1 In summary, these
methodologic advances allow measurement of stable isotop
2 Methodologic advances as well as improved radiotracer av
3 Methodologic advances include increased use of validated
4 choriomeningitis are reviewed as are recent
methodologic advances that will facilitate the study of
5 This combination includes practical
methodologic advantages and an improved workflow facilit
6 emic response to a single food challenge and
methodologic and biological factors that potentially med
7 ses remains an important issue that may have
methodologic and clinical practice implications.
8 zed through the use of instruments measuring
methodologic and clinical quality.
9 Methodologic and conceptual advances in QOL symptom mana
10 We discuss
methodologic and conceptual problems in the study of ora
11 To this end, we provide a framework of
methodologic and data reporting standards to strengthen
12 s ethical arguments and is entrenched by the
methodologic and logistic barriers encountered with alte
13 ious Gleason score levels, which may reflect
methodologic and physiologic variations.
14 the available data is compromised by several
methodologic and statistical problems.
15 likely influential sources of bias, based on
methodologic and subject matter expertise, classifying e
16 Although
methodologic and task variations may underlie some discr
17 f findings; opportunities afforded by recent
methodologic and technologic advances in PRO data collec
18 We sought to evaluate the ethical,
methodologic,
and practical arguments for and against st
19 There was substantial clinical,
methodologic,
and statistical heterogeneity among the st
20 The
methodologic approach described here could be reproduced
21 u hybridization (FISH) represents the newest
methodologic approach for testing for this genetic alter
22 N) Project was to develop and apply a common
methodologic approach to study dietary patterns and canc
23 Our study found that applying the optimized
methodologic approach, described herein, has a high prob
24 ngle historical period, geographic location,
methodologic approach, disease spectrum, or follow-up in
25 h any large cohort study, high standards for
methodologic approaches are imperative for valid and gen
26 cellular level and highlighting the need for
methodologic approaches based on the analysis of complex
27 Methodologic approaches, results, and interpretations of
28 reviews on these topics that described novel
methodologic approaches.
29 In this
methodologic article, the extended data of a randomized,
30 s other than QALYs and review, editorial, or
methodologic articles were excluded.
31 Our findings show that some
methodologic aspects of AE collection and analysis were
32 remains a need for more research in several
methodologic aspects of design, analysis, and interpreta
33 The
methodologic attributes and efficacy of the intervention
34 g 88 eligible papers were evaluated for five
methodologic attributes.
35 nt of human PET/MR scanners; briefly discuss
methodologic challenges and opportunities provided by th
36 lorectal cancer screening, to illustrate key
methodologic challenges and suggest a framework for othe
37 Methodologic challenges associated with investigating ch
38 lone PET for treatment monitoring poses some
methodologic challenges for the quantitative analysis of
39 article provides an overview of the emerging
methodologic challenges in the cancer genome era and off
40 Consequently, and in conjunction with the
methodologic challenges inherent in studying individual
41 ogy, it is imperative that we understand the
methodologic challenges of this research and the types o
42 ment of other symptoms, identifies important
methodologic challenges that remain to be solved, and li
43 This paper reviews the
methodologic challenges that slow the research needed to
44 Among the three
methodologic challenges that still need to be solved are
45 importance, and drug resistance and describe
methodologic challenges that, if overcome, would signifi
46 However, there are epidemiologic and
methodologic challenges to accurately estimate the econo
47 This paper describes 5
methodologic challenges to performing systematic reviews
48 We also discuss recently identified
methodologic challenges to the study of knee osteoarthri
49 linical research on acupuncture poses unique
methodologic challenges.
50 The major
methodologic change resulting from the current studies i
51 Methodologic characteristics and overall data quality fo
52 The
methodologic characteristics of studies in coronary sten
53 The
methodologic characteristics of studies were extracted b
54 Due to limited availability,
methodologic complexity, and high costs, it has long bee
55 It also discusses major
methodologic concerns about the available epidemiologic
56 activities, this article first reviews broad
methodologic concerns involved in selecting measures of
57 We also discuss major
methodologic concerns regarding the available epidemiolo
58 Because of
methodologic concerns, this study was designed to examin
59 cal research findings and highlight specific
methodologic concerns.
