ライフサイエンスコーパス: methylthio

1 In the second method, the corresponding 3-(methylthio)-1,3-bis(het)aryl-2-propenones (prepared in s

2 ne ketones, by reacting in situ generated 3-(methylthio)-1,3-bis(het)aryl-2-propenones with arylhydra

3 2-(Methylthio)-1,3-dithioles are important heterocyclic com

4 ly accessible 1,3-dithiole-2-thiones into 2-(methylthio)-1,3-dithioles by methylation with trimethyl

5 lectrophilic cyclization reaction between 2-(methylthio)-1-(3-arylprop-2-yn-1-yl)-1H-benzo[d]imidazol

6 butanoic acid, and 3-methylbutanoic acid; 3-(methylthio)-1-propanol; hexanoic acid; beta-damascenone;

7 rical 1,2,4,5-tetrazines, 3-methylsulfinyl-6-methylthio-1,2,4,5-tetrazine (4) and 3-(benzyloxycarbony

8 based on two side-chains of the A subunit, 3-methylthio-1,4-diphenyl-1H-1, 3,4-triazolium (MDT) was i

9 The versatility of the 4-methylthio-1-butyl phosphate/thiophosphate protecting gr

10 The thermolabile 4-methylthio-1-butyl phosphate/thiophosphate protecting gr

11 namely 2-methylthio-2-phenyl-1-ethanol and 2-methylthio-1-phenyl-1-ethanol.

12 acetate, ethyl octanoate, ethyl decanoate, 3-methylthio-1-propanol, carvone, benzyl alcohol and nonan

13 methyl sulfide, 1-methylthio-propane, (Z)-1-methylthio-1-propene, and (E)-1-methylthio-1-propene, ha

14 opane, (Z)-1-methylthio-1-propene, and (E)-1-methylthio-1-propene, had not previously been associated

15 mide gave good yields of the corresponding 2-methylthio (12) and the 2-benzylthio (13) analogs.

16 2-azido (10), 2-amino (11), 2-thione (13), 2-methylthio (14a), and 2-benzylthio (14b) derivatives wer

17 ido-N-(4-((4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1H-imidazol-5-y l)pyridin-2-yl)amino)phenyl)

18 K3), 2-bromo-3-substituted-1H-1-indenones, 2-methylthio-1H-1-indenones, 3-butyne-1,2-dione, and 4-pen

19 y synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and

20 cathinone, 4-methyl pentedrone, 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MMMP), 1-(3-chlor

21 The synthetic precursors alkyl 2-(methylthio)-2-thioxoacetates/alkyl 2-amino-2-thioxoaceta

22 The (N)-methanocarba-2-methylthio, 2-methylseleno, 2-hexyl, 2-(1-hexenyl), and

23 an accurate measurement of the level of S(6)-methylthio-2'-deoxyguanosine (S(6)mdG) in DNA of cells t

24 guanine (6-TG) in DNA can be converted to S6-methylthio-2-aminopurine (2-AP-6-SCH3) and 2-aminopurine

25 on involving organomagnesium reagents and (3-methylthio-2-azaallyl)stannanes with a Ni(0) catalyst pr

26 used, resulting in the formation of 5,6-bis-methylthio-2-chloro-3-(beta-D-ribofuranosyl)pyrazine and

27 nd human tumor cell lines, indicating that 4-methylthio-2-oxobutanoic acid acts as a negative regulat

28 The MAMS-catalyzed condensation of 4-methylthio-2-oxobutanoic acid and acetyl-CoA generates a

29 ray crystal structure, involves binding of 4-methylthio-2-oxobutanoic acid followed by acetyl-CoA.

