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1 ranasally administered nicotine (0, 0.5, 1.0 mg) across three separate fixed dose experimental sessio
2 1) ) compared to the intact PSF (4.0 +/- 2.0 mg CH(4) m(-2) hr(-1) ) due to prolonged higher WT and m
3 rate among individuals with a bilirubin <2.0 mg/dL (C-statistic, 0.90; 95% CI, 0.82-0.96) and when th
6 tion of the selective agonist imiquimod (5.0 mg/kg) induces a phenotype in offspring characterized by
7 ty lipoprotein [LDL] cholesterol level, 75.0 mg/dL; median triglycerides level, 240 mg/dL; median HDL
11 /acetate signal), linearity (range 0.05-5.00 mg per assay), sensitivity (limit of detection and quant
12 0 mg/m(2)/dose on days 1-5; cytarabine 2,000 mg/m(2)/dose on days 1-5; and granulocyte-colony stimula
13 male survivors treated with 0 < CED < 4,000 mg/m(2) (P = 3.1 x 10(-4)) and 24 male survivors treated
16 gnificantly higher CH(4) flux (0.88 +/- 0.03 mg m(-2) hr(-1) ) than spring thaw (0.48 +/- 0.04 mg m(-
23 gh-sensitivity C-reactive protein level, 2.1 mg/L), 12 633 (96.6%) completed the trial with ascertain
24 holesterol level in the two groups was 255.1 mg per deciliter, despite the receipt of maximum doses o
25 omly assigned (1:1) to either anastrozole (1 mg per day, oral) or matching placebo daily for 5 years.
26 5 mg every 4 h, or combined haloperidol at 1 mg and chlorpromazine at 12.5 mg every 4 h, until death
27 e more reliably identified with ICG dose >=1 mg, albumin dissolvent, post-injection lung ventilation,
34 infusion of GSP results in a high yield (~1 mg/g) of trans-Res and improved photostability of infuse
36 f 25 mM LiCl in sucrose solution (6.50-40.10 mg/kg) or had the same solution available ad libitum (39
37 in a peripheral vessel in the right arm (10 mg/kg, providing therapeutic-level antibody concentratio
38 nificant difference between Mirococept at 10 mg and control was detected; hence the study was stopped
41 mg/kg cyclosporine A and received either 10 mg/kg prednisolone (P), or LP intravenously on day 0, 3,
47 ow-to-moderate arousal threshold received 10 mg zolpidem or placebo according to a double-blind, rand
48 d study, we investigated whether a single 10 mg dose of the GABA(B) agonist baclofen impaired motor s
49 group, and 60 (75%) of 80 patients in the 10 mg three times weekly group; the most common (>=20% pati
54 on as compared with placebo (P = 0.03 for 10-mg brensocatib vs. placebo; P = 0.04 for 25-mg brensocat
55 s of special interest was higher with the 10-mg and 25-mg brensocatib doses, respectively, than with
56 CI, -5.5 to 2.5; P = .47) and between the 10-mg/d vericiguat and placebo groups was -0.5 (95% CI, -4.
57 o received bendamustine on days 1 and 2 (100 mg/m(2) intravenously) with 40 mg of weekly dexamethason
58 plus acetylsalicylic acid (aspirin; ASA) 100 mg reduced the risk of cardiovascular events as compared
61 06 [98%] in placebo group, 108 [100%] in 100 mg group, 109 [99%] in 200 mg group, and 111 [100%] in 4
62 102 [94%] in placebo group, 102 [94%] in 100 mg group, 98 [89%] in 200 mg group, and 95 [86%] in 400
63 schedule, to adults mostly at a dose of 100 mg twice daily, and to paediatric patients mostly at a d
67 venously over 2 h and oral capecitabine 1000 mg/m(2) twice daily on days 1-14 repeated every 3 weeks
68 0 mesh Ottawa sand, injection of a PAC (1000 mg/L) + polyDADMAC (5000 mg/L) suspension created a sorp
69 enous iron was administered as a single 1000 mg dose of ferric carboxymaltose in 100 mL normal saline
71 , P = .019), C-reactive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004
72 M was tested with tap water spiked with 0.11 mg L(-1) of nine different HAAs in a similar reduction e
73 apagliflozin was 22% greater (+0.66 +/- 0.11 mg/kg/min, P < 0.05) than in subjects receiving placebo,
74 H values (9.9) and low DOC concentration (11 mg/L(-)) would maximize triclosan phototransformation ra
75 albumin with infusion of terlipressin (2-12 mg/day; n = 60) or noradrenaline (0.5-3.0 mg/h; n = 60).
