ライフサイエンスコーパス: miRNA

1 miRNA 3' ends are subject to frequent sequence modificat

2 miRNA alterations have a significant impact on the forma

3 miRNA-21-3p and miRNA-150-5p expression were significant

4 miRNAs are considered efficient candidate biomarkers due

5 miRNAs recognize target RNAs via sequence complementarit

6 miRNAs were detected in two of 72 plasma samples (2.8%)

7 We measured serum levels of 2,083 miRNAs, using RNA sequencing technology, in fasting samp

8 The levels of 13 miRNAs differed (p-value < 0.05; FC > 1.5) in CD patient

9 Notably, 14 miRNAs exhibited significant expression differences in P

10 iated with FEV(1)% change (P <= 0.05) and 15 miRNAs with significant interaction (P <= 0.05) to ICS v

11 rformed target gain and loss analysis of 163 miRNAs and our results showed that few miRNAs remained u

12 ent map of pairwise interactions between 171 miRNA-binding sites and identified synergistic and redun

13 rg false discovery rate [FDR] showed that 18 miRNAs were significantly altered (1 downregulated 4 up

14 Function analysis shows that the top 20 miRNAs regulate multiple cell fate related function modu

15 We identified 594 miRNAs, 2197 miRNA-target genes, and 3730 repeat-associated siRNAs (m

16 A total of 333 miRNAs were reliably detected in the total tissue fracti

17 Additionally, by identifying let-7i-3p miRNA as a strong inhibitor of Salmonella replication an

18 47 miRNAs were expressed in EVs and 16 thereof were signifi

19 stress states in these data, we identified 5 miRNA (including let-7f-5p and miR-181a-5p) and 4 tRNA t

20 We identified 594 miRNAs, 2197 miRNA-target genes, and 3730 repeat-associa

21 a modest effect on host miRNAs, with only 6 miRNAs differentially expressed during infection.

22 asurements and Main Results: We identified 7 miRNAs significantly associated with FEV(1)% change (P <

23 rse effects via negative regulation of let-7 miRNAs and other RNA targets-in cell and animal models c

24 We generate 977 miRNA-sequencing profiles from primary monocytes from in

25 rol expression of transgenes, we developed a miRNA regulation system that is activated only when HSPC

26 Therefore, we identify a miRNA:mRNA network that contributes to formation of fibr

27 turation, where it becomes the most abundant miRNA.

28 demonstration of an evolutionarily acquired miRNA in eutherians that refines cortical projection neu

29 ulator of a functionally related class of AF-miRNAs.

30 ications, which have been proposed to affect miRNA stability.

31 Changes in polysome-bound transcripts after miRNA inhibition were determined using translating ribos

32 Approximately half of all miRNA reside within intronic regions and are often cotra

33 miRNA-21-3p and miRNA-150-5p expression were significantly downregulated

34 The reduced expression of miRNA-21-3p and miRNA-150-5p was associated with peri-implantitis diagno

35 d significantly correlated TF-gene/miRNA and miRNA-gene/TF pairs with regulation direction.

36 gas, we systematically identified miRNAs and miRNA-targets in the mantles, which organ could produce

37 the first systematic investigation of TF and miRNA regulation and their co-regulation in two major TG

38 lin metabolism (miR-106b and miR-20b-5p) and miRNAs with functions in both skeletal muscle insulin me

39 determine the regulatory impact of genes and miRNAs expression over the GEBVs for the mineral amounts

40 Using our manually curated genes and miRNAs with evidence in CP in humans and mice, we constr

41 (EV) released by NK cells carry proteins and miRNAs able to exert an antitumoral effect, even within

42 ified MIR122, MIR200B-3p, and MIR200C-3p, as miRNAs that might bind to the occludin 3'UTR.

43 Using the identified non-linearly associated miRNAs much improves the cancer subtyping accuracy.

44 non-linearly and linearly outcome-associated miRNAs more accurately than the comparison methods.

45 talk between mitochondria and the associated miRNAs.

46 validated the function of the top associated miRNAs by luciferase reporter assays of glucocorticoid-m

47 nges of sample preconcentration for CE-based miRNA analyses and introduce a preconcentration method t

48 econcentration method that can suit CE-based miRNA analysis utilizing peptide nucleic acid (PNA) hybr

49 ly to a reduced rate of dissociation between miRNA-AGO complexes and their dual-site targets.

50 identified as potential targets regulated by miRNAs.