30 f the penultimate salvage pathway compound 4-methylthio-2-oxobutanoic acid represses ODC levels in bo

31 P1 siRNA and the pharmacological inhibitor 4-methylthio-2-oxobutyric acid (MTOB) were used to abrogat

32 ce with the CtBP small-molecule inhibitors 4-methylthio-2-oxobutyric acid and 2-hydroxy-imino phenylp

33 duced two methylthiophenylethanols, namely 2-methylthio-2-phenyl-1-ethanol and 2-methylthio-1-phenyl-

34 by reacting the corresponding 1-(het)aryl-1-(methylthio)-4-(het)arylidene-but-1-en-3-ones with sodium

35 protocol was developed, utilizing 2-amino-6-(methylthio)-4-(trimethylsilyl)nicotinonitrile as the key

36 t route to 2-phenyl/(2-thienyl)-5-(het)aryl/(methylthio)-4-functionalized thiazoles via one-step chem

37 beta-bis(methylthio)enamides to 2-phenyl-5-(methylthio)-4-substituted oxazoles.

38 paration of fluorescent and non-fluoresent 3-methylthio-4-arylmaleimides in a single step through a n

39 lites such as uremic toxins (2,3-dihydroxy-5-methylthio-4-pentenoic acid [DMTPA], N2N2dimethylguanosi

40 loped for the synthesis of functionalized 2-(methylthio)-4H-chromen-4-ones by intramolecular cyclizat

41 3-Halo-2-(methylthio)-4H-chromen-4-ones were achieved via various

42 Several cyclic 2-(methylthio)-5-amidofurans containing tethered unsaturati

43 A series of 2-(methylthio)-5-amidofurans containing tethered unsaturati

44 s desulfurization of the tetrabenzyl-6,6-bis(methylthio)-5-epi-valiolone and introduction of the deut

45 presence of sodium acetate to afford 5,6-bis(methylthio)-5-hexenol in 60% yield.

46 ceptors, whereas the P2Y1-specific agonist 2-methylthio-5'-adenosine diphosphate was, again, only eff

47 s II aldolase-like protein (Ald2) to form 2-(methylthio)acetaldehyde as an intermediate.

48 roxyacetone phosphate and acetaldehyde or (2-methylthio)acetaldehyde during both aerobic and anaerobi

49 2-(Methylthio)acetaldehyde is reduced to 2-(methylthio)etha

50 se radiolysis of aqueous solutions of alpha-(methylthio)acetamide produced unexpectedly large quantit

51 ether derived from commercially available 2-(methylthio)acetic acid are most effective.

52 of neuronal NOS (nNOS) by (S)-2-amino-5-(2-(methylthio)acetimidamido)pentanoic acid (1): sulfide oxi

53 vailable 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines

54 0.6%), p-cresol (16.3%), adenine (12.5%), 2-(methylthio)adenine (15.5%), 5-hydroxybenzimidazole (1.8%

55 s-2-methyladenine, p-cresol, adenine, and 2-(methylthio)adenine.

56 pholipase C stimulation elicited by 10 nM 2-(methylthio)adenosine 5'-diphosphate (antagonist effect).

57 enzyme results in formation of 5'-deoxy-5'-(methylthio)adenosine and not 5'-deoxyadenosine.

58 the methyltransferase inhibitor 5'-deoxy(5'-methylthio)adenosine markedly enhanced SP-A expression i

59 MTA [5'-deoxy-5'(methylthio)adenosine], a pharmacological inhibitor of pr

60 abotropic receptor agonist), serotonin, or 2-methylthio-adenosine triphosphate (2mATP, a purinergic r

61 MTI arises through the deamination of methylthio-adenosine, a product of the polyamine biosynt

62 an P2Y12R in complex with the full agonist 2-methylthio-adenosine-5'-diphosphate (2MeSADP, a close an

63 affinity, and that of the agonists ADP and 2-methylthio-adenosine-5'-diphosphate, was reduced.

64 Superfusion of 2-methylthio-adenosine-5'-triphosphate (2-M-S-ATP) over qu

65 tion, and the corresponding ATP derivative 2-methylthio-adenosine-5'-triphosphate (2MeSATP) at 3.1 A

66 d then adenosine 5'-triphosphate (ATP) by 5'-methylthio-adenosine/AdoHcy nucleosidase (MTAN), adenine

67 P2Y(1) receptor stimulation with 2-methylthio ADP (2-MeSADP) induced activation of GIRK cur

68 The potency at P2Y(12) was 2-(methylthio)-ADP > 2-(methylthio)-ATP > ADP > ATP.

69 ors (adenosine 5'-(2-O-thio) diphosphate = 2-methylthio-ADP >/= 2-methylthio-ATP >> ADP > ATP) differ

