ライフサイエンスコーパス: microRNA

1 mones and light converging on a regulator of microRNA.

2 Fs were found in dual feedback motifs with a microRNA.

3 P epithelium due to an altered expression of microRNAs.

4 all molecular probes containing peptides and microRNAs.

5 ontrolling processing of the let-7 family of microRNAs.

6 been suggested to be controlled, in part, by microRNAs.

7 nematodes, with a focus on the functions of microRNAs.

8 ng genes, long intergenic noncoding RNAs and microRNAs.

9 ves, but surprisingly lacked >2000 bona fide microRNAs.

10 include both oncogenic and tumor suppressor microRNAs.

11 he downregulation of pluripotency associated microRNAs.

12 thin the MIR17HG gene and encodes six mature microRNAs.

13 To date, microRNA-1 (miR-1) is the only microRNA known to be regu

14 UTMD-mediated delivery of microRNA-122 and anti-microRNA-21 modulated the immune m

15 ectors containing a CaMKIIalpha promoter and microRNA-128 (miR-128) binding sites, and labeled CaMKII

16 MicroRNA-1300 (miR-1300) was the most potent and robust

17 (2020) demonstrate that microRNA-144 targets Dicer in a negative feedback loop,

18 nd elevated plasma levels of lipocalin-2 and microRNA-150, was associated with a fatal outcome in adu

19 Here, we investigate the role of microRNA-155 (miR-155), a proinflammatory host innate im

20 ndent of maturation and expression levels of microRNA-155 and PU.1 (as upstream regulatory axis of Fc

21 fied as the first dual inhibitor of AChE and microRNA-15b biogenesis.

22 For example, the primary microRNA-17-92 (pri-miR-17-92) cluster contains six micr

23 spondin-1) levels than control BEC; and that microRNA-18a (miR-18a) normalized AVM-BEC function and p

24 MicroRNA 199 (miR-199) negatively impacts pancreatic bet

25 MicroRNA-200 (miR-200) family is highly expressed in ova

26 as due at least in part to reduced levels of microRNA-200b-3p (miR-200b-3p), which represses ASH1L ex

27 Here we report that microRNA-204 (miR-204) promotes endothelial dysfunction

28 equence to target the precursor to oncogenic microRNA-21 (pre-miR-21) for enzymatic destruction with

29 agments that bind the precursor to oncogenic microRNA-21 (pre-miR-21).

30 tructural differences in sense and antisense microRNA-21 by hybridizing them with complementary RNA a

31 D-mediated delivery of microRNA-122 and anti-microRNA-21 modulated the immune microenvironment of Hep

32 We examined whether elevated microRNA-210 (miR-210) in cholestatic liver promotes BA-

33 A male-specific 35% nephron deficit in microRNA-210 knockout mice was observed.

34 n of caspase-8-associated protein 2, a known microRNA-210 target and apoptosis signal transducer.

35 Finally, microRNA 218-5p, which is downregulated in patients with

36 metabolism under the control of TGF-beta and microRNA 218.

37 n-1/DCC pathway by a mechanism that involves microRNA-218.

38 s downregulated in AF atrial cardiomyocytes; microRNA-26a silencing reproduced AF-induced IP(3)R1 upr

39 MicroRNA-26a was predicted to target ITPR1 (confirmed by

40 MicroRNA-27a/b are small non-coding RNAs which are repor

41 MicroRNA-31 (miR-31) is overexpressed in esophageal squa

42 MicroRNA 33a and 33b (miR-33a/b) bind to the 3' untransl

43 We aimed to evaluate microRNA-34a gene (MIR34A) expression in colorectal canc

44 athways that regulate VEGFA defined that the microRNA-377 precursor, which represses Vegfa messenger

45 efflux protein), revealing microRNA-4539 and microRNA-4261 respectively.

46 in) and ABCB1 (an efflux protein), revealing microRNA-4539 and microRNA-4261 respectively.

47 arks, and translational repression by miRNA (microRNA)-673/menin.

