ライフサイエンスコーパス: metastatic potential

1 GIT or anti-KLRG1 antibodies further reduced metastatic potential.

2 omic instability and aggressive disease with metastatic potential.

3 lls profoundly inhibited their migratory and metastatic potential.

4 sis we show that knockdown of Kdm3a enhances metastatic potential.

5 av1 in HCC cells enhances their invasive and metastatic potential.

6 tumors with shorter latency and have higher metastatic potential.

7 n a tumor could act as a physical marker for metastatic potential.

8 nal consequences on tumor cell signaling and metastatic potential.

9 gression from benign to invasive stages with metastatic potential.

10 elerated mammary tumorigenesis with enhanced metastatic potential.

11 s quantified by a key parameter of intrinsic metastatic potential.

12 -tissue sarcomas and is associated with high metastatic potential.

13 oor prognosis due to its highly invasive and metastatic potential.

14 (MCC), an aggressive skin cancer with a high metastatic potential.

15 ells with increased stem cell properties and metastatic potential.

16 conventional anticancer treatments and high metastatic potential.

17 through multiple passages, and tumors retain metastatic potential.

18 tion and invasion in cancer cells to promote metastatic potential.

19 the most prevalent invasive malignancy with metastatic potential.

20 n with ERK clones were employed to determine metastatic potential.

21 a major biological correlate of breast tumor metastatic potential.

22 tumor growth, apoptotic resistance and high metastatic potential.

23 lines induced AnR and dramatically increased metastatic potential.

24 ntributing to acquisition and maintenance of metastatic potential.

25 where its expression correlated with reduced metastatic potential.

26 from the immune system, and facilitate their metastatic potential.

27 t, histological appearance, invasiveness and metastatic potential.

28 development or abnormal cells as they evolve metastatic potential.

29 in terms of predictability, complexity, and metastatic potential.

30 histopathology, cytogenetic complexity, and metastatic potential.

31 , CTC clusters have 23- to 50-fold increased metastatic potential.

32 portant biomarkers of cancer progression and metastatic potential.

33 ial depletion of Dicer, can promote enhanced metastatic potential.

34 as possible markers for disease relapse and metastatic potential.

35 witch that confers cancer cells an increased metastatic potential.

36 ells with stem-cell-like properties and high metastatic potential.

37 fer aberrant proliferative, survival, and/or metastatic potential.

38 kers or differentiation is the best guide to metastatic potential.

39 ungs of nude mice, suggesting an increase in metastatic potential.

40 ssor whose loss is associated with increased metastatic potential.

41 ns may dysregulate miRNAs, in turn affecting metastatic potential.

42 ndependent growth in soft agar, and enhanced metastatic potential.

43 he adrenal gland, suggesting their increased metastatic potential.

44 on compounds in general) with intrinsic anti-metastatic potential.

45 erivative of MCF10a cells selected for their metastatic potential.

46 n vimentin is observed, indicating increased metastatic potential.

47 r samples and its expression correlated with metastatic potential.

48 in adhesivity, which can be used to predict metastatic potential.

49 aster entry velocities than cells with lower metastatic potential.

50 as a potential factor that influences brain metastatic potential.

51 n be mechanistically coupled to greater bone metastatic potential.

52 s, a property that correlates with increased metastatic potential.

53 ers and suggested to serve as a barometer of metastatic potential.

54 ligand (FasL) and show high malignancy with metastatic potential.

55 susceptibility to anoikis and impairs their metastatic potential.

56 significant effect on both tumor growth and metastatic potential.

57 rade tumors from high-grade tumors with high metastatic potential.

58 wth, it had a dramatic effect on spontaneous metastatic potential.

59 ansport barriers, and the tumor invasive and metastatic potential.

60 y enhance chemotaxis to HRGbeta1 and overall metastatic potential.

61 STAT1 in STS cells, thereby increasing their metastatic potential.

62 smaller tumors that exhibited an attenuated metastatic potential.