70 t aggregation and secretion in response to 2-methylthio-ADP (2-MeSADP) and AYPGKF were diminished in

71 concentration (EC(50)) values for ADP and 2-methylthio-ADP (2-MeSADP) when compared with the wild-ty

72 rconversion, and an order of affinities of 2-methylthio-ADP (2MeSADP) > ADP = 2-methylthioATP = adeno

73 amma2 was stimulated by addition of either 2-methylthio-ADP (2MeSADP) or RGS4 and was markedly enhanc

74 2-methylthio-ADP also showed no substrate inhibition, indi

75 An (N)-methanocarba-2-methylthio-ADP analogue displayed an EC(50) at the hP2Y(

76 Because changes in the potency of 2-methylthio-ADP and 2-(hexylthio)-AMP paralleled the chan

77 Both ADP and 2-methylthio-ADP caused a 3-fold increase in the level of

78 The P2Y1-selective agonist 2-methylthio-ADP increased [Ca(2+)]i in SGCs, and response

79 The P2Y(1) agonist 2-methylthio-ADP increased DBS, whereas the P2Y(1) antagon

80 1 was stimulated by ATP and UTP but not by 2-methylthio-ADP or adenosine.

81 In contrast, 2-methylthio-ADP promoted a substantial Ca(2+)(i) response

82 l. recently reported that, whereas ADP and 2-methylthio-ADP were agonists, ATP and 2-methylthio-ATP w

83 s incubated first with either ADP, ATP, or 2-methylthio-ADP were not labeled by 2-BrCH2(CO)2CH2S-ADP

84 P, but not 2',3'-O-(4-benzoyl)benzoyl-ATP, 2-methylthio-ADP, adenosine, or 5'-N-ethyl-carboxamidoaden

85 uid chromatographically purified ADP, ATP, 2-methylthio-ADP, and 2-methylthio-ATP resulted in rapid C

86 2Y(12) mutant retained normal responses to 2-methylthio-ADP, with an EC(50) of 0.15 +/- 0.04 nM.

87 However, 2-methylthio-ADP-induced intracellular Ca(2+) mobilization

88 was determined by measuring antagonism of 2-methylthio-ADP-stimulated phospholipase C (PLC) activity

89 active site that were not seen with UDP or 2-methylthio-ADP.

90 al stabilization of the P2RY12 receptor by 2-methylthio-ADP.

91 re we present the molecular structure of the methylthio-alkane reductase, which reveals large metallo

92 Methylthio-alkane reductases convert methylated sulfur c

93 kinetic study of the reaction of methyl beta-methylthio-alpha-nitrocinnamate (4-SMe) with morpholine,

94 nylation using palladium, copper, and the 2-(methylthio)amide directing group.

95 w classes of porphyrins, P1 and P2, with two methylthio anchoring groups in the 2,13- and 2,12-positi

96 Alkylation of this adduct gave the 2-methylthio and 2-benzylthio derivatives.

97 2-Methylthio and 2-chloro analogues were partial agonists

98 The (N)-methanocarba-2-methylthio and 2-chloromonophosphate analogues were full

99 The incorporation of (methylthio)aniline residues into a cage allowed for the

100 ntate ligands (e.g., 8-aminoquinoline and 2-(methylthio)aniline), has been investigated.

101 he auxiliaries such as, 8-aminoquinoline, 2-(methylthio)aniline, and N',N'-dimethylethane-1,2-diamine

102 activated alkyne for the synthesis of 2-[( o-methylthio)aryloxy]-substituted dialkyl maleates is repo

103 rank order of agonist potency was ATP >/= 2 methylthio ATP > adenosine 5'-O-(3-thiotriphosphate) > a

104 ATP-gamma-S and 2-methylthio ATP (2-Me-S-ATP) were significantly less effe

105 Only ATP and 2 methylthio ATP were full agonists.

106 2-Methylthio ATP, alpha,beta-methylene ATP and ADP activat

107 tency at P2Y(12) was 2-(methylthio)-ADP > 2-(methylthio)-ATP > ADP > ATP.