51 recise mutation of hth 3' UTR sites for BX-C miRNAs or deletion of its neural 3' UTR extension contai

52 ion that deletion of Bithorax complex (BX-C) miRNAs converts virgin female flies into a subjective po

53 s and reveal a previously unknown pan-cancer miRNA signature with patient prognostic power.

54 s an octopus that captures the target cancer miRNAs quickly and delivers them preferentially among DT

55 characterization, we quantified 11 candidate miRNAs associated with vascular performance and shuttled

56 on sequencing, we detected several candidate miRNAs from both EBOV and the closely related Marburg vi

57 es at the 5' and/or 3' ends of the canonical miRNA sequence.

58 Mirtrons are non-canonical miRNAs arising by splicing and debranching from short in

59 omic analysis indicates suboptimal canonical miRNAs are enriched in operons, and we validate several

60 be important for the activity of EV-carried miRNA in modulating gene expression in recipient cells.

61 ime-resolved datasets, we identified central miRNAs and specified common miRNA expression profiles.

62 s for TNRC6, which acts with AGOs to channel miRNA-mediated regulatory actions onto specific mRNAs, a

63 For this purpose, different on-chip miRNA bioassays based on sandwich and competitive format

64 Circulating miRNAs were associated with subsequent development of di

65 As circulating miRNAs are promising biomarkers for various diseases, we

66 concomitant with deregulation of circulating miRNAs, which were predicted regulators of transcripts d

67 Our aim was to determine whether circulating miRNAs from an early age in children with asthma would b

68 entified central miRNAs and specified common miRNA expression profiles.

69 Comprehensive miRNA profiling was performed on plasma-derived exosomes

70 We present a comprehensive miRNA profiling of naive-to-primed transition in hPSC, a

71 nce in CP in humans and mice, we constructed miRNA and transcription factor (TF) co-regulation networ

72 g genes frequently ignore any intron-derived miRNA.

73 Elafin, via immune-derived miRNAs and cytokine, activates leptin sensitivity and ex

74 Two parasite-derived miRNAs, cel-miR-71-5p and bma-lin-4, and O-150 repeat DN

75 The ability to detect miRNA-21 in human serum albumin and bovine serum albumin

76 opolymer, multiplex recognition of different miRNAs was demonstrated.

77 hat tropism could be redirected to different miRNAs.

78 ed when the two sites were for two different miRNAs or when the two sites were bound to miRNAs loaded

79 Differential miRNA expression among drought specific tissues indicted

80 and immune function, as well as differential miRNA expression (e.g., upregulated miR-34a, miR-7, and

81 ed dysregulation of members of the Dlk1-Dio3 miRNA cluster in muscle biopsies of the GRMD dog model.

82 e unable to effectively differentiate direct miRNA targets from downstream regulatory changes.

83 nds the RNA binding protein FMR1 and directs miRNA loading into exosomes via interaction with compone

84 tion pressure against mutations that disrupt miRNA binding.

85 ould be particularly suitable for dissecting miRNA regulatory networks in vivo.

86 DNA, miRNA, and metabolites were extracted from stool samples

87 elationship may exist between gut dysbiosis, miRNA profiling and SCFA level in response to intestinal

88 pinpointed several SE-specific dysregulated miRNAs (miR-200c-3p, miR-25-3p, and miR-302a-3p) and gen

89 I1, and TIMP3) and NSE-specific dysregulated miRNAs (miR-367-3p, miR-519d-3p, and miR-96-5p) and gene

90 Each miRNA can significantly predict MDS and MDS-T groups.

91 s found to be the inhibition of TPPP1 by EBV-miRNA-BART12, which, in turn, inhibits the acetylation o

92 is the first study to reveal the role of EBV-miRNA-BART12 in the development of EBV-related tumors as

93 y loop (miR17/miR20a-FOXE1-PDGFRA) and eight miRNAs (miR-140, miR-17, miR-18a, miR-19a, miR-19b, miR-

94 Most EBV-encoded miRNAs were found to be involved in the occurrence and d

95 he first virus found to carry genes encoding miRNAs.

96 on of a psychosis-altered and glial-enriched miRNA that controls neuronal gene expression is regulate

97 mber of differentially expressed PBMC and EV miRNAs appear significantly associated with severe ME/CF

98 nctioning at the synapse in MDD by examining miRNA processing machinery at synapse and sequencing miR

99 y reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice

100 sions are characterized by specific exosomal-miRNA signatures.

