ライフサイエンスコーパス: micelle

1 t of two FtsH hexamers in a single detergent micelle.

2 were located in the hydrophobic core of the micelle.

3 were located in the hydrophobic core of the micelle.

4 r-soluble, leading to destabilization of the micelle.

5 l for local cerebro-spinal administration of micelles.

6 ernally increasing the concentration of PIP2 micelles.

7 urified receptors reconstituted in detergent micelles.

8 n-glycero-3-phospho-(1'-rac-glycerol) (LPPG) micelles.

9 "native states" mostly obtained in detergent micelles.

10 m coclusters with membrane mimetic detergent micelles.

11 el and BTA-OEG(4)-Man formed small spherical micelles.

12 ids were well soluble and formed small mixed micelles.

13 h the presence of a coiled coil structure in micelles.

14 lles are more restricted than phosphocholine micelles.

15 DOPC and PGPC separate into vesicles and micelles.

16 h in native membranes and in mixed detergent micelles.

17 etic resonance of spin probes doped into the micelles.

18 ng apoptosis when compared to the individual micelles.

19 in water and locate the Bronsted catalyst in micelles.

20 ressing the solubilization capability of the micelles.

21 sequestering calcium, leading to swelling of micelles.

22 agments prior to reassembling into spherical micelles.

23 broad range of mutual miscibilities in mixed micelles.

24 ydrophobicity and stability of the assembled micelles.

25 e stability and enzymatic degradation of the micelles.

26 are essential for accessing SM in bile salt micelles.

27 s between proteins and mixed lipid/detergent micelles.

28 precludes high monomer concentration within micelles.

29 lization of cylindrical instead of spherical micelles.

30 o-(1'-rac-glycerol) membranes compared to OG micelles.

31 obic core of PLA-PEG-PLA thermogel-copolymer micelles.

32 ta, which weakened the therapeutic effect of micelles.

33 se of a standard LLC composed of disk-shaped micelles.

34 stabilization of purified GPCR in detergent micelles.

35 ity on interfacial water dynamics in reverse micelles.

36 o be densely packed within ~150 nm polymeric micelles.

37 glues comprised of spherical or cylindrical micelles.

38 -assembled nanocarriers known as three-helix micelles (3HM).

39 In bile, these exist as micelles above their critical micellar concentration (CM

40 gate self-assembled into micelles, and these micelles activate the glucagon-like peptide-1 receptor w

41 Mixed micelles adsorb on gold nanorods, forming quasihelical p

42 col)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles affect drug solubilization, and a paclitaxel (P

43 ting within surface/core doubly cross-linked micelles afforded water-soluble nanoparticle receptors f

44 microscopy showed that the process of casein micelle aggregation induced by CpCP3 was similar to that

45 First, we introduced a novel micelle-aided method to efficiently load imperialine int

46 soluble gold particles are released from the micelle and readily dispersed.

47 r dynamics simulations of Kv 1.2-VSD in LPPG micelles and a 1-palmitoyl-2-oleoyl-glycero-3-phosphocho

48 ution does not abrogate the interaction with micelles and bicelles at the high concentrations at whic

49 mogeneity, especially with respect to casein micelles and fat globules.

50 Self-assembled peptide micelles and fibers demonstrate unique control over the

51 yields an electron transfer pathway in both micelles and fibers that highlights the utility of the p

52 me active site binds carbon monoxide in both micelles and fibers, demonstrating that the heme active

53 en LRRC8A structures determined in detergent micelles and lipid bilayers related to reorganization of

54 ctivation as well as inhibition by detergent micelles and lipoprotein particles.

55 nked with various cargos like nanoparticles, micelles and liposomes to deliver drugs and genes to the

56 r molecules in the loop region of the VSD in micelles and membranes.

57 (PEG-b-PCL) form nano-assemblies, including micelles and nanoparticles, that increase the water solu

58 dary formed between the injected charged SDS micelles and neutral gamma-cyclodextrin (gamma-CD) zones

59 Efforts toward aqueous solutions utilizing micelles and other nanoencapsulants have been limited by

60 " conformation in both n-octylglucoside (OG) micelles and phospholipid membranes in the absence of me

61 cooperativity are observed between detergent micelles and proteoliposomes, the physiological implicat

62 nsport protein in both detergent-solubilised micelles and reconstituted proteoliposomes.

