ライフサイエンスコーパス: methionine

1 prion protein gene: L132 (leucine) and M132 (methionine).

2 n temperature and the site of the engineered methionine.

3 o a blue copper protein by removing an axial methionine.

4 stidine target of SETD3 was substituted with methionine.

5 by methyltetrahydrofolate (CH(3)THF) to form methionine.

6 acids were present in the free form, except methionine.

7 d generates homocysteine for conversion to l-methionine.

8 ed a strong growth defect in the presence of methionine.

9 umulation and hyperaccumulate its precursor, methionine.

10 des, proteins still harboring the N-terminal methionine.

11 from the natural amino acids l-serine and l-methionine.

12 an unusually high content of the amino acid methionine.

13 , threonine and low levels of isoleucine and methionine.

14 otein bioconjugation to native or engineered methionines.

15 For S-(11)C-methyl)-l-methionine ((11)C-MET) (8 studies, 151 lesions), sensiti

16 l-l-tyrosine ((18)F-FET) and l-[methyl-(3)H]-methionine ((3)H-MET) in residual tumor after surgery an

17 fied 25 men with somatic mutations affecting methionine-41 (p.Met41) in UBA1, the major E1 enzyme tha

18 se unstacking, flipping, and melting by RAG1 methionine 848 explain how this residue activates transp

19 ecause S-adenosylmethioninamine is made from methionine, a loss of intracellular methionine leads to

20 Dose-dependent repression of methionine adenosyltransferase 1A (Mat1a), adenosylhomoc

21 Methionine adenosyltransferase alpha1 (MATalpha1, encode

22 ment of Arg-177 in PKG1alpha with alanine or methionine also increased basal activity.

23 rIIA6, to show that a host gene coding for a methionine aminopeptidase (metAP) is necessary for phage

24 KFF- EcH3, derived from the Escherichia coli methionine aminopeptidase can disrupt secondary and tert

25 ting the wide-ranging importance of the host methionine aminopeptidase in phage replication.

26 interaction with the structural core of the methionine aminopeptidase.

27 over GluN2A-containing receptors, and that a methionine and a lysine residue in the ligand binding po

28 Methionine and alanine, compounds produced in BCAA metab

29 Feeding SHC enhanced hepatic S-adenosyl-methionine and arsenic methyltransferase, whereas feedin

30 including hydroxocobalamin, methylcobalamin, methionine and betaine.

31 Dietary deficiency of the methyl-donors methionine and choline [methionine-choline-deficient (MC

32 veloping steatohepatitis upon feeding with a methionine and choline deficient diet (MCDD).

33 on the HFMCD or WDF, or to db/db mice on the methionine and choline-deficient diet, the antibodies pr

34 Sulfur compound, methionine and cysteine biosynthetic processes were iden

35 r is present in the amino acids cysteine and methionine and in a large range of essential coenzymes a

36 s vitamins B6 and B12, choline, betaine, and methionine and neural tube defect (NTD) outcomes among m

37 ed for the production of amino acids such as methionine and other biomolecules such as purines, thymi

38 echanistically, tumour cells avidly consumed methionine and outcompeted T cells for methionine by exp

39 ontrast than (18)F-fluorodeoxyglucose, (11)C-methionine and pH-insensitive (64)Cu-labelled nanopartic

40 h oxidative susceptibility owing to peptidyl methionine and proline oxidation as well as acetaldehyde

41 ary source of methyl groups, converts Hcy to methionine and reduces age-dependent cognitive decline.

42 sfer fluorescence assays demonstrated that l-methionine and S-adenosyl methionine concentrations decr

43 l control of transcripts encoding enzymes of methionine and serine metabolism, which are part of one-

44 ls, thereby lowering intracellular levels of methionine and the methyl donor S-adenosylmethionine (SA

45 Protein oxidation, with methionine and tryptophan as the most susceptible moieti

46 ly through amino acids production e.g., high methionine and tryptophan.

47 ress inducer tunicamycin or by high-fat, low-methionine, and choline-deficient (HFLMCD) diet.

48 Lysine, methionine, and cysteine usage also contribute to ROS re

49 zide-modified analogs of thymidine, uridine, methionine, and glucosamine to label nascent synthesis o

50 Mice were fed a conventional or a methionine- and choline-deficient diet or a choline-defi

51 g an integration-activated form of RAG1 with methionine at residue 848 and cryo-electron microscopy,

52 ionine transporter, in response to increased methionine availability.