101 Differentially expressed miRNAs and mRNAs were validated using RT-qPCR.

102 ted gene targets of differentially expressed miRNAs are involved in neuroplasticity, immune function

103 re perturbed by the differentially expressed miRNAs.

104 family, which are the most highly expressed miRNAs in naive mouse PSC.

105 ate genome-wide measures of mRNA expression, miRNA expression, DNA methylation, and histone acetylati

106 ritical roles in regulating gene expression, miRNAs are strongly implicated in the pathophysiology of

107 f 163 miRNAs and our results showed that few miRNAs remained unchanged and many miRNAs from wild mice

108 del-scored Dynamic Programming algorithm for miRNA target site Selection) that can screen putative ta

109 nd (2'-O-methylation, 2'Ome) is critical for miRNA function in plants and Drosophila.

110 TXN1 levels, present additional evidence for miRNA-mediated gene regulation via 5' UTR binding, and r

111 The current criteria used for miRNA target prediction were inferred on a limited numbe

112 ns are similar to what we have described for miRNAs, including acting on apoptosis, M. leprae recogni

113 Furthermore, a total of four miRNAs and their target mRNAs were predicted to involve

114 characteristic curve analysis of these four miRNAs supported the discriminative potential for NTM-PD

115 determined significantly correlated TF-gene/miRNA and miRNA-gene/TF pairs with regulation direction.

116 steadily characterized a whole mouse genome miRNA related SNPs, analyzed their effects on the miRNA

117 ed unique transcriptomic profiles and global miRNA downregulation.

118 from cultured islets was purified and global miRNA profiling was performed with 3D-Gene global miRNA

119 profiling was performed with 3D-Gene global miRNA microarray mouse chips encompassing all mouse miRN

120 ctions onto specific mRNAs, are also heavily miRNA-targeted.

121 study TBI-induced changes in rat hippocampal miRNAs up to one year post-injury.

122 V infection had only a modest effect on host miRNAs, with only 6 miRNAs differentially expressed duri

123 Recent work has established how miRNAs are transported in body fluids often within exoso

124 Human miRNA profiles identified TBI across all acute and chron

125 ssostrea gigas, we systematically identified miRNAs and miRNA-targets in the mantles, which organ cou

126 d validate eight out of 15 of the identified miRNAs to demonstrate their role in deficit moisture str

127 Therefore, we identify miRNA whose 5p/3p strands function together to regulate

128 ubtypes with each disease cohort to identify miRNAs that are differentially enriched in aggressive ph

129 We developed a screen to identify miRNAs that regulate liver repopulation after injury in

130 m of action, analysis of EV cargo implicated miRNA (miR-124) as a potential candidate in the mitigati

131 cular and cellular consequences of imprinted miRNA activity.

132 We also detect marked differences in miRNA expression between populations, which are mostly d

133 nction of miRNA and a further improvement in miRNA-based diagnostic and prognostic applications.

134 tial alternatives to conventional methods in miRNA quantification.

135 e role of in vivo RNA secondary structure in miRNA cleavage by developing the new CAP-STRUCTURE-seq m

136 These included miRNAs with functions in skeletal muscle insulin metabol

137 e expression diversity of neurons, including miRNA profile data, we expect that the miRNA-based gene

138 tory principles of miRNAs in NSDs, including miRNA synergistic regulation in NSDs, miRNA modules and

139 tudies of intronic miRNA focus on individual miRNA, while conversely most studies of protein-coding a

140 Re-expression of individual miRNAs in B-cell lymphoma cells down-regulated expressio

141 miR-106b, which was identified as an induced miRNA in PCa.

142 insights into the range of stimulus induced miRNA abundance changes and lay the ground to identify e

143 eil the intricate interplay between intronic miRNA and their host transcripts in the modulation of ke

144 However, most studies of intronic miRNA focus on individual miRNA, while conversely most s

145 In this Perspective we present key islet miRNA families involved in T2D pathogenesis including mi

146 miR-451 is the only known miRNA whose processing bypasses Dicer and instead relies

147 pecifying the half-lives of most short-lived miRNAs.

148 ARP9 displayed reduced levels of AGO1-loaded miRNAs, partial retention of miRNA in the nucleus, and r

149 that few miRNAs remained unchanged and many miRNAs from wild mice gained target site.

150 Dicer and other components generates mature miRNA.

151 tool (miEAA) for human precursor and mature miRNAs.

152 ential changes in the distribution of mature miRNAs from the same precursor.