63 tures were determined by NMR spectroscopy in micelles and solved by using restrained molecular dynami

64 to synergistically combine the advantages of micelles and supramolecular coordination cages for targe

65 alts alone or with phospholipids, i.e. mixed micelles and the aqueous environment.

66 are limited to spherical micelles, wormlike micelles and vesicles.

67 ould be extracted and purified in surfactant micelles and was monodisperse and stable in vitro, with

68 c acceptor molecules encapsulated in polymer micelles and we show that the color of the emitted fluor

69 relaxation data, NMR data using spin-labeled micelles, and MD simulations of micelle-associated hATMf

70 by pretreating only a portion of the casein micelles, and modifying their colloidal calcium phosphat

71 in-cholesterol conjugate self-assembled into micelles, and these micelles activate the glucagon-like

72 luble vitamin loading in re-assembled casein micelles, and to evaluate vitamin D stability of dry for

73 he hydrophobic core of amphiphilic copolymer micelles, and was used to coordinate with biocompatible

74 )-b-polystyrene (PEO-b-PS) diblock copolymer micelles are cross-linked via Friedel-Crafts reaction, w

75 Surfactant-stripped micelles are formed from a commercially available cyanin

76 ound (T1) and photosensitizer (PS), The F127 micelles are liquid at room temperature and while formin

77 n in shorter chain detergents, and maltoside micelles are more restricted than phosphocholine micelle

78 Micelles are supramolecular assemblies arranged with the

79 ssure process to complexate bixin and casein micelles as a novel strategy for color delivery.

80 nted inventions and recent advances of these micelles as effective carriers for ocular drug delivery

81 Micelles, as a class of drug delivery systems, are under

82 Formulating paclitaxel in PEG-b-PLA micelles, as Genexol-PM(R), permits dose escalation over

83 itu atomic force microscopy (AFM) shows that micelle assembly occurs in two steps, starting with "pre

84 educing agent (2-ethylimidazole) into a mono-micelle assembly process, we present a type of ordered m

85 We show that micelle-assisted reaction can facilitate native chemical

86 clude that the observed dynamic structure of micelle-associated hATMfatc may enable it to interact wi

87 spin-labeled micelles, and MD simulations of micelle-associated hATMfatc revealed that it binds the m

88 hiphilic block copolymers that form discrete micelles at low concentrations and enter a phase of stro

89 Fiber-like micelles based on biodegradable and biocompatible polyme

90 This micelle-based methodology facilitates the generation of

91 Using a micelle-based nanoparticle therapy that recognizes integ

92 ntion, multi-responsive boronate crosslinked micelles (BCM) for ovarian cancer therapy.

93 therapeutic barrier, we developed polymeric micelles bearing active formats of irinotecan and oxalip

94 trated and utilized to reversibly switch the micelles between different morphologies.

95 ll as correlated dodecylphosphocholine (DPC) micelle binding and membrane-induced peptide conformatio

96 Moreover, H(N) chemical shifts of micelle-bound BM2 lack the periodic trend expected for c

97 s are observed between bilayer-bound BM2 and micelle-bound BM2, indicating that the TM helix conforma

98 en bonding in lipid bilayers differ from the micelle-bound conformation.

99 tide segment promotes the formation of mixed micelles, bringing the reacting peptides into close prox

100 self-assembly into size-specific cylindrical micelle building blocks for the hierarchical constructio

101 sociated hATMfatc revealed that it binds the micelle by a dynamic assembly of three helices with many

102 investigated in lipid bilayers and detergent micelles by solution NMR relaxation techniques.

103 how that a resonance assignment in detergent micelles can be transferred to a spectrum recorded in na

104 mation of diverse superstructures: colloidal micelles, chains, or bilayers, depending on the Janus ba

105 xygen species (ROS) to trigger the spherical micelles changing into nanofibers for strong retention i

106 The CHE micelles (CHE-M) had a size of 21 nm with CHE loading of

107 ide (NFX) to self-assemble co-prodrug-loaded micelles (CLM).

108 ecognition for silicic acid, followed by the micelle coalescence.