63 aling, neovascularization, invasiveness, and metastatic potential.

64 is process is critical to the acquisition of metastatic potential.

65 r the TME in mitochondrial heterogeneity and metastatic potential.

66 the ECM influences melanoma cells of varying metastatic potential.

67 rofiles in CTCs from patients with differing metastatic potential.

68 ity characteristics relative to cells of low metastatic potential.

69 d associated with increased invasiveness and metastatic potential.

70 and mesenchymal states contributes to their metastatic potential.

71 n these mice by histology for cell types and metastatic potential.

72 nced cancer cell survival, proliferation and metastatic potential.

73 tiation, transformation, tumorigenicity, and metastatic potential.

74 tumor might serve as a prognostic marker for metastatic potential.

75 mechanism whereby cancer stem cells acquire metastatic potential.

76 alter their antioxidant capacity for maximal metastatic potential.

77 endow rare cells within a primary tumor with metastatic potential.

78 form secondary tumors, and possess increased metastatic potential.

79 AC cells and Suit2 derivatives with enhanced metastatic potential.

80 umour adaptation, therapeutic resistance and metastatic potential.

81 hyme (EMT) transition and possible increased metastatic potential.

82 A shape its genetic landscape and define its metastatic potential.

83 hich has low endogenous ST6Gal-I and limited metastatic potential, along with two metastatic Suit2-de

84 p63 led to both rapid tumour development and metastatic potential, although the incidence of metastas

85 tant lung adenocarcinoma cell line with high metastatic potential and an orthotopic syngeneic mouse m

86 he most frequently occuring skin cancer with metastatic potential and can manifest rapidly as a commo

87 ction in tumors is associated with increased metastatic potential and cell seeding, poor prognosis, a

88 nt neoplasm of melanocytes with considerable metastatic potential and drug resistance, explaining the

89 cells and is often associated with increased metastatic potential and drug resistance.

90 each one comprising a parental line with low metastatic potential and its experimentally selected, hi

91 ntiation status of tumors is correlated with metastatic potential and malignancy.

92 nt models to assess the impact of surgery on metastatic potential and may guide optimal timing of tre

93 pression and transcriptional activities with metastatic potential and poor prognosis in cancer, altho

94 pressure has been associated with increased metastatic potential and poor prognosis in some tumors.

95 sine kinase ErbB-2 are characterized by high metastatic potential and poor prognosis, but the signali

96 2) expression, is associated with heightened metastatic potential and poor prognosis.

97 on of Phip in melanoma cell lines suppressed metastatic potential and prolonged the survival of tumor

98 proliferation rate, cell-cell interactions, metastatic potential and sensitivity to therapy.

99 Cancer cells with high metastatic potential and stem cell-like characteristics

100 t when activated in cancer endows cells with metastatic potential and the properties of stem cells.

101 er Notch signaling correlates with increased metastatic potential and worse disease survival rates.

102 ategorizes melanoma specimens based on their metastatic potential and, importantly, is capable of str

103 espect to their infiltrative growth pattern, metastatic potential, and altered cell differentiation b

104 proliferation, anchorage independent growth, metastatic potential, and enhance apoptosis.

105 ors positively correlate with cell motility, metastatic potential, and grade, including bladder, mela

106 .Ecad exhibits delayed tumor growth, reduced metastatic potential, and increased overall survival in

107 human cancers, enhancing their invasiveness, metastatic potential, and poor prognosis.

108 e relationship between growth, migration and metastatic potential, and provides a new tool for profil

109 rcinomas (SCC) is characterized by increased metastatic potential, and SCC progression is associated

110 nes resulting in increased tumor initiation, metastatic potential, and therapeutic resistance.