153 medical analyses was demonstrated, measuring miRNA-492 in undiluted serum samples.

154 ealing alternative trajectories for metazoan miRNA evolution.

155 rmine if there were differences in microRNA (miRNA) expression.

156 ress has been made in the field of microRNA (miRNA) research.

157 f the study was to identify plasma microRNA (miRNA) biomarkers for stratifying and monitoring patient

158 g of small interfering RNA (siRNA)/microRNA (miRNA) is a central component in this regulatory pathway

159 In cells, closely spaced microRNA (miRNA) target sites within a messenger RNA (mRNA) can ac

160 MicroRNAs (miRNAs) are critical post-transcriptional regulators of

161 MicroRNAs (miRNAs) are key regulators of the immune system, yet the

162 MicroRNAs (miRNAs) are sequentially processed by two RNase III enzy

163 MicroRNAs (miRNAs) are small non-coding RNAs that have been success

164 MicroRNAs (miRNAs) play a key role in mediating the action of insul

165 narily conserved lethal-7 (let-7) microRNAs (miRNAs) are well-known activators of proliferative quies

166 investigated whether circulating microRNAs (miRNAs) are associated with residual insulin secretion a

167 t studies showed that circulating microRNAs (miRNAs) may serve as noninvasive markers of TBI, we perf

168 ardiac biomarkers and circulating microRNAs (miRNAs), potentially indicating an increased hemodynamic

169 e epigenetic markers, circulating microRNAs (miRNAs), were associated with incident diabetes in Japan

170 ere, we discover 17 CSMN-enriched microRNAs (miRNAs), 15 of which map to a single genomic cluster tha

171 ) exosomes are highly enriched in microRNAs (miRNAs), which play an important role in neonatal immuni

172 scriptional regulators, including microRNAs (miRNAs), coordinate the T cell activation process.

173 Many microRNAs (miRNAs) have been associated with asthma and chronic obs

174 y characterize a large cluster of microRNAs (miRNAs) expressed from the maternally inherited allele (

175 Several approaches can be used for modeling miRNA regulation.

176 n of XPO5 compromises the biogenesis of most miRNAs and leads to severe defects during mouse embryoni

177 icroarray mouse chips encompassing all mouse miRNAs available on the Sanger miRBase V16.

178 Integrative analyses of mRNAs, miRNAs, lncRNAs, chromatin accessibility and cis-regulat

179 c modeling of the network effect of multiple miRNAs.

180 luding miRNA synergistic regulation in NSDs, miRNA modules and NSD modules.

181 G ligase accelerates degradation of numerous miRNAs in cells of mammals, flies, and nematodes, thereb

182 ding of TNRC6 enables cooperative binding of miRNA-AGO complexes to target RNAs, thereby explaining t

183 ggest that pestiviruses, although capable of miRNA-independent replication, took advantage of miRNAs

184 e are many studies on the characteristics of miRNA-mRNA interactions using miRNA and mRNA sequencing

185 The combination of miRNA enrichment assay, in silico analysis and molecular

186 Dysregulation of miRNA expression has been implicated in cancer.

187 The evaluation of miRNA polymerase chain reaction (PCR) arrays indicated t

188 to postulate a novel model for evolution of miRNA precursors in sea anemones and their relatives, re

189 The reduced expression of miRNA-21-3p and miRNA-150-5p was associated with peri-im

190 idant response, as well as the expression of miRNA-485, as a PGC1alpha upstream regulator.

191 g new insights into the cellular function of miRNA and a further improvement in miRNA-based diagnosti

192 itations and facilitate the investigation of miRNA functions in vivo, we have developed a method base

193 Here, we dissected the mechanism of miRNA dependency of the pestivirus bovine viral diarrhea

194 standard format, mirGFF3, for the output of miRNA/isomiR detection and quantification results from s

195 of AGO1-loaded miRNAs, partial retention of miRNA in the nucleus, and reduced levels of AGO1.

196 on) that can screen putative target sites of miRNA-target binding.

197 We propose that secondary structure of miRNA precursors induced by their MTA-dependent m(6)A me

198 soforms (isomiRs) are distinct variations of miRNA sequences, harboring addition or deletion of one o

199 A-independent replication, took advantage of miRNAs as essential host factors, suggesting a favorable

200 It also describes therapeutic delivery of miRNAs in different environments such as hypoxic tumor m

201 rate detection of differential expression of miRNAs can bring new insights into the cellular function

202 evidence for the developmental importance of miRNAs in a non-bilaterian animal.

