ライフサイエンスコーパス: methyl

1 collection of 42 novel alkyl 4-substituted-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-c

2 These aroma compounds were 3-methyl-1-butanol and eugenol, phenethyl alcohol, 2-phene

3 thyl acetate, isoamyl acetate, isobutanol, 2-methyl-1-butanol, 2-phenylethanol, E-2-hexenol, octanal,

4 he cellobiose-triazole-linked atactic poly(4-methyl-1-pentene) (CB-aPMP) sugar-polyolefin conjugate c

5 (eta(5)-C(5)Me(5))Rh((Me)PhI)H ((Me)PhI = N-methyl-1-phenylethan-1-imine) exhibited higher thermal s

6 yl) cystamine (BAC), sulfated 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and acrylic acid (

7 (11)C-UCB-J ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophen

8 CH(3)CN)](CF(3)SO(3))(2) (Me(3)NTB = tris((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amine) (1) reacts

9 at beta- and gamma-positions using 3-amino-1-methyl-1H-pyridin-2-one as an efficient, built-in bident

10 entially protected diester, 1-(tert-butyl) 4-methyl (1R,2S,4R)-2-methylcyclohexane-1,4-dicarboxylate

11 The effects of a pentacyclic triterpenoid, methyl 2-trifluoromethyl-3,11-dioxoolean-1,12-dien-30-oa

12 chloro-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxybenzamide ("ZT-1a").

13 olefin in the tether was trisubstituted (3'-methyl-2'-butenyloxy), no cycloaddition was observed.

14 the DNA (5-methyl-2'-deoxycytidine and N(6)-methyl-2'-deoxyadenosine) representing epigenetic marks,

15 ion at two different positions of the DNA (5-methyl-2'-deoxycytidine and N(6)-methyl-2'-deoxyadenosin

16 nyloxy, 2'-butenyloxy, 2'-pentenyloxy, or 2'-methyl-2'-propenyloxy group in the 2-position gave the p

17 of isoprene, 3-methyl-2(5H)-furanone, and 4-methyl-2(5H)-furanone, allowed us for the first time to

18 S(IV)-autooxidation chemistry of isoprene, 3-methyl-2(5H)-furanone, and 4-methyl-2(5H)-furanone, allo

19 anti-ketol diastereoisomers) and 3-hydroxy-3-methyl-2,4-nonanedione (HMND), prompted the investigatio

20 The formation of 3-methyl-2,4-nonanedione (MND) during red wine aging can c

21 We reveal an unusual beta-keto acid (N-methyl-2-aminobenzoylacetate) precursor that is derived

22 urinary metabolite, N-acetyl-S-(4-hydroxy-2-methyl-2-buten-1-yl)-l-cysteine (IPM3) in participants (

23 o methoxy poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (

24 were attributed to L-radicals attached to 2-methyl-2-nitrosopropane (MNP), one of three degradation

25 no-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine (1), a highly

26 to aldehydes catalyzed by metal dependent 3-methyl-2-oxobutanoate hydroxymethyltransferase from E. c

27 nsity scaling idea to an associated liquid 4-methyl-2-pentanol used as an example, we identify differ

28 )propanoic acid, DB28, as well as an analog, methyl 3-([2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]fo

29 g opening of radical cations derived from 1'-methyl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-quinoli

30 propane-1,2'-quinoline] (6) and 6'-chloro-1'-methyl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-quinoli

31 (e.g. 0.025 +/- 0.005 ng/mL for 4-hydroxy-5-methyl-3(2H)-furanone).

32 arcophagine cage amine ligand, MeCOSar (5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-yl

33 A unique lactonization of 2-methyl-3-acyl-4-phenylquinolines using PhIO as the oxida

34 )I via the linker N-succinimidyl 4-guanidino-methyl-3-iodobenzoate (SGMIB).

35 alyzed cross-coupling reaction of 1-acetyl-2-methyl-3H-pyrrolo[2,3-c]isoquinolin-5-yl triflate, easil

36 ((R)-1-((3-((11)C-methyl-(11)C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one), prev

37 6-(4-(Diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (DNMDP) is a small

38 nt picolyl amides with an allenyl sulfone, 1-methyl-4-(propa-1,2-dien-1-ylsulfonyl)benzene.