109 nanoentity types and sizes (dimers, n-mers, micelles, colloids, etc.), each having their own unique

110 dynamic and solvation properties of our OmpW-micelle complex using analytical ultracentrifugation and

111 The intact alphaHL micelle complexes are found to contain oligomeric state-

112 Polymeric micelles composed of poly(ethylene glycol-block-caprolac

113 ulsions at concentrations above its critical micelle concentration (cmc) of 0.6 mm, but also forms ge

114 h, and temperature conditions, with critical micelle concentration (CMC) values in the low micromolar

115 Their adsorption isotherms and critical micelle concentration (CMC) were also determined.

116 cyl sulfonate (SDS) were lower than critical micelle concentration (CMC), lipid oxidation products of

117 onto the droplet interface and an increased micelle concentration in the aqueous solution.

118 f current and about 0.015 times the critical micelle concentration of an ionic surfactant.

119 oxidizability O(i), and the critical reverse micelle concentration of LOOH, CMC(L).

120 at a level (500 ppm) lower than its critical micelle concentration was able to protect the lipid syst

121 betaine side chain and an ultralow critical micelle concentration, enabling drug penetration through

122 ts of surface tension isotherms and critical micelle concentrations (CMCs).

123 were significantly below published critical micelle concentrations and constituted <0.1% of overall

124 g cancer cells for drug delivery, KLAK-MCP-1 micelles consisting of a CCR2-targeting peptide sequence

125 uced self-assembly (photo-PISA) of spherical micelles consisting of proapoptotic peptide-polymer amph

126 ssential oil nano-assemblies of T80, swollen micelles containing TCA were successfully produced.

127 n silico experiments and by the agreement in micelle core and corona sizes obtained from microscopy o

128 , with ~50x greater cargo preference for the micelle core as described by two drug partitioning coeff

129 The micelles could dissociate under the high GSH level in ca

130 that the encapsulation of OR and TCA within micelles crucially improved their antibacterial activity

131 to formulate individual and dual drug loaded micelles (DDM) using the solvent evaporation method.

132 hat none of the three helices penetrates the micelle deeply or makes significant tertiary contacts to

133 Micelle degradation and gold nanoparticle dispersion was

134 The polymer micelle design was successfully translated to the Cu/Bip

135 The dynamics of phosphocholine and maltoside micelles, detergents frequently used for membrane protei

136 The micelle-directed mechanism allows extension to other sys

137 In vivo, (SN38 + DACHPt)-loaded micelles displayed superior antitumor and antimetastatic

138 osphocholine (POPC) bilayer showed that LPPG micelles do not induce significant structural distortion

139 Micelle/dropletsize, and minimal inhibitory concentratio

140 lock copolymer, that by itself does not form micelles due to its limited hydrophilic/lipophilic contr

141 ini-spidroins which are able to form protein micelles due to the addition of both terminal domains ex

142 ons of the amphiphilic polymer chains in the micelle (e.g., blocks' radii of gyration, chain radii of

143 outputs the structure of the self-assembled micelles (e.g., core and corona diameters, aggregation n

144 he analysis gives complexes of two connected micelles, each containing 10 RL and one protein in the s

145 We also analyze intact detergent micelle-embedded alphaHL porelike complexes by native IM

146 Here, we develop a micelle-enabled self-assembly approach for a binder-free

147 Micelles encapsulate either a mixture of uncoordinated a

148 ic alteration or through drug treatment with micelle encapsulated thiostrepton, leads to a reduction

149 with CHE loading of 0.5 mg/mL while the EVR micelles (EVR-M) and the DDM had a size around 35 and 39

150 acceptors that insert into cyclodextrin, the micelles exhibit highly efficient Forster resonance ener

151 The dual drug-loaded micelles exhibited improved colloidal stability, prolong

152 All polymeric micelles exhibited stability in cerebrospinal fluid, hig

153 nt reminiscent of unstructured proteins, the micelles favor triplet formation.

154 mPEG(2.2k)-CL(3.1k) and mPEG(2k)-LA(2).(7k) micelles favored dissolution whereas mPEG(5.4k)-LA(28.5k

155 red dissolution whereas mPEG(5.4k)-LA(28.5k) micelles favored stability.

156 and can be readily incorporated into aqueous micelles for biological use.

157 a potentially broad applicability of polymer micelles for encoded chemistry.

