ライフサイエンスコーパス: metastasize

1 ncer cell transit through the vasculature to metastasize.

2 ng epithelial tumor cells to disseminate and metastasize.

3 permitting them to both form tumours and to metastasize.

4 ist environmental stress, enter dormancy, or metastasize.

5 levance: Although rare, in situ melanoma may metastasize.

6 mmon in other models of prostate cancer that metastasize.

7 r of melanocytes with a strong propensity to metastasize.

8 their precursors, with a high propensity to metastasize.

9 combined to maximize the cancer's ability to metastasize.

10 nces are maintained as the tumors invade and metastasize.

11 t converge biologically once they invade and metastasize.

12 depending on the organ to which the BC cells metastasize.

13 pes, melanoma is one with great potential to metastasize.

14 ix is critical for tumor cells to invade and metastasize.

15 'miRNA sponge' promotes the cancer cells to metastasize.

16 ive for other cells to detach and ultimately metastasize.

17 ing PDX1+ cells with an inherent capacity to metastasize.

18 ite to be colonized by neoplastic cells that metastasize.

19 er Pfn1 expression levels with propensity to metastasize.

20 uction, and a failure of cells to invade and metastasize.

21 r cells strongly suppresses their ability to metastasize.

22 worldwide, due in part to its proclivity to metastasize.

23 correlate to the ability of many cancers to metastasize.

24 otype and the propensity of these cancers to metastasize.

25 recurrences are not uncommon; a few may even metastasize.

26 st cancer in the US due to its propensity to metastasize.

27 neered sites where cancer can preferentially metastasize.

28 on is essential for understanding how tumors metastasize.

29 in part to the propensity of lung cancer to metastasize.

30 s neuroendocrine as they gain the ability to metastasize.

31 ayed an enhanced capacity to form tumors and metastasize.

32 rminant of the ability of the tumor cells to metastasize.

33 ss than 3.0 mm in LBD are highly unlikely to metastasize.

34 rognosis is less certain when primary tumors metastasize.

35 t invade through basement membranes (BMs) to metastasize.

36 rker to predict high-risk tumors before they metastasize.

37 uided systemic therapy for cancers that have metastasized.

38 melanoma demonstrated local recurrence and 1 metastasized.

39 ollow-up, and whether the lesion recurred or metastasized.

40 None of the lesions metastasized.

41 g inflammatory breast cancer that frequently metastasized.

42 primary colorectal cancer, of which half had metastasized.

43 ) is an extremely lethal cancer that rapidly metastasizes.

44 hin the tumor mass while the tumor grows and metastasizes.

45 ma, even when diagnosed early, nearly always metastasizes.

46 l cancer cells within a tumor are capable of metastasizing.

47 the epidermis and invades the dermis before metastasizing.

48 Many human glandular cancers metastasize along nerve tracts, but the mechanisms invol

49 cells (CSCs) exhibit an intrinsic ability to metastasize and acquire drug resistance through distinct

50 nt where breast cancer cells most frequently metastasize and also where FGFR is biologically active,

51 her the initial primary melanoma lesion will metastasize and cause advanced disease, but underlying m

52 al, drug sensitivity, and their potential to metastasize and cause relapse.

53 promotes the ability of melanocytic cells to metastasize and engages actin dynamics via Rho-GTPases a

54 hanges in distant organs, where cancer cells metastasize and grow.

55 The "Metastasize and Infiltrate" theory may be the key mechan

56 , the propensity for this disease to rapidly metastasize and the inability to improve patient outcome

57 The mechanisms by which tumor cells metastasize and the role of endocytic proteins in this p

58 A subset of these cases, 24 that metastasized and 24 that did not metastasize, were asses

59 ith uveal melanoma (17 patients whose tumors metastasized and 40 patients whose tumors did not metast

60 exus required for the survival and growth of metastasizing and circulating tumor cells in vivo.

