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1 d in tubular structures that derive from the metanephric mesenchyme.
2 wth and do not express GDNF in the uninduced metanephric mesenchyme.
3 ium, whereas alpha8beta1 is expressed in the metanephric mesenchyme.
4 so isolated and characterized cells from rat metanephric mesenchyme.
5 s with FGF receptors in the ureteric bud and metanephric mesenchyme.
6 of the c-ret Rtk, is not detected in Eya1-/- metanephric mesenchyme.
7 l signaling between the ureteric bud and the metanephric mesenchyme.
8 gnaling can prevent apoptosis in explants of metanephric mesenchyme.
9 initial induction of Pax-2 expression in the metanephric mesenchyme.
10  cell-cell or cell-ECM interactions with the metanephric mesenchyme.
11  the epithelium of the ureteric duct and the metanephric mesenchyme.
12 f2) is required for the specification of the metanephric mesenchyme.
13 ially modulates nephron development from the metanephric mesenchyme.
14 s the expression of both Eya1 and Wt1 in the metanephric mesenchyme.
15 o-epithelial transition in cultured isolated metanephric mesenchyme.
16 fian duct branches and invades the overlying metanephric mesenchyme.
17  activate expression of Six2 and Gdnf in the metanephric mesenchyme.
18 ngle isolated bud and its recombination with metanephric mesenchyme.
19 tage E12.5 in the murine ureteric bud and/or metanephric mesenchyme.
20 of the progenitor cell population within the metanephric mesenchyme.
21 ogether are critical for normal formation of metanephric mesenchyme.
22  the interaction of the ureteric bud and the metanephric mesenchyme.
23 anch, and the mice do not develop an obvious metanephric mesenchyme.
24 interaction between the ureteric bud and the metanephric mesenchyme.
25  and renal progenitors that are derived from metanephric mesenchyme.
26 uired for the earliest inductive response in metanephric mesenchyme.
27 ic buds, which branched independently of the metanephric mesenchyme.
28 interaction between the ureteric bud and the metanephric mesenchyme.
29 ephric duct and its derivatives, but not the metanephric mesenchyme.
30 itioning of the ureteric bud, the inducer of metanephric mesenchyme.
31 by controlling the expression of Gdnf in the metanephric mesenchyme.
32 red for the expression of these genes in the metanephric mesenchyme.
33 functions downstream of Eya1 and Six1 in the metanephric mesenchyme.
34 ced sevenfold more glomeruli than did intact metanephric mesenchyme (5 glomeruli, 127 tubules).
35 e poor contribution of rat PSCs to the mouse metanephric mesenchyme, a nephron progenitor.
36 f8 expression was reduced in early-stage DKO metanephric mesenchyme, accompanied by reduced levels of
37    It is believed that Gdnf, produced in the metanephric mesenchyme, activates Ret signaling in the W
38            Kidney epithelia develop from the metanephric mesenchyme after receiving inductive signals
39 nt and in response to inductive signals, the metanephric mesenchyme aggregates, becomes polarized, an
40 5 results in improper differentiation of the metanephric mesenchyme and absence of essential developm
41            Normally, GDNF is secreted by the metanephric mesenchyme and acts via receptors on the Wol
42              They are expressed in the early metanephric mesenchyme and are required for the inductio
43 nectin-deficient ureteric buds to invade the metanephric mesenchyme and begin branching.
44  cell line thought to originate in the early metanephric mesenchyme and glial cell line-derived neuro
45  signaling molecule GDNF is expressed in the metanephric mesenchyme and has recently been implicated
46 hat PDGFR beta localizes to undifferentiated metanephric mesenchyme and is later expressed in the cle
47 e enriched in the ureteric bud compared with metanephric mesenchyme and predicted to code for secrete
48 om two distinct embryologic populations: the metanephric mesenchyme and the ureteric bud (UB).
49 pment have considered the interaction of the metanephric mesenchyme and the ureteric bud to be the ma
50 ined its ability both to promote survival of metanephric mesenchyme and to induce nephrogenesis in cu
51 tion of two embryonically distinct analages, metanephric mesenchyme and ureteric bud.
52 ity preferentially in epithelia derived from metanephric mesenchyme, and defects in kidney architectu
53                Mice lacking Odd1 do not form metanephric mesenchyme, and do not express several other
54 posterior intermediate mesodermal cells, the metanephric mesenchyme, and induces the formation of the
55 prouty1 and WT1 overlapped in the developing metanephric mesenchyme, and Sprouty1, like WT1, plays a
56 teractions between the ureteric bud (UB) and metanephric mesenchyme are crucial for tubulogenesis dur
57 ractions between the ureteric epithelium and metanephric mesenchyme are essential for kidney morphoge
58 ions between the ureteric epithelium and the metanephric mesenchyme are needed to drive growth and di
59 dicate that Sall1-dependent signals from the metanephric mesenchyme are required to modulate ureteric
60 s between the embryonic ureteric bud and the metanephric mesenchyme are the basis for kidney developm
61 ng molecules, we developed an assay in which metanephric mesenchymes are rescued from apoptosis by fa
62 g kidney, Six1 is expressed in the uninduced metanephric mesenchyme at E10.5 and in the induced mesen
63  Eya1 expression was unaffected in Six1(-/-) metanephric mesenchyme at E10.5, indicating that Eya1 ma
64 Sall1 expression was markedly reduced in the metanephric mesenchyme at E10.5, indicating that Six1 is
65 a8 integrin-null mutants specifically in the metanephric mesenchyme at the time of ureteric bud invas
66 pm7 is essential for kidney development from metanephric mesenchyme but not ureteric bud.