111 and MCF-7) with distinct deformabilities and metastatic potentials, and (ii) a heterogeneous breast c

112 Cells with metastatic potential are often characterized by altered

113 motherapy and the acquisition of invasive or metastatic potential, arose within detectable subclones

114 s among melanoma cells confer differences in metastatic potential as a result of differences in the f

115 mong cancer cells thus confer differences in metastatic potential as metastasizing cells depend on MC

116 ations might have gained growth advantage or metastatic potential, as a result of viral integration e

117 evidence in line with autopsy data that the metastatic potential, as shown by the incidence of CUP,

118 novel integrated perspective on the enhanced metastatic potential associated with MUC16 overexpressio

119 sion related to mitochondrial activities and metastatic potential at the tumor-stromal interface.

120 of E-cadherin is an important determinant of metastatic potential beyond whether the gene is expresse

121 to a group of benign fibrous growths without metastatic potential but with a significant risk of loca

122 only a surface marker for cells with higher metastatic potential, but also functionally involved in

123 er stem cells (CSC) appear to have increased metastatic potential, but mechanisms underlying this are

124 trol of cytoplasmic and extracellular pH and metastatic potential, but the isoforms involved and the

125 ased proliferation, decreased apoptosis, and metastatic potential by conservation of proteins like ep

126 We demonstrate that miR-22 exerts its metastatic potential by silencing antimetastatic miR-200

127 atrix such as fibronectin and compared their metastatic potentials by measuring the rupture force of

128 To test the metastatic potential conferred by increased Dyn2 express

129 Melanoma cells of high metastatic potential demonstrate increased growth and ve

130 ts and show that primary tumors of differing metastatic potential differ in ECM composition.

131 elopment of specific inhibitors for reducing metastatic potential during radiotherapy.

132 d with longer glycopolymers showed increased metastatic potential, enhanced cell cycle progression, a

133 t mass, we find that cells possessing higher metastatic potential exhibit faster entry velocities tha

134 onally find that some cell types with higher metastatic potential exhibit greater than expected chang

135 teosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modif

136 n of the genetic interactions that influence metastatic potential has been challenging.

137 but aggressive cutaneous neoplasm with high metastatic potential, has a poor prognosis at late stage

138 correlated with poor prognosis and increased metastatic potential in a number of cancers.

139 n in vitro and significantly reduced in vivo metastatic potential in a preclinical model of experimen

140 fter arterial injury and markedly diminished metastatic potential in a setting of experimental tumor

141 D49f(-) cells in tissue culture and enhanced metastatic potential in allograft-nude mice.

142 ubulin acetylation are a sufficient cause of metastatic potential in breast cancer.

143 eby enhances the invasive, proliferative and metastatic potential in cancer.

144 s have highlighted the implications of their metastatic potential in cancers.

145 ti-cellular aggregates (MCAs), of increasing metastatic potential in different elastic moduli of hydr

146 nd CD44 contribute to early pathogenesis and metastatic potential in established lung cancer.

147 egulate mammary carcinoma tumorigenicity and metastatic potential in genetic crosses.

148 apeutic resistance also correlates with high metastatic potential in human cancers, including breast

149 reased tumor growth, tumor angiogenesis, and metastatic potential in many malignancies, including pan

150 ong correlation between NFAT1 expression and metastatic potential in melanoma cell lines and tumor sp

151 rovide a major source of Wnt5A to facilitate metastatic potential in melanoma cells and rely on Wnt5A

152 we grafted human RCC cells with varying lung metastatic potential in mice.

153 ibited carcinoma cell migration in vitro and metastatic potential in mice.

154 3b/27b/24 cluster is found to correlate with metastatic potential in mouse and human breast cancer ce

155 d in vivo as tumorigenicity and experimental metastatic potential in NOD/SCID mice.

156 cell invasion and increases tumor growth and metastatic potential in nude mice.

157 h the markers Sca1 and CD24 are enriched for metastatic potential in orthotopic transplantation assay

158 ial for identifying cell subpopulations with metastatic potential in primary tumors or with resistanc

159 mbrane (PM) are correlated with the enhanced metastatic potential in these cell lines.

160 ling, reverses EMT and reduces breast cancer metastatic potential in vitro and in vivo.

