ライフサイエンスコーパス: methylene

1 e, Apiol, 1,6-Cyclodecodiene, and 1-methyl-5-methylene.

2 ethide intermediates are also observed for 3-methylene-1,2,4-naphthotriones, such as small endo/exo d

3 lic ketene acetals, specifically 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), results in well-defined,

4 olymers can uniquely be copolymerized with 2-methylene-1,3-dioxepane (MDO) to generate polymers in wh

5 sis of 3-[(4-nitrophenyl)thio]-substituted 4-methylene-1-pyrrolines is described.

6 2-[(2H-Indazol-3-yl)methylene]-1H-indene-1,3(2H)-dione 6 and (E)-2-[(2H-inda

7 tor ITCC (3,9-bis(4-(1,1-dicyanomethylene)-3-methylene-2-oxo-cyclopenta[b]thiophen)-5,5,11 ,11-tetrak

8 -1,3(2H)-dione 6 and (E)-2-[(2H-indazol-3-yl)methylene]-2,3-dihydro-1H-inden-1-one 7 have been synthe

9 (Z)-2-((2-((1-ethyl-5-methoxy-1H-indol-3-yl)methylene)-3-oxo-2,3-dihydrobenzofuran-6-yl)oxy)acetonit

10 thane as the solvent, at room temperature, 4-methylene-3-(organoselanyl)-selenochromenes were formed

11 (III) chloride leading to the formation of 4-methylene-3-(organoselanyl)-selenochromenes.

12 derwent nucleophilic cyclization to afford 4-methylene-3-[(4-nitrophenyl)thio]-1-pyrrolines in good t

13 RIMA-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (MQ), can restore unfolded p5

14 assy amorphous matrix based on a perfluoro(2-methylene-4-methyl-1,3-dioxolane) (PFMMD) backbone.

15 ons, namely Wittig reactions, reactions with methylene active compounds, formation of amines, amides,

16 ion of methyl coumalate with a wide range of methylene active compounds, such as keto-esters or keto-

17 tructures of SMPDL3A with AMP and alpha,beta-methylene ADP (AMPCP) reveal that the substrate binding

18 Inhibition of CD73 by alpha,beta-methylene ADP (AOPCP) in the whole CB preparation in vit

19 of the competitive CD73 inhibitor alpha,beta-methylene-ADP (AOPCP) substituted in the 2-position.

20 CD73 mRNA, and alphabeta-methylene-ADP-inhibitable ecto-AMPase activity were elev

21 Substitution at the level of the side chain methylene afforded compounds targeting specifically and

22 tibodies has been developed and involves the methylene alkoxy carbamate (MAC) self-immolative unit.

23 could be exploited to access 2-aryl/alkenyl-methylene-alpha-glucopyranoside scaffolds via a three-st

24 -bis(diethylamino)-2-{[(1E)-(4-ethoxyphenyl) methylene] amino}spiro[isoindole-1,9'-xanthen]-3(2H)-one

25 ol, and a Schiff-base (2-[[(2-hydroxyphenyl) methylene]amino]-1,3-propanediol) forms a block copolyme

26 diethylamino)-2-{[(1E)-(4,5-dimethyl-2-furyl)methylene]amino}spiro[isoindole-1,9'-xanthen]-3(2H)-one

27 eported for a cyclohexane featuring opposing methylene and a vinylidene fragments.

28 ubbs olefin metathesis-mediated synthesis of methylene and difluoromethylene monophosphonate derivati

29 he ring test spectral ensemble that contains methylene and methyl peaks (1.4-0.6 ppm) showed that 97.

30 two trimethylstannyl units, one linked by a methylene and the other by an ethylene group.

31 le frameworks from 3-formylchromones, active methylenes, and alpha-azido ketones using piperidine as

32 hat intrapericardial injection of alpha,beta-methylene ATP (alpha,beta-meATP, P2X receptor agonist),

33 The P2X receptor agonist alpha,beta-methylene ATP (alpha,beta-meATP; 10 muM) evoked rapidly

34 to static muscle contraction and alpha,beta-methylene ATP (alphabeta-me ATP, a P2X agonist) was exam

35 esic markers capsaicin, AITC and alpha, beta-methylene ATP.