39 e pyrimidine moiety in thiamine synthesis, 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate (HMP-

40 We tested whether alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor plastic

41 endrocyte NMDARs and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in vit

42 gulation of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) abunda

43 perhaps by altering alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediat

44 he highly homologous alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor by glutamate b

45 ic, hydroxypropanoic, methyl vinyl glycolic, methyl-4-methoxy-2-hydroxybutanoic, 2,5-dihydroxypent-3-

46 l heterocyclization starting from 5-chloro-1-methyl-4-nitropyrazole and (ii) a three-step cross-coupl

47 ield potentials during normal sleep and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induce

48 nase, purine nucleoside phosphorylase, and S-methyl-5'-thioadenosine phosphorylase activity, hence, c

49 sis showed that beta ionone, benzaldehyde, 6-methyl-5-hepten-2-one, together with some acids were the

50 esis of the monomethylated FuFA, methyl 9-(3-methyl-5-pentylfuran-2-yl) nonanoate (9M5-FuFA), and its

51 of an added monomethyl furan fatty acid 9-(3-methyl-5-pentylfuran-2-yl) nonanoic acid (9M5) at 50-250

52 -(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-py

53 Methyl-7-guanosine (m(7)G) "capping" of coding and some

54 te (9M5-FuFA), and its dimethyl counterpart, methyl 9-(3,4-dimethyl-5-pentylfuran-2-yl) nonanoate (9D

55 the biosynthesis of the monomethylated FuFA, methyl 9-(3-methyl-5-pentylfuran-2-yl) nonanoate (9M5-Fu

56 on was found in ethanol, cyclopentanone, and methyl acetate; conversely, an alpha-diisobutylene and m

57 hyl group of N6-methyl deoxyadenosine and N6-methyl adenosine, epigenetic modifications of emerging i

58 a stable conjugate, installing a label at N6-methyl-adenosine.

59 MAR fully reduced 2-methyl-muconic acid to 2-methyl-adipic acid, MAR reduced only one double bond in

60 ve, while their corresponding d-enantiomers, methyl alpha-d-glucopyranoside 2,3,6-trisphosphate and m

61 ha-d-glucopyranoside 2,3,6-trisphosphate and methyl alpha-d-glucopyranoside 2,4,6-trisphosphate, are

62 l-Glucose-derived ligands, methyl alpha-l-glucopyranoside 2,3,6-trisphosphate and m

63 ha-l-glucopyranoside 2,3,6-trisphosphate and methyl alpha-l-glucopyranoside 2,4,6-trisphosphate, are

64 of principle, we employed (4,6-O-benzylidene)methyl-alpha-d-pyranosides, which provide a change in re

65 Modification of their backbone with N-methyl amides inhibits folding, which directly correlate

66 TB = tris((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amine) (1) reacts with O(2) in the presence of ba

67 ) (TPA*=tris(3,5-dimethyl-4-methoxypyridyl-2-methyl)amine) in CH(3) CN with 4 equiv CAN and 200 equiv

68 Isoprene is the 2-methyl analog of 1,3-butadiene and is a possible human c

69 Compared to their N-methyl analogues, N-trifluoromethyl azoles have a higher

70 acid and other carboxylic acids to generate methyl and alkyl radicals, respectively, without the nee

71 ctone ring associated with removal of the C2-methyl and C3-hydroxyl.

72 ould be fluorinated selectively at the gamma-methyl and methylene positions.

73 f aromatics such as benzene and toluene with methyl- and trifluoromethylamino diazonium ions were uns

74 ivators such as sulforaphane and bardoxolone methyl are already in clinical trials.

75 a Pd(II)-catalyzed coupling reaction between methyl, aryl, heteroaryl iodides, and sp(2) carbons both

76 3,4-dichloro-N-(1-(dimethylamino)cyclohexyl)methyl benzamide scaffold was studied as a template for

77 d the relevance of Z-3-hexenal, linalool and methyl benzoate as odour active compounds in feijoa arom

78 r ethyl butanoate, Z-3-hexenal, linalool and methyl benzoate responsible for the fruity, green, flowe

79 -1H-1,2,3-benzotriazol-6-yl]-1H-pyrazol-1-yl}methyl)benzonitrile (73, IC(50) = 12 nM) and 4-({5-[4-ch

80 -1H-1,2,3-benzotriazol-6-yl]-1H-pyrazol-1-yl}methyl)benzonitrile (74, IC(50) = 19 nM).