48 MicroRNA-744-5p (miR-744-5p) was identified as being of

49 ated that circDYM functions as an endogenous microRNA-9 (miR-9) sponge to inhibit miR-9 activity, whi

50 creases NGF by reducing lung fibroblast (LF) microRNA-98 (miR-98) and PPARgamma levels, thus promotin

51 ith asthma.Conclusions: This study of sputum microRNA and mRNA expression from patients with asthma d

52 We measured microRNA and mRNA expression using quantitative RT-PCR.

53 We integrated and harmonized microRNA and mRNA transcriptome data from newly generate

54 ultaneously or for the combined detection of microRNA and mRNA.

55 Here, we confirm that miR-3085 is a microRNA and not another class of small RNA using (1) a

56 investigated potential associations between microRNA and platelet reactivity (PR), a marker of plate

57 MicroRNA and RNA profiling show that this variant disrup

58 e and implied a structural dichotomy between microRNA and tRF target sets.

59 placental secretome including glycoproteins, microRNAs and extracellular vesicles as potential biomar

60 oduction, impacting populations of canonical microRNAs and mirtrons.CONCLUSIONWe identified DGCR8 as

61 2 reveals widespread viral insertions, novel microRNAs and piRNA clusters, the sex-determining locus,

62 ed on the design and analysis of circulating microRNAs and their context-dependent regulation.

63 g upregulation of known cartilage associated microRNAs and those transcribed from the Hox complexes,

64 ding heat shock proteins, synapsin 1, unique microRNAs, and glutamate transporters.

65 ects on the nervous system, innate immunity, microRNAs, and many disease-relevant pathways.

66 loop structure with the potential to produce microRNAs, and the repeat RNA can aggregate when express

67 es in these organisms, we show that previous microRNA annotations contained not only many false posit

68 he fast, specific and simple quantitation of microRNAs are becoming crucial enablers of early diagnos

69 MicroRNAs are directly linked with cancer development, p

70 MicroRNAs are emerging as both diagnostic and therapeuti

71 MicroRNAs are important coordinators of circadian regula

72 NM), in order to identify which key mRNA and microRNAs are regulating this complex process in patholo

73 microRNAs are short, noncoding RNAs that can regulate hu

74 MicroRNAs are small endogenous regulatory RNAs which alt

75 Among them, microRNAs are special because individual gene sequences

76 MicroRNAs are widely studied as circulating biomarkers f

77 an feature, and evidence for tissue-specific microRNA arm switching as found in Bilateria is detected

78 ion in small RNAs-including species-specific microRNA arm switching-providing differential gene regul

79 The use of microRNAs as biomarkers has been proposed for many disea

80 Since the initial discovery of microRNAs as post-transcriptional, regulatory key player

81 hlight the differential expression of eleven microRNAs associated with a physiological response to PE

82 capable of assaying five different types of microRNAs at an attomolar detection limit.

83 novel resource will aid future research into microRNA-based regulatory mechanisms responsible for cel

84 least, in part, through inhibition of let-7 microRNA biogenesis.

85 ed in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNA

86 This study showed that intrathecal microRNA can be used as a potential treatment for SOD1-m

87 The ten microRNAs can then serve as potential biomarkers and pro

88 162 microRNAs changed in expression during transdifferentiat

89 s system (CNS), it is difficult to attribute microRNA changes to a particular cell type.

90 he sensing of upcoming biomarkers, including microRNA, circulating tumor cells, exosomes, and cell-fr

91 nce resulting from loss of regulation by the microRNA cluster miR-15b/16 lowered the threshold for li

92 The microRNA cluster miR-17-92 is located within the MIR17HG

93 nals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiat

94 Indeed, curated microRNA complements of closely related organisms are ve

95 Mice inoculated with a nontarget microRNA control ZIKV demonstrated increased expression

96 iptomics from propranolol exposure, and with microRNA data from IHs and propranolol exposure.

97 to 82% were microRNAs, with over 400 unique microRNAs detected per model.

98 -identified miRNAs are verified in the Human MicroRNA Disease Database (HMDD) and are related to brea

99 r analysis reveals that a total of 229 human microRNAs display altered expression as a consequence of

100 ry factors such as transcription factors and microRNAs establish and maintain gene expression pattern

101 how here that transient exposure to a single microRNA, expressed at early stages during normal develo

102 We show in mice that microglial microRNA expression differs in males and females and tha

103 ve feedback loop, affecting global canonical microRNA expression in erythrocytes.