36 ] ring expansion to yield highly substituted methylene azetidines with excellent regio- and stereosel

37 where the unique strain and structure of the methylene aziridine promotes a ring-opening/ring-closing

38 onverted into azetidine derivatives, whereas methylene aziridines are the products resulting from alk

39 Methylene aziridines from alkylallenes derive from catal

40 hodium-bound carbenes with strained bicyclic methylene aziridines results in a formal [3+1] ring expa

41 NI through free radical polymerization using methylene bis-acrylamide, and ammonium persulphate as th

42 osomal delivery of a metabolically resistant methylene bisphosphonate (PCP) analog of InsP(8); PCP an

43 Methylene blue (4 muM) irradiated with red light (660 nm

44 ed when Methylene Blue was combined with New Methylene Blue (Combination Index = 0.84).

45 (MB), New Methylene Blue (NMB), 1,9-Dimethyl Methylene Blue (DMMB) and Toluidine Blue O (TBO) on N. c

46 ecule with its cavities matching the size of methylene blue (MB(+)), a versatile organic molecule use

47 Furthermore, 1 can enrich methylene blue (MB) and can also serve as an effective a

48 NA biosensor is developed based on employing methylene blue (MB) as a redox indicator.

49 Using methylene blue (MB) as an electrochemical probe and diff

50 us DNA sequence of Dengue virus (DENV) using methylene blue (MB) as an intercalating agent.

51 UV/H(2)O(2) as the (*)OH generation system, methylene blue (MB) as the probe compound, and isopropyl

52 he nanoprobes, i.e. the electroactive marker methylene blue (MB) encapsulated within nanometer-sized

53 We studied the inhibitory activity of methylene blue (MB) gamma-carbolines (gC) conjugates (MB

54 gs through a case study of the conversion of methylene blue (MB) into a reduced MB ion radical on the

55 that the fluorescence polarization (Fpol) of Methylene Blue (MB) is significantly higher in cancer th

56 Among these derivatives, methylene blue (MB) possesses high reversibility with ex

57 rapid biorecognition of carrageenan by using methylene blue (MB) redox indicator.

58 knesses and pore morphologies coupled with a methylene blue (MB) reporter-tagged DNA probe for DNA ta

59 ocessed graphene oxide nanoribbon (GONR) for methylene blue (MB) sensing.

60 ht source, the estimated detection limit for methylene blue (MB) was 30 nM, corresponding to 120 amol

61 tabilized gold nanoparticles (PLA-AuNPs) and methylene blue (MB) was employed as the redox indicator

62 Subsequently, methylene blue (MB) was immobilized into the aptamer as

63 reactor (FBR) for the treatment of simulated methylene blue (MB) wastewater for 9 weeks under aerobic

64 applied in an adsorption column, to pretreat methylene blue (MB) wastewater with high concentration (

65 ed by interaction of anionic mediator, i.e., methylene blue (MB) with free guanine (3'G) of ssDNA.

66 tion in current, generated by interaction of methylene blue (MB) with free guanine (3'G) of ssDNA.

67 Methylene blue (MB), a phenothiazine dye that crosses th

68 Methylene blue (MB), a traditional mitochondrial-targeti

69 ation (in high yields) of New Fuchsine (NF), Methylene Blue (MB), Erythrosine B (ER) and 4-chlorophen

70 a unique competitive detection scheme using methylene blue (MB), hydrazine and platinum nanoparticle

71 anti-parasitic effects of the phenothiaziums Methylene Blue (MB), New Methylene Blue (NMB), 1,9-Dimet

72 zed oxidation of leucomethylene blue (LB) to methylene blue (MB), the redox label conjugated to the a

73 latin sensor fabricated with a thiolated and methylene blue (MB)-modified oligo-adenine (A)-guanine (

74 formation of these complexes rigidifies the methylene blue (MB)-modified oligoadenine probes, result

75 ne reductase inhibitor and redox cycler drug methylene blue (MB).

76 catalytic reduction of H2O2 by oxidation of methylene blue (MB).

