ライフサイエンスコーパス: metallothionein

1 ctivity and availability of free Zn(II) from metallothionein.

2 r Ca2+ decay, all of which were nullified by metallothionein.

3 elated protein biomarkers were attenuated by metallothionein.

4 rich region, with similarity to a Drosophila metallothionein.

5 eater than 1:1 with the cysteine residues of metallothionein.

6 redox and metal-binding states of mammalian metallothionein.

7 enic, thereby defining a functional role for metallothionein.

8 rsed by IL-22 treatment via the induction of metallothionein.

9 dismutase (SOD1), and mammalian zinc-bonded metallothionein.

10 f this protein functions as a copper-binding metallothionein.

11 y (designated as CvMT-I) of alphabeta-domain metallothioneins.

12 is likely bound to cytosolic proteins, like metallothioneins.

13 pper bound to cysteine-rich proteins such as metallothioneins.

14 us stimulation of PRRs induces expression of metallothioneins.

15 o the regulation of the metal response gene, metallothionein 1 (MT1), and defined the reproductive be

16 on the injury context and it is mediated by metallothionein 1 (MT1)-driven modulation of resistance

17 sed expression of antioxidant genes, such as metallothionein 1 (Mt1).

18 a7, and Slc39a8, and decreased expression of metallothionein 1 and 2.

19 proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- t

20 ings, these results suggest that blockade of metallothioneins 1 and 2 constitutes a promising approac

21 vivo We found that concomitant abrogation of metallothioneins 1 and 2 results in activation of the Ak

22 secretory leukocyte protease inhibitor, and metallothioneins 1 and 2.

23 The zinc-sensitive gene metallothionein-1 (MT-1 was up-regulated 7-fold, the opp

24 pathway is crucial for maintaining cellular metallothionein-1 levels to counteract ROS accumulation,

25 We report that human metallothionein 1a, well-known to coordinate 7 Zn(2+) or

26 interleukin-6 (IL-6; 14-fold, P < 0.001) and metallothionein-1A (MT-1A; 187-fold, P < 0.001) mRNA exp

27 such as versican, and novel ones, including metallothionein 1E (MT1E) and nicotinamide N-methyltrans

28 Here, we show that human metallothionein 1G (hMT1G) promoter is upregulated by E2

29 P binding cassette subfamily A member 1, and metallothionein 1M genes.

30 uses stable isotopically enriched (67)Zn(7) metallothionein 2 ((67)Zn(7)-MT-2) to quantitatively det

31 Cd(4)-alpha-domain was prepared from rabbit metallothionein-2 (MT 2), and its three-dimensional stru

32 ls by acting as a receptor for extracellular metallothionein-2.

33 ed increased activity of the zinc-responsive metallothionein 2a (MT2a) promoter when ZnT5b was co-exp

34 Metallothionein 2A, a known CP-r gene, was among these 1

35 Metalation and demetalation of human metallothionein-2A (MT) with Cd(2+) is investigated by u

36 es and the mechanism for metalation of human metallothionein-2A (MT), an intrinsically disordered pro

37 1 (Uhmk1), insulin-induced gene 1 (Insig1), metallothionein 3 (Mt3), tetraspanin 2 (Tspan2), peroxir

38 hese treatments, three of these, neuronatin, metallothionein 3 and cystatin E/M, were frequently hype

39 (2)O(2) enhances cytosolic zinc content in a metallothionein-3 (MT-3)-requiring manner.

40 showed increased staining for PSMD11 and the metallothioneins 5 days post-SCI, along the peripheral r

41 Increased protein levels for PSMD11 and the metallothioneins 5 days post-SCI, specifically along the

42 -throughput RNAi screening of the Drosophila Metallothionein A (MtnA) promoter.

43 ly weakly bound, with a log K of 7.7, making metallothionein a zinc donor in the absence of thionein.

44 contrasting agent for TEM, we have evaluated metallothionein, a small metal-binding protein, reacted

45 Metallothioneins, a group of cysteine-rich metal-ion bin

46 CXC), general stress (HSP70), metal-binding (metallothionein-A), and xenobiotic metabolism (Cyp1a1) u

47 or glutathione-related mechanisms, including metallothionein, across multiple populations.

48 partially mimicked the effects of glucose on metallothionein, although not ZiP, gene expression.

