ライフサイエンスコーパス: methylate

1 ng global de-methylation, and then become re-methylated.

2 active site, but too far away from SAM to be methylated.

3 T3-preferred CWG sites are more likely to be methylated.

4 -associated CpG island, are near-universally methylated.

5 g sites in repeat regions which are normally methylated.

6 N6-methylated adenine at box D/D' interferes with the funct

7 DNA, which illustrated that YTHDC1 binds the methylated adenine in a single-stranded region flanked b

8 s its role in conferring specificity for the methylated adenines, whereas an extended basic surface p

9 identified CpGs that remained differentially methylated after urogenital development and used the mos

10 not methylate glutamine (another potentially methylated amino acid).

11 Does the M domain methylate an amino acid residue tethered to a thiolation

12 We also synthesized N-methylated analogs of [Formula: see text] and HE which w

13 We conclude that the N-methylated analogs of HE and [Formula: see text] may be

14 Differences between the two 5'-methylated analogs of the potent pyridyl oxymethylene-br

15 diamine 1,10-phenanthroline and some of its methylated analogues as templates.

16 g BrxX and neutralizes their ability to both methylate and exclude incoming phage DNA.

17 nstrating that the endothelin axis genes are methylated and dysregulated in cancer tissue.

18 They were highly methylated and less expressed, but also overrepresented

19 ed with the oxidation of benzene and several methylated and methoxylated analogs, namely, toluene, th

20 ne-phosphate-guanine sites, which are highly methylated and result in lower KIF3A expression, and thi

21 found intact, methylated, sulfated and both methylated and sulfated quercetin sophoroside in the pla

22 We show that HMPV RNAs are m(6)A methylated and that viral m(6)A methylation promotes HMP

23 t of TFBSs and designed new tools to compare methylated and unmethylated structural profiles of TFs a

24 undant, the conserved methyltransferase Ppm1 methylates and alters the activity of the catalytic subu

25 Ts), which catalyze the formation of various methylated arginine products on a wide variety of cellul

26 croorganisms encoding active ArsM enzymes to methylate As.

27 through their efficient As(III) efflux, but methylated As poorly.

28 ycle, particularly in rice paddy soils where methylated As, generated microbially, is translocated in

29 sitive to As and capable of more efficiently methylating As.

30 CPs wrapped with either wild-type DNA or DNA methylated at all 26 CpG sites highlight the utility of

31 heterochromatic domain where nucleosomes are methylated at histone H3K9.

32 ing CG methylation are more likely to become methylated at non-CG sites and silenced.

33 rica serovar Typhimurium, FliC and FljB, are methylated at surface-exposed lysine residues by FliB.

34 or coronaviruses, RNA cap structure is first methylated at the guanine-N-7 (G-N-7) position by nonstr

35 membranes of two extensively studied Hg(II) methylating bacteria: Geobacter sulfurreducens PCA and D

36 to very long read lengths, ability to detect methylated bases, and its real-time sequencing methodolo

37 id sites, in which organic compounds, mostly methylated benzene species, are trapped.

38 ted AECs, 15 DNA regions were differentially methylated between asthmatics and non-asthmatics.

39 sis of new conformationally restrained boron-methylated BODIPY photocages that absorb light strongly

40 BREX+ cells overproducing Ocr have partially methylated BREX sites, their viability is unaffected.

41 sion protein, DNA in proximity to the POI is methylated by Dam and can be selectively digested and am

42 Cytosine DNA bases can be methylated by DNA methyltransferases and subsequently ox

43 We also found that fetal-enhancer regions methylated by Dnmt3a and Dnmt3b were enriched for kidney

44 biouptake or the ability of Hg(II) to become methylated by HgcAB and should be further explored in th

45 Moreover, pri-miRNAs are methylated by MTA, and RNA structure probing analysis re

46 Eighteen CpG sites were differentially methylated by treatment response (P < .00001).

47 neutral and alkaline pH environments and can methylate cap analogs (GpppA and GpppG) and single-nucle

48 ividual viral genes as well as synthesize 5' methylated cap and 3' poly(A) tail of the transcribed vi

49 ructures for nsp16-nsp10 in complex with the methylated Cap-0 analog m(7)GpppA and either SAM or SAH.

50 -nsp10 2'-O-methyltransferase complex, which methylates Cap-0 viral mRNAs to improve viral protein tr

51 due to degradation of mRNAs with improperly methylated caps.