81 ring methyl, cyclopropyl methyl, cyclopentyl methyl, benzyl, phenyl, acetate, and acetamide groups, w

82 Among irreversible binders, methyl beta-(3,4-dihydroxyphenyl)-beta-(2-carboxyethyl)p

83 slow-binding and reversible kinetics, e.g., methyl beta-(3,4-dihydroxyphenyl)-beta-phosphonopropiona

84 Lipid raft/caveolae disruptors (methyl-beta-cyclodextrin (MCD) and Nystatin) and Ang II

85 res and their acute cholesterol depletion by methyl-beta-cyclodextrin as a tool to describe the physi

86 ective electrochemical oxidation of CH(4) to methyl bisulfate (CH(3)OSO(3)H) at ambient pressure and

87 ing the conventional 2,6-sulfonation to meso-methyl BODIPY photocages is incompatible with their phot

88 onate derivatives of the PAg (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBP) as well as their

89 of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by sele

90 PAgs can be microbial [(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, HMBPP] or endogenous (i

91 the nearest-neighbor nuclei, coupled to the methyl carbons, resonate in distinct frequency bands.

92 t method for converting (3-methyloxetan-3-yl)methyl carboxylic esters into 3-thiomethyltetrazines.

93 tigate four novel 4AP derivatives containing methyl (-CH(3)), methoxy (-OCH(3)) as well as trifluorom

94 thene (C(2)Cl(4)), chloroform (CHCl(3)), and methyl chloride (CH(3)Cl), are gases not regulated by th

95 plished from the common intermediate (-)-6-O-methyl-citreoisocoumarin (1).

96 Methyl-coenzyme M reductase (MCR) has been originally id

97 nnotated as two EOM and two (+)-catechin-4-O-methyl (COM) ethers.

98 rranged at higher temperatures to afford a C-methyl complex.

99 These results suggest that methyl-compounds driven methane production drives a cryp

100 thod and the two-dimensional (2D) (1)H-(13)C methyl correlation-based approach.

101 MECP2 and its product, Methyl-CpG binding protein 2 (MeCP2), are mostly known f

102 ansducin beta-like 1 X-linked receptor 1 and methyl-CpG binding protein 2.

103 scription factor binding but also to recruit methyl-CpG binding proteins that affect chromatin struct

104 In particular, the methyl-CpG-binding domain of MeCP2 shows preferential in

105 Mutations in X-linked methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome

106 With bulkier nucleophiles (ethyl/methyl cyanoacetate), the reaction proceeds with the abn

107 LuxS is essential for the activated methyl cycle and generates homocysteine for conversion t

108 as 2-pyridone-N-bearing methyl, cyclopropyl methyl, cyclopentyl methyl, benzyl, phenyl, acetate, and

109 and methoxy, as well as 2-pyridone-N-bearing methyl, cyclopropyl methyl, cyclopentyl methyl, benzyl,

110 tions to the (8-cyano-7-hydroxyquinolin-2-yl)methyl (CyHQ) chromophore to conduct an SAR study with t

111 ation of deltamethrin, penconazole, kresoxim-methyl, cyproconazole, epoxiconazole and azoxystrobin, w

112 5-methyl cytosine is widespread in plant genomes in both C

113 n excitatory neurotransmission mediated by n-methyl-d-aspartate (NMDA) receptors following stimulatio

114 N-methyl-D-aspartate (NMDA) receptors mediate synaptic exc

115 icroinjection of the glutamatergic agonist N-methyl-d-aspartate (NMDA).

116 -(-)-2-amino-5-phosphonopentanoic acid, or N-methyl-d-aspartate modulation of native or recombinant g

117 ell-signaling events were dependent on the N-methyl-d-aspartate receptor (NMDA-R) and low-density lip

118 te that antibodies from patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis alter t

119 of 7-chlorokynurenic acid (7-Cl-KYNA), an N-methyl-D-aspartate receptor (NMDAR) glycine site antagon

120 derlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and par

121 Downward FRH did not require N-methyl-D-aspartate receptor (NMDAR) signaling and was as

122 hetic doses of ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist(2,3), provide rap

123 s the rapid antidepressant efficacy of the N-methyl-D-aspartate receptor antagonist, ketamine, for tr

124 ike effects of ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, which produces r

125 69 (49%) patients and measurements of anti-N-methyl-D-aspartate receptor antibodies were taken in 49

126 itatory postsynaptic current frequency and N-methyl-D-aspartate receptor hypofunction.

