ライフサイエンスコーパス: metalloprotease

1 , which encodes a putative membrane-embedded metalloprotease.

2 tsH1, a homolog of a bacterial membrane AAA+ metalloprotease.

3 after 8 h and was coding for a transmembrane metalloprotease.

4 rich Mucin-like protein and a Zinc-dependent metalloprotease.

5 a complex with the p97 ATPase and the SPRTN metalloprotease.

6 decorin, collagens, fibronectin, and matrix metalloproteases.

7 flammatory response and inhibition of matrix metalloproteases.

8 hem is resistant to shedding by cell surface metalloproteases.

9 ge takes place on the cell surface by matrix metalloproteases.

10 of the M16A family of soluble zinc-dependent metalloproteases.

11 embrane and is carried out by membrane-bound metalloproteases.

12 igh selectivity for the bacterial over human metalloproteases.

13 We used matrix metalloprotease-1 (MMP1) as a model system to study the

14 he catalytic and hemopexin domains of matrix metalloprotease-1 (MMP1) on type 1 collagen fibrils corr

15 expression of alpha1 type I collagen, matrix metalloprotease-1, and platelet-derived growth factor-be

16 The MMP-9/ tissue inhibitor of metalloproteases-1 (TIMP-1) complex presents as a major

17 as dependent on the sheddase disintegrin and metalloprotease 10 (ADAM10) and the gamma-secretase comp

18 A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein e

19 A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed

20 anchored metalloproteinase a disintegrin and metalloprotease 10 (ADAM10) is required for shedding of

21 ne of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretas

22 was abrogated by an ADAM (A disintegrin and metalloprotease) 10 and 17 selective inhibitor, but not

23 s process is mediated by the upregulation of metalloprotease 13 (MMP13).

24 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in experimental hyp

25 ired for the maturation of A disintegrin and metalloprotease 17 (ADAM17, also called TACE), which is

26 metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signali

27 he metalloprotease ADAM17 (a disintegrin and metalloprotease 17) is a key regulator of tumor necrosis

28 he metalloprotease ADAM17 (a disintegrin and metalloprotease 17) regulates EGF-receptor and TNFalpha

29 l-surface metalloprotease, a disintegrin and metalloprotease-17 (ADAM17), and into ADAM17 hypomorphic

30 ase 9 (MMP9) as well as activation of matrix metalloprotease 2 (MMP2) and MMP9, whereas the ED peptid

31 ved growth factor subunit B) and MMP (matrix metalloprotease) 2/MMP14.

32 ide (NO) production, which stimulates matrix metalloprotease-2 (MMP-2) and MMP-9 activity in the extr

33 nnexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the extracel

34 on and slow degradation of lamin-A by matrix-metalloprotease-2 (MMP2), and inhibition of this lamin-A

35 d upregulation of tissue inhibitor of matrix metalloprotease-2 (TIMP2).

36 itically regulated by the activity of matrix metalloprotease 3 (MMP-3), in contrast to NMDAR-dependen

37 luding TNF-alpha, IL-12p40 and high level of metalloprotease 9 (MMP-9) at the late stages of disease.

38 The collagenase matrix metalloprotease 9 (MMP-9), which is increased in patient

39 ssion of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9).

40 tion, NO-dependent S-nitrosylation of matrix metalloprotease 9 (MMP9) as well as activation of matrix

41 expression of NF-kappaB target genes matrix metalloprotease 9 and interleukin 6.

42 use, oxidative stress activated MMP9 (matrix metalloprotease 9) via its redox-responsive regulatory s

43 udy, we investigate the potential for matrix metalloprotease-9 (MMP-9), an endopeptidase secreted in

44 ected Wsh mice had reduced amounts of matrix metalloprotease-9 in BALF and were resistant to epitheli

45 Matrix metalloprotease-9 may thus enhance overall excitatory/in

46 Our data suggest that this protease, matrix metalloprotease-9, increases branching of excitatory neu

47 ce proteins A and C (PspA and PspC) and zinc metalloprotease A and B (ZmpA and ZmpB) proteins.

48 receptor on NK cells that is cleaved by the metalloprotease a disintegrin and metalloproteinase-17 u

49 asing enzyme, the transmembrane cell-surface metalloprotease, a disintegrin and metalloprotease-17 (A

50 ns of the substrates, which in turn regulate metalloprotease access to the substrates' ectodomain and

51 An extracellular metalloprotease (AcPs) with high milk-clotting activity

52 l of a dynamical model of P. fluorescens 07A metalloprotease active and inactive conformations.