77 mal and model control group), metformin (120 mg/kg.bw), and PLPE (600 mg/kg.bw) by oral administratio
78 n at the median dose of 600 (range, 29-1200) mg/day (mean, 8.6 +/- 3.6 mg/kg/day) for a median durati
79 and who had an LDL cholesterol level of 130 mg per deciliter (3.4 mmol per liter) or more and a trig
80 ry 2 weeks (regimen one), or oxaliplatin 130 mg/m(2) administered intravenously over 2 h and oral cap
83 not show any difference (DR: 0.03(-0.15,0.14)mg/dL vs. control: 0.09(-0.03,0.22)mg/dL;p = 0.797).
86 ring early pregnancy was determined to be 15 mg . kg-1 . d-1 (95% CI: 10.4, 19.9 mg . kg-1 . d-1); du
87 randomized to receive isoniazid 5, 10 or 15 mg/kg daily for 7 days (inhA group), and controls with d
88 res mean difference in scores between the 15-mg/d vericiguat and placebo groups was -1.5 (95% CI, -5.
89 ] and 6% [150 mg] vs 10% [placebo]; 24% [150 mg] vs 28% [placebo]) and 1 trial of nicotine replacemen
90 26 weeks (n = 523; 17% [300 mg] and 6% [150 mg] vs 10% [placebo]; 24% [150 mg] vs 28% [placebo]) and
91 atients received ASP4345 (3, 15, 50, and 150 mg; n = 9 each dose) and 12 patients received placebo.
92 ects design under three drug conditions: 150 mg of the dopamine precursor L-dopa, 2 mg of the D2 rece
94 ipants were randomized to receive either 150 mg/d of resveratrol (n = 20) or placebo (n = 21) for 6 m
95 more proteinuria (>=150 to <500 versus <150 mg/g), higher systolic blood pressure (>=140 versus 120
97 (34%) were randomly assigned to receive 150 mg S44819 twice a day, 195 (33%) to receive 300 mg S4481
98 uent TSS (61-820 mg L(-1)) and COD (384-1505 mg L(-1)), demonstrating a robust system for treating wa
99 up also received intravenous daratumumab (16 mg/kg of bodyweight, once weekly during cycle one, once
100 ents received selatogrel 8 mg (n = 24) or 16 mg (n = 23) followed by ticagrelor (n = 43) or clopidogr
102 intravenously over 2 h, l-folinic acid (175 mg flat dose administered intravenously over 2 h) or d,l
105 od and Agriculture Organization (FAO) of 0.2 mg/kg, whereas, all cadmium concentrations were below th
106 naloxone-methiodide at a very low dose (0.2 mg/kg; at which naloxone was undetectable in brain tissu
108 e higher in fire-affected areas (7.8 +/- 2.2 mg CH(4) m(-2) hr(-1) ) compared to the intact PSF (4.0
109 n berries was considerably lower (76.1-205.2 mg.kg(-1)) than in leaves (1477.7-8709.0 mg.kg(-1)).
111 mg/kg loading dose in the first week, and 2 mg/kg thereafter) for 9 weeks, starting concomitantly wi
112 intravenous haloperidol dose escalation at 2 mg every 4 h, neuroleptic rotation with chlorpromazine a
113 : 150 mg of the dopamine precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placeb
114 demonstrated that adjunctive BUP/SAM 2 mg/2 mg was superior to placebo (average difference change fr
115 treal administration of avacincaptad pegol 2 mg and 4 mg led to a significant reduction of GA growth
116 t and demonstrated that adjunctive BUP/SAM 2 mg/2 mg was superior to placebo (average difference chan
