalloproteinase 2), MMP9, and ADAM10 (ADAM metallopeptidase domain 10) levels.

111 , the reaction could be inhibited by an ADAM metallopeptidase domain 17 (Adam 17) active site inhibit

112 MerTK is susceptible to ADAM metallopeptidase domain 17 (ADAM17)-mediated cell-surfac

113 ng, we identified null mutations in the ADAM metallopeptidase domain 9 (ADAM9) gene in four consangui

114 rd lead concentration and expression of ADAM metallopeptidase domain 9 (ADAM9), reticulon 4 (RTN4), a

115 t of only two amino acid residues within the metallopeptidase domain of Yta12 allows its assembly int

116 n ATPase domain of the AAA family and an H41 metallopeptidase domain.

117 sACE comprises two homologous metallopeptidase domains, N and C, joined by an inter-do

118 tin (betaARRs) 1 and 2 and the transmembrane metallopeptidases ECE-1c and ECE-1d.

119 gene, which encodes a ubiquitously expressed metallopeptidase essential for the hydrolysis of dipepti

120 These metallopeptidases exhibit unique specificity for the sub

121 e otherwise unrelated astacin and fragilysin metallopeptidase families.

122 nding motif characteristic of members of the metallopeptidase family M16.

123 motif, His-X-X-Glu-His, that places it in a metallopeptidase family which includes the mitochondrial

124 rate specificities of two enzymes of the M64 metallopeptidase family, the IgA protease ThomasA from T

125 y O-acetylated-sialic acid (a key feature of metallopeptidases) for entry.

126 Fxna is a transmembrane metallopeptidase from family M28, localized to the endop

127 al sequence analysis predicted that it was a metallopeptidase from the presence of a motif conserved

128 Here we characterize a approximately 47 kDa metallopeptidase, from the hydrogenosome-bearing, unicel

129 While PvdM does not share the metallopeptidase function of renal dipeptidase, it still

130 d changes in the protein structure with Zn2+ metallopeptidase gene function.

131 xpression patterns for a group of fungalysin metallopeptidase genes, a gene family thought to be invo

132 vide support for MtfA as a prototypical zinc metallopeptidase (gluzincin clan).

133 me-2 (ECE-2), a member of M13 family of zinc metallopeptidases, has previously been shown to process

134 between HSV-1 egress, heparanase, and matrix metallopeptidases; identifies new molecular markers of i

135 e present study was to ascertain if Lit is a metallopeptidase, identify residues essential for Lit ac

136 ption of the growth inhibitor tolkin (tok, a metallopeptidase implicated in TGFbeta signalling).

137 IDE is an unusual metallopeptidase in that it is allosterically activated

138 nts the minimum structure of a Glu-zincin (a metallopeptidase in which the third zinc ligand is a glu

139 ting enzyme (ACE) are two key zinc-dependent metallopeptidases in the natriuretic peptide and kinin s

140 eatures characteristic of clan ME family M16 metallopeptidases, including an "inverted" HXXEH active

141 s significant sequence identity to mammalian metallopeptidases, including endothelin-converting enzym

142 on of collagen 1 alpha 1 (Col1a1) and tissue metallopeptidase inhibitor 1 (Timp1) as well as inflamma

143 lin (week 12: r=0.57; week 24: r=0.57), TIMP metallopeptidase inhibitor 1 (week 12: r=0.47; week 24:

144 not Leu, and were inhibited by conventional metallopeptidase inhibitors and some divalent cations.

145 Neprilysin is a metallopeptidase known to degrade amyloid in Alzheimer d

146 omains: an alpha+beta domain inserted in the metallopeptidase-like domain and a C-terminal circularly

147 firmed that CA_C2195 contained an N-terminal metallopeptidase-like domain.

148 2 protein consisted of a single, zincin-like metallopeptidase-like domain.

149 ntiation process through induction of matrix metallopeptidase (MMP)13.

150 ignaling and upregulation of multiple matrix metallopeptidases (MMP) by METDelta14Ex induced cytoskel

151 iR-181b showed that miR-181b enhanced matrix metallopeptidases (MMP)2 and MMP9 activity and promoted

152 with other peptidases, with only a putative metallopeptidase motif, H(160)EXXH, giving an indication

153 tidines as well as other residues within the metallopeptidase motif.

154 conserved H(149)E(150)XXH(153)+E(212)+Y(205) metallopeptidase motif.

