ライフサイエンスコーパス: metazoan

1 observed in most expressed genes across the metazoan.

2 s not been previously directly analyzed in a metazoan.

3 tial component of developmental signaling in metazoans.

4 n whether this phenomenon is observed across metazoans.

5 mmunication to promote health and fitness in metazoans.

6 are key regulators of cellular functions in metazoans.

7 ene expression patterns and cell identity in metazoans.

8 ple acetyltransferase complexes in yeast and metazoans.

9 tion previously reported as ubiquitous among metazoans.

10 that control organismal morphogenesis across metazoans.

11 y the p107 and p130 Rb-family members across metazoans.

12 nslational regulation, much less is known in metazoans.

13 regulate cell fate during development of all metazoans.

14 evolved differently to the system present in metazoans.

15 ozoa is essential for sexual reproduction in metazoans.

16 ctive members catalyze A-to-I RNA editing in metazoans.

17 d on nuclear and cytoplasmic proteins in all metazoans.

18 ygenated niches for the evolution of benthic metazoans.

19 c endosymbionts in a variety of protists and metazoans.

20 ty along the anterior-posterior body axis in metazoans.

21 r contributors to genome-size differences in metazoans.

22 ay are thought to be highly conserved across metazoans.

23 he highly conserved Wnt signaling pathway in metazoans.

24 tes diverse cellular processes in plants and metazoans.

25 egments, which contain extended tentacles in metazoans.

26 suppress differentiation pathways formed in metazoans.

27 s ranging from unicellular microorganisms to metazoans.

28 s a well-known impact on stress responses in metazoans.

29 developmental and physiological processes in metazoans.

30 complex in yeast has never been described in metazoans.

31 n germline development and genome defence in metazoans.

32 life, including as the closest relatives of metazoans.

33 tions of newly emerging genes, especially in metazoans.

34 the immense untapped metabolic potential of metazoans.

35 and no apparent ClpB orthologs are found in metazoans.

36 mitochondrial activities in the emergence of metazoans.

37 ch forms or lines many tissues and organs in metazoans.

38 and analyses of neuronal evolution in basal metazoans.

39 ntribute to Mcm2-7 loading site selection in metazoans.

40 cause protein misfolding and aggregation in metazoans.

41 expression to govern organismal survival in metazoans.

42 gmatic phylum of simple, microscopic, marine metazoans(1,2).

43 ble channels, with rapid kinetics resembling metazoan 4D-Ca(v)s/Na(v)s.

44 e mitochondrial calcium uniporter complex in metazoans, a highly selective and tightly controlled Ca(

45 In all metazoans, a small number of evolutionarily conserved si

46 ighting the coeval appearance of macroscopic metazoans across two paleocontinents.

47 Tribbles pseudokinases, which only exist in metazoans, act as scaffolds that interact with COP1 and

48 Hence, we have named it the metazoan 'ADA complex'.

49 tasia and Rad3-related protein (ATR), and in metazoan also by DNA-dependent protein kinase catalytic

50 Thus, metazoan and bacterial responses differ dramatically, su

51 diversified from ancestral genes across the metazoan and plant kingdoms to establish multicellularit

52 functional compatibility expands between the metazoan and plant kingdoms, illustrating striking conse

53 in the distinct DNA sequence-dependencies of metazoan and S. cerevisiae initiators in origin recognit

54 We show here that metazoan and stramenopile OUC enzymes share common origi

55 (2+) is the most abundant divalent cation in metazoans and an essential cofactor for ATP, nucleic aci

56 The Integrator complex is conserved across metazoans and controls the fate of many nascent RNAs tra

57 his Review, we present an overview of ETI in metazoans and discuss recently described cellular proces

58 lude 15, 24 and 16 super families in plants, metazoans and fungi, respectively.

59 Small RNA pathways are highly conserved in metazoans and have been best described for the model org

60 NF-Y is a central player in TSS selection in metazoans and highlight the deleterious consequences of

61 ng conserved UPR elements between plants and metazoans and highlighting unique plant-specific feature

62 and their critical roles in the emergence of metazoans and in human disorders.

63 is the principal mechanism for ICL repair in metazoans and is coupled to DNA replication.

64 e for defence chemicals in the oldest-living metazoans and paves the way towards discovering similar

65 involved in regulation of gene expression in metazoans and plants.

66 Gap junctions are ubiquitous in metazoans and play critical roles in important biologica

67 of thrombospondin type 1 repeats present in metazoans and recently identified also in apicomplexan p

68 s include integrin alphabeta heterodimers in metazoans and single subunit transmembrane proteins in a

69 for understanding homologous biology within metazoans and the evolution of metazoan traits.