127 obe for imaging the GluN2B subunits of the N-methyl-d-aspartate receptor.

128 N-methyl-D-aspartate receptors (NMDARs) are required to sh

129 Antibodies against neuronal N-methyl-D-aspartate receptors (NMDARs) in patients with a

130 N-Methyl-D-aspartate receptors (NMDARs) play critical role

131 h improved characteristics for imaging the N-methyl-d-aspartate receptors (NMDARs) subtype 2B (GluN1/

132 d no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of

133 that this effect requires open presynaptic N-methyl-d-aspartate receptors but not plasmin generation.

134 ective inhibitors of the GluN2B subunit of N-methyl-d-aspartate receptors in the ionotropic glutamate

135 nyl-butyl-tert-nitrone (alphaPBN), and the N-methyl-D-aspartic acid (NMDA) antagonist MK801-in mouse

136 orm 1 (ADAL1) to prevent incorporation of N6-methyl-(d)ATP into DNA and RNA.

137 e assessed from incorporations of deuterated methyl-D9-choline chloride.

138 to DNA in vivo, as indicated by increased N6-methyl-dA DNA levels in embryos developed from MTH1 knoc

139 ock-out zebrafish eggs microinjected with N6-methyl-dATP compared with noninjected embryos.

140 We show that N6-methyl-dATP is incorporated into DNA in vivo, as indicat

141 a C(sp(3))-H bond in the methyl group of N6-methyl deoxyadenosine and N6-methyl adenosine, epigeneti

142 ntaining fluorine, chlorine, bromine, NO(2), methyl, dimethyl, and methoxy, as well as 2-pyridone-N-b

143 he single iron site, whereas the dissociated methyl disfavors desorption into gas phase under the rea

144 ns 1 (Uhrf1) is essential for maintenance of methyl-DNA marks that stabilize Treg cellular identity b

145 Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the dev

146 g intracellular levels of methionine and the methyl donor S-adenosylmethionine (SAM) and resulting in

147 es for nsp16-nsp10 heterodimers bound to the methyl donor S-adenosylmethionine (SAM), the reaction pr

148 S-adenosylmethionine (SAM) is the methyl-donor substrate for DNA and histone methyltransfe

149 by expedite broader exploration of the magic methyl effect in pursuit of new small-molecule therapeut

150 ized this compound as an (-)-epicatechin-4-O-methyl (EOM) ether, which resulted from (-)-epicatechin

151 IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthe

152 ore, the transformation of diclofenac to its methyl ester derivative was explored in crude invertebra

153 zed cyclopropanations, and results show that methyl ester formation from a wide variety of substrates

154 ihydroxystearate, that we identified via its methyl ester through gas chromatography-mass spectrometr

155 synthase inhibitor l-N (G)-nitro-l-arginine methyl ester, while iontophoresis of the NO donor sodium

156 trus pectin (NP) was de-esterified by pectin methyl esterase to produce modified pectins [MP (42, 37,

157 (257 mg L(-1) to 547 mg L(-1)) and ethyl and methyl esters (183 mg L(-1) to 456 mg L(-1)) in comparis

158 We report the conversion of aryl methyl ethers and phenols into six fluoroalkyl analogues

159 Methyl, ethyl and (Z)-3-hexenyl benzoate with 50% of the

160 uman serum (25 muL) spiked with a mixture of methyl-, ethyl-, propyl-, and butylparaben in a concentr

161 differences in 22:0, 18:1 cis 9, and 14:0 13-methyl fatty acids (P <= 0.011).

162 findings pointed out for the first time that methyl ferulate is naturally present as bound phenol in

163 iculum Ca release, while QX-flecainide and N-methyl flecainide did not.

164 tachyarrhythmias in Casq2-/- mice, whereas N-methyl flecainide had no significant effect on arrhythmi

165 Kinetic studies on methyl fluorination suggest that the substrate and PdL a

166 ile it is likely the C-H activation step for methyl fluorination.