77 ry after extinction training by low-dose USP methylene blue (MB).

78 a primary role in driving the degradation of methylene blue (MB).

79 ; ii) electropolymerization of the mediator, methylene blue (MB); iii) immobilization of the enzyme l

80 the phenothiaziums Methylene Blue (MB), New Methylene Blue (NMB), 1,9-Dimethyl Methylene Blue (DMMB)

81 Combination of Methylene Blue + 1,9-Dimethyl Methylene Blue demonstrate

82 pain-gel with a red-light absorbing pigment (methylene blue - MB) to mediate photodynamic therapy (PD

83 determine the affinity constant, KD, of the methylene blue Affimer to be comparable to that of antib

84 We also observed that Methylene Blue, New Methylene Blue and 1,9-Dimethyl Methylene Blue increased

85 grade silicone incorporating crystal violet, methylene blue and 2 nm gold nanoparticles.

86 toring of the photocatalytic degradations of methylene blue and methyl orange under different flow ra

87 h to highlight the exceptional properties of methylene blue as a redox reporter in such applications

88 Apt and CS and so, increases accumulation of methylene blue as redox agent on the surface of electrod

89 ndicates that a PEG-based peptide, employing methylene blue as redox reporter, and deposited on an el

90 alytic activity in the reduction reaction of methylene blue by stannous chloride.

91 Conclusion Low-dose methylene blue can increase functional MR imaging activi

92 g release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity.

93 Combination of Methylene Blue + 1,9-Dimethyl Methylene Blue demonstrated superior efficacy compared t

94 Topically applied methylene blue dye chromoendoscopy is effective in impro

95 e feasibility of the foam as an adsorbent of methylene blue dye.

96 d classification system, ex vivo videos of a methylene blue dyed pig esophagus and images of differen

97 -dependent multimatrix structure, a per-oral methylene blue formulation (MB-MMX) can be delivered dir

98 terial displayed instantaneous adsorption of methylene blue from aqueous solution reaching complete e

99 ral correlates of the oral administration of methylene blue in the healthy human brain.

100 nzthiazoline-6-sulfonic acid), dopamine, and methylene blue in the presence of O2.

101 r catalytic activity toward the reduction of methylene blue in the presence of sodium borohydride.

102 sible for exo-HAV infectivity as assessed by methylene blue inactivation of non-encapsidated RNA.

103 ne Blue, New Methylene Blue and 1,9-Dimethyl Methylene Blue increased by 5000% the reactive oxygen sp

104 d concentration may be altering the modes of methylene blue interaction with the nucleic acids and ch

105 raction (DLLME) to extract the aqueous-phase methylene blue into organic media.

106 on alters the accessibility of Cr(VI) to the methylene blue label on the surface-immobilized DNA prob

107 e surface, resulting in less accumulation of methylene blue on the electrode surface and a weak curre

108 g the retention of the ion-pairs formed with Methylene Blue on the muMNPC.

109 and 1 hour after administration of low-dose methylene blue or a placebo.

110 The efficiency of the BNNTs for capturing methylene blue particles in water was approximately 94%,

111 f photocatalytic reactions in an Ag nanocube-methylene blue plasmonic system.

112 talization, here we profiled spontaneous and methylene blue plus light-induced mutations in the cII g

113 a low limit of detection (10(-9) M) for the methylene blue probe molecule.

114 ounds could be visualized after the jumps by methylene blue staining and scanning electron microscopy

115 Because primaquine and methylene blue sterilize gametocytes before affecting th

116 action procedure is employed to transfer the methylene blue to aqueous media, followed by analysis of

117 first adaptor strand contains a redox label methylene blue to trigger the current change in response

118 Methylene blue was also associated with a 7% increase in

119 ) and a synergistic effect was achieved when Methylene Blue was combined with New Methylene Blue (Com

120 Two milliliter of methylene blue were instilled above the cuff to quantify

121 generally due to more redox molecules (e.g., methylene blue) associating with the probe DNA bases in