60 There are a number of physiologic and
methodologic confounders that can affect HbA1c, but stan
61 Based on
methodologic considerations, frequencies of detection, a
62 An appreciation of
methodologic considerations, including population select
63 as high, moderate, low, or very low based on
methodologic considerations.
64 ence in either direction, largely because of
methodologic constraints such as cross-sectional study d
65 method in these subjects, and the sources of
methodologic contribution to variability of the estimate
66 This approach represents an important
methodologic contribution toward the utilization of nutr
67 in strength with increasing statistical and
methodologic controls for familial confounding.
68 matoid arthritis often fail to meet expected
methodologic criteria and therefore vary significantly i
69 Studies that met
methodologic criteria for minimal bias and had clinical
70 is may be aided by wider promulgation of the
methodologic criteria in surgical journals or at surgica
71 Compliance rates for the 5
methodologic criteria most frequently neglected ranged f
72 On a 38-point
methodologic criteria scale, the mean +/- SD score was 1
73 If a trial meets these
methodologic criteria, it must then fulfill additional c
74 and scored each based on compliance with 10
methodologic criteria.
75 story reinforces the need to understand the
methodologic derivation of statistics intended to compar
76 es of patient-reported outcomes and rigorous
methodologic designs are needed to strengthen and elucid
77 explain how systematic review can help guide
methodologic development for future research.
78 )C MRSI, emphasizing the need for further MR
methodologic development.
79 These new
methodologic developments also call for more multidiscip
80 epeatability highlights the need for further
methodologic developments before much reliance can be pl
81 Rapid
methodologic developments in mediation analyses mean tha
82 Recent
methodologic developments include computed tomography an
83 and neck cancer with a focus on research and
methodologic developments of the past year.
84 The objective was to clarify the effects of
methodologic differences between the 3 studies in estima
85 Methodologic differences did not affect HER2-to-CEP17 ra
86 There were no significant
methodologic differences in the men.
87 Methodologic differences in the quantification of levels
88 s of studies from Sweden; patient factors or
methodologic differences may contribute to differences a
89 tivity analyses investigating the effects of
methodologic differences showed no differences to the ov
90 alues in the literature, probably because of
methodologic differences, but agree with a recent study
91 To minimize interstudy
methodologic differences, we used a published real-time
92 es in ECA and NCS results are largely due to
methodologic differences.
93 trauma system effectiveness are fraught with
methodologic difficulties, several types of studies (pan
94 Median (range, IQR) quality scores for each
methodologic domain and for all included studies were co
95 Thirty-eight items distributed in 3
methodologic domains ("study design," "statistical metho
96 Biological variability and
methodologic error contribute equally to the variability
97 The contribution of
methodologic error to the observed variability in the hy
98 g findings of previous reviews resulted from
methodologic errors, highlighting the susceptibility of
99 Methodologic experts in diagnostic tests were contacted.
100 g measured may affect energy intake and is a
methodologic factor that has received little considerati
101 Several
methodologic factors and limitations among existing stud
102 The effects of these and other
methodologic factors were examined.
103 These
methodologic flaws can lead to false claims, inconsisten
104 While
methodologic flaws hamper drawing strong conclusions fro
105 The review revealed major
methodologic flaws in design, reporting and results of t
106 Despite some
methodologic flaws in the literature, psychological inte
107 for surgical patients is further limited by
methodologic flaws.
108 l, and health outcomes research to provide a
methodologic framework for assessing biologic patient su
109 This proposed
methodologic framework is intended to aid understanding
110 We introduce a new
methodologic framework to map patient proteome dynamics
111 While
methodologic guidelines for cost-effectiveness analyses
112 Given the marked
methodologic heterogeneity and the wide variety of mater
113 y of asthma ascertainment and its associated
methodologic heterogeneity have created significant barr
114 ent evidence base is plagued by considerable
methodologic heterogeneity in all aspects of study desig
115 d the included studies displayed significant
methodologic heterogeneity.
116 These results have major
methodologic implications for genome-wide methylation st
117 This paper reviews the
methodologic improvements and potential neurologic and p
118 nous samples is promising but still requires
methodologic improvements.
119 ion of this association has been obscured by
methodologic inconsistencies in the assessment of whole
120 These
methodologic innovations and discoveries underlie many o
121 with advanced skills often want training on
methodologic innovations or to practice a skill.