61 Boundaries of metastasizing and non-metastasizing primary tumors were

62 our screening study comparing mRNA levels in metastasizing and nonmetastasizing endometrial carcinoma

63 tasized and 40 patients whose tumors did not metastasize), and 37 healthy donors.

64 or ablation, a subset of these tumors recur, metastasize, and cause death.

65 Due to its high proclivity to metastasize, and despite the recent development of targe

66 ected independent tumor lineage that did not metastasize, and early progenitor clones with the "first

67 fferentiated disease into a more aggressive, metastasizing, and fatal malignancy.

68 When cancer cells metastasize, angiogenesis is also required for metastati

69 ry thyroid carcinomas that invade locally or metastasize are associated with a poor prognosis.

70 ear when in tumor progression the ability to metastasize arises and whether this ability is inherent

71 tually extravasate across the endothelium to metastasize at a secondary site.

72 oma is characterized by a high propensity to metastasize at low tumor volumes necessitating the need

73 arose several millennia ago and survives by "metastasizing" between hosts through cell transfer.

74 ading, dynamic loads applied to the knee, on metastasized bone and mammary tumors.

75 ells, while BMD cells were isolated from the metastasized bone.

76 We hypothesized that, to metastasize, breast cancers may escape their normative g

77 Lung cancer is notorious for its ability to metastasize, but the pathways regulating lung cancer met

78 e mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remai

79 Pancreatic ductal adenocarcinoma (PDAC) metastasizes by neural, vascular, and local invasion rou

80 , 19 patients were alive, but their melanoma metastasized, by the end of the observation period (mean

81 5; confirmatory cohort: n=44) suffering from metastasized cancer were analyzed applying the American

82 tially developed as a theranostic ligand for metastasized cancer, FAPI (FAP inhibitor) tracers have r

83 uld not only increase genomic instability in metastasizing cancer cells but could also cause DNA dama

84 onmental cues in the regulation of miRNAs in metastasizing cancer cells has not been studied.

85 ese results suggest that host B7x may enable metastasizing cancer cells to escape local antitumor imm

86 The reduction in miR-193b enabled the metastasizing cancer cells to invade and proliferate int

87 ick, adaptable switch to promote survival of metastasizing cancer cells.

88 and even less is known about the identity of metastasizing cancer cells.

89 potential therapeutic target for lung-tropic metastasizing cancers.

90 excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC

91 thods: One hundred consecutive patients with metastasized castration-resistant prostate cancer schedu

92 prostate-specific membrane antigen (PSMA) in metastasized castration-resistant prostate cancer.

93 Collectively, this study demonstrates that metastasized cells are less migratory due in part to the

94 ived pancreatic cancer samples indicate that metastasized cells present significantly lower heterogen

95 onfer differences in metastatic potential as metastasizing cells depend on MCT1 to manage oxidative s

96 After separating from a primary tumor, metastasizing cells enter the circulatory system and int

97 but to later become a metabolic liability in metastasizing cells that is counteracted by decreased TI

98 salivary gland cancers frequently recur and metastasize despite definitive treatment, with no known

99 to judge the prognosis of patients harboring metastasized differentiated thyroid cancer (DTC); identi

100 etastasizing monosomy 3 uveal melanoma; iii) metastasizing disomy 3 uveal melanoma; and iv) monosomy

101 eatment, and redifferentiation treatment for metastasized DTC.

102 servation (mean 0.32 cm/year), but only 1.4% metastasized during 32 months of follow-up (median).

103 ng cells admixed with MSCs/CAFs grew faster, metastasized earlier, especially to lungs, and were extr

104 play a dominant role by invading further and metastasizing earlier.