53 Furthermore, AQP-1 enhances matrix metalloprotease activity and colocalizes with phosphoryl

54 Intracellular metalloprotease activity controls intraneuronal Abeta ag

55 ent with IL-1 significantly increased matrix metalloprotease activity in the conditioned media of eGF

56 rofiling revealed that putative residues for metalloprotease activity within MroQ are required for it

57 at two alpha-sites through a disintegrin and metalloprotease (ADAM) and at one beta-site through BACE

58 ally active members of the A Disintegrin And Metalloprotease (ADAM) family of membrane-anchored metal

59 urface by proteases in the A Disintegrin And Metalloprotease (ADAM) family.

60 talloproteinase (MMP)- and a disintegrin and metalloprotease (ADAM)-family zinc metalloproteases mark

61 Ectodomain shedding by the metalloprotease ADAM10 and lysosomal degradation generat

62 his paper, we report a specific role for the metalloprotease ADAM10 on B cells in regulating both ICO

63 toxin(4)-a pore-forming toxin that binds the metalloprotease ADAM10 on the surface of a broad range o

64 The transmembrane metalloprotease ADAM10 sheds a range of cell surface pro

65 is facilitated by the ITCH E3 ligase and the metalloprotease ADAM10, both of which are also secreted

66 hese tetraspanins directly interact with the metalloprotease ADAM10, regulate its exit from the endop

67 PrP(C) is shed at the plasma membrane by the metalloprotease ADAM10, yet the impact of this on prion

68 rocytes by increasing the active form of the metalloprotease ADAM10.

69 ylated sugars on N-glycoproteins such as the metalloprotease Adam10.

70 Here we demonstrate that the metalloproteases ADAM10 and ADAM17 can produce sgp130 by

71 d from the cell surface by a disintegrin and metalloprotease, ADAM10.

72 The metalloprotease ADAM17 (a disintegrin and metalloproteas

73 The metalloprotease ADAM17 (a disintegrin and metalloproteas

74 eighboring cells that depend on the membrane metalloprotease ADAM17 and EGFR activity.

75 ow that TIMP3 acts through inhibition of the metalloprotease ADAM17 and HB-EGF to regulate cerebral a

76 cally, we found that fibulin-3 activates the metalloprotease ADAM17 by competing with its endogenous

77 can be shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble peptide wit

78 ate the NRG1-ErbB4 pathway, possibly via the metalloprotease ADAM17, in skeletal muscle of diet-induc

79 expression and phosphorylation ratio of the metalloprotease ADAM17, which is involved in NRG1 sheddi

80 rates make them resistant to shedding by the metalloprotease ADAM17.

81 dding from neutrophils via activation of the metalloprotease ADAM17.

82 ctor) inflammatory pathway, triggered by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-me

83 cts toward the other tested Zn(2+)-dependent metalloproteases (ADAMs and meprins).

84 lecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated with high substrat

85 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs) releases many important biologi

86 ssive cleavage of large VWF multimers by the metalloprotease ADAMTS-13 in an LVAD-driven circulation.

87 Mice lacking aggrecan or the metalloprotease ADAMTS1, which degrades proteoglycans, d

88 The metalloprotease ADAMTS13 (a disintegrin and metalloprote

89 The metalloprotease ADAMTS13 regulates blood coagulation by

90 VWF is regulated by the metalloprotease ADAMTS13, which in turn is conformationa

91 function is proteolytically regulated by the metalloprotease ADAMTS13.

92 Recessive mutations in the secreted metalloprotease ADAMTS17 cause ectopia lentis and short

93 The secreted metalloprotease ADAMTS9 has dual roles in extracellular

94 Here, homologous secreted metalloproteases ADAMTS9 and ADAMTS20 are identified as

95 s, have provided opportunities for mimicking metalloprotease and for bridging the gap between natural

96 The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors bot

97 as well as by increased expression of matrix metalloproteases and bone-specific proteases.

98 osis and tissue remodeling, including matrix metalloproteases and collagen, were upregulated in chron

99 ch protrusive organelles that secrete matrix metalloproteases and degrade the extracellular matrix.

100 ion were assessed in vitro on a set of human metalloproteases and displayed high affinity and selecti

101 tor p300, preventing the induction of matrix metalloproteases and other p300-dependent genes required

102 tating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6).