122 , with the discussion encompassing important
methodologic issues associated with determining clinical
123 article highlights examples of approaches to
methodologic issues associated with performing systemati
124 results from analytic studies may be due to
methodologic issues associated with study design, dietar
125 Therefore,
methodologic issues continue to be an area of ongoing di
126 before translating it into a decision rule;
methodologic issues critical to successful impact analys
127 Critical research and
methodologic issues in studying the effects of managed c
128 y has been due, at least in part, to several
methodologic issues in the study of hemostatic factors a
129 e symptoms with particular attention paid to
methodologic issues including application of theory, stu
130 its diagnostic value and clarify some of the
methodologic issues surrounding its use.
131 es key outcomes that need to be assessed and
methodologic issues that need to be addressed when condu
132 ications for neuropathic pain, but there are
methodologic issues with the available studies.
133 A number of
methodologic issues, including conditioning on an interm
134 l, the studies are confounded by a number of
methodologic issues, including the selection of an appro
135 Using a study design that addressed previous
methodologic issues, the authors evaluated personal ther
136 findings are controversial and confounded by
methodologic issues.
137 le experience has been acquired with related
methodologic issues.
138 Three important
methodologic lessons have been learned.
139 anagement of cough has evolved, looks at key
methodologic lessons that have been learned from this re
140 Because most studies had at least one
methodologic limitation, it was difficult to rigorously
141 are tempered by study heterogeneity and
methodologic limitations and a lack of trials that inclu
142 These studies had
methodologic limitations and did not differentiate among
143 All studies had important
methodologic limitations and we judged the overall quali
144 s a foundation for discussions about current
methodologic limitations and what dimensions must be inc
145 a, but the lack of a clinical definition and
methodologic limitations hamper the interpretation and c
146 associations remain inconclusive because of
methodologic limitations in dietary assessment.
147 ]) and colorectal cancer (CRC) outcomes, but
methodologic limitations including sampling selection bi
148 hese findings are consistent across studies,
methodologic limitations of a lack of a uniform or stand
149 In part, this may result from
methodologic limitations of earlier trials.
150 uclear medicine techniques and, briefly, the
methodologic limitations of sample size, frequency and t
151 The
methodologic limitations of several studies make it diff
152 ic engraftment have been inconclusive due to
methodologic limitations resulting in minimal and ineffi
153 Studies to data have important
methodologic limitations that need to be addressed in fu
154 ly derived from older studies with important
methodologic limitations) do not demonstrate a consisten
155 Methodologic limitations, however, limited interpretatio
156 ts must be interpreted with caution owing to
methodologic limitations, including a small sample size
157 s limited, and most studies are fraught with
methodologic limitations, including cross-sectional desi
158 Most trials had
methodologic limitations.
159 although many of the studies have important
methodologic limitations.
160 Studies were few and had many
methodologic limitations.
161 r, and findings are contradictory because of
methodologic limitations.
162 ceridemia was difficult to assess because of
methodologic limitations.
163 f sunscreen use have suffered from important
methodologic limitations.
164 om a relatively small number of studies with
methodologic limitations.
165 ufficient attention is paid to technical and
methodologic measurement details.
166 outcome] or not positive), and reporting of
methodologic measures whose inadequate performance may h
167 From a
methodologic perspective, interventions may be tested si
168 bservational studies, and helps avoid common
methodologic pitfalls.
169 In TRACE-CORE, sound
methodologic principles of observational studies converg
170 The standardized
methodologic principles of PRISMA for reporting systemat
171 onducted in women, however, have substantial
methodologic problems and have produced conflicting resu
172 ese modifications will also help to overcome
methodologic problems created by the lack of a reference
173 However,
methodologic problems such as lack of allocation conceal
174 These equations contain
methodologic problems that could make them inappropriate
175 rtant to emphasize, however, that because of
methodologic problems, particularly regarding sleep brux
176 Most studies are limited by
methodologic problems, such as case definition and the s
177 ythematosus (SLE) often have been limited by
methodologic problems.
178 ielded equivocal findings, partly because of
methodologic problems.