167 tate; conversely, an alpha-diisobutylene and methyl furan produced more soot compared to the baseline

168 cial phenomena standpoint, gallic acid (GA), methyl gallate (MG), and their combination alone and tog

169 ehyde), while 4-ethylguaiacol and trans-beta-methyl-gamma-octalactone were significantly higher in st

170 prised of patients under regular 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor

171 ts met guideline indications for 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin)

172 tween any of the H atoms of the transferring methyl group and either Met40 or Asp141.

173 d that several genes encoding key enzymes of methyl group and polyamine metabolism, including Ornithi

174 e readily observed on substrates lacking a 5-methyl group and, remarkably, TET enzymes can be similar

175 to metabolic stability, while positioning a methyl group at the C1 position of the P1' cyclopropyl r

176 tivity, and that both the ester bond and the methyl group at the gamma-position of Thr4 are crucial f

177 ted from (-)-epicatechin carbocation and the methyl group of methanol.

178 ent modification at a C(sp(3))-H bond in the methyl group of N6-methyl deoxyadenosine and N6-methyl a

179 Activation of the central methyl group of the ligand affords the diiron mu-carbyne

180 eals that when MG is in the trans state, the methyl group repels interfacial water to maintain the pl

181 Second, we showed that PTP1B (13)C-methyl group side chain fast time-scale dynamics and (15

182 with an ethyl group or adding a second 1'-N-methyl group significantly reduced interaction with alph

183 Benzylamine compounds with methyl group substitution on the charged amine or with e

184 very low subsequent transfer of this labeled methyl group to D3-PC indicated that liver PEMT activity

185 ine-4-yl-methanethiol ligand due to an extra methyl group, as compared to a more rigid 4-pyridinethio

186 investigating potential associations between methyl-group carrier intakes and risk or prognosis of ca

187 applicable for backbone amide and side chain methyl groups and represents a time and cost-effective a

188 trans-AT PKSs is their ability to introduce methyl groups at positions beta to the thiol ester in th

189 hylation states are created by deposition of methyl groups by multiple complexes of histone lysine me

190 without the enzyme that can efficiently add methyl groups de novo.

191 active allele in combination with removal of methyl groups from CpG dinucleotides.

192 widespread chemical shift perturbations for methyl groups in Z AAT (E342K).

193 amine group of lysine can accept up to three methyl groups, and experiments show that protein-protein

194 cificities (k (cat)/K (M)): propyl > ethyl > methyl > guaiacol.

195 damage and occurs independently of both O(6)-methyl guanine adduct cytotoxicity and MUTYH-dependent g

196 enantiomerically pure forms of regioisomeric methyl half esters.

197 l or safener-induced tolerance to halauxifen-methyl (HM), a postemergence (POST) wheat-selective synt

198 tempt to isolate O-benzyl-N-((trimethylsilyl)methyl)hydroxylamine.

199 Fe(phtmeimb)(2)](+) (phtmeimb = phenyltris(3-methyl-imidazolin-2-ylidene)borate) and triethylamine as

200 ic liquids cholinium hexanoate and 1-butyl-3-methyl-imidazolium acetate.

201 +/- 4.7% (decay-corrected to starting (11)C-methyl iodide).

202 eaction of the phenolic precursor with (11)C-methyl iodide, giving a radiochemical yield of 51.7% +/-

203 compared with the plant-derived JA molecule methyl jasmonate (MJ).

204 d chiral tertiary alcohols from (hetero)aryl methyl ketones is described.

205 ditions of Grignard reagents to aldehydes or methyl ketones provided no evidence for ring-opened prod

206 he interaction of aryl methyl ketones/styryl methyl ketones with selenium dioxide and malononitrile t

207 The method features the interaction of aryl methyl ketones/styryl methyl ketones with selenium dioxi

208 For S-(11)C-methyl)-l-methionine ((11)C-MET) (8 studies, 151 lesions

209 to either l-NMA or N(delta)-hydroxy-N(omega)-methyl-l-Arg (l-HMA).

