ライフサイエンスコーパス: metazoa

1 chizosaccharomyces pombe) to hetero-nonamer (Metazoa).

2 adhesion such as integrin beta subunits (all Metazoa).

3 xclusively in animal organisms (Protozoa and Metazoa).

4 via chemical reaction, is widespread across Metazoa.

5 variation of visual organs found across the Metazoa.

6 a noxious chemical sensor throughout much of Metazoa.

7 for coordinating developmental activities in metazoa.

8 m, evolved to diversify the transcriptome in metazoa.

9 tors (GPCRs), the largest receptor family in Metazoa.

10 ad mechanism to alter genetic information in metazoa.

11 the T-box family diversified at the onset of Metazoa.

12 s - many ciliate cells are larger than small metazoa.

13 ukaryotes prior to the origins of neurons in metazoa.

14 f ECM proteins to serve diverse functions in metazoa.

15 ran-Cambrian (578-510 Ma) diversification of Metazoa.

16 in allorecognition responses throughout the metazoa.

17 een groups of cells allowed the evolution of metazoa.

18 t, stress response, and energy metabolism in metazoa.

19 conserved master stress-response pathway in metazoa.

20 transcription factor binding sites among the metazoa.

21 premeiotic S phase remains poorly defined in metazoa.

22 sues can be traced to a soft tissue in early Metazoa.

23 by which to investigate protein function in metazoa.

24 cis-regulation of key developmental genes in Metazoa.

25 hat have been primarily studied in yeast and metazoa.

26 llular matrix is one defining feature of all Metazoa.

27 tRNAs, and two rRNAs) typically found in the metazoa.

28 and effector systems in this clade of basal Metazoa.

29 nt of the phylum Placozoa at the root of the Metazoa.

30 and bacterial pathogens but are absent from metazoa.

31 has been implicated as a cause of ageing in metazoa.

32 al homologs, as opposed to homologs in other Metazoa.

33 ent and maintenance of tissue homeostasis in metazoa.

34 unicellular pathogenic eukaryotes but not in Metazoa.

35 ly, it shares derived features unique to the Metazoa.

36 ct molecular clock cannot be assumed for the Metazoa.

37 n formation and morphogenesis throughout the metazoa.

38 arried out to determine its placement within Metazoa.

39 igands determines a variety of cell fates in metazoa.

40 the formation/function of tight-junctions in metazoa.

41 originally used later in development by all metazoa.

42 common ancestor of trichomonads, yeast, and metazoa.

43 f Fungi of approximately the same age as the Metazoa.

44 of another--is a universal phenomenon in the Metazoa.

45 incomplete DNA replication during mitosis in metazoa.

46 zation in many other contexts throughout the Metazoa.

47 e important modulators of origin activity in metazoa.

48 ence for origins has yet to be identified in metazoa.

49 ating conservation of NR functions among the Metazoa.

50 84 NR genes are 15 genes conserved among the Metazoa.

51 the greatest diversity of body plans in the Metazoa.

52 m cell specification may be ancestral to the Metazoa.

53 imeric CDK7-cyclin H-Mat1 in human and other metazoa.

54 ceptors that regulate cell fate decisions in metazoa.

55 east (Saccharomyces cerevisiae), but lost in Metazoa.

56 aradigm for the complex origins found in the metazoa.

57 ment membrane (BM) proteins conserved in all metazoa.

58 le is known about the ORC-DNA interaction in metazoa.

59 hyly of Bilateria, Cnidaria, Ctenophora, and Metazoa.

60 ukaryotes, spanning unicellular organisms to metazoa.

61 and that may be linked to the origin of the Metazoa.

62 trast to their generally exonic locations in metazoa.

63 ell signalling evolved before the origins of metazoa.

64 ns that regulate cellular polyamine pools in metazoa.

65 und to generally correlate with longevity in Metazoa.

66 from the common ancestral line of all other Metazoa.

67 before the origin of angiosperms, fungi, and metazoa.

68 ly component of the regulatory mechanisms of metazoa.

69 program in embryonic patterning in the lower Metazoa.

70 As from genes is an ubiquitous phenomenon in metazoa.

71 ctions with MCM are broadly conserved across Metazoa.

72 ories, including those gained in the path to Metazoa.

73 ellates, the closest unicellular relative of Metazoa.

74 in a common ancestor of Choanoflagellida and Metazoa.

75 nservation of acylation site patterns across metazoa.

76 pisthokonta than did the gene repertoires of Metazoa.

77 c guides to repress complementary targets in Metazoa.

78 lication initiation in vitro is conserved in metazoa.