104 Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients befo

105 MicroRNA expression obtained before and after ozone expo

106 MicroRNA expression profiling of the lung tissue was per

107 The identification of distinctive microRNA expression signatures for ME/CFS through a prov

108 highlight data indicating that differential microRNA expression, specifically miR-326, may in part e

109 to enable exploration of cell type enriched microRNA expression.

110 ranscriptional profiling for mRNA and miRNA (microRNA) expression were performed.

111 th DNA (seven G6PD mutations) and RNA (let-7 microRNA family members) targets while retaining the sam

112 nderstanding of the structural dependency of microRNAs for their biological functions is essential fo

113 A key finding is six microRNAs from CCEN that impact patient survival at all

114 ificant in this analysis plus CVD-associated microRNAs from the literature were then quantified by ta

115 ed this by extensively expanding our curated microRNA gene database - MirGeneDB - to 45 organisms, en

116 By consistently annotating and naming 10,899 microRNA genes in these organisms, we show that previous

117 Over 2000 microRNAs have been described in humans and many are imp

118 Although hundreds of microRNAs have been identified as differentially express

119 Individual microRNAs have been identified in airway samples.

120 n the 1990s, a total number of $2656$ mature microRNAs have been publicly described for Homo sapiens.

121 roRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease.

122 oded proteins, along with noncoding RNAs and microRNAs, hijack cellular proteins and pathways to cont

123 loss-of-function approaches targeting these microRNAs impaired angiogenesis, suggesting that these m

124 on predicted and validated targets of these microRNAs implicated derepressed TGF-beta signaling as a

125 aining the targets of endogenously expressed microRNA in D. melanogaster S2 cells.

126 le, hsa-miR-223-3p was the highest expressed microRNA in neutrophils and was associated with increase

127 complementary sequence to a myeloid-specific microRNA in the 3' untranslated region.

128 , and TFs regulate different combinations of microRNAs in a tissue-dependent manner.

129 useful for developing biosensors to quantify microRNAs in clinical samples and to design therapeutic

130 widespread changes in the expression of HSC microRNAs in fibrogenesis, but suggests a need for cauti

131 f miR-375, which is one of the most abundant microRNAs in MCCs.

132 To our knowledge, the potential roles of microRNAs in sepsis-induced pericyte dysfunction have no

133 ciples underpinning discovery of circulating microRNAs in terms of their sorting and targeting, with

134 ds to characterize cells expressing specific microRNAs in the mouse retina.

135 Multiple microRNAs in the nely module correlated with two mRNA mo

136 Of the 12 microRNAs in the nely module, hsa-miR-223-3p was the hig

137 The role of microRNAs in the pathogenesis of Chagas disease has not

138 HCR methods can be used for the detection of microRNAs in tissue sections from mouse retinas.

139 tial studies focusing on the role of miRNAs (microRNAs) in cardiovascular development and disease.

140 ybridization for miR-517a/c, a C19MC cistron microRNA, in first trimester human placentas displayed s

141 These sets of microRNAs include both oncogenic and tumor suppressor mi

142 ificant changes in the expression of several microRNAs including upregulation of known cartilage asso

143 ter SEFL and identified persistently changed microRNAs, including mir-135b-5p, and proteins associate

144 Changes in expression of some microRNAs, including miR-17, miR-150, and miR-155, sugge

145 tified Argonaute 1 (AGO1; a key component of microRNA-induced silencing complex) as a crucial regulat

146 iours, such as autoregulation or feedback by microRNAs, is unknown.

147 MicroRNA isoforms (isomiRs) are distinct variations of m

148 tifying expression from unannotated loci and microRNA isoforms (isomiRs).

149 To date, microRNA-1 (miR-1) is the only microRNA known to be regulated in the lung endothelium i

150 uncation leads to a loss of target sites for microRNAs known to repress translation of LDLR.

151 iffers in males and females and that loss of microRNAs leads to sex-specific changes in the microglia

152 igned that specifically detect precursors of microRNAs let7b and miR-206.

153 emic stroke, comprising massive decreases of microRNA levels and concomitant increases of transfer RN

154 bubble destruction (UTMD) to locally deliver microRNA-loaded nanoparticles to HCC.