122 Pyronin Y, Auramine O, Brilliant green, and Methylene blue) contaminants, and, in addition, this MTV

123 n Toray paper as support and a layer of poly(methylene blue)/tetrabutylammonium bromide/Nafion and gl

124 We also demonstrate that methylene blue, a reported tau aggregation inhibitor, mo

125 ng electrochemical biosensors, ferrocene and methylene blue, along with the effect of changing both t

126 guest adsorbate, containing both HgCl(2) and Methylene blue, and offered unprecedented snapshots of t

127 reduction reaction between ascorbic acid and methylene blue, followed by a dispersive liquid-liquid m

128 uced plasma sound source) to deliver agents (methylene blue, MB, in PBS) into bovine AC.

129 We also observed that Methylene Blue, New Methylene Blue and 1,9-Dimethyl Meth

130 n, we employ MLS to analyze contrast agents (methylene blue, rhodamine 800, Alexa Fluor 750, IRDye 80

131 We used three synthetic photosensitizers (methylene blue, rose bengal, and nitrite) and two model

132 A binding is measured by a redox active dye, methylene blue, that intercalates in dsDNA, leading to a

133 Teeth were stained with 1% methylene blue, the largest interproximal calculus depos

134 the cyclic "ON"/"OFF" binding of ATP to the methylene blue-functionalized aptamer through cyclic oxi

135 Importantly, we find that the oxidized methylene blue-modified aptamers bind to ATP with microm

136 itchable aptamer binding to ATP. A series of methylene blue-modified ATP-aptamers was synthesized, re

137 Photooxidation of methylene blue-NP41-bound nerves, followed by biotin hyd

138 Methylene blue-tagged peptides combined with a polyethyl

139 minal deoxynucleotidyl transferase (TdT) and methylene blue.

140 tion of small organic target compounds, here methylene blue.

141 nts up to 3.4 x 10(3) for the probe molecule methylene blue.

142 e Csp(3)-H arylation of the unactivated beta-methylene bond of beta-alanine.

143 of one N(SiMe(3))(2) ligand and the uranium-methylene bond.

144 traction in TAA by DPPH was located on -CH2- methylene bridge because the corresponding radical was m

145 Methylene bridge formation has profound effects on the p

146 The methylene bridge next to the fluorene moiety is intramol

147 al and computational), an active role of the methylene bridge was revealed, acting as a base towards

148 The novel title macrocycles, based on methylene-bridged 1,5-naphthalene units, have been obtai

149 presence of CO2 or formaldehyde form mutual, methylene-bridged cross-links between Lys(158) and Cys(2

150 in highly fluorescent compounds such as N,N-methylene-bridged dipyrrinones and xanthoglows.

151 s and supramolecular properties of the first methylene-bridged propanediurea-based dimers are describ

152 mR (EcFrmR) protein reveals the formation of methylene bridges that link adjacent Pro2 and Cys35 resi

153 Calix[6]arenes disubstituted at the methylene bridges, which are stable in the cone or 1,2,3

154 the addition of silver salt is desirable for methylene but not for methyl fluorination.

155 ficient 2-pyridone ligand to enable the beta-methylene C(sp(3) )-H arylation of aliphatic alcohols, w

156 Selective bromination of gamma-methylene C(sp(3) )-H bonds of aliphatic amides and delt

157 p(3) )-H bonds of aliphatic amides and delta-methylene C(sp(3) )-H bonds of nosyl-protected alkyl ami

158 The beta-methylene C(sp(3) )-H bonds of various carbocyclic rings

159 ctive alkoxycarbonylation of both methyl and methylene C(sp(3))-H bonds with alkyl chloroformates thr

160 ive palladium catalysts for the arylation of methylene C(sp(3))-H bonds, and herein, we investigate t

161 However, methylene C(sp(3))-H carbonylation remains a great chall

162 II)-catalyzed C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead t

163 e past decade, the ability to oxidize strong methylene C-H bonds in the presence of more oxidatively

164 f methods for functionalization of the alpha-methylene C-H bonds of these highly privileged building

165 opment of methods to functionalize the alpha-methylene C-H bonds of these systems enantioselectively

166 ligands for the enantioselective coupling of methylene C-H bonds with aryl boronic acids.