79 ssential meiotic functions in species across metazoa.

80 ired for building robust mitotic spindles in metazoa.

81 of oxidative phosphorylation and the rise of metazoa.

82 te for the evolution of defining features of Metazoa.

83 ns unclear how UPF1 is activated outside the metazoa.

84 he worm, which indicates a conserved role in metazoa.

85 apical polarity may be conserved throughout Metazoa.

86 asymmetric) within the division plane across Metazoa.

87 gous to lamins, the major lamina proteins of metazoa.

88 ic and regulatory evolution after WGD in the Metazoa.

89 rged as regulators of gene expression across metazoa.

90 lated in honey bees are conserved across the Metazoa.

91 esses transposable elements in germ cells of Metazoa.

92 and gene expression are conserved among the Metazoa.

93 obacterium, replaced the ancestral enzyme in Metazoa.

94 d the cytoplasmic fates of messenger RNAs in metazoa.

95 an regulation and their evolution within the Metazoa.

96 , transmembrane protein conserved throughout Metazoa.

97 BAF nucleosome-remodeling complex in vivo in metazoa.

98 n of integrative and effector systems across Metazoa.

99 verse transposable elements in germ cells of metazoa.

100 r to annotate data sets from taxa outside of Metazoa.

101 onary forces and constraints observed across metazoa.

102 ys in a variety of cell types throughout the Metazoa.

103 bond, is evolutionarily conserved throughout Metazoa.

104 ce Ctenophora as the earliest lineage within Metazoa.

105 e thymidine kinase 2-like dNK gene family in metazoa.

106 ficity of Brachyury emerged at the origin of Metazoa.

107 onserved structures and functions across the Metazoa.

108 ay, a major growth regulatory pathway within metazoa [4], but at least in some instances, the influen

109 SCF(Dia2) in budding yeast(1), CUL2(LRR1) in metazoa(4-7)), replisome disassembly is governed by a co

110 es in eukaryotes, including at the origin of Metazoa, 650-850 million years ago.(1)(,)(2)(,)(3)(,)(4)

111 onstitute the most species-rich radiation of metazoa, a success that is due to the evolution of activ

112 cally important processes, and that for many metazoa, A-to-I conversion in coding regions may be the

113 All metazoa also have a membrane-associated Wee1p-like kinas

114 in addition to 55 genomes from invertebrate metazoa and 39 genomes from plants.

115 d to assemble 374 mitochondrial genomes (368 Metazoa and 6 Fungi species) for the Darwin Tree of Life

116 The formation of filopodia in Metazoa and Amoebozoa requires the activity of myosin 10

117 te decisions are likely to be conserved with metazoa and are providing insight into differentiation d

118 ein SAS-4 regulates centriole duplication in metazoa and basal body duplication in flagellated and ci

119 lex in a stem-holozoan, the ancestor of both Metazoa and Choanoflagellata, the protozoan group most c

120 onges (Phylum Porifera) are among the oldest Metazoa and considered critical to understanding animal

121 ges (i.e., those with embryonic development, Metazoa and Embryophyta) have the most complex TF repert

122 Metazoa and Fungi also show differences regarding gene g

123 netic changes that accompanied the origin of Metazoa and Fungi since the divergence of Opisthokonta w

124 y restricted to the supergroup Opisthokonta (Metazoa and Fungi), whereas proteins with the ELMOD orga

125 (Dd), a member of the Amoebazoa outgroup of Metazoa and Fungi, and show that it has a highly simplif

126 In metazoa and fungi, the catabolic dissimilation of cystei

127 exts thus set the stage for the emergence of Metazoa and Fungi.

128 BC10 is highly conserved across a range of metazoa and has been implicated in two forms of cancer.

129 nelles, therefore, pre-date the evolution of Metazoa and have broader and more conserved functions th

130 ts determine an essential function of CDK in metazoa and identify a developmental role for regulated

131 This novel domain (NZF) is conserved in metazoa and is both present and functional in other prot

132 ned the differences between the proteomes of Metazoa and other eukaryotes.

133 aryotes and of non-bilaterian and bilaterian Metazoa and performed phylogenetic analyses to gain insi

134 analysis of published BiFC fragments used in metazoa and plants, and then developed an optimized sing

135 Genes related to Cdt1 have been found in Metazoa and plants, suggesting that the cooperation of C

136 ae in a common lineage distinct from that of metazoa and plants.

137 xual dimorphism is widespread throughout the metazoa and plays important roles in mate recognition an

138 al processes in a wide variety of organisms, metazoa and protists alike.