105 ells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting

106 The capacity for tumor cells to metastasize efficiently is directly linked to their abil

107 Y537S ESR1 mutant primary tumors metastasized efficiently in the absence of E(2); however

108 ring epithelial-to-mesenchymal transition of metastasizing epithelial tumors, we generated citrullina

109 ficient tumours both invade collectively and metastasize equally, implicating additional mechanisms c

110 However, tumor cells grew and metastasized equally well in Fbln2-null and -wild-type l

111 f g-E and g-EAR delayed bioluminescence from metastasizing ES-2-luc cells for 2 and 3weeks, respectiv

112 K-Ras-driven tumors can grow and metastasize even in the absence of the oxidative pentose

113 ient renal cancers are highly aggressive and metastasize even when small, leading to a very poor clin

114 Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the

115 Cancer can metastasize from early lesions without detectable tumors

116 In general, they are slow growing and do not metastasize; however, locally aggressive desmoid tumors

117 Our findings imply that the ability to metastasize-i.e., to colonize distant sites-is the direc

118 t1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice.

119 arcinoma cells and analyzed their ability to metastasize in 2 independent mouse models.

120 ls is necessary to maintain their ability to metastasize in a chick embryo model.

121 human prostate cancer gene expression, which metastasize in immune-competent mice, are a valuable new

122 In contrast, these cells readily grow and metastasize in immuno-deficient athymic or Rag2(-/-) mic

123 breast cancer cells, which form tumors that metastasize in immunocompetent mice.

124 and is characterized by its high tendency to metastasize in lungs.

125 stories in patients and in their capacity to metastasize in NOD-SCID-Il2rg(-/-) (NSG) mice.

126 n-2 was required for tumor cells to grow and metastasize in syngeneic mice, a surprising finding give

127 nce of carcinomas that either did or did not metastasize in the same host animal suggests that there

128 ly, tumor cells that acquired the ability to metastasize in vivo constitutively downregulated SNPH an

129 cause of detachment (anoikis resistance) and metastasize in vivo To examine the mechanism by which CP

130 Rac3 regulates the ability of tumor cells to metastasize in vivo.

131 eases the ability of CRC cells to invade and metastasize in vivo.

132 how decreased ability to invade in vitro and metastasize in vivo.

133 The prostate cancer cell lines metastasized in FVB mice to brain and bone.

134 Of these 83 patients, 21 had melanoma that metastasized in the studied nodal basin for an in-basin

135 ancers, it inhibits primary lung tumors from metastasizing in a mouse model system.

136 tatic lesions to the oral mucosa; only cases metastasizing in the oral mucosa, gingiva, and periodont

137 Group 2 (n = 19; 42% metastasized, including 5 G1 tumors) was characterized b

138 The tumors metastasize inducibly and robustly to the liver.

139 cancer cells escape immune surveillance and metastasize into bone tissue by inducing osteoclastic bo

140 ggressive form of skin cancer, which further metastasizes into a deadly form of cancer.

141 brane of the surface epithelium, invade, and metastasize is essential to the development of novel tre

142 is typically diagnosed after the disease has metastasized; it is among the most lethal forms of cance

143 Benign metastasizing leiomyoma (BML) is a rare condition descri

144 ction with the diagnosis of pulmonary benign metastasizing leiomyoma being stated.

145 We present a case of pulmonary benign metastasizing leiomyoma in a female patient admitted to

146 Pulmonary benign metastasizing leiomyoma is a rare entity.

147 es confirmed the initial diagnosis of benign metastasizing leiomyoma with no evidence of neoplastic c

148 The tumors metastasize loco-regionally and are accompanied by high

149 However, in the B16-F10-metastasized lungs, ICOS-Fc also increased IL-17A/RORc a

150 ty-six adults with histologically documented metastasized malignant melanoma received a single dose o

151 L-deficient (lal(-/-)) mouse model, melanoma metastasized massively in allogeneic lal(-/-) mice, whic

152 l targets for the diagnosis and treatment of metastasizing MB in humans.

153 Successfully metastasizing melanomas underwent reversible metabolic c

154 ndling between efficiently and inefficiently metastasizing melanomas, with circulating lactate being

155 plantation, particularly among inefficiently metastasizing melanomas.

