ライフサイエンスコーパス: methylmalonic acid

1 total transcobalamin, total haptocorrin, and methylmalonic acid.

2 ular mitochondrial inhibitor and neurotoxin, methylmalonic acid.

3 modeling associated the presence of HT with methylmalonic acid, 4-hydroxyphenylpyruvic acid, palmiti

4 th higher concentrations of homocysteine and methylmalonic acid and higher odds ratios for cognitive

5 w serum vitamin B12 levels or elevated serum methylmalonic acid and homocysteine levels.

6 the C-H and C-N modulated CSA experiments on methylmalonic acid and N-tBoc-glycine, respectively.

7 reased intracellular levels of propionic and methylmalonic acid and subsequent inhibition of HMGCR ac

8 e highest concentrations of homocysteine and methylmalonic acid and the lowest concentration of holot

9 eficiency who received treatment (15 of 21), methylmalonic acid and total homocysteine levels decreas

10 sorders characterized by the accumulation of methylmalonic acid and/or homocysteine in blood and urin

11 Elevated methylmalonic acid and/or total homocysteine are sensiti

12 lasma total vitamin B-12, 3 studies measured methylmalonic acid, and 6 studies measured total homocys

13 rum and red blood cell folate, vitamin B-12, methylmalonic acid, and homocysteine concentrations amon

14 ean pretreatment values for serum cobalamin, methylmalonic acid, and homocysteine were, respectively,

15 the amount of B12 bound to TCII (holoTCII), methylmalonic acid, and homocysteine, in 128 healthy old

16 were assessed for vitamin B12, folate, Hcy, methylmalonic acid, and next-generation clinical exome s

17 elevation of the metabolites, homocysteine, methylmalonic acid, and the ligand, transcobalamin II, i

18 serum concentrations of total vitamin B-12, methylmalonic acid, and total homocysteine are all effec

19 Serum levels of vitamin B12, folate, methylmalonic acid, and total homocysteine measured befo

20 Serum levels of vitamin B(12), folate, methylmalonic acid, and total homocysteine were assayed

21 n status (defined by low cobalamin, elevated methylmalonic acid, and/or elevated homocysteine concent

22 ency (homocysteine, hydroxykynurenine-ratio, methylmalonic acid) at recruitment, 1 month after commen

23 ry results were significantly raised urinary methylmalonic acid compared with age-matched controls (p

24 n B-12 concentration < 148 pmol/L or a serum methylmalonic acid concentration > 210 nmol/L-the maximu

25 n B-12 concentration <148 pmol/L or a plasma methylmalonic acid concentration > or =210 nmol/L, the p

26 re, each 2-fold increment in homocysteine or methylmalonic acid concentration was associated with a d

27 with vitamin B-12 was associated with lower methylmalonic acid concentrations (P < 0.001).

28 Mean serum vitamin B-12 and methylmalonic acid concentrations did not differ; howeve

29 In addition, mean methylmalonic acid concentrations were significantly low

30 ed blood cell folate, serum homocysteine, or methylmalonic acid concentrations.

31 and beta-carotene and lower homocysteine and methylmalonic acid concentrations.

32 vitamin B-12 deficiency with elevated serum methylmalonic acid concentrations.

33 one users also had significantly lower serum methylmalonic acid concentrations.

34 ither vitamin B-12 or folate deficiency, and methylmalonic acid for detection of vitamin B-12 deficie

35 74.1 nmol/L, and low vitamin B-12 status as methylmalonic acid > 271 nmol/L or serum vitamin B-12 <

36 B-12 function (vitamin B-12 <200 pmol/L and methylmalonic acid >0.27 micromol/L) in the total group

37 in B-12 concentrations <150 pmol/L, or serum methylmalonic acid >376 nmol/L.

38 ine, S-adenosylmethionine, vitamin B(12), or methylmalonic acid), hematological measures, nor clinica

39 Homocysteine, methylmalonic acid, holotranscobalamin, ratio of holotra

40 One year after transplant, urine methylmalonic acid indicates good vitamin B12 absorption

41 using markers such as holotranscobalamin and methylmalonic acid, it has been found that cognition is

42 depression, had a significantly higher serum methylmalonic acid level and a nonsignificantly lower se

43 2 level less than 221 pmol/L and an elevated methylmalonic acid level; 2) a serum vitamin B12 level l

44 The higher serum cobalamin and lower serum methylmalonic acid levels at 4 months posttreatment in t

45 canisters consumed per week correlated with methylmalonic acid levels in the blood as a measure of f

46 alization of elevated total homocysteine and methylmalonic acid levels may prevent the development of

47 Methylmalonic acid may contribute to neuronal injury in

48 tus [ie, plasma vitamin B-12 < 148 pmol/L or methylmalonic acid (MMA) > 210 nmol/L] with respect to a

49 racteristics of metabolic biomarkers such as methylmalonic acid (MMA) and holotranscobalamin II, whos