53 PET scans (61%) showing less than 25% (11)C-methionine-avid tumor.

54 relate with survival outcomes, initial (11)C-methionine avidity overlapped with recurrent tumor in 10

55 (11)C-methionine avidity within MRI-defined tumor was limited

56 Here, we describe a methionine-based oxidation event involving the yeast cyt

57 provides further insight into how cells use methionine-based redox switches to sense and respond to

58 We found that methionine (beta = - 0.656, 95% CI (- 0.900, - 0.412), p

59 Accordingly, levels of methionine, betaine, and homocysteic acid were dose-depe

60 rt homoserine for downstream production of l-methionine, between IA3902 and W7, which could enable a

61 Herein we report a site-selective methionine bioconjugation protocol that uses photoexcite

62 sed intermediate in the radical S-adenosyl-L-methionine biogenesis of the M-cluster.

63 Bacterial L-methionine biosynthesis and a Ruminococcus species were

64 which could enable a secondary pathway for l-methionine biosynthesis in a W7 DeltaluxS but not in an

65 Efforts are underway to target the methionine biosynthesis pathway, as it is not part of th

66 re directly produced by a previously unknown methionine biosynthesis pathway.

67 sumed methionine and outcompeted T cells for methionine by expressing high levels of the methionine t

68 ons, including histones, is synthesized from methionine by S-adenosylmethionine synthase; inactivatio

69 emistry for highly selective modification of methionine called redox-activated chemical tagging (ReAC

70 combination of multivitamins, selenium, and methionine) can control symptoms in up to 50% of patient

71 complex regulates the expression of multiple methionine catabolic genes, including SAM synthetase (Sa

72 To further dissect the relationship between methionine catabolism and epigenetic regulation by SIN3,

73 bolism toward glycolysis, glutaminolysis and methionine catabolism.

74 ibiting peptibody L1-10 was evaluated in the methionine-choline deficient (MCD) and streptozotocin-we

75 rgets, ameliorated CXCL1/HFD-induced NASH or methionine-choline deficient diet-induced NASH in mice.

76 of the methyl-donors methionine and choline [methionine-choline-deficient (MCD) diet] is a well-estab

77 C57Bl/6 mice were subjected to a methionine-choline-deficient diet causing nonalcoholic f

78 n mice fed a high-fat diet and in mice fed a methionine-choline-deficient diet.

79 gulating phospholipid metabolism in brain of methionine-choline-deficient rats.

80 emonstrated that l-methionine and S-adenosyl methionine concentrations decreased in the W7 DeltametAB

81 Thus, cancer methionine consumption is an immune evasion mechanism, a

82 rnary structure of SETD3 in complex with the methionine-containing actin peptide at 1.9 angstrom reso

83 increases in the protein-bound cysteine and methionine content of transgenic seeds, respectively.

84 Due to its high methionine content, CaM is highly susceptible to oxidati

85 represented biochemical reactions in the (1) methionine cycle (choline: lower in AD, p = 0.003; S-ade

86 eceptor engagement controls flux through the methionine cycle and RNA and histone methylations.

87 omocysteine S-methyltransferases (BHMTs) are methionine cycle enzymes that remethylate homocysteine;

88 age-dependent strain-specific expression of methionine cycle genes in the mouse cochlea and a furthe

89 Here, we have studied the expression of methionine cycle genes in the mouse cochlea and the impa

90 uctase (MTHFR) links the folate cycle to the methionine cycle in one-carbon metabolism.

91 limiting step for protein synthesis and the methionine cycle is control of methionine transporter ex

92 units lost to polyamine biosynthesis to the methionine cycle to overcome stress.

93 ng to explore how murine T cells control the methionine cycle to produce methyl donors for protein an

94 Homocysteine, a metabolite of the methionine cycle, is a known agonist of N-methyl-d-aspar

95 e analysis revealed that both the folate and methionine cycles were affected in these mutants, as was

96 no acids (threonine, tryptophan, l-cysteine, methionine, cycloleucine, aspartic acid, asparagine, tyr

97 assembly (epsG1D) and amino acid metabolism (methionine, cysteine/arginine metabolism) in sucrose med

98 als, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme

99 S-adenosyl-l-methionine dependent methyltransferases catalyze methyl

100 a leader peptide-independent and S-adenosyl methionine-dependent O-methyltransferase that mediates t