52 Consequently, analysis of methylated cfDNA patterns and alternative approaches suc

53 EPR-1 associates with H3K27-methylated chromatin, and loss of EPR-1 de-represses H3K

54 mosum grown on l-carnitine, but not lactate, methylated cob-(I)alamin or tetrahydrofolate using l-car

55 Our results indicate that methylating communities dominated by diverse anaerobic m

56 ubstrates as well as the high MOG rates from methylated compounds indicated that methylotrophic metha

57 this regard, the triphosphate forms of 2'-C-methylated compounds, including sofosbuvir, approved for

58 s through the utilization of non-competitive methylated compounds; however, the occurrence and import

59 We identified 816 differentially methylated CpG positions (DMPs) and 10 differentially me

60 We identified 58 differentially methylated CpG sites associated with a subsequent breast

61 We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation

62 In the entire cohort, larger numbers of methylated CpG sites were associated with favourable out

63 Highest numbers of methylated CpG sites were found for oligodendroglioma, I

64 hen 1p19q co-deletion was absent, numbers of methylated CpG sites were higher in the presence of IDH-

65 The location of differentially methylated CpGs are predictive of both the immunosuppres

66 We identified 6 differentially methylated CpGs in Gambians [2.5-5.0% reduction in inter

67 hylation and the overlap with differentially methylated CpGs in osteoarthritis.

68 identified 956 AR-associated differentially methylated CpGs in upper airway mucosal cells at age 6 y

69 Reduced mutability around methylated CpGs is also observed in cancer genomes, cons

70 17 and identified some novel differentially methylated CpGs that are significantly associated with B

71 ormed 3 modules of correlated differentially methylated CpGs.

72 We found PRMT6 to methylate CRAF at arginine 100, interfering with its RAS

73 tion) spectra confirmed the presence of high methylated crystalline pectin in both EPP and ECP.

74 ward realizing an assay for the detection of methylated ctDNA in plasma for early cancer detection in

75 ety that is attached to the terminal carboxy-methylated cysteine, in addition to electrostatic intera

76 .4%, which are significantly higher than the methylated cytosine (mC) levels of 0.01-0.05%.

77 nscription model shows that both mono- or di-methylated cytosine bases could specify the C:T pair and

78 Methylated cytosine is an effector of epigenetic gene re

79 ated with 242, 1, 592, and 17 differentially methylated cytosine-phosphate-guanine (dmCpG) sites (fal

80 mammalian DNA is the product of oxidation of methylated cytosines (5mC) by Ten-Eleven-Translocation (

81 As a result, methylated cytosines are mutational hotspots.

82 Methylated cytosines deaminate at higher rates than unme

83 cleotides in the close vicinity (+/-3 bp) of methylated cytosines mutate less frequently.

84 (A) tracts that rotationally position highly methylated cytosines relative to phased nucleosomes.

85 n system that cleaves foreign DNA-containing methylated cytosines.

86 termediates, we synthesized a variety of C4'-methylated d-ribose and l-lyxose-configured uridine deri

87 Pathway analysis indicated that aberrantly methylated DEGs mainly associated with the P13K-AKT sign

88 Derivatives of (-)-1, i.e., the bis-methylated diamine (+)-5 and two diastereomeric tricycli

89 horts profile datasets to ascertain aberrant methylated-differentially expressed genes and pathways a

90 ze, we have identified six feasible aberrant methylated-differentially expressed genes and pathways i

91 esent study, we detected and quantified 16-O-methylated diterpenes (16-OMD) in 248 samples of green C

92 reviously unknown pathway intermediate was a methylated diunsaturated fatty acid, (10E,12E)-11-methyl

93 Inference of differentially methylated (DM) CpG sites between two groups of tumor sa

94 ckdown resulted in over 8,000 differentially methylated (DM) CpGs, treatment with the ERK1/2-selectiv

95 Differentially methylated (DM) loci in motile sperm were identified usi

96 tegrative network analysis of differentially methylated (DMGs) and differentially expressed genes (DE

97 Two hypo-methylated DMPs, namely cg13986138 (CYFIP1) and cg103165

98 available methyltransferases to specifically methylate DNA at a desired number of sites that serve as

99 Given the physical stability of DNA and methylated DNA compared with other epigenetic modificati

100 Cell-free methylated DNA immunoprecipitation and high-throughput s

101 Interaction between MeCP2 and methylated DNA in the regulation of gene expression is w

102 is also reported to have an affinity for non-methylated DNA sequences.