161 sphere-forming ability, metabolic shift and metastatic potential in vitro and in vivo.

162 hymal transition with highly tumorigenic and metastatic potential in vivo compared to conventional tw

163 acity during reoxygenation in vitro and lung metastatic potential in vivo On a mechanistic level, we

164 ack PTPN12 exhibited reduced tumorigenic and metastatic potential in vivo that correlated with their

165 dulating Cnot2 expression changes tumor cell metastatic potential in vivo, supporting a functional ro

166 on in breast cancer cells that has increased metastatic potential in vivo.

167 dance of cancer cells with tumor-forming and metastatic potential in vivo.

168 altering tumor growth, chemosensitivity and metastatic potential in vivo.

169 endometrial cancer cells in vitro and their metastatic potential in vivo.

170 nges, and fully restored melanoma growth and metastatic potential in vivo.

171 asive properties of the cells, and decreased metastatic potential in vivo.

172 on (based on an in vitro assessment of their metastatic potential) in PANC-1, a PDAC cell line.

173 The effect of miR-200b on metastatic potential involved the expression regulation

174 The PSA-mediated enhancement of metastatic potential involved the induction of HDAC3, MC

175 The increased metastatic potential is dependent on IL-6 induction medi

176 The impact of such diversification on metastatic potential is unknown.

177 nd the induction of apoptosis; (b) decreased metastatic potential mediated by down-regulation of the

178 ificantly rescued the decreased invasive and metastatic potential mediated by RSK2 knockdown in vitro

179 o report that the oncogene RhoC, a driver of metastatic potential, modulates glutamine and N-acetylas

180 e tumor control for iris melanoma with a low metastatic potential of 1% at 7 years.

181 of its activity is associated with increased metastatic potential of A549 cells.

182 Finally, we found that the metastatic potential of breast cancer and melanoma cells

183 tastasis, the device accurately predicts the metastatic potential of breast cancer cell lines and of

184 DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repr

185 signatures, and their depletion impairs the metastatic potential of breast cancer cells.

186 eta-regulated "metastamir" that enhanced the metastatic potential of breast cancers by promoting epit

187 rve as a new biophysical marker to probe the metastatic potential of cancer cells and even to monitor

188 re, the applicability for discriminating the metastatic potential of cancer cells by directly analyzi

189 -MEA effectively attenuated the invasive and metastatic potential of cancer cells in vitro and in viv

190 in stem cell pluripotency and suppresses the metastatic potential of cancer cells through multiple me

191 The finding that folate modulates metastatic potential of cancer cells was confirmed in an

192 had negative effects on the tumorigenic and metastatic potential of cancer cells.

193 nosuppression, and enhances the invasive and metastatic potential of cancer cells.

194 en implicated in increased cell invasion and metastatic potential of cancer cells.

195 ical to be able to assess quantitatively the metastatic potential of cancer cells.

196 In this study, we have investigated metastatic potential of cancer stem cells (CSCs) isolate

197 t classifier that can accurately predict the metastatic potential of cells at a single-cell level.

198 ted with functional cross-talk and increased metastatic potential of cells.

199 ular mechanism of radioresistance-associated metastatic potential of cervical cancer cells.

200 ession of NFATc1 significantly increased the metastatic potential of colon cancer cells, whereas inhi

201 roRNA (miR)-192 is inversely correlated with metastatic potential of colon cancer cells.

202 nhanced intracellular oxygen contents on the metastatic potential of colon cancer.

203 mportance of clonal variation in determining metastatic potential of colorectal cancer cells using th

204 Tumorigenicity and metastatic potential of colorectal tumor cells over and

205 g to a collagen scaffold, suggesting an anti-metastatic potential of CUR.

206 present study, we aimed to evaluate the anti-metastatic potential of deguelin in vivo and in tumor gr

207 y been linked to cellular transformation and metastatic potential of epithelial cancers, our findings

208 ctopaxin expression also correlated with the metastatic potential of HCC cell lines.

