ライフサイエンスコーパス: methodological

1 to these questions and clarify that RRA is a methodological advance that extends the scope of rationa

2 cribes the historical development and recent methodological advancements for studying disease classif

3 Methodological advancements in epidemiology, biostatisti

4 it substantially from recent theoretical and methodological advancements in social epidemiology that

5 This paper establishes methodological advancements relevant to glycogen metabol

6 We illustrate how four decades of methodological advances and improved data quality have f

7 review contains several formerly undisclosed methodological advances and mechanistic analyses, the la

8 lude glutamatergic alterations in psychosis, methodological advances are needed for us to investigate

9 ential of this label-free technique, crucial methodological advances are still needed.

10 urther, increases in computational power and methodological advances have made folding simulations of

11 es with their decreasing costs, coupled with methodological advances in the context of association st

12 These methodological advances led to unanticipated revelations

13 rent reserve of antibiotics and antifungals, methodological advances open additional avenues for disc

14 Methodological advances over the past two decades have p

15 Recent methodological advances permit the assessment of molecul

16 Recent methodological advances suggest that the current iTBS pr

17 chromatin are increasingly answerable due to methodological advances, enabling a needed paradigm shif

18 Here, we present methodological advances, including 4D imaging and data a

19 PRS validity is intrinsically linked to the methodological and analytical approach of the foundation

20 With these methodological and analytical improvements, in several c

21 SRH has both methodological and clinical value.

22 tes, the research community must meet robust methodological and communication standards.

23 al taxa between experimental conditions is a methodological and computational challenge.

24 o large amounts of variation; however, given methodological and data limitations, these values are li

25 es and bottlenecks that will require further methodological and hardware development.

26 , new directions for the field and important methodological and interpretative considerations that ar

27 In this article, we review methodological and practical aspects of tree-based metho

28 Methodological and reporting quality indicators were bas

29 conducted a systematic review to assess the methodological and reporting quality of antibiotic non-i

30 lated stress and health correlations, due to methodological and technical limitations, they have been

31 Methodological and technological advances in EPR spectro

32 should be interpreted cautiously because of methodological and theoretical challenges paralleling tr

33 les), the extant literature suffers from key methodological and theoretical issues.

34 on more diverse populations with consistent methodological app-roaches and objective measures.

35 The outlined methodological approach allows separation of K(+)-induce

36 We present a methodological approach assessing single-nucleotide poly

37 A commonly accepted methodological approach for detecting Rac1 activation in

38 This new instrumental and methodological approach is an important innovation that

39 We believe that our methodological approach opens the possibility to selecti

40 Here we introduce 'soft windowing', a methodological approach that selects a window of time th

41 Such morphing is problematic; the methodological approach used by the experimenter and cla

42 A multi-methodological approach, including NMR, MS, HPLC-PDA, GC

43 With this methodological approach, the results estimate what would

44 performances investigating heterogeneity of methodological approaches and data modality.

45 We outline the various methodological approaches and developments and point out

46 A full range of methodological approaches covering small to large spatia

47 oblems of external validity, specifically to methodological approaches for both quantitative generali

48 Current methodological approaches remain limited in their abilit

49 ceptual framework to link the many different methodological approaches that have been proposed for th

50 We present statistics and methodological approaches that measure low complexity (L

51 Here, we develop methodological approaches to examine local genetic influ

52 Many definitions and methodological approaches to measuring effective coverag

53 volution of these approaches, and review the methodological approaches used in SIO models so far.

54 ublished quality assessment tool, summarized methodological approaches, and conducted meta-analyses w

55 re not comparable because of their different methodological approaches, assumptions, and data used to

56 The results were robust to alternative methodological approaches.

57 nt outcomes, and leveraging a combination of methodological approaches.

58 nd the phenomenon is generally regarded as a methodological artefact.