103 TgDelta185) both alone and in complex with a methylated DNA substrate at 1.68 and 2.27 angstrom resol

104 for standard DNA and four shape features for methylated DNA.

105 to in vivo binding and from unmethylated to methylated DNA.

106 preformed DNMT3A:DNMT3L complex was actively methylating DNA.

107 tested if DNMT3A Arg882His could preferably methylate DNMT3B-specific target sites in vivo.

108 ls prior to global de-methylation, become de-methylated during global de-methylation, and then become

109 by histone marks H3K4me1 and H3K27ac were de-methylated during in vitro chondrogenesis.

110 Recombinant MtcB methylates either cob(I)alamin or Co(I)-MtqC in the pres

111 hypermethylated promoters in constitutively methylated ESCs.

112 We synthesized N-methylated flecainide analogues (QX-flecainide and N-met

113 Mechanistically, we reveal that PRMT1 methylates Fms-like receptor tyrosine kinase 3 (FLT3) at

114 Methylated forms of Clark I/II, Adamsite, and phenyldich

115 This homogeneously methylated fraction of histone H3 in the sperm genome is

116 a gross total resection (GTR), MGMT promoter-methylated gene status, unifocal disease, higher RT dose

117 Aberrant methylated genes (DMGs) play an important role in the et

118 identified 497 differentially expressed and methylated genes (P = 6.42e-09, hypergeometric test) enr

119 Differentially expressed and methylated genes and methylation quantitative trait loci

120 et of inflammation-associated differentially methylated genes in both AD and PSO and discuss the asso

121 Our analysis identified differentially methylated genes such as MAMSTR, AGAP2, and AZU1.

122 omatin, and loss of EPR-1 de-represses H3K27-methylated genes without loss of H3K27 methylation.

123 Differentially expressed and/or methylated genes, including RPS27L, were associated with

124 dDM-dependent, involving 1380 differentially methylated genes, many within auxin-related gene pathway

125 nts, and a prevalence of methylated over non-methylated genes.

126 atistical method to determine differentially methylated genes.

127 aring two exclusively but equally CG- or CHG-methylated genomes, we show that CHG methylation acts as

128 s primary melanoma and detection in serum of methylated genomic DNA from the AGTR1 CpG island in meta

129 10 muM concentration, particularly the per-O-methylated glucosylacetophloroglucinol and the 4-glucosy

130 ccurred in body fluids mainly in the form of methylated, glucuronidated, and sulfated derivatives (in

131 its Asn(255) substituted derivatives did not methylate glutamine (another potentially methylated amin

132 ignificance of its reported affinity for non-methylated GT-rich sequences.

133 l modifications at their 5' end: an inverted methylated guanosine and a unique 2'O-methylation on the

134 ubiquitin on one face of the nucleosome and methylating H3 on the opposing face.

135 e that the histone methyltransferase SET-32, methylates H3K23 in vitro.

136 he Polycomb Repressive complex 2 (PRC2) that methylates H3K27, switches the gene into an active chrom

137 hat permits allosteric inhibition of PRC2 by methylated H3K36 in transcriptionally active chromatin.

138 transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2.

139 x-protein core COMPASS subcomplex, which can methylate H3K4 and be stimulated by H2B-Ub, bound to a u

140 ckpoint-defective cells, and the presence of methylated H3K4 slows down ongoing replication.

141 MLL2/COMPASS methylates H3K4 on many developmental genes and bivalent

142 , our results suggest that each KMT2 complex methylates H3K4 through distinct mechanisms in which ind

143 Additionally, we identified differentially methylated H3K4me1 peaks in basal and luminal tumour sam

144 ogenic genes to function as a coactivator by methylating H3K79.

145 Such methylated histone fraction resisting post-fertilisation

146 g spermiogenesis results in the retention of methylated histone H3 at the same genomic location in mo

147 A similar homogeneously methylated histone H3 fraction is detected in human sper

148 embryo through the homogeneous retention of methylated histone in a sperm cells population.

149 -quality chromatin profiles particularly for methylated histone marks but is not optimized for H3K27a

150 2 (PRC2) is a histone methyltransferase that methylates histone H3 at Lysine 27.