101 These findings reveal a novel, methionine-dependent signaling and regulatory axis.

102 nd characterization of a unique S-adenosyl-l-methionine-dependent sugar 1-O-methyltransferase (MeT1)

103 ncreased reactive oxygen species, S-adenosyl-methionine depletion, global hypomethylation, induction

104 Importantly, we found that this methionine-depletion approach to polyamine depletion cou

105 mmitted step in the side chain elongation of methionine-derived aliphatic glucosinolates is catalyzed

106 er that Gcn4 protein levels are increased by methionine, despite conditions of high cell growth and t

107 Here methionine directs the conserved methyltransferase Ppm1

108 es, and stabilities of 123 single engineered methionines distributed over the surface of the antibody

109 centrations of choline chloride (CC) and D,L-methionine (DLM).

110 ich is catalyzed by the radical S-adenosyl-l-methionine enzyme AbmJ.

111 Here we address how N-terminal methionine excision (NME), a ubiquitous process crucial

112 diffusion-limited rates, allowing immediate methionine excision of optimal substrates after deformyl

113 tion of methionine transport licenses use of methionine for multiple fundamental processes that drive

114 MGDB) including folate, choline, betaine and methionine, for use in the European Prospective Investig

115 Ten (lactic acid, alanine, methionine, fumaric acid, inosine, inosine monophosphate

116 ectedly, SETD3 was active on the substituted methionine, generating S-methylmethionine in the context

117 Arginine, cysteine and methionine have Generally Recognised As Safe (GRAS) stat

118 (choline: lower in AD, p = 0.003; S-adenosyl methionine: higher in AD, p = 0.005); (2) transsulfurati

119 together with previous data from sCJDMM1-2 (methionine homozygosity at PrP gene codon 129) establish

120 oleic acid, myo-inositol, dodecanoic acid, L-methionine, hypoxanthine, palmitic acid, L-tryptophan, k

121 lows binding of the isoleucine-phenylalanine-methionine (IFM) motif to the inactivation-gate receptor

122 ns characterized by a unique substitution to methionine in histone H3 at lysine 27 (H3K27M) that resu

123 SET domain proteins to selectively methylate methionine in proteins.

124 +/- 2.7% for threonine to 98.4 +/- 1.0% for methionine in the WPI group, and from 59.3 +/- 5.6% for

125 Based on our findings, we propose that methionine influx triggers Art1 translocation to the PM,

126 cacy on a background of either MRD or normal methionine intake [regular diet (REG)] to that of MRD al

127 he background of either normal or restricted methionine intake.

128 vealed incorporation of ethionine instead of methionine into proteins, a reduction of histone-methyla

129 Instead, when methionine is abundant, Gcn4 phosphorylation is decrease

130 PP2A methylation destabilizes Gcn4 even when methionine is abundant, leading to collapse of the Gcn4-

131 osphatase 2A (PP2A); our data show that when methionine is abundant, the conserved methyltransferase

132 We also found that methionine is required for GSK3 sequestration into multi

133 Gcn4 itself is regulated in the presence of methionine is unknown.

134 Even if an internal methionine is used to produce an undetectable, N termina

135 Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone

136 tone H3 proteins that replace lysine 27 with methionine (K27M).

137 lines: one expressing H3.3K4M, a lysine-4-to-methionine (K4M) mutation of histone H3.3 that inhibits

138 and other malignancies have revealed that l-methionine (l-Met) and its metabolites play a critical r

139 To fabricate this biosensor, L-methionine (L-MET) was electropolymerized on the PGE sur

140 NMR of [(13)C(e)H(3)]methionine-labeled alpha(1A)-adrenoreceptor variants, ea

141 SAM was then cycled back to methionine, leading to futile cycles of SAM synthesis an

142 ade from methionine, a loss of intracellular methionine leads to an inability to biosynthesize spermi

143 st, which induces intracellular depletion of methionine, leucine, spermidine, and spermine, but not p

144 SERBP1 knockdown decreases methionine levels causing a subsequent reduction in hist

145 The higher oxygenation altered methionine, lipid, and purine metabolism, and inhibited

146 teria, including iron chelators, B vitamins, methionine, lycopene, squalene and polyketides.

147 phosphorylation of CHPK and that mutation to methionine (M170) results in instability of the CHPK pro

148 Choline and methionine may serve unique functions to alter hepatic e

149 ith other metabolic tracers, including (11)C-methionine, may be missed-for example, because of low he

150 involves lowering homocysteine (Hcy) with a methionine (Met)-restricted diet and betaine supplementa

151 A-B gives rise to leader peptides containing methionine (Met; M) or threonine (Thr; T), which differe

152 the aspartate residue (Asp53) of beta2M and methionine (Met93) of ESAT-6.