108 O-thio) diphosphate = 2-methylthio-ADP >/= 2-methylthio-ATP >> ADP > ATP) differs from that of hP2Y(1

109 The P2Y purinoreceptor partial agonist, 2-methylthio-ATP (2-MeS-ATP), inhibits the expression of i

110 ceptor agonists in these neurons was ATP > 2-methylthio-ATP (2-MeSATP) > > alpha, beta-methylene ATP

111 s UTP and UDP, also inhibited IAC, whereas 2-methylthio-ATP (2-MeSATP) and CTP were completely ineffe

112 The potent P2Y1 receptor agonist 2-methylthio-ATP (2-MeSATP) had no activity in cells expre

113 e full P2Y receptor agonists ATP, ADP, and 2-methylthio-ATP (2MeSATP).

114 We found that ATP, 2-methylthio-ATP (MT-ATP) and UTP increase cAMP production

115 the analogues alpha,beta-methylene-ATP and 2-methylthio-ATP also inhibited K(+) currents.

116 00 microM) and UTP (1-100 microM), but not 2-methylthio-ATP or adenosine, stimulated mobilization of

117 ATP or 2-methylthio-ATP produced post-stimulus rebound responses

118 y purified ADP, ATP, 2-methylthio-ADP, and 2-methylthio-ATP resulted in rapid Ca2+ responses, with EC

119 he effects of alpha,beta-methylene-ATP and 2-methylthio-ATP were determined by measuring transmembran

120 nd 2-methylthio-ADP were agonists, ATP and 2-methylthio-ATP were weak antagonists in studies of the h

121 '-(beta, gamma-methylene)triphosphate, and 2-methylthio-ATP) stimulated Ca2+ influx and contraction t

122 hable, with the P2X receptor agonists ATP, 2-methylthio-ATP, 2' and 3'-O-(4-benzoylbenzoyl)-ATP, and

123 2-Methylthio-ATP, alpha,beta-methylene-ATP, and adenosine

124 ate), adenosine-5'-O-(1-thiotriphosphate), 2-methylthio-ATP, and 3'-O-(4-benzoyl)benzoyl-ATP were rou

125 Similar full agonist activities of ATP, 2-methylthio-ATP, and ADP were observed in human embryonic

126 sponse to the nucleotide receptor agonists 2-methylthio-ATP, ATP, ADP, and UTP, but not the kinin rec

127 oligonucleotide treatment also blocked the 2-methylthio-ATP-stimulated increase in contractile amplit

128 d is further decreased by cotreatment with 2-methylthio-ATP.

129 ited the rebound response caused by ATP or 2-methylthio-ATP.

130 y from stoichiometric reactions employing 2-(methylthio)benzaldehdye.

131 Starting from the synthesis of bromo-2-(methylthio)benzaldehydes, a series of functionalization,

132 cular wire compared with its non-hemilabile (methylthio)benzene counterpart and demonstrate a previou

133 We compare the conductance of 1,4-bis(methylthio)benzene with that of 2,3,6,7-tetrahydrobenzo[

134 methoxybenzene, 4-(dimethylamino)benzene, 4-(methylthio)benzene), di- and trivinylarenes, and methyle

135 re benzothiazole, 2-hydroxy-benzothiazole, 2-methylthio-benzothiazole, 2-amino-benzothiazole, and 2-t

136 een glycine and the novel ligand (S)-2-(N-(2-methylthio)benzylprolyl)aminobenzophenone in the presenc

137 Thus, 8-(methylthio)-BODIPY (1) undergoes an S(N)Ar-type reaction

138 [blocked by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio) butadiene (U0126)], and therefore cAMP-depen

139 inhibitors, 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) and 2'-amino-3'-methoxyflav

140 nhibition by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) of an HGF downstream kinase

141 (PD98059) or 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126), two ERK kinase MAP inhibit

142 ttenuated by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126), which blocks the phosphory

143 K inhibitor [1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)], whereas PAR2 effects were

144 DL-2-hydroxy-(4-methylthio)butanoic acid (HMTBA) is a source of dietary

145 -enzymatic degradation yielding nitriles, 4-(methylthio)butyl GLS (4MTB-GLS) was shown to undergo sid

146 demonstrate the neuroprotective effect of 4-(methylthio)butyl isothiocyanate (4-MTBITC) against the 3

147 After analysis, 4-(methylthio)butyl isothiocyanate was observed to be the m

148 ory notes, along with 4-mercaptobutyl and 4-(methylthio)butyl isothiocyanate, associated with typical

149 neous quantification of allyl, 3-butenyl, 4-(methylthio)butyl, benzyl and phenethyl isothiocyanates.