167 Selective methylene C-H oxidation for the synthesis of alcohols wi

168 sing reactions, where E-butene serves as the methylene capping agent, are provided.

169 In situ methylene capping is introduced as a practical and broad

170 The in situ methylene capping strategy was used with the same Ru cat

171 retentive processes, which includes adopting methylene capping strategy.

172 2'-Fluoro-6'-methylene-carbocyclic adenosine (FMCA, 12) and its phosp

173 sertion into prochiral C-H bonds on a single methylene carbon center.

174 to a tRNA(Glu)substrate through the terminal methylene carbon of a formerly methylcysteinyl residue a

175 iral carbon-hydrogen (C-H) bonds on a single methylene carbon via asymmetric metal insertion remains

176 Robenidine, 1 (2,2'-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide), was active against

177 IRMOF-1-type lattice, six, seven, and eight methylene (-CH(2)-) groups between 1,4-benzenedicarboxyl

178 > carbonyl (CO) approximately ester (COO) > methylene (CH2).

179 A similar diphosphine with longer methylene chains, P((CH2)18)3P, is equally effective.

180 A 75/25 acid capped (13 kDa Mw) dissolved in methylene chloride (DCM) was spray-dried before washing

181 s via the nucleophilic addition of an active methylene compound to the aryne followed by ring closing

182 Active methylene compounds react with in situ generated nonstab

183 for the two bonds departing from the central methylene considerably affects the binding of compound 1

184 oth intra- and intermolecular aldehyde alpha-methylene coupling with olefins to construct both cyclic

185 that N-[(5-amino-1,3-diaryl-1H-pyrazol-4-yl)methylene]cyanamide is the intermediate.

186 of dichloroketene on a readily prepared exo-methylene cyclopentane building block.

187 lpha-Methylene-gamma-butyrolactone and alpha-methylene-delta-valerolactone undergo Pd-catalyzed Matsu

188 MDA is a precursor to methylene diphenyl diisocyanate (MDI), a hard block comp

189 5 procedures performed on children: (99m)Tc-methylene diphosphate (MDP) bone scans, (99m)Tc-mercapto

190 the binding mode of adenosine 5'-(alpha,beta-methylene)diphosphate (AOPCP) with human CD73, we design

191 ific CD73 inhibitor (adenosine 5'-alpha,beta-methylene-diphosphate) enhanced the microbicidal M1 subs

192 nventional imaging (CT or MRI, and a (99m)Tc-methylene diphosphonate bone scan) before enrollment.

193 ncer patients after a single 600-MBq (99m)Tc-methylene diphosphonate injection.

194 drolyzable GTP analog, guanylyl-(alpha,beta)-methylene-diphosphonate (GMPCPP), to examine the structu

195 utic (200 g/ton) concentration of bacitracin methylene disalicylate (BMD) to commercial turkeys for 1

196 he ester moiety and hydrogenation of the exo-methylene double bond of the bicyclo[3.2.1]oct-2-ene add

197 C5 is the largest to date for a nonanomeric methylene due to an unprecedented through-space n --> si

198 phenylene) bipyridin-1-ium-1,4-phenylene-bis(methylene)) (ExBox(4+)) to form both the ExBox(3+*) and

199 -cyclohexanedione, whereas the cyclic aminal methylene exhibits greater stability.

200 of Ag results in a lower energetic span for methylene fluorination and a higher energetic span for m

201 ion state for the oxidative addition step in methylene fluorination, thus uncovering a potential new

202 ep is likely the oxidative addition step for methylene fluorination, while it is likely the C-H activ

203 te that the enzyme's reduced flavin relays a methylene from the folate carrier to the nucleotide acce

204 The 2-methylene-furan-3-one reductase or Fragaria x ananassa E

205 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurri

206 alpha-Methylene-gamma-butyrolactone and alpha-methylene-delta-

207 est that an isatin-derived spirocyclic alpha-methylene-gamma-butyrolactone is a suitable core for opt

208 e-gamma-lactone by replacement with an alpha-methylene-gamma-lactam.