209 rin-A3 and novel EFNA3 lncRNAs increased the metastatic potential of human breast cancer cells, possi

210 strategy that is capable of determining the metastatic potential of human cancer cell lines in mouse

211 sublethal dose of radiation can enhance the metastatic potential of human cervical cancer cells via

212 iR221) has also been reported to enhance the metastatic potential of human TNBC, but miR221's relatio

213 on in tumors markedly reduces the number and metastatic potential of infiltrating tumor-associated ma

214 significantly abrogated the tumorigenic and metastatic potential of invasive breast cancer cells.

215 Further, knockdown of ERK3 reduces metastatic potential of invasive breast cancer cells.

216 mpaired cell migration in vitro and also the metastatic potential of invasive lung cancer cells in vi

217 zygous mutation of Dpc4/Smad4 attenuates the metastatic potential of Kras(G12D/+);Trp53(R172H/+) panc

218 accessible biomarkers that may inform on the metastatic potential of localized prostate cancer are ur

219 orated by in vitro experiments assessing the metastatic potential of LS174T cells.

220 markers of hyperactive PR-A may help predict metastatic potential of luminal breast tumors.

221 CD24 knockdown decreased the metastatic potential of lung cancer cell lines resemblin

222 f miR-487b targets, and decreased growth and metastatic potential of lung cancer cells in vivo.

223 L1 expression negatively correlated with the metastatic potential of lung cancer cells.

224 migration/invasion capacity in vitro and the metastatic potential of MDA-MB-231 cells in immunodefici

225 topaxin reverted the invasive phenotypes and metastatic potential of metastatic HCC cells through reg

226 PSA enhanced the tumorigenic and metastatic potential of mouse melanoma cells in HDAC3- a

227 The metastatic potential of NME2-depleted cells was remarkab

228 portant for maintaining the invasiveness and metastatic potential of non-epithelial sarcoma cells.

229 rgistically and is sufficient to promote the metastatic potential of nonmetastatic cells to that of n

230 on in osteosarcoma, thus contributing to the metastatic potential of osteosarcoma cells by altering t

231 be pharmacologically targeted to inhibit the metastatic potential of pancreatic cancer cells.

232 sue samples and cell lines, and predicts the metastatic potential of pancreatic cancer.

233 not total talin1 expression, correlates with metastatic potential of PCa cells.

234 tivation is a novel mechanism that increases metastatic potential of PCa cells.

235 We conclude that P-AscH(-) attenuates the metastatic potential of PDAC and may prove to be effecti

236 n and messenger RNA were associated with the metastatic potential of PDAC cell lines and progression

237 syltransferase, which is associated with the metastatic potential of PDAC tumors in mice and progress

238 these targets in isolation did not alter the metastatic potential of sarcoma cells injected orthotopi

239 tion identifies metastatic cells; rather the metastatic potential of several ROS-generating mutations

240 iological marker that serves as a metric for metastatic potential of solid tumors.

241 enewal, gene expression, tumorigenicity, and metastatic potential of spheres at generations G1-G5 wer

242 sion levels did not change with the invasive/metastatic potential of the cancer cells or tumors.

243 The metastatic potential of the cancer cells was reduced aft

244 By assessing the metastatic potential of the double knockouts in mice, we

245 rget for molecular imaging of metastases and metastatic potential of the primary tumor.

246 coexist in SCC and that tumor initiation and metastatic potential of these populations can be uncoupl

247 anced the chemosensitivity and decreased the metastatic potential of this p53(null) claudin-low tumor

248 s been shown to enhance the invasiveness and metastatic potential of tumor cells by regulating the ge

249 cell adhesion and is thought to be linked to metastatic potential of tumor cells.

250 etastasis independent of origin or intrinsic metastatic potential of tumor cells.

251 nt in the allergic inflammation-promotion of metastatic potential of tumor cells.

252 c inflammation has been known to enhance the metastatic potential of tumor cells.