210 nitrosourea moiety constructed from N(omega)-methyl-l-arginine (l-NMA) by the multi-domain metalloenz

211 shape of the catalytic pocket, while the pai-methyl-l-histidine (Pmh) moiety transfers the electrophi

212 nyl-l-histidine) and anserine (beta-alanyl-3-methyl-l-histidine) are abundant peptides in the nervous

213 ir Widom DNA molecule that is simultaneously methyl-labeled at five sites, showing that high-quality

214 tro reaction for producing NMR quantities of methyl-labeled DNA at the C5 and N6 positions of cytosin

215 an NMR-based fragment screen using selective methyl labeling.

216 led to the discovery of a peptide containing methyl lysines recognized by a mAb that binds to native

217 ethylase) of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and transiently-

218 gated whether mammalian YTH domains are also methyl mark readers of N6mA DNA.

219 methyltransferases mediating inheritance of methyl marks onto nascent DNA over cycles of replication

220 Here, we synthesized and characterized methyl (Me)- and n-butyl (nBu)-PTEs in two diastereomeri

221 alue of 1.48 per mille (+/-0.34, n = 10) for methyl-mercury in fish that feed at ~500-m depth in the

222 Methyl methacrylate is effectively polymerized by 1, wit

223 nanoparticles through the formation of poly(methyl methacrylate) (PMMA) triple-helices.

224 array was suitably interfaced with a poly- (methyl methacrylate) (PMMA) well-containing holders resu

225 polymer systems, including polystyrene, poly(methyl methacrylate), poly-L-lactic acid, polycaprolacto

226 -/-) cells treated with the alkylating agent methyl methanesulfonate (MMS).

227 y comparative study of the 1D PROFILE and 2D methyl methods on several mAbs samples to determine the

228 very of the n-butyl group as an atypical KAc methyl mimetic allowed generation of 31 (GSK6776) as a s

229 application of atypical acetyl-lysine (KAc) methyl mimetics to take advantage of the differential st

230 10) ], as well as a seven-coordinate uranium-methyl monomer, {Li(OEt(2) )Li(OEt(2) )(2) UMe(7) Li}(n)

231 nin, we found that while MAR fully reduced 2-methyl-muconic acid to 2-methyl-adipic acid, MAR reduced

232 nd (11)C-PBR28 (N-((2-(methoxy-(11)C)-phenyl)methyl)-N-(6-phenoxy-3-pyridinyl)acetamide) binds to the

233 cell lines exposed to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

234 dified arginine to N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-l-citrulline, the proposed donor

235 obtained with 10 uM 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide

236 t method has been used for deprotection of N-methyl-N-arylsulfonamides with Hantzsch ester (HE) anion

237 The unprecedented synthesis of 1-methyl naphthalenes proceeds via tandem methenylation/do

238 on a biochemical assay using the synthesized methyl neo-beta-carrabioside and the marine bacterial ex

239 ng closure approach, an S-linked analogue of methyl neo-beta-carrabioside was also realized.

240 esis-nicotinic acid adenine dinucleotide and methyl nicotinamide-were elevated in skeletal muscle aft

241 2'-O-Methyl (Nm) is a highly abundant post-transcriptional RN

242 Methyl-NMR enables atomic-resolution studies of structur

243 ent a steric clash with the side chain gamma-methyl of Val184.

244 tors of IA were change in serum ascorbate, 3-methyl-oxobutyrate, and the PTPN22 (rs2476601) polymorph

245 Nevertheless, the UV-Vis spectra of N-methyl-oxybenzi- and N-methyl-oxypyriporphyrins were dra

246 e UV-Vis spectra of N-methyl-oxybenzi- and N-methyl-oxypyriporphyrins were dramatically altered and g

247 The meC18SO was synthesized from anteiso-methyl-palmitate, in turn synthesized from a precursor m

248 ng/L with sensitivity 0.58 mA/ng/L/cm(2) for methyl parathion (MP).

249 odified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modifications.

250 bis(4-hydroxy-3-((E)-((4-hydroxyphenyl)imino)methyl) phenyl)isobenzofuran-1(3H)-one (HMBP) was design

251 andardized clinical protocol was intravenous methyl prednisolone followed by/or oral prednisolone 1 m

252 ce of 2,4,6-collidine or 2,6-di-tert-butyl-4-methyl-pyridine, the deprotonation of the initial adduct

253 using encoded library technology, with an N-methyl pyridone series identified through fragment scree

254 he amido-like structures of the N-confused N-methyl pyrrole rings of the macrocycles.