103 ulates two functional forms of RANKL through metalloproteases and the JAK2/STAT5 pathway, and it help

104 Synergy between inhibitors of matrix metalloproteases and TMPRSS2 suggests that both host pro

105 s generated at the plasma membrane by matrix metalloproteases and transferred to the cell nucleus via

106 increase in proliferation and expression of metalloproteases, and invasive epithelium.

107 F-beta1, collagen I, fibronectin, and matrix metalloproteases, and plasma PAI-1 levels correlated wit

108 other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxicity aga

109 and researcher, especially regarding meprin metalloproteases; and 3) my participation in communities

110 Here, we show that both lectican-degrading metalloproteases are present in these brain regions and

111 oprotease (ADAM) family of membrane-anchored metalloproteases are synthesized as proenzymes, in which

112 We observe increased expression of matrix metalloproteases as well as decreased expression of tiss

113 me profiling identifies a gene encoding a Zn-metalloprotease, as a candidate effecting copper recycli

114 ne, which encodes variants of the mTLD/BMP-1 metalloproteases, as a critical regulator of alpha3beta1

115 virulence-related protein families, such as metalloproteases-associated paralogs, were exclusively i

116 Among a panel of metalloproteases, BDM44768 selectively inhibits IDE.

117 codes a mitochondria-localized ATP-dependent metalloprotease belonging to the FILAMENTATION TEMPERATU

118 ECM degradation requires metalloproteases, but whether other enzymes are required

119 ific proteases, including complement, matrix metalloproteases, caspases, and granzymes, and carried b

120 ange of the dimerization partners that allow metalloprotease cleavage in the extracellular space.

121 We identify the metalloprotease cleavage site 3 aa upstream of the predi

122 Notch activation requires unmasking of a metalloprotease cleavage site remote from the site of li

123 regulatory switch results in sensitivity to metalloprotease cleavage, and bound ligands induce Notch

124 Metalloprotease-cleaved CD95L (cl-CD95L) is released int

125 ADAMTS13 metalloprotease cleaves von Willebrand factor (VWF), the

126 decreased expression of tissue inhibitor of metalloproteases confined to sinusoidal endothelial cell

127 iotensin-I converting enzyme (ACE) is a zinc metalloprotease consisting of two catalytic domains (N-

128 We found that the isoform associates with metalloprotease-containing exosomes and stimulates their

129 Adam13/33 is a cell surface metalloprotease critical for cranial neural crest (CNC)

130 High expression levels of ADAM8, a metalloprotease disintegrin, are correlated with poor cl

131 AMDEC1 is a proteolytically active metzincin metalloprotease displaying rare active site architecture

132 oprotease to spacer domains reveals that the metalloprotease domain exhibits a latent conformation in

133 ese rare structural features in the ADAMDEC1 metalloprotease domain impact the proteolytic activity,

134 ns that generate DPCs and that the catalytic metalloprotease domain of CaWss1 is essential for its ce

135 ease domains of these toxins and the related metalloprotease domain of clostridial neurotoxins.

136 lly designed amino acid substitutions in the metalloprotease domain of wild type (wt) BoNT/C1.

137 to VWF allosterically activates the adjacent metalloprotease domain to facilitate proteolysis.

138 t pro-domain processing between the pro- and metalloprotease domain, but nevertheless, cause signific

139 heddase molecule, ADAM 10 (A disintegrin and metalloprotease domain-containing protein 10).

140 ergence in substrate specificity between the metalloprotease domains of these toxins and the related

141 daptor molecule (STAM) (AMSH) is a conserved metalloprotease DUB in eukaryotes.

142 h basement membrane in the absence of matrix metalloproteases during its developmental invasion.

143 the catalytic domain of the light chain (LC) metalloprotease (E224 > A and Y366 > A), designed to pro

144 n this study, we found that an extracellular metalloprotease encoded by impA (PA0572) is under the re

145 ts to develop potent compounds against these metalloproteases failed to achieve selectivity against h

146 ved by members of the disintegrin and matrix-metalloprotease family that are increased in the aqueous

147 Tiki represents a new metalloprotease family that is dependent on Mn(2+)/Co(2+

148 ed DNA-dependent and DNA replication-coupled metalloprotease for DPC repair.

149 our knowledge, this is the first report on a metalloprotease from T. clypeatus, and the results indic

150 o-Pro endopeptidase-1 (PPEP-1) is a secreted metalloprotease from the bacterial pathogen Clostridium

151 status of the PsbP-like protein and the zinc metalloprotease FtsH as well as the presence of high sal

152 cus aureus, the membrane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance

153 like proteins and a 70-kD ATP-dependent zinc metalloprotease, FtsH.