253 helial-mesenchymal transition to enhance the metastatic potential of tumor cells.

254 y, which could be associated with increasing metastatic potential of tumor cells.

255 relation between high expression of MLK4 and metastatic potential of tumors, which was predominantly

256 that hCDC14A may directly contribute to the metastatic potential of tumors.

257 n assessing patient prognosis and evaluating metastatic potential of various cancers will be presente

258 vascular remodeling, local tumor growth, and metastatic potential of various cancers.

259 blood vessels is important in the growth and metastatic potential of various cancers.

260 Finally, TBX3 overexpression exacerbates the metastatic potential of Wnt-dependent human colorectal c

261 In vivo metastatic potentials of both molecules were assessed.

262 thods to investigate the impact of increased metastatic potential on the biophysical properties and f

263 ing an U2OS osteosarcoma cell line with high metastatic potential, proven by a xenotransplant in zebr

264 the overlapping populations showed a higher metastatic potential relative to the other populations a

265 nd ER(+) subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-rel

266 dolent tumours with PTEN alterations acquire metastatic potential remains poorly understood.

267 Identification of the metastatic potential represents one of the most importan

268 bpd null mammary tumours, which have reduced metastatic potential, show altered expression of inflamm

269 verexpressed specifically in cells with high metastatic potential, suggesting a role for this miRNA a

270 tumor that has a worse prognosis and higher metastatic potential than its adenocarcinoma counterpart

271 evalent, CTC clusters appear to have greater metastatic potential than single CTCs in the circulation

272 ancer that has a worse prognosis and greater metastatic potential than the more common pancreatic duc

273 ds produced larger tumours and showed higher metastatic potential than WT cybrids.

274 pendymoma is a locally aggressive tumor with metastatic potential that arises in diverse locations th

275 fluidity as a necessary cellular feature of metastatic potential that can be controlled by many curr

276 ally related to changes in proliferation and metastatic potential that played the most significant ro

277 r epithelial ovarian cancer cells to acquire metastatic potential, the cellular phenotype at secondar

278 -overexpressing tumor cells to promote their metastatic potential through recruitment and bi-directio

279 motility, tissue invasion and acquisition of metastatic potential through the upregulation of epithel

280 een resistance to mTOR inhibition and cancer metastatic potential, thus enhancing our understanding o

281 erived exosomes have the ability to transfer metastatic potential to a recipient cell and cancer exos

282 om highly aggressive human TNBC cells impart metastatic potential to nonmetastatic cells.

283 n reduced primary tumor size and blocked the metastatic potential to the lungs.

284 target that enforces both proliferative and metastatic potentials to de-differentiated LPS cells.

285 Radiation-associated metastatic potential was evaluated using a wound-healing

286 ressing phenotype were identified, and their metastatic potential was studied in nude mice.

287 B-231 breast cancer cells that vary in their metastatic potential, we show that 3D refractive index t

288 ell viability, apoptosis, proliferation, and metastatic potential were analyzed.

289 In allograft studies, tumor growth and metastatic potential were significantly diminished by de

290 bladder carcinoma cell lines with differing metastatic potential were uncoupled from binding to targ

291 mors appear to have had a biologic impact on metastatic potential, whereas mutations arising in the m

292 2 cm in diameter since they frequently show metastatic potential, whereas smaller panNETs are genera

293 linked with the expansion of subclones with metastatic potential which we can detect in the blood.

294 r (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to

295 B-231 and BT-549 cancer cells stimulated the metastatic potential while it actually inhibited it in t

296 and CCL28 were expressed in tumor cells with metastatic potential, while their cognate receptor, CCR1

297 exhibited a slower growth rate and a reduced metastatic potential with a more differentiated epitheli

298 a malignancy characterized by high invasive/metastatic potential, with no efficient therapy after me

299 Melanomas are characterized by high metastatic potential, with regional lymph node represent

300 y serve as a stable marker for migration and metastatic potential within a given tumor population and