ライフサイエンスコーパス: metastasis suppressor gene

1 quely acts by transcriptionally activating a metastasis suppressor gene.

2 with a potential oncogenic function of this metastasis suppressor gene.

3 ) kinase 4 (JNKK1/MKK4) as a prostate cancer metastasis suppressor gene.

4 e, is thought to be a tumor suppressor and a metastasis suppressor gene.

5 g cascade, has been identified recently as a metastasis-suppressor gene.

6 NAi screening strategy to identify candidate metastasis suppressor genes.

7 g strategy that enables the discovery of new metastasis suppressor genes.

8 dentifying therapeutic targets downstream of metastasis suppressor genes.

9 t has been demonstrated to repress tumor and metastasis suppressor genes.

10 l facilitate the identification of candidate metastasis-suppressor genes.

11 These results indicate that RhoGDI2 is a metastasis suppressor gene, a marker of aggressive human

12 To define further the region harboring the metastasis suppressor gene, a truncated human chromosome

13 KiSS-1 has been shown to function as a tumor metastasis suppressor gene and reduce the number of meta

14 ctively, this research implicates FBXL7 as a metastasis-suppressor gene and suggests therapeutic stra

15 Metastasis-suppressor genes are attractive candidates fo

16 nctional characterization of prostate cancer metastasis-suppressor genes are discussed.

17 The mechanisms through which the metastasis suppressor gene BRMS1 functions are poorly un

18 tion and transcriptional repression of tumor metastasis suppressor gene BRMS1, highlights a new mecha

19 murine orthologue of the human breast cancer metastasis suppressor gene Brms1, suggesting that alleli

20 Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions

21 entified a novel anti-tumor activity for the metastasis suppressor gene CC3.

22 NA-methyltransferase (MGMT) and the putative metastasis suppressor gene death-associated protein kina

23 the tumor suppressor gene p16, the putative metastasis suppressor gene death-associated protein kina

24 The tumor metastasis suppressor gene Drg-1 has been shown to suppr

25 These studies implicate MKK4/SEK1 as a metastasis suppressor gene encoded by human chromosome 1

26 Erk kinase 1 (MKK4/SEK1) gene as a candidate metastasis suppressor gene encoded by the approximately

27 uggesting that there are tumor suppressor or metastasis suppressor genes encoded by this chromosomal

28 city, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome

29 KAI1 is a metastasis suppressor gene for human prostate cancer and

30 s strongly suggest that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may s

31 Previous studies demonstrated that CD44 is a metastasis suppressor gene for prostate cancer and that

32 e human chromosome 8p21-p12 region encodes a metastasis suppressor gene for rat prostate cancer.

33 uman chromosome 8p21-p12 region contains the metastasis suppressor gene for the AT6.3 cells.

34 e also tested whether chromosome 6 harbors a metastasis-suppressor gene for breast cancer as observed

35 y also indicate that chromosome 11 encodes a metastasis-suppressor gene for human breast cancer.

36 Studies of metastasis suppressor gene function are providing a crit

37 are example demonstrating the relevance of a metastasis suppressor gene function utilized in a develo

38 Here we show that the metastasis suppressor gene homolog Nm23/awd is a negativ

39 tumor suppressor genes Tbx5 and Pten and the metastasis suppressor gene Hoxd10 are significantly upre

40 ing hemizygous deletion of the Nme1 and Nme2 metastasis suppressor genes (HPN mice).

41 results show that KiSS-1 also functions as a metastasis suppressor gene in at least some human breast

42 tastasis suppressor 1 (BRMS1) functions as a metastasis suppressor gene in breast cancer and melanoma

43 ytes, suggesting that RND3 might represent a metastasis suppressor gene in HCC.

44 d site markers, and this analysis placed the metastasis suppressor gene in the interval between D8S22

45 cancer patients and suggest that there is a metastasis suppressor gene in this region that may play

46 lls, similar to the overexpression of KiSS-1 metastasis suppressor gene in those cells.

47 However, the discovery of new metastasis suppressor genes in breast cancer using genom

48 We reveal these genes to be novel metastasis suppressor genes in breast cancer.

49 Expression of nm23-H1 (NME1), a known metastasis-suppressor gene in this breast cancer cell li

50 t regulate metastasis, and the importance of metastasis-suppressor genes in this process.

51 We hypothesize that metastasis suppressor gene inactivation or down-regulati

52 Metastasis suppressor genes inhibit one or more steps re

53 l four susceptibility loci: 11q23.3 CADM1, a metastasis suppressor gene involved in modifying tumour

54 Conventional dogma has regarded E-cad as a metastasis-suppressor gene involved in epithelial-mesenc

55 This suggests that an additional metastasis suppressor gene is located within the human c

56 The loss of function of metastasis suppressor genes is a major rate-limiting ste

57 Decreased expression of the human KAI1 metastasis-suppressor gene is involved in the progressio

58 s, combined with recent studies of the tumor metastasis suppressor gene KAI1 and plasminogen activato

59 The metastasis suppressor gene KAI1 was identified by its ab

60 Metastin, the gene product of metastasis suppressor gene KiSS-1, is the endogenous lig

61 Loss of the metastasis suppressor gene, KiSS-1 has been strongly cor

62 ether the recently discovered human melanoma metastasis suppressor gene, KiSS-1, which maps to chromo

63 The metastasis suppressor gene known as Nm23-H1 regulates tu

64 state cancer, which suggests that our target metastasis suppressor gene may also play an important ro

65 Twelve metastasis suppressor genes (MSGs) have been identified

66 Although >30 metastasis suppressor genes (MSGs) that negatively regul

67 on of the cell cycle inhibitor, p21, and the metastasis suppressor gene, NDRG1 (N-myc downstream-regu

68 t revealed a novel regulatory network of two metastasis suppressor genes, NDRG1 and KAI1, which toget

69 a functional link between expression of the metastasis suppressor gene nm23 and cancer cell sensitiv

70 The expression levels of the metastasis suppressor gene Nm23 have been shown to corre

71 Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastati

72 was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2.

73 KAI1 is a metastasis suppressor gene on human chromosome 11p11.2 t

74 ocused on genetic mechanisms for the loss of metastasis suppressor genes, our results provide new evi

75 RMS1 (breast cancer metastasis suppressor 1) metastasis suppressor gene promoter via direct recruitme

76 static cancer cells to map the location of a metastasis suppressor gene(s).

77 rids, which suggests the presence of a novel metastasis-suppressor gene(s) or novel function of a kno

78 ic lineage for the identification of a novel metastasis suppressor gene, serum deprivation response (

79 The finding that DLC-1 can act as a metastasis-suppressor gene supports an influential role

80 pG island promoter methylation, invasion and metastasis suppressor genes, telomere shortening, and ge

81 ranscript (>300 kb) running antisense to the metastasis-suppressor gene TFPI-2.

82 KiSS1 is a metastasis suppressor gene that has been shown to inhibi

83 KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting

84 These findings define caspase-8 as a metastasis suppressor gene that, together with integrins

85 To discover novel metastasis suppressor genes that are clinically relevant

86 We conclude that RRM1 functions as a metastasis suppressor gene through induction of PTEN exp

87 SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby red

88 parental (C8161) metastatic cells, the KISS1 metastasis suppressor gene was isolated.

89 d symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published.

90 NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the disseminat

91 cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene whose mechanisms of action ar

92 We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is ass

93 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer pro