179 Methodologic progress, in particular mobilization of neu
180 m Scotland, were identified as being of high
methodologic quality according to predefined selection c
181 Adequate reporting is needed to judge
methodologic quality and assess the risk of bias of surv
182 ons (which are necessary to assess quality);
methodologic quality and clinical relevance scores; and
183 ility criteria were determined to be of high
methodologic quality and enrolled 416,159 total subjects
184 Methodologic quality and frequency of histologic abnorma
185 Studies generally had poor
methodologic quality and limited applicability to curren
186 urther classified according to indicators of
methodologic quality and other study characteristics.
187 ip negatively influences their perception of
methodologic quality and reduces their willingness to be
188 The mean
methodologic quality and relevance scores of articles we
189 Methodologic quality and risk of bias of the included st
190 heterogeneity among study samples, and poor
methodologic quality in the original studies.
191 Ongoing research of high
methodologic quality is required to consolidate and expa
192 Ts in terms of reporting the use of some key
methodologic quality measures.
193 for chronic abacterial prostatitis, and the
methodologic quality of available studies of diagnostic
194 erature: finding relevant studies, assessing
methodologic quality of diagnostic accuracy studies, and
195 Methodologic quality of each study was appraised using a
196 The
methodologic quality of each study was evaluated by usin
197 he purpose of this study was to evaluate the
methodologic quality of economic analyses of surgical pr
198 The overall
methodologic quality of existing longitudinal studies wa
199 Methodologic quality of included studies was evaluated u
200 ligibility criteria, comprehensive searches,
methodologic quality of included studies, appropriate st
201 ity Assessment Tool was used to evaluate the
methodologic quality of individual studies.
202 earch and Evaluation) was used to assess the
methodologic quality of selected guidelines.
203 The
methodologic quality of studies of diagnostic tests also
204 d quality scales or checklists to assess the
methodologic quality of the primary studies included.
205 The
methodologic quality of the small studies was generally
206 The
methodologic quality of the studies was assessed accordi
207 The
methodologic quality of the taping studies was significa
208 Methodologic quality of the trials was assessed using th
209 Methodologic quality of trials was evaluated using the u
210 The influence of
methodologic quality on relative risk for death suggests
211 nd CVD risk outcomes by using an established
methodologic quality scale.
212 quality was assessed by means of the Heyland
Methodologic Quality Score, and risk of bias was assesse
213 nd systematic reviews should not only follow
methodologic quality standards but also include more sta
214 D risk do not fully comply with contemporary
methodologic quality standards.
215 t been evaluated for satisfying contemporary
methodologic quality standards.
216 rs independently assessed the study data and
methodologic quality using data extraction and assessmen
217 rs independently assessed the study data and
methodologic quality using data extraction and assessmen
218 t reviewers assessed all included studies on
methodologic quality using QUADAS-2.
219 ing to predefined criteria and appraised for
methodologic quality using the Assessment of Multiple Sy
220 ll languages were included and evaluated for
methodologic quality using the Jadad scale.
221 Methodologic quality varied considerably among meta-anal
222 Methodologic quality varied, but 30 reviews had AMSTAR r
223 Methodologic quality varied, but few aspects of study qu
224 Their
methodologic quality was assessed by 2 judges using 2 sc
225 Methodologic quality was assessed by using Quality Asses
226 Methodologic quality was assessed by using the Quality A
227 Methodologic quality was assessed using the Quality Asse
228 Methodologic quality was assessed with AMSTAR (ie, A Mea
229 Methodologic quality was assessed, and effect sizes were
230 cles in databases through April 9, 2019, and
methodologic quality was assessed.
231 Methodologic quality was generally poor.
232 Overall
methodologic quality was high.
233 We observed that
methodologic quality was not uniform and that reproducib
234 nnel plots and the Begg and Egger tests, and
methodologic quality was rated.
235 nd Obstetrics (FIGO) stage distribution, and
methodologic quality were also collected.
236 Criteria used to assess
methodologic quality were blinding, method of allocation
237 Studies of high
methodologic quality were included in the primary analys
238 tion, data extraction, and the assessment of
methodologic quality were performed independently by the
239 ncluded studies were reviewed with regard to
methodologic quality, and study results were extracted.
240 formed to evaluate whether publication year,
methodologic quality, and/or method of evaluation (quali
241 ot associated with statistical significance,
methodologic quality, or other study characteristics.