155 with associated examination of ACE2-related microRNA.Measurements and Main Results: 1) ACE2 is expre

156 ulated by increases in GrB transcription and microRNA-mediated posttranscriptional regulation of PRF

157 tudy defines deterministic components in the microRNA-mediated reprogramming cascade.

158 DNA methylation, histone modifications, and microRNAs mediates hyperglycemia-induced JunD downregula

159 miR-17, miR-150, and miR-155, suggested that microRNAs might play a significant role in regulation of

160 ssociated sensory nerves through loss of the microRNA miR-34a.

161 occurs, at least in part, via activation of microRNA miR-7.

162 ere, we reveal insights into the activity of microRNAs miR-9/9(*) and miR-124 (miR-9/9(*)-124) as rep

163 microRNA (miR) profiling of breast tissue identified miR

164 Small noncoding RNAs (sncRNA), including microRNA (miR), are expressed by many viruses to provide

165 w here that the SMPD1 gene is regulated by a microRNA (miR), miR-15a, in endothelial cells (ECs).

166 wound-edge keratinocytes, the expressions of microRNA (miR)-17, miR-18a, miR-19a, miR-19b, and miR-20

167 MicroRNA (miR)-1946a is predicted to bind to the TGFbeta

168 xosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which w

169 These findings strongly suggest that microRNAs (miR-24-4, miR-21), cytoskeleton remodeling, r

170 Here we aimed to investigate the roles of microRNA(miR)-124, a novel ER stress suppressor, in As-i

171 embryos, we identified an autosomal-derived microRNA, miR-1-3p, that has predicted target sites in t

172 associated with a decrease in its regulatory microRNA, miR-148b-3p.

173 he detection of pancreatic cancer-associated microRNA, miR-196b.

174 Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to at

175 We observed the microRNA, MIR138, to be upregulated in singleton preecla

176 y, ABI3 directly represses a gene encoding a microRNA (MIR160B) that targets AUXIN RESPONSE FACTOR (A

177 Submergence induced changes in levels of the microRNAs miR2936 and miR398, but this had no obvious ef

178 cientific studies due to its major role as a microRNA (miRNA) activity modulator and its association

179 Our study aimed to interrogate microRNA (miRNA) and metabolites, two biomolecules avail

180 le surveys of gut bacterial community, stool microRNA (miRNA) and short chain fatty acid (SCFA) signa

181 for a wide variety of small RNAs, including microRNA (miRNA) and tRNA fragments as well as 2'OMe mod

182 The aim of the study was to identify plasma microRNA (miRNA) biomarkers for stratifying and monitori

183 luence neuronal and glial function via their microRNA (miRNA) cargo has positioned them as a novel an

184 Here we found that the microRNA (miRNA) cluster including miR181ab1 is a key mo

185 We observed that the microRNA (miRNA) cluster mirn23a, coding for miRs-23a, -

186 It was previously shown that a BKPyV microRNA (miRNA) expressed from the late strand regulate

187 However, microRNA (miRNA) expression profiling analysis revealed

188 and 14 different AML cell lines by assessing microRNA (miRNA) expression, target protein expression,

189 unctions are tightly correlated with altered microRNA (miRNA) expression.

190 ic to determine if there were differences in microRNA (miRNA) expression.

191 report that CBs can associate with the C19MC microRNA (miRNA) gene cluster, which suggests a role for

192 trafficking of small interfering RNA (siRNA)/microRNA (miRNA) is a central component in this regulato

193 ice with hepatocyte-specific deficiencies in microRNA (miRNA) processing, but it is not clear which m

194 f RNA molecules are potentially important in microRNA (miRNA) processing, the role of the protein bin

195 MicroRNA (miRNA) regulation is associated with several d

196 tors in diabetes are aware of the success of microRNA (miRNA) research and appreciate the importance

197 ndous progress has been made in the field of microRNA (miRNA) research.

198 In cells, closely spaced microRNA (miRNA) target sites within a messenger RNA (mR

199 preferential expression of a 3' or 5' mature microRNA (miRNA), is a highly dynamic and tissue-specifi

200 MicroRNA (miRNA)-mediated cleavage is involved in numero

201 Aged mice deficient in microRNA (miRNA/miR)-146a succumb to life-shortening chr

202 MicroRNAs (miRNA) are transcriptional regulators and ess

203 pulations (micro-vesicles and exosomes), and microRNAs (miRNA-21-3p, miRNA-150-5p, and miRNA-26a-5p)

204 MicroRNAs (miRNAs) act in concert with Argonaute (AGO) p

205 ere are two broad categories of plant sRNAs: microRNAs (miRNAs) and endogenous short interfering RNAs

206 found in humans, and they are distinct from microRNAs (miRNAs) and small interfering RNAs (siRNAs).