59 red flow and/or cell orientation, leading to methodological artifacts, although direct evidence is la

60 view current technological (eg, eHealth) and methodological (artificial intelligence) advances and th

61 ikely to identify clinically meaningful HTE, methodological aspects of risk-modeling methods, conside

62 likely to identify clinically important HTE, methodological aspects of risk-modeling methods, conside

63 nd demystified with a particular emphasis on methodological aspects.

64 Study selection and methodological assessment were conducted by two independ

65 the novel technique reported here offers the methodological basis for researchers to extend the appli

66 earning and Cox regression have provided the methodological basis for this research by enabling the c

67 ity in plants, it will be essential to apply methodological best practice.

68 Methodological best practices will include external vali

69 l quality, while the associated high risk of methodological bias downgraded the evidence on the inter

70 e must rely on animal models to build strong methodological bridges for bidirectional translation to

71 lcanoes with multiple summit vents present a methodological challenge for determining vent-specific g

72 A particular methodological challenge for stable isotope labeling is

73 One methodological challenge is that it is difficult to mani

74 the mixing matrix in 65+-year-olds, and the methodological challenge of defining uncertainty on pred

75 lack biological function, presenting a major methodological challenge.

76 (FGF2) as a model system, we addressed this methodological challenge.

77 In this commentary, methodological challenges and opportunities regarding th

78 Buckley et al. highlights several important methodological challenges for research examining sex/gen

79 d in prior work, raising new theoretical and methodological challenges for the field.

80 s is scarce, likely reflecting long-standing methodological challenges in noninvasive assessments.

81 There are, however, methodological challenges in relation to adequate and un

82 for men and women, resilience to events, and methodological challenges in the literature.

83 The limited literature and methodological challenges in this field, including heter

84 In this paper, we describe the methodological challenges inherent to multigenerational

85 awake, because of the significant and unique methodological challenges involved.

86 We then argue that methodological challenges most salient to social epidemi

87 Methodological challenges must be addressed to character

88 We discuss the conceptual and methodological challenges of comparing behaviour, learni

89 Eritrea, and possibly other regions, and the methodological challenges of confirming deletion of the

90 ation analysis, while also discussing common methodological challenges that may influence the conclus

91 We identify outstanding questions and methodological challenges that need to be addressed to a

92 eir views on the most exciting and essential methodological challenges that their communities are poi

93 Addressing these practical and methodological challenges will greatly advance the exten

94 In this article we address major methodological challenges with regard to the definition

95 We encountered unanticipated methodological challenges with this trial design, which

96 However, due to methodological challenges, few studies have assessed rat

97 We highlight key methodological challenges, including new EH risk factors

98 To help solve some of these methodological challenges, we developed a new method emp

99 l-reasoning hypothesis raises conceptual and methodological challenges.

100 s studies that were affected by a variety of methodological challenges.

101 novations in model form have been limited by methodological challenges.

102 findings, it also comes with theoretical and methodological challenges.

103 f healthy child development and accompanying methodological challenges.

104 ects on stress and emotion is limited due to methodological challenges.

105 Dramatic methodological changes, designed to expand eligibility f

106 d Reynaud argue that children are not a good methodological choice to examine cumulative technologica

107 We present an application of such methodological combination for the prediction of the mel

108 the lack of certified reference materials, a methodological comparison between tandem and time-of-fli

109 enatal antidepressant safety are hindered by methodological concerns, including susceptibility to sur

110 undant TCR sequences even after exclusion of methodological confounders such as sort contamination, a

111 ancestry and admixed cohorts, we outline key methodological considerations and highlight opportunitie

112 st studies inform recommendations for future methodological considerations in this field, such as uti

113 e findings are interpreted with reference to methodological considerations including the length of th

114 initial release of the database and discuss methodological considerations to improve the success of

115 ding EJ inquiry in this context, discuss key methodological considerations, and propose a research ag

116 This methodological contribution is complemented by a statist

117 riptome has been marred by computational and methodological deficiencies.

118 f microbial cultures have been suggested, no methodological detail nor procedural guideline have been

119 eams participated to provide a comprehensive methodological development and benchmarking.