150 kohlrabi broths for 120 min, recovery of 4-(methylthio)butyl-GLS as nitrile was 55.5 % in 1 g/mL bro

151 n and replacement of the N6-amino group with methylthio, chloro, or hydroxy groups greatly reduced th

152 dine C (ent-6) and gliocladin A (11), the di(methylthio) congener of bionectin A, are reported.

153 Here, we report 2-methylthio cyclic t6A (ms2ct6A), a novel derivative of c

154 pound was determined to be 3,5- dimethoxy-2-(methylthio)cyclohexa-2,5-diene-1,4-dione, and the blue c

155 ound was determined to be 5-methoxy-2,3- bis(methylthio)cyclohexa-2,5-diene-1,4-dione.

156 in the methionine salvage pathway in which 5-methylthio-d-ribose (MTR) derived from 5'-methylthioaden

157 Instead, MTA is converted to 5-methylthio-d-ribose 1-phosphate (MTR 1-P) and adenine; M

158 Methylthio-d-ribose-1-phosphate (MTR1P) isomerase (MtnA)

159 lvage" pathway in Bacillus sp. and (2) the 5-methylthio-d-ribulose 1-phosphate (MTRu 1-P) 1,3-isomera

160 2-proton transfer reactions) that converts 5-methylthio-D-ribulose 1-phosphate to a 3:1 mixture of 1-

161 MoAb1, recognizing the 5-methylthio-D-xylofuranose(MTX)-mannose(Man) cap epitope,

162 1-P) and adenine; MTR 1-P is isomerized to 1-methylthio-d-xylulose 5-phosphate (MTXu 5-P) and reducti

163 Methylthio-DADMe-immucillin-A (MT-DADMe-ImmA) is an 86-p

164 Methylthio-DADMe-immucillin-A (MTDIA) is a picomolar tra

165 Methylthio-DADMe-Immucillin-A (MTDIA) is an orally avail

166 (MTA) was blocked by inhibition of MTAP with methylthio-DADMe-Immucillin-A (MTDIA), an orally availab

167 Methylthio-DADMe-immucillin-A is a pyrrolidine analogue

168 nd evaluation of the two diastereomers of 10-methylthio-DDACTHF (10R-3 and 10S-3) and related analogu

169 The methylamino, thio, and methylthio derivatives were neither active nor cytotoxic

170 ation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines from diketopiperazines has

171 ization of highly functionalized novel beta-(methylthio)enamides as the key step has been reported.

172 er carbonate-induced cyclization of beta-bis(methylthio)enamides to 2-phenyl-5-(methylthio)-4-substit

173 ty to carry out conversion of methanol to 2-(methylthio)ethanesulfonate (methyl-CoM).

174 In addition, the thioether 2-(methylthio)ethanol (MTE) coordinates 0.5 kcal/mol more s

175 dicate anaerobic ethylene production from 2-(methylthio)ethanol requires protein synthesis and that t

176 Ethylene induction experiments using 2-(methylthio)ethanol versus sulfate as sulfur sources furt

177 2-(Methylthio)acetaldehyde is reduced to 2-(methylthio)ethanol, which is further metabolized as a us

178 mine (i-Hdiqa, [4](PF(6))(2)), and Hmte = 2-(methylthio)ethanol.

179 ur compounds such as dimethyl sulfide and (2-methylthio)ethanol.