139 f the mechanism of cell cycle checkpoints in metazoa and provides a marker for studying the role of t

140 dicted rearrangement pathway is conserved in Metazoa and requires an external factor that initiates s

141 range of processes, including cytokinesis in Metazoa and some Archaea.

142 in visual system development throughout the metazoa and the function of Pax6 is evolutionarily conse

143 /nitrate sensors from the common ancestor of Metazoa and the preservation of conservative NOS archite

144 It comprises two major clades: (i) the Metazoa and their unicellular relatives and (ii) the Fun

145 Collagen IV networks are present in all metazoa and underlie epithelia as a component of basemen

146 3 orthologous families that were specific to Metazoa and were likely to have originated in their last

147 nts culminating in the emergence of animals (Metazoa) and new ecosystems.

148 ing proteins present broadly across animals (Metazoa), and in vertebrates form flask-shaped invaginat

149 hways not found in KEGG, from plants, fungi, metazoa, and actinobacteria; KEGG contains pathways not

150 each containing sequences from angiosperms, metazoa, and fungi.

151 ubiquitous sensory ability found across the Metazoa, and photoreceptive organs are intricate and div

152 inst PBGS orthologs from bacteria, protozoa, metazoa, and plants to elucidate the inhibitory spectrum

153 hitecture, with highly shared synteny across Metazoa, and suggest that adaptation to the extreme temp

154 dherens junctions have only been detected in metazoa, and therefore we looked for them outside the an

155 a major selective force in the evolution of metazoa, and thus plasticity in tissue function and morp

156 r event in the stem lineage of Holozoa, i.e. Metazoa (animals) and their unicellular relatives, the C

157 ned at the molecular level, is unique to the Metazoa (animals).

158 seen during the split between fungi and the Metazoa approximately 1.0-1.2 Ga, at a time when oceanic

159 ing multicellular, all five clades of extant Metazoa are diploid organisms that reproduce via eggs an

160 sly characterized modification guide RNAs in metazoa are encoded in and processed from introns.

161 The genomes of metazoa are organized at multiple scales.

162 studies of transcriptional regulation in the metazoa are significantly hindered by the absence of rea

163 ex systems, which control gene expression in metazoa, are helping researchers identify fundamental th

164 long and highly charged C-terminal tails, in metazoa as well as in yeast.

165 OSA-1, a cyclin-related protein conserved in metazoa, as a key component required to convert meiotic

166 e trophic basis of production for freshwater metazoa at broad spatial scales is key to understanding

167 icate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are no

168 at DNA replication in multicellular animals (metazoa) begins at specific origins to which a pre-repli

169 large intracellular domain (ICD) present in metazoa (between transmembrane segments M3 and M4).

170 a, the group of Choanozoa that is closest to Metazoa, both the ancestral and the horizontally transfe

171 0 residues which also is highly conserved in Metazoa but is absent in Sc-Nup120.

172 shares many general cellular properties with metazoa, but has no identified cell suicide machinery.

173 n organizing developmental patterning across metazoa, but how these factors trigger regional morphoge

174 ologs of ELL and EAF have been identified in metazoa, but it has been unclear whether such RNA polyme

175 otal regulator of eye development throughout Metazoa, but the direct upstream regulators of vertebrat

176 highest rates of meiotic recombination among Metazoa, but there is considerable variation within the

177 been implicated in age-associated decline in metazoa, but they have only been identified in extracell

178 l migration, survival and differentiation in metazoa by communicating signals bi-directionally across

179 In metazoa cap 1 (m(7)GpppNmp-RNA) is linked to higher leve

180 In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiqui

181 zoan germ lines.(7) The closest relatives of Metazoa, Choanoflagellata, encode orthologs of Kif23 and

182 xport protein Yra1 (ALY/RNA export factor in metazoa) cotranscriptionally associates with mRNA and de

183 inference, the last common ancestor (LCA) of Metazoa could produce sperm and eggs and could cleave fe

184 of proteins involved in cell interactions in Metazoa demonstrates that these proteins evolved before

185 ia, protists, fungi, plants and invertebrate metazoa) designed to complement the availability of vert

186 In metazoa, distinct stress conditions activate different e

187 In metazoa, DNA elimination typically occurs in somatic cel

188 In metazoa, DNA sequence elements involved in origin specif

189 dea that transfers would be less relevant in Metazoa due to germline isolation(3-5).

190 ur in a wide range of phyla, particularly in Metazoa, due to a reduced "proteomic constraint" on the

191 The Metazoa encompasses inordinate lineages of symbionts and

192 ing ATF4 control are conserved in the entire metazoa except nematoda.