120 present the first field application of a new methodological development that allows the selective qua

121 Finally, we identify areas requiring further methodological development.

122 Methodological developments for collecting data remotely

123 Methodological developments have been driven by wide app

124 We embed all methodological developments within the framework of cond

125 This review addresses polygenic concepts, methodological developments, hypotheses, and key issues

126 Despite a great deal of general methodological developments, representing fermionic matt

127 hs and limitations of lesion studies, recent methodological developments, the integration of this app

128 However, at times this methodological device appears to morph into the substant

129 advocate for resource-rational analysis as a methodological device employed by the experimenter.

130 hs introduce resource-rational analysis as a methodological device for the empirical study of the min

131 Methodological differences across scores suggest that a

132 e extent to which effect sizes covaried with methodological differences across studies.

133 temporal change is likely caused by minimal methodological differences and partially by land-cover.

134 are identified; findings are summarized; and methodological differences and similarities among studie

135 rely adapt to them; and this is expressed in methodological differences between disciplines that comp

136 This study provides insight into methodological differences between microsatellite and SN

137 We discuss methodological differences between the Mordes and Liu st

138 our efforts to mitigate them-related to the methodological differences between these sources.

139 Despite some methodological differences in the way that the exposures

140 mapping RBP targets transcriptome-wide, but methodological differences present challenges to large-s

141 responses but remains poorly quantified with methodological differences resulting in large variations

142 We explore sampling and methodological differences to explain the variation in f

143 Due to significant methodological differences, test systems are difficult t

144 often limited due to small sample sizes and methodological differences, thus reducing the reliabilit

145 o differences in experimental data or due to methodological differences.

146 terogeneity in depression and profound study/methodological differences.

147 chiatric disorders is challenging because of methodological difficulties in analyzing human brains an

148 comprehensive overview of the reactivity and methodological diversification of metal-catalyzed peptid

149 ummarize the latest advances across multiple methodological domains including clinical phenomenology,

150 proposed, but some older studies suffer from methodological drawbacks.

151 e objective of this study was to investigate methodological explanations for the apparent attenuation

152 The proposed work sets the methodological foundation for quantifying neuronal isola

153 The lack of a robust methodological framework and of accurate data on key fac

154 We introduce a conceptual and methodological framework for applying machine learning p

155 This methodological framework for drug repurposing has broad

156 ementioned limitation by introducing a novel methodological framework for recovering rearranged cance

157 These data also provide a methodological framework for researchers to explore how

158 This study provides a methodological framework for the study of the neuroendoc

159 The Arksey and O'Malley methodological framework guided the review.

160 of migratory species, and provides a general methodological framework linking migratory energetics an

161 We present a methodological framework to evaluate confidence in the r

162 The development and application of these methodological frameworks have occurred independently fo

163 tersection-union test (SMUT) to fill in this methodological gap.

164 Methodological guidance is provided to assist consistent

165 Future reviews should adhere more closely to methodological guidelines for conducting and reporting S

166 We discuss conceptual and methodological harmonization strategies to facilitate mo

167 ts may be driven by substantial clinical and methodological heterogeneity currently affecting several

168 characteristics in clinical care and reduces methodological heterogeneity in defining phenotype, obsc

169 data on clinical remission but clinical and methodological heterogeneity precluded pooling.

170 Statistical, sample, and methodological heterogeneity was high.

171 grouped studies with sufficient clinical and methodological homogeneity, effect sizes were calculated

172 However, the methodological impact of the use of local ancestry on hi

173 Our study has important methodological implications for genetic analysis of omic

174 Methodological improvements in both single particle cryo

175 Over the past decade, technical and methodological improvements in cryogenic electron micros

176 Finally, we make the case for methodological improvements that will drive research pro

177 We show that because of methodological improvements, the human modification map

178 critical, but findings have been hindered by methodological inability to detect low-frequency subclon

179 sion pharmacology, and explore the impact of methodological innovations on AKAP research.

180 In conjunction with a series of methodological innovations, including subphase replaceme

181 Recent methodological innovations, such as improved ancient DNA

182 ference can learn from social epidemiology's methodological innovations.