180 ly((2-(methylsulfinyl)ethyl acrylate)-co-(2-(methylthio)ethyl acrylate)) (PAA-b-P(MSEA-co-MTEA)) with

181 ide monomer with methyl-thioether moiety, 2-(methylthio)ethyl glycidyl ether (MTEGE), which enables t

182 A novel 2'-modification, 2'-O-[2-(methylthio)ethyl] or 2'-O-MTE, has been incorporated int

183 inverse agonist and 5'-adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, mono

184 well-examined silver ionophore O,O' '-bis[2-(methylthio)ethyl]-tert-butylcalix[4]arene was monitored,

185 well-examined silver ionophore O,O' '-bis[2-(methylthio)ethyl]-tert-butylcalix[4]arene, the potassium

186 nts enhanced catalytic efficiency with 3-(2'-methylthio)ethylmalate approximately 100-fold and reduce

187 tIPMDH1-F137L) reduced activity toward 3-(2'-methylthio)ethylmalate by 200-fold, but enhanced catalyt

188 propylmalate dehydrogenase (IPMDH) and 3-(2'-methylthio)ethylmalate dehydrogenase catalyze the oxidat

189 ovel strategy for the synthesis of 2-aryl-3-(methylthio)furo[2,3-b]quinoxalines and involves 3-(1,2-d

190 tent oxidant to catalyze the attachment of a methylthio group (-SCH3) to C3 of aspartate 89 of protei

191 MiaB attaches a methylthio group at C2 of N(6)-(isopentenyl)adenosine, f

192 ulfide to afford 8-azachromones containing a methylthio group at C2.

193 RimO attaches a methylthio group at C3 of aspartate 89 of protein S12, a

194 MTAN with MT-ImmA indicates a dimer with the methylthio group in a flexible hydrophobic pocket.

195 d from d-ribose (5-OH group instead of the 5-methylthio group in MTR) as well as of the natural DK-MT

196 The presence of the methylthio group in these oligosaccharides was establish

197 PNP.MT-ImmH.SO(4) shows that the hydrophobic methylthio group inserts into a hydrophobic region adjac

198 with bound MT-Imm-A also reveals that the 5'-methylthio group lies in a flexible hydrophobic pocket.

199 The replacement of the methylthio group of substituted methylthiobenzylidene Me

200 e enzyme responsible for the attachment of a methylthio group on the beta-carbon of Asp88 of the smal

201 that RimO(rcn) catalyzes the attachment of a methylthio group to a peptide substrate analogue that mi

202 articular lead compound (lactam 1) with an N-methylthio group was able to induce DNA damage and inhib

203 Analogs of lactam 1 in which the N-methylthio group was replaced with other organothio chai

204 Substitution of the 5'-methylthio group with a 5'-phenylthio group gives an equ

205 Substitution of the methylthio group with a p-Cl-phenylthio group gives a mo

206 stant of 172 pM, slightly weaker than the 5'-methylthio group.

207 poptosis, demonstrating requirement of the N-methylthio group.

208 tRNA(Lys), despite the presence of the bulky methylthio group.

209 pod, with each arm of the tripod ending in a methylthio group.

210 of an autocatalytic system: oxidation of the methylthio groups into sulfoxides make them electron-def

211 tal-peptide cages that incorporate thiol and methylthio groups.

212 of 2-phenyl/(2-thienyl)-4-[bis(methylthio)/(methylthio)(het)arylmethylene]-5-oxazolo nes with alkoxi

213 philic ring-opening of newly synthesized 4-[(methylthio)hetero(aryl)methylene]-2-phenyl-5-oxazolone p

214 5'-Methylthio-Immucillin-A (MT-ImmA) is a slow-onset tight-

215 5'-Methylthio-Immucillin-A (MT-ImmA) is a transition state

216 Methylthio-immucillin-A (MT-ImmA) is an iminoribitol tig

217 5'-Methylthio-Immucillin-H (MT-ImmH) was designed to resemb

218 Moreover, TgPNP is insensitive to methylthio-immucillin-H (MT-ImmH), which inhibits PfPNP

219 5'-Methylthio-immucillin-H, a transition state analogue inh

220 ium enzyme, however, TgPNP cannot utilize 5'-methylthio-inosine (MTI).