153 central role in the homeostasis of cochlear methionine metabolism and that Bhmt2 up-regulation could

154 lications, IL-17 signaling, and cysteine and methionine metabolism by palmitic acid.

155 Here we show that tumour cells disrupt methionine metabolism in CD8(+) T cells, thereby lowerin

156 regulate the expression of genes involved in methionine metabolism in response to SAM, primarily at t

157 ts identify a mechanistic connection between methionine metabolism, histone patterns, and T cell immu

158 Creutzfeldt-Jakob disease transmitted to 129 methionine/methionine individuals thus demonstrated no a

159 ammaproteobacteria and actinobacteria used a methionine methylation pathway independent of DsyB that

160 These bacteria contained a methionine methyltransferase gene (mmtN)-a marker for ba

161 B12, folate, total homocysteine (tHcy), methionine, MMA, metabolites of 1C metabolism (SAM, SAH)

162 In humans, a valine-to-methionine mutation (V144M) in ADAT3 that originated ~1,

163 A lysine-to-methionine mutation at lysine 27 of histone 3 (H3K27M) h

164 expressed early in infection from the second methionine of the previously annotated Copenhagen strain

165 translation at codon 54, the second in-frame methionine of the TDP2 coding sequence.

166 The methionine or homocysteine chain lies in the groove maki

167 However, the structural effects of methionine oxidation are still poorly understood.

168 We show that Fes1 undergoes reversible methionine oxidation during excessively-oxidizing cellul

169 Methionine oxidation melts Pbp1 liquid-like droplets in

170 M mutant can mimic the functional effects of methionine oxidation on CaM's regulation of the calcium

171 ed proteomics approach, based on analyses of methionine oxidation rates, to quantify stabilities of ~

172 Fifth, methionine oxidation reduces the affinity of Abeta bindi

173 For instance, enzymatic methionine oxidation regulates actin (dis-)assembly, and

174 :0 (lysoPC a C17:0, p-value = 7.1 x 10(-6)), methionine (p-value = 9.2 x 10(-5)), tyrosine (p-value =

175 and some amino acids (lysine, cysteine, and methionine; P <= .015) in differentiating between these

176 t coronary artery ligation followed by (11)C-methionine PET at 3 and 7 d (n = 3).

177 t coronary artery ligation followed by (11)C-methionine PET at 3 and 7 days (n = 3).

178 gression-free survival (P = 0.07), yet (11)C-methionine PET indices at diagnosis did not differ signi

179 Although baseline (11)C-methionine PET intensity and uniformity metrics did not

180 xtent, with 11 of 18 positive baseline (11)C-methionine PET scans (61%) showing less than 25% (11)C-m

181 oard-approved investigational study of (11)C-methionine PET.

182 d DIPGs are successfully visualized by (11)C-methionine PET.

183 maining 6 patients, both (18)F-FDG and (11)C-methionine PET/CT revealed the same number of MM lesions

184 ve MM who underwent both (18)F-FDG and (11)C-methionine PET/CT was retrospectively analyzed.

185 All patients underwent baseline (11)C-methionine PET/CT, and initial treatment-response scans

186 nges in the NMR spectra of (13)CH(3)-epsilon-methionine probes in the M2R extracellular domain, trans

187 that the genes metA and metB contribute to l-methionine production and chicken colonization by Campyl

188 ults indicate that the ability to maintain l-methionine production in vivo, conferred by metA and met

189 uence of these functions is SERBP1 impact on methionine production.

190 of Ile(310) Our results suggest that placing methionine properly in the active site-within close prox

191 Here, we evaluated whether (11)C-methionine provides further insight into heart-brain inf

192 Here, we evaluate whether (11)C-methionine provides further insights into heart-brain in

193 o steric clashes of vardenafil with a single methionine residue at position 806 in mouse PDE5A.

194 Mutational analysis demonstrates that the methionine residue at this position has a unique combina

195 Key to proton permeation is a methionine residue that interrupts the series of regular

196 s, which was attributed to the presence of a methionine residue.

197 Here, we show that the Pbp1 methionine residues are sensitive to hydrogen peroxide (

198 RGS2 contains four methionine residues close to the N terminus that can act

199 site of this oxidation to a cluster of three methionine residues in the Fes1 core domain.