151 associations with features such as H3 Lys-27 methylated histones (H3K27me3) and accessible DNA.

152 ion of chromosome 11, known to be abnormally methylated in another disorder of expanded beta cell mas

153 All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 wer

154 omoters of inactive genes are differentially methylated in both syndromes while escape gene promoters

155 bsets of putative somatic enhancers that are methylated in ESCs and can be activated upon differentia

156 o show that half of the TEs that were highly methylated in gametes had already undergone CHH hypermet

157 es, located in 99 genes, were differentially methylated in islets of humans with T2D.

158 show that KIR proximal promoters are densely methylated in less mature CD56(bright) NK cells and are

159 he majority of sequences were differentially methylated in MCF7 (cancerous) and MCF10A (non-cancerous

160 Because KIR genes are densely methylated in NK cell progenitors, there is an implied s

161 The HRE of EGFR was methylated in normal breast tissue and some breast cance

162 HTR2A is differentially methylated in progressive MS independent of genotype.

163 , a subset of arginine tRNA isoacceptors are methylated in the anticodon loop by the METTL2 methyltra

164 HIFs fail to bind CpG dinucleotides that are methylated in their consensus binding sequence, both in

165 Using a repertoire of murine variably methylated intracisternal A-particle (VM-IAP) epialleles

166 assays and in vivo studies of differentially methylated isogenic cell lines.

167 , i.e. while localized in the ER, Opi3 would methylate lipid substrates located in the plasma membran

168 In conclusion, we identified and replicated methylated loci associated with MDD that are involved in

169 A total of 373 differentially methylated loci comprising these networks are sufficient

170 focal demethylation at thousands of normally methylated loci.

171 epresses nascent RNA transcription of highly methylated long genes in the brain through its interacti

172 ich Pol II initiates transcription of highly methylated long genes.

173 ferential binding to histone H3 tails with a methylated lysine at the ninth residue, a hallmark of he

174 The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is involved

175 DOT1L methylates lysine 79 in the globular domain of histone H

176 ription factors in pluripotent stem cells by methylating lysine 27 on histone H3.

177 This double-methylated m42C also results in the loss of base pairing

178 .4% of cytosines in Saccharina japonica were methylated mainly at CHH sites and characterized by 5-me

179 mouse DNMT3A severely impairs its ability to methylate major satellite DNA, a DNMT3A-preferred target

180 The mechanisms by which methylated mammalian promoters are transcriptionally sil

181 e microorganisms differ in their capacity to methylate mercury, the abundance and distribution of met

182 Profiles for iAs and its methylated metabolites in tissues and excreta of the hum

183 Therefore, potentially methylated metabolites of polar contaminants should be c

184 llow some SET domain proteins to selectively methylate methionine in proteins.

185 t, but has no overt effect on the ability to methylate minor satellite DNA, a DNMT3B-preferred target

186 Compared to non-methylated miR-21-5p, methylated miR-21-5p is more resistant to digestion by 3

187 Compared to non-methylated miR-21-5p, methylated miR-21-5p is more resis

188 Further, we found that MeCP2 binding to methylated miRNA loci halts RNA polymerase II elongation

189 cal motif of the TF and the newly discovered methylated motifs, which suggests operative recognition

190 engineering of NRPS to generate unnaturally methylated NRPs.

191 ominance occurs even when DNMT3A is actively methylating nucleosome substrates.

192 also sanitize the nucleotide pool from other methylated nucleotides.

193 ches, we present the single-molecule adenine methylated oligonucleosome sequencing assay (SAMOSA).

194 ESCs with three epitypes, WT, constitutively methylated, or hypomethylated, all undergo comparable mo

195 The metabolic activity of methylating organisms is highly dependent on biogeochemi

196 d transposable elements, and a prevalence of methylated over non-methylated genes.

197 ocally demonstrated that the wild-type AMATs methylate overwhelmingly in cis, strongly suggesting tha

198 We synthesized a library of N-methylated peptides derived from MLPs and conducted stru

199 es (PLMTs) synthesize phosphatidylcholine by methylating phosphatidylethanolamine using S-adenosylmet

200 odeling factor under glucose starvation, and methylated Pontin binds Forkhead Box O 3a (FOXO3a).