118 A demethylation, and safety vs decitabine 20 mg/m2 IV in the first 2 cycles, with similar efficacy.
121 ccurred in 71 (91%) of 78 patients in the 20 mg three times weekly group, 69 (83%) of 83 patients in
122 kly group, 69 (83%) of 83 patients in the 20 mg twice weekly group, and 60 (75%) of 80 patients in th
123 ns limit liquid nicotine concentration to 20 mg/mL, approximately one-third the level of JUUL product
126 the 98.75% CI, 1.0), and that between the 20-mg and 5-mg groups was 0.1 stools (upper boundary of the
127 interval [CI], 3.3), and that between the 20-mg and 5-mg groups was 0.7 percentage points (upper boun
128 fidence interval [CI], -18 to 27) for the 20-mg dose, -25 percentage points (95% CI, -40 to -5) for t
129 tarted within 4 days, reaching up to 100-200 mg.L(-1) of dissolved sulfide produced after 19-24 days,
132 ovir alafenamide 25 mg and emtricitabine 200 mg, and once-daily oral dolutegravir 50 mg; once-daily o
133 proxil fumarate 300 mg and emtricitabine 200 mg, and once-daily oral dolutegravir 50 mg; or once-dail
134 mulated bictegravir 50 mg, emtricitabine 200 mg, and tenofovir alafenamide 25 mg, or coformulated dol
135 was not reached (maximum dose evaluated, 200 mg twice a day); 150 mg once daily was established as th
136 108 [100%] in 100 mg group, 109 [99%] in 200 mg group, and 111 [100%] in 400 mg group) were included
137 , 102 [94%] in 100 mg group, 98 [89%] in 200 mg group, and 95 [86%] in 400 mg group) were included in
138 e the clinical activity of pembrolizumab 200 mg every 3 weeks, without restriction on prior therapy.
139 mg once daily orally plus pembrolizumab 200 mg intravenously once every 3 weeks, in 3-week cycles.
140 g late pregnancy, it was determined to be 21 mg . kg-1 . d-1 by DAAO (95% CI: 17.4, 24.7 mg . kg-1 .
142 75.0 mg/dL; median triglycerides level, 240 mg/dL; median HDL-C level, 36 mg/dL; and median high-sen
143 owed by a 46 h infusion of fluorouracil 2400 mg/m(2) repeated every 2 weeks (regimen one), or oxalipl
144 ke, a dose of 0.40 mg/kg, compared with 0.25 mg/kg, of tenecteplase did not significantly improve cer
145 receive 6 monthly injections of either 1.25 mg bevacizumab (n = 86) or 0.5 mg ranibizumab (n = 84).
146 plus luspatercept (at a dose of 1.00 to 1.25 mg per kilogram of body weight) or placebo for at least
147 ed-dose combination tenofovir alafenamide 25 mg and emtricitabine 200 mg, and once-daily oral doluteg
148 itabine 200 mg, and tenofovir alafenamide 25 mg, or coformulated dolutegravir 50 mg, abacavir 600 mg,
150 uroleptic rotation with chlorpromazine at 25 mg every 4 h, or combined haloperidol at 1 mg and chlorp
151 (n=448) were randomized 1:1:1 to placebo, 25 mg of OM BID, or to pharmacokinetically guided dose titr
152 Patients were randomized 1:1 to receive 25 mg clazakizumab or placebo (4-weekly subcutaneous inject
153 al interest was higher with the 10-mg and 25-mg brensocatib doses, respectively, than with placebo.
158 tors, the CB(2) agonist JWH133 (0.3, 1 and 3 mg/kg, IP) also produced anxiolytic-like effects in TMT-
160 Of the patients receiving NGM282 1 mg or 3 mg, 25% and 42%, respectively, improved liver fibrosis b
161 subject received 5 days of AVL-3288 (10, 30 mg) and placebo across three separate treatment weeks.