183 Our work provides key methodological insights for future diet-microbiome studi

184 d an abstraction that maps commonly reported methodological instructions into discrete steps amenable

185 ficient sample size was the most predominant methodological issue (12/22) identified across reviews.

186 o, most of the available studies suffer from methodological issues and report insufficient details to

187 In this Review, we focus on four key methodological issues for future research: (1) the use o

188 asing the pace of diffusion and adoption are methodological issues in evaluation of artificial intell

189 er-degree sensitivity approach is subject to methodological issues that can generate misleading resul

190 rget exposure associations, we highlight the methodological issues, focusing on the interplay between

191 The study findings were limited by numerous methodological issues, including differences in outcome

192 of scales from leaf to ecosystem, including methodological issues, with the aim of elucidating the r

193 (2020) have addressed some of these methodological issues.

194 The main methodological limitation of this study was the relative

195 All studies had at least 1 methodological limitation.

196 However, methodological limitations (e.g. in MS of phosphopeptide

197 uthor to move beyond simply underscoring the methodological limitations and failure of the findings o

198 Although methodological limitations and potential conflicts of in

199 However, until now, technical and methodological limitations have hampered the site-specif

200 A lack of high-level evidence and methodological limitations hinder our understanding of s

201 Last, methodological limitations of fMRI can lead to spurious

202 s in global refugee populations and overcome methodological limitations of individual studies.

203 d a modeling approach that addresses several methodological limitations of prior gun policy evaluatio

204 In response to the methodological limitations of studies included in the pr

205 es, current understanding may be hampered by methodological limitations that obscure dynamic effects

206 There were significant methodological limitations within included studies.

207 risk factors for SARS-CoV-2, the studies had methodological limitations, and streamlined rapid review

208 RS-CoV-2 studies, observational studies have methodological limitations, and the review was done by u

209 Despite the identified methodological limitations, there is evidence that LGBTQ

210 on laboratory based studies with substantial methodological limitations.

211 periaqueductal gray due to technological and methodological limitations.

212 the true extent could not be assessed due to methodological limitations.

213 s prevalence data, partially attributable to methodological limitations.

214 es used in surgical studies have significant methodological limitations.

215 rarely explored due to their complexity and methodological limitations.

216 One reviewer abstracted data and assessed methodological limitations; verification was done by a s

217 heir specific systems of interest, revealing methodological links between existing applications, and

218 it relates to mechanistic understanding and methodological needs.

219 published after 2010 and had a lower risk of methodological or reporting limitations for major (P=0.0

220 pidly emerging as a promising conceptual and methodological paradigm for advancing the knowledge of t

221 This study presents a methodological pipeline for identifying influential node

222 The review also delineates methodological pitfalls and challenges.

223 an cerebrospinal fluid, establishing a novel methodological platform for biomarker analyses in Lafora

224 this article, we present guidelines for good methodological practice in functional magnetic resonance

225 Tweetable abstract: A core set of methodological principles is needed to substantially gro

226 (i) new empirical studies that address these methodological problems and largely report null results

227 We describe methodological problems with their analyses and argue th

228 The heterogeneous methodological procedures used across the studies preclu

229 a, and for facilitating both theoretical and methodological progress.

230 We illustrate the performance of our methodological proposal and compare it with earlier ABC

231 ic reporting quality (WRQ), and SMT-specific methodological quality (SMQ), respectively.

232 Methodological quality and quality of evidence of eligib

233 Despite significant variation in the methodological quality of clinical practice guidelines f

234 stracts were screened by two authors and the methodological quality of included meta-analyses was ass

235 The methodological quality of included systematic reviews wa

236 Both the reporting quality and methodological quality of SMTs still have much room for

237 udy were to assess the reporting quality and methodological quality of split-mouth trials (SMTs) publ

238 One reviewer appraised the methodological quality of the included reviews using A M

239 Methodological quality of the included studies was moder

240 The methodological quality of the included studies was rated

241 tematic Reviews 2 (AMSTAR 2) to evaluate the methodological quality of the reviews.