158 decanol into cetyltrimethylammonium chloride micelles for the assembly of lyotropic liquid crystals g

159 r X(PGPC) <= 0.2 and coexisting vesicles and micelles for X(PGPC) > 0.2 in gel and liquid-ordered pha

160 The kinetics of lipolysis, micelle formation and carotenoid bioaccessibility were m

161 ntration of the fatty acids can determine if micelle formation occurs, which in turn dictates the por

162 riven self-assembly for precise control over micelle formation to prepare a new recyclable catalyst p

163 jugated siRNAs, including hydrophobicity and micelle formation, which affected distribution.

164 Here, we synthesized a redox-sensitive nano-micelle formed by hyaluronic acid (HA) conjugated with d

165 ions demonstrate that the budding of reverse micelles formed from interfacial Sr(II) ion-extractant c

166 vity through the templating effect of chiral micelles formed in the presence of dissymmetric cosurfac

167 ution and with n-dodecyl-beta-d-maltoside, a micelle-forming detergent, we are able to discern the di

168 biliary cholesterol secretion, due to their micelle-forming properties.

169 he relationship between the lipid digestion, micelle fraction composition and beta-carotene bioaccess

170 of monounstaturated free fatty acids in the micelle fraction.

171 stable, and may expand the role of PEG-b-PLA micelles from "solubilizer" into "nanocarrier" for PTX a

172 over the length of low dispersity fiber-like micelles from 40 nm to 2.8 mum.

173 for the preparation of uniform 1D fiber-like micelles from a range of crystallizable polymeric amphip

174 Formation of mixed micelles from lipid-modified reactants shows promise for

175 ditions which drive the self-reproduction of micelles from phase-separated components.

176 Oligomeric micelles from sodium undecylenate (oSUD) were chemisorbe

177 ty (o(LA)(8)-PTX) specifically for PEG-b-PLA micelles, gaining higher loading and slower release of o

178 t solvent into the core of a block copolymer micelle, greatly reducing molecular aggregation.

179 Moreover, the OR or TCA loaded-micelles had only a slight droplet size variation upon t

180 Successful encapsulation into these micelles has been demonstrated for 1) several poorly sol

181 The anti-proliferative effects of these micelles have been tested in vitro in three ovarian cell

182 Over the past decades, polymeric micelles have emerged as one of the most promising drug

183 , of linoleic acid in sodium dodecyl sulfate micelles, have been determined in terms of oxygen consum

184 mic stacking boundary formed between charged micelles (i.e., from long chain ionic surfactants) and n

185 10 into surfactant-stripped CyFaP (ss-CyFaP) micelles improves yield, storage stability, and results

186 rbon - hydrophobic tail), ultimately forming micelle in coffee.

187 colloidal particle size than primary casein micelle in control MPI.

188 ns and enter a phase of strongly interacting micelles in a gradual manner with increasing concentrati

189 PcBOx copolymer self-assemble into polymeric micelles in aqueous solution.

190 the stability of amphiphilic block copolymer micelles in biologic fluids to identify the properties a

191 application of CCR2-targeted nanotherapeutic micelles in cancer treatment.

192 ns of NDAT were higher than DAT/Cremophor EL micelles in heart, lung, liver, spleen, and kidney.

193 PEG-dendron hybrids and their self-assembled micelles in order to determine their structure-stability

194 These polymers self-assemble into 28+/-5 nm micelles in water.

195 s of inhibition of the lipid peroxidation in micelles, in view of bibliographic data, have been made.

196 In vivo, KLAK-MCP-1 micelles inhibited tumor growth (34 +/- 11%) in a subcut

197 ologic fluids and offers evidence of polymer micelle instability in biologic fluids that is not expla

198 lating a freeze-dried powder of zwitterionic micelle insulin into an enteric-coated capsule.