154 erize the genomic organization of duplicated metalloprotease genes (patristacins) recruited into the

155 Metalloprotease gp63 (Leishmania donovani gp63 (Ldgp63))

156 Secreted metalloproteases have diverse roles in the formation, re

157 Metzincin metalloproteases have major roles in intercellular commu

158 om degradation by the symbiotically relevant metalloprotease HrrP (host range restriction peptidase),

159 Intramembrane metalloproteases (IMMPs) are conserved from bacteria to

160 dynamics of the Pseudomonas fluorescens 07A metalloprotease in the presence of structural Ca(2+) and

161 role of selected serine proteases and matrix metalloproteases in chemokine processing has long been k

162 RNF213 down-regulated expressions of matrix metalloproteases in endothelial cells, but not in fibrob

163 of the inner membrane-embedded ATP-dependent metalloproteases in mitochondria of Arabidopsis (Arabido

164 nduces expression of the Tissue inhibitor of metalloproteases in the haltere, which prevents the basa

165 with 1-NM-PP1, indicating a role for matrix metalloproteases in TrkA activation.

166 urons, and expression of wild-type but not a metalloprotease-inactive version of pappaa restores habi

167 Metalloproteases, including endothelin-converting enzyme

168 Consistent with other zinc metalloproteases, including thermolysin, ZMPSTE24 prefer

169 rmacological inhibition of the ECE family of metalloproteases increased intracellular and extracellul

170 sphorylation was reduced after inhibition of metalloprotease-induced IL-15Ralpha-IL-15 shedding from

171 tors that stimulate the production of matrix metalloprotease, inflammatory cell recruitment, and dend

172 Suppression of virus by metalloprotease inhibition varied among tested cell line

173 deficient mice demonstrate the redundancy of metalloprotease inhibitor function in embryonic and post

174 ge of LTBP4 was efficiently inhibited by the metalloprotease inhibitor TIMP-4, but not by TIMP-1 and

175 Actinonin, a non-specific matrix metalloprotease inhibitor, improved recovery of the part

176 Thus, natural metalloprotease inhibitors are crucial regulators of cho

177 st exploited strategy to develop potent zinc-metalloprotease inhibitors relies on a core zinc chelato

178 Matrix metalloprotease inhibitors suppressed S-mediated cell-ce

179 lved to escape from inhibition by endogenous metalloprotease inhibitors.

180 nd metalloproteinase domain 10 (ADAM10) is a metalloprotease involved in cleavage of various cell sur

181 Meprin beta is a membrane-bound metalloprotease involved in extracellular matrix assembl

182 (MT1-MMP or MMP-14) is a zinc-transmembrane metalloprotease involved in the degradation of extracell

183 se-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc metalloproteases involved in the degradation of aggrecan

184 The SPRTN metalloprotease is essential for DNA-protein crosslink (

185 Secretion of exosomes and metalloproteases is essential for extracellular matrix r

186 ight that SPRTN, a specialized DNA-dependent metalloprotease, is a central player in proteolytic clea

187 d that MT2-MMP, another abundantly expressed metalloprotease, is also invadopodia associated.

188 Ste24, an integral membrane protein zinc metalloprotease, is found in every kingdom of eukaryotes

189 PAPP-AA encodes an extracellular metalloprotease known to increase IGF bioavailability, t

190 AdamTS proteins are extracellular metalloproteases known to modify ECM proteins and promot

191 tory pathways involving inhibition of matrix metalloproteases, liver X receptor/retinoid X receptor,

192 Human ADAMTS13 has a short propeptide, metalloprotease (M), disintegrin-like (D), thrombospondi

193 Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondi

194 of membrane RANKL through downregulation of metalloproteases mainly a disintegrin and metalloprotein

195 egrin and metalloprotease (ADAM)-family zinc metalloproteases markedly decreased both entry and cell-

196 Upon siRNA-mediated knockdown of the astacin metalloprotease meprin beta, the levels of the alternati

197 analysis highlighted induction of the matrix metalloprotease MMP-10 and the extracellular matrix prot

198 ellular matrix proteases ADAMTS-5 and matrix metalloprotease (MMP) -3, -7, and -13.

199 Matrix metalloprotease (MMP)-14-mediated Tie2 ectodomain sheddi

200 nd were analysed for a panel of novel matrix metalloprotease (MMP)-degraded ECM proteins, by ELISA-ba

201 Matrix metalloprotease (MMP)-degraded type I collagen (C1M), ty

202 loss in Smoc2(-/-) mutants, reducing matrix metalloprotease (Mmp)9.