242 Methodological quality of these RCTs ranged from moderat

243 Methodological quality reporting was relatively low: 9%

244 When analyses were limited to good methodological quality studies, improvements in TC, HDL

245 Studies were assessed for methodological quality using a standardised assessment t

246 Each study was independently reviewed for methodological quality using the Cochrane risk of bias t

247 Methodological quality was appraised using the Appraisal

248 Methodological quality was assessed using AMSTAR-2 and J

249 The methodological quality was assessed using the Critical A

250 Study selection, methodological quality, and data extraction were perform

251 om Jan 1, 1980, to Jan 7, 2018, assessed the methodological quality, and described variations in inci

252 ractice guidelines worldwide, appraise their methodological quality, and discuss variability across g

253 ogrammes for nurses, were of low-to-moderate methodological quality, while the associated high risk o

254 mited body of evidence, which is of variable methodological quality.

255 (SRs) and identify factors that predict high methodological quality.

256 significant results and were largely weak in methodological quality.

257 quasi-experimental design but were of mixed methodological quality.

258 Methodological reasons that have hindered consensus incl

259 t specific evidence-based model selection or methodological recommendations due to lack of consistenc

260 We conclude with theoretical and methodological recommendations for future research in or

261 We provide practical methodological recommendations on how longitudinal neuro

262 This article proposes a methodological reporting framework for EHR interventions

263 t a high or unclear risk of bias due to poor methodological reporting.

264 onal web-based Delphi survey with a focus on methodological requirements for establishing benchmarks

265 Methodological restrictions led to limited evidence-base

266 However, recent conceptual and methodological revolutions have made it clear that virus

267 ever, inconsistent findings and questionable methodological rigor make drawing conclusions difficult.

268 oing so has been the wide variability in the methodological rigor of existing studies.

269 n the same year to promote a higher level of methodological rigour in studies of prognostic factors.

270 scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and res

271 usory body experiences, we conducted a multi-methodological series of experiments in a rare human amy

272 We identify key methodological shortcomings of current epidemiological r

273 of new evidence with existing meta-analyses, methodological shortcomings of studies, heterogeneity of

274 sting meta-analyses, and studies had several methodological shortcomings.

275 proteogenomic technologies, are proposed as methodological solutions that will assist the dissection

276 stematic review' label, we go on to identify methodological solutions to mitigate these pitfalls.

277 arch designs when using aDNA data and sets a methodological standard for investigating ancient mobili

278 Proper methodological standardized approaches should be impleme

279 ence suggests there is a need to improve the methodological standards and increase consistency in the

280 We also suggest methodological standards for best practices when studyin

281 From a methodological standpoint, the study explores if usage p

282 Although the methodological status of resource-rational analysis is c

283 e method developed here represents the first methodological step in an effect-directed analysis appro

284 h imaging can be obtained without additional methodological steps such as the use of contrast media.

285 We break this pursuit into key methodological steps: the selection of diagnostic sample

286 Here we present a new methodological strategy to properly and unambiguously ex

287 Methodological strengths and weaknesses are also highlig

288 The methodological studies offer a broad scope and proceed w

289 In a recent methodological study investigating the synthesis of N-al

290 We provide methodological suggestions and theoretical hypotheses to

291 te the great synthetic potential of this new methodological tool, a section is also included covering

292 ces within and across species, adding to the methodological toolkit of evo-devo studies on morphologi

293 The present work provides methodological tools and a wide empirical background to

294 Advanced technological and methodological tools provided novel insights into the ge

295 ill be achieved, in part, by employing novel methodological tools that refine the biological systems

296 relationships is undergoing a conceptual and methodological transformation due to the emergence of ne

297 ainties are typically understated; they lack methodological transparency; or they poorly integrate qu

298 Much remains to be discovered, however, as methodological variation and functional testing of stati

299 The few studies to date have significant methodological weaknesses.

300 Prior methodological work developed the joint model for longit