67 lling is not active in the early nephrogenic metanephric mesenchyme, but instead provide expressional
68 , the ureteric bud grows out and invades the metanephric mesenchyme, but it fails to initiate branchi
69 bryos by specifically expressing Six1 in the metanephric mesenchyme, but not the ureter, under contro
70  be traced to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early s
71 cterized an explant culture system, in which metanephric mesenchyme can grow and completely different
72 ble factor(s) in the conditioned medium of a metanephric mesenchyme cell line is essential for multip
73 eiotrophin, from the conditioned medium of a metanephric mesenchyme cell line that induces isolated u
74 ctors present in the conditioned medium of a metanephric mesenchyme cell line.
75 ble factors derived from an embryonic kidney metanephric mesenchyme cell line.
76            In branching UBs induced by whole metanephric mesenchyme cell-conditioned medium, prolifer
77 8 gene is expressed together with Hoxa 11 in metanephric mesenchyme cells, and mutation of Integrin a
78 ckout of Foxd2 in ureteric bud-induced mouse metanephric mesenchyme cells.
79         Indeed, when applied to isolated rat metanephric mesenchyme, CLF-1/CLC (3 nM) induced mature
80 Osr1, Eya1, Pax2 or Wt1 gene function in the metanephric mesenchyme compromises the formation of the
81               During kidney development, the metanephric mesenchyme contributes to emerging epitheliu
82   As a result of this induction, most of the metanephric mesenchyme converts into epithelium of a nep
83                                          The metanephric mesenchyme-derived signals that control gene
84 l morphogenesis of both the ureteric bud and metanephric mesenchyme-derived structures.
85 Despite the restricted expression of Pbx1 in metanephric mesenchyme, developing nephrons, and stroma,
86                           Although, in vivo, metanephric mesenchyme development occurs simultaneously
87  In the embryonic kidney, progenitors in the metanephric mesenchyme differentiate into specialized re
88                      Furthermore, the mutant metanephric mesenchyme displayed a normal capacity to di
89                              Smad4-deficient metanephric mesenchyme does not display defects in induc
90 onship between Pax, Eya and Six genes in the metanephric mesenchyme during early kidney development i
91 al, proliferation and differentiation of the metanephric mesenchyme during kidney development.
92 In situ, the ureteric bud expressed LIF, and metanephric mesenchyme expressed its receptors.
93       Knockout of Brg1 results in failure of metanephric mesenchyme formation and depletion of nephro
94 me and proper demarcation of mesonephric and metanephric mesenchyme from the WD depends on RetY1015 s
95 nd/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are s
96                                              Metanephric mesenchyme gives rise to both the epithelial
97 vitro and in vivo, a fraction of the induced metanephric mesenchyme in Cad-6 mutant kidneys fails to
98  PSCs can efficiently differentiate into the metanephric mesenchyme in rat, allowing the generation o
99 survival factors (EGF, bFGF) and inducers of metanephric mesenchyme, including the ureteric bud, spin
100  During kidney development, factors from the metanephric mesenchyme induce the growth and repeated br
101 senchyme to differentiate into nephrons, and metanephric mesenchyme, inducing the ureteric bud to gro
102 ells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into n
103  the subsequent invasion of the bud into the metanephric mesenchyme initiate the process of metanephr
104                                 As such, the metanephric mesenchyme is a renal progenitor cell popula
105          By contrast, BMP7 expression in the metanephric mesenchyme is dependent on proteoglycans and
106   We demonstrate that Pax2 expression in the metanephric mesenchyme is independent of induction by th
107 egrin, invasion by the ureteric bud into the metanephric mesenchyme is inhibited, resulting in renal
108 cular mechanism for induction of Gdnf in the metanephric mesenchyme is not completely defined.
109 ow that both Eya1 and Six1 expression in the metanephric mesenchyme is preserved in Pax2(-/-) embryos
110                           Differentiation of metanephric mesenchyme is triggered by an inductive sign
111  between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium
112 oligonucleotides reduced condensation of the metanephric mesenchyme, leading to a decreased number of
113 he overexpression of beta-catenin within the metanephric mesenchyme leads to ectopic and disorganized
114   Second, beta-catenin overexpression in the metanephric mesenchyme leads to elevated levels of trans
115 inactivation of p53 in the UB but not in the metanephric mesenchyme lineage recapitulated the duplex
116 phric capillaries express Tie genes, whereas metanephric mesenchyme, maturing tubules, and mature pod
117               Mutual interaction between the metanephric mesenchyme (MM) and the ureteric bud (UB) in
118 sence of a conditioned medium derived from a metanephric mesenchyme (MM) cell line.