255 trimethyl orthoformate serves as a source of methyl radical via beta-scission from a tertiary radical

256 st direct experimental evidence of gas-phase methyl radicals (CH(3) (.) ) in the ODHP reaction over b

257 atter undergoing decarboxylation to generate methyl radicals.

258 he indicators studied were bromothymol blue, methyl red, and resazurin, and the reactions of each sys

259 ies, and the proton NMR spectra showed the N-methyl resonances near -3 ppm.

260 directed evolution of efficient RTs for 2'-O-methyl RNA and hexitol nucleic acids and the discovery o

261 was evaluated using two chemical simulants, methyl salicylate (MeS) and benzyl salicylate (BeS) appl

262 Xyleborus volvulus was not repelled by methyl salicylate (MeSA) or verbenone in laboratory assa

263 We assessed the repellency of methyl salicylate and verbenone to two putative laurel w

264 f Skoal Bandits Wintergreen was dominated by methyl salicylate, while Marlboro Spice consists of a mo

265 A "methyl scan" of the pyrrolidinium ring was used to detec

266 tification of the seven carbon (7-C) sugar C-methyl-scyllo-inositol (mytilitol) in mussels and clams

267 selenocysteine, selenomethionine, and seleno-methyl-selenocysteine, respectively.

268 e prostatic adenocarcinoma model through DNA methyl-Seq and RNA-Seq analyses.

269 using tert-butyl hydroperoxide (TBHP) as the methyl source, alkyl diacyl peroxides as the primary alk

270 , followed by CO insertion into the terminal methyl species.

271 rdless of the presence or absence of a 1beta-methyl substituent.

272 cleotide complexes with 5'-(R)- and 5'-(S)-C-methyl substituents attached to the 5'- and 3'-terminal

273 ther oxidation of 5mC or demethylation of N4-methyl substituents.

274 Unlike the methyl-substituted analogue, the phenyl analogue exhibit

275 ures were made possible by a self-assembled, methyl-substituted carbazole monolayer as the hole-selec

276 l analysis to show that all-syn contiguously methyl-substituted hydrocarbons, with chain lengths from

277 nes provide alpha-aryl and alpha-alkyl alpha-methyl-substituted nitriles, respectively.

278 We demonstrate the syntheses of two magic methyl substrates-an inverse agonist for the nuclear rec

279 Thus, a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines, where the pipera

280 ort the initial characterization of an ethyl methyl sulfonate-induced mutant population for the C(4)

281 itive correlation mainly with the content in methyl syringate and gallic acid.

282 e for at least seven pesticides (metsulfuron-methyl, terbutryn, imidacloprid, clothianidin, ametryn,

283 placed in organic solvents (tetrahydrofuran, methyl tert-butyl ether).

284 igher concentrations of cord UMFA, but not 5-methyl THF or total folate, were associated with a great

285 (CYP728B70) that can catalyze oxidation of a methyl to the acid moiety of dehydroabietic acid in trip

286 adical substitution reaction involved in the methyl transfer; a bromoethoxy analogue was used to expl

287 puted for transition structures (TSs) of the methyl-transfer reaction catalyzed by catechol O-methylt

288 igher expression of phosphatidylethanolamine methyl transferase (PEMT).

289 ive chromatin-modifiers such as PRC2 and DNA methyl-transferases, and proteins governing chromosome a

290 Based on a combination of methyl transverse relaxation optimized (TROSY) NMR spect

291 Methyl transverse relaxation-optimized spectroscopy (TRO

292 Moreover, 1-methyl tryptophan reduced depressive-like behavior (P <=

293 d after treatment with an immunostimulant; 1-methyl tryptophan.

294 s associated with chromatin structure around methyl-valleys.

295 ds (like glycolic, lactic, hydroxypropanoic, methyl vinyl glycolic, methyl-4-methoxy-2-hydroxybutanoi

296 Diels-Alder reaction of cyclopentadiene with methyl vinyl ketone.

297 in dark reactions, such as the reduction of methyl viologen or oxygen.

298 Replacing the 1'-N-methyl with an ethyl group or adding a second 1'-N-methy

299 enes c-[(CR(2) CH(2) )(NtBu)(2) ]Si: (R=H or methyl) with saturated backbones.

300 We studied the effect of 3-isobutyl-1-methyl-xanthine (IBMX) on THIK-1 currents.