207 We investigated whether circulating microRNAs (miRNAs) are associated with residual insulin

208 MicroRNAs (miRNAs) are critical post-transcriptional reg

209 e pathogenesis of type 2 diabetes (T2D), and microRNAs (miRNAs) are fundamental regulatory factors in

210 MicroRNAs (miRNAs) are implicated in the epigenetic regu

211 vidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in a broad spectrum of N

212 MicroRNAs (miRNAs) are key regulators of the immune syst

213 MicroRNAs (miRNAs) are sequentially processed by two RNa

214 MicroRNAs (miRNAs) are short noncoding RNAs which each c

215 MicroRNAs (miRNAs) are small non-coding RNAs that have b

216 MicroRNAs (miRNAS) are small noncoding RNAs and are impo

217 MicroRNAs (miRNAs) are small noncoding RNAs that act as

218 Among various noncoding RNAs, microRNAs (miRNAs) are the most studied and well charact

219 Primary microRNAs (miRNAs) are the precursors of miRNAs that mod

220 he evolutionarily conserved lethal-7 (let-7) microRNAs (miRNAs) are well-known activators of prolifer

221 MicroRNAs (miRNAs) associated with Argonaute proteins (A

222 MicroRNAs (miRNAs) base-pair to messenger RNA targets an

223 Based on recent reports that microRNAs (miRNAs) can interact with both 3' and 5' UTRs

224 Upon stress, ultraconserved microRNAs (miRNAs) down-regulate MISTR1(NDUFA4) followed

225 functionally characterize a large cluster of microRNAs (miRNAs) expressed from the maternally inherit

226 Microprocessor initiates the processing of microRNAs (miRNAs) from the hairpin regions of primary t

227 Many microRNAs (miRNAs) have been associated with asthma and

228 shown that the expression level of different microRNAs (miRNAs) is altered in neurodegenerative disor

229 The biological impact of microRNAs (miRNAs) is determined by their targets, and r

230 cause recent studies showed that circulating microRNAs (miRNAs) may serve as noninvasive markers of T

231 Selective inhibition of microRNAs (miRNAs) offers a new avenue for cancer therap

232 MicroRNAs (miRNAs) play a key role in mediating the acti

233 MicroRNAs (MiRNAs) play important roles in posttranscrip

234 A-17-92 (pri-miR-17-92) cluster contains six microRNAs (miRNAs) that collectively act in several dise

235 ansitions, which were exploited to recognize microRNAs (miRNAs) that populated unfolded hairpins.

236 Here, the contribution of BLC microRNAs (miRNAs) to stress-enhanced memory was investi

237 tformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested.

238 Here, we discover 17 CSMN-enriched microRNAs (miRNAs), 15 of which map to a single genomic

239 Small RNAs (sRNAs), including microRNAs (miRNAs), are noncoding RNA (ncRNA) molecules

240 d post-transcriptional regulators, including microRNAs (miRNAs), coordinate the T cell activation pro

241 As ncRNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) or ci

242 MicroRNAs (miRNAs), one of the most abundant classes of

243 impact on cardiac biomarkers and circulating microRNAs (miRNAs), potentially indicating an increased

244 and mice, from which we identified critical microRNAs (miRNAs), target genes and regulatory motifs (

245 whether the epigenetic markers, circulating microRNAs (miRNAs), were associated with incident diabet

246 an milk (HM) exosomes are highly enriched in microRNAs (miRNAs), which play an important role in neon

247 host immune responses by modulating numerous microRNAs (miRNAs).

248 tors such as transcription factors (TFs) and microRNAs (miRNAs).

249 rpes simplex virus 1 (HSV-1) expresses viral microRNAs (miRNAs).

250 regulation of gene expression, including by microRNAs (miRNAs).