49 rophy were dramatically up-regulated (lipin, metallothionein, AMP deaminase, RNA helicase-related pro

50 s involved in copper homeostasis may include metallothionein and amyloid precursor protein.

51 Immunohistochemistry showed that metallothionein and keratin 14 proteins were overexpress

52 mediated through reductive zinc insertion by metallothionein and subsequent proteolysis involving a c

53 olecular structures and redox chemistries of metallothionein and thionein determine Zn(II) availabili

54 d system to identify a putative cotton fiber metallothionein and to confirm it as a protein that coul

55 te immune responses, with a central role for metallothioneins and autocrine/paracrine signaling via A

56 nes in the ABOi and HLAi groups consisted of metallothioneins and epithelial transporter genes.

57 efenses (catalase, glutathion S-transferase, metallothionein), and genotoxicity are the most sensitiv

58 ranscripts included serum amyloid A1 and A2, metallothionein, and apolipoprotein D.

59 xpressed significantly higher levels of p21, metallothionein, and hemoglobin alpha1 proteins by Weste

60 ensitive mutants, cup1Delta cells lacking Cu-metallothionein, and particularly sod1Delta cells lackin

61 centration in brain is in part controlled by metallothionein, and zinc is released in the hippocampus

62 ledge of the evolutionary diversification of metallothioneins, and indicate differences in metal-bind

63 se in gene expression of UPP components, the metallothioneins, and the protease inhibitor, SLPI, with

64 Metallothioneins are a family of small, cysteine rich pr

65 Metallothioneins are considered to be the primary player

66 Ferritins and metallothioneins are known to sequester intracellular ir

67 Metallothioneins are potential markers of neurologic dis

68 Metallothioneins are proteins that are involved in intra

69 Metallothioneins are strongly suspected to participate i

70 Metallothioneins are typically low relative molecular ma

71 (II), cause dissociation of Zn(II) ions from metallothionein at pH 7.4 (Zn(7)T <==> Zn(7-n)T + nZn(2+

72 Expression of metallothionein B, which has known roles in inflammation

73 -induced transcription at an inducible gene, metallothionein B.

74 Importantly, the beneficial effects of metallothionein blockade on muscle mass and function was

75 We therefore investigated the effect of metallothionein blockade on skeletal muscle anabolism in

76 Pase efflux pump (Bxa1) and an intracellular metallothionein (BmtA).

77 These genes include metallothionein, cadherin and iroquois gene families, as

78 yte viability, such as BCL2-related protein, metallothioneins, CD71, and SOCS3, was up-regulated at 4

79 re and a dimension that exceeded the size of metallothionein clusters.

80 duction of genes encoding the Cu-detoxifying metallothionein (Cmt) proteins.

81 ne the influence of protein concentration on metallothionein conformation, the isolated Cd(4)-alpha-d

82 Overexpression of metallothioneins correlated with measures of disease pro

83 at thionein, the reduced, metal-free form of metallothionein, could function as a reducing system for

84 lymer chains using the N- and C-termini of a metallothionein derived from a pea plant.

85 A second extensive subfamily of oyster metallothioneins (designated as CvMT-II) has apparently

86 Several epithelial transporters and metallothioneins discriminate subclinical antibody-media

87 hat are unable to produce the major forms of metallothionein do not produce lead inclusion bodies, wh

88 Metallothionein expression during disease progression an

89 These results demonstrate dysregulated metallothionein expression in ascending aortic smooth mu

90 s, our findings implicate a role of elevated metallothionein expression in the clinical behavior of M

91 In vitro studies indicated that metallothionein expression is regulated in response to o

92 lls are stimulated continually through PRRs; metallothionein expression was up-regulated in human and

93 of Slc39a6 and Slc39a7 but not Slc39a8, nor metallothionein expression.

94 opper toxicity and fail to up-regulate MtnA (metallothionein) expression in response to excess Cu.

95 ents and control donors; 8 were genes of the metallothionein family.

96 down-regulated lncRNAs and 8 down-regulated metallothionein-family genes are significantly associate

97 ied by a unique ultrastructure and by copper-metallothionein fluorescence.

98 d in the ubiquitin proteasome pathway (UPP), metallothionein function, and protease inhibition.