199 e to, in part, to a lack of understanding of micelle interactions with biologic fluids following inje

200 ensitive positron-emitting neutral copolymer micelles into polycationic polymers, which are then inte

201 rafts reaction, which is a new way to anchor micelles into porous polymers with well-defined structur

202 from small silver NPs distributed inside the micelles into snowman-like asymmetric NPs, which hold pr

203 results suggest that the Shaker-VSD in LPPG micelles is in a native-like fold and is likely to provi

204 he formation of a dilute phase of individual micelles is prevented in polyelectrolyte complexation-dr

205 However, at higher concentrations, detergent micelles, latex nanobeads or lipoprotein particles inhib

206 ed transition from spheres to large compound micelles (LCM) in dilute solution, underwent phase separ

207 conditions, including protein mutations and micelle lipid composition, that lead to increased protei

208 of hydrophobic aggregates, such as detergent micelles, lipoprotein particles and even polystyrene lat

209 The self-assembly of Tween 80 (T80) micelles loaded with plant-based oregano essential oil (

210 ften used to solubilize membrane proteins in micelles, may disrupt lipid interactions that occur in b

211 rganization result from the net directional, micelle-mediated transport of oil between emulsion dropl

212 nanocarriers such as polymeric nanoparticles/micelles, metallic/inorganic NPs, and lipid-based NPs (L

213 Furthermore, the micelle microviscosity can be modulated with mixtures, a

214 ty of VD is influenced by formation of mixed micelles (MM) during digestion.

215 X is more compatible than PTX with PEG-b-PLA micelles, more stable, and may expand the role of PEG-b-

216 ular drug delivery system using unimolecular micelle nanoparticles (unimNPs) to prevent RGC loss.

217 xorubicin, self-assembled into monodispersed micelles [NP(BTZ-DOX)] with small particle sizes (20-30

218 and a unique class of photonic nanoporphyrin micelles (NPM), the extremely hydrophobic SN-38 was succ

219 pothesize that o(LA)(8)-PTX-loaded PEG-b-PLA micelles (o(LA)(8)-PTX-PM) has a lower C(max) and higher

220 quantitatively map the intracellular fate of micelles of a recombinant polypeptide conjugated with do

221 Mixed micelles of STC and 1-palmitoyl, 2-oleyl phosphatidylcho

222 netically pre-programming self-assembly into micelles of varied size and shape.

223 sing effect of sodium dodecyl sulphate (SDS) micelles on pH-induced colour variations of phycocyanin

224 mbrane protein can be conducted in detergent micelles, opening the possibility for the determination

225 ions, which were not recapitulated in simple micelle or vesicle models, indicating an exquisite sensi

226 strated advantageous behavior of cylindrical micelles or bottlebrush polymers over traditional spheri

227 - and Qa-SNAREs are concentrated in the same micelles or in cis on the same membrane.

228 ld be tuned by using the DDND in the form of micelles or in the form of thermoreversible gels, based

229 ports of chemically fuelled self-replicating micelles, our vesicular system was too stable to surfact

230 With surfactant micelles, oxidation of BODIPY(665/676) was observed.

231 s into helicoidally organized surface-pinned micelles (patches).

232 y was formed at the cyclodextrin zone as the micelles penetrated this zone.

233 inuous phase were associated with surfactant micelles, perhaps inhibiting their interaction with wate

234 Here we report a zwitterionic micelle platform featuring a virus-mimetic zwitterionic

235 This micelle platform was used to fabricate a prototype oral

236 lized, similar to a surfactant molecule in a micelle, pointing the farnesyl moieties into the hydroph

237 icrystalline nanoparticles, as a function of micelle pore expander concentration or stirring rate.

238 As the ratio increases toward a 1:1 micelle/porphyrin ratio, providing the chromophore with

239 ion, and a paclitaxel (PTX) loaded-PEG-b-PLA micelle (PTX-PM) is approved for cancer treatment due to

240 Despite the limited clinical translation, micelles remain an active area of research focus and pre

241 ng contribution of the surrounding detergent micelle rendered invisible.

242 uring digestion and incorporation into mixed micelles, requiring digestive enzymes, gastric peristals

243 ls to high-density lipoprotein and bile salt micelles, respectively.

244 obe to investigate the properties of reverse micelles (RMs) formed by the ionic liquid-surfactant 1-b

245 entrapped in two types of catanionic reverse micelles (RMs) on the kinetic parameters of the S(N)2 re

246 igh-density lipoprotein ([S]-HDL), polymeric micelles ([S]-PM), and liposomes ([S]-LIP), that are loa

247 these sub-100nm, SN-38-encapsulated photonic micelles show great promise for multimodal cancer therap

248 The critical concentration of LOOH reverse micelles showed significantly different values (10.0-41.

249 tein in the serum, and a reduction in casein micelle size (P<.05).