193 Despite being bilaterally symmetric, most Metazoa exhibit clear, genetically determined left-right

194 single function, but most proteins (>80% in Metazoa) exist as multi-domain proteins.

195 egulate neuronal morphogenesis in developing metazoa (for review, see [1]).

196 Biomineralization is the process by which metazoa form hard minerals for support, defense, and fee

197 rucial role in safeguarding the germlines of metazoa from mobile DNA elements.

198 The evolution of the Metazoa from protozoans is one of the major milestones i

199 asement membranes that underlie epithelia in metazoa from sponge to human.

200 mplex benthic ecosystems that have sustained Metazoa from the Ediacaran Period onward.

201 ated hormones regulate key life processes in Metazoa, from metabolism to growth, lifespan and aging,

202 35 kDa), the heteromeric partner of CFD1 in metazoa, functions on its own in plants.

203 In metazoa, growth factors trigger conversion of Ras from a

204 etic position of the Chaetognatha within the Metazoa has long been uncertain, with conflicting or equ

205 nd the first sequence of a linear mtDNA from Metazoa - has been determined.

206 This suggests that metazoa have evolved specific molecular mechanisms to ad

207 cysteine proteases in primitive protozoa and metazoa have suggested that this enzyme family is more d

208 Both land plants and metazoa have the capacity to reprogram differentiated ce

209 lution involved deployment of VWA domains by Metazoa in extracellular proteins involved in cell adhes

210 y marine demosponges, record the presence of Metazoa in the geological record before the end of the M

211 ADPGK is found in Archaea and metazoa; in Archaea, ADPGK participates in a glycolytic

212 lexity of the DNA damage response network in metazoa including the evolution of other BRCT domain-con

213 Par proteins are highly conserved across Metazoa, including ctenophores.

214 s that are required for cadherin function in Metazoa, including cytoskeleton organization, cell-subst

215 teraction is evolutionarily conserved across metazoa, indicating its significance.

216 Cell division in many metazoa is accompanied by the disassembly of the nuclear

217 ng the mechanisms and consequences of PDE in metazoa is lacking.

218 The appearance of PONs in metazoa is likely to relate to innate immunity rather th

219 cell cycle and developmental transitions in metazoa is poorly understood.

220 CstF-64, a small region, highly conserved in metazoa, is responsible for interactions with two protei

221 Curiously, metazoa lack Hsp78.

222 In metazoa, lamin proteins preserve nuclear integrity and h

223 for the notion that origin specification in metazoa likely involves mechanisms other than simple rep

224 tions and lineage specific expansions in the metazoa lineage.

225 rphic histocompatibility loci common to many metazoa may have arisen or been maintained: to limit sup

226 The acquisition of O-GlcNAc signaling by metazoa may have facilitated the rapid and complex signa

227 to our knowledge, identified outside of the Metazoa, MBRTK1.

228 In metazoa multiple gamma-TuSCs assemble with other protein

229 While in metazoa, NAA50 has N-acetyltransferase activity, yeast N

230 Intercellular communication in metazoa not only requires autocrine, paracrine and exocr

231 In metazoa, nuclear pore complexes (NPCs) assemble from dis

232 ration was shown to occur in: (i) the LCA of Metazoa or (ii) independently in the Metazoan phyla.

233 te-have been purified and characterized from metazoa or their viruses.

234 ng in fission yeast and show that similar to metazoa, ORC binding is periodic during the cell cycle,

235 In metazoa, PDE often occurs coincident with germline to so

236 Across Metazoa, Piwi proteins play a critical role in protectin

237 Metazoa possess protein disaggregase systems distinct fr

238 It appears that most metazoa possess sequences encoding a single highly conse

239 ila eye development but broadly conserved in metazoa, possesses dual functions as a transcriptional c

240 In metazoa, pre-mRNA 3' end formation occurs via two pathwa

241 stly Rhizaria, Syndinales, and ciliates) and metazoa (predominantly pelagic mollusks and cnidarians)

242 ip between IBP39 and Inr-binding proteins in metazoa presents interesting evolutionary questions.