203 t allow for the point-of-care measurement of miRNAs.

204 Methylation of miRNAs at the 2'-hydroxyl group on the ribose at 3'-end

205 A relatively dilute population of miRNAs can be found extracellularly in body fluids such

206 , we summarized the regulatory principles of miRNAs in NSDs, including miRNA synergistic regulation i

207 ques for the detection and quantification of miRNAs after these are extracted from diagnostic specime

208 Here, we examined the role of miRNAs and their functioning at the synapse in MDD by ex

209 h-throughput and ultrasensitive screening of miRNAs using labeling processes with focusing on the fut

210 rolled by largely non-overlapping subsets of miRNAs, seemingly reflecting different requirements prom

211 art, by differentially regulating subsets of miRNAs.

212 and offer an overview of studies focusing on miRNA discovery using profiling techniques and bioinform

213 gain new insights on the effects of SNPs on miRNA and their related sequences, we steadily character

214 cations and transformative potential as our 'miRNA classifier' can be used as a molecular tool to str

215 as noninvasive markers of TBI, we performed miRNA-seq to study TBI-induced changes in rat hippocampa

216 n a set of manually curated animal and plant miRNAs and demonstrated great accuracy.

217 ells was not due to reduced pri-miRNA or pre-miRNA levels.

218 Further processing of precursor miRNA by Dicer and other components generates mature miR

219 et interactions by disrupting each predicted miRNA-binding site by CRISPR-Cas9 genome editing in C. e

220 explain how Microprocessor recognizes a pri-miRNA and accurately identifies the cleavage site.

221 in infected cells was not due to reduced pri-miRNA or pre-miRNA levels.

222 e recruitment of Microprocessor to plant pri-miRNAs.

223 gs build on existing knowledge about primary miRNA maturation by the Microprocessor and further explo

224 on alternative splicing, 3' end processing, miRNA-mediated mRNA repression, of AR and AR-V expressio

225 ent of the ability of filoviruses to produce miRNA products during infection of both human and bat ce

226 al analysis demonstrates that the top-ranked miRNAs are significantly related to the overall survival

227 Rat miRNA profiles identified TBI across all acute and chron

228 ls, establish miR-124 as a cocaine-regulated miRNA in the mouse NAc, and highlight a novel pathway un

229 sensing are modulated by metformin-regulated miRNAs and that some of the regulated isomiRs (e.g. the

230 roaches revealed four novel CREB1-regulating miRNAs, namely miR-22-3p, miR-26a-5p, miR-27a-3p, and mi

231 imental methods to determine disease related miRNAs are time consuming and costly.

232 Newly identified MDR-related miRNAs (MDRmiRs) enhanced the response to anti-cancer th

233 public transcriptome datasets lack reliable miRNA profiles.

234 is known about the role of exosome-secreted miRNAs in the regulation of glutamate receptor gene expr

235 ocessing machinery at synapse and sequencing miRNAs and analyzing their functions in synaptic and tot

236 e analysis revealed misregulation of several miRNAs and other categories of sRNAs in silenced and ove

237 TDMD and expand its inferred role in shaping miRNA levels in bilaterian animals.

238 Furthermore, another CD31(+) EV-shuttled miRNA signature, i.e., miR-155, -320a, -342-3p, -376, an

239 Extracellular vesicle (EV)-shuttled miRNAs have been proposed as an alternative approach.

240 nstrated that therapeutic blockade of single miRNAs is possible.

241 ster and hence functionally inhibits all six miRNAs emanating from it.

242 e feature is the prediction of cell-specific miRNA targets.

243 ssion strategy to target cells with specific miRNA expression using miRNA-guided neuron tags (mAGNET)

244 e change in the expression level of specific miRNAs is an early event and plays a functional role in

245 ed maturation of a set of cell-type-specific miRNAs.

246 proach retained only 31 explanatory striatal miRNA-mRNA pairs that are precisely associated with the

247 Here, we present miEAA 2.0, supporting miRNA input from ten frequently investigated organisms.

248 anscriptional silencing of tumor-suppressing miRNAs in lymphoma cells and reinforce PRMT5's relevance

249 earch define TAp63 and its downstream target miRNAs, miR-30c-2*, and miR-497 as major players that ca

250 r proof of concept, we tested PNAs targeting miRNA-155 and employed poly(lactic-co-glycolic acid) (PL

251 This study aimed to identify AQP5-targeting miRNAs and examine their effects on breast cancer cell m

252 During TDMD, miRNAs undergo tailing and trimming, suggesting that thi

253 We found that 10 of the tested miRNAs are affected by T2DM, while the signature compose

254 y, we determined 288 and 664 dysregulated TF-miRNA-gene FFLs in SE and NSE, respectively.