70 lum chemical interactions occurs between all metazoans and their microbiomes.

71 Comparative studies of metazoans and their relatives now allow reconstruction o

72 ed nutrients is an essential function of all metazoans and utilizes a wide array of nutrient transpor

73 ongs to the cornerstone of the metabolism of metazoans and, as found recently, also photosynthetic st

74 G, FBX8, and TBS) are opisthokont, holozoan, metazoan, and alveolate/haptophyte specific, respectivel

75 paused at promoter-proximal regions in most metazoans, and based on in vitro studies, this function

76 yl pyrophosphate (HMBPP), is not produced in metazoans, and in humans and other primates it activates

77 the unicellular alga Chlamydomonas, several metazoans, and land plants, emerging evidence indicates

78 valent cells during development in bacteria, metazoans, and plants.

79 -sensing pathways were adopted in plants and metazoan animals, and include ubiquitin-mediated degrada

80 from ~550 to 547 Ma, when the first skeletal metazoans appeared.

81 Precise patterns of gene expression in metazoans are controlled by three classes of regulatory

82 The genomes of non-bilaterian metazoans are key to understanding the molecular basis o

83 Oxygen sensing is central to metazoan biology and has implications for human disease.

84 ine neurotransmitters play a central role in metazoan biology, and both their chemical structures and

85 bditis elegans is a key laboratory model for metazoan biology.

86 ese genes have been lost from the genomes of metazoans but are otherwise conserved as single-copy gen

87 of the mitotic spindle direct cytokinesis in metazoans but this has not been documented in fungi.

88 aspects of brain development and behavior in metazoans, but how they enter the central nervous system

89 e tube-dwellers are presumed to be primitive metazoans, but resolving their phylogenetic identity has

90 mosome alignment is a hallmark of mitosis in metazoans, but the physiological relevance of this order

91 been considered the earliest biomineralizing metazoans, but their affinities have remained contentiou

92 ) are important for genome regulation across metazoans, but their biogenesis evolves rapidly.

93 strated here that heterologous expression of metazoan, calcium-dependent, membrane-binding proteins o

94 d a new class of circular non-coding RNAs in metazoans, called tRNA intronic circular (tric)RNAs.

95 Thus, NXF variants, which are abundant in metazoans, can have diverse molecular functions and migh

96 Orc6 in metazoans carries a structural homology with transcripti

97 ine protease family, structurally related to metazoan caspases.

98 of the varied catalytic activities found in metazoan CCDs, opening the possibility of modifying thei

99 Teneurins are ancient metazoan cell adhesion receptors that control brain deve

100 In metazoan cell nuclei, heterochromatin constitutes large

101 Metazoan cell polarity is controlled by a set of highly

102 ransduction pathway found in most if not all metazoan cell types characterized to date.

103 The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the

104 Most metazoan cells entering mitosis undergo characteristic r

105 ever, the mechanisms of this upregulation in metazoan cells remain poorly understood.

106 been recently implicated in ciliogenesis in metazoan cells, and our data suggest that this kinase ha

107 in microtubule organizing centers (MTOCs) of metazoan cells, contain an older "mother" and a younger

108 envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy

109 In this review, focusing mostly on metazoan cells, we discuss how different types of local

110 he specific requirements of the more complex metazoan cells.

111 mediates the adhesion and migration of many metazoan cells.

112 n (PLXN) receptors are central regulators of metazoan cellular communication.

113 conformations of these functionally similar metazoan channels.

114 The repeating structural unit of metazoan chromatin is the chromatosome, a nucleosome bou

115 Metazoan chromosomes are sequentially partitioned into t

116 epsilon (CK1) plays a key regulatory role in metazoan circadian rhythms.

117 In metazoans, circular RNAs are expressed in a tissue-speci

118 networks by analyzing >16,000 predominantly metazoan co-fractionation and affinity-purification mass

119 created a stressful environment for benthic metazoan communities.

120 Metazoan complexity and life-style depend on the bioener

121 Metazoan CTDs have well-conserved lengths and sequence c

122 All metazoans depend on the consumption of O(2) by the mitoc

123 beta-catenin signaling pathway is central to metazoan development and routinely dysregulated in cance

124 Innovations in metazoan development arise from evolutionary modificatio

125 cell death and stem cell biology, studies of metazoan development have historically opened new fields

126 Metazoan development requires the robust proliferation o

127 During metazoan development, immune surveillance and cancer dis

128 quiescence are intimately coordinated during metazoan development.