99 fish Danio rerio, evaluated by assessment of metallothionein gene (mt2) expression, was reduced in th

100 Metallothionein gene expression and protein expression w

101 plementation increases intestinal copper and metallothionein gene expression, and Ctr1 protein levels

102 othesize that this is due to similarities in metallothionein gene expression.

103 ding possible metal-binding ligands from the metallothionein gene family, and a P-type ATPase that is

104 integration of avian retrovirus DNA into the metallothionein gene, before and after its induction to

105 including a metal response element from the metallothionein gene, contribute to the reporter inducti

106 A type 2 metallothionein gene, SsMT2, was cloned from Suaeda sals

107 We identified two metallothionein genes (CMT1 and CMT2), encoding cysteine

108 A binding, and transcriptional activation of metallothionein genes (MT genes) by MTF-1.

109 Metallothionein genes are highly expressed under various

110 lammatory genes and strongly induces several metallothionein genes encoding anti-inflammatory and ant

111 tor-1 (MTF-1) was required for regulation of metallothionein genes in human MDMs.

112 ans-eQTL near SLC39A8 regulating a module of metallothionein genes in LPS-stimulated monocytes.

113 propriate expression level of the endogenous metallothionein genes is achieved only when the activiti

114 We exploited the robust response of the metallothionein genes to heavy metal as a model for tran

115 Metallothionein genes were significantly overexpressed i

116 ary for basal and zinc-induced expression of metallothionein genes.

117 for basal and zinc-induced transcription of metallothionein genes.

118 Finally, an earthworm metallothionein-GFP construct could be activated in C. e

119 Finally, metallothionein-gold complexes visualized in the TEM sho

120 nts with a polymorphism in a gene regulating metallothionein had lower platinum concentrations and sh

121 Oyster metallothioneins have been characterized as cDNA and as

122 ction significantly decreased zinc-dependent metallothionein I (MT-I) gene transcription without alte

123 Metallothionein I and II are small metal binding protein

124 d in their accumulation; and 2) unlike mouse metallothionein I and zip4 mRNAs, the abundance of zip1,

125 Metallothionein I as a direct link between therapeutic h

126 croglia and the Bergmann glial expression of metallothionein I/II and the hyaluronan receptor CD44 we

127 on factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals.

128 The robust induction of metallothionein-I and II (MT-I and MT-II) genes by sever

129 ssociation of transcription factors with the metallothionein-I promoter was examined using chromatin

130 Recently, we found that metallothionein-I/-II double knockout (metallothionein-n

131 hionein IIa to five times higher levels than metallothionein Ig.

132 Lens metallothioneins (Ig, If, Ih, Ie, and IIa) and alpha-cry

133 n of cyan fluorescent protein (CFP), chicken metallothionein II (MT-II), and yellow fluorescent prote

134 Chemoattraction toward a gradient of metallothionein II was calcium-dependent, required the e

135 In these in vivo studies, metallothionein II was shown to enhance epidermal nerve

136 Conversely, only one LRP ligand, metallothionein II, was found to be chemoattractive.

137 te that both LRP1 and LRP2 are necessary for metallothionein II-mediated chemotactic signal transduct

138 Similar responses of the metallothionein IIa gene were detected in identically tr

139 Cd(2+) and Zn(2+) induced metallothionein IIa to five times higher levels than met

140 oglobulin, tissue plasminogen activator, and metallothionein III.

141 ntracellular Zn(2+)-binding proteins such as metallothionein-III (MT-III).

142 nant species at micromolar concentrations of metallothionein in cells.

143 The functional importance of metallothioneins in cadmium trafficking was highlighted

144 ke receptors 5 and 9 increase the effects of metallothioneins in MDMs.

145 omeostasis (Menkes Copper ATPase (Atp7a) and metallothionein) in the duodenal epithelium of iron-defi

146 tation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the gen

147 in-knockout and wild-type mice, indicating a metallothionein-independent zinc protection.

148 high concentrations of a species assigned to metallothionein, indicating copper dysregulation.

149 and induced expression of a gene encoding a metallothionein involved in detoxification by metal ion

150 Metallothionein is a poorly characterized, metal-binding

151 ere it is shown that the previously reported metallothionein is a prototypical member of a subfamily

152 e Zn(3)S(9) and Zn(4)S(11) clusters of human metallothionein is in a tetrathiolate coordination envir

153 f high copper exposure, Ctr1 is endocytosed, metallothionein is induced, and ATP7A moves to a more ba

154 This novel fusion between Dps and metallothionein is unique to and conserved in all Borrel

155 olecular-weight proteins like calmodulin and metallothioneins is challenging and requires modificatio

156 evidence that the transcriptional control of metallothioneins is fundamentally divergent in lower inv

157 , however, the contribution of metal-binding metallothioneins is less clear.