250 ling with oil and mixed surfactants increase micelle size dispersity, leading to complex clathrate ty

251 th quantitative and qualitative evidence for micelle stability within human biologic fluids and offer

252 Micelle stability, measured via Forster resonance energy

253 components of biologic fluids that influence micelle stability.

254 that phosphate residues have in maintaining micelle structural stability and provides new insights i

255 Full characterization of the micelles structures and comparison to the fibers lead to

256 ir molecular monomers self-associate to form micelles, termed the critical micellar concentration (CM

257 d to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic clea

258 oligomer states are consistent with polymer micelles that are limited in size by the stretching entr

259 The mPEG-PDLLA form micelles that can be loaded with two-photon absorption c

260 heet-forming peptoids, we obtain cylindrical micelles that further assembly into membranes and intert

261 l structures of MdfA, show that in detergent micelles, the protein adopts a predominantly outward-fac

262 made therein are in dynamic exchange between micelles through the water, opportunities exist to use e

263 y sequestered by, and incorporated into, the micelles, thus leading to efficient labelling of the mem

264 Analyte focusing by micelle to cyclodextrin stacking (MCDS) in micellar elec

265 from body-centered cubic (bcc) close-packed micelles to a succession of Frank-Kasper phases (sigma t

266 the way, largely due to the use of detergent micelles to protect and stabilize complexes.

267 ly loading silver cations into the polymeric micelles together with purification via centrifugation.

268 akage assay and the onset of the membrane-to-micelle transition by isothermal titration calorimetry.

269 sion was imaged in cultured macrophages, and micelle-treated mice displayed progressive physiological

270 ansformable peptides that self-assemble into micelles under aqueous conditions but, on binding to HER

271 undergo a morphology transition to worm-like micelles upon enzyme-triggered cleavage of coronal pepti

272 loop 3 (ICL3) was crystallized in detergent micelles using vapor-phase diffusion.

273 templated polymerization within cross-linked micelles, using readily available amino acid derivatives

274 Under the conditions where the SDS micelles velocity is faster than the electroosmotic flow

275 substrates, which are normally components of micelles, vesicles, and cellular membranes.

276 Release from photoactivatable polymers, micelles, vesicles, and photoswitches, along with the re

277 ood accordance with the theory of lipid disc micelle vesiculation.

278 the binding affinity of each peptide to DPC micelles was determined, revealing that BL6 displayed a

279 uspension of native and pre-acidified casein micelles was observed using rheology.

280 When skim milk containing pre-acidified micelles was re-equilibrated to the original pH no gelat

281 er-compatible C60-monoadduct based imprinted micelles was synthesized by the self-assembly of vinylic

282 When pre-concentrated micelles were acidified, an earlier gelation point was s

283 The micelles were found to form across a broad range of pH,

284 The reported micelles were found to solubilize hydrophobic metal comp

285 In vitro, KLAK-MCP-1 micelles were observed to bind and induce cytotoxicity t

286 Pre-acidified micelles were prepared by addition of glucono-delta-lact

287 Crosslinked micelles were prepared using amphiphilic PEG-b-poly(L-gl

288 a-CD) zones, where the analytes bound inside micelles were released due to the formation of stable SD

289 ered secondary structure upon binding to DPC micelles, whereas BL6 largely lacks secondary structural

290 ithout the need to fully strip the detergent micelle, which can cause significant gas-phase unfolding

291 sor" particles that transform into worm-like micelles, which extend and coalesce to form the higher o

292 , conventional native MS relies on detergent micelles, which may disrupt natural interactions.

293 utyl methacrylate) (ODB), self-assemble into micelles, which template pDNA winding around the cationi

294 BMS-529-complexed gp150 trimers in detergent micelles, which were isolated from CHO cells, bound to b

295 alization of the hydrophobic catalyst inside micelles while the hydrophilic catalyst remains in the b

296 In conclusion, re-assembled casein micelles with high loading efficiency show promise for i

297 efficient and reproducible method of loading micelles with hydrophobic drugs.

298 conventional delivery systems (e.g., PEG-PLA micelles with no co-encapsulated CaWO(4), or an organic

299 Micelles with spherical or wormlike morphologies were fo

300 om block copolymers are limited to spherical micelles, wormlike micelles and vesicles.