155 h for structural models of integral-membrane metallopeptidases (MPs), we discovered three related pro

156 ocalized to the cell envelope; these include metallopeptidases, multidrug-resistant efflux (MDR) pump

157 It was identified as a metallopeptidase named "adipocyte-derived leucine" or "p

158 myloid-beta degrading enzyme, the endogenous metallopeptidase neprilysin, which is fused to albumin t

159 zymatic degradation by two membrane-bound Zn-metallopeptidases, neprilysin (NEP, EC 3.4.24.11) and am

160 A zinc metallopeptidase neurolysin (Nln) processes diverse bioa

161 The zinc metallopeptidase neurolysin is shown by x-ray crystallog

162 erall fold first seen in the closely related metallopeptidase neurolysin.

163 Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24

164 r discover widely distributed bacterial M16B metallopeptidases of previously unclear biological funct

165 activate the inner membrane-associated zinc metallopeptidase OMA1 that cleaves L-OPA1, causing S-OPA

166 copy gene in Arabidopsis thaliana, encodes a metallopeptidase originally identified via its affinity

167 y the specific cleavage of repressor DdrO by metallopeptidase PprI (also called IrrE).

168 e substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and

169 Suppressed metallopeptidases, reflected in low expression of carbox

170 One such is LasA, an M23 metallopeptidase related to autolytic glycylglycine endo

171 edicted that part of the protein contained a metallopeptidase-related domain.

172 Zswim5); and Adamts5 [a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin t

173 their substrates, three structurally related metallopeptidases require the specific recognition of O-

174 Zinc metallopeptidase STE24 (ZMPSTE24) is a transmembrane met

175 dases RAS Converting Enzyme1 (RCE1) and zinc metallopeptidase STE24 and lacks canonical CaaX activity

176 s-peptide bond are well conserved within the metallopeptidase subfamily M9B.

177 ts by several experts in the field of matrix metallopeptidases suggests that this approach will signi

178 This enzyme is a Zn-containing metallopeptidase that catalyzes the degradation of the m

179 I-converting enzyme (ACE, or DCP1) is a zinc metallopeptidase that converts angiotensin I into the va

180 n-degrading enzyme (IDE) is an atypical zinc-metallopeptidase that degrades insulin and the amyloid s

181 ndopeptidase (NEP) is a genetically distinct metallopeptidase that degrades the natriuretic peptides.

182 homolog of glutamate carboxypeptidase II, a metallopeptidase that has been intensively studied as a

183 ng enzyme-1 (ECE-1) is a membrane-bound zinc-metallopeptidase that is related to neprilysin in amino

184 ding enzyme (IDE) is a highly conserved zinc metallopeptidase that is ubiquitously distributed in hum

185 Thimet oligopeptidase (TOP) is a zinc metallopeptidase that metabolizes a number of bioactive

186 degrading enzyme (IDE) (insulysin) is a zinc metallopeptidase that metabolizes several bioactive pept

187 prin B (MB) is a multidomain type-I membrane metallopeptidase that sheds membrane-anchored substrates

188 nked homodimeric multidomain type-I membrane metallopeptidase that sheds membrane-bound cytokines and

189 .4.24.16) are closely related zinc-dependent metallopeptidases that metabolize small bioactive peptid

190 Homology of PEX to the M13 family of Zn2+ metallopeptidases which include neprilysin (NEP) as prot

191 amily of structurally-related Zn(2+)-binding metallopeptidases which play a major role in a wide rang

192 idue propeptide, the shortest reported for a metallopeptidase, which lacks cysteines.

193 hrrP encodes an M16A family metallopeptidase whose catalytic activity is required fo

194 imental evidence that it is a zinc-dependent metallopeptidase with a catalytic mechanism similar to t

195 ; 20 min) hexameric ( approximately 270-kDa) metallopeptidase with a pH optimum of 8.5 to 9.5.

196 x) proteins and a reduction of ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1), an

197 used by an autoantibody to a disintegrin and metallopeptidase with thrombospondin type 1 motif 13 (AD

198 cterized by low ADAMTS13 (A Disintegrin-like Metallopeptidase with ThromboSpondin type 1 motif 13) ac

199 hydrogenase 2 family member], ADAMTS13 [ADAM metallopeptidase with thrombospondin type 1 motif 13], a

200 hout known mechanism, such as ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif, 13) f

201 cted two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) a

202 d Pyrococcus furiosus carboxypeptidase--zinc metallopeptidases with no detectable sequence similarity