209 Guaianolide analogues having alpha-methylene-gamma-lactams are synthesized using the alleni

210 lly tuning the electrophilicity of the alpha-methylene-gamma-lactone by replacement with an alpha-met

211 r the synthesis of an optically active alpha-methylene-gamma-lactone from p-chlorostyrene has been de

212 nylation reaction with formation of an alpha-methylene-gamma-lactone proved instrumental, which had n

213 d against parthenolide and a synthetic alpha-methylene-gamma-lactone showing a positive correlation b

214 alpha-Methylene-gamma-lactones are present in ~3% of known nat

215 allantoic acid, hydroxymethylglutamate, and methylene glutamate, compared to uninfected plants.

216 Using methylene green and thionine acetate as redox mediators

217 nal studies confirmed that the presence of a methylene group attached to C-22 restricts the conformat

218 Intramolecular exchange of the methylene group bound to the metal within the cyclopenta

219 d protocol using 2-bromoaldehydes and active methylene group containing substrates that affords multi

220 ent functionalization of the unreactive beta-methylene group in an unprecedented tandem fashion and u

221 Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a

222 nd orthogonal specificities even if only one methylene group is exchanged between the polymer backbon

223 Metal-free insertion of a methylene group was achieved for the construction of a n

224 of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocentres containing fluor

225 unctionalization of primary C-H bonds, while methylene groups are unreactive in the absence of extern

226 d NSPD are different only with the number of methylene groups between amine groups, [N-3-N-4-N] and [

227 66-type lattice, an optimal spacing of seven methylene groups between bdc(2-) units is needed to mini

228 e, piperidine) and alkylene spacers (2 to 10 methylene groups between carbamate and heterocycle) in t

229 m alkanes were prepared, where the number of methylene groups between the ammonium groups ranges from

230 Methyl as well as cyclic and acyclic methylene groups can be activated.

231 sive regioselectivity in the presence of two methylene groups in different steric environments.

232 fatty acids in intramyocellular lipids, and methylene groups in extramyocellular lipids were found.

233 capable of C-H functionalization in acyclic methylene groups in the absence of external ligands, thu

234 proteinaceous analogs of Lys harboring fewer methylene groups in their side chains.

235 The methylene groups of R provide an experimental probe of t

236 With seven methylene groups, polyUiO-66-7a shows 7 +/- 3% of uncoor

237 ker lengths over a range from three to seven methylene groups.

238 The functionalized activated methylene halides employed in these reactions for the sy

239 thiolate salts with functionalized activated methylene halides.

240 y, the introduction of a methyl group at the methylene hinge connecting the 6-amino-9H-purin-9-yl pen

241 A, the dimethyl analogue 2 and four isomeric methylene homologues (including the natural product itse

242 es F(-) through its partially positive gamma-methylene in mimicry of phenylalanine's quadrupolar inte

243 oadly applicable catalytic cross coupling of methylene ketones and secondary alcohols with a series o

244 onditions for Matsuda-Heck arylations of exo-methylene lactones were eventually applied to the synthe

245 tetrazine linker that is substituted with a methylene-linked carbamate, leading to a 1,4-elimination

246 Methylene-linked cycloaliphatic or beta-branched substit

247 ffinity and residence time compared to their methylene-linked structural analogues.

248 uthenium(II) complexes bridged by a flexible methylene linker have received considerable interest as

249 y (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl gro

250 ly modulated by hydroxyl substitution on the methylene linker, where the R-hydroxy isomer has a 60-fo

251 ]pyrrol-2-yl)benzo[c][1,2,5 ]thiadiazol-4-yl)methylene)malononitrile leads to an increased open-circu

252 ]pyrrol-2-yl)benzo[c][1,2,5 ]thiadiazol-4-yl)methylene)malononitrile.

253 er of one-carbon unit intermediates (formyl, methylene, methenyl, methyl).

254 and hydride transfers, and methyl as well as methylene migrations, followed by reaction quenching.

255 n of the steroidal side chain and inserted a methylene moiety in position C-22 together with either l

256 ster linkage between Glu6 and the nascent C4 methylene moiety of DMIA.