158 sponse that manifested in elevated levels of metallothionein isoform and zinc transporter 1 (ZnT1) tr

159 n events that have led to the development of metallothionein isoforms containing one to four alpha-do

160 onal genomics is used to explore the role of metallothionein isoforms in driving metal tolerance.

161 by the analysis of a mixture of rabbit liver metallothionein isoforms.

162 ionein null allele, as well as RNAi mediated metallothionein knock-downs.

163 y restored bacterial clearance to MDMs after metallothionein knockdown.

164 on by Zn-depletion conditions is dampened in metallothionein knockout mice, suggesting that intracell

165 ac hypertrophy and fibrosis were produced in metallothionein-knockout (MT-KO) mice fed an alcohol-con

166 Metallothionein-knockout and wild-type 129/Sv mice were

167 hepatic tumor necrosis factor-alpha in both metallothionein-knockout and wild-type mice, indicating

168 ediated signaling controls the expression of metallothioneins, known inhibitors of STAT1 phosphorylat

169 ntributed to the regulation in expression of metallothioneins, levels of zinc, autophagy, and bacteri

170 homology with IDS1 with similarity to type 2 metallothionein like protein.

171 The small Arabidopsis genome contains nine metallothionein-like (MT) sequences with classic, cystei

172 Deletion of a C-terminal metallothionein-like Cys-rich domain impacted neither nu

173 ribution in two subcellular fractions (i.e., metallothionein-like proteins and metal-rich granules).

174 l, which includes metallothioneins (MTs) and metallothionein-like proteins and peptides (MTLPs), appe

175 sporters, copper ion chaperones and putative metallothionein-like proteins were significantly more ab

176 hemokines, antiviral proteins, histones, and metallothioneins, many of which were also induced by inf

177 Collectively, our data demonstrated that metallothionein may alleviate aging-induced cardiac cont

178 Poor production of metallothionein may predispose human populations to lead

179 These data suggest that metallothionein may protect against high-fat diet-induce

180 In this body of work, two isoforms of metallothionein (MetA and MetB) isolated from trout occu

181 Metallothionein mice showed a longer life span (by appro

182 stribution of gold atoms bound to individual metallothionein molecules.

183 Aged metallothionein mouse myocytes were more resistant to th

184 n(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip1

185 Zip14 siRNA treatment also decreased metallothionein mRNA levels, suggesting that compensator

186 the relative contributions of ATP7A and the metallothioneins MT-I and MT-II to cell viability under

187 5Y cells, and the neuroprotective effects of metallothionein (MT) against salsolinol toxicity in MT o

188 genic mice that overexpress cardiac-specific metallothionein (MT) are highly resistant to diabetes-in

189 Metallothionein (MT) as a potent antioxidant prevents th

190 ce-coupled proteins transferrin, albumin, or metallothionein (MT) as well as the toxic cadmium-MT (Cd

191 It represents a new metallothionein (MT) fold with a protein chain where the

192 at single-nucleotide polymorphisms (SNPs) in metallothionein (MT) genes may underlie interindividual

193 transgenic overexpression of the antioxidant metallothionein (MT) in pancreatic beta cells provided b

194 The metal binding protein metallothionein (MT) is a target for nitric oxide (NO),

195 identification and characterization of human metallothionein (MT) isoforms in complex cell cultures u

196 Studies have shown that metallothionein (MT) may play an important role in modul

197 ia and whether the inhibition is mediated by metallothionein (MT) or is independent of MT.

198 sperm genomes contain several genes encoding metallothionein (MT) proteins that can bind metals inclu

199 Metallothionein (MT) releases zinc under oxidative stres

200 ice that overexpress the antioxidant protein metallothionein (MT) specifically in podocytes (Nmt mice

201 m zinc toxicity by inducing proteins such as metallothionein (MT) that bind it tightly, by sequesteri

202 Metallothionein (MT), a cysteine rich protein is involve

203 Metallothionein (MT), a stress-response protein, is sign

204 We report here that metallothionein (MT), an endogenous metal detoxifying pr

205 ke growth factor binding protein 1 (IGFBP1), metallothionein (MT), and cyclin D1, as well as HNF-4alp

206 ne depletion and the free radical scavenger, metallothionein (MT), on cardiac function.