129 ins with spatial and temporal control during metazoan development.

130 cell polarization and directed migration in metazoan development.

131 ressing questions regarding the evolution of metazoan developmental processes and nervous system func

132 nce of neutral processes suggests that early metazoan diversification may not have been driven by sys

133 We argue that early metazoan diversification should be recast as a series of

134 The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking th

135 Some of the oldest known metazoan-dominated paleocommunities occur in Ediacaran a

136 barcoding data indicated a die-off of larger metazoans during the first week of study and gradual red

137 nd function in morphogenetic events in early metazoan embryogenesis has not been carried out.

138 Control of metazoan embryogenesis shifts from maternal to zygotic g

139 Most metazoan embryos commence development with rapid, transc

140 In turn, metazoans employ surveillance mechanisms such as the mit

141 The metazoan endoplasmic reticulum (ER) serves both as a hub

142 select NMD targets, despite the lack of the metazoan endoribonuclease SMG6 in plants.

143 A), a DNA modification not commonly found in metazoan epigenomes.

144 ctively affects the dynamics of the abundant metazoan ER Hsp70 chaperone BiP, by enhancing its affini

145 enomes found in prokaryotes and in a few non-metazoan eukaryotes.

146 so been reported in some vertebrates and non-metazoan eukaryotes.

147 remarkable conservation of function amongst metazoans, even though components present in invertebrat

148 tions have been frequently redeployed during metazoan evolution to regulate specialized developmental

149 s is one of the most challenging problems in metazoan evolution(1,2).

150 nce of different junctional complexes during metazoan evolution.

151 novation of programmed cell suicide early in metazoan evolution.

152 ten underlie the evolutionary origins of key metazoan features.

153 supply will increase organic matter flows to metazoan food webs in detritus-based ecosystems by reduc

154 h which basal resources were channelled into metazoan food webs was not propagated to macroinvertebra

155 constrain their phylogenetic position to the metazoan (for Rangeomorpha) or eumetazoan (e.g., Arborea

156 Cadherin-based cell-cell junctions help metazoans form polarized sheets of cells, which are nece

157 amples of enigmatic, putative shell-building metazoan fossils.

158 iscarpa, a bilaterally symmetrical, solitary metazoan from the early Cambrian (Fortunian) of China wi

159 Coevolution of Tribbles and the PSL in metazoans further underscores the importance of this rol

160 associate to form a ring-like structure (in metazoans, gamma-tubulin ring complex; gamma-TuRC) [1-7]

161 Even so, its role in metazoan gene expression is underappreciated.

162 e elongation is a central, regulated step in metazoan gene expression.

163 al enhancers play a major role in regulating metazoan gene expression.

164 over a previously unappreciated mechanism of metazoan gene repression, akin to bacterial transcriptio

165 ene structure analyses of H3.3 genes from 32 metazoan genomes indicate independent evolutionary paths

166 s in their genomes, this number is higher in metazoan genomes, suggesting a spatiotemporal and functi

167 ying TADs across a vastly increased range of Metazoan genomes.

168 exhibiting extreme noncoding conservation in Metazoan genomes.

169 n (APA), is a broad and conserved feature of metazoan genomes.

170 In the metazoan germline, their mobilization is limited by a cl

171 coordination of growth and patterning across metazoans gives rise to a diversity of sizes and shapes

172 ted both the distinct evolutionary record of metazoan groups during the Cambrian Explosion and determ

173 lution changes in species body size in major metazoan groups on the Siberian Platform during the earl

174 However, in vivo depletion of GORASPs in metazoans has given equivocal results.

175 oteins, the highly repetitive centromeres of metazoans have been refractory to DNA sequencing and ass

176 HP1) encodes the only plant homologue of the metazoan HETEROCHROMATIN PROTEIN1 (HP1) protein family.

177 n bacterial physiology and modulation of the metazoan host innate immune system.

178 a prominent role for 2'3'-cGAMP cleavage in metazoan host-pathogen conflict.

179 s detrimental to the long-term health of the metazoan host.

180 nnel-expressing pacemaker cells in the basal metazoan Hydra by using a combination of single-cell tra

181 identify two key regulatory elements of the metazoan hypoxia response, namely the transcription fact

182 We show that metazoan identifications in GenBank are surprisingly acc

183 s, a hyper-abundant and functionally diverse metazoan in terrestrial ecosystems.

184 ns may have promoted the appearance of large metazoans in the early Cambrian.