200 [(13)C(e)H(3)]Methionine residues near the microswitches exhibited dis

201 itches, which consist of protein cysteine or methionine residues that become transiently oxidized whe

202 is particularly exposed to oxidation of its methionine residues, both in vivo and in vitro Oxidative

203 the alkylation also induces a conversion of methionine residues, but to the iso-threonine form.

204 airs SAA metabolism, increases resistance to methionine restriction or sorafenib, promotes epithelial

205 Methionine restriction produced therapeutic responses in

206 olled and tolerated feeding study in humans, methionine restriction resulted in effects on systemic m

207 Methionine restriction, a dietary regimen that protects

208 dictates the sensitivity of liver cancer to methionine restriction.

209 ch is mediated by vitamin B12 deficiency and methionine restriction.

210 regulates the sensitivity of liver cancer to methionine restriction.

211 In vitro translation with (35)S-labeled methionine resulted in translation of a 47 aa micropepti

212 a particular feature, this enzyme presents a methionine rich domain proposed to be involved in copper

213 ovides new insight into the copper effect in methionine rich MCOs and highlights the utility of the e

214 onstrate that substrate insertion requires a methionine-rich cytosolic loop and occurs via an enclose

215 A mutant lacking the methionine-rich hairpin domain characteristic of this la

216 eptides into a highly compliant and flexible methionine-rich loop of CueO.

217 nonical propionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle.

218 The methionine salvage pathway recycles one-carbon units los

219 Radical SAM (RS) enzymes use S-adenosyl-l-methionine (SAM) and a [4Fe-4S] cluster to initiate a br

220 me inaccessible to the cofactor S-adenosyl-l-methionine (SAM) and probably to the substrate tRNA.

221 Cysteine, S-adenosyl methionine (SAM) and the formation of an iron-sulfur clu

222 Mutations to the S-adenosyl-l-methionine (SAM) binding motif in the nsp14 abolished th

223 ules via the in situ formation of S-adenosyl methionine (SAM) cofactor analogues is described.

224 NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential for nitrogenas

225 photoproduct lyase is a radical S-adenosyl-l-methionine (SAM) enzyme with the unusual property that a

226 which is annotated as a radical S-adenosyl-l-methionine (SAM) enzyme.

227 Radical S-adenosyl-l-methionine (SAM) enzymes initiate biological radical rea

228 Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes involves electron transfer (ET)

229 number of characterized radical S-adenosyl-l-methionine (SAM) enzymes is increasing, the roles of the

230 S-adenosyl-l-methionine (SAM) is a necessary cosubstrate for numerous

231 S-Adenosyl-l-methionine (SAM) is the central cofactor in the radical

232 ation and increases intracellular S-adenosyl methionine (SAM) levels to feed epigenetic changes that

233 orescent metabolite biosensor for S-adenosyl methionine (SAM) that is expressed at low levels when ex

234 ly modulating the availability of S-adenosyl methionine (SAM), the essential metabolite for DNMT-cata

235 at Red Broccoli can be fused to a S-adenosyl methionine (SAM)-binding aptamer to generate a red fluor

236 The knot loops form the S-adenosyl-methionine (SAM)-binding pocket as well as participate i

237 S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) cata

238 strate analogue and methyl donor, S-adenosyl methionine (SAM).

239 Leucine, arginine, and methionine signal to mTORC1 through the well-characteriz

240 mune evasion mechanism, and targeting cancer methionine signalling may provide an immunotherapeutic a

241 Conclusion: PET imaging with (11)C-methionine specifically identifies an astrocyte componen

242 the SLC6A3 gene resulting in a threonine to methionine substitution at site 356 (DAT T356M) was rece

243 e glioma (DIPG) cells that carry a lysine-to-methionine substitution in histone H3 (H3K27M), but not

244 In these instances, the methionine substitution localizes to the active-site poc

245 aracterized histone SET domain proteins, the methionine substitution substantially (76-fold) increase

246 ered oncohistone mutations include lysine-to-methionine substitutions at positions 27 and 36 of histo

247 We show that methionine sulfoxide, methionine sulfone, N-formylkynurenine, kynurenine, oxin

248 Quantification of the abundant methionine sulfoxide by NMR and MS gave highly comparabl

249 presses antioxidant enzymes, among which are methionine sulfoxide reductase (Msr) enzymes, which are

250 the E. coli periplasmic molybdenum-dependent methionine sulfoxide reductase (MsrP).