242 ppropriate for adaptation, with most lacking
methodologic quality, particularly rigor applied during
243 collected included study characteristics and
methodologic quality, populations enrolled, intervention
244 Methodologic quality, risk of bias, and applicability co
245 For each article,
methodologic quality, size effect, the periodontal param
246 sive reporting will facilitate assessment of
methodologic quality.
247 rospective and prospective studies of varied
methodologic quality.
248 s independently extracted data and evaluated
methodologic quality.
249 Accuracy Studies 2 , tool was used to assess
methodologic quality.
250 of publication, FIGO stage distribution, or
methodologic quality.
251 ntervention; and outcomes, and also assessed
methodologic quality.
252 y was reviewed by 2 observers and graded for
methodologic quality.
253 oids for RA treatment, and many were of poor
methodologic quality.
254 growth charts for preterm infants and their
methodologic quality.
255 es of limited size (n = 7-51) but sufficient
methodologic quality.
256 uded studies (77.8%) presented a medium/high
methodologic quality.
257 ied articles to be included and assessed the
methodologic quality.
258 actual threats to scientific objectivity and
methodologic quality.
259 ery are limited in number and vary widely in
methodologic quality.
260 agents, unusual clinical manifestations, and
methodologic refinement in diagnosis and treatment.
261 genes was not known, and even after years of
methodologic refinement, more years of effort were neede
262 s are not fully corrected, thus relaxing the
methodologic requirements for obtaining noninvasive esti
263 use and impact of PROs is a growing area of
methodologic research, particularly as they relate to tu
264 f Colorectal Cancer was reviewed by ASCO for
methodologic rigor and considered for endorsement.
265 Studies were reviewed for
methodologic rigor and outcomes.
266 Additional studies with
methodologic rigor are needed for a better understanding
267 e guidance with ASCO's abiding commitment to
methodologic rigor in guideline development.
268 Lack of
methodologic rigor of the reported studies precludes any
269 The
methodologic rigor of trials investigating simulation-ba
270 ed studies were heterogeneous and lacked the
methodologic rigor to draw any conclusions regarding the
271 ASCO staff reviewed the CCO guideline for
methodologic rigor, and an ASCO panel of content experts
272 The trials had high, medium, or low
methodologic rigor, and each report included one of thre
273 effects were consistent across all levels of
methodologic rigor.
274 trials with a high, medium, or low level of
methodologic rigor.
275 g approvals, is being pressed to improve its
methodologic robustness, particularly in the light of mo
276 res ranged from 49 of 78 to 60 of 78 and the
methodologic scores from 12 of 22 to 16 of 22.
277 re evaluated for major potential biases, but
methodologic scoring was not performed.
278 ance of these findings is complicated by the
methodologic shortcomings of many studies.
279 We identified
methodologic shortcomings that contributed to these erro
280 Whereas all but one of the trials did have
methodologic shortcomings that may have allowed the intr
281 Methodologic shortcomings were identified by the adoptio
282 le variability between studies and important
methodologic shortcomings.
283 al value was considered uncertain because of
methodologic shortcomings.
284 Methodologic sources of bias in the reports by Allison e
285 shed studies followed a series of acceptable
methodologic standards and whether failure to follow the
286 cles were evaluated for adherence to minimum
methodologic standards for economic analysis research.
287 Adherence to
methodologic standards for the selection, implementation
288 Adherence to
methodologic standards in the radiology cost-effectivene
289 Failure to follow
methodologic standards may have contributed to discordan
290 We applied a published series of seven
methodologic standards to five reports of the associatio
291 met was 4.1, with 10 articles meeting all 10
methodologic standards.
292 We present and apply integrated
methodologic steps for interrogating WGS data to charact
293 Combined analyses and
methodologic studies have refined estimation of the effe
294 dose-finding trials) and statistical trials (
methodologic studies of dose-escalation designs).
295 We conducted a
methodologic systematic review to assess how organ suppo
296 eneration exhibit significant structural and
methodologic variability.
297 uniform versus nonuniform patient treatment,
methodologic variations, and correlations with other var
298 To reduce
methodologic variations, only studies reporting in the s
299 The objective of this study was to show the
methodologic weakness of comparing energy density with e
300 relationship between PFO and stroke reflects
methodologic weaknesses in studies using invalid control