185 such linkage for copepods, the most abundant metazoans in the oceans, remains scarce, particularly fo

186 orders of magnitude those observed in other metazoans, including humans, and closely mirror the open

187 as a key mechanism of antiviral immunity in metazoans, including the selective elimination of viral

188 that followed the acquisition of STING into metazoan innate immunity, and determine the structure of

189 Mitosis in metazoans involves detachment of chromosomes from the nu

190 ding of functionally analogous mechanisms in metazoans is still emerging.

191 hinoderms, while in many other phyla, across metazoans, it controls tubulogenesis and vascularization

192 For anterior-posterior (AP) patterning in metazoans, it has been suggested that the gradual transi

193 standing of evolutionary forces underpinning metazoan life at the limits of small physical and genome

194 ess this knowledge gap through analysis of a metazoan-like archaeal CCD from Candidatus Nitrosotalea

195 descendants of one of the earliest branching metazoan lineage with enigmatic nervous systems.

196 Ctenophora is an early-branching basal metazoan lineage, which may have evolved neurons and mus

197 of neuromuscular organization in this basal metazoan lineage.

198 sent in Cnidaria [6-8], an earlier-branching metazoan lineage.

199 However, distinct from the metazoan machinery, repression of gene expression is pri

200 nd utilizes similar in vivo cofactors as the metazoan maintenance methylase Dnmt1.

201 We propose that the evolution of metazoans may have been facilitated by a series of dynam

202 in the EMRE-dependent gating mechanism among metazoan MCUs.

203 Metazoan Mdm2 binding protein (MTBP) forms a main regula

204 Metazoan microRNAs require specific maturation steps ini

205 ives, revealing alternative trajectories for metazoan miRNA evolution.

206 Hence, whether metazoan mitochondria reactivate aggregated proteins is

207 With the rapid increase of sequenced metazoan mitochondrial genomes, a detailed manual annota

208 cated tool for fully automatic annotation of metazoan mitochondrial genomes.

209 Here we analyze the metazoan mitochondrial sequences of GenBank using a comb

210 into neural development and the rise of the metazoan nervous system.

211 n linked to a variety of cataphract Cambrian metazoans, notably Wiwaxia and the halkieriids, but rece

212 The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known

213 Transcriptional regulation in metazoans occurs through long-range genomic contacts bet

214 Our findings provide the first evidence in a metazoan of a PDGF/VEGF ligand acting as a myokine that

215 ticulum (ER) is extensively remodeled during metazoan open mitosis.

216 usly developed for similar purposes, that is metazoan opsins, which are light-activated G-protein-cou

217 lution, or an ancestral condition for either metazoans or eumetazoans.

218 that Orc6 is a DNA-binding subunit of human/metazoan ORC and may play roles in targeting, positionin

219 The microscopic environment inside a metazoan organism is highly crowded.

220 argest fully transgenic CRISPR screen in any metazoan organism, which further supported the high effi

221 orm a genome-wide study of epimutations in a metazoan organism.

222 ocus on effector-triggered immunity (ETI) in metazoan organisms as a mechanism for pathogen sensing a

223 Metazoan organisms rely on conserved stress response pat

224 In metazoan organisms, the discovery of growth factors and

225 between metabolism and immunity in advanced metazoan organisms.

226 homology searches, we identified MTBP as the metazoan orthologue of yeast synthetic lethal with Dpb11

227 In metazoans, pairs of co-expressed genes often reside in t

228 pressed in response to oxidative stress in a metazoan parasite, including novel antioxidant enzymes a

229 ly intra-mammalian stage of this devastating metazoan parasite.

230 asts expressing PORCN protein from different metazoan phyla, we demonstrate here that PORCN active-si

231 onents in the endoderm GRN are common across metazoan phylogeny, initiating regulatory inputs are rem

232 he presence of intracellular bacteria in the metazoan phylum Placozoa has been reported several times

233 the early eukaryotes and plays key roles in metazoan physiology.

234 Most metazoan polymerase II-transcribed genes carry canonical

235 PCR survey of eDNA in seawater using a broad metazoan primer could identify differences in community

236 However, the earliest metazoans probably needed relatively low oxygen concentr

237 w and define novel features and functions of metazoan programmed DNA elimination.

238 reconstitute Rab7 activation with yeast and metazoan proteins.

239 cific for glycine regulates the stability of metazoan proteomes.

240 quatic species represent a vast diversity of metazoans, provide humans with the most abundant animal

241 titutes the minimal channel components among metazoans, provides a framework for future mechanistic s

242 ans, it was simply one phase amongst several metazoan radiations, some older and some younger.