201 analyses and biochemical studies reveal that methylated Pontin functions as a platform for recruiting

202 ociated arginine methyltransferase 1 (CARM1) methylates Pontin chromatin-remodeling factor under gluc

203 e mercury, the abundance and distribution of methylating populations may determine MeHg production in

204 emented linear models to test differentially methylated positions (DMPs) and the DMRcate method to id

205 ted level of 0.05, we found 6 differentially methylated positions (DMPs) for Cd; 288 and 17, respecti

206 not identify any significant differentially methylated positions (DMPs) in singleton pregnancies, in

207 has been done in associating differentially methylated positions (DMPs) to type 2 diabetes (T2D) acr

208 Differentially methylated positions (DMPs) were evaluated at a false di

209 From these studies, 380 differentially methylated positions (DMPs), located throughout the geno

210 Differentially methylated positions and regions (DMPs and DMRs) were id

211 acetyl (MIDA) acylboronates as well as alpha-methylated potassium acyltrifluoroborates in a one-pot m

212 Chromatin states were differentially methylated, promoters were less methylated than represse

213 use of a mildly nucleophilic organoaluminium methylating reagent that preserves other electrophilic f

214 onseptic patients, 81% of the differentially methylated region-associated genes were differentially e

215 any context, but thousands of differentially methylated regions (DMRs) are identified population-wide

216 d CpG positions (DMPs) and 10 differentially methylated regions (DMRs) associated with asthma severit

217 are also enriched for common differentially methylated regions (DMRs) in CRC.

218 nt establishment of imprinted differentially methylated regions (DMRs) in gametes or their maintenanc

219 althy controls and identified differentially methylated regions (DMRs) in HLA-DRB1 and RNF39.

220 phate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to 1-y average air

221 identified 3751 CpGs and 119 differentially methylated regions (DMRs) significantly associated with

222 990 early-postpartum-specific differentially methylated regions (DMRs) were found in genes involved i

223 compared with WT, and 20 556 differentially methylated regions (DMRs) were identified by comparing t

224 scovery rate (FDR) < 0.05 and differentially methylated regions (DMRs) were identified using comb-p (

225 ably, we identify a cohort of differentially methylated regions (DMRs), most of which gain DNA methyl

226 cific preeclampsia-associated differentially methylated regions among singletons.

227 tation sequencing (MeRIP-seq), through which methylated regions are detected as peaks in transcript c

228 Hypo-methylated regions are enriched in areas with heterochro

229 ing markers (H3K9me3, H3K27me3), while hyper-methylated regions are enriched in polycomb repressive c

230 ed sites and four times fewer differentially methylated regions compared to samples from different pa

231 A total of 668 differentially methylated regions corresponding to 443 genes were ident

232 y expressed genes (DEGs) with differentially methylated regions encoding transcription factors and ke

233 lation but also by opening up previously CpG methylated regions for PRC2 recruitment, diluting PRC2 a

234 ghly ordered, suggesting that differentially methylated regions have unique properties that may be re

235 esults show that a network of differentially methylated regions in glucocorticoid signaling and infla

236 Differentially methylated regions in N-ERD macrophages included genes i

237 among ASM loci, but most ASM differentially methylated regions lack such annotations, and some are f

238 n in which MeCP2 binds broadly across highly methylated regions of DNA, but acts at transcription sta

239 ritable and novel nonparental differentially methylated regions overlapping with genes associated wit

240 ession is complex, with three differentially methylated regions regulating germline, placental and ti

241 of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans

242 Differently methylated regions were defined as at least two consecut

243 n silico analysis showed that differentially methylated regions were enriched in transcription factor

244 spanning multiple CpG sites (differentially methylated regions).

245 ostly orthogonal to classical differentially methylated regions, are enriched at cell type-specific e

246 nt 15,112 high-confidence ASM differentially methylated regions, of which 1838 contain SNPs in strong

247 ables identification of novel differentially methylated regions, which we independently validate.

248 g noncoding RNA genes were the most strongly methylated regulatory elements in S. japonica.

249 Finally, we observe that TGCT-methylated repeats are specifically associated with H3K9

250 ential for the transcriptional repression of methylated retrotransposons.