50 oloTc), or B(12)-associated metabolites like methylmalonic acid (MMA) and homocysteine (Hcy) concentr

51 exists at which the relation between plasma methylmalonic acid (MMA) and SB-12 changes slope to diff

52 al, cognitive, routine diagnostic, and serum methylmalonic acid (MMA) and total homocysteine (tHcy) t

53 Elevated plasma methylmalonic acid (MMA) and/or total homocysteine (tHcy

54 olate, serum vitamin B-12, homocysteine, and methylmalonic acid (MMA) concentrations in US children b

55 Plasma cobalamin and methylmalonic acid (MMA) concentrations were analyzed am

56 folate, vitamin B12, homocysteine (Hcy), and methylmalonic acid (MMA) concentrations with epigenetic

57 m Offspring Study, and performed analyses of methylmalonic acid (MMA) continuously and <210 nmol/L; p

58 Persons with high folate and normal methylmalonic acid (MMA) had lower odds of PCP (OR: 0.56

59 cobalamin (HoloTC), homocysteine (tHcy), and methylmalonic acid (MMA) have been measured.

60 12, and plasma total homocysteine (tHcy) and methylmalonic acid (MMA) in the US population.

61 Methylmalonic acid (MMA) is a by-product of propionic ac

62 Serum methylmalonic acid (MMA) is a specific functional indica

63 sis on the association between rs1801198 and methylmalonic acid (MMA) lacked statistical power.

64 Urinary methylmalonic acid (MMA) may be a more informative bioma

65 Plasma folate, vitamin B-12, and methylmalonic acid (MMA) were assessed in fasting blood

66 anscobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA) were measured before and after

67 Specifically, we show that methylmalonic acid (MMA), a by-product of propionate met

68 Systemic levels of methylmalonic acid (MMA), a byproduct of propionate meta

69 , we bring to light the multifaceted role of methylmalonic acid (MMA), a byproduct of the propionate

70 B(12) status, total homocysteine (tHcy) and methylmalonic acid (MMA), among adult participants in ph

71 Here, we show that methylmalonic acid (MMA), an aging-increased oncometabol

72 min B-12, holotranscobalamin (holoTC), tHcy, methylmalonic acid (MMA), and folate with the use of lin

73 amin B-12, plasma total homocysteine (tHcy), methylmalonic acid (MMA), and holotranscobalamin into on

74 However, diagnostic algorithms using Cbl, methylmalonic acid (MMA), and homocysteine (HCys) measur

75 tus used in past NHANES--serum vitamin B-12, methylmalonic acid (MMA), and total homocysteine (tHcy)-

76 cy), cobalamin, holotranscobalamin (holoTC), methylmalonic acid (MMA), red blood cell folate (RBCF),

77 parison of baseline serum cobalamin, folate, methylmalonic acid (MMA), total homocysteine (tHcy), and

78 Methylmalonic acid (MMA), total homocysteine, and other

79 n and elevated total homocysteine (tHcy) and methylmalonic acid (MMA).

80 ma cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA).

81 plasma total homocysteine (tHcy), and plasma methylmalonic acid (MMA)].

82 the use of vitamin B-12 than with the use of methylmalonic acid (MMA; 3-26% and 2-6%, respectively).

83 vels of cobalamin (normal, 200 to 900 pg/mL) methylmalonic acid (normal, 73 to 271 nmol/L), and homoc

84 ne, kynurenine, leucine, lysine, methionine, methylmalonic acid, ornithine, phenylalanine, proline, s

85 in the brain was evident from the increased methylmalonic acid (P<0.01-0.04), homocysteine (P<0.01),

86 or (S-TfR), plasma cobalamin (P-Cob), plasma methylmalonic acid (P-MMA), plasma folate (P-Fol), and s

87 vitamin B12, plasma homocysteine, and plasma methylmalonic acid (pMMA) concentration and urinary meth

88 , show failure to thrive, and show increased methylmalonic acid, propionylcarnitine, odd chain fatty

89 ene of Pseudomonas aeruginosa, which encodes methylmalonic acid semialdehyde dehydrogenase (MSDH) and

90 rum vitamin B-12, total homocysteine (tHcy), methylmalonic acid, serum folic acid, and 5-methyltetrah

91 ion test and measurement of homocysteine and methylmalonic acid, to cobalamin status has identified t

92 alonic acid (pMMA) concentration and urinary methylmalonic acid-to-creatinine ratio.

93 mentation may be effective in lowering serum methylmalonic acid values in the elderly.

94 s of vitamin B-12, folate, homocysteine, and methylmalonic acid were measured.

95 Methylmalonic acid, which is formed from the MCM substra

96 as associated with elevated homocysteine and methylmalonic acid, which were reduced by folate and vit

97 f folate, cobalamin, total homocysteine, and methylmalonic acid with cognitive performance at 2 occas

98 elderly population as documented by elevated methylmalonic acid with or without elevated total homocy

99 The use of serum vitamin B-12 and plasma methylmalonic acid would provide continuity with past NH