156 subcutaneous H1975/AZDR model and the brain metastasized model demonstrated the effectiveness of the

157 uveal melanoma with long-term survival; ii) metastasizing monosomy 3 uveal melanoma; iii) metastasiz

158 tion of blood vessels and lymph vessels, and metastasized much less effectively to lymph nodes.

159 ioleiomyomatosis (LAM) is a rare, low-grade, metastasizing neoplasm that arises from an unknown sourc

160 the view of LAM as a low-grade, destructive, metastasizing neoplasm.

161 y as those caused by low-grade or high-grade metastasizing neoplasms, polyclonal or monoclonal lympho

162 onsidered a safe treatment for patients with metastasized neuroendocrine tumors and prostate cancer,

163 r cells possess the ability to, for example, metastasize or to tolerate cytotoxic drugs.

164 hat in MM, CTCs may egress to PB to colonize/metastasize other sites in the BM during the patients' r

165 stic scintigraphy and SPECT of patients with metastasized ovarian and pancreatic cancer for follow-up

166 lymph nodes revealed the presence of grossly metastasized ovarian cancer cells within the lymphoid ti

167 on of a tumor suppressor miRNA, miR-193b, in metastasizing OvCa cells.

168 performed for 24 lesions in 24 patients with metastasized pancreatic neuroendocrine tumors treated wi

169 Methods: Eight patients with metastasized PCa were included.

170 Here, we show that tumor cells that metastasize predominantly to the lung, such as renal cel

171 t presentation, up to 25% of gastrinomas are metastasized, predominantly to the liver.

172 Boundaries of metastasizing and non-metastasizing primary tumors were readily defined, leadi

173 lp physicians quantify tumor load in heavily metastasized prostate cancer patients.

174 patients (mean age +/- SD, 64 +/- 8 y) with metastasized prostate cancer underwent two sets of (18)F

175 (PSMA) are under development for therapy of metastasized prostate cancer.

176 , from 8 patients with histologically proven metastasized prostate cancer.

177 ubal Intraepithelial Carcinoma (STIC), which metastasized rapidly to the ovarian surface.

178 Melanoma is an aggressive cancer that metastasizes rapidly and is refractory to conventional c

179 ancy that invades surrounding structures and metastasizes rapidly.

180 ten lethal because it is highly invasive and metastasizes rapidly.

181 carcinoma (MCC) is a lethal skin cancer that metastasizes rapidly.

182 ancer cells, including melanoma cells, often metastasize regionally through the lymphatic system befo

183 cer, but the mechanisms by which tumor cells metastasize remain incompletely understood.

184 ors exploit unique biophysical properties to metastasize remains unclear.

185 1)In-cG250 or (177)Lu-cG250 in patients with metastasized renal cell carcinoma were analyzed quantita

186 ipulating genetic and non-genetic factors to metastasize, resist treatment, and maintain the tumor mi

187 se 14 patients, 11 had primary IOL and 3 had metastasized secondary lymphomas.

188 Prostate cancer (PCa) metastasizes selectively to bone through unknown mechani

189 planted in liver, where colon tumors usually metastasize, SFV-IL-12 efficacy was significantly reduce

190 nesis in vivo remains poor, in particular in metastasizing solid cancers.

191 In the metastasizing state, the course of the disease is often

192 Higher levels of LRV-1 in metastasizing strains of L.V. guyanensis have been docum

193 enges in the host tissue microenvironment to metastasize successfully to distant organs.

194 tissues at which breast cancer cells tend to metastasize such as the lungs and the brain.

195 Only a tiny proportion successfully metastasize, supporting the notion of metastasis-specifi

196 gionally through the lymphatic system before metastasizing systemically through the blood(1-4); howev

197 Cancer cells metastasize through the bloodstream either as single mig

198 Cells that metastasized through blood, but not those that metastasi

199 tastasized through blood, but not those that metastasized through lymph, became dependent on the ferr

200 ggressive type of skin cancer, which readily metastasizes through lymph nodes to the lungs, liver, an

201 ad to engulf the ovary and then aggressively metastasize throughout the abdominal cavity, causing asc

202 Solid tumors frequently metastasize to bone and induce bone destruction leading

203 Patients with tumors that metastasize to bone frequently suffer from debilitating

204 omotes survival of prostate TIC and CTC that metastasize to bone, whereas HER2 supports the growth of

205 tant talin1(S425D) restored their ability to metastasize to bone.