251 lly, we found that a cytosolic pool of human methionine sulfoxide reductase B2 (MsrB2) is strongly re

252 liquid-like droplets in a manner reversed by methionine sulfoxide reductase enzymes.

253 versible and is regulated by the cytoplasmic methionine sulfoxide reductase Mxr1 (MsrA) and a previou

254 m Escherichia coli and the electron acceptor methionine sulfoxide reductase, also from E. coli, stron

255 s, in particular alkenal reductase PTGR1 and methionine sulfoxide reductase.

256 BC transporter solute-binding protein, and a methionine sulfoxide reductase.

257 Cd-MsrB catalyzes methionine sulfoxide reduction involving three redox-act

258 d amino acid profile and increased levels of methionine sulfoxide, an oxidative stress biomarker, in

259 We show that methionine sulfoxide, methionine sulfone, N-formylkynure

260 Moreover, methionine supplementation improved the expression of H3

261 ethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine syn

262 , function of V. cholerae cobamide-dependent methionine synthase MetH was robustly supported by cobal

263 on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofo

264 zymes that require B12, gene inactivation of methionine synthase suppressed the mitochondrial fission

265 soflavone reductase-like protein, S-adenosyl methionine synthase, and cysteine synthase isoform were

266 stream enzymes, methylmalonyl-CoA mutase and methionine synthase.

267 nctioning expression platform that regulates methionine synthesis through a previously unrecognized m

268 om the Xanthomonas campestris that regulates methionine synthesis via the met operon.

269 and B(12) -dependent MetH, respectively, for methionine synthesis.

270 s when grown in minimal medium or with added methionine, the presumed biosynthetic methyl donor.

271 sible for hepatic biosynthesis of S-adenosyl methionine, the principal methyl donor.

272 tary restriction of the essential amino acid methionine-the reduction of which has anti-ageing and an

273 e chemoselective coupling of oxaziridine and methionine thioether partners through Redox Activated Ch

274 methylation, and only a few cases of protein methionine thiomethylation have been reported.

275 Methionine, through S-adenosylmethionine, activates a mu

276 Here we systematically scanned methionines throughout one of the most popular antibody

277 in the WPI group, and from 59.3 +/- 5.6% for methionine to 69.0 +/- 5.8% for arginine in the zein gro

278 T helper cells import the amino acid methionine to synthesize new proteins and to provide the

279 the ability of l-arginine, l-cysteine and l-methionine, to inhibit postharvest senescence of broccol

280 In addition, we show that a methionine-to-arginine substitution at residue 58 impair

281 These data highlight how the regulation of methionine transport licenses use of methionine for mult

282 e deletion confirmed that (i) genes encoding methionine transporter (metP) and manganese transporter

283 hesis and the methionine cycle is control of methionine transporter expression.

284 methionine by expressing high levels of the methionine transporter SLC43A2.

285 es rapid endocytic turnover of Mup1, a yeast methionine transporter, in response to increased methion

286 Here, we report that methionine triggers rapid translocation of the ubiquitin

287 the earlier described isoleucine and formyl methionine tRNAs, and suggest that various GNAT toxins m

288 Results: (11)C-methionine uptake (percentage injected dose/cm(3)) peake

289 Results: (11)C-methionine uptake above that of uninvolved brain tissue

290 Baseline (11)C-methionine uptake delineates regions at increased risk f

291 Results: (11)C-methionine uptake peaked in the MI region at d3 (5.9+/-0

292 smission through an individual with the PRNP methionine/valine codon 129 genotype and thus no alterat

293 zfeldt-Jakob disease infection in a PRNP 129 methionine/valine heterozygous individual has raised the

294 iant Creutzfeldt-Jakob disease in a PRNP 129 methionine/valine heterozygous individual infected via b

295 nd subpassage, strain characteristics in the methionine/valine individual were totally consistent wit

296 The roles of -NH(2), -CO(2)H, and -S- of l-methionine were investigated and found critical for thei

297 : S-adenosylhomocysteine ratio and increased methionine were seen in the brain with no significant ch

298 precursors (serine, glycine, tryptophan, and methionine) were increased in cord blood compared with t

299 nethiol serves as the immediate precursor to methionine, while ethylene or methane is released into t

300 by knock-in replacement of regulatory domain methionines with valines (MMVV).