255 Rescue experiments demonstrated that miRNA binding and 3' mutagenesis contribute to replicati

256 This approach revealed that miRNA target sites were not structurally accessible for

257 at sequencing studies have demonstrated that miRNAs are just the tip of the iceberg for sRNAs.

258 liver of Tsc1-knockout mice, and found that miRNAs of the delta-like homolog 1 (Dlk1)-deiodinase iod

259 We suggest that miRNAs may be useful in predicting future C-peptide decl

260 ine levels of miR-3187-3p, miR-4302, and the miRNA combination of miR-3187-3p/miR-103a-3p predicted d

261 In the current paper, we assessed the miRNA expression profile at different age time points an

262 ntifying the genes that are regulated by the miRNA-183 cluster provides researchers with important in

263 ase pairing between the 'seed' region of the miRNA and its counterpart mRNA(1).

264 uence abrogated the regulatory effect of the miRNA on the CPSF6 3'UTR.

265 ate despite the expected derepression of the miRNA targets.

266 RNA-binding protein AGO1, a component of the miRNA-dependent RNA-induced silencing complex (RISC).

267 on coefficients and expression values of the miRNA-mRNA pairs between tumor and normal samples is sti

268 related SNPs, analyzed their effects on the miRNA structural stability and target alteration.

269 In 2016, we published the miRNA enrichment analysis and annotation tool (miEAA) fo

270 Overall, these data suggest that the miRNA cargo of plasma CD31(+) EVs is largely affected by

271 Here, we present evidence that the miRNA is expressed from an intron that is generated by R

272 uding miRNA profile data, we expect that the miRNA-based gene targeting strategy presented here can h

273 cal properties can be readily related to the miRNA gene regulatory networks.

274 processed through, and function within, the miRNA pathway.

275 Of the miRNAs that were found to be differentially expressed ac

276 ather than inducing pseudouridylation of the miRNAs, high-throughput sequencing crosslinking immunopr

277 Recently, first therapeutic miRNA-based inhibitory strategies have been tested in he

278 monstrating direct interaction between these miRNAs and TOP2alpha/170 mRNA.

279 bited by the recombinant virus lacking these miRNAs to the wild type (17syn+), we found that during a

280 Many of these miRNAs significantly correlate with clinical variables h

281 oinformatics approach identified 10 of these miRNAs to be specifically related to the mitochondrial p

282 itive, respectively, the expression of these miRNAs was found to be inversely correlated with CREB1 p

283 of AQP5 protein abundance when each of these miRNAs was transfected into human breast cancer MDA-MB-2

284 YC, which are all predicted targets of these miRNAs, and reduced lymphoma cell survival.

285 r, these results strongly suggest that these miRNAs play a role in and are potential targets for circ

286 During fibrogenic transition, these miRNAs are transcriptionally regulated by the transcript

287 ts mechanisms of action, we showed that this miRNA specifically inhibits Salmonella infection via mod

288 enrichment analyses showed that these three miRNAs regulate target genes, which were predominantly e

289 the putative function of circRNA is through miRNA sponging, we found that miR-671-5p more potently s

290 Thus, miRNA assessment at baseline identifies associations wit

291 Thus, miRNAs contribute to the metabolic effects observed upon

292 t miRNAs or when the two sites were bound to miRNAs loaded into two different AGO paralogs, AGO1 and

293 hich may provide insights into understanding miRNA signaling underlying cancer cell metabolism and de

294 t cells with specific miRNA expression using miRNA-guided neuron tags (mAGNET).

295 acteristics of miRNA-mRNA interactions using miRNA and mRNA sequencing data, the complexity of the ch

296 nt of the potential for EBOV to encode viral miRNAs and provides evidence contrary to the existing pa

297 ing on computational methods alone for virus miRNA discovery.IMPORTANCE Here, we report the discovery

298 or various diseases, we investigated whether miRNAs have potential as NTM-PD biomarkers.

299 he discovery phase, we performed genome-wide miRNA expression profiling of 124 fresh, paired colorect

300 only cytokine significantly correlated with miRNAs (rho > 0.95).