162 le 1: CPX-351; cycle 2: FLAG [fludarabine 30 mg/m(2)/dose on days 1-5; cytarabine 2,000 mg/m(2)/dose
163 rated noninferiority of once-daily 60 mg (30 mg dose-reduced) edoxaban compared with warfarin for pre
164 g development [subcutaneous injections of 30 mg/kg ketamine (KET) on postnatal days 7, 9, and 11] res
167 of bupropion at 26 weeks (n = 523; 17% [300 mg] and 6% [150 mg] vs 10% [placebo]; 24% [150 mg] vs 28
170 ombination tenofovir disoproxil fumarate 300 mg and emtricitabine 200 mg, and once-daily oral doluteg
175 low-nitrate vegetables + nitrate pills (300 mg nitrate), or leafy green vegetables containing 300 mg
176 S44819 twice a day, 195 (33%) to receive 300 mg S44819 twice a day, and 193 (33%) to receive placebo
178 ous dupilumab (600 mg loading dose, then 300 mg once weekly for 15 weeks [n = 30], or matched placebo
179 doses of apomorphine sublingual film (10-35 mg) were administered until a tolerable full on response
181 avenously over 2 h) or d,l-folinic acid (350 mg flat dose administered intravenously over 2 h), and f
184 des level, 240 mg/dL; median HDL-C level, 36 mg/dL; and median high-sensitivity C-reactive protein le
187 infected mice for FG2 HSA nanoparticles (0.4 mg/kg), FG 2 DMSO/saline (0.4 and 8 mg/kg) and a referen
191 alculations show air-cleaning prevented ~3.4 mg/h of indoor SOA formation due to indoor ozone-monoter
194 inistration of avacincaptad pegol 2 mg and 4 mg led to a significant reduction of GA growth in eyes w
196 mg/kg thereafter) for 18 doses or weekly (4 mg/kg loading dose in the first week, and 2 mg/kg therea
197 el occlusion ischemic stroke, a dose of 0.40 mg/kg, compared with 0.25 mg/kg, of tenecteplase did not
199 -, co- and post-incubating linezolid (0.4-40 mg/L) with healthy neutrophils relative to those with C5
200 (33.1%) had diuretic doses between 1 and 40 mg/day, and 1085 (16.4%) had diuretic doses >40 mg/day.
203 1 and 2 (100 mg/m(2) intravenously) with 40 mg of weekly dexamethasone in 28-day cycles until diseas
204 entage points (95% CI, -40 to -5) for the 40-mg dose, -19 percentage points (95% CI, -35 to 2) for th
205 nously over 2 h), and fluorouracil bolus 400 mg/m(2) administered intravenously over 5 min, followed
206 15 of cycle 1) with either capivasertib 400 mg or matching placebo, orally twice daily on an intermi
207 [99%] in 200 mg group, and 111 [100%] in 400 mg group) were included in the modified intention-to-tre
208 8 [89%] in 200 mg group, and 95 [86%] in 400 mg group) were included in the modified intention-to-tre
209 ter) or more and a triglyceride level of 400 mg per deciliter (4.5 mmol per liter) or less were rando
210 omparing monthly subcutaneous evolocumab 420 mg with placebo in PLHIV with hypercholesterolemia/mixed
214 d total analyzed phenolics ranging from 4387 mg/L (Eutric Cambisol) up to 8461 mg/L (Terra Rossa).
217 = 0.997, Cu = 0.506, Zn = 4.15 and I = 0.458 mg L(-1)) and mothers of full-term (Fe = 0.733, Cu = 0.2
228 to receive ruxolitinib orally, starting at 5 mg twice daily plus corticosteroids, until treatment fai
230 l comparing amiloride/hydrochlorothiazide (5 mg/50 mg daily) with dietary sodium restriction (60 mmol
236 % CI, 1.0), and that between the 20-mg and 5-mg groups was 0.1 stools (upper boundary of the 98.75% C
237 [CI], 3.3), and that between the 20-mg and 5-mg groups was 0.7 percentage points (upper boundary of t
238 ction to receive coformulated bictegravir 50 mg, emtricitabine 200 mg, and tenofovir alafenamide 25 m
239 nd tenofovir alafenamide, or dolutegravir 50 mg given with coformulated emtricitabine 200 mg and teno
240 amide 25 mg, or coformulated dolutegravir 50 mg, abacavir 600 mg, and lamivudine 300 mg once daily.