206 We found that SOX11+DCIS tumour cells metastasize to brain and bone at greater frequency and t

207 nificantly suppressed the ability of CSCs to metastasize to brain but not to bone in our animal model

208 Tumor cells metastasize to distant organs through genetic and epigen

209 the ability to invade basement membranes and metastasize to distant sites, establishing it as an appe

210 nsition (EMT) is co-opted by cancer cells to metastasize to distant sites.

211 oenvironments to survive in the circulation, metastasize to ectopic sites, and escape therapeutic int

212 neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node

213 n receptor (AR)-positive ccRCC may prefer to metastasize to lung rather than to lymph nodes.

214 s of increasingly aggressive cell lines that metastasize to lung.

215 rt inhibitor brefeldin A (BFA) in cells that metastasize to lung.

216 resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes.

217 tumor cells migrate toward blood vessels and metastasize to lymph nodes.

218 led that these cells had a high potential to metastasize to sites such as the liver.

219 r predicts the potential of breast cancer to metastasize to soft tissues.

220 nical observations suggest that most cancers metastasize to specific organs, a process known as "orga

221 directional cues for breast cancer cells to metastasize to specific organs.

222 nsplanted onto the colonic mucosa invade and metastasize to specific target organs including the inte

223 g of primary cancer with a known tendency to metastasize to the bone marrow.

224 r is among the most common malignancies that metastasize to the brain, with 15% to 20% of patients wi

225 ly suppressed the ability of cancer cells to metastasize to the brain.

226 About 30% of breast cancers metastasize to the brain; those widely disseminated are

227 lp elucidate mechanisms by which tumor cells metastasize to the central nervous system.

228 RC organoids engraft in the distal colon and metastasize to the liver.

229 ypically indolent; however, a limited subset metastasize to the liver.

230 mary tumors of colorectal cancer (CRC) often metastasize to the liver.

231 Because the majority of solid tumors metastasize to the lung, we developed a multicellular lu

232 t proteins to enable the two cancer types to metastasize to the lung.

233 es against osteosarcoma cell lines, known to metastasize to the lungs (CCH-OS-O and SJSA), similar to

234 ncer cells to form colonies in soft agar and metastasize to the lungs or liver.

235 on malignant bone tumor with a propensity to metastasize to the lungs.

236 ignant melanoma has an unusual propensity to metastasize to the small bowel; however, malignant melan

237 vaded sentinel lymph nodes and significantly metastasized to lungs compared to control tumors.

238 , prostate tumor tissues and prostate cancer metastasized to lungs showed a higher expression of Pak1

239 2-month-old mice were highly aggressive, and metastasized to nearby and distant organs within the per

240 med tumors, and in one case, SKNBE(2)C iCSCs metastasized to the adrenal gland, suggesting their incr

241 tools, and available treatments for melanoma metastasized to the intestines.

242 pancreatic and colorectal cancers that have metastasized to the liver, and many patients with locall

243 titis tissues and in pancreatic cancer cells metastasized to the liver.

244 te significantly reduced the number of cells metastasized to the lung without affecting the growth in

245 2 in a subset of primary human sarcomas that metastasized to the lungs.

246 s markedly overexpressed in some tumors that metastasized to the lungs.

247 Advanced-stage prostate cancer usually metastasizes to bone and is untreatable due to poor biod

248 Human prostate cancer often metastasizes to bone, but the biological basis for such

249 Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells acr

250 arly detected cancers is high, once a cancer metastasizes to bone, it is incurable.