257 The benzylic methylene moiety was found to be the source of the aroyl

258 rmation of tricycles possessing an exocyclic methylene moiety, whereas base-mediated conditions led t

259 has been replaced by the cyano(4-nitrophenyl)methylene moiety.

260 diazepine ternary center and the side chain methylene moiety.

261 ed for the imidazolium C(2)-CH3 protons, the methylene N-CH2 protons, and the inner aromatic proton o

262 ionic macrocycle which contains two N,N'-bis(methylene)naphthalenediimide units inserted in between t

263 y by the oxathiolane of 3TC-TP and exocyclic methylene of ETV-TP.

264 e more in favor of the methyl group than the methylene of the pentyl chain, in excellent agreement wi

265 egrees of degradation of target contaminant, methylene orange, under ambient temperature and near-neu

266 Late-stage methylene oxidation is demonstrated on four drug scaffol

267 Preparative remote methylene oxidation is obtained in 50 aromatic compounds

268 f (153)Sm-ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acid) (EDTMP).

269 lic phosph(on)ate analogues (4-6), isosteric methylene phosphono analogues (7 and 8), and 6-fluoro-al

270 scaffold for synthetic elaboration at the 2-methylene position thereby affording extended oxazoles.

271 containing substituents that render the two methylene positions in each phthalan inequivalent.

272 orinated selectively at the gamma-methyl and methylene positions.

273 ed (1)H resonances originating from the four methylene protons of the azadithiolate ligand in the [2F

274 (2))-H and one C(sp(3))-H bond of the active methylene residue.

275 to release 1 in rats, the introduction of a methylene spacer facilitated prodrug activation, but par

276 ate of CH3ReO3/Al2O3 is a distribution of mu-methylene species formed by the activation of the C-H bo

277 ndom coil, water content, lipid carbonyl and methylene stretching across the sampled area.

278 xtensive series of DFT calculations, that mu-methylene structures (Al-CH2-ReO3-Al) containing a Re ho

279 ic alcohol derivatives possessing a terminal methylene substituent.

280 tom-'substituted' NTPs, we elucidate how the methylene substitution in the pyrophosphate leaving grou

281 bonds in U:dT recovers a strong response to methylene substitution of UTP.

282 E)-2-{[(1-tert-butoxycarbonyl)-1H-indol-3-yl]methylene}succinate and (R)-2,2,5,5-tetramethyl-1,3-diox

283 rial one-carbon metabolism by suppression of methylene tetrahydrofolate dehydrogenase/cyclohydrolase.

284 galy was rescued by genetic ablation of 5,10-methylene tetrahydrofolate reductase (Mthfr), which resu

285 We assessed a causal relationship of WMH to methylene tetrahydrofolate reductase (MTHFR).

286 atalyzes the irreversible conversion of 5,10-methylene-tetrahydrofolate (THF) to 5-methyl-THF, thereb

287 mmon polymorphisms, the c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an en

288 h the production of the one-carbon unit 5,10-methylene-tetrahydrofolate, is a direct transcriptional

289 n the substrate contains nonequivalent gamma-methylenes, the site-selectivity for lactonization can b

290 nversion of tetrahydrofolate (THF) into 5,10-methylene-THF (5,10-meTHF).

291 -(4-bromophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)thiazolidine-2,4- dione (2), a thiazolidine-2,

292 n, we chemically synthesized and evaluated a methylene thioacetal human insulin analogue (SCS-Ins).

293 intramolecular sulfamidation at the benzylic methylene to give N-arylsuflonyl-1-arylisoindolinones, w

294 The additional methylene unit in the [3.3]paracyclophane bridge results

295 The latter contain an extra methylene unit in the peptide backbone but retain the or

296 Herein, we report that the replacement of a methylene unit of the adamantane group by an oxygen atom

297 3, corresponding to the number of catenated methylene units between imino nitrogen atoms).

298 hese macrocycles consist of two TPAs and two methylene ureas, which drive the assembly into porous or

299 products depend on the nature of the active methylene used.

300 indicating the dominance of antisymmetric CH methylene vibrations as the anhydrous milk fats crystal