241 200 mg, and once-daily oral dolutegravir 50 mg; once-daily oral fixed-dose combination tenofovir dis
242 200 mg, and once-daily oral dolutegravir 50 mg; or once-daily oral fixed-dose combination of tenofov
243 aring amiloride/hydrochlorothiazide (5 mg/50 mg daily) with dietary sodium restriction (60 mmol per d
246 :1) to receive intramuscular fulvestrant 500 mg (day 1) every 28 days (plus a loading dose on day 15
247 tion of a PAC (1000 mg/L) + polyDADMAC (5000 mg/L) suspension created a sorptive region that increase
248 urine albumin-to-creatinine ratio 30 to 5000 mg/g and an estimated glomerular filtration rate >=25 to
249 everity of level 2 (blood glucose level, <54 mg per deciliter) or level 3 (severe cognitive impairmen
250 re than 0.5 and they took risperidone at 3-6 mg/day for at least a month before participating in the
252 0 (range, 29-1200) mg/day (mean, 8.6 +/- 3.6 mg/kg/day) for a median duration of 3 (range, 0.25-18) m
253 (8 mg/kg loading dose at first cycle, and 6 mg/kg thereafter) for 18 doses or weekly (4 mg/kg loadin
254 l Hg concentrations ranged from 0.49 to 1.60 mg/kg w.w. and showed a significant positive relationshi
255 demonstrated noninferiority of once-daily 60 mg (30 mg dose-reduced) edoxaban compared with warfarin
257 der, drug injection, and methadone doses <60 mg were independently associated with shorter time to HC
259 centage points (95% CI, -35 to 2) for the 60-mg dose, and -33 percentage points (95% CI, -47 to -16)
261 ized to commence subcutaneous dupilumab (600 mg loading dose, then 300 mg once weekly for 15 weeks [n
264 to add either fostemsavir (at a dose of 600 mg twice daily) or placebo to their failing regimen for
265 iven three times at 12 week intervals or 600 mg given five times, administered at one 4 week interval
269 cient), sham-surgery+strontium ranelate (625 mg/kg/d) (strontium/estrogen-sufficient); ovariectomy+st
270 s, the achieved LDL-C concentrations were 64 mg/dL (1.64 mmol/L) in the lower-target group and 106 mg
272 mg . kg-1 . d-1 by DAAO (95% CI: 17.4, 24.7 mg . kg-1 . d-1) and IAAO (95% CI: 10.5, 32.2 mg . kg-1
273 ained higher levels of alpha-tocopherol (6.7 mg/100 g), lipids (23.11 g/100 g, manly oleic and linole
275 lipoprotein cholesterol (LDL-C) levels >=70 mg/dl or non-high-density cholesterol >=100 mg/dl despit
276 MACCE reduction only if 1-year LDL-C was <70 mg/dl (hazard ratio: 0.61; 95% confidence interval: 0.40
277 active protein [138 mg/L (IQR: 83-179) vs 73 mg/L (IQR: 12-98), P < 0.01), lactate [1.1 mmol/L (IQR:
279 rong rising HMF contents (max.: Arabica: 769 mg/kg, Robusta: 364 mg/kg) followed by a distinct declin
280 ur), and a C-reactive protein level of 203.8 mg/L (1940.9 nmol/L) (normal range, <=10 mg/L [<=95.2 nm
281 ur), and a C-reactive protein level of 203.8 mg/L (1940.9 nmol/L) (normal range, <=10 mg/L [<=95.2 nm
282 les (0.4 mg/kg), FG 2 DMSO/saline (0.4 and 8 mg/kg) and a reference compound, BTZ043, DMSO/saline (0.
284 Forty-seven patients received selatogrel 8 mg (n = 24) or 16 mg (n = 23) followed by ticagrelor (n
285 asma obtained pre- and post-TCZ treatment (8 mg/kg, 6x, monthly) from 12 cAMR patients who failed sta
286 administered intravenously every 3 weeks (8 mg/kg loading dose at first cycle, and 6 mg/kg thereafte
287 us infusion of the same n-apo AI (CSL111, 80 mg/kg) similarly reduced the level of circulating leukoc
289 to long-acting injectable cabotegravir (800 mg given three times at 12 week intervals or 600 mg give
290 ide range of values for influent TSS (61-820 mg L(-1)) and COD (384-1505 mg L(-1)), demonstrating a r
292 Chemotherapy consisted of oxaliplatin 85 mg/m(2) administered intravenously over 2 h, l-folinic a
293 to be 15 mg . kg-1 . d-1 (95% CI: 10.4, 19.9 mg . kg-1 . d-1); during late pregnancy, it was determin
296 participants were randomized to receive 960 mg of oral co-trimoxazole twice daily (n = 170) or match
298 g reservoir potential of well over a year at mg/day dosing and may not require cold chain storage for
300 rticles (MNP) with a capacity of 373 pmolPNA/mg and coated with poly(N-acryloylglycine) (PNAG) showed