251 iculty of sampling as prostate cancer mainly metastasizes to bone.

252 a serious health problem that preferentially metastasizes to bone.

253 gnant tumor that often invades the brain and metastasizes to distal organs through the blood stream.

254 Pancreatic ductal adenocarcinoma (PDAC) metastasizes to distant organs, which is the primary cau

255 ntratumoral heterogeneity as medulloblastoma metastasizes to leptomeninges and as it evolves in the f

256 Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disea

257 Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as

258 e major reason for this is that PDAC quickly metastasizes to other organs, thereby making its treatme

259 It commonly metastasizes to the bone marrow.

260 Prostate cancer (PC) commonly metastasizes to the bone, resulting in pathologic fractu

261 Melanoma frequently metastasizes to the brain, resulting in dismal survival.

262 Colorectal cancer primarily metastasizes to the liver and globally kills over 600,00

263 provide insights into how colorectal cancer metastasizes to the liver, the most common site of disse

264 Ovarian cancer selective metastasizes to the omentum contributing to the poor pro

265 Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterize

266 The lowest T category tumor metastasizing to both regional nodes and distant locatio

267 fest distinct gene expression patterns after metastasizing to different organs.

268 was inhibited, and the number of tumor cells metastasizing to lung was reduced significantly by combi

269 c lesions to the gingiva compared with cases metastasizing to other oral mucosal sites.

270 Breast cancers capable of metastasizing to the brain showed evidence of altered li

271 molecular basis of breast cancers capable of metastasizing to the brain-a principal cause of death in

272 the Fallopian tube's epithelium (TE) before metastasizing to the ovary.

273 ngiogenesis, which may influence the fate of metastasized tumor cells, was also COX-2/EP3-dependent.

274 cinoma transformation and expressed later in metastasized tumor cells.

275 Importantly, the omentum collects metastasizing tumor cells and supports tumor growth by i

276 Reduced recruitment of monocytes to metastasizing tumor cells in Fuc-TVII(-/-) mice correlat

277 Thus, the recruitment of monocytes to metastasizing tumor cells is facilitated by endogenous s

278 Metastasizing tumor cells migrate through the surroundin

279 rise from a multi-step process that requires metastasizing tumor cells to adapt to signaling input fr

280 , may enable a molecular mimicry that allows metastasizing tumor cells to downregulate MHC class I, t

281 As metastasizing tumor cells undergo epithelial to mesenchy

282 The recruitment of inflammatory monocytes to metastasizing tumor cells was dependent on the local end

283 s critically dependent on the interaction of metastasizing tumor cells with cells in the local microe

284 PMo established early interactions with metastasizing tumor cells, scavenged tumor material from

285 ns regulates migratory and invasive nexus of metastasizing tumor cells.

286 n vivo cancer cell tracking in spontaneously metastasizing tumor models still poses a challenge requi

287 To metastasize, tumor cells often need to migrate through a

288 emerging strategies for targeted imaging of metastasized tumors and metastasis-directed delivery of

289 Late detection of then nonresectable or metastasized tumors emphasizes the need for novel imagin

290 istinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96%

291 emalignant lesions and lower TIGAR levels in metastasizing tumors.

292 anoma is a highly aggressive tumour that can metastasize very early in disease progression.

293 ors enhanced LEC recruitment, the ability to metastasize was dependent on the expression of VEGFD.

294 However, the capacity to metastasize was not modified.

295 Group 1 (n = 15; 73% metastasized) was characterized by recurrent chromosomal

296 Group 3 (n = 14; 35% metastasized) were defined by chromosome 11 loss.

297 es, 24 that metastasized and 24 that did not metastasize, were assessed by targeted next-generation s

298 tment with Ccl2 and Il13 induced MYC-HCCs to metastasize; whereas, blockade of Ccl2 and Il13 abrogate

299 SCLC) is extremely aggressive and frequently metastasizes widely in its early stage.

300 tumour cells' ability to migrate, invade and metastasize without affecting the cell survival and grow