251 MicroRNAs (miRNAs, miRs) are small noncoding RNAs that m

252 microRNAs (miRs) are small non-coding molecules that reg

253 MicroRNAs (miRs) are small non-coding RNAs that can have

254 MicroRNAs (miRs) regulate gene expression in health and

255 he airway.Measurements and Main Results: Six microRNA modules were associated with clinical features

256 RNA candidates and the corresponding circRNA-microRNA-mRNA axes, particularly those involving ASD ris

257 We described a microRNA network which contributes to the observed down-

258 network analysis was implemented to identify microRNA networks (modules) that significantly correlate

259 ts with asthma demonstrates the existence of microRNA networks and genes that are associated with fea

260 Knocking down the microRNAs or deleting their seed sites on Drd1 mimicked

261 twork (CCEN) composed of an invariant set of microRNAs over all the stages and stage-dependent, uniqu

262 sumably produced by an altered expression of microRNAs, particularly of those miRs belonging to mir-3

263 ng show that this variant disrupts precursor microRNA production, impacting populations of canonical

264 others have explored the potential value of microRNA profiles (miRNomes) as diagnostic tools for thi

265 n, altered gene expression levels, distorted microRNA profiles, and a global loss of cytosine hydroxy

266 Combined inhibition of these three microRNAs reduced spontaneous seizures in epileptic mice

267 egrate ENCODE mRNA/miRNA data with predicted microRNA response elements to prioritize tissue-specific

268 ures, clinical features, and next-generation microRNA sequencing from micro-dissected formalin-fixed

269 MicroRNA sequencing identified a significant change in t

270 validated the prognostic value of candidate microRNA signatures and contextualized them in relevant

271 MicroRNA significant in this analysis plus CVD-associate

272 itu HCR can be used for the detection of two microRNAs simultaneously or for the combined detection o

273 first and unique small-molecule enhancer of microRNA (SMER) maturation.

274 in humans and other species and can overcome microRNA stability and isomiR challenges.

275 realized to predict the targets of a set of microRNAs, starting from their expression profile.

276 To facilitate interpretation of microRNA studies in these tissues, we used previously ge

277 transcription factor binding site (TFBS) and microRNA target data to generate a gene interaction netw

278 to test the phenotypic impact of individual microRNA-target interactions by disrupting each predicte

279 ) vector-based system encoding an artificial microRNA targeting CD33 (miRCD33) into APP/PS1 mice redu

280 of several factors such as the TATA-box and microRNA targeting on intrinsic or extrinsic noises and

281 nfusion of adeno-associated virus encoding a microRNA targeting SOD1.

282 regions is more efficient in predicting the microRNA targets, with respect to the algorithm trained

283 hat autoregulate have more interactions with microRNAs than non-autoregulatory genes and 89% of autor

284 eal a critical role for miR-466o-3p, a novel microRNA that has not been characterized previously, in

285 Let-7 is an evolutionary conserved microRNA that mediates post-transcriptional gene silenci

286 riginally identified as an anti-inflammatory microRNA that targets signaling proteins, which mediate

287 act patient survival at all stages, and four microRNAs that affect the survival from a specific stage

288 We investigated microRNAs that are regulated by IL1B and their effects o

289 Significant changes of cerebrospinal fluid microRNAs that control inflammation, neuronal injury, au

290 We prioritized commonly up-regulated microRNAs that were fully conserved in humans and design

291 n; producing noncoding viral RNAs (including microRNAs) to suppress lytic gene expression or regulate

292 on the network analysis of transcriptome and microRNAs, we found that the oversupply of glucose-induc

293 Dual feedback motifs with microRNAs were also conserved between tissues, but less

294 Approximately half of the detected microRNAs were dysregulated in each epilepsy model.

295 mentally validated bat-specific variation in microRNAs, which may regulate bat-specific gene-expressi

296 dependent RNA stem-loop based on pre-miR-451 microRNA-which is highly enriched in small extracellular

297 rmatics databases for unpublished/unexplored microRNAs with high nucleotide sequence correspondence t

298 n clinical samples and to design therapeutic microRNAs with robust functionality.

299 thermore, we compared profiling of human HSC microRNAs with that of rat HSC so as to identify those m

300 lion small RNA reads of which up to 82% were microRNAs, with over 400 unique microRNAs detected per m