203 7C, a transcriptional repressor of membrane metalloproteases (MMP).

204 ir phagocytic rate, without affecting matrix metalloproteases (MMP)2 and MMP9 activity.

205 es, including IL-1beta, and the pro-invasive metalloprotease, MMP-9.

206 JNK signaling activates a matrix metalloprotease (MMP1) to promote Notch-induced tumorige

207 se in the activity of membrane type-1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G pro

208 , by decreasing the expression of the matrix metalloprotease MMP9.

209 Matrix Metalloproteases (MMPs) are an important family of prote

210 Matrix metalloproteases (MMPs) MMP-2 and MMP-9 have been implic

211 Matrix metalloproteases (MMPs) regulate innate immunity acting

212 Therapeutically inhibiting matrix metalloproteases (MMPs) suppressed both IMPAD1- and KDEL

213 eavage is mediated by upregulation of matrix metalloproteases (MMPs) that accompanies higher HPSE exp

214 Applied to matrix metalloproteases (MMPs) with highly conserved catalytic

215 depends on extracellular signaling by matrix metalloproteases (MMPs), but it is unknown how this cata

216 cluding neutrophil elastase and MMPs (matrix metalloproteases), modulate cell signaling, inflammation

217 s dependent on Mn(2+)/Co(2+) but lacks known metalloprotease motifs.

218 Here we investigated the role of the metalloprotease Mpl in the dissemination process.

219 e in PlcB processing and vacuole escape, the metalloprotease Mpl is required for ActA processing and

220 The pattern of expression of metalloproteases (MPs) was analyzed by single-cell rever

221 The membrane-anchored matrix metalloprotease MT1-MMP is a potent collagenolytic enzym

222 cle cargo such as the membrane-type 1 matrix metalloprotease (MT1-MMP) to shedding microvesicles.

223 ce the surface expression of membrane type 1 metalloprotease (MT1-MMP) via down-regulating the kinesi

224 endent recycling of the transmembrane matrix metalloprotease, MT1-MMP to promote invasive behaviour l

225 matrix invasion activity by recycling matrix metalloprotease, MT1-MMP.

226 We conclude that zinc metalloproteases must be considered potential contributo

227 n and missense mutations in MME encoding the metalloprotease neprilysin in 19 index case subjects dia

228 erine hydrolases, cysteine proteases, matrix metalloproteases, nitrilases, caspases, and histone deac

229 oteolytically cleaved by membrane-associated metalloproteases of the ADAM family, leading to the shed

230 embrane depolarization and activation of the metalloprotease OMA1, to prevent extreme mitochondrial f

231 itors of cysteine proteases, acid proteases, metalloproteases, or aminopeptidases abolished the effec

232 cer biomarkers shed from the cell surface by metalloproteases overexpressed in numerous cancers.

233 As a secreted metalloprotease, Pappaa stimulates extracellular insulin

234 ulated folding, using the endogenous E. coli metalloprotease PepQ.

235 ion and fibrous cap thinning, by heightening metalloprotease production.

236 Both murine Notch1 and Notch2 require the metalloprotease protease Adam17, but not Adam10 during l

237 ptidoglycan (PG) chemotypes by secreting the metalloprotease pseudoalterin.

238 s the production of reactive oxygen species, metalloprotease release, and chemotaxis.

239 The M1 family of metalloproteases represents a large number of exopeptida

240 d by defects in MBTPS2, which encodes site-2 metalloprotease (S2P).

241 Activation of Wss1 results in metalloprotease self-cleavage and proteolysis of associa

242 This induces ectodomain shedding of metalloprotease-sensitive cell surface proteins.

243 conjugated to tumor-targeting antibodies via metalloprotease-sensitive linkers.

244 IA-negative S. epidermidis 1457Deltaica, the metalloprotease SepA is required for Aap-dependent S. ep

245 duced synaptic enlargement depends on matrix metalloprotease signaling in the extracellular matrix (E

246 rocess, we examined the localisation of FtsH metalloproteases, some of which are directly involved in

247 leavage activity than 1,10-phenanthroline, a metalloprotease-specific inhibitor.

248 Here we identify the metalloprotease SPRTN as the DPC protease acting in meta

249 Recent studies implicate the metalloprotease SPRTN in S phase removal of DPCs, but ho

250 removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication

251 kr1/Ltn1, Hrd1, and the Asi complex) and the metalloprotease Ste24 in induced models of ER stress.