221 The volatile profile consists mainly of bis(methylthio)methane (78.72%) and other minor constituents

222 When added to urine, synthetic (methylthio)methanethiol significantly enhances urine att

223 male urine; these neurons were activated by (methylthio)methanethiol, a potent, previously unknown se

224 stic insights show that the intermediate 3-((methylthio)methyl)-2-phenylimidazo[1,2-a]pyridine is gen

225 The anion formed from the lithiation of 1-[(methylthio)methyl]-1H-benzotriazole 1 with n-BuLi adds t

226 Y 097, (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthio-methyl)-3,4-dihydroquinox alin-2(1H)-thione)

227 t] The rates of hydrolysis of alpha-R-alpha-(methylthio)methylene Meldrum's acids (8-R with R = H, Me

228 hyl, vinyl, phenyl, formyl, acetyl, methoxy, methylthio, methylsulfinyl, methylsulfonyl, sulfamoyl, a

229 Substitution of 4-methylthio, methylsulfinyl, or ethyl to a benzyl group a

230 ring-opening of 2-phenyl/(2-thienyl)-4-[bis(methylthio)/(methylthio)(het)arylmethylene]-5-oxazolo ne

231 ubstrate; the four other naturally occurring methylthio modifications have been observed on tRNA.

232 P) is involved in the salvage of adenine and methylthio moieties of 5'-deoxy-5'-methylthioadenosine,

233 We used sulfur-modified methylthio molecules to passivate surface defects and su

234 2-(Methylthio)-N-(4-(naphthalen-2-yl)thiazol-2-yl)nicotinam

235 ifies N(6)-isopentenyladenosine (i(6)A) to 2-methylthio-N(6)-isopentenyladenosine (ms(2)i(6)A) in tRN

236 The 2-methylthio-N(6)-isopentenyladenosine (ms(2)i(6)A) modifi

237 LIAS, lipoic acid biosynthesis; CDK5RAP1, 2-methylthio-N(6)-isopentenyladenosine biosynthesis; CDKAL

238 nylmethyl-2-thiouridine (mcm(5)s(2)U(34)), 2-methylthio-N(6)-threonylcarbamoyladenosine (ms(2)t(6)A(3

239 N(6)-threonylcarbamoyladenosine (t(6)A) to 2-methylthio-N(6)-threonylcarbamoyladenosine (ms(2)t(6)A)

240 idine at position-34 (mcm(5)s(2)U(34)) and 2-methylthio-N(6)-threonylcarbamoyladenosine at position-3

241 )-isopentenyladenosine biosynthesis; CDKAL1, methylthio-N(6)-threonylcarbamoyladenosine biosynthesis;

242 y TUCB, including N(6)-methyladenosine and 2-methylthio-N(6)-threonylcarbamoyladenosine.

243 es are present in the anticodon stem-loop--2-methylthio-N6-threonylcarbamoyladenosine at position 37

244 4-fluoro-3-(trifluoromethyl)phenyl)amino)-3-(methylthio)naphthalene-1,3-dione (1), demonstrated signi

245 (4-cyanophenyl)amino)phenyl)thiazol-2-yl)-2-(methylthio)nicotinamide 26, which showed a VTR of 8.7 lo

246 Salvadenosine, (1) a rare 5'-deoxy-5'-(methylthio) nucleoside, was isolated from the deep-water

247 ctions between O2 and 1,2-dihydroxy-3-oxo-5-(methylthio)pent-1-ene (acireductone) depending upon the

248 ir common substrates (1,2-dihydroxy-3-oxo-5-(methylthio)pent-1-ene and dioxygen) are derived from the

249 the same substrate, 1,2-dihydroxy-3-keto-5-(methylthio)pentene, depending exclusively on the nature

250 ls from three model compounds, tert-butyl 2-(methylthio)peroxybenzoate, 3-methylthiopropionic acid, a

251 toward various cancer cells, out of which 4-(methylthio)phenyl)(naphthalen-1-yl)methanone O-2-(diethy

252 N-(2-Bromo-5-(methylthio)phenyl)-N'- (3-ethylphenyl)-N'-methylguanidin

253 [S-methyl-(11)C](+/-)-7-methoxy-3-(4-(4-(methylthio)phenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]a