243 allow reconstruction of the evolution of the metazoan regulatory genome, but the deep conservation of

244 ical effects of CAT-tailing-like activity in metazoans remain unclear.

245 ellular processes in vivo and development in metazoans remains to be understood.

246 the physiological role of glucose sensing in metazoans remains unclear.

247 The 3'-end processing machinery for metazoan replication-dependent histone precursor messeng

248 an transport Ca(2+) in primitive eukaryotes, metazoans require an essential single membrane-spanning

249 Metazoans require efficient and ordered secretion of ext

250 s are coordinated across numerous introns in metazoan RNA transcripts requires quantitative analyses

251 roteins and is not related to known yeast or metazoan RNA-binding proteins or splicing regulators.

252 This is likely a conserved feature of the metazoan SAC, since the relevant PLK1 and PP2A-B56 bindi

253 biology and biochemistry, we report that the metazoan second messenger 2'3'-cGAMP induces closing of

254 ld parsimoniously explain common features of metazoan segmentation, such as changes of periods leadin

255 The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extr

256 most common DNA-binding domain expanding in metazoans since the fungi human split.

257 proposed to be a functional ortholog of the metazoan Ska complex [16, 17].

258 confirm that these are identical species one metazoan species recovered from the overlying river inte

259 se is preestablished in NHS cells of diverse metazoan species.

260 arative structural analysis demonstrates how metazoan-specific additions to the core STING scaffold e

261 (alpha-CAs) are a large and ancient group of metazoan-specific enzymes.

262 Unexpectedly, the metazoan-specific FAM32A directly bridges the 5'-exon an

263 somal modification specialized to facilitate metazoan-specific protein biogenesis at the ER.

264 also identify distinct maturation stages and metazoan-specific regulatory mechanisms involved in the

265 ails the intertwined actions of both PARN (a metazoan-specific ribonuclease) and RRP12 (a phylogeneti

266 Ubiquitin fold modifier 1 (UFM1) is a small, metazoan-specific, ubiquitin-like protein modifier that

267 In sexually reproducing metazoans, spermatogenesis is the process by which uncom

268 In metazoans, spindle assembly is a gradual process involvi

269 veral kilobases of pre-mRNA, suggesting that metazoan splicing transpires distally from the transcrip

270 oliferation and gene expression, as in other metazoan stem cells and in the proliferating stages of t

271 nserved across species, including the lowest metazoans, suggesting that it plays roles extending beyo

272 Identifying functional enhancer elements in metazoan systems is a major challenge.

273 er, whether it mediates cell adhesion in non-metazoan taxa remains unknown.

274 enriched in magnesium may be more common in metazoans than previously recognized.

275 In metazoans that developed innate immune pathways to thwar

276 roach to large-scale nuclear architecture in metazoans that incorporates cell-type-specific active pr

277 Among the broad tissue types present in metazoans, the central nervous system contains some of t

278 In several metazoans, the number of active replication origins in e

279 In metazoan tissues, cells decide their fates by sensing po

280 s grow at rates rivaling the fastest-growing metazoan tissues.

281 lly simple epitheliomuscular tissue of basal metazoans to implement a diverse behavioral output.

282 Tissue elongation is a necessary process in metazoans to implement their body plans that is not full

283 n of the D3U-box motif within dmrt1 genes of metazoans-together with preserved expression patterns of

284 iology within metazoans and the evolution of metazoan traits.

285 Metazoan transcription factors typically regulate large

286 e effect of a canonical signaling pathway on metazoan transcriptional bursting in its native context.

287 licing provides an important means to expand metazoan transcriptome diversity.

288 sis complexes differ from yeast but resemble metazoan TRAPP complexes.

289 ressing the relationships at the base of the metazoan tree of life.

290 Our analyses reveal a metazoan-typical genome architecture, with highly shared

291 and have implications for the control of the metazoan UPR.

292 The origin of extracellular digestion in metazoans was accompanied by structural and physiologica

293 ip of Relicanthus with other early-branching metazoans, we present 15 newly-sequenced sea anemone mit

294 n-type filtration system, and that the first metazoans were filter feeders.

295 NA), dissolves during prophase of mitosis in metazoans, when rDNA transcription ceases, and reforms i

296 roles in diverse developmental processes in metazoans, where it is important in driving cell fate an

297 homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes

298 -order-translation regulatory mechanism in a metazoan whereby ribosome biogenesis genes communicate w

299 Available metazoan-wide data, which are broadly discussed in the p

300 , the plant cytoplasmic homolog of yeast and metazoan XRN1, catalyzes exoribonucleolytic degradation