251 PEDV nsp14 can efficiently methylate RNA substrates with various lengths in both ne

252 monly found in eukaryotic proteins that bind methylated RNA and is structurally unrelated to the E. c

253 of this approach by reversibly caging a 2'-O-methylated RNA aptamer as well as synthetic threose nucl

254 edict changes in m(6)A between conditions is methylated RNA immunoprecipitation sequencing (MeRIP-seq

255 ethyltransferase (G-N-7 MTase) of PEDV nsp14 methylated RNA substrates in a sequence-unspecific manne

256 eviously shown to bind a lysine and arginine methylated sequence of histone H3.

257 Here, we show that H1 is enriched in methylated sequences, including genes, of Arabidopsis th

258 example, tedizolid) and natural products-are methylated site-selectively at the most electron rich, l

259 Differentially methylated sites (DMSs) with GC exposure clustered into

260 We sought to identify differentially methylated sites and affiliated genes in pre-treatment o

261 the same patriline had twice as many shared methylated sites and four times fewer differentially met

262 of the water+H(2)O(2) extractable arsenic as methylated species, but only dimethylarsinate showed a c

263 easured in urine as the sum of inorganic and methylated species.

264 While methylated spirits are already a known pro-oxidant, thes

265 a hemolytic phenotype versus control, while methylated spirits showed a 39.7% increase in affected p

266 the newborn umbilical cord: eucalyptus oil, methylated spirits, and Yoruba herbal tea.

267 ter effect biases binding in favor of higher methylated states.

268 This biases binding toward lower methylated states.

269 encoded protein A061L, which requires an O-2 methylated substrate.

270 whether it is an active enzyme that directly methylates substrate(s) in vivo is unclear.

271 The ability to methylate such complex molecules at late stages will red

272 g an in situ rat gut model, we found intact, methylated, sulfated and both methylated and sulfated qu

273 is study, we provide evidence of a bacterial methylated T cell peptide epitope.

274 show that in sweet almond cultivars, highly methylated TE insertions surround a gene involved in the

275 Recombinant MtcB, MtqC, and MtqA methylated tetrahydrofolate via l-carnitine, forming a k

276 TFs) from the JASPAR and UniPROBE databases, methylated TFBSs derived from in vitro high-throughput E

277 hput EpiSELEX-seq binding assays and in vivo methylated TFBSs from the MeDReaders database.

278 donor genes mapped more siRNAs and were more methylated than genes with no evidence of capture.

279 fferentially methylated, promoters were less methylated than repressed regions (P<2x10(-16)).

280 mapped fewer siRNAs, and were slightly less methylated than TEs without captured fragments.

281 One strategy to precisely methylate the 2' oxygen is to use viral mRNA methyltrans

282 rotein N-terminal methyltransferases (NTMTs) methylate the alpha-N-terminal amines of proteins starti

283 eferentially bind to nucleosomes, yet cannot methylate the DNA wrapped around the nucleosome core(2),

284 tly catalyze tRNA methylation, is assumed to methylate the genome of S. japonica in the structural co

285 anscription factor complex that bound to and methylated the CAV1 promoter, leading to CAV1 expression

286 otein 16 (nsp16), in conjunction with nsp10, methylates the 5'-end of virally encoded mRNAs to mimic

287 on, and domain 3 is a methyltransferase that methylates the C-2 hydroxyl group of the terminal alpha-

288 ctivity of BioC, an O-methyltransferase that methylates the free carboxyl of malonyl-ACP.

289 tch from the SWI/SNF complex to EZH2 through methylating the BAF155 subunit of the SWI/SNF complex on

290 In flooded paddy soils, inorganic and methylated thioarsenates contribute substantially to ars

291 ain on same NRPS module (in cis), or does it methylate this residue on a nascent peptide tethered to

292 eucine and proline being the most frequently methylated tRNA isoacceptors, loss of m(5) C impacts the

293 25 (44.6%) patients had MGMT hyper-methylated tumors, 6 (10.7%) were IDH1 mutated.

294 nstability was observed within MGMT promoter-methylated tumors.

295 uanine-DNA methyltransferase (MGMT) promoter methylated tumors.

296 f the NILs were substantially differentially methylated under uninfected conditions.

297 in muscle biology that has been reported to methylate valosin-containing protein/p97 (VCP) and heat

298 thyltransferase assay revealed that Mettl21e methylated valosin-containing protein (Vcp/p97), a key c

299 tive genes were significantly differentially methylated versus controls.

300 sites were also significantly differentially methylated with allergic symptoms and shared between ast