254 ate, trans-1,2,3,5,6,10-beta-hexahydro-6-[4-(methylthio)phenyl[pyrrolo-[2,1-a]i soquinoline ((+)-(11)

255 betic characterization of 1,2-dihydro-4-[[4-(methylthio)phenyl]methyl]-5-(trifluoromethyl)-3H- pyrazo

256 trans-1,2,3,5,6,10-beta-Hexahydro-6-[4-(methylthio)phenyl]pyrrolo-[2,1-a]- isoquinoline ([11C]Mc

257 eled trans-1,2,3,5,6,10-beta-hexahydro-6-[4-(methylthio)phenyl]pyrrolo-[2,1-a]-isoquin oline ([(11)C]

258 le and readily available building blocks [2-(methylthio)phenylacetylenes, CO, an alcohol, and O(2) (f

259 group, consisting of allyl methyl sulfide, 1-methylthio-propane, (Z)-1-methylthio-1-propene, and (E)-

260 didate genes have been proposed for ethyl 3-(methylthio)propanoate and benzaldehyde biosynthesis.

261 Apart from allyl isothiocyanate also 3-(methylthio)propyl isothiocyanate is precursor to many su

262 (4))(2)(MTPA)(4)Cu(3)Cl(6) (Cu_Cu; MTPA = 3-(methylthio)-propylammonium) forms from solution as singl

263 le synthesis followed by methylation gave 2-(methylthio)pyrrole-2-(13)C.

264 id (MSIA), methane sulfenic acid (MSEA), the methylthio radical (CH(3)S), and hydroperoxymethyl thiof

265 ntial action of MTA phosphorylase (MtnP), 5-(methylthio)ribose-1-phosphate isomerase (MtnA), and an a

266 Prometryn is a methylthio-s-triazine herbicide used to control the grow

267 he enzyme MiaB catalyzes the attachment of a methylthio (-SCH(3)) group at the C2 position of N(6)-(i

268 SAM) enzymes that catalyze the attachment of methylthio (-SCH3) groups to macromolecular substrates.

269 -emitting tracer, 62Cu-pyruvaldehyde bis (N4-methylthio- semicarbazone)(62Cu-PTSM) and PET.

270 be isolated but immediately underwent a 1,2-methylthio shift to form bicyclic lactams in 60-100% yie

271 idge cycloadducts underwent a subsequent 1,2-methylthio shift to form tricyclic lactams in high yield

272 With alpha-bromoacetophenone and alpha-(methylthio)styrene, the reaction could be performed on a

273 the prokaryotic t6A nucleoside lacking the 2-methylthio substituent.

274 in imide position and chlorine, methoxy, or methylthio substituents in 1,7 bay-positions, revealed t

275 es, one stereoselective, for introducing the methylthio substituents of (+)-plectosphaeroic acid B we

276 and stereoselective introduction of the two methylthio substituents.

277 olecular Diels-Alder reaction of a 2-amido-5-methylthio-substituted furan containing a trans-pent-3-e

278 Explorative reactivity studies with the methylthio-substituted thiophene and pyrrole derivatives

279 nhibition is gained in the Immucillins by 5'-methylthio substitution which exploits the unique substr

280 n were prepared via the reaction of dimethyl(methylthio)sulfonium tetrafluoroborate (DMSTF) with beta

281 amido-substituted thioacetals with dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF) produces

282 n were prepared via the reaction of dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF) with beta

283 mma-thianyl carbonyl compounds with dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF).

284 dition of HOBr, HOCl, CH(3)SCl, and dimethyl(methylthio)sulfonium tetrafluoroborate (DMTSF)/NaN(3) wi

285 Treatment of cycloadduct 17 with dimethyl(methylthio)sulfonium tetrafluoroborate gave 2,5,6,7-tetr

286 ically defined hemilabile contacts based on (methylthio)thiophene moieties.

287 an up to ~100-fold sensitivity boost of the (methylthio)thiophene-terminated molecular wire compared

288 disulfide in the presence of NBS gave the 4-methylthio-thiophenes as sole products.

289 selenyl-selenophenes, halo-thiophenes, and 4-methylthio-thiophenes, were selectively prepared in good

290 Bromo and methylthio were the optimal substituents for the R2 and