207 ripheral blood, we evaluated the response of metallothionein (MT), zinc transporter, and cytokine gen

208 pe (WT) and MT-knockout (MT-KO) mice lacking metallothionein (MT)-1 and MT-2 were exposed to three at

209 Of 15,000 mouse cDNA fragments studied, metallothionein (Mt)-1 and Mt2 emerged as candidate gene

210 at was up-regulated under both conditions is metallothionein (MT)-I.

211 Administration of LPS to metallothionein (MT)-knockout (MT-KO) mice and 129/Sv wi

212 We evaluated metallothionein (MT)-mediated cardioprotection from angi

213 Previous studies using a cardiac-specific metallothionein (MT)-overexpressing transgenic mouse mod

214 phy and massive foveolar hyperplasia in both metallothionein (MT)-TGFalpha mice and patients with Men

215 ic hearts overexpressing antioxidant protein metallothionein (MT).

216 ich was induction of the antioxidant protein metallothionein (Mt).

217 g to investigate the transcriptome, we found metallothionein (MT, particularly MT-I) transcripts were

218 ted with transcriptionally silent methylated metallothionein (MT-I) promoter in the mouse lymphosarco

219 Metallothioneins (MT) are potent scavengers of free radi

220 The expression of metallothioneins (MT) has been identified as a reason fo

221 Metallothioneins (MT), induced at high levels by oxidati

222 s (UBE3C, Atrogin-1, MURF1, and PSMD11), the metallothioneins (MT1A, MT1F, MT1H), and the protease in

223 , SLC17A3, SLC12A3, and SLC30A2) and class 1 metallothioneins (MT1F, MT1G, and MT1X) in HLAi transpla

224 detoxifying and antioxidant genes, including metallothioneins MT1H, MT1M, and MT1X that have previous

225 Here, using human metallothionein (MT2) as an example, we describe an impr

226 nematode Caenorhabditis elegans has only two metallothioneins, mtl-i and mtIl-2, thus making it an id

227 Metallothioneins (MTs) and glutathione (GSH) are abundan

228 pools, whereas the MMW pool, which includes metallothioneins (MTs) and metallothionein-like proteins

229 In this context metallothioneins (MTs) appear to play a central gate-kee

230 Metallothioneins (MTs) are cytoplasmic proteins that seq

231 Metallothioneins (MTs) are low-molecular-weight, cystein

232 Metallothioneins (MTs) are small cysteine-rich proteins

233 Metallothioneins (MTs) are typically low molecular weigh

234 Metallothioneins (MTs) constitute a family of cysteine-r

235 sequestered labile Zn by inducing binding to metallothioneins (MTs) in a STAT3 and STAT5 transcriptio

236 induced protein expression of Hspa5 but not metallothioneins (MTs) in astrocytes.

237 examined the profiling of gene expression of metallothioneins (MTs) in human tissues from cadaver eye

238 Metallothioneins (MTs) in the brain and retina are belie

239 Here, we show that IL-27 induces metallothioneins (MTs) that in turn prevent Tr1 cell dev

240 es a gene that encodes the copper-protective metallothionein MymT, was highly induced in wild-type Mt

241 olution structure of Neurospora crassa Cu(6)-metallothionein (NcMT) polypeptide backbone was determin

242 scent protein (GFP) expressing transgenes, a metallothionein null allele, as well as RNAi mediated me

243 etate were tested in groups (n = 25) of male metallothionein-null and WT mice receiving drinking wate

244 Thus, the metallothionein-null mice cannot form renal inclusion bo

245 more common and more severe in lead-exposed metallothionein-null mice than in WT mice.

246 ntly observed in WT mice but did not form in metallothionein-null mice.

247 ll carcinoma also occurred in a lead-treated metallothionein-null mouse, whereas none occurred in WT

248 that metallothionein-I/-II double knockout (metallothionein-null) mice that are unable to produce th

249 The originally reported metallothionein of the American oyster, Crassostrea virg

250 This study examined the role of antioxidant metallothionein on cardiomyocyte function, superoxide ge

251 ate the impact of the free radical scavenger metallothionein on high-fat diet-induced myocardial, int

252 sociated stress kinases via the induction of metallothionein, one of the most potent antioxidant prot

253 Measures of metallothionein or cellular zinc transporters may fulfil

254 does not resemble the published spectra for metallothionein or glutathione.