119  canonical Wnt signaling is not activated in metanephric mesenchyme (MM) during its conversion to the
120 neage tracing studies suggest that condensed metanephric mesenchyme (MM) gives rise to nephronic epit
121  disruptions led to more medially positioned metanephric mesenchyme (MM) in midgestation.
122                      The embryonic mammalian metanephric mesenchyme (MM) is a unique tissue because i
123  We find that the expression of Grem1 in the metanephric mesenchyme (MM) is Six1-dependent.
124 ssed in the ureteric bud (UB) epithelium and metanephric mesenchyme (MM) lineages.
125 owth factor receptors (Fgfrs) 1 and 2 in the metanephric mesenchyme (MM) of mice leads to a virtual a
126           Analysis of the progression of the metanephric mesenchyme (MM) through four stages of tubul
127 dneys, aberrant cell death occurs within the metanephric mesenchyme (MM), particularly in the cortica
128 s likely due to a defect in induction of the metanephric mesenchyme (MM), which along with the ureter
129 ival and maintenance of the undifferentiated metanephric mesenchyme (MM).
130 ed medium secreted by cells derived from the metanephric mesenchyme (MM).
131 s dynamically regulated in cultured isolated metanephric mesenchyme (MM).
132 sis of the ureteric bud (UB) [induced by the metanephric mesenchyme (MM)] is necessary for normal kid
133 ured UB was recombined with freshly isolated metanephric mesenchyme, nephric units were induced in th
134                 The ureteric bud invades the metanephric mesenchyme normally, but subsequent bud bran
135                                          The metanephric mesenchyme of mutant embryos lacking a urete
136                                          The metanephric mesenchyme of these mutants fails to express
137 lator has yet been identified to specify the metanephric mesenchyme or blastema within the intermedia
138 e or together with Bmp7) maintained isolated metanephric mesenchyme or sorted nephron progenitors tha
139 both DLG1 and CASK either 1) globally, 2) in metanephric mesenchyme, or 3) in nephron progenitors.
140  human embryos, OFD1a immunolocalized to the metanephric mesenchyme, oral mucosa, nasal and cranial c
141 al agenesis through a transient reduction in metanephric mesenchyme proliferation - a phenotype that
142 f metanephric fate and in the maintenance of metanephric mesenchyme proliferation and survival by act
143 n which the elevation of beta-catenin in the metanephric mesenchyme results in cell-autonomous and no
144     Co-culture of isolated ureteric buds and metanephric mesenchyme show that the primary defect is i
145 ance of Wnt-ll expression are independent of metanephric mesenchyme-specific factors.
146 ent in a conditioned medium derived from the metanephric mesenchyme that supports non-branching growt
147  clusters of epithelial progenitors from the metanephric mesenchyme, thereby separating them from the
148           Signals from the ureter induce the metanephric mesenchyme to condense and proliferate aroun
149 etween the ureteric bud epithelium, inducing metanephric mesenchyme to differentiate into nephrons, a
150 vates the expression of Six2 and Gdnf in the metanephric mesenchyme to drive nephrogenesis.
151 , mimicking the effect of BMP-7 on embryonic metanephric mesenchyme to generate epithelium.
152 for the normal nephrogenesis response of the metanephric mesenchyme to inductive signals from the ure
153 types of epithelial cells differentiate from metanephric mesenchyme to populate nephrons.
154  renal collecting system induces surrounding metanephric mesenchyme to proliferate and differentiate
155 k by antagonizing inductive signals from the metanephric mesenchyme to the illegitimate sites on the
156 angial cell precursors from undifferentiated metanephric mesenchyme to the mesangial area.
157                                              Metanephric mesenchyme was atrophic, had reduced cell re
158 owth factor receptors (fgfrs) 1 and 2 in the metanephric mesenchyme, we generated conditional knockou
159 by isolating epithelial progenitors from the metanephric mesenchyme, we show that they are targeted b
160                    When separated 13 dpc rat metanephric mesenchymes were cultured in serum-free cond
161 are thought to play an important role in the metanephric mesenchyme, when cells aggregate to form the
162 ficient to trigger tubulogenesis in isolated metanephric mesenchyme, whereas Wnt-11 which is expresse
163       In vivo, the bl/bl bud fails to invade metanephric mesenchyme which undergoes involution, event
164 ney, the epithelial ureteric bud invades the metanephric mesenchyme, which directs the ureteric bud t
165 its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to grow and different
166 Hoxa11 expression is restricted to the early metanephric mesenchyme, which induces ureteric bud forma
167 een the epithelial ureteric bud and adjacent metanephric mesenchyme, which is induced by the bud to f
168 yet to be identified) factor produced by the metanephric mesenchyme, which mediates the inductive eff

 
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