252 d degradation ubiquitin ligase Hrd1 and zinc metalloprotease Ste24, promote degradation of characteri

253 erevisiae that highlighted a role for the ER metalloprotease Ste24.

254 ese methods in predicting caspase and matrix metalloprotease substrate-cleavage sites.

255 peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid pepti

256 CSN5 is the zinc metalloprotease subunit of the COP9 signalosome (CSN), w

257 ve examined the role of the conserved Rpn11p metalloprotease subunit of the proteasome, which couples

258 further matured via proteolytic cleavage by metalloproteases such as ADAM17, a process known as shed

259 nM) and a weak inhibitor of other mammalian metalloproteases such as TNFalpha converting enzyme (TAC

260 The metalloprotease TACE (tumor necrosis factor alpha conver

261 Amberg Johnson et al. (2017) identified the metalloprotease TgFtsH1 as the target of actinonin in th

262 derived from cortical neurons, and ADAM10, a metalloprotease that cleaves CX3CL1 into a secreted form

263 xperiments show that the activity of Oma1, a metalloprotease that cleaves Opa1, is regulated by short

264 0) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions f

265 -Like, SWIRM, and MPN domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiqui

266 II secretion system effector, termed NleD, a metalloprotease that inactivates MAPKs by specifically c

267 , the protein encoded by SPRTN, is a nuclear metalloprotease that is involved in the repair of DNA-pr

268 rescued by overexpression of Kuzbanian, the metalloprotease that mediates the Notch S2 cleavage.

269 ) with increased expression of the ADAM10/17 metalloprotease that promotes trans-signaling by the sol

270 om2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cyto

271 We also identify two inhibitors of host metalloproteases that block S-mediated cell-cell fusion,

272 le hydrophobic S1' specificity pocket of the metalloprotease thermolysin with purposefully designed l

273 Here, we show that the tissue inhibitors of metalloprotease (TIMP) gene family is essential for norm

274 Tissue inhibitor of metalloprotease (TIMP)-3 was expressed in CD146(+) TSCs

275 or batimastat but not by tissue inhibitor of metalloproteases (TIMP)-1, TIMP-2, or the N-terminal inh

276 mediated by activation of the tmTNF cleavage metalloprotease TNF-alpha-converting enzyme via p38 MAP

277 lated NK cells increases the activity of the metalloprotease TNF-alpha-converting enzyme.

278 The crystal structure of the ADAMTS13 metalloprotease to spacer domains reveals that the metal

279 ere, we report that the BMP-1/Tolloid family metalloprotease Tolkin (Tok) is responsible for Slit pro

280 C. piperi sequences encode a novel family of metalloprotease toxins that are distantly related to BoN

281 strates are associated with their respective metalloproteases under both basal or cleavage-stimulated

282 es and MHV S proteins, suggesting a role for metalloprotease use in strain-dependent tropism.

283 as Streptococcus pneumoniae secrete a giant metalloprotease virulence factor responsible for cleavin

284 The upregulation of DC-STAMP and matrix metalloproteases was observed on these cells and may rep

285 cluding the up-regulation of multiple matrix metalloproteases, which are known to be critical for the

286 eptidase STE24 (ZMPSTE24) is a transmembrane metalloprotease whose catalytic activity is critical for

287 Further, blockade of matrix metalloprotease with BB-94 inhibited eotaxin-1-induced T

288 ses were confirmed to be serine protease and metalloprotease with molecular weight (MW) of 44 and 108

289 ne network of ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) genes as cen

290 metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats membe

291 re deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, memb

292 rotein S, antithrombin and A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats-13 (A

293 The yeast metalloprotease Wss1 clears chromatin-bound sumoylated p

294 unction that had only been attributed to the metalloprotease Wss1 in budding yeast.

295 n this proteolytic pathway involves the zinc metalloprotease YaeL; V. cholerae cells lacking YaeL acc

296 known chelators that can disrupt the BoNT/A metalloprotease zinc-containing active site, thus impedi

297 hat the protrusion is enriched in the matrix metalloprotease ZMP-1 and transiently expands AC volume

298 ic cleavage of CD2831 and CD3246 by the zinc metalloprotease ZmpI, whose expression is controlled by

299 The integral membrane zinc metalloprotease ZMPSTE24 is important for human health a

300 of HIV protease inhibitors on the human zinc metalloprotease ZMPSTE24.