255 all zinc reserve that includes zinc bound to metallothionein or zinc stored in the Golgi or in other

256 Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice a

257 tocin (STZ) (150 mg/kg) in cardiac-specific, metallothionein-overexpressing transgenic (MT-TG) mice a

258 This substantiates the notion that metallothioneins play a pivotal role in the protection f

259 We hypothesize that metallothionein plays a pivotal role in the response of

260 in, high MeHg and iHg concentrations induced metallothionein production.

261 human RET oncogene under the control of the metallothionein promoter (MT/ret mice)].

262 CBS cDNA under control of the zinc-inducible metallothionein promoter (Tg-CBS).

263 expression of Bcl-2 in transgenic mice by a metallothionein promoter caused increased LPS-induced go

264 an Arf transgene driven by a zinc-inducible metallothionein promoter, sumoylation of endogenous Mdm2

265 Ex5/+KTS) under the control of the inducible metallothionein promoter.

266 transfected with OATP2 under regulation of a metallothionein promoter.

267 o episomal vectors predictably re-programmed metallothionein-promoter-driven reporter expression.

268 haromyces cerevisiae, the genes encoding the metallothionein protein Cup1 are located in a tandem arr

269 to assign metal ion binding sites for human metallothionein protein MT-2a.

270 mpassing 19 known genes including 9 encoding metallothionein proteins.

271 At thionein/metallothionein ratios > 0.75, free Zn(II) ions are belo

272 Analysis of metallothioneins revealed that certain CvMT-I isoforms s

273 plasmin, complement components, lipocalin-2, metallothionein, serine protease inhibitor-2, transferri

274 gh levels of copper induce the expression of metallothioneins, small sulfhydryl-rich proteins with hi

275 st report of a possible single-"superdomain" metallothionein structure for Zn(2+) and Cd(2+) binding

276 nscript levels of a constitutively expressed metallothionein, suggesting increased copper chelation c

277 Metallothionein suppresses Ang II-induced NOX-dependent

278 of a small molecule chemical analogue of the metallothionein system in which an N-O reactant serves t

279 In yeast, the CUP1 gene encodes a copper metallothionein that is strongly induced in response to

280 to the sequestration of cytosolic copper by metallothioneins that are markedly up-regulated in Atp7b

281 nction module is downstream of intracellular metallothioneins that regulate zinc metabolism and can b

282 y of the chemical and enzymatic oxidation of metallothionein/thionein.

283 Because this gene encodes for metallothioneins, this result suggests that detoxificati

284 es in the levels of intracellular free zinc, metallothionein transcripts, inhibition of thioredoxin r

285 FVB and metallothionein transgenic mice were fed a high- or low-

286 ich may contribute to prolonged life span in metallothionein transgenic mice.

287 mo) FVB wild-type (WT) and cardiac-specific metallothionein transgenic mice.

288 ptible to oxidative stress, and induction of metallothionein under oxidative stress was reduced in BA

289 These studies reveal new roles for ATP7A and metallothioneins under both Cu deficiency and excess.

290 in, and analysis of Zn(II) dissociation from metallothionein using the fluorescent chelating agents F

291 NMR determination of the structure of Cd(7)-metallothionein was done previously using a relatively l

292 Metallothionein was often found associated with the oute

293 id percussion, analysis of the metal load of metallothionein was used as an indicator of changes in c

294 expression of the prioritized gene family of metallothioneins was evaluated in postmortem patient bra

295 s of the proteasome subunit (PSMD11) and the metallothioneins were increased 5 days post-SCI.

296 (2+) and Zn(2+), but not Cu(2+), induced the metallothioneins, whereas Cd(2+) and Cu(2+), but not Zn(

297 ed the expression of multiple genes encoding metallothioneins, which bind and regulate levels of intr

298 Metallothioneins with their antioxidative properties may

299 chondrial and cell signaling were negated by metallothionein, with the exception of pFoxo3a.

300 ein has been identified as a zinc-containing metallothionein (Zn-MT).