243 In Metazoa, promoters of transcriptionally active genes are

244 of a conserved nucleotide sequence that, in metazoa, promotes a +1 programmed ribosomal frameshift r

245 and the discovery of several Ediacaran crown-Metazoa prompt recalibration of molecular clock analyses

246 Understanding how metazoa protect their genomes from mutagenic retrovirus

247 OrthoVenn provides coverage of vertebrates, metazoa, protists, fungi, plants and bacteria for the co

248 er number of species, including vertebrates, metazoa, protists, fungi, plants and bacteria, have been

249 lar and colonial protozoa closely related to Metazoa, provide a potential window into early animal ev

250 n of RtcB proteins in bacteria, archaea, and metazoa raises the prospect of an alternative enzymology

251 a protein resembles nonmuscle myosin-2s from metazoa rather than protozoa, though modulatory aspects

252 In metazoa, re-replication of DNA during a single S phase s

253 n in bacteria, but their characterization in Metazoa remains limited.

254 he evolutionary responses to this outside of Metazoa remains unclear.

255 ponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symb

256 Filopodia formation in Amoebozoa and Metazoa requires the phylogenetically diverse MyTH4-FERM

257 prevalence of such organisms throughout the Metazoa requires us to refine our preconceptions of conf

258 n strategy to achieve cell type diversity in metazoa, results from binary cell-fate decisions in the

259 In metazoa, RtcB functions as part of a five-subunit tRNA l

260 The gene order, although unique amongst Metazoa, shared the greatest number of gene boundaries a

261 In MTBP the conserved termini flank the metazoa-specific Cdk8/19-cyclin C binding region and are

262 ur characterisation of broadly conserved and metazoa-specific initiation processes sets the basis for

263 ve analysis of MTBP and reveal conserved and metazoa-specific MTBP functions in replication.

264 We uncover one such metazoa-specific process: a new replication factor, cycl

265 In yeast and metazoa, structural maintenance of chromosome (SMC) comp

266 orax as Arthropoda and Chordata emerged from Metazoa suggesting that Taspase1 originated to regulate

267 e relationship between choanoflagellates and Metazoa, suggesting that comparison of the complement of

268 tilization and prior to pronuclear fusion in metazoa, suggesting that newly transcribed genes appear

269 ucity of peptidase families unique to higher metazoa suggests gains in proteolytic network complexity

270 ence of domains in repeats is more common in metazoa than in single cellular organisms.

271 adthrough is significantly more prevalent in Metazoa than previously recognized.

272 deaminase (ADAR1) is an ubiquitous enzyme in metazoa that edits pre-mRNA changing adenosine to inosin

273 rins are important adhesion receptors in all Metazoa that transmit conformational change bidirectiona

274 Reference genomes for metazoa that undergo DNA elimination are not available.

275 nd cleavage and polyadenylation, although in metazoa the replication-dependent histone mRNAs are proc

276 he center of discussions of the evolution of Metazoa, the biology of survival in extreme environments

277 ause neural systems are almost ubiquitous in metazoa, the constitutive expression of neuroglobin-like

278 es by directly modulating gene expression in Metazoa, the regulatory pathways for sensing and respond

279 nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins.

280 Since their discovery in Metazoa, the three nuclear RNA polymerases (RNAPs) have

281 -1 was the first genetic locus identified in metazoa to affect the distribution of meiotic crossovers

282 model, and calibration strategy, we estimate Metazoa to have originated in the early Ediacaran, Eumet

283 nction throughout development and across the metazoa to regulate cell polarity.

284 ial process that occurs in female meiosis of metazoa to reset centriole number in the zygote at ferti

285 In metazoa, TREX is loaded on nascent RNA transcribed by RN

286 In archaea and metazoa, tRNA exons are ligated by the RNA ligases RtcB

287 Ran interacts with the NPC of metazoa via two asymmetrically localized components, Nup

288 ecklist, a biodiversity inventory of benthic metazoa vital to future assessments of environmental imp

289 We conclude that evolution in the LCA of Metazoa was extensive and proceeded largely by gene dupl

290 in eukaryotes distantly related to yeast and metazoa, we characterized the Trypanosoma brucei SCC1 or

291 y governs cellular differentiation in higher metazoa, where Notch signals are transduced by the trans

292 In metazoa, where VPS13, but not ERMES, is present, the Gem

293 Gene fusions are more prevalent in Metazoa, whereas a larger fraction of gene gains were de

294 y of cysteine proteases conserved across all metazoa which play critical functions that range from ce

295 sin, a novel metalloprotease present only in metazoa, whose activity appears to be essential for mito

296 hat diverse SelenoP genes are present across metazoa with highly variable numbers of Sec-UGAs, rangin

297 c link between lineage-defining asymmetry of metazoa with unicellular eukaryotes.

298 Conversely, those metazoa with unlimited cellular replicability, by stavin

299 Whole-body regeneration is widespread in the Metazoa, yet little is known about how underlying molecu

300 cental mammals, early vertebrates, and